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ASMS 2015 Scientific Presentations
Oral Presentations
Monday, June 1
9:10-9:30 AM, Hall 5
Hybrid Optical Microscope/Laser Ablation Liquid Capture Mass Spectrometry System Providing Co-registered Optical Bright Field,
Fluorescence and Mass Spectral Images
Gary J. Van Berkel*1; John Cahill1; Vilmos Kertesz1; Thomas Covey2; Julian Burke3
1
2
3
Oak Ridge National Laboratory; SCIEX; Leica Microsystems Group, United Kingdom
9:50-10:10 AM, Ballroom 220/221
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Untargeted and Rapid Detection and Characterization of Modified Monoclonal Antibodies Using LC-TripleTOF and Multivariate
Statistical Analysis
1
2
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2
1
1
Ming Yao* ; Xu Wang ; Weiping Zhao ; Li Ma ; John T. Mehl ; Yi Zhang ; Sahana Mollah ; W. Griff Humphreys ; Mingshe Zhu
1
2
Bristol-Myers Squibb; SCIEX
Tuesday, June 2
9:10-9:30 AM, Hall 5
A W-geometry Ortho-TOF MS with High Resolution and Up To 100% Duty Cycle for MS/MS
1
1
2
Samuel Merenbloom* ; Nic Bloomfield ; Alexandre Loboda ; Igor Chernushevich
1
SCIEX; 2Fluidigm Canada Inc.
3:10-3:30 PM, Room 130/132
1
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Multi Laboratory Reproducibility and Performance of SWATH Acquisition for Proteomic Analyses
1
2
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3
3
Christie Hunter* ; Ben Collins ; Yansheng Liu ; Stefani Thomas ; Dan Chan ; Hui Zhang3; Samuel Bader4; Robert Moritz4; Birgit Schilling5; Bradford Gibson5; Christoph
Krisp6; Mark Molloy7; Guixue Hou8; Liang Lin8; Siqi Liu8; Mio Hirayama9; Sumio Ohtsuki9; Nathalie Selevsek10; Ralph Schlapbach10; Shin-Cheng Tzeng11; Jason Held11;
Brett Larsen12; Anne-Claude Gingras12; Ruedi Aebersold2
1
SCIEX; 2ETH Zurich, Switzerland; 3Johns Hopkins University; 4Inst Systems Biology; 5Buck Institute for Research on Aging; 6Australian Proteome Analysis Facility,
Australia; 7Macquarie University, Australia; 8BGI, China; 9Univ. Kumamoto, Japan; 10FGCZ, Univ. Zurich, Switzerland; 11Washington University; 12LTRI
Wednesday, June 3
2:30-2:50 PM, Ballroom 220/221
Comprehensive characterization of three IgG forms using CESI-MS
Bryan Fonslow*1; Olga V. Friese2; K. Steven Cook2
1
2
SCIEX; Pfizer
4:10-4:30 PM, Room 130/132
'How to Recover from a Bad Day' Data Processing Tolerant to Experimental Errors
Amandine Boudreau*; Gordana Ivosev; Vlad Savchenko; CJ Baker; Suya Liu; Stephen A. Tate
SCIEX
Thursday, June 4
10:10-10:30 AM, Room 120/127
Analysis of Proteins, Protein Complexes and Proteomes Under Non-Denaturing Conditions Using Sheathless Capillary
Electrophoresis Coupled with Native Mass Spectrometry
Alexander R. Ivanov*1 ; Rosa Viner2; Marcia R. Santos3; Arseniy M. Belov1; Chitra K. Ratnayake3; David M. Horn2; Marshall W. Bern4; Barry L. Karger1
1
Barnett Inst., Northeastern University; 2ThermoFisher Scientific; 3SCIEX; 4Protein Metrics
10:10-10:30 AM, Ballroom 220/221
Application of Differential Mobility Spectrometry Coupled with Multiple Ion Monitoring for Quantitation of Peptides Not Suited for
MRM Analysis
1
2
2
Yuan-Qing Xia* ; Eugene Ciccimaro, Jr. ; Naiyu Zheng ; Mingshe Zhu
1
SCIEX; 2Bristol-Myers Squibb Company
2
3:30-3:50 PM, Ballroom 220/221
Detection and Quantitation of Insulin Analogues by Differential Mobility Coupled to Mass Spectrometry
J.C. Yves LeBlanc*; Brad Schneider; J. Larry Campbell
SCIEX
1
ASMS 2015 Scientific Presentations
Poster Presentations (all posters are located in the Poster/Exhibit Hall, 10:30 AM-2:30 PM)
Monday, June 1
#100
Identification of Biologic Catabolites Using a Q-ToF and Software-Driven Workflow
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2
2
Yilin Feng* ; Panos Hatsis ; Suma Ramagiri ; Eva Duchoslav ; Lyle Burton ; Jimmy Flarakos
1
2
Novartis Institutes for Biomedical Research; SCIEX
1
#106
A Method for Improved LC-MS/MS Peak Integration by Using Multiple Traces and Peak Modeling
1
2
2
Richard King* ; John Gibbons ; Lyle Burton ; Gordana Ivosev
1
2
PharmaCadence Analytical Services; SCIEX
2
#108
Low-resolution and High-transmission Differential Mobility Spectrometer as a Pre-filter for ESI-MS Systems
Yang Kang*; Bradley B. Schneider; Thomas R. Covey
SCIEX
#110
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SelexION Mobility Separation of Leukotriene Isomers
Cyrus Papan*1; Sebastian Fabritz1; Martin Giera2
1
SCIEX Germany; 2Leids Universitair Medisch Centrum, Netherlands
#113
Differential Mobility Separation Prior to Data-Dependent and Data-Independent MS Analysis of Complex Human Proteomics
Samples
Sabine Amon*1; Stephen A. Tate2 ; Ruedi Aebersold1,3
1
Institute of Molecular Systems Biology, ETH Zurich, Switzerland; 2SCIEX; 3Faculty of Science, University of Zurich, Switzerland
#117
Using Differential Mobility Spectrometry for the Detection of Intramolecular Hydrogen Bonding
J. Larry Campbell*1; Chang Liu1; J.C. Yves LeBlanc1; Gilles H. Goetz2; Jefry Shields2; John Janiszewski2; Ahdia Anwar3; W. Scott Hopkins3
1
SCIEX; 2Pfizer Inc.; 3University of Waterloo
#119
Differential Mobility Spectrometry Analysis of Glycans and Glycopeptides
Chang Liu; J.C. Yves LeBlanc; J. Larry Campbell; Tim L. Hoffman*
SCIEX
#123
Use of Differential Mobility Spectrometry-Hydrogen Deuterium Exchange (DMS-HDX) with Optimised Modifier Gas to Investigate
Solution-phase Protein Conformational Stability
Shaolong Zhu*1; J. Larry Campbell2; J.C. Yves LeBlanc2; Derek Wilson1
1
York University; 2SCIEX
#228
Liquid Chromatography Mass Spectrometry Based Workflows for Herbal Product Analysis
Manoj Pillai*; Akanksha Singh
SCIEX India
#285
Differential Mobility Spectrometry as a Measure of Physicochemical Properties Related to in vitro Absorption (Permeability,
Solubility and Lipophilicity)
Jefry Shields*1; Chang Liu2; John Janiszewski1; Hui Zhang1; J. Larry Campbell2; J.C. Yves LeBlanc2
1
Pfizer Inc.;2SCIEX
#298
Evaluation of a High Resolution Accurate Mass Instrument for Discovery Microsomal Clearance and Metabolite ID Analysis
Mustafa Varoglu*1; Lieu Nguyen1; Xiaowei He1; Keith Goodman2
1
Cubist Pharmaceuticals; 2SCIEX
#341
Targeted Metabolic Profiling Using High-resolution Accurate Mass Database to Identify and Confirm Potential Biomarkers in Rose
and Sunflower Plant Extracts
Jeffrey D. Miller*1; Cyrus Papan2; Jens Pfannstiel3; Iris Klaiber3; Baljit K. Ubhi1; Fadi Abdi1; Tobias Bruderer4; Emmanuel Varesio4; Gerard Hopfgartner4
1
SCIEX; 2SCIEX Germany; 3Universität Hohenheim, Germany; 4University of Geneva, Switzerland
2
ASMS 2015 Scientific Presentations
Poster Presentations (all posters are located in the Poster/Exhibit Hall, 10:30 AM-2:30 PM)
Monday, June 1 (continued)
#389
Quantitative and Qualitative Metabolomics for the Investigation of Intracellular Metabolism
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Brigitte Simons* ; Baljit Ubhi ; Douglas McCloskey
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2
SCIEX; University of California San Diego
#405
The Use of Capillary Electrophoresis Coupled to Mass Spectrometry (CESI-MS) for Quantitation of Nucleotides and Nucleosides
with Minimal Sample Preparation
Jose-Luis Gallegos-Perez
SCIEX
#493
The Application of Capillary Electrospray Ionization with Negative Ion Electrospray Ionization to the Analysis of Plant Metabolites
1
2
Stephen J. Lock* ; Edna Betgovargez
1
SCIEX United Kingdom; 2SCIEX
#534
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Comprehensive Relative Quantification of the Cytochromes P450 Using SWATH Acquisition
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Rosalind E. Jenkins ; Sibylle Heidelberger* ; Thomas Knapman ; Francesco L. Brancia ; Neil R. Kitteringham1; B. Kevin Park1
1
University of Liverpool, United Kingdom; 2SCIEX United Kingdom
#589
Characterization of Intact Prostate Specific Antigen (PSA) and Its Glycoforms by CESI-MS Under Native and Denaturing
Conditions
Marcia R. Santos*1; Chitra K. Ratnayake1; David M. Horn2; Barry L. Karger3; Alexander R. Ivanov3; Rosa I. Viner2
1
SCIEX; 2Thermo Fisher Scientific; 3Northeastern University
#596
High-Throughput Electron Capture Dissociation Mass Spectrometry in a Novel Branched Radio-Frequency Ion-Trap as a Platform
for Glycoproteomics
St John Skilton*; J.C. Yves LeBlanc; Takashi Baba; James Hager; J. Larry Campbell
SCIEX
Tuesday, June 2
#103
Comprehensive Characterization of Low Molecular Weight Heparins Using High Resolution Mass Spectrometry
Annu Uppal*; Dipankar Malakar; Faraz Rashid; Manoj Pillai
SCIEX India
#114
A Streamlined Workflow for the Profiling of Impurities Using High Resolution Accurate Mass Spectrometry
Jason Causon
SCIEX
#195
An Autonomous Workflow for Untargeted Metabolomics
Baljit Ubhi*1; Paul Benton2; Duane Rinehart2; Gary Siuzdak2
1
SCIEX; 2Scripps Center for Metabolomics & Mass Spec
#210
Effect of Mealybug Infestation on Grape Metabolomics
Shabeer TP Ahammed1; Amala Udayakumar1; Akanksha Singh*2; Manoj Pillai2
1
National Research Centre for Grapes, India; 2SCIEX India
#221
Comprehensive Analysis of in-vivo Metabolites Using MS/MS
Based on High Resolution Mass Spectrometry
ALL
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SWATH Acquisition and Online Information Dependent Analysis
Liang Li1; Xiaoyan Chen*1; Dafang Zhong1; Ting Liu2; Suma Ramagiri2; Cheng Yang2; Kerong Zhang2; Wei Cheng2
1
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China; 2SCIEX China
3
ASMS 2015 Scientific Presentations
Poster Presentations (all posters are located in the Poster/Exhibit Hall, 10:30 AM-2:30 PM)
Tuesday, June 2 (continued)
#226
Software-Aided Workflow for Investigation of Catabolic Degradation Products During Peptide Therapeutics Compound
Optimization
Eva Duchoslav*; Jinal Patel; Suma Ramagiri
SCIEX
#230
Tissue-engineered Long Term Hepatocyte Co-culture Model and Data Independent Mass Spectrometry Acquisition to Identify
Multi-generation Metabolites
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Yvonne Schaus ; Suma Ramagiri ; Gary Impey* ; Jack McGeehan ; Vince Zurawski
1
2
Hepregen; SCIEX
1
#242
A Novel Lipid Screening Platform Allowing a Complete Solution for Lipidomics Research
Alex Conner*1; Baljit K. Ubhi2; Eva Duchoslav2; Leo Wang2; Paul R.S. Baker2; Steven Watkins1
1
Lipomics; 2SCIEX
#245
Retinoic Acid Analysis with Differential Mobility Mass Spectrometry for Improved Selectivity and Sensitivity
Leo (Jinyuan) Wang1; Jace W. Jones2; Maureen A. Kane2; Paul R.S. Baker*1
1
SCIEX; 2University of Maryland, School of Pharmacy
#279
Automation of Calibration Curve Redaction for Absolute Quantitation by LC/MS
Lyle Burton*; Michael J. Y. Jarvis
SCIEX
#330
LC/MS/MS Analysis of Perfluoroalkyl Acids in Environmental Samples, Food Packaging Material and Food - A Migration and
Accumulation Study
Andre Schreiber*1; Liesl Krone2; KC Hyland1; Tom Biesenthal1; Tanya Gamble1; Chris Higgins3
1
2
3
SCIEX; Granbury, TX High School; Colorado School of Mines
#332
Quantitative Determination of Seven Fluorescent Whitening Agents Migration of Paper Cups by High Performance Liquid
Chromatography Tandem Mass Spectrometry
ZhiFeng Du1; XinDong Guo*2; JinFeng Huang2; LiJun Li1; WenHai Jin1; HuaFen Liu3; HuaiEn Zhu1
1
SCIEX China; 2National Centre for Quality Supervision, China; 3SCIEX
#396
In-line Separation by Capillary Electrophoresis Prior to Analysis by Top-down Mass Spectrometry Enables Sensitive
Characterization of Protein Complexes
Xuemei Han*1; Aaron Aslanian1; Bryan Fonslow1,2 ; Daniel McClatchy1; Beth Graczyk3; Trisha N. Davis3 ; John Yates1
1
The Scripps Research Institute; 2SCIEX; 3University of Washington
Wednesday, June 3
#70
A Sensitive and Selective LC/MS/MS Detection and Quantitation of Highly Polar Aminoglycosides Antibiotics in Honey Matrix
Neha Bhasin1; Prasanth Joseph1; Praveen Sharma1; Manoj Pillai1; Jianru Stahl-Zeng*2
1
SCIEX India; 2SCIEX Germany
#72
Targeted Multi Residue LC/MS/MS Method for Sulfonamides and Nitroimidazoles Antibiotics in Honey with LC/MS/MS
Neha Bhasin1; Prasanth Joseph1; Praveen Sharma1; Manoj Pillai1; Jens Dahlmann*2
1
SCIEX India; 2SCIEX Germany
#73
Method Development for Fake Lamb Meat Detection Using LC/MS/MS System
Lihai Guo*; Haiyan Cheng; Wenhai Jin; Huafen Liu
SCIEX China
4
ASMS 2015 Scientific Presentations
Poster Presentations (all posters are located in the Poster/Exhibit Hall, 10:30 AM-2:30 PM)
Wednesday, June 3 (continued)
#79
A New Approach for Low-level Quantification of Pesticide Residues in Fruits and Vegetables Using a Microflow-LC-ESI®
®
QTRAP /TripleTOF MS
Barbara Reichert1,2; Ionara Regina Pizzutti3; Ijon iHilda Costabeber4; Ana Uclas5; Sonia Herrera5; Amadeo R. Ferna¡ndez-Alba5 ; Jianru Stahl-Zeng6 ; Ashley Sage*6
1
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Department of Food Science and Technology, UFSM, Brazil; CAPES Foundation, Ministry of Education of Brazil; Center of Research and Analysis of Residues and
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Contaminan, Brazil; Department of Morphology, UFSM, Brazil; University of Almeria, Spain; SCIEX Germany
#80
Fast, Robust and Reliable Method for the Identification and Quantitation of Sildenafil Residue in Honey Using LC/MS/MS
Praveen Kumar Sharma*1; Neha Bhasin1; Prasanth Joseph1; Manoj Pillai1; Andre Schreiber2
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SCIEX India; SCIEX
#82
Development of a Cost Effective and Sensitive Method for the Analysis of Aflatoxin M1 in Milk Samples
Ajit Dua*1; Sanjivan Bahman1; S.S. Marwaha1; Prasanth Joseph2; Neha Bhasin2; Praveen Sharma2; Manoj Pillai2
1
Punjab Biotechnology Incubator, India; 2SCIEX India
#114
A Novel High-throughput Microflow UHPLC Method for LC/MS/MS Quantitation
Khaled S. Mriziq*; Witold Woroniecki; Remco Van Soest; David Neyer
SCIEX
#121
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Bioanalytical Quantitation Method for Analysis of 1,25-Dihydroxyvitamin D3 in Plasma Using Amplifex Reagent on SCIEX Triple
™
Quad 5500 LC/MS/MS System
Balu Dawkhar1; Abhas Tiwari1; B Suryanarayana1; Milind Bagul1; Rahul Baghla2; Anoop Kumar*2; Manoj Pillai2; Subhakar Dey3; Subhasish Purkayastha3
1
Raptim Research Limited, India; 2SCIEX India; 3SCIEX
#124
Highly Sensitive and Selective Bioanalytical Quantitation Method for Phytonadione Isomers in Human Plasma on SCIEX Triple
™
Quad 6500 System
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L. Ramalingam ; Jagadeesh Banda ; Shiv Prasad ; Rahul Baghla* ; Ch. Lakshmi Narayana ; Ch. Thirupathi ; Anoop Kumar ; Manoj Pillai
1
QPS Bioserve India Pvt Ltd, India; 2SCIEX India; 3Daicel Chiral Technologies (India) Pvt. Limited, India
2
#138
Evaluation of MRM vs HRMS for Bioanalytical Quantitation of Efavirenz in Human Plasma
Yogesh Modhave1; Pradnya Shahapure*1; Arshad Khuroo1; Anoop Kumar2; Manoj Pillai2
1
CPP, Ranbaxy Laboratories Limited, India; 2SCIEX India
#150
A Generic Approach for Absolute Quantitation of the Monoclonal Antibody in Human Serum Using Triple Quadrupole Mass
Spectrometry
Xiaoyun Peng*1; Huaizu Guo2; Qingcheng Guo2; Sheng Hou2; Ting Liu3; Ji Luo3; Cheng Yang3; Hua-fen Liu3; Wenhai Jin3; Wei Cheng3
1
School of Bioscience and Bioengineering, South China University of Technology, China; 2State Key Laboratory of Antibody Medicine, Key Laboratory of Cell
Engineering, China; 3SCIEX China
#246
Targeted Lipidomic Analysis of Eicosanoids
Baljit Ubhi1; Jason Causon2; Fadi Abdi*1; Michael Mihlan3; Romeo Ricci4
1
SCIEX; 2SCIEX United Kingdom; 3Institut de Génétique et de Biologie Moléculaire, France; 4IGBMC, INSERM, CNRS, Université de Strasbourg, France
#249
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QTRAP LC/MS/MS Workflow for Simultaneous Characterization and Quantitation of PEGylated Liposomal Drug Formulations
Sebastian Fabritz*1; Cyrus Papan1; Pol Harvengt2
1
SCIEX Germany; 2GSK Vaccines, Belgium
#257
EIEIO: Electron Ionization for Excitation of Ions from Organics for Near Complete Structural Characterization in Lipidomics
Takashi Baba*; J. Larry Campbell
SCIEX
#310
Deconvolution of MS/MS from Mixed Chemical Species
David Cox*; Gordana Ivosev; Lyle Burton; J.C. Yves LeBlanc
SCIEX
5
ASMS 2015 Scientific Presentations
Poster Presentations (all posters are located in the Poster/Exhibit Hall, 10:30 AM-2:30 PM)
Wednesday, June 3 (continued)
#316
®
Retention Time Independent SWATH Acquisition Scoring
Jamie Sherman*; Stephen A. Tate
SCIEX
#322
™
Improved Peptide Identification by ProteinPilot v5.0 Software Using Chimeric Spectra Detection
Dipankar Malakar*; Faraz Rashid; Manoj Pillai
SCIEX India
#353
Validation Studies of a Proteomics Normalization Standard Consisting of 1,000 Stable Isotope Labeled Peptides
Christopher Colangelo*1; Craig Dufresne2; Alexander R. Ivanov3; Gordana Ivosev4; David Hawke5; Antonius Koller6; Brendan Maclean7; Brett Phinney8; Kristie Rose9;
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Paul Rudnick ; Brian Searle ; Scott A. Shaffer
1
Primary Ion; 2Thermo Fisher Scientific; 3Barnett Inst., Northeastern University; 4SCIEX; 5UT- M.D. Anderson Cancer Center; 6Columbia University; 7Univ of Washington;
8
Univeristy of CA, Davis; 9Vanderbilt University; 10Spectragen Informatics; 11Proteome Software Inc.; 12University of Massachusetts Medical School
#375
Fast, Sensitive, Robust SPE-LC/MS/MS Method for Quantitation of Insulin Analogues in Clinical Research Studies
Lei Xiong1; Witold Woroniecki1; Rahul Baghla2; Suma Ramagiri1; Gary Impey1; Hua-Fen Liu*1
1
SCIEX; 2SCIEX India
#416
CESI-MS Analysis of Asparagine Deamidation and Aspartate Isomerization in Polypeptides
Bettina Sarg; Klaus Faserl; Herbert H. Lindner
Div. of Clin. Biochemistry, Biocenter Innsbruck, Austria
#420
The Effect of Ultra-low Flow on the Ionization of Biotherapeutics
Andras Guttman
SCIEX
#487
Enhancing Selectivity for the Analysis of Methyl Dienelone in Urine Samples by Differential Mobility Spectrometry
Prasanth Joseph*1; Sachin Dubey2; Shobha Ahi2; Neha Bhasin1; Praveen Sharma1; Manoj Pillai1; Alka Beotra2; Shila Jain2
1
SCIEX India; 2National Dope Testing Laboratory, JN Stadium Complex, India
#514
An Automated Sample Preparation System Based on the Mixing Driven by Oscillating Magnetic Fields
Chang Liu*1; Anne-Sophie Wavreille2; Jonathan Sidibe3; Gerard Hopfgartner3; Amar Rida2; J. Larry Campbell1; Don Arnold1; Tom Covey1
1
SCIEX; 2Spinomix, Switzerland; 3University of Geneva, Switzerland
#516
Optimization of Automated High Throughput Trypsin Digests for Highly Reproducible Peptide Map Analysis
Eric Johansen*; St John Skilton
SCIEX
#555
Understanding the Roles of Electronic and Steric Effects in Separating Isomers Using Differential Mobility Spectrometry
Chris J. Lock*1; J. Larry Campbell1; Chang Liu1; J.C. Yves LeBlanc1; Jefry Shields2; John Janiszewski2; Christian Ieritano3; Gene Ye3; Gillian Hawes3; Moaraj Hasan3; W.
3
Scott Hopkins
1
SCIEX; 2Pfizer; 3University of Waterloo
#663
Comprehensive Characterization of a Representative Antibody-Drug Conjugate by CESI-MS
Bryan Fonslow; Eric Johansen; Hans Dewald*
SCIEX
#677
Enhancing Characterization Antibody-based Biologic Using Differential Mobility and Mass Spectrometry
Tanya Gamble*; J.C. Yves LeBlanc; Eric Johansen; Suma Ramagiri
SCIEX
6
ASMS 2015 Scientific Presentations
Poster Presentations (all posters are located in the Poster/Exhibit Hall, 10:30 AM-2:30 PM)
Wednesday, June 3 (continued)
#679
Application of Data Independent Acquisition for Top-Down Characterization of IgG Light
Sahana Mollah*; Melanie Juba; Xu Wang
SCIEX
#682
A Universal Immunocapture-LC/MS/MS Workflow for Biological Compound Quantitation in Preclinical Studies
Lei Xiong*; Witold Woroniecki; Suma Ramagiri; Gary Impey; Hua-Fen Liu
SCIEX
Thursday, June 19
#175
Analysis of Methamphetamine and Its Metabolite, Amphetamine by Chiral CESI-MS
John Hudson*; Andras Guttman
SCIEX
#215
Rapid Identification of Major Constituents and Rats Metabolites of DanHong Injection Using a Hybrid Triple Quadrupole Linear Ion
Trap System
Huifen Zhou1; Shaoyun Chen1; Yuyan Zhang1; Haitong Wan1; Dandan Si*2; Xiaoyan Xu2; Ting Liu2; Huaidong Yu2; Wenhai Jin2
1
Zhejiang Chinese Medical University, China; 2SCIEX China
#239
Broad Profiling of Drug-Metabolizing Enzymes in Human Liver Microsome Using Variable Window Data-Independent Acquisition
Hui Zhang*1; Xu Wang1; Jianhua Liu1; Mary Piotrowski1; Sahana Mollah2; Sushmit Maitra2; John Janiszewski1
1
Pfizer, Inc.; 2SCIEX
#257
3
Separation of Plasma Vitamin D3 Metabolites Using MRM Technology
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Xi Chen* ; Loren Olson ; Mollah Sahana ; Kenneth Thummel ; Brian Phillips2
1
SCIEX; 2University of Washington
#290
SWATH Enables Precise Label-free Quantification on Proteome-scale
Qiang Huang1,2; Lu Yang1,2; Ji Luo*3; Lin Guo1,2; Zhiyuan Wang1,2; Xiangyun Yang1,2; Wenhai Jin3; Juanying Ye1,2; Bing Shan1; Yaoyang Zhang1,2
1
Interdisciplinary Research Center on Biology, China; 2Shanghai Institute of Organic Chemistry, China; 3SCIEX China
#348
An Immunocapture-LC/MS/MS Workflow for Adalimumab (Humira) and Infliximab (Remicade) Quantitation in Human Plasma
Witold Woroniecki*; Lei Xiong; Kelli Jonakin; Shaw Xia; Suma Ramagiri; Hua-Fen Liu
SCIEX
#351
Automated High Throughput Peptide and Protein MRM Optimization and On-Column HPLC Screening for Pharmaceutical Method
Development
Ian Moore*; Suma Ramagiri
SCIEX
#356
A Sensitive LC/MS/MS Method for Quantitation of Glucagon in Human Plasma
Witold Woroniecki; Lei Xiong; Kelli Jonakin; Rahul Baghla*; Suma Ramagiri; Hua-Fen Liu
SCIEX
#401
Dual Channel Microflow LC/MS: Investigations of High Sensitivity and High Throughput
David Neyer*; Remco van Soest; Khaled Mriziq
SCIEX
#403
Ultrafast, Highly Sensitive microLC/MS/MS for Peptide Quantitation in Highly Targeted Assays
Remco van Soest*; Christie Hunter
SCIEX
7
ASMS 2015 Scientific Presentations
Poster Presentations (all posters are located in the Poster/Exhibit Hall, 10:30 AM-2:30 PM)
Thursday, June 4 (continued)
#508
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Analysis of Non-deglycosylated Antibody-Drug-Conjugates by TripleTOF High Resolution Quadrupole-Time-Of-Flight Instrument
and Effective Reconstruction Software
Milla-Riina Neffling*1; Bruno Genet2; David Bugnazet2; Eric Lacassie2; Justin Blethrow3; Eric Johansen3
1
2
3
SCIEX United Kingdom; Sanofi-Vitry Biologics SCP/ Analytics, France; SCIEX
#599
®
Ultra-sensitive Host Cell Protein Quantification Using CESI-SWATH Acquisition MS
Edna Betgovargez*; Bryan Fonslow; Eric Johansen
SCIEX
#610
A Robust and Automated Generic Sample Extraction Method for Quantifying Antibody Therapeutics in Biological Matrices
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2
1
Suma Ramagiri* ; Mike Rosenblatt ; Ian Moore ; Nidhi Nath ; Kevin Cook ; Gary Impey
1
SCIEX; 2Promega Corporation
#613
Detection and Quantification of Low-abundant GDF-11 in Nondepleted Biofluid Protein Complexity Using LC/MS/MS and
LC/MS/MS/MS Analysis
Liming Peng*1; Srinivasan Krishnan2; Xiaohong Chen1; Shalender Bhasin1
1
Brigham and Women's Hospital; 2SCIEX
#618
Single Analytical Tool for Establishing Biosimilarity: A Biosimilar Case Study
Faraz Rashid*; Annu Uppal; Dipankar Malakar; Manoj Pillai
SCIEX India
#622
Disulfide Bond Mapping of Biosimilar Infliximab
Annu Uppal1; Milla Neffling2; Steve Taylor*2; Dipankar Malakar1; Faraz Rashid1; Manoj Pillai1
1
SCIEX India; 2SCIEX United Kingdom
#624
Complete Primary Structure and Biosimilarity Assessment of Monoclonal Antibodies in a Single Analysis Using Transient
Isotachophoresis Capillary Electrophoresis-Tandem Mass Spectrometry
Rabah Gahoual1,3; Jean-Marc Busnel4; Alain Beck2; Yannis-Nicolas Francois1; Emmanuelle Leize-Wagner1
1
LSMIS, UMR 7140, University of Strasbourg, France; 2Centre d’immunologie Pierre Fabre, France; 3University of Amsterdam, Netherlands; 4Beckman Coulter Inc.,
France
8