PROGRESS IN BIOMEDICAL OPTICS AND IMAGING Vol. 3, No. 27 Optics in Health Care and Biomedical Optics: Diagnostics and Treatment Britton Chance Mingzhe Chen Gilwon Yoon Chairs/Editors 15-18 October 2002 Shanghai, China Sponsored by SPIE—The International COS—Chinese Society Optical Society for Optical Engineering Cooperating Organizations Shanghai Jiaotong University (China)* Beijing of Japan (Japan Society Institute of Technology (China)* Optical Society OSK—Optical Society of India OSI—Optical Society Applied Physics) AOS—Australian Optical Society of of Korea • • • • OITDA—Optoelectronic Industry Technology Development Association (Japan) KAPID—Korea OIDA—Optoelectronic Industry Development Association (USA) and • • PIDA—Photonics Industry & Association for Photonics Industry Development of Astronautics SPIE Asia-Pacific Chapters Association Chinese Development Society • • • Supported by National Natural Science Foundation of China Science and Technology • Shanghai • China Association for Committee for Science and Technology Shanghai Association for Science and Technology (China) Chinese-Americans (USA) of Optronics Magazine (Japan) Society (China) • • Electronic Chamber of Commerce • Professional Committee • • Photonics China on Optoelectronic Technology, Chinese Optical Society Published by SPIE—The International Society for Optical Engineering Proceedings of SPIE Volume 4916 SPIE is an international technical applications of society dedicated to advancing engineering and scientific optical, photonic, imaging, electronic, and optoelectronic technologies. Contents xi xiii SESSION 1 1 Symposium Committees Conference Committee NIR SPECTROSCOPY AND IMAGING I Hemodynamic measurements in rat brain combining diffuse near-infrared absorption and correlation spectroscopies [4916-30] G. Yu, T. Durduran, D. Furuya, J. H. Greenberg, A. G. Yodh, Univ. of Pennsylvania (USA) SESSION 2 9 NIR SPECTROSCOPY AND IMAGING II Application of integral transform algorithms to high-resolution reconstruction inhomogeneities in medical diffuse optical tomography [4916-41] of tissue A. B. Konovalov, Russian Federal Nuclear Ctr.; V. V. Lyubimov, Research Institute for Laser Physics (Russia); I. I. Kutuzov, Russian Federal Nuclear Ctr.; 0. V. Kravtsenyuk, A. G. Murzin, Research Institute for Laser Physics (Russia); G. B. Mordvinov, Russian Federal Nuclear Ctr.; L. N. Soms, Research Institute for Laser Physics (Russia); L. M. Yavorskaya, Russian Federal Nuclear Ctr. 22 Phase cancellation system for tumor imaging using targeted fluorescent contrast [4916-115] agents Y. Chen, L. Zhou, C. Mu, X. Intes, Univ. of Univ. School of Medicine 30 Application of LED Pennsylvania (USA); S. I. Achilefu, Washington (USA); B. Chance, Univ. of Pennsylvania (USA) imager for breast cancer diagnosis [4916-113] J. Zhang, Y. Lin, S. Nioka, Univ. of Pennsylvania (USA); N. O'Connor, B. Czerniecki, E. F. Conant, Univ. of Pennsylvania Hospital (USA); B. Chance, Univ. of Pennsylvania (USA) SESSION 3 37 TUMOR DIAGNOSIS AND TREATMENT I Selective photothermal laser-tissue interaction with augmentation of immunoadjuvants in treatment of DMBA-4 metastatic mammary tumors in rats (Invited Paper) [4916-10] W. R. Chen, Univ. of Central Oklahoma (USA) and Univ. of Oklahoma (USA); H. Liu, Univ. of Oklahoma (USA); R. F. Wolf, Univ. of Oklahoma Oklahoma State Univ. College of of Oklahoma, Inc. (USA) Veterinary Health Sciences Ctr. Medicine (USA); R. E. (USA); M. D. Lucroy, Nordquist, Wound Healing 43 Improvement of tumor 53 Effect of anti-cancer medicament on the validity of fluorescence-based technique for cancer diagnosis [4916-42] R. Zheng, Ocean Univ. of Qingdao (China); X. Z. Guo, Jilin Univ. (China); J. Wang, Ocean Univ. of Qingdao (China); W. N. Man, Jilin Univ. (China); R. Wang, J. W. Meng, Ocean Univ. of response to photodynamic therapy by manipulation of tumor oxygenation in an in-vivo model system [4916-45] Q. Chen, Z. Huang, H. Chen, H. Shapiro, J. Beckers, F. W. Hetzel, HealthONE Alliance (USA) Qingdao (China) iii SESSION 4 58 LIGHT-TISSUE INTERACTION 1 Tissue structure at analysis optical immersion (Invited Paper) [4916-116] V. V. Tuchin, Saratov State Univ. (Russia) 68 Reflective angular spectrum of biological-tissue-embedded slab focus [4916-07] J. C. Lai, Z. H. Li, A. Z. He, Nanjing Univ. of Science and Technology (China) 75 Optical properties of porcine nasopharynx tissue in vitro [4916-08] B. H. Li, Zhejiang Univ. (China) and Fujian Teachers Univ. (China); 81 S. S. Two-photon Xie, W. J. Su, Fujian Teachers excitation of hypocrellin (China); Z. K. Lu, Zhejiang Univ. (China) Univ. A [4916-09] J. Liu, Y. W. Zhao, Institute of Chemistry (China) and Chinese Academy of Sciences; J. Q. Zhao, A. D. Xia, L. J. Jiang, Institute of Chemistry (China) 88 Detecting photoacoustic signals with a probing ultrasound Yao, D. Xing, Y. G. Zeng, South China Normal Univ. beam [4916-11] Y. 95 Optical fiber fluorescent thermometry for electromagnetically induced heating in medicine treatment [4916-12] D. P. SESSION 5 98 INSTRUMENTATION AND APPLICATION Design of Y. 103 Jia, L. M. Zhao, S. P. Cui, Y. W. Lin, Shenyang Univ. of Technology (China) Liu, new type of reflectance pulse oximetry sensor [4916-13] J. G. Zhu, Y. H. Luo, Tianjin Univ. (China) Simplified laser fluorescence scanner for proteomics studies and early cancer diagnosis [4916-14] B. C. Kim, J. H. Jeong, Biomed Photonics Inc. (Korea); D. S. Jeong, BodiTech Inc. (Korea); E. Y. Choi, BodiTech Inc. (Korea) and Hallym Univ. (Korea); J. H. Kim, K. B. Nahm, Biomed Photonics Inc. (Korea) and Hallym Univ. (Korea) 109 In-vivo usable chemiluminescence probe carried by nanoparticles [4916-16] M. Hao, D. Xing, J. Wang, Y. H. He, South China Normal Univ. 115 Rugged hollow fiber for the infrared and its use in laser lithotripsy [4916-17] K. Iwai, Y.-W. Shi, Y. Matsuura, M. Miyagi, Tohoku Univ. (Japan) 120 Analysis and designs of a S. F. Dong, Xi'an Institute SESSION 6 128 3- and 2-fjm cascade Ho3+: ZBLAN fiber laser [4916-18] Optics and Precision Mechanics (China) and Air Force Engineering Univ. (China); G. F. Chen, X. H. Wang, W. Zhao, Y. S. Wang, Air Force Engineering Univ. (China) cw of CLINICAL DIAGNOSIS AND TREATMENT Highly sensitive chemiluminescence analysis system for medical radiation dose evaluation [4916-21] X. Li, Y. D. Wei, D. Xing, Y. H. He, South China Normal Univ. iv 134 Rapid and sensitive immunomagnetic-electrochemiluminescent detection of human lung cancer cell [4916-22] G. H. 140 Yan, D. B. Zhu, D. Xing, Military on erythrocyte membranes [4916-23] Medical Univ. (China) and Nanjing Univ. of Science and Technology Duan, L. G. Li, Second Military Medical Univ. (China); S. Univ. of Science and Technology (China); J. Y. Xu, H. Liu, Y. L. Yan, J. Shen, Second Military Medical Univ. (China) (China); 143 protein from S. C. Tan, South China Normal Univ. Influence of low-level laser radiation X. S. Luo, Second P53 P. M. Gao, X. W. Ni, J. G. Liu, Nanjing J. H. Ma, Active noncontact tonometer for glaucoma detection [4916-24] Y. Han, P. J. Bryanston-Cross, W. K. Lee, Univ. of Warwick (UK); M. Hero, Coventry and Warwick Hospital (UK) SESSION 7 151 LIGHT-TISSUE INTERACTION II Depolarization of N. Ghosh, P. K. 157 light in turbid medium: effect of collection geometry [4916-02] Gupta, H. S. Patel, B. Jain, B. N. Singh, Ctr. for Advanced Technology Theoretical study on light distribution in biological Y. Liu, Y. H. Luo, Y. Ni, J. G. Zhu, K. X. 165 Experimental research Z. H. Li, J. C. Lai, C. Y. 172 Xu, Tianjin strong absorption [4916-03] (China) tissue with Univ. depolarization property of layered biological tissues [4916-04] Wang, A. Z. He, Nanjing Univ. of Science and Technology (China) on Measurement of the refractive index of biotissue at four laser S. Y. (India) wavelengths [4916-05] (China) and Fuzhou Univ. (China); H. Y. Shen, G. Zhang, C. H. Huang, X. J. Huang, Fujian Institute of Research on the Cheng, Fujian Institute of Research on the Structure of Matter Structure of Matter (China) 177 SESSION 8 185 Angular spectrum distribution in biological tissues [4916-06] J. C. Lai, Z. H. Li, A. Z. He, Nanjing Univ. of Science and Technology (China) OPTICAL DIAGNOSIS AND SPECTROSCOPY 1 Multiple diagnosis based on photoplethysmography: hematocrit, Sp02l pulse, and respiration (Invited Paper) [4916-26] G. W. Yoon, J. Y. Lee, K. J. Jeon, K. K. Park, H. S. Yeo, H. T. Hwang, H. S. Kim, 1. D. Hwang, Samsung 189 Advanced Institute of Technology (Korea) Near-infrared spectroscopy to measure milk constituents and its reliability design [4916-27] L. J. Wang, Harbin Univ. of Science and Technology (China); D. W. Zhou, K. X. Xu, Tianjin Univ. (China); J. Y. Guo, Harbin Univ. of Science and 194 Emissive spectral analysis applied Technology (China) in 15N excretion test of Helicobacter pylori [4916-28] Y. Y. Zhu, Suzhou Univ. (China); J. C. Wu, Z. H. Zhang, Shanghai Second Medical Univ. (China) SESSION 9 197 OPTICAL IMAGING Whole-body fluorescent imaging of tumor cells transfected with EGFP [4916-36] Y. Jin, D. Xing, South China Normal Univ. V 202 Polarization-gated optical imaging: N. Ghosh, P. K. 210 Shen, Fujian Teachers SESSION 10 Singh, parameter of scatterer [4916-37] Technology (India) Ctr. for Advanced Univ. (China) Optical image quality improvement based tissues [4916-39] C.-W. Sun, C. C. Yang, Y.-W. 221 B. N. Novel optical imaging system for localization of early nasopharyngeal carcinoma [4916-38] S. S. Xie, B. H. Li, Fujian Teachers Univ. (China); Q. Ye, Fujian Provincial Hospital (China); G. P. 217 effect of size Gupta, H. S. Patet, Kiang, on time-resolved Stokes vectors in filamentous National Taiwan Univ. Signal compensation of photoacoustic tomography [4916-40] Y. G. Zeng, D. Xing, Y. Yao, South China Normal Univ. OPTICAL DIAGNOSIS AND SPECTROSCOPY II ___ 227 Autofluoresence spectroscopy for in-vivo diagnosis of human oral carcinogenesis [4916-31] C.-Y. Wang, l-Shou Univ. (Taiwan China); T. M. Tsai, Taipei Medical Univ. (Taiwan China); H.-M. Chen, National Taiwan Univ. College of Medicine; Y.-S. Kuo, National Taiwan Univ. School of Dentistry; C.-T. Chen, C.-P. Chiang, National Taiwan Univ. College of Medicine 234 Medical noncontact blood-sampling laser instrument [4916-34] Z. Ren, G. B. Ning, G. Y. Jin, G. C. Song, X. Y. Yan, Z. Liang, Changchun Univ. of Science and Technology (China) SESSION 11 OCT 241 Tissue clearing of biotissues for optical coherence tomography (Invited R. K. K. Wang, Cranfield Univ. (UK) and Tianjin Univ. (China) 245 Analysis of speckle in optical coherence tomography [4916-49] Y. An, J. Q. Yao,; R. K. K. Wang, Tianjin Univ. (China) and Huazhong Univ. of Science and Technology (China) 251 Image quality improvement with dispersion compensation and retrieval algorithms coherence tomography [4916-50] l-J. Hsu, C.-W. Sun, C.-W. Lu, C. C. 255 Biomedical application Yang, C.-P. Chiang, in optical C.-W. Lin, National Taiwan Univ. of OCT technology [4916-51] G. Kou, Nanjing Univ. of Science and 259 Paper) [4916-48] Technology (China) High-speed scanning optical coherence tomography [4916-52] Song, S. L. Jacques, Oregon Health and Science Univ. (USA) G. SSION 12 266 TUMOR DIAGNOSIS AND TREATMENT II and photobleaching properties of hematoporphyrin monomethyl ether [4916-43] Li, Zhejiang Univ. (China) and Fujian Teachers Univ. (China); Z. K. Lu, Zhejiang Univ. (China); S. S. Xie, Fujian Teachers Univ. (China) Spectral B. H. m\ 271 Rapid imaging of oxygen free radicals produced in PDT using FCLA chemiluminescence probe [4916-44] D. 280 Xing, J. Wang, Y. H, He, South China Normal Univ. Chemiluminescence from human Xing, X. J. Wang, D. 286 New serum albumin oxidation by singlet oxygen [4916-46] J. Hu, South China Normal Univ. photoacoustic technique for detection of Xing, Y. Yao, South China Normal breast H. B. Fu, D. cancer [4916-47] Univ. POSTER SESSION 293 Formulation of beam propagating through the organized tissues with polarization-sensitive OCT [4916-53] Y. Jiang, J. Science and 299 Q. Yao, R. K. K. Wang, P. Wang, Tianjin Univ. (China) and Huazhong Univ. of Technology (China) Optical properties of skin [4916-54] Y. X. Su, W. B. Wang, K. X. Xu, C. Z. Jiang, 305 Influence of medium parameters on Univ. (China) Tianjin the transmitted intensity and shape of ultrashort laser pulses [4916-55] K. H. Wu, G. L. Yang, Z. J. He, South China Normal Univ. 310 Propagation characteristics of autofluorescence in tissue [4916-56] H. B. Xie, X. D. Chen, Z. Xu, D. Y. Yu, 315 Development and application of Tianjin Univ. (China) new diode laser a therapy apparatus [4916-58] R. Chen, G. N. Chen, Fujian Teachers Univ. (China); M. Y. Ye, People's Hospital of Xianyou (China); L. G. Pan, First Affiliated Hospital of Fujian Medical Univ. (China); E. Cai, Affiliated People's Hospital of Fujian Herbal Univ. (China); L. Q. Xu, S. S. Xie, Fujian Teachers Univ. (China) 320 Application of D. F. the laser instrument in biomedicine [4916-59] Huang, Changchun Univ. of Science and Technology (China); T. Zhang, Changchun Institute of Optics, Fine Mechanics, and Physics (China); J. F. Zhou, Z. Y. Tang, Changchun Univ. of Science and Technology (China) 323 Y. Che, Optical manipulation of microscopic particles and biological cells by laser microbeams [4916-60] Y. Li, J. H. Liu, X. W. Meng, S. L. Zhang, Z. C. Zhang, Tsinghua Univ. (China) 329 Stereoscopic imaging technology for medical video endoscope [4916-61 ] D. Lu, Changchun Univ. of Science and Technology (China); P. Xiang, Changchun Industry Univ. (China); Y. Du, Changchun Univ. of Science and Technology (China) 335 Application of logarithmic analog operator with high-accuracy ratio in biochemical analyzer [4916-62] J. F. Wang, Z. H. Liu, J. X. Xiong, Changchun Univ, of Science Industry Co., Ltd. (China) and Technology (China); Y. S. Tan, Dalian 3280 Electronics 339 Novel W. K. microarray scanner [4916-63] Wang, M. Liu, Q. Q. Hu, Shanghai Institute of Optics and Fine Mechanics (China) Semiconductor laser cure instrument for brain blood oxygen [4916-64] Changchun Institute of Optics, Fine Mechanics, W. S. Wang, H. Y. Song, Y. Zhang, Y. X. Guo, and Physics (China); X, Dong, Harbin Neural Special Hospital (China) Monte Carlo simulation of measuring [4916-65] X. Q. Zhang, L. J. Xu, Nanyang capillary blood flow with diffused Univ. Technological (Singapore); Y. Liu, light correlation Univ. (China); Tianjin Y. J. Hock, Nanyang Technological Univ. (Singapore) Double-wavelength laser equipment for cosmetic skin resurfacing and treatment [4916-66] Zhang, Y. L. Li, G. H. Wang, Changchun Univ. of Science and Technology Y. L. Zhang, Z. Z. (China) Design of touchscreen control unit for medical Q-switched ruby laser X. Q. Wen, Z. S. Ye, Z. J. Jin, Experimental study Tianjin skin surface character on utilizing laser Doppler effect [4916-68] Zhang, Beijing Institute of Technology (China); Y. Ni, K. X. Xu, Tianjin Univ. (China); X. F. C. Z. Jiang, Tianjin Univ. (China) Design of a high-power semiconductor medical laser based [4916-69] W. D. Zou, M. Reflectivity for Chen, Y. Q. control selection of suitable light a source tonometer [4916-71] Y. Han, P. J. Warwick microprocessor on Gao, Nanchang Institute of Aeronautical Technology (China) of the human cornea and its influence on the a low-cost system [4916-67] Univ. (China) Bryanston-Cross, Hospital (UK) K. Shaw, Univ. of Warwick (UK); M. Hero, Coventry Low-cost multibeam optical tweezers with of cells [4916-72] Laguerre-Gaussian and mode and its manipulation X. Z. Feng, T. C. Zhu, Suzhou Univ. (China) Application of DWDM-OADM employed in a railway-area communication network [4916-73] Y. T. Huang, Xiamen Univ. (China); M. Chen, Fujian Normal Univ. (China); C. Chen, Xiamen Univ. (China) Clinical study on the treatment of anal eczema by semiconductor laser with traditional Chinese medicine steam washing [4916-74] E. W. Cai, Fujian Provincial People's Hospital (China); R. Chen, Fujian Normal Univ. (China) Diode laser irradiation treatment of thromboangitis obliterans [4916-75] R. Chen, Fujian Teachers Univ. (China); M. Y. Ye, People's Hospital of Xianyou (China); H. Y. Lin, L. Q. Xu, Fujian Teachers Univ. (China) Feasibility of laser and electromagnetism combined therapy in prostatitis [4916-76] R. Chen, L. Q. Xu, Y. P. Zheng, Fujian Teachers Univ. (China); A. Z. Lin, Second Hospital Fuzhou City (China); S. S. Xie, Fujian Teachers Univ. (China) of Mechanism study of intravascular low-level laser irradiation therapy [4916-77] Y. Q. Jiang, C. Y. Li, X. B. Wang, S. T. Jia, Shanxi Univ. (China) Chinese medicine photosensitizer stimulated [4916-78] Y. W. Ma, J. P. Li, D. Liang, by violet ray for L. N. Li, Zhejiang Univ. (China) early-stage cancer diagnosis 415 Q-switched Er:YAG radiation transmission through applications [4916-79] D. N. Papadopoulos, an oxide glass fiber for medical E. Papagiakoumou, A. A. Serafetinides, National Technical Univ. of Athens (Greece) 423 emission from the right and left hands [4916-80] Choi, H.-H. Jung, W. M. Woo, K.-S. Soh, Seoul National Samsung Advanced Institute of Technology (Korea) Biophoton C. H. 429 [Ca2+]i Univ. (Korea); G. W. Yoon, and MCLA-enhanced ultraweak chemiluminescence of macrophages irradiated with low-intensity He-Ne laser [4916-81] C. Y. Xu, D. Xing, S. C. Tan, X. Li, South China Normal Univ. 437 Construction of tissue autofluorescence spectra by Monte Carlo simulation [4916-82] X. D. Chen, H. B. Xie, Z. Xu, D. Y. Yu, Tianjin Univ. (China) 441 Correction of tissue autofluorescence by reflectance spectrum [4916-83] X. D. Chen, H. B. Xie, Z. Xu, D. Y. Yu, Tianjin Univ. (China) 445 Experimental investigation of the fluorescent spectra of human blood and its components [4916-85] Y. Q. Jiang, Shanxi Univ. (China) and Datong Medical College (China); C. Y. Li, X. B. Wang, S. T. Jia, Shanxi Univ. (China) 450 Noninvasive intracranial pressure measurement using near-infrared light [4916-87] L. Lin, G. Li, S. X. Xiang, J. F. Sun, Tianjin Univ. (China) 457 New advancement of noninvasive measurement of blood glucose by near-infrared spectroscopy [4916-88] Q. B. Li, Y. Wang, K. X. Xu, Tianjin Univ. (China) 465 Determination of instrumental precision requirement for expected glucose prediction accuracy [4916-89] Q. B. Li, X. T. Hu, K. X. Xu, Tianjin Univ. (China) 473 In-vivo determination of the absorbance spectra of human skin [4916-90] Q. Y. Li, Y. Wang, Y. L. Zhang, Jinan Univ. (China) 480 Laser-induced fluorescence detection system for microfluidic chip [4916-91] Y. Li, Z. F. Cen, X. T. Li, Z. K. Bao, Zhejiang Univ. (China) 484 Conditions and methods of high-precision measurement of blood mid-IR ATR spectroscopy [4916-94] J. W. Qin, D. W. Zhou, L. Zhang, Tianjin Univ. (China); Z. L. Lei, glucose concentration Shenyang using Scientific Instrument Development Ctr. (China); K. X. Xu, Tianjin Univ. (China) 490 Preliminary investigation of simultaneous by near-infrared spectroscopy [4916-95] measurement of multicomponents in human plasma X. L. Zhao, L. Zhang, Y. Wang, K. X. Xu, Tianjin Univ. (China); Y. Wang, K. Zhang, X. Q. Wang, Tianjin Hospital (China) 498 Noninvasive hemoglobin-measurement-based pulse oximetry [4916-97] Chewpraditkul, King Mongkut's Univ. of Technology/Thonburi (Thailand); W. Pothisarn, W. P. P. Yupapin, King Mongkut's Institute of Technology/Ladkrabang (Thailand) ix image capture and display system based endoscope [4916-99] Z. Sun, D. Y. Yu, J. Jiang, Tianjin Univ. (China) PCI bus for medical electronic 505 Real-time 510 Computer analysis method for determining protein relative molecular weight electrophoresis images [4916-100] on S. X. Zhang, W. L. Liu, D. G. Ran, J. C. Wang, X. X. Li, Hebei Univ. 515 Conformation and structure of extrusion polymer by the of in gel Technology (China) computed digital tomography image [4916-101] L. F. 522 Li, South China Univ. of Science and Real-time imaging spectrometry Technology for microscope [4916-103] L. Li, Chitose Institute of Science and Technology (Japan); K. Aizawa, (Japan); F. Ichikawa, Kawasaki Steel Techno-research Corp. (Japan) 528 Tokyo Medical Univ. Novel computer-based processing techniques for quantitative measurement of skin structures [4916-104] C. H. 536 Hu, Y. H. Xia, DSP-based data W. D. Liu, Yanshan Univ. acquisition and processing (China) system for OCT [4916-105] G. Li, W. Shao, K. J. Wu, L. Lin, Tianjin Univ. (China) 543 High-speed optical coherence tomography based on line scanning [4916-107] Tianjin Univ. (China) X. Jin, T. G. Liu, K. J. Wu, G. Li, 548 Author Index
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