TECHNICAL DATA SHEET
Prostate™
Prostate™ formula contains vital herbs and nutrients that support proper prostate
and urinary function, while modulating optimal prostaglandin and prolactin metabolism in the prostate. We include two forms of Saw palmetto. The first is standardized
to contain 85% total fatty acids and 0.15% phytosterols (640mg), from Euromed®,
whose parent company is the world famous Madaus Gmbh of Germany, a leading
European manufacturer of the highest quality botanical medicines available. The
second is a traditional non-standardized, organic berry extract that contains all the
active constituents (375mg). African Pygeum is also from Euromed®, a 200:1
standardized extract containing 25% total sterols. We also include zinc, Stinging
nettle root, lycopene, Swedish flower pollen, pumpkin seed extract, pipsissewa and
catechins from Green tea extract. All our botanicals meet the highest standards in
the industry being tested both qualitatively with thin layer chromatography (TLC) and
high performance liquid chromatography (HPLC). Prostate™ is specifically
formulated to improve prostate function and health.
INGREDIENTS:
S u p p l e m e n t
Serving size: 3 capsules
Servings per container: 30
F a c t s
%DV
Amount per serving
Vitamin B6 (as Pyridoxine HCl)
75 mg
100%
Magnesium (Glycinate)
75 mg
20%
Zinc (as Methionine)
24 mg
20%
Saw palmetto extract (85% total fatty acids and 0.15% phytosterols) (berries)
640 mg
20%
Saw palmetto berries
375 mg
25%
Green tea extract (50% catechins)
300 mg
*
Nettle root dry extract (5% total A.A. & 0.8% b-sitosterol)
225 mg
*
African pygeum extract (bark) (200:1) (2.5% sterols)
150 mg
*
Pipsissewa (leaf)
75 mg
*
Pumpkin seed dry extract (4:1) (seed)
75 mg
*
Swedish flower (as Cernitin®) (pollen)
30 mg
*
5 mg
*
Lycopene
Percent Daily Values are based on a 2,000 calorie diet.
* Daily Value not established.
Other Ingredients: Vegetarian capsules
Saw Palmetto
Saw palmetto has been utilized for decades to support
healthy prostate and urinary function. The ripe fruit of the
Saw palmetto contains volatile oils and fatty oils, which are
active in treating benign prostatic hyperplasia (BPH). Many
saw palmetto products are standardized based on the fatty
acid content. The most effective Saw palmetto products
seem to be whole berries or berry extracts prepared with
lipophilic nonpolar solvents. Saw palmetto shrinks the inner
prostatic epithelium (1). In a recently published JAMA
meta-analysis involving 18 randomized controlled trials and
almost 3,000 men, results suggest that Saw palmetto
provides important urologic support by promoting healthy
urinary function (2). Its primary mode of action involves
maintaining healthy testosterone metabolism.
Pygeum Africanum
Pygeum Africanum bark extracts have antiproliferative
effects on prostatic fibroblasts and epithelial cells. Pygeum
appears to inhibit growth factors such as basic fibroblast
growth factor (bFGF), epidermal growth factor (EGF), and
insulin-like growth factor (IGF), which inhibit prostate growth
and cellular hyperplasia (3). Preclinical research suggests
that pygeum improves bladder contractility. It seems to affect
adrenal androgens and to restore the secretory activity of
prostate epithelium. It also decreases production of leukotrienes and other 5-lipoxygenase metabolites, which suggests
anti-inflammatory activity (4).
Swedish Flower Pollen (Cernitin®)
Swedish flower pollen has positive prostate cell
metabolism qualities and influences healthier and stronger
urine flow. In a double-blind clinical study, Cernitin®
demonstrated support for urination variables and prostate
health (5).
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Swedish Flower Pollen (Cernitin®) continued
Cernitin® provides a healthy spectrum of nutrients including
vitamins, minerals, carotenoids, flavonoids, nucleic acids, and
enzymes.
Lycopene
Lycopene is a carotenoid, but contains no Vitamin A activity. It
is the pigment that gives some fruits and vegetables, such as
tomatoes, their color. Lycopene seems to have some direct
effects within the prostate, specifically up-regulating tumor
suppressor genes (6). Clinical studies have linked lycopenes
presence with a lower risk of prostate cancer. Lycopene tends
to be concentrated more in healthier prostate glands and its
adequate presence reduces the risk of prostate cancer.
Pumpkin Seed Extract
Pumpkin seed extract is rich in carotenoids, including lutein,
carotene, and beta-carotene. The enzyme acyl-coenzyme A
oxidase (ACOX) is present in the pumpkin seed. The ACOX
enzyme catalyzes fatty acid oxidation, specifically the oxidation
of fatty acid CoA esters with 4 to 10 carbon atoms (7).
Research suggests pumpkin seed extract improves bladder
and urethral function, which appears to alleviate BPH
symptoms (8).
Pipsissewa
Pipsissewa includes the above ground parts used as the
applicable parts. The component chimaphilin has a mild
sensitizing effect and contains the glycoside hydroquinone as
the active constituent in pipsissewa. Chimaphilin appears to
have urinary antiseptic, bacteriostatic, and astringent activity
(9). Pipsissewa is used in atonic, chronic and infectious
conditions such as prostatitis and benign prostatic hypertrophy
(BPH). Pipsissewa promotes bladder integrity and strengthens
urine flow.
Stinging Nettle Root
Stinging nettle root contains polysaccharides that possess
immunomodulating and mild anti-inflammatory effects (10). The
root seems to have an antiproliferative effect on prostatic
epithelial and stromal cells (11); and also may lessen the effects
of androgenic hormones by competitively blocking access to
human sex hormone binding globulin (SHBG) (12). In
numerous clinical studies in Germany, Stinging nettle root was
shown to maintain proper SHGB activity.
Green Tea
Green tea is from the leaf bud, leaf and stem. Green tea is
different from black and oolong teas because it is not
fermented. Polyphenols such as flavanols, flavandiols,
flavonoids, and phenolic acids are abundant in Green tea.
Catechins in Green tea might appear to have anti-inflammatory
activity. Catechins derived from Green tea are a laboratory
standard for COX-1 inhibition (13). Catechins from Green tea
inhibit the production of leukotriene-B4 and the activity of
5-lipoxygenase (14).
Zinc
Zinc concentration in the prostate is the highest amount of
any organ in the male body. Zinc plays a critical role in the
metabolism of androgens, which play a vital role in prostate
health. A zinc deficiency is characterized by low sperm
counts and delayed onset of puberty among other known
deficiencies (15). Zinc inhibits the binding of androgens in the
prostate and also inhibits 5-alpha-reductase. Zinc inhibits
prolactin secretion and reduces the binding of prolactin in the
prostate.
Magnesium
Magnesium is involved with more than 300 enzyme systems.
Magnesium is involved in vascular contraction,
neuromuscular function, and cell membrane stability and
fluidity.
Vitamin B6 (Pyridoxine)
Vitamin B6 is required for amino acid
metabolism. It is also involved in carbohydrate and lipid
metabolism. Pyridoxine (B6) is significant in hormone
synthesis, nerve impulse transmission, and hemoglobin
formation.
Patients: Consult with your healthcare professional
for the proper dosage and use of this formula.
For more information about this and other Condition
Specific Formulas® please visit our website at:
www.mpn8.com
Portland, OR 97225
REFERENCES:
1. J Urol 2000;163:1451-6
2. JAMA 1998 (18):1604-9
3. J Ural 1997;157:2881-7
4. Am J Med 2000;109:254-64
5. Prostate 2001;49:122-31
6. Cancer Epidermal Biomarkers Prep 2001;10:861-8
7. Plant Physiol 2000;123:327-34
8. Urology 1999;54:86-9
9. Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics 1996; Leung AY, Foster S.
10. Monographs on the medicinal uses of plant drugs 1997; Exeter, UK: European Scientific Co-op
11. Plant Med 2000;66:44-7
12. Plant Med 1997;63:529-32
13. J Surg Res 2004;119:138-42
14. Ann Nutr Metab 2004;48:151-5
15. J Nutr 2001;4:1135-41