Notes Chapter 1: A New Approach to Bladder and Pelvic Pain 1. A. S. Herati, B. Shorter, J. Tai, L. Martin, and R. M. Moldwin, “Differences in Food Sensitivities Between Female Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS) and Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) Patients,” American Urological Association 2009 Research News 60 (April 2009, Chicago). 2. R. Peeker, L. Atanasiu, and Y. Logadottir, “Intercurrent Autoimmune Conditions in Classic and Non-ulcer Interstitial Cystitis,” Scandinavian Journal of Urology and Nephrology 37, no. 1 (2003): 60–63. 3. M. Alagiri, S. Chottiner, V. Ratner, D. Slade, and P. M. Hanno, “Interstitial Cystitis: Unexplained Associations with Other Chronic Disease and Pain Syndromes,” Urology 49, no. 5A (1997): 52–57. 4. M. Rodríguez, N. Afari, and D. Buchwald, “Evidence for Overlap Between Urological and Nonurological Unexplained Clinical Conditions,” The Journal of Urology 182, no. 5 (2009): 2123–131. 5. J. C. Nickel, D. A. Tripp, M. A. Pontari, R. M. Moldwin, R. Mayer, L. K. Carr, R. Doggweiler, C. C. Yang, D. Whitcomb, N. Mishra, and J. Nordling, “Phenotypical Associations Between Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS) and Irritable Bowel Syndrome (IBS), Fibromyalgia (FM), Chronic Fatigue Syndrome (CFS): A Case Control Study,” The Journal of Urology 181 (2009): 19–20. 6. Alagiri, Chottiner, Ratner, Slade, and Hanno, “Interstitial Cystitis: Unexplained Associations,” 52–57. 7. M. C. Erasmus, “Interstitial Cystitis and Systemic Autoimmune Diseases,” Nature— Clinical Practice Urology 4, no. 9 (September 2007): 484–91; Peeker, Atanasiu, and Logadottir, “Intercurrent Autoimmune Conditions,” 60–63. 8. A. Smith, “Moving into the Future: New Dimensions and Strategies for Women’s Health Research,” Arthur Smith Institute of Urology, Smith Blog, 28 May 2009, http://www.smithinstituteforurology.com/blog/?tag=interstitial-cystitis (accessed 10 Oct 2009). Chapter 2: Understanding the Basics 1. L. J. Henderson, “Diagnosis, Treatment, and Lifestyle Changes of Interstitial Cystitis: Statistical Data Included,” AORN Journal, Official Journal—Association of periOperative Registered Nurses, FindArticles.com http://findarticles.com/p/articles/mi_m0FSL/is_3_71/ai_64423988/ (accessed 14 March 2010). 2. Michael Moore, Herbs for the Urinary Tract (New York: McGraw-Hill, 1999), 23. 3. Christiane Northrup, The Wisdom of Menopause: Creating Physical and Emotional Health During the Change rev. ed. (New York: Bantam, 2006), 213. 4. R. Chalker and K. Whitmore, Overcoming Bladder Disorders (New York: Harper Collins Press, 1990). 5. B. Foxman, “Epidemiology of Urinary Tract Infections: Incidence, Morbidity, and Economic Costs,” American Journal of Medicine 113, Suppl 1A (2002): 5S–13S. 6. B. J. Barnett and D. S. Stevens, “Urinary Tract Infection: An Overview,” The American Journal of the Medical Sciences 314, no. 4 (October 1997): 245–49. 7. D. J. G. Thirion and D. Williamson, “Urinary Tract Infections,” Canadian Pharmacists Association Professional Advancement Learning Series (Ottawa, ON: 2004). 8. Ibid. 9. Ibid. 10. S. Ahuga, B. Kaack, and J. Roberts, “Loss of Fimbrial Adhesion with the Addition of Vaccinium macrocarpon to the Growth Medium of P-fimbriated Escheriachia coli,” The Journal of Urology 159, no. 2 (1998): 559–62; A. B. Howell, N. Vorsa, A. Der Marderosian, and L. Y. Foo, “Inhibition of the Adherence of P-fimbriated Escherichia Coli to Uroepithelial-Cell Surfaces by Proanthocyanidin Extracts from Cranberries,” The New England Journal of Medicine 339, no. 15 (1998): 1408. 11. Thirion and Williamson, “Urinary Tract Infections.” 12. Ibid. 13. C. Northrup, The Wisdom of Menopause: Creating Physical and Emotional Health During the Change, rev. ed. (New York: Bantam, 2006), 267. 14. Ibid. 15. National Institutes of Health, “Cystocele (Fallen Bladder),” NIH Publication no. 07–4557 (August 2007), http://kidney.niddk.nih.gov/kudiseases/pubs/cystocele/index.htm (accessed 13 Oct 2009). 16. National Institutes of Health, NIH Publication no. 10–3220 (December 2009) http://kidney.niddk.nih.gov/kudiseases/pubs/interstitialcystitis/index.htm (accessed 20 March 2010). 17. C. Theoharides, X. Pang, R. Letorneau, and G. R. Sant, “Interstitial Cystitis: A Neuroimmunoendocrine Disorder,” in Annals of the New York Academy of Sciences, 840 (February 2006), http://www3.interscience.wiley.com/journal/119114898/abstract. 18. S. H. Berry, M. A. Stoto, M. Elliot, M. Suttorp, L. Bogart, P. W. Eggers, L. M. Nyberg, Jr., and J. Q. Clemens, “Prevalence of Interstitial Cystitis/Painful Bladder Syndrome in the United States,” American Urological Association Meeting proceedings, #56, Chicago, IL, April 2009, http://www.painful-bladder.org/pdf/2009_AUA_Chicago.pdf (accessed 30 July 2010). 19. M. C. Stoppler and J. W. Marks, “Interstitial Cystitis,” http://www.medicinenet.com/interstitial_cystitis/article.htm (accessed 10 January 2009). 20. Berry, Stoto, Elliot, Suttorp, Bogart, Eggers, Nyberg, and Clemens, “Prevalence of Interstitial Cystitis/Painful Bladder Syndrome in the United States.” 21. J. D. Kaye and R. M. Moldwin, “Interstitial Cystitis in Men: Diagnosis, Treatment, and Similarities to Chronic Prostatitis,” in Chronic Prostatitis/Chronic Pelvic Pain Syndrome, ed. D. Shoskes (New York: Humana Press, 2008), 189–208. 22. B. Gardella, D. Porru, F. Ferdeghini, E. Martinotti Gabellotti, R. Nappi, A. Rovereto, and A. Spinillo, “Insight into Urogynecologic Features of Women with Interstitial Cystitis/Painful Bladder Syndrome,” European Urology 54 (November 2008) 5: 1145–53. 23. G. R. Sant, “Interstitial Cystitis and Pelvic Pain Syndromes,” Masters in Urology Meeting, Elbow Beach Resort, Bermuda, 31 July 2008–2 Aug 2008. http://www.medicalnewstoday.com/articles/117492.php (accessed 13 March 2010); R. Moldwin, The Interstitial Cystitis Survival Guide: Your Guide to the Latest Treatment Options and Coping Strategies (Oakland, CA: New Harbinger Publications, 2000), 6. 24. J. W. Warren, S. K. Keay, D. Meyers, and J. Xu, “Concordance of Interstitial Cystitis in Monozygotic and Dizygotic Twin Pairs,” Urology 57, no. 6 (2001): suppl. 1: 22–25; J. W. Warren, T. L. Jackson, P. Langenberg, D. Meyers, and J. Xu, “Prevalence of Interstitial Cystitis in First-Degree Relatives of Patients with Interstitial Cystitis,” Urology 63, no. 1 (January 2004): 17–21. 25. W. W. Eaton, N. R. Rose, A. Kalaydijian, M. G. Pedersen, and P. B. Mortensen, “Epidemiology of Autoimmune Diseases in Denmark,” Journal of Autoimmunity 29, no. 1 (August 2007): 1–9. 26. M. M. Weissman, R. Gross, A. Fyer, G. A. Heiman, M. J. Gameroff, S. E. Hodge, D. Kaufman, S. A. Kaplan, and P. J. Wickramaratne, “Interstitial Cystitis and Panic Disorder,” Archives of General Psychiatry 61, no. 3 (March 2004): 273–79. 27. M. C. Erasmus, “Interstitial Cystitis and Systemic Autoimmune Diseases,” Nature— Clinical Practice Urology 4, no. 9 (September 2007): 484–91. 28. International Painful Bladder Foundation, “Sjögren’s Syndrome and IC/PBS Association,” IXth International Symposium on Sjögren’s Syndrome (Washington, DC: 27–29 April 2006) http://www.painful-bladder.org/2006_ISSS_Washington.html (accessed 13 March 2010). 29. J. Van de Merwe, R. Kamerling, E. Arendsen, D. Mulder, and H. Houijkass, “Sjögren’s Syndrome in Patients with IC,” Journal of Rheumatology 20, no. 6 (June 1993): 962–66. 30. M. Haarala, A. Alanen, M. Hietarinta, and P. Kiiholma, “Lower Urinary Tract Symptoms in Patients with Sjögren’s Syndrome and Systemic Lupus Erythematosus,” International Urogynecological Journal of Pelvic Floor Dysfunction 11, no. 2 (2000): 84–86. 31. P. Green and R. Jones, Celiac Disease—A Hidden Epidemic (New York: Collins Press, 2006), 152.; P. H. R. Green, A. Alaedini, H. W. Sander, T. H. Brannagan, N. Latov, and R. L. Chin, “Mechanisms Underlying Celiac Disease and Its Neurological Manifestations,” Cellular and Molecular Life Sciences. 62, no. 7 (2005): 791–99; J. Wright, Foreword in Dangerous Grains—Why Gluten Cereal Grains May Be Hazardous to Your Health, by J. Braly and R. Hoggan (New York: Avery Press, 2002), xi–xiv. 32. T. Yamada, M. Funahashi, and T. Muravama, “Clinical Evaluation of 30 Patients with Interstitial Cystitis Complicated by Fibromyalgia,” Nippon Hinyokika Gakkai Zasshi 96, no. 5 (July 2005): 554–59. 33. D. J. Clau, M. Schmidt, D. Radulovic, A. Singer, P. Katz, and J. Bresette, “The Relationship Between Fibromyalgia and Interstitial Cystitis,” Journal of Psychiatric Research 31, no. 1 (January–February 1997): 125–31. 34. R. Peeker, L. Atanasiu, and Y. Logadottir, “Intercurrent Autoimmune Conditions in Classic and Non-ulcer Interstitial Cystitis,” Scandinavian Journal of Urology and Nephrology 37, no. 1 (2003): 60–63. 35. M. C. Erasmus, “Interstitial Cystitis and Systemic Autoimmune Diseases,” Nature— Clinical Practice Urology 4, no. 9 (September 2007): 484–91. 36. R. Mandar, E. Raukas, T. Silver, P. Korrovits, and M. Punab, “Mycoplasmas in Semen of Chronic Prostatitis Patients,” Scandinavian Journal of Urology and Nephrology 39, no. 6 (December 2005): 479–82. 37. D. D. Riley and J. N. Krieger, “Chromosomal Short Tandem Repeat Polymorphisms Near the Phosphoglycerate Kinase Gene in Men with Chronic Prostatitis,” Biochimica et Biophysica Acta (BBA)—Molecular Basis of Disease 1586, no. 1 (January 2002): 99–107. 38. D. Wise and R. Anderson, A Headache in the Pelvis—A New Understanding and Treatment for Prostatitis and Chronic Pelvic Pain Syndrome (Occidental, CA: National Center for Pelvic Pain, 2003), 35–36. 39. Urologic Chronic Pelvic Pain Syndrome Society, “Prostatitis, Chronic Prostatitis, CP/CPPS, UCPPS: Male Urologic Chronic Pelvic Pain Syndrome,” 23 July 2008. http://knol.google.com/k/prostatitis-chronic-prostatitis-cp-cpps-ucpps# (accessed 14 March 2010). 40. J. C. Lee, C. H. Muller, I. Rothman, K. Agnew, D. Eschenbach, M. A. Ciol, J. A. Turner, and R. E. Berger, “Prostate Biopsy Culture Findings of Men with Chronic Pelvic Pain Syndrome Do Not Differ from Those of Healthy Controls,” The Journal of Urology 169, no. 2 (2003): 584– 88. 41. Ibid. 42. R. M. Moldwin, “Similarities Between Interstitial Cystitis and Male Chronic Pelvic Pain Syndrome,” Concurrent Urology Reports (2002): 313–18.; R. E. Berger, J. E. Miller, I. Rothman, J. N. Krieger, and C. H. Muller, “Bladder Petechiae after Cystoscopy and Hydrodistention in Men with Prostate Pain,” The Journal of Urology 159 (1998): 83–85. 43. G. R. Sant, “Interstitial Cystitis and Pelvic Pain Syndromes”; D. E. Novicki, T. R. Larson, and S. K. Swanson, “Interstitial Cystitis in Men,” Urology 52 (October 1998): 621–24. 44. D. A. Shoskes, Chronic Prostatitis/Chronic Pelvic Pain Syndrome (New York: Humana Press, 2008), 270. Chapter 3: Traditional Treatments 1. J. V. Jepsen, M. Sall, P. R. Rhodes, D. Schmidt, E. Messing, and R. C. Bruskewitz, “Long-Term Experience with Pentosanpolysulfate in Interstitial Cystitis,” Urology 51, no. 3 (March 1998): 381–87. 2. Ortho-McNeil Pharmaceutical, Inc., “Medication Guide: Elmiron (pentosan polysulfate sodium),” revised March 2010, http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=8130 (accessed 15 March 2010). 3. Ortho Women’s Health and Urology for Healthcare Professionals, “Elmiron (pentosan polysulfate sodium) Efficacy Data, Side Effects, FAQ’s: Important Safety Information,” modified 22 December 2009, http://www.myortho360.com/myortho360/elmiron/efficacy_data.html (accessed 15 March 2010). 4. National Institutes of Health, NIH Publication no. 10–3220 (December 2009) http://kidney.niddk.nih.gov/kudiseases/pubs/interstitialcystitis/index.htm (accessed 13 March 2010). 5. H. J. McQuay, M. Tramèr, B. A. Nye, D. Carroll, P. J. Wiffen, and R. A. Moore, “A Systematic Review of Antidepressants in Neuropathic Pain,” Pain 68 (1996): 217–27. 6. M. Kerr, “Neurontin: A Treatment for Chronic Pain,” in IC Lifestyles and Exercise—A Monthly Column on Lifestyle, Fitness and Relationships by Gaye and Andrew Sandler, http://www.ic-network.com/iclifestyles/may03.html (accessed 5 March 2010). 7. D. Carr, in: Kerr, M., “Neurontin: A Treatment for Chronic Pain,” in IC Lifestyles and Exercise—A Monthly Column on Lifestyle, Fitness and Relationships by Gaye and Andrew Sandler, http://www.ic-network.com/iclifestyles/may03.html (accessed 5 March 2010). 8. Kerr, “Neurontin: A Treatment for Chronic Pain.” 9. L. J. Crofford, M. C. Rowbotham, P. J. Mease, I. J. Russell, R. H. Dworkin, A. E. Corbin, J. P. Young, L. K. LaMoreaux, S. A. Martin, and U. Sharmaet, “Pregabalin for the Treatment of Fibromyalgia Syndrome: Results of a Randomized, Double-Blind, Placebo-Controlled Trial,” Arthritis and Rheumatism 52 (2005): 1264–73. 10. Pfizer for Professionals, “Prescribing Information Lyrica (pregalbin) Capsules— Warnings and Precautions,” https://www.pfizerpro.com/sites/PPro/pages/product_info/lyrica_pi_warnings_precautions.aspx (accessed 30 June 2010). 11. C. L. Parsons, “Expert Opinion on Pharmacotherapy,” Informa Healthcare. http://informahealthcare.com/doi/abs/10.1517/14656566.7.4.411?cookieSet=1&journalCode=eo p (accessed 14 March 2010). 12. T. M. Sofinowski, P. J. Hauser, D. D. Buethe, J. A. Califano, D. J. Clulkin, and R. E. Hurst, “Intravesically Applied Chondroitin Sulfate Restores Urothelial Barrier Function in Aciddamaged Bladder,” American Urological Association Meeting proceedings, Chicago, IL, 2009, http://www.ichelp.org/Page.aspx?pid=748 (accessed 30 June 2010). 13. A. Morales, L. Emerson, and J. C. Nickel, “Intravesical Hyaluronic Acid in the Treatment of Refractory Interstitial Cystitis,” The Journal of Urology 156, no. 1 (July 1996): 45–48. 14. J. Kaufman, P. Tyagi, and M. B. Chancellor, “Intravesical Liposomal (LP08) Instillation Protects Bladder Urothelium from Chemical Irritation,” American Urological Association (meeting 2009). 15. The Interstitial Cystitis Network, “About Bladder Instillations,” (2006) http://www.icnetwork.com/handbook/instill.html (accessed 13 October 2009). 16. National Institutes of Health, NIH Publication no. 10–3220, December 2009 http://kidney.niddk.nih.gov/kudiseases/pubs/interstitialcystitis/index.htm 17. Ibid; L. J. Henderson, “Diagnosis, Treatment, and Lifestyle Changes of Interstitial Cystitis—Statistical Data Included,” AORN Journal, Official Journal—Association of periOperative Registered Nurses (March, 2000) BNET, http://findarticles.com/p/articles/mi_m0FSL/is_3_71/ai_64423988/pg_3 (accessed 14 October 2009). 18. K. Doi, Y. Saito, T. Nikai, N. Morimoto, T. Nakatani, and S. Sakura, “Lumbar Sympathetic Block for Pain Relief in Two Patients with Interstitial Cystitis,” Regional Anesthesia and Pain Medicine 26, no. 3 (May 2001): 271–73. Chapter 4: Learning to Manage Symptoms 1. Anxiety Disorders Association of America (ADAA), “Stress and Anxiety Interfere with Sleep,” (2010), http://www.adaa.org/understanding-anxiety/related-illnesses/other-relatedconditions/stress/stress-and-anxiety-interfere (accessed 16 March 2010). 2. M. H. Sacks, “Exercise for Stress Control,” in: Mind/Body Medicine: How to Use Your Mind for Better Health by D. Goleman (Yonkers, NY: Consumer Reports Books, 1993). 3. K. F. Koltyn, A.W. Garvin, R. L. Gardiner, and T. F. Nelson, “Perception of Pain Following Aerobic Exercise,” Medicine and Science in Sports and Exercise 28, no. 11 (November 1996): 1418–21. 4. M. C. Ross, A. S. Bohannon, D. C. Davis, and L. Gurchick, “The Effects of a Short-Term Exercise Program on Movement, Pain, and Mood in the Elderly,” Journal of Holistic Nursing 17, no. 2 (1999): 139–47. 5. H. B. Nielsen, “Lymphocyte Responses to Maximal Exercise: A Physiological Perspective,” Sports Medicine 33 (2003): 853–67. 6. D. C. Nieman, S. L. Nehlsen-Cannarella, P. A. Markoff, A. J. Balk-Lamberton, H. Yang, D. B. Chritton, J. W. Lee, and K. Arabatzis, “The Effects of Moderate Exercise Training on Natural-killer-cells and Acute Upper Respiratory-tract Infections,” International Journal of Sports Medicine 11 (1990): 467–73. 7. K. Kursat, O. Saygin, R. Ozmeridivenli, E. Zorba, A. Godekmerdan, and V. Bulut, “The Effects of Exercise on the Immune System and Stress Hormones in Sportswomen,” Neuroendocrinology Letters 26, no. 4 (August 2005). 8. H. Bruunsgaard, “Physical Activity and Modulation of Systemic Low-level Inflammation,” Journal of Leukocyte Biology 78 (2005): 819–835. 9. L. H. Colbert, M. Visser, E. M. Simonsick, R. P. Tracy, A. B. Newman, S. B. Kritchevsky, M. Pahor, D. R. Taaffe, J. Brach, S. Rubin, and T. B. Harris, “Physical Activity, Exercise, and Inflammatory Markers in Older Adults: Findings from The Health, Aging, and Body Composition Study,” Journal of the American Geriatrics Society 52, no. 7 (2004): 1098– 104. 10. Natural Therapy Pages, “Exercise and Endorphins,” http://www.naturaltherapypages.com.au/article/Exercise_Endorphins (accessed 10 January 2009). 11. M. Guszkowski, “Effects of Exercise on Anxiety, Depression, and Mood,” Psychiatria Polska 38, no. 4 (July–August 2004): 611–20. 12. B. Shorter, M. Lesser, R. Moldwin, and L. Kushner, “Effect of Comestibles on Symptoms of Interstitial Cystitis,” The Journal of Urology 178, no. 1 (2007): 145–52. 13. Mayoclinic, “Urinary Incontinence,” (June 2009) http://www.mayoclinic.com/health/urinary-incontinence/DS00404/DSECTION (accessed 29 Sept 2009). 14. P. Osusu-Agyei, S. G. Parker, and M. Hill, “Inflammatory Markers in Urine in Interstitial Cystitis, Bacterial Cystitis and Detrusor Instability,” (May 1999) http://findarticles.com/p/articles/mi_m2459/is_3_28/ai_n27550280 (accessed 20 March 2010) 15. A. K. Willis, Solving the Interstitial Cystitis Puzzle: A Guide to Natural Healing, rev. ed. (Los Angeles, CA: Holistic Life Enterprises, 2003). 16. U. Tomohiro, N. Masayuki, O. Motohiro, T. Hideki, and Y. Naoki, “Urine Alkalinization Improves the Problems of Pain and Sleep in Patients with Interstitial Cystitis,” American Urological Association Meeting proceedings, Chicago, IL, 2009, http://www.ichelp.org/Page.aspx?pid=748 (accessed 30 June 2010). 17. W. A. McGarey, The Oil That Heals: A Physician’s Successes with Castor Oil Treatments (Virginia Beach, VA: ARE Press, 1993). 18. Capsaicin Study Group, “Treatment of Painful Diabetic Neuropathy with Topical Capsaicin. A Multicenter, Double-blind, Vehicle-controlled Study,” Archives of Internal Medicine 151 (1991): 2225. 19. J. J. Gagnier, M. W. van Tulder, B. Berman, and C. Bombadier, “Herbal Medicine for Low Back Pain: A Cochrane Review,” Spine 32 (2007): 82–92; L. Mason, R. A. Moore, S. Derry, J. E. Edwards, and H. J. McQuay, “Systematic Review of Topical Capsaicin for the Treatment of Chronic Pain,” BMJ 328, no. 7446 (24 April 2004): 998; C. P. Watson, “Topical Capsaicin as an Adjuvant Analgesic,” Journal of Pain and Symptom Management 9 (1994): 425– 33. 20. D. Guttierrez, “Chronic Pain and Fatigue Associated with Vitamin D Deficiency,” Natural News.com (6 January 2009), http://www.naturalnews.com/025237.html (accessed 11 April 2009). 21. H. Glerup, K. Mikkelsen, L. Poulsen, E. Haas, S. Overbeck, J. Thomsen, P. Charles, and E. F. Eriksen, “Commonly Recommended Daily Intake of Vitamin D Isn’t Sufficient If Sunlight Exposure Is Limited,” Journal of Internal Medicine 247, no. 2(2000): 260–68. 22. K. L. Munger, L. I. Levin, B. W. Hollis, N. W. Howard, and A. Ascherio, “Serum 25Hydroxyvitamin D Levels and Risk of Multiple Sclerosis,” Journal of the American Medical Association 296 (2006): 2832–38. 23. M. F. Holick, “Vitamin D Deficiency,” The New England Journal of Medicine 357, no. 3 (July 2007): 266–81. 24. F. Benigni, E. Baroni, M. Zecevic, P. Zvara, T. Streng, P. Hedlund, E. Colli, D. D’Ambrosio, and K. Andersson, “Oral Treatment with A Vitamin D3 Analogue (BXL628) Has Anti-inflammatory Effects in Rodent Model of Interstitial Cystitis,” British Journal of Urology International 97, no. 3 (2006): 617–24. 25. J. Oelke, “Are You Deficient in GABA? You May Be if You Have Chronic Pain,” Fibromyalgia Newsletter, January 2005. http://www.naturalchoicesforfibromyalgia.com/site/678806/page/472087 (accessed 20 March 2010). 26. E. Braverman, “When the Brain Goes, So Goes Your Health,” The Huffington Post (12 March 2010), http://www.huffingtonpost.com/dr-eric-braverman/when-the-brain-goes-sogo_b_175323.html (accessed 20 March 2010). 27. E. Braverman, The Edge Effect: Achieve Total Health and Longevity With The Balanced Brain Advantage (Salt Lake City, UT: Sterling Press, 2005). 28. R. Moldwin, The Interstitial Cystitis Survival Guide: Your Guide to the Latest Treatment Options and Coping Strategies (Oakland, CA: New Harbinger Publications, 2000), 109. 29. Mayoclinic, “Arginine/L-Arginine” (1 February 2010), http://www.mayoclinic.com/health/l-arginine/NS_patient-arginine/DSECTION=evidence (accessed 16 March 2010). 30. Medline Plus, U.S. National Library of Medicine and NIH. “Arginine (LArginine),”http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-arginine.html (accessed 16 March 2010). 31. Web MD, “Glutamine,” http://www.webmd.com/vitamins-supplements/ingredientmono878GLUTAMINE.aspx?activeIngredientId=878&activeIngredientName=GLUTAMINE&source=2 (accessed 30 June 2010). 32. M. Marchese, “Endometriosis,” Townsend Letter (April 2009), http://www.townsendletter.com/April2009/endometriosis0409.htm (accessed 16 March 2010). 33. D. Morgan, “Study Isolates Virus in Chronic Fatigue Sufferers,” Reuters (8 Oct 2009), http://www.reuters.com/article/latestCrisis/idUSN08539703 (accessed 14 March 2010). 34. M. Skelly and H. Walker, Alternative Treatments for Fibromyalgia and Chronic Fatigue Syndrome, rev. 2nd ed. (Alameda, CA: Hunter House Publishers, 2007). Chapter 5: What’s Bugging Your Bladder? 1. A. S. Herati, B. Shorter, J. Tai, L. Martin, and R. M. Moldwin, “Differences in Food Sensitivities Between Female Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS) and Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) Patients,” AUA 2009 Research News, http://www.painful-bladder.org/pdf/2009_AUA_Chicago.pdf (accessed 17 March 2010); R. Peeker, L. Atanasiu, and Y. Logadottir, “Intercurrent Autoimmune Conditions in Classic and Non-ulcer Interstitial Cystitis,” Scandinavian Journal of Urology and Nephrology 37, no. 1 (2003): 60–63; M. Alagiri, S. Chottiner, V. Ratner, D. Slade, and P. M. Hanno, “Interstitial Cystitis: Unexplained Associations with Other Chronic Disease and Pain Syndromes,” Urology 49, Suppl. 5A (2006): 52–7; J. Lee, R. Doggweiler-Wiygul, S. Kim, B. D. Hill, and T. J. Yoo, “Is Interstitial Cystitis an Allergic Disorder? A Case of Interstitial Cystitis Treated Successfully with Anti-IgE,” International Journal of Urology 13, no. 5 (May 2006): 631–34. 2. Lee, Doggweiler-Wiygul, Kim, Hill, and Yoo, “Is Interstitial Cystitis an Allergic Disorder?” 3. T. C. Theoharides and D. E. Cochrane, “Critical Role of Mast Cells in Inflammatory Diseases and the Effect of Acute Stress,” Journal of Neuroimmunology 146 (2004): 1–12. 4. D. J. Klumpp and C. N. Rudick, “Summation Model of Pelvic Pain in Interstitial Cystitis,” Nature—Clinical Practice Urology 5 (2008): 494–500. 5. Ibid. 6. D. Sandberg, J. Brostoff, and S. Challacombe, “Food Sensitivity: The Kidney and Bladder,” in Food Allergy and Intolerance (London: Bailliere Tindall, 1987), 755–76. 7. A. Sanchez-Palacios, A. Quintero de Juana, J. Martinez-Sagarra, and R. Aparicio-Duque, “Eosinophilic Food-Induced Cystitis,” Allergologia et Immunolopathologia 12 (1984): 463–69. 8. R. Peeker, L. Atanasiu, and Y. Logadottir, “Intercurrent Autoimmune Conditions in Classic and Non-ulcer Interstitial Cystitis,” Scandinavian Journal of Urology and Nephrology 37, no. 1 (2003): 60–63. 9. S. G. Larsson, L. Bergkvist, and A. Wolk, “Consumption of Sugar and Sugar-sweetened Foods and the Risk of Pancreatic Cancer in a Prospective Study,” American Journal of Clinical Nutrition 84, no. 5 (November 2006): 1171–76. 10. E. Vliet, Screaming to Be Heard: The Hormonal Connection Women Suspect and Doctors Still Ignore, rev. exp. ed. (New York: M. Evans and Company, 2001), 311–14. 11. T. O’Bryan, “Unlocking the Secrets of Gluten Sensitivity: Implications for Neurological, Musculoskeletal, and Immune Health,” Metagenics, NANP Seminar Syllabus (2008). 12. P. Green and R. Jones, Celiac Disease: A Hidden Epidemic (New York: Collins Press, 2006), 41. 13. M. Hadjivassiliou, A. Grunewald, and G. A. Davies-Jones, “Gluten Sensitivity as a Neurological Illness,” Journal of Neurology, Neurosurgery, and Psychiatry 72 (2002): 560–63; O’Bryan, “Unlocking the Secrets of Gluten Sensitivity.” 14. Green and Jones, Celiac Disease. 15. C. J. Libonati, Recognizing Celiac Disease: Signs, Symptoms, Associated Disorders and Complications (Fort Washington, PA: Gluten Free Works, 2007), ix, 15. 16. Alpha Online Children, “Helping Children,” http://www.nutramed.com/children/children_bladder_kidneys.htm (accessed 13 Oct 2009). 17. F. Emmite, personal communications with the author, 12 December 2009 and 5/6 July 2010. 18. D. Sanders, “There Is a Relationship Between Celiac Disease and Patients with Symptoms of Irritable Bowel Syndrome,” Gastroenterology 123, no. 4 (2002): 1408. 19. G. Michaëlsson, S. Ahs, I. Hammarström, I. P. Lundin, and E. Hagforsen, “Gluten-free Diet in Psoriasis Patients with Antibodies to Gliadin Results in Decreased Expression of Tissue Transglutaminase and Fewer Ki67+ Cells in the Dermis,” Acta Dermato-Venereologica 83, no. 6 (2003): 425–29. 20. Green and Jones, Celiac Disease. 21. O’Bryan, “Unlocking the Secrets.” 22. S. Ji, “The Dark Side of Wheat: New Perspectives on Celiac Disease and Wheat Intolerance,” Journal of Gluten Sensitivity (Winter 2008), http://www.patienthealthyself.info/Celiac_Disease_Article.html (accessed 31 March 2010). 23. P. J. D’Adamo, “Lectins, and Mitogens,” http://www.dadamo.com/science_lectins_mitogens.htm (accessed 1 March 2010). 24. C. Pierini, “Lectins: Their Damaging Role in Intestinal Health, Rheumatoid Arthritis, and Weight Loss,” Vitamin Research Products (VRP), http://www.vrp.com/articles.aspx?ProdID=2009 (accessed 14 Oct 2009). 25. S. E. Keller, J. M. Weiss, S. J. Schleifer, N. E. Miller, and M. Stein, “Suppression of Immunity by Stress: Effect of Graded Series of Stressors on Lymphocyte Stimulation in the Rat,” Science 213 (1981): 1397. 26. J. D. Minor, S. G. Tolber, and O. L. Frick, “Leukocyte Inhibition Factor in DelayedOnset Food Sensitivity,” Journal of Allergy and Clinical Immunology 6 (1980): 314. Chapter 6: The Anti-Inflammatory Diet—A Diet for Health 1. M. Pollan, In Defense of Food: An Eater’s Manifesto (New York: Penguin Press, 2008). 2. J. Black, The Anti-Inflammation Diet and Recipe Book: Protect Yourself and Your Family from Heart Disease, Arthritis, Diabetes, Allergies—and More (Alameda, CA: Hunter House Publishers, 2006); N. Appleton, Stopping Inflammation: Relieving the Cause of Degenerative Diseases (Garden City Park, NJ: Square One Publishers, 2004). Chapter 7: Understanding Chronic Pelvic Pain—The Stress Connection 1. G. Sandler, “Surviving Painful Flare Ups,” in IC Lifestyles and Exercise—A Monthly Column on Lifestyle, Fitness, and Relationships, by Gaye and Andrew Sandler (IC Network, 2005), www.ic-network.com/iclifestyles/june05.html (accessed 4 March 2010). 2. N. Rothrock, S. Lutgendorf, K. Kreder, T. Ratliff, and B. Zimmerman, “Stress and Symptoms in Patients with Interstitial Cystitis: A Life Stress Model,” Urology 57, no. 3 (2010): 422–27. 3. Sandler, “Surviving Painful Flare Ups.” 4. B. Naparstek, Invisible Heroes: Survivors of Trauma and How They Heal (New York: Bantam, 2005), 70–160. 5. S. Izquierdo-Alvarez, J. P. Bocos-Terraz, J. L. Bancalero-Flores, L. Pavón-Romero, E. Serrano-Ostariz, and C. A. de Miquel, “Is There an Association Between Fibromyalgia and Below-normal Levels of Urinary Cortisol?” BMC Research Notes (Springer) 1 (22 December 2008): 134. 6. J. Teitelbaum, Pain Free 1-2-3: A Proven Program for Eliminating Pain Now (New York: McGraw-Hill 2005), 144. 7. J. M. Teichman, “Editorial: Differences in the Clinical Presentation of Interstitial Cystitis/Painful Bladder Syndrome in Patients with or Without Sexual Abuse History,” The Journal of Urology 180, no. 5 (November 2008): 2029–33. 8. K. Peters, D. Carrico, I. Ibrahim, and A. Diokno, “Characterization of a Clinical Cohort of 87 Women with Interstitial Cystitis/Painful Bladder Syndrome,” Urology 71, no. 4 (2008): 634–40; M. Yunus, “Fibromyalgia and Overlapping Disorders: The Unifying Concept of Central Sensitivity Syndromes,” Seminars in Arthritis and Rheumatism 36, no. 6 (2007): 339–56. 9. S. Levenkron and A. Levenkron, Stolen Tomorrows: Understanding and Treating Women’s Childhood Sexual Abuse (New York: W.W. Norton, 2007). 10. A. Stein, Heal Pelvic Pain: A Proven Stretching, Strengthening, and Nutrition Program for Relieving Pain, Incontinence, IBS, and Other Symptoms Without Surgery (New York: McGraw-Hill Publishers, 2009) 31. 11. A. Goldstein, Foreword in A. Stein, Heal Pelvic Pain: A Proven Stretching, Strengthening, and Nutrition Program for Relieving Pain, Incontinence, IBS, and Other Symptoms Without Surgery (New York: McGraw-Hill Publishers, 2009), ix. 12. C. Davies, with A. Davies, The Trigger Point Therapy Workbook: Your Self-Treatment Guide for Pain Relief, 2nd ed. (Oakland, CA: New Harbinger Press, 2004), 148, 202, 208. 13. Stein, Heal Pelvic Pain, 10. 14. B. D. Thomson, “The Biology of Trigger Points: What They Are, What They Do, and When and Why They Occur,” http://www.easyvigour.net.nz/trigger_points/h_triggerpoint9.htm (accessed 18 March 2010). 15. D. Seaman, “The Key to Understanding Most Conditions and Their Nutritional Treatments: An Introduction,” http://www.nutritionalwellness.com/archives/2005/nov/11_seaman.php (accessed 11 November 2009); W. J. Meggs, “Neurogenic Inflammation and Sensitivity to Environmental Chemicals,” Environmental Health Perspectives 101, no. 3 (August 1993): 234–38; M. Zimmerman, “Pathophysiologic Mechanisms of Fibromyalgia,” The Clinical Journal of Pain 7, suppl 1 (1991): S8–15. 16. P. Geppetti, R. Nassini, S. Materazzi, and S. Benemei, “The Concept of Neurogenic Inflammation,” British Journal of Urology International 101, Suppl. 3 (March 2008): 2–6. 17. Meggs, “Neurogenic Inflammation and Sensitivity,” 234–38. 18. Ibid; Geppetti, Nassini, Materazzi, and Benemei, “The Concept of Neurogenic Inflammation,” 2–6. 19. Meggs, “Neurogenic Inflammation and Sensitivity,” 234–38. 20. Ibid. 21. D. J. Chew and C. A. T. Buffington, “Non-Obstructive Idiopathic/Interstitial Cystitis in Cats: Thinking Outside the (Litter) Box,” WSAVA Congress proceedings (Sydney, Australia, 2007), http://www.vin.com/proceedings/Proceedings.plx?CID=WSAVA2007&PID=18243&O=Generic (accessed 14 Oct 2009). 22. Stein, Heal Pelvic Pain, 129. 23. J. Cangiano, “Pelvic Floor Dysfunction and Interstitial Cystitis,” Interstitial Cystitis Advice (October 2006), http://www.icadvice.com/node/26 (accessed 10 January 2009). 24. R. Moldwin, The Interstitial Cystitis Survival Guide: Your Guide to the Latest Treatment Options and Coping Strategies (Oakland, CA: New Harbinger Publications, 2000), 50–51. 25. C. Levine, “Pelvic Floor Health: Strengthening Your Core,” Women to Women.com. http://www.womentowomen.com/urinaryincontinence/pelvicfloorhealth.aspx (accessed 20 March 2010). 26. D. Wise and R. Anderson, A Headache in the Pelvis: A New Understanding and Treatment for Prostatitis and Chronic Pelvic Pain Syndromes (Occidental, CA: National Center for Pelvic Pain, 2003). 27. Stein, Heal Pelvic Pain, 129. 28. A. Willis, “Solving the Interstitial Cystitis Puzzle: A Guide to Natural Healing,” rev. and exp. ed. (Los Angeles, CA: Holistic Life Enterprises, 2006). Chapter 8: Help with Hormones and Alleviating Feminine Discomfort 1. F. R. Jelovsek, “Urinary Frequency and Urgency Problems,” Women’s Health Resource FAQ, http://www.wdxcyber.com/murfreq.htm (accessed 14 October 2009); E. Vliet, Screaming to Be Heard: The Hormonal Connection Women Suspect and Doctors Still Ignore. rev. and exp. ed. (New York: M. Evans and Company, 2001), 311–14. 2. Vliet, Screaming to Be Heard, 311–14; C. Northrup, The Wisdom of Menopause: Creating Physical and Emotional Health During the Change, rev. ed. (New York: Bantam, 2006): 133. 3. Vliet, Screaming to Be Heard, 311–14. 4. Ibid. 5. Ibid; Northrup, The Wisdom of Menopause, 63. 6. Northrup, The Wisdom of Menopause, 116–18. 7. B. Reed, “Vulvodynia: Diagnosis and Management,” American Family Physician 73 (2006): 1231–39. 8. J. T. Sutton, G. A. Bachmann, L. D. Arnold, G. G. Rhoads, and R. C. Rosen, “Assessment of Vulvodynia Symptoms in a Sample of U.S. Women: A Follow-up National Incidence Survey,” Journal of Women’s Health 17, no. 8 (1 October 2008): 1285–92. 9. Reed, “Vulvodynia: Diagnosis and Management,” 1231–39. 10. D. Foley, “Help for Intimate Pain,” Prevention Magazine, November, 2007, http://www.prevention.com/health/health/health-concerns/what-causes-pelvic-or-sexualpain/article/09b983e5a71f4110VgnVCM20000012281eac____/ (accessed 10 January 2009). 11. Reed, “Vulvodynia: Diagnosis and Management,” 1231–39. 12. American Congress of Obstetricians and Gynecologists. “About Vulvodynia,” http://www.acog.org/publications/patient_education/bp127.cfm (accessed 13 March 2010). 13. Reed, “Vulvodynia: Diagnosis and Management,” 1231–39. 14. C. Vasey, The Acid-Alkaline Diet for Optimum Health: Restore Your Health by Creating pH Balance in Your Diet, rev. 2nd ed. (Rochester, Vermont: Healing Arts Press, 2006). 15. Reed, “Vulvodynia: Diagnosis and Management,” 1231–39. 16. L. A. Boardman, A. S. Cooper, L. R. Blais, and C. A. Raker, “Topical Gabapentin in the Treatment of Localized and Generalized Vulvodynia,” Obstetrics and Gynecology 112, no. 3 (September 2008): 579–85. Chapter 9: Fighting the Role of Adrenal Fatigue for Improved Health 1. R. Moldwin, The Interstitial Cystitis Survival Guide: Your Guide to the Latest Treatment Options and Coping Strategies (Oakland, CA: New Harbinger Publications, 2000) 182. 2. J. Teitelbaum, Pain Free 1-2-3: A Proven Program for Eliminating Pain Now (New York: McGraw-Hill, 2005); S. K. Lutgendorf, K. J. Kreder, N. E. Rothrock, A. Hoffman, C. Kirschbaum, E. M. Sternberg, M. B. Zimmerman, and T. L. Ratliff, “Diurnal Cortisol Variations and Symptoms in Patients with Interstitial Cystitis,” The Journal of Urology 167, no. 3 (2002): 1338–43. 3. Lutgendorf, Kreder, Rothrock, Hoffman, Kirschbaum, Sternberg, Zimmerman, and Ratliff, “Diurnal Cortisol Variations,” 1338–43. 4. J. L. Wilson, Adrenal Fatigue: The 21st Century Stress Syndrome (Petaluma, CA: Smart Publications, 2002) 265–66. 5. Lutgendorf, Kreder, Rothrock, Hoffman, Kirschbaum, Sternberg, Zimmerman, and Ratliff, “Diurnal Cortisol Variations,” 1338–43. 6. Ibid. 7. Ibid. 8. J. L. Westropp, K. A. Welk, and C. A. T. Buffington, “Small Adrenal Glands in Cats with Feline Interstitial Cystitis,” The Journal of Urology 170 (December 2003): 2494–97. 9. T. Buffington quoted in S. Reinberg, “Painful Pelvic Disorder Linked to Small Adrenal Glands: Findings Could Lead to New Treatments for Women with Interstitial Cystitis,” http://www.paktribune.com/news/index.shtml?159495 (accessed 6 Feb 2009). 10. R. Bercik quoted in S. Reinberg, “Painful Pelvic Disorder Linked to Small Adrenal Glands: Findings Could Lead to New Treatments for Women with Interstitial Cystitis,” http://www.paktribune.com/news/index.shtml?159495 (accessed 6 Feb 2009). 11. C. A. T. Buffington, “Comorbidity of Interstitial Cystitis with Other Unexplained Conditions,” The Journal of Urology 172 (October 2004): 1242–48. 12. D. J. Chew and C. A. T. Buffington, “Non-Obstructive Idiopathic/Interstitial Cystitis in Cats: Thinking Outside the (Litter) Box,” WSAVA Congress proceedings (Sydney, Australia, 2007), http://www.vin.com/proceedings/Proceedings.plx?CID=WSAVA2007&PID=18243&O=Generic (accessed 14 Oct 2009). 13. Ibid. 14. Ibid. 15. Westropp, Welk, and Buffington, “Small Adrenal Glands in Cats,” 2494–97; J. Teitelbaum, Pain Free 1-2-3: A Proven Program for Eliminating Pain Now. 16. Westropp, Welk, and Buffington, “Small Adrenal Glands in Cats,” 2494–97. 17. Wilson, Adrenal Fatigue, 247. 18. Moldwin, The Interstitial Cystitis Survival Guide, 182. 19. C. Spanos, X. Pang, K. Ligris, R. Letourneau, L. Alferes, N. Alexacos, G. R. Sant, and T. C. Theoharides, “Stress-Induced Bladder Mast Cell Activation: Implications for Interstitial Cystitis,” The Journal of Urology 157 (1997): 669–72. 20. W. M. Jeffries, Safe Uses of Cortisol, 2nd ed. (Springfield, Illinois: Charles C. Thomas, 1981) 105–06. 21. Wilson, Adrenal Fatigue, 247. 22. Wilson, Adrenal Fatigue, 156–60. 23. C. O’Leary, C. H. Walsh, P. Wieneke, P. O’Regan, B. Buckley, D. J. O’Halloran, J. B. Ferriss, E. M. M. Quigley, P. Annis, F. Shanahan, and C. C. Cronin, “Coeliac Disease and Autoimmune Addison’s Disease: A Clinical Pitfall,” Quarterly Journal of Medicine 95 (2002): 79–82; C. Betterle, F. Lazzarotto, A. C. Spadaccino, D. Basso, M. Plebani, B. Pedini, C. Chiarelli, and M. Albergoni, “Celiac Disease in North Italian Patients with Autoimmune Addison’s Disease,” European Journal of Endocrinology 154, no. 2 (2006): 275–79. 24. C. Counsell, A. Taha, and W. S. Ruddell, “Coeliac Disease and Autoimmune Thyroid Disease,” Gut 35, no. 6 (1994): 844–46. 25. Wilson, Adrenal Fatigue, 247. 26. C. Northrup, The Wisdom of Menopause: Creating Physical and Emotional Health During the Change, rev. ed. (New York: Bantam, 2006) 110. 27. Ibid; M. J. Ghen and C. B. Moore, “Implications of Adrenal Insufficiency,” Biopathics.com, http://hereisyoursite.us/www.biopathics.com/BioPDFs/Adrenal_Insufficiency.pdf (accessed 18 March 2010). 28. Ghen and Moore, “Implications of Adrenal Insufficiency.” 29. Ibid. 30. 5. M. Moore, Herbs for the Urinary Tract, (New Canaan, CT: Keats Publishing, Inc., 1998), Chapter 10: The Embattled Body 1. J. W. Warren, “Interstitial Cystitis as an Infectious Disease,” Urologic Clinics of North America 21, no. 1 (February 1994): 31–39. 2. F. C. Burkhard, “Urinary Urgency and Frequency, and Chronic Urethral and/or Pelvic Pain in Females. Can Doxycycline Help?” The Journal of Urology 172, no. 1 (July 2004): 232– 35. 3. Ibid. 4. J. Coomer, “Vanderbilt Researchers Discover Potential Link Between C. Pneumoniae and Interstitial Cystitis,” Reporter (11 May 2001), http://www.mc.vanderbilt.edu/reporter/index.html?ID=1510 (accessed 25 September 2009). 5. N. Humphrey, “Chlamydia Pneumoniae Not Caught Like You Thought,” Reporter, Vanderbilt Medical Center’s Weekly Newspaper (23 April 1999), http://www.mc.vanderbilt.edu/reporter/index.html?ID=779 (accessed 21 March 2010). 6. M. Paldanius, A. Bloigu, M. Alho, M. Leinonen, and P. Saikku, “Prevalence and Persistence of Chlamydia Pneumoniae Antibodies in Healthy Laboratory Personnel in Finland,” Clinical and Diagnostic Laboratory Immunology 12, no. 5 (2005 May): 654–59. 7. Coomer, “Vanderbilt Researchers Discover Potential Link.” 8. Humphrey, “Chlamydia Pneumoniae Not Caught Like You Thought.” 9. Ibid; S. Sriram, C. W. Stratton, S. Yao, A. Tharp, L. Ding, J. D. Bannan, and W. M. Mitchell, “Chlamydia Pneumoniae Infection of the Central Nervous System in Multiple Sclerosis,” Annals of Neurology 46, no. 1 (1999): 6–14. 10. C. W. Stratton quoted in Humphrey, “Chlamydia Pneumoniae Not Caught Like You Thought.” 11. J. Kepner, “Chlamydia Pneumoniae in Chronic Fatigue Syndrome and Fibromyalgia,” Chlamydia Pneumoniae Help and Treatment, http://www.cpnhelp.org (accessed 14 October 2009). 12. S. Mazzoli, A. Salvi, F. Guercini, M. Marongiu, A. Raugei, S. Ospedale, and M. Annunziata, “Chlamydia Pneumoniae as an Impacting Emerging Pathogen in Prostate Pathologies,” Journal of Lipid Research 44 (December 2003): 2339–48. 13. “Lyme Disease Symptoms,” Canadian Lyme Disease Association, http://www.canlyme.com/patsymptoms.html (accessed 18 March 2010). 14. Ibid. 15. M. Haarala, P. Kiiholma, M. Nurmi, J. Uksila, and A. Alanen, “The Role of Borrelia Burgdorferi in Interstitial Cystitis,” European Urology 2000 37, no. 4 (April): 395–99. 16. S. Czub, P. H. Duray, R. E. Thomas, and T. G. Schwan, “Cystitis Induced by Infection with the Lyme Disease Spirochete, Borrelia Burgdorferi, in Mice,” American Journal of Pathology. 141, no. 5 (November 1992): 1173–79. 17. Haarala, Kiiholma, Nurmi, Uksila, and Alanen, “The Role of Borrelia Burgdorferi in Interstitial Cystitis.” 18. Canadian Lyme Disease Association, “Lyme Disease Symptoms,” http://www.canlyme.com/patsymptoms.html (accessed 18 March 2010). 19. Centers for Disease Control and Prevention, “Lyme Disease—Lyme Disease Diagnosis,” http://www.cdc.gov/ncidod/dvbid/lyme/ld_humandisease_diagnosis.htm (accessed 14 October 2009). 20. S. Yuan, Handbook of Diseases: Signs and Symptoms, Diagnosis, Treatment, 3rd ed. (Ambler, PA: Lippincott Williams & Wilkins, 2004). 21. American Lyme Disease Foundation. “Lyme Disease,” (2006, updated January 2010), http://www.aldf.com/lyme.shtml (accessed 21 March 2010). 22. P. C. Watkins, “Seven Diseases Doctors Miss Most,” Redbook magazine (July 1997), http://www.mvprolapse.com/article_seven.html (accessed 18 March 2010). 23. L. Mayer and S. Merz, “An Appraisal of ‘Chronic Lyme Disease,” The New England Journal of Medicine 358, no. 4 (24 January 2008): 428–31, http://search.nejm.org/search?w=Mayer+Lyme+Disease+Letter+to+the+Editor&search=SEARC H (accessed 18 March 2010). 24. M. E. Adelson, R. S. Rao, R. C. Tilton, K. Cabets, E. Eskow, L. Fein, J. L. Occi, and E. Mordechai, “Prevalence of Borrelia burgdorferi, Bartonella spp., Babesia microti, and Anaplasma phagocytophila in Ixodes scapularis Ticks Collected in Northern New Jersey,” Journal of Clinical Microbiology 42, no. 6 (June 2004): 2799–801. 25. H. M. Feder, B. J. B. Johnson, S. O’Connell, E. D. Shapiro, A. C. Steere, G. P. Wormer, and the Ad Hoc International Lyme Disease Group, “A Critical Appraisal of ‘Chronic Lyme Disease,’” The New England Journal of Medicine 357, no. 14 (October, 2007): 1422–30; M. S. Klempner, L. T. Hu, J. Evans, C. H. Schmid, G. M. Johnson, R. P. Trevino, D. Norton, L. Levy, D. Wall, J. McCall, M. Kosinski, and A. Weinstein, “Two Controlled Trials of Antibiotic Treatment in Patients with Persistent Symptoms and a History of Lyme Disease,” The New England Journal of Medicine 345 (2001): 85–92. 26. Yuan, Handbook of Diseases. 27. Ibid. Chapter 11: Other Sources of Pelvic Pain or Bladder Symptoms 1. R. A. Appell, ed., Voiding Dysfunction: Diagnosis and Treatment (New York: Humana Press, 2000) 140. 2. National Diabetes Information Clearinghouse (NDIC), “National Diabetes Statistics 2007,” http://diabetes.niddk.nih.gov/DM/PUBS/statistics (accessed 20 March 2010). 3. D. Mirkin, C. Murphy-Barron, and K. Iwasaki, “Actuarial Analysis of Private Payer Administrative Claims Data for Women with Endometriosis,” Journal of Managed Care Pharmacy 13, no. 3 (April 2007): 262–72; L. Mettler, V. Gaikwad, B. Riebe, and T. Schollmeyer, “Bladder Endometriosis: Possibility of Treatment by Laparoscopy,” Journal of the Society of Laparoendoscopic Surgeons 12, no. 2 (April–June 2008): 162–65; A. Babknia, Endometriosis: The 90s Outlook, Endometriosis FAQ, http://www.bioscience.org/books/endomet/endomet.htm (accessed 6 January 2009). 4. M. K. Chung, R. P. Chung, D. Gordon, and C. Jennings, “The Evil Twins of Chronic Pelvic Pain Syndrome: Endometriosis and Interstitial Cystitis,” Journal of the Society of Laparoendoscopic Surgeons 6, no. 4 (2002): 311–14. 5. F. R. Jelovsek, “Urinary Frequency and Urgency Problems,” Women’s Health Resource FAQ, http://www.wdxcyber.com/murfreq.htm (accessed 14 October 2009). 6. S. Yuan, Handbook of Diseases: Signs and Symptoms, Diagnosis, Treatment, 3rd ed. (New York: Lippincott Williams & Wilkins, 2004). 7. Jelovsek, “Urinary Frequency and Urgency Problems”; Mettler, Gaikwad, Riebe, and Schollmeyer, “Bladder Endometriosis: Possibility of Treatment by Laparoscopy.” 8. H. C. Guidone, “Bladder Endometriosis or IC?” (2000), http://www.hcgresources.com/bladder.html (accessed 6 January 2009). 9. O. L. Westney, C. L. Amundsen, and E. J. McGuire, “Bladder Endometriosis: Conservative Management,” The Journal of Urology 163, no. 6 (June 2000): 1814–17. 10. Guidone, “Bladder Endometriosis or IC?”; Babknia, Endometriosis: The 90s Outlook. 11. Guidone, “Bladder Endometriosis or IC?” 12. R. B. Albee, Jr., “Endometriosis and Suppressive Medications,” Center for Endometriosis Care, http://www.centerforendo.com/askcec.htm (accessed 6 January 2009). 13. D. Foley, “Help for Intimate Pain,” Prevention Magazine, November, 2007. http://www.prevention.com/health/health/health-concerns/what-causes-pelvic-or-sexualpain/article/09b983e5a71f4110VgnVCM20000012281eac____/ (accessed 10 January 2009). 14. Women’s Surgery Group, “Endometriosis Overview,” http://www.womenssurgerygroup.com/conditions/Endometriosis/overview.asp (accessed 20 March 2010). 15. V. H. Gonzalez-Quintero and F. E. Cruz-Pachano, “Preventing Adhesions in Obstetrics and Gynecological Surgical Procedures,” Reviews in Obstetrics and Gynecology 2, no. 1 (2009 Winter): 38–45. 16. H. Ellis, “The Clinical Significance of Adhesions: Focus on Intestinal Obstruction,” European Journal of Surgery—Supplement 577 (1997): 5–9. 17. Gonzalez-Quintero and Cruz-Pachano, “Preventing Adhesions in Obstetrics and Gynecological Surgical Procedures,” 38–45. 18. E. A. Borgfeldt, “Transvaginal Sonographic Ovarian Findings in a Random Sample of Women 25–40 Years Old,” Ultrasound in Obstetrics and Gynecology 13, no. 5 (1999 May): 345–50. 19. C. H. Nezhat, F. Nezhat, S. Borhan, D. S. Seidman, and C. R. Nezhat, “Is Hormonal Treatment Efficacious in the Management of Ovarian Cysts in Women with Histories of Endometriosis?” Human Reproduction 11, no. 4 (1996): 874–77. 20. Borgfeldt, “Transvaginal Sonographic Ovarian Findings,” 345–50. Angle Three Associates, Petition for Ovarian Cancer Awareness Postage Stamp, 21. http://www.ipetitions.com/petition/ovcastamp (accessed 19 March 2010). 22. P. Lavelle, “Ovarian Cancer: Warning Signs Often Missed,” (ABC Health and Wellbeing, 12 February 2004), http://www.abc.net.au/health/thepulse/stories/2004/12/02/1256123.htm (accessed 10 January 2009). 23. D. Grady, “Common Symptoms Could Be Warning Signs of Ovarian Cancer,” New York Times: Healthscience (13 July 2007), http://www.nytimes.com/2007/06/13/health/13ihtcancer.4.6128443.html (accessed 28 June 2010). 24. B. Goff quoted in Grady, “Common Symptoms Could Be Warning Signs.” 25. Lavelle, “Ovarian Cancer—Warning Signs Often Missed.” 26. Grady, “Common Symptoms Could Be Warning Signs.” 27. Goff quoted in Grady, “Common Symptoms Could Be Warning Signs.” 28. Lavelle, “Ovarian Cancer—Warning Signs Often Missed.” 29. Mayoclinic, “Ovarian Cancer: Symptoms,” (11 November 2008) http://www.mayoclinic.com/health/ovarian-cancer/DS00293/DSECTION=symptoms (accessed 19 March 2010). 30. Association for International Cancer Research (AICR), “Bladder Cancer FAQs” (2008), http://www.aicr.org.uk/BladderCancerFAQs.stm (accessed 19 March 2010). 31. Yuan, Handbook of Diseases. 32. Ibid. 33. Ibid. 34. E. Koldewijn, W. Hommes, F. Lemmens, F. Debruye, and P. Van Kerrebroeck, “Relationship Between Lower Urinary Tract Abnormalities and Disease-Related Parameters in Multiple Sclerosis,” The Journal of Urology 154, no. 1 (1995): 169–73. 35. Appell, Voiding Dysfunction: Diagnosis and Treatment. 36. Ibid. Chapter 12: Introducing Additional Therapeutic Techniques 1. S. Weiselfish-Giammatteo, Body Wisdom: Light Touch for Optimal Health (Berkeley, CA: North Atlantic Books, 2002). 2. F. A. Reeves, C. R. Chapple, and M. Pullman, “Success of Acupuncture in the Treatment of Painful Bladder Syndrome (Interstitial Cystitis),” The Journal of Urology 181, abstract 62 (2009): 23. 3. University of Pennsylvania Pain Medicine Center, Recruitment for Clinical Trials: “Acupuncture for the Treatment of Interstitial Cystitis (IC) Symptoms,” (2005), http://clinicaltrials.gov/ct2/show/NCT00094874?cond=%22Cystitis%2C+Interstitial%22&rank= 18 (accessed 12 March 2010). 4. C. Northrup, The Wisdom of Menopause: Creating Physical and Emotional Health During the Change, rev. ed. (New York: Bantam, 2006) 199. Chapter 13: What We Eat Matters—Other Diets to Consider 1. I. Flatow and D. Relman, “A Community of Thousands: In Your Gut,” Science Friday, National Public Radio, 21 November 2008, http://www.sciencefriday.com/program/archives/200811214 (accessed 14 October 2009). 2. K. Sullivan, interview by Wendy Cohan, March 2010. 3. L. Dethlefsen, S. Huse, M. L. Sogin, and D. A. Relman, “The Pervasive Effects of an Antibiotic on the Human Gut Microbiota, as Revealed by Deep 16S rRNA Sequencing,” http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0060280 (30 June 2010). 4. K. Scott, “Probiotics: Good Germs for Your Gut,” Living Without, (October–November 2008): 30–33. 5. D. Gates and L. Schatz, The Body Ecology Diet: Recovering Your Health and Rebuilding Your Immunity, 7th ed. (Bogard, GA: B.E.D. Publications, 2006). 6. Scott, “Probiotics: Good Germs for Your Gut.” 7. E. Gottschall, Breaking the Vicious Cycle: Intestinal Health Through Diet, rev. ed. (Baltimore, ON: Kirkton Press, 1994). 8. J. V. Joneja, Dietary Management of Food Allergies and Intolerances: A Comprehensive Guide (Burnaby, BC: J.A. Hall Publications, 1998). 9. Ibid.
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