UCL Institute of Ophthalmology 12th International Symposium of the Blood-Brain Barrier 9th – 11th September 2009 Wednesday 9th September 14.00 – 18.00 Registration 15.00 – 18.00 Poster Session I 17.00 – 18.30 Reception 18.30 – 19.30 Keynote Lecture Prof. Elisabetta Dejana (IFOM, FIRC Institute of Molecular Oncology, Milan) ‘Endothelial cell to cell signalling in the development of the blood brain barrier’ UCL Institute of Ophthalmology 12th International Symposium of the Blood-Brain Barrier 9th – 11th September 2009 Thursday 10th September Pathology & Disease 09.00 – 09.30 Gregory del Zoppo (University of Washington, Seattle, USA) ‘The roles of matrix adhesion receptor-matrix interactions in cerebral permeability barrier integrity’ 09.30 – 09.50 C J MacMillan (Dalhousie University, Halifax, Canada) ‘In vivo effect of neutrophils on the BBB in an acute stroke model’ 09.50 – 10.20 Mireille Lerner-Natoli (IGF, CNRS Montpellier, France) ‘BBB and intractable epilepsy: the vicious circle of epileptogenesis and angiogenesis’ 10.20 – 10.40 Tea / Coffee 10.40 – 11.10 Berislav Zlokovic (University of Rochester, New York, USA) ‘The role of vascular mechanisms and BBB transport in Alzheimer’s disease’ 11.10 – 11.30 Silvia Fischer (Justus-Liebig-University, Giessen, Germany) ‘The role of extracellular RNA in inflammatory process’ UCL Institute of Ophthalmology 11.30 – 11.50 David Baker (Queen Mary University of London, UK) ‘Central nervous system exclusion of cannabinoids for the treatment of multiple sclerosis using the properties of the BBB’ 11.50 – 14.30 Lunch / Tea / Coffee Poster Session II Homeostasis 14.30 – 15.00 Marcus Fruttiger (UCL Institute of Ophthalmology, London, UK) ‘Vascular homeostasis and glial-vascular interactions’ 15.00 – 15.20 Hartwig Wolburg (University of Tübingen, Germany) ‘Reduction of astrocyte polarity indicates blood-brain barrier impairment in inflammation and brain tumour’ 15.20 – 15.50 Tom Davis (University of Arizona, Tuscon, USA) ‘Regulation of blood brain barrier integrity by TGF beta signalling’ 15.50 – 16.10 Omolara Ogunshola (University of Zürich, Switzerland) ‘Astrocyte and pericyte modulation of hypoxic / oxidative stress at the BBB’ 16.10 – 16.30 Joseph H McCarty (M D Anderson Cancer Center, Houston, USA) ‘β8 integrin regulates neurovascular development and homeostasis in the adult brain’ UCL Institute of Ophthalmology 16.30 – 17.00 Holger Gerhardt (London Research Institute, Cancer Research UK) ‘Angiogenesis - a team effort coordinated by Notch’ 17.00 – 17.30 Tea / Coffee Cell passage across the BBB/BRB I 17.30 – 18.00 Richard Ransohoff (Lerner Research Institute, Cleveland, USA) ‘Regulation of leukocyte chemokine receptors during transmigration across the BBB in vitro, under flow conditions’ 18.00 – 18.20 Danica Stanimirovic (Institute for Biological Sciences, Ottawa, Canada) ‘The interactome of human endothelial cells and TH17 lymphocytes: identification of novel molecular targets using proteomics and bioinformatics’ 18.20 – 18.50 Isabel Crane (University of Aberdeen, UK) ‘Leukocyte trafficking across the blood-retina barrier- an in vivo model’ 18.50 Close of Thursday session UCL Institute of Ophthalmology 12th International Symposium of the Blood-Brain Barrier 9th – 11th September 2009 Friday 11th September Cell passage across the BBB/BRB II 08.45 – 09.05 Chris Carman (Harvard Medical School, Boston, USA) ‘Novel ventral lamellipodia-like structures (VLS) initiate closure of trans-cellular pores and paracellular gaps after diapedesis’ 09.05 – 09.25 Caroline Coisne (Theodor Kocher Institute, Bern, Switzerland) ‘Dendritic cell traffic into the CNS during experimental autoimmune encephalomyelitis is mediated by alpha4 integrin’ 09.25 – 09.55 Alexandre Prat (University of Montreal, Canada) ‘Mechanisms of blood-brain barrier-dependent recruitment of immune cell to the CNS’ Cell biology of the BBB/BRB 09.55 – 10.25 Kyu-Won Kim (Seoul National University, South Korea) ‘BBB and vascular network stability of zebrafish’ 10.25 – 10.55 Sandrine Bourdoulous (Institut Cochin, Paris, France) ‘Molecular mechanism by which Neisseria meningitidis adhere to and translocate through endothelial brainbarriers to cause meningitis’ UCL Institute of Ophthalmology 10.55 – 11.15 Paul Fitzpatrick (Dublin City University, Ireland) ‘The role of the actin cytoskeletal adaptor protein LASP-1 in Rho-GTPase-induced changes to endothelial cell adhesion’ 11.15 – 13.25 Lunch / Tea / Coffee Poster Session III Transport across the BBB/BRB 13.25 – 13.45 Jeong Hun Kim (Seoul National University Hospital, Korea) ‘Decursin inhibits VEGF-mediated inner blood-retinal barrier breakdown by suppression of VEGFR2 activation’ 13.45 – 14.05 Christopher Watson (King’s College London, UK) ‘Distribution of the anti-trypanosomal drug, nifurtimox, in human and murine blood-brain barrier models’ 14.05 – 14.25 Matthew Campbell (Trinity College Dublin, Ireland) ‘An experimental platform for systemic drug delivery to the retina’ 14.25 – 14.45 Salvatore Cisternino (INSERM U705, Paris, France) ‘Reversible H+-antiporter mediates clonidine transport at the mouse blood-ocular barrier’ Junctions and BBB permeability 14.45 – 15.15 Michael Fromm (Institute of Clinical Physiology, Berlin, Germany) ‘Water across tight junctions - fact or fancy?’ UCL Institute of Ophthalmology 15.15 – 15.35 Jimmy Cording (Leibzig-Institute for Molecular Pharmacology, Berlin, Germany) ‘Analysis of interactions between heterophilic tight junction proteins’ 15.35 – 15.55 Tea / Coffee 15.55 – 16.25 Lorenza Gonzalez-Mariscal (Centre for Research and Advanced Studies, Mexico City, Mexico) ‘The nuclear exportation of ZO-2 is regulated by PKC phosphorylation’ 16.25 – 16.55 David Antonetti (Penn State College of Medicine, Hershey, USA) ‘Uncovering a role for occludin in the regulation of endothelial permeability’ 16.55 – 17.15 Anuska Andjelkovic (University of Michigan Medical School, Ann Arbor, USA) ‘Mechanism of the Junctional Adhesion Molecule-A redistribution under inflammatory conditions’ 17.15 – 17.35 Anny-Claude Luissint (Institut Cochin, Paris, France) ‘Identification of new claudin-5 partners involved in the regulation of tight junction integrity in human brain endothelial cells’ 17.35 Conference closing address 17.45 London bus tour 19.00 (onwards) Conference reception and dinner