AquADEKs® Showed Improvements in Plasma Levels of Antioxidants in Clinical Studies Abstract Summaries: Study A: Papas KA, Sontag MK, Pardee C, Sokol RJ, Sagel SD, Accurso FJ, and Wagener JS. A pilot study on the safety and efficacy of a novel antioxidant rich formulation in patients with cystic fibrosis. JCyst Fibros. 2008;7(1):60-7. Why Should I Take AquADEKs® Everyday? Now with more D! Vitamin 10 CF subjects ages 8 to 45 years old were given 10ml of the prototype liquid for 56 days following a washout period of 21 days. Plasma was obtained at baseline, 1, 2, 4, and 8 weeks and assayed for beta-carotene, gamma-tocopherol, retinal, CoQ10, and for safety parameters. Pulmonary function was measured and induced sputum was assayed for markers of inflammation and quantitative bacterial counts. The formulation safely and effectively increased plasma levels of important fat-soluble nutrients and antioxidants. Improvements in antioxidant plasma levels were associated with reductions in airway inflammation in CF patients. Study B: Sagel, SD, Sontag MK, Anthony MM, Emmett P, Papas KA. Effect of an antioxidant-rich in supplement in cystic fibrosis. J Cyst Fibros. 2011;10:31-36. 14 CF subjects were given AquADEKs® softgels for 12 weeks in this open-label study. AquADEKs® increased systemic antioxidant levels while maintaining Vitamin A levels in the normal range and improved but did not completely normalize vitamin D and K status in all subjects. Increased B-carotene levels were associated with improved growth parameters. Study C: Sadowska-Woda I, Rachel M, Pazdan J, Bieszczad-Bedrejczuk E, Pawliszak K. Nutritional supplement attenuates selected oxidative stress markers in pediatric patients with Cystic Fibrosis. Nutr Res. 2011 Jul;31(7):509-18. 50 patients with CF and 21 healthy children were given vitamin supplementation for 12 weeks. Patients with CF initially showed increased levels of oxidative stress over the control group, which was reduced following supplementation with AquADEKs®. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. To order in the US, call 800-472-2634 or visit https://store.aptalispharma.com/Vitamins-and-Supplements/ AquADEKs® products are distributed by Aptalis Pharma (in the US and Canada) Also, all AquADEKs® products can be purchased from your local pharmacy although you may need to ask the pharmacist to order them for you if they do not have them in stock – they normally get them within a day or two. If you let the pharmacist know that you will be purchasing them regularly, they may keep AquADEKs® in stock for you. THE SCIENCE OF AquADEKs® Liquid: UPC# 3 58914 21460 1 • AquADEKs® Chewable Tablets: UPC# 3 58914 01460 7 • AquADEKs® Softgels: UPC# 3 58914 01106 4 For additional product information visit www.aquadeks.com YH 2014.05 All AquADEKs® products are manufactured under Good Manufacturing Practices (GMP) in FDA inspected facilities. AquADEKs® is a dietary supplement specifically formulated for the needs of those who have difficulty absorbing fat-soluble vitamins and nutrients.‡ ‡These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Improved Absorption of Vitamins A, D, E & K in AquADEKs® AquADEKs® is a multivitamin and mineral supplement designed to help increase absorption of fat-soluble vitamins A,D,E,K. AquADEKs® is formulated to meet specific nutritional needs of certain conditions that cause malabsorption of fat-soluble vitamins, such as pancreatic insufficiency and/or a diminished bile acid pool. Its development was supported by a Therapeutic Development Grant from the Cystic Fibrosis Foundation. In people with normal absorption, enzymes from the pancreas and bile from the liver help enable fat-soluble vitamins to to be used by the body. AquADEKs® uses a microsphere technology to aid absorption of fat-soluble vitamins A, D, E, K even when their absorption from food is impaired. This technology does more than break the larger fat globules into smaller globules. AquADEKs® actually aids absorption of the fatsoluble vitamins by enclosing them inside a micelle. What are Antioxidants and Why Might I Need More Antioxidants? Chewables Now with more D! Vitamin Softgels Pediatric Liquid (Black Cherry Flavored) AquADEKs® Chewables The pink swoosh in the upper left of the bottle label will indicate if the product contains the higher level of Vitamin D. AquADEKs® Liquid AquADEKs® Softgels Amt per 2 tablets % DV* Amt per 1 softgel Calories 15 - 5 - 10 Total Carbohydrates (g) 2 <1% - - 2 † - 18,167 363 70 Serving size Sugars (g) Amt per % DV* 2 softgels % DV* Amt per 1mL % DV* Infants Amt per 2mL % DV* <4 yrs - - - - - - - - - - - - - - - - - - 18,167 363 36,334 726 5,751 383 11,502 460 117 75 125 150 250 45 129 90 225 1,200 300 1,200 300 2,400 600 600 150 1,200 300 Antioxidants help protect healthy cells from damage caused by free radicals. Absorption issues and chronic infections can deplete antioxidants which are important for maintaining immunity and lung health. A healthy diet, including fruits and vegetables, supplemented by fat-soluble vitamins and antioxidants, can boost antioxidant levels. Vitamin A (IU) (as 92% beta-carotene and 8% palmitate)(as 87% beta-carotene and 13% palmitate in pediatric liquid) Vitamin C (mg) (as sodium ascorbate) (as sodium ascorbate and ascorbic acid in pediatric liquid) Vitamin D (IU) (as cholecalciferol) Why Should I Take AquADEKs® Everyday? Vitamin E (IU) (as d-alpha-tocopherol) 100 333 150 500 300 1,000 50 1,000 100 1,000 Vitamin K (mcg) (as phytonadione) 700 875 700 875 1,400 1,750 400 † 800 † Thiamin (mg) (as thiamin mononitrate) (as thiamine hydrochloride in pediatric liquid) 1.5 100 1.5 100 3 200 0.6 120 1.2 171 Riboflavin (mg) (as riboflavin 5”-phosphate sodium in pediatric liquid) 1.7 100 1.7 100 3.4 200 0.6 100 1.2 150 Pancreatic insufficiency and/or a diminished bile acid pool can result in the inability of the body to digest and absorb certain nutrients from food such as fats, proteins, carbohydrates, and fat-soluble vitamins. Impaired absorption from pancreatic insufficiency leads to deficiencies of fat-soluble vitamins A, D, E and K and antioxidants. AquADEKs® helps increase these key fat-soluble vitamins and antioxidants. Niacin (mg) (as niacinamide) 10 50 10 50 20 100 6 75 12 133 Vitamin B6 (mg) (as pyridoxine hydrochloride) 1.9 95 1.9 95 3.8 190 0.6 150 1.2 171 200 50 100 25 200 50 - - - - 12 200 12 200 24 400 - - - - Folic Acid (mcg) Vitamin B12 (mcg) (as cyanocobalamin) Biotin (mcg) Fat-soluble nutrients can not efficiently enter cells Fat-soluble nutrients from AquaADEKs enter cells 100 33 100 33 200 66 15 30 30 20 Pantothenic acid (mg) (as calcium d-pantothenate) 12 120 12 120 24 240 3 100 6 120 Zinc (mg) (as zinc amino acid chelate for chewables)(as zinc sulfate in softgels) (as zinc gluconate in pediatric liquid) 10 67 10 67 20 134 5 100 10 125 Selenium (mcg) (as selenomethionine, as sodium selenite in chewables) 75 107 75 107 150 214 10 † 20 † 10 <1 10 <1 20 1 10 † 20 † 30 † 80 † 160 † 15 † 30 † 10 † 10 † 20 † 2 † 4 † Sodium (mg) Vitamin E (mg) People with malabsorptive conditions lack the mechanisms for fat-soluble nutrients to efficiently enter cells to be utilized by the body. AquADEKs has been shown to facilitate absorption of the fat-soluble vitamins contained in it in two published clinical studies with malabsorbing individuals. (as other mixed tocopherols) Coenzyme Q10 (mg) *Percent daily values are based on a 2000 calorie diet. †Daily values not established for these nutrients. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Why Choose AquADEKs®? • AquADEKs® is formulated with microsphere technology for enhanced absorption of the fat-soluble vitamins contained in it • AquADEKs® vitamin absorption has been supported by published clinical studies • AquADEKs® development was supported by NIH & CFF Therapeutic Development Grants Vitamin A Vitamin D & K Vitamin B12 Selenium Vitamin E Coenzyme Q10 Beta-carotene supports lung function.* Vitamins D & K support bone health.* B12 supports brain and nervous system functioning.* Selenium to support the body’s own antioxidant system.* Mixed tocopherols for greater antioxidant activity.* Coenzyme Q10 supports heart function and promotes energy production in cells.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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