Farhad Hafezi, M.D, Ph.D. Curriculum vitae Academic degree: Professor and Chair of Ophthalmology, University of Geneva, Switzerland and Clinical Professor of Ophthalmology, Doheny Eye Institute, USC, Los Angeles, USA University Eye Clinic, Rue Alcide Jentzer 22, 1211 Geneva, Switzerland November 1, 1967 Swiss Work address: Date of birth: Nationality: PROFESSIONAL RECOGNITION Medical Sixteen national and international awards, prizes and distinguished lectures in ophthalmology including the 2014 ARVO Foundation / Carl Camras Translational Research Award, the Jules Francois prize of the Belgian Ophthalmological Society, highest award for ophthalmology in Belgium and the Alfred Vogt prize of the Swiss Ophthalmological Society, highest award for ophthalmology in Switzerland. 1995 - present. Innovation Innovation awards of the University of Geneva, of the Geneva University Hospitals and from VentureKick Stage 1 for a new cross-linking technology. 2013. CONTRIBUTION TO THE SCIENTIFIC LITERATURE 1994 - ongoing Peer-reviewed primary publications, including "Nature Medicine" and "Nature Genetics": Case reports, reviews and book chapters: 64 54 h -index: Cumulative impact factor (ISI 2012): 31 332 Total cites: > 3'200 EDITORIAL ACTIVITIES Associate Editor Journal of Refractive Surgery Editorial Board Member Translational Vision Science and Technology (TVST), Iranian Journal of Ophthalmology, The International Journal of Keratoconus and Ectatic Corneal Disease Ten SELECTED PUBLICATIONS 1. Hafezi F, Steinbach JP, Marti A, Munz K, Wang ZQ, Wagner EF, Aguzzi A, Reme CE. The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo. Nat Med. 1997. 3(3): 346-9 2. Fleischmann A, Hafezi F, Elliott C, Reme CE, Ruther U, Wagner EF. Fra-1 replaces c-Fos-dependent functions in mice. Genes Dev. 2000. 14(21): 2695-700 3. Grimm C, Wenzel A, Hafezi F, Yu S, Redmond TM, Reme CE. Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration. Nat Genet. 2000. 25(1): 63-6 4. Hafezi F, Kanellopoulos J, Wiltfang R, Seiler T. Corneal collagen crosslinking with riboflavin and ultraviolet A to treat induced keratectasia after laser in situ keratomileusis. J Cataract Refract Surg. 2007. 33(12): 2035-40 5. Iseli HP, Thiel MA, Hafezi F, Kampmeier J, Seiler T. Ultraviolet A/riboflavin corneal cross-linking for infectious keratitis associated with corneal melts. Cornea. 2008. 27(5): 590-4 6. Hafezi F, Mrochen M, Iseli HP, Seiler T. Collagen crosslinking with ultraviolet-A and hypoosmolar riboflavin solution in thin corneas. J Cataract Refract Surg. 2009. 35(4): 621-4 7. Hafezi F, Dejica P, Majo F. Modified corneal collagen crosslinking reduces corneal oedema and diurnal visual fluctuations in Fuchs dystrophy. Br J Ophthalmol. 2010. 94(5): 660-1 8. Hafezi F, Koller T, Derhartunian V, Seiler T. Pregnancy may trigger late onset of keratectasia after LASIK. Journal of refractive surgery. 2012. 28(4): 242-3 9. Richoz O, Schutz JS, Pajic B, Coskunseven E, Hafezi F. Crosslinking for recurrent keratoconus. Ophthalmology. 2012. 119(4): 878-78 e2 10. Richoz O, Mavrakanas N, Pajic B, Hafezi F. Corneal Collagen Cross-Linking for Ectasia after LASIK and Photorefractive Keratectomy: Long-Term Results. Ophthalmology. 2013: LANGUAGES German (mother tongue). Fluent in english, french, polish (second mother tongue), persian BIOSKETCH Farhad Hafezi completed his medical studies and medical doctorate in Switzerland in 1992. From 1993 to 1994, he attended a twoyear course in experimental medicine and biology at the ETH Zurich (nowadays MSc Biology), followed by three years as a scientific post-doc in the Laboratory for Retinal Cell Biology in Zurich, Switzerland. Here, his research focused on molecular mechanisms of retinal degeneration using light-induced photoreceptor damage in transgenic mice as an experimental model. He identifed he first gene that would completely inhibit light-induced retinal damage (Hafezi et al., Nature Medicine, 1997). Clinically, Prof. Hafezi focused on corneal and refractive laser surgery where he became a pioneer in the method of corneal collagen cross-linking (CXL). He was instrumental in building a private institute in Zurich, Switzerland called IROC where the CXL technology was clinically further developped and the UV-X device was constructed and CE certified. Based on IP generated in his team at the University of Geneva, a spin-oﬀ company was launched in early 2013: EMAGine SA focuses on new modlaities to treat corneal infection. His PhD thesis from the Erasmus University of Rotterdam was on the management of complications in refractive laser surgery. In 2010, Prof. Hafezi has been appointed Chair and Professor of Ophthalmology of the University Eye Clinic of Geneva in Switzerland. In 2012, the Faculty of the Keck School of Medicine at the University of Southern California (USC) Los Angeles (Doheny Eye Institute) has appointed Prof. Hafezi as Clinical Professor of Ophthalmology. INVOLVEMENT IN THE TECHNIQUE OF CORNEAL COLLAGEN CROSS-LINKING • International opinion leader in CXL, partner in the successful translation of CXL into clinical ophthalmology in 2002. • Co-founded IROC together with Michael Mrochen and Theo Seiler. IROC is the institute in Zurich, Switzerland that developed the first UV-X CXL device dominating the world market between 2003 and 2010. • Has published > 40 scientific manuscripts on CXL • Main author of the first descriptions of the use of modified CXL in iatrogenic keratectasia, in extremely thin corneas and in Fuchs dystrophy. • Co-initiated the international CXL congress that was successfully held 7 times to date and he is the head of the organizing committee of the 8th international congress, that will be held in Geneva in December 2012. • Founding member of the “Expert group on surgical options in the management of Keratoconus” of the European Society for Cataract and Refractive Surgery (ESCRS) and heads the CXL educational course of the ESCRS • Board member for the CXL courses of the International Society for Refractive Surgery (ISRS) and American Academy of Ophthalmology (AAO) • Editor of the textbook by Slack Inc "Corneal collagen cross-linking" (appeared in May 2013)