H0186 Material Safety Data Sheet PROTECTIVE CLOTHING RISK PHRASES HAZARD WARNINGS Toxic compound, do not ingest or inhale. Avoid all contact with this material. Environmental hazard. This material is very toxic to aquatic organisms. Irritating to skin, eyes, and the respiratory system. CARCINOGEN. MINIMIZE EXPOSURE. POSSIBLE MUTAGEN. MINIMIZE EXPOSURE. Air and light sensitive material. Section I. Chemical Product and Company Identification Chemical Name Hydroquinone Catalog Number Supplier H0186 TCI America 9211 N. Harborgate St. Synonym Portland OR 1,4-Dihydroxybenzene 1-800-423-8616 Chemical Formula C 6H 6O 2 CAS Number Section II. In case of Emergency Call 123-31-9 Chemtrec® (800) 424-9300 (U.S.) (703) 527-3887 (International) Composition and Information on Ingredients Chemical Name CAS Number Hydroquinone Percent (%) Min. 99.0 (T) 123-31-9 Toxicology Data TLV/PEL This chemical is classified as a Rat LD carcinogen. There is no Mouse LD acceptable exposure limit for Rat LD a carcinogen. mg/kg This compound is classified as Rat LD 50 (oral) 302 mg/kg 50 (oral) 245 mg/kg 50 (intraperitoneal) 170 50 (intravenous) 115 mg/kg a possible mutagen. There is no acceptable exposure limit for a mutagen. Section III. Acute Health Effects Hazards Identification T o x ic if in g e s t e d o r in h a le d . A v o id p r o lo n g e d c o n t a c t w it h t h is m a t e r ia l. O v e r e x p o s u r e m a y r e s u lt in s e r io u s illn e s s o r death. Ir r it a t in g t o e y e s a n d s k in o n c o n t a c t . In h a la t io n c a u s e s ir r it a t io n o f t h e lu n g s a n d r e s p ir a t o r y s y s t e m . In f la m m a t io n o f t h e e y e is c h a r a c t e r iz e d b y r e d n e s s , w a t e r in g , a n d it c h in g . S k in in f la m m a t io n is c h a r a c t e r iz e d b y it c h in g , s c a lin g , reddening, or, occasionally, blistering. Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound. Chronic Health Effects CARCINOGENIC EFFECTS : Carcinogenic by RTECS criteria. MUTAGENIC EFFECTS : Not available. TERATOGENIC EFFECTS : Tumorigenic Effects. Rat TDLo Oral 12875 mg/kg/103 weeks intermittent TOXIC Effects: Tumorigenic - Carcinogenic by RTECS criteria Blood - Leukemia Rat TDLo Oral 25750 mg/kg/2 years continuous TOXIC Effects: Tumorigenic - Carcinogenic by RTECS criteria Blood - Leukemia Rat TDLo Oral 174720 mg/kg/26 weeks continuous TOXIC Effects: Tumorigenic - Carcinogenic by RTECS criteria Lung, Thorax, or Respiration - Tumors Liver - Tumors DEVELOPMENTAL TOXICITY : Reproductive Effects. Rat TDLo Oral 667 mg/kg, female 11 days of pregnancy TOXIC Effects: Effects on Fertility - Post implantation mortality Rat TDLo Subcutaneous 550 mg/kg, female 11 days prior to mating TOXIC Effects: Maternal Effects - Menstrual cycle changes or disorders TDLo Subcutaneous 5100 mg/kg, male 51 days prior to mating TOXIC Effects: Paternal Effects - Testes, epididymis, sper duct Paternal Effects - Prostate, seminal vessicale, Cowper's gland, accessory glands Effects on Fertility - Male fertility index Continued on Next Page Printed 2/6/2007. Emergency phone number (800) 424-9300 H0186 Section IV. Eye Contact Hydroquinone Page 2 First Aid Measures C h e c k f o r a n d r e m o v e a n y c o n t a c t le n s e s . In c a s e o f c o n t a c t , im m e d ia t e ly f lu s h e y e s w it h p le n t y o f w a t e r f o r a t le a s t 1 5 minutes. Get medical attention. Skin Contact In c a s e o f c o n t a c t , im m e d ia t e ly f lu s h s k in w it h p le n t y o f w a t e r f o r a t le a s t 1 5 m in u t e s w h ile r e m o v in g c o n t a m in a t e d c lo th in g a n d s h o e s . W a s h c lo th in g b e fo r e r e u s e . T h o r o u g h ly c le a n s h o e s b e fo r e r e u s e . G e t m e d ic a l a tte n tio n immediately. Inhalation If t h e v ic t im is n o t b r e a t h in g , p e r f o r m m o u t h - t o - m o u t h r e s u s c it a t io n . L o o s e n t ig h t c lo t h in g s u c h a s a c o lla r , t ie , b e lt o r w a is t b a n d . If b r e a t h in g is d if f ic u lt , o x y g e n c a n b e a d m in is t e r e d . S e e k m e d ic a l a t t e n t io n if r e s p ir a t io n p r o b le m s d o n o t improve. Ingestion IN D U C E V O M IT IN G b y s t ic k in g f in g e r in t h r o a t . L o w e r t h e h e a d s o t h a t t h e v o m it w ill n o t r e e n t e r t h e m o u t h a n d t h r o a t . L o o s e n t ig h t c lo t h in g s u c h a s a c o lla r , t ie , b e lt o r w a is t b a n d . r e s u s c it a t io n . If t h e v ic t im is n o t b r e a t h in g , p e r f o r m m o u t h - t o - m o u t h E x a m in e t h e lip s a n d m o u t h t o a s c e r t a in w h e t h e r t h e t is s u e s a r e d a m a g e d , a p o s s ib le in d ic a t io n t h a t t h e toxic material was ingested; the absence of such signs, however, is not conclusive. Section V. Flammability Flash Points Combustion Products Fire Hazards Explosion Hazards Fire and Explosion Data Auto-Ignition May be combustible at high temperature. 165°C (329°F) Flammable Limits . These products are toxic carbon oxides (CO, CO 2 499°C (930.2°F) Not available. ). Not available. Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in presence of static discharge: Not available. Fire Fighting Media and Instructions SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet. Consult with local fire authorities before attempting large scale fire-fighting operations. Section VI. Spill Cleanup Instructions Accidental Release Measures T o x ic m a t e r ia l. E n v r io n m e n t a lly h a z a r d o u s m a t e r ia l. Ir r it a t in g m a t e r ia l. C a r c in o g e n ic m a t e r ia l. P o s s ib le m u t a g e n ic material. Air and light sensitive material. S t o p le a k if w it h o u t r is k . D O N O T g e t w a t e r in s id e c o n t a in e r . D O N O T t o u c h s p ille d m a t e r ia l. U s e w a t e r s p r a y t o r e d u c e vap o rs. P r e v e n t e n t r y in t o s e w e r s , b a s e m e n t s o r c o n f in e d a r e a s ; d ik e if n e e d e d . E lim in a t e a ll s o u r c e s o f ig n it io n . Consult federal, state, and/or local authorities for assistance on disposal. Section VII. Handling and Storage Information Handling and Storage T O X IC . E N V IR O N M E N T A L H A Z A R D . IR R IT A N T . C A R C IN O G E N . P O S S IB L E M U T A G E N . A IR A N D L IG H T S E N S IT IV E . K e e p lo c k e d up. K e e p a w a y fro m h e a t. c o o l p la c e . M e c h a n ic a l e x h a u s t r e q u ir e d . W h e n n o t in u s e , t ig h t ly s e a l t h e c o n t a in e r a n d s t o r e in a d r y , A v o id e x c e s s iv e h e a t a n d lig h t . D O N O T in g e s t . D o n o t b r e a t h e d u s t . W e a r s u it a b le p r o t e c t iv e c lo t h in g . If ingested, seek medical advice immediately and show the container or the label. Treat symptomatically and supportively. Always store away from incompatible compounds such as oxidizing agents, alkalis (bases). Section VIII. Engineering Controls Exposure Controls/Personal Protection U s e p r o c e s s e n c lo s u r e s , lo c a l e x h a u s t v e n tila tio n , o r o th e r e n g in e e r in g c o n tr o ls to k e e p a ir b o r n e le v e ls b e lo w r e c o m m e n d e d e x p o s u r e lim it s . If u s e r o p e r a t io n s g e n e r a t e d u s t , f u m e o r m is t , u s e v e n t ila t io n t o k e e p e x p o s u r e t o airborne contaminants below the exposure limit. Personal Protection S p la s h g o g g le s . L a b c o a t. in h a la t io n o f t h e p r o d u c t . D u s t r e s p ir a t o r . B o o ts . G lo v e s . A M S H A / N IO S H a p p r o v e d r e s p ir a t o r m u s t b e u s e d t o a v o id S u g g e s t e d p r o t e c t iv e c lo t h in g m ig h t n o t b e s u f f ic ie n t ; c o n s u lt a s p e c ia lis t B E F O R E h a n d lin g this product. Exposure Limits This chemical is classified as a carcinogen. There is no acceptable exposure limit for a carcinogen. This compound is classified as a possible mutagen. There is no acceptable exposure limit for a mutagen. Section IX. Physical state @ 20°C Physical and Chemical Properties S o lid . (W h ite , C ry s ta l to C ry s ta llin e Solubility Not available. Powder.) Specific Gravity Molecular Weight 1.332 (water=1) 110.11 Partition Coefficient Log K ow : 0.59 Boiling Point 285°C (545°F) Vapor Pressure 1 mmHg @ 132°C Melting Point 171°C (339.8°F) Vapor Density 3.81 (Air = 1) Not available. Volatility Not available. Not available. Odor Not available. Not available. Taste Not available. Refractive Index Critical Temperature Viscosity Continued on Next Page Printed 2/6/2007. Emergency phone number (800) 424-9300 H0186 Section X. Stability Conditions of Instability Incompatibilities Section XI. RTECS Number Routes of Exposure Toxicity Data Hydroquinone Stability and Reactivity Data This material is stable if stored under proper conditions. (See Section VII for instructions) Avoid excessive heat and light. Reactive with strong oxidizing agents, strong alkalis (bases). Toxicological Information MX3500000 Eye Contact. Ingestion. Inhalation. Rat LD 50 Mouse LD Chronic Toxic Effects Page 3 (oral) 302 mg/kg 50 (oral) 245 mg/kg Rat LD 50 (intraperitoneal) 170 mg/kg Rat LD 50 (intravenous) 115 mg/kg CARCINOGENIC EFFECTS : Carcinogenic by RTECS criteria. MUTAGENIC EFFECTS : Not available. TERATOGENIC EFFECTS : Tumorigenic Effects. Rat TDLo Oral 12875 mg/kg/103 weeks intermittent TOXIC Effects: Tumorigenic - Carcinogenic by RTECS criteria Blood - Leukemia Rat TDLo Oral 25750 mg/kg/2 years continuous TOXIC Effects: Tumorigenic - Carcinogenic by RTECS criteria Blood - Leukemia Rat TDLo Oral 174720 mg/kg/26 weeks continuous TOXIC Effects: Tumorigenic - Carcinogenic by RTECS criteria Lung, Thorax, or Respiration - Tumors Liver - Tumors DEVELOPMENTAL TOXICITY : Reproductive Effects. Rat TDLo Oral 667 mg/kg, female 11 days of pregnancy TOXIC Effects: Effects on Fertility - Post implantation mortality Rat TDLo Subcutaneous 550 mg/kg, female 11 days prior to mating TOXIC Effects: Maternal Effects - Menstrual cycle changes or disorders TDLo Subcutaneous 5100 mg/kg, male 51 days prior to mating TOXIC Effects: Paternal Effects - Testes, epididymis, sper duct Paternal Effects - Prostate, seminal vessicale, Cowper's gland, accessory glands Effects on Fertility - Male fertility index Acute Toxic Effects T o x ic if in g e s t e d o r in h a le d . A v o id p r o lo n g e d c o n t a c t w it h t h is m a t e r ia l. O v e r e x p o s u r e m a y r e s u lt in s e r io u s illn e s s o r death. Ir r it a t in g t o e y e s a n d s k in o n c o n t a c t . In h a la t io n c a u s e s ir r it a t io n o f t h e lu n g s a n d r e s p ir a t o r y s y s t e m . t h e e y e is c h a r a c t e r iz e d b y r e d n e s s , w a t e r in g , a n d it c h in g . In f la m m a t io n o f S k in in f la m m a t io n is c h a r a c t e r iz e d b y it c h in g , s c a lin g , reddening, or, occasionally, blistering. Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound. Section XII. Ecotoxicity Environmental Fate Ecological Information Not available. H y d r o q u in o n e is b o t h a n a t u r a l a n d a n a n t h r o p o g e n ic c o m p o u n d . It m a y b e r e le a s e d t o t h e e n v ir o n m e n t a s a f u g it iv e e m is s io n d u r in g it s p r o d u c t io n , f o r m u la t io n , a n d u s e , a s a c h e m ic a l in t e r m e d ia t e , p h o t o g r a p h ic c h e m ic a l, a n d s t a b iliz e r . If r e le a s e d to s o il, h y d r o q u in o n e m a y b io d e g r a d e u n d e r a e r o b ic c o n d itio n s . It m a y a ls o b e r e m o v e d fr o m s o il b y o x id a t io n p r o c e s s e s o r b y d ir e c t p h o t o ly s is o n t h e s u r f a c e . V o la t iliz a t io n o f h y d r o q u in o n e f r o m e it h e r m o is t o r d r y s o il is n o t e x p e c t e d t o o c c u r t o a n y s ig n if ic a n t e x t e n t . H y d r o q u in o n e s h o u ld h a v e h ig h t o v e r y h ig h m o b ilit y in s o il. If r e le a s e d t o w a t e r , h y d r o q u in o n e m a y d e g r a d e u n d e r b o t h a e r o b ic a n d a n a e r o b ic c o n d it io n s . B io c o n c e n t r a t io n in f is h a n d a q u a t ic o r g a n is m s is n o t e x p e c t e d t o b e a n im p o r t a n t f a t e p r o c e s s , n o r w ill it a d s o r b t o s e d im e n t a n d s u s p e n d e d o r g a n ic m a t t e r . H y d r o q u in o n e w ill u n d e r g o d ir e c t p h o to ly s is in w a te r , a n d it m a y b e d e g r a d e d in w a te r b y o x id a tiv e p r o c e s s e s . V o la t iliz a t io n o f h y d r o q u in o n e f r o m w a t e r t o t h e a t m o s p h e r e w ill b e t o o s lo w t o b e e n v ir o n m e n t a lly im p o r t a n t . If r e le a s e d t o t h e a t m o s p h e r e , h y d r o q u in o n e w ill u n d e r g o d ir e c t p h o t o c h e m ic a l d e g r a d a t io n . It m a y u n d e r g o a t m o s p h e r ic r e m o v a l b y t h e r e a c t io n w it h p h o t o c h e m ic a lly p r o d u c e d h y d r o x y l r a d ic a ls a t a n e s t im a t e d h a lf - lif e o f 1 6 .8 h r s . H y d r o q u in o n e m a y a ls o b e r e m o v e d f r o m t h e a t m o s p h e r e b y w e t d e p o s it io n p r o c e s s e s . O c c u p a t io n a l e x p o s u r e t o h y d r o q u in o n e m a y o c c u r by dermal contact. Members of the general population who develop their own film may be exposed to hydroquinone. Section XIII. Waste Disposal Disposal Considerations R e c y c le t o p r o c e s s , if p o s s ib le . C o n s u lt y o u r lo c a l r e g io n a l a u t h o r it ie s . Y o u m a y b e a b le t o d is s o lv e o r m ix m a t e r ia l w it h a c o m b u s t ib le s o lv e n t a n d b u r n in a c h e m ic a l in c in e r a t o r e q u ip p e d w it h a n a f t e r b u r n e r a n d s c r u b b e r s y s t e m . O b s e r v e a ll federal, state and local regulations when disposing of the substance. Continued on Next Page Printed 2/6/2007. Emergency phone number (800) 424-9300 H0186 Section XIV. DOT Classification Hydroquinone Page 4 Transport Information Not a DOT controlled material (United States). PIN Number Not available. Proper Shipping Name Not available. Packing Group (PG) Not available. DOT Pictograms Section XV. TSCA Chemical Inventory (EPA) WHMIS Classification (Canada) EINECS Number (EEC) EEC Risk Statements Other Regulatory Information and Pictograms This compound is ON the EPA Toxic Substances Control Act (TSCA) inventory list. On DSL 204-617-8 R23/24/25- Toxic by inhalation, in contact with skin and if swallowed. R36/37/38- Irritating to eyes, respiratory system and skin. R45- May cause cancer. R46- May cause heritable genetic damage. R47- May cause birth defects. R50- Very toxic to aquatic organisms. Japanese Regulatory Data Section XVI. ENCS No. 3-543 Other Information Version 1.0 Validated on 2/6/2007. Printed 2/6/2007. Notice to Reader TCI laboratory chemicals are for research purposes only and are NOT intended for use as drugs, food additives, households, or pesticides. The information herein is believed to be correct, but does not claim to be all inclusive and should be used only as a guide. Neither the above named supplier nor any of its subsidiaries assumes any liability whatsoever for the accuracy or completeness of the information contained herein. Final determination of suitability of any material is the sole responsibility of the user. All chemical reagents must be handled with the recognition that their chemical, physiological, toxicological, and hazardous properties have not been fully investigated or determined. All chemical reagents should be handled only by individuals who are familiar with their potential hazards and who have been fully trained in proper safety, laboratory, and chemical handling procedures. Although certain hazards are described herein, we can not guarantee that these are the only hazards which exist. Our MSDS sheets are based only on data available at the time of shipping and are subject to change without notice as new information is obtained. Avoid long storage periods since the product is subject to degradation with age and may become more dangerous or hazardous. It is the responsibility of the user to request updated MSDS sheets for products that are stored for extended periods. Disposal of unused product must be undertaken by qualified personnel who are knowledgeable in all applicable regulations and follow all pertinent safety precautions including the use of appropriate protective equipment (e.g. protective goggles, protective clothing, breathing equipment, facial mask, fume hood). For proper handling and disposal, always comply with federal, state, and local regulations. Printed 2/6/2007.