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Phylogenetics and Networks for Generalised HIV Epidemics in Africa
Satellite Workshop:
Phylogenetic Method
Comparison
14.00 – 17.00 Saturday, 16th May, 2015
Hungarian Academy of Sciences, Budapest
CHAIRED BY CHRISTOPHE FRASER AND ANDREW LEIGH BROWN
Sponsored by the PANGEA-HIV Consortium in conjunction with the 22 n d
International Workshop on HIV Dynamics and Evolution
PANGEA-­‐HIV (Phylogenies And Networks for Generalized Epidemics in Africa) is a major new initiative funded by the Bill and Melinda Gates Foundation primarily to generate a large volume of sequence data from African HIV cohorts to facilitate the phylodynamic characterization of generalized HIV epidemics. Sequence data generated under PANGEA-­‐HIV will be publicly available, and the consortium dataset, including matched demographic data, will be available for collaborative research from external groups. PHYLODYNAMICS METHOD COMPARISON EXERCISE
Following the initial satellite meeting in Tucson in May 2014, PANGEA-­‐HIV has been running a phylogenetic method comparison exercise, with the participation of groups who are active in this area from all round the world. In this exercise, 2 agent based models of HIV epidemics were generated, representing two different epidemic scenarios. Transmission trees were generated from the models, which were used as the basis for simulations of HIV sequence evolution. From these sequence datasets samples were taken to represent viral sequences obtained from infected populations in intervention trials. Many different methods, some quite novel, were applied to the data analysis and the results discussed. A preliminary meeting was held in London in December 2014 where 8 groups presented analyses of the initial datasets. Since then new datasets have been released and the results of the final analyses will be presented and discussed at this Satellite Workshop. All attending the HIV Dynamics Workshop are invited to attend, free of charge.
Consortium Executive Group: Deenan Pillay, UCL/Africa Centre (PI); Christophe Fraser (Imperial College); Paul Kellam (Wellcome Trust Sanger Institute); Andrew Leigh Brown (University of Edinburgh); Tulio d’Oliveira (Africa Centre)