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The Hospital for Sick Children
2015 Research Integrity Symposium
Avoiding and Resolving
Authorship Issues
How to Make More Published
Research Results True
Investigating Research Misconduct
and Promoting the Responsible
Conduct of Research, 1989-2015
Lorraine Ferris, PhD
John Ioannidis, PhD, MD
David E. Wright, PhD
Associate Vice-President
Research Oversight
and Compliance
University of Toronto
C. F. Rehnborg Professor
in Disease Prevention,
Professor of Medicine and
Professor of Health Research
and Policy, Stanford University
Former Director, U.S. Office of Research
Integrity, Department of Health &
Human Services and Professor Emeritus,
Department of Community
Sustainability, Michigan State University
Monday April 27, 2015
1:00pm - 4:30pm
Peter Gilgan Centre for Research & Learning
686 Bay Street (North West corner Bay & Elm Streets)
Robert B. Salter Auditorium, 2nd Floor
All are welcome! No cost to attend.
Registration & Agenda at http://www.cvent.com/d/xrql60
Videoconference of Symposium available for Ontario Telemedicine
Network (OTN) members. Event will also be webcast.
Visit event website for more information.
SOCRA Members: This event offers 3.5 hours of CE credit.
Visit event website for information about how to obtain a certificate of attendance.
The Hospital for Sick Children
2015 Research Integrity Symposium
Monday April 27, 2015
1:00pm – 4:30pm
Peter Gilgan Centre for Research & Learning
Robert B. Salter Auditorium, 2nd Floor
1:00pm – 1:05pm
1:05pm – 2:05pm
2:05pm – 3:05pm
Janet Rossant, PhD
Chief of Research, Hospital for Sick Children
Welcome and Opening Remarks
Investigating Research Misconduct and
Promoting the Responsible Conduct of
Research, 1989-2015: An Evaluation
Avoiding and Resolving Authorship Issues
David E. Wright, PhD
Former Director, U.S. Office of Research Integrity, Department of Health and Human
Services; Professor Emeritus, Department of Community Sustainability, Michigan State
University
*To be introduced by David Bazett-Jones, Senior Scientist and former Research Integrity
Advisor, Hospital for Sick Children
Lorraine Ferris, PhD, C. Psych, LL.M. (ADR), LL.M. (Admin Law)*
Associate Vice-President, Research (Oversight and Compliance), University of Toronto;
and, President, World Association of Medical Editors
*To be introduced by James Ellis, Research Integrity Advisor, Hospital for Sick Children
Break - Light refreshments will be served in the Gallery (2nd Floor)
3:05pm – 3:30pm
3:30pm – 4:30pm
3:05pm – 3:10pm - attendees exit the Auditorium and make their way to the Gallery
3:25pm-3:30pm – attendees exit the Gallery and return to the Auditorium
How to Make More Published Research True
John P.A. Ioannidis, MD, DSc*
C. F. Rehnborg Chair in Disease Prevention; Professor of Medicine, of Health Research
and Policy, and of Statistics, Stanford University
*To be introduced by Martin Offringa, Program Head and Senior Scientist, Child Health
Evaluative Sciences Program
4:30pm – 4:35pm
Closing Remarks
James Ellis, PhD
Research Integrity Advisor, Hospital for Sick Children
David E. Wright, PhD
Former Director, Office of Research Integrity (ORI), U.S. Department of Health and Human
Professor Emeritus, Department of Community Sustainability, Michigan State University
Biography
Dr. Wright is a former Director, Office of Research Integrity (ORI), U.S. Department of Health and Human
Services and Professor Emeritus, Department of Community Sustainability, Michigan State University (MSU).
Dr. Wright received his undergraduate degree from Princeton University and his doctoral degree in American
Studies from MSU.
From 1993-2004, Dr. Wright served as MSU’s Assistant Vice President for Research Ethics and Standards, as
well as its Intellectual Integrity Officer, overseeing most of MSU’s research regulatory compliance activity. He
also chaired the University’s Committee on Research Involving Human Subjects for 11 years. From 20052011 Dr. Wright was Professor and Chairperson of MSU’s Department of Community Sustainability where he
taught and wrote on the history of science and technology and the responsible conduct of research.
Dr. Wright served as an expert consultant to ORI from 2001 until 2011, working with both the Division of
Investigative Oversight and the Division of Education and Integrity. In that capacity he was the architect of
the RIO Boot Camp program.
Dr. Wright has served as a consultant for research integrity, regulatory compliance, accreditation and related
issues for more than 20 higher education and research institutions in the past 10 years.
Title:
Investigating Research Misconduct and Promoting the Responsible Conduct of Research, 1989-2015: An
Evaluation
Abstract
The committing and detecting of research misconduct has changed substantially since the first U.S.
regulations first took effect in the late 1980s--changes driven largely by technological innovation, particularly
by the internet since the mid-1990s. It is, in short, a technological “arms race” that now takes place in a
global research culture. Respondents have, on balance, become more aggressive deploying many of the
defensive strategies used by white collar criminal defendants, chief among them delay and obstruction of the
investigative and adjudicative processes, counter-allegations against accusers and others, attacks against the
integrity of those administering the investigative process, and the manufacture of exculpatory witnesses and
evidence. Because we still do not know how common research misconduct is, it is hard to evaluate our
success in detecting and prosecuting it. Similarly, attempts to prevent research misconduct through
education in what has become known as the responsible conduct of research have never been rigorously
evaluated. The results of preliminary evaluations are not particularly encouraging. This situation challenges
research institutions, granting agencies, scientific journals and the research community as a whole to
reevaluate current approaches. While research misconduct, like crime, may always be with us, there are
some notable best practices and policies emerging among leading journals, institutions, and regulators.
Learning Objectives
1. Best tools and procedures for investigating misconduct
2. Best practices for research integrity officers in handling difficult respondents
3. Best strategies for preventing research misconduct
Lorraine Ferris, PhD. C. Psych, LL.M. (ADR), LL.M. (Admin Law)
Associate Vice-President, Research (Oversight and Compliance), University of Toronto; and,
President, World Association of Medical Editors
Biography
Professor Ferris is the University of Toronto’s Associate Vice-President, Research (Oversight and Compliance).
In this role she deals with research integrity and research misconduct matters as well as overseeing the
Research Office of Compliance and Oversight which includes research ethics, legal services and financial
reporting and audit.
Tenured in the Dalla Lana School of Public Health, Professor Ferris has a PhD in psychology, is registered to
practice and has two masters of laws degrees. She is a Senior Scientist at the Institute for Clinical Evaluative
Sciences.
Professor Ferris is the President, World Association of Medical Editors (WAME) which includes more than
1915 members, representing more than 1000 journals, from 92 countries.
Title:
Avoiding and Resolving Authorship Issues
Abstract:
This presentation will focus on authorship practices and conventions as well as on authorship disputes and
“authorship abuses”. Topics will include what it means to make a “significant contribution” and to take
“public responsibility”; authorship order; ghost, guest, gift and denied authorship; and preventing authorship
disputes. Case scenarios will be used to illustrate points, some of which are those being addressed by
biomedical journal editors.
Learning Objectives:
At the end of the talk, participants will:
1. Be able to identify common authorship issues
2. Know of some practical ways to avoid such issues
3. Know of some options to resolve the issues if they arise
John Ioannidis, MD, DSc
C. F. Rehnborg Chair in Disease Prevention; Professor of Medicine, of Health Research and
Policy, and of Statistics, Stanford University
Biography
Dr. Ioannidis holds the C.F. Rehnborg Chair in Disease Prevention at Stanford University and is Professor of
Medicine, Professor of Health Research and Policy, and Director of the Stanford Prevention Research Center
at Stanford University School of Medicine; Professor of Statistics (by courtesy) at Stanford University School
of Humanities and Sciences; and one of two Directors of the Meta-Research Innovation Center at Stanford.
Born in New York and raised in Athens, Greece, Dr. Ioannidis completed medical school at the University of
Athens and received a doctorate in biopathology from the same institution. He later trained at Harvard and
Tufts specializing in Internal Medicine and Infectious Diseases. He has worked and served in various
capacities at universities, institutes, and boards including the National Institutes of Health, Johns Hopkins and
Tufts. He has received numerous awards and accolades, including being named “one of the most influential
scientists alive” by The Atlantic, which also awarded him the Brave Thinker scientist honor in 2010.
Dr. Ioannidis’ PLoS Medicine paper on “Why most Published Research Findings are False,” has been the mostaccessed article in the history of Public Library of Science exceeding 1.2 million hits. Ioannidis remains one of
the top-cited scientists worldwide and continues to create discussions about the process of research.
Title:
How to Make More Published Research True
Abstract:
Many empirical studies have shown substantial problems in the replication, re-analysis, or reproducibility of
published research in diverse fields of biomedicine and beyond. This non-reproducibility causes a threat to
the trust and credibility of research, but it also opens new possibilities for improving research practices. Some
solutions have already been applied successfully in specific fields, while others are still speculative. The talk
will discuss some of the proposed solutions, including the adoption of large-scale collaborative research;
promotion of the replication culture; registration; sharing; adoption of reproducibility practices; use of better
statistical methods; standardization of definitions and analyses; more appropriate (usually more stringent)
statistical thresholds; and improvement in study design standards, peer review, reporting and dissemination
of research, and training of the scientific workforce. Many of these solutions have a strong interface with the
current and future reward and incentive system for research.
Learning Objectives:
Coming soon!