Eight Righteous Zhi Zi - Gardenia Cool TCVM Thermal Nature: Cold Cool TCVM Indications: Damp Heat in the lower burner or Bladder Damp Heat Re-lin syndrome Frequent urination Urgent urination Hematuria Neutral Warm Hot Seemingly painful micturition with scant and redyellow urine Tongue: Red Pulse Slippery and rapid Chinese Principles of Treatment: Clear Heat and Fire in the Lower Jiao, eliminate Damp to drive through urinary dribbling. Contraindications: Stop administration immediately if the patient develops diarrhea, vomiting, or other unusual signs Dosage: Horse - 15 g twice daily as top dressing on feed Dog/Cat - 0.5 g per 10 to 20 lb body weight twice daily Ingredients and Actions: Latin Name Ingredients Actions Akebia Chuan Mu Tong Drains Damp and clears Heart Heat Dianthus Qu Mai Clears Heat and drains Damp in the Lower Jiao Plantago Che Qian Zi Clears Heat, cools Blood and stop hemorrhage Talcum Hua Shi Clears Heat and drains Damp Gardenia Zhi Zi Clears Heat and fire Rheum Da Huang Clears Heat and fire Juncus Deng Xin Cao Clears Heat Glycyrrhiza Gan Cao Harmonizes Distributed through veterinarians only www.tcvmherbal.com 9700 West Hwy 318, Reddick, FL 32686, USA [email protected] (800) 891-1986 (866) 700-8772 200-0.5g capsules 900g powder 100-0.2g capsules 200g powder 600g powder 200 teapills Main Herbs in Eight Righteous Eight Righteous (Ba Zheng San) comes from Tai Ping Hui Min He Ji Ju Fang (Imperial Grace Formulary of the Tai Ping Era) written by Chen Shi-Wen et al in 1080. Eight Righteous is designed to treat Heat and Dampness that has drained down to the urinary bladder. Chuan Mu Tong (Akebia) is the main herb in the formula which drains Damp-Heat out of the body. Qu Mai (Dianthus), Che Qian Zi (Plantago), Hua Shi (Talcum) and Deng Xin Cao (Juncus) serves as Minister herbs capable of clearing Damp-Heat and inducing diuresis. Zhi Zi (Gardenia) and Da Huang (Rheum) purge Fire and expel the pathogenic Heat out of the Lower Burner (Xia Jiao). Gan Cao (Glycyrrhiza) harmonizes the other ingredients and relieves spasms and pain, acting as the Messenger herb. Clinical Research on Eight Righteous Eight Righteous (Ba Zheng San) is the classical formula for treating a Bladder Damp-Heat pattern. Administration of Ba Zheng San had been associated with marked effect in numerous studies. In one study, 72 patients with urinary tract infection were treated with good results in clinical presentations, including frequent urination, urinary urgency, disuria, low back pain and fever.1 After treatment with Ba Zheng San of the 72 chronic prostatitis patients with damp-heat accumulated in the Lower Burner (Xia Jiao), the NIH-CPSI scores, TCM syndrome and EPS results were significantly improved.2 Another blinded controlled trial used three different TCM principles including Ba Zheng San on 218 patients with chronic prostatitis/chronic pelvic pain syndrome and showed a significant improvement on urinary tract symptoms after treatment with Ba Zheng San.3 Administration of modified Ba Zheng San was associated with a 91% success in 70 female patients with pyelonephritis. The study reported that out of 70 cases, 40 cases completely recovered, 26 cases have significant improvement, and 4 cases have no effect.4 Pharmaceutical Evidence of the Effects of Herbs in Eight Righteous Study showed that Ba Zheng San has effective antibacterial activity and all the Diplocous gonorrhoeae tested would be killed within ten minutes in vitro.5 The saponin and sapogenins extracted from the stem of Chuan Mu Tong (Akebia) exhibited significant antinociceptive and antiinflammatory effects in the rat. These effects were further supported by the reduction of carrageenan induced lipid peroxidation and hydroxy radical content in serum.6 One study detected 12 kinds of diuretic traditional Chinese medicines and demonstrated that all of the 12 herbs especially Qu Mai (Dianthus) had inhibitory activities for urogenital Chlamydia trachomatis in vitro.7 Zhi Zi (Gardenia) has been used in traditional medicine for the treatment of inflammatory disease. The hydrolyzed gel of Zhi Zi (Gardenia) extract, containing genipin, was effective for the treatment of ecchymoses in a rat model.8 Zhi Zi (Gardenia) extracts have been used for food colorant, medicine, feed and cosmetic.9 Che Qian Zi (Plantago) had a considerable anti-inflammatory and hepatoprotective activities.10 Case Study Dr. Constance A. DiNatale combined Chinese herbal medicine, acupuncture, Tui-na and food therapy together successfully to treat an 11 year old border collie with chronic urinary tract infections for 3 years.11 The dog displayed a slightly depressed Shen. Her coat was dry and had no body. There were depressions over BL 18 and BL 28. Her tongue was red and dry. Her pulses were slippery on the right and the left side felt thin, fast and thready. The TCVM diagnosis included three aspects, the first was Bladder Damp-Heat causing chronic urinary tract infections. Second was Kidney Yin Deficiency. The third is focal areas of stagnation. The TCVM treatment plan was using Ba Zheng San to drain Damp and clear Heat from the Bladder and to relieve pain. Another formula Zhi Bai Di Huang Wan was prescribed to tonify Kidney Yin and clear Heat. Acupuncture points were dry needled for 20 minutes, at 3 week intervals, for 6 treatments initially. The owner was instructed to do Tui-na techniques and make homemade diet. In the next month, the owners were able to decrease the dose of Ba Zheng San. Over the past year since coming in as a patient, the dog looked very healthy and has wonderful energy and Shen. References 1. Ding, Y. Clinical study of Ba Zheng San for urinary tract infection. Neimenggu Zhong Yi Yao. 2012,5:15-6 [ in Chinese] 2. Chang, D.G. et al. Modified Ba Zheng San for urination symptoms of chronic prostatitis with damp-heat accumulated in the lower jiao. Zho ghua Nan Ke Xue. 2010, 16(7):664-8 [ in Chinese] 3. Zhang, M.J. et al. Clinical study on treatment of chronic prostatitis/chronic pelvic pain syndrome by three different TCM principles. Zhong Zhong Xi Yi Jie He Za Zhi. 2007,27 (11):989-92 [in Chinese] 4. Wang, X. et al. Modified Ba Zheng San for 70 cases of pyelonephritis. Jilin Zhong Yi Yao. 1989,4:21 [in Chinese] 5. Lu, H. et al. In vitro effects of ancient prescription Ba Zheng San against Diplococus gonorrhoeae. Zhong Yao Cai. 1998,21(3):147-8 [in Chinese] 6. Choi, J.et al. Antinociceptive and anti-inflammatory effects of the saponin and sapogenins obtained from the stem of Akebia quinata. J Med Food. 2005,8(1):78-85 7. Li, J.J. et al. Inhibitory activity of Dianthus superbus L. and 11 kinds of diuretic Traditional Chinese medicines for urogenital Chlamydia tr chomatis in vitro. Zhongguo Zhong Yao Za Zhi. 2000,25(10):628-30 [in Chinese] 8. Hwang, K. The effect of hydrolyzed gardeniae fructus extract hydrogel on the treatment of ecchymoses in a rat model. Dermatol Surg. 2009,35(10):1525-31 9. Ni, H.Y. et al. Research and development of Fructus Gardeniae. Zhongguo Zhong Yao Za Zhi. 2006,31(7):538-41 [in Chinese] 10. Türel, I. et al. Hepatoprotective and anti-inflammatory activities of Plantago major L. Indian J Pharmacol. 2009,41(3):120-4 11. DiNatale, C. A. Chronic urinary tract infections for 3 years in a 11 year old border collie. AJTCVM, 2009, 4(1):67-9