Cover Sheet for Bids (All sections must be completed) Name of JISC Initiative: Universities Modernisation Fund Cloud Computing Programme Name of Lead Institution: University of Leicester Name of Proposed Project: BRISSkit: Biomedical Research Infrastructure Software Service kit Name(s) of Project Partners(s) University Hospitals Leicester Trust (except commercial sector – see below) This project involves one or more commercial sector partners YES Name(s) of any commercial partner company(ies) Obiba Software Foundation; Charles Beagrie Consultants Full Contact Details for Primary Contact: Name: Dr Jonathan Tedds Position: Senior Research Liaison Manager Email: [email protected] Tel: 01162525287 Address: IT Services, Computer Centre, University of Leicester, Leicester LE1 7RH Length of Project: 12 months Project Start Date: 1st April 2011 Total Funding Requested from JISC: Project End Date: 31st March 2012 £816,096 Funding requested from JISC broken down across Financial Years (Apr-March) Apr11 – March12 £816,096 Total Institutional Contributions: £48,875 Outline Project Description BRISSkit will develop a national shared service brokered by JANET to host, implement and deploy biomedical research database applications that support the management and integration of tissue samples with clinical data and electronic patient records. We are uniquely positioned to tackle this through our experience in developing the pioneering open source IT infrastructure for the Biomedical Research Informatics Centre for Cardiovascular Science in the NIHR Leicester Cardiovascular Biomedical Research Unit (BRU). Anonymised versions of patient sensitive databases are hosted for University researchers on a VMware platform implemented by the University of Leicester IT Research Computing Service. We will work across the range of stakeholders in clinical, University and international biomedical research to deploy appropriate, secure, affordable and reliable services in this key strategic area for the UK. I have looked at the example FOI form at Appendix A YES and included an FOI form in this bid I have read the Funding Call and associated Terms and Conditions of Grant at Appendix B For FE institutions only: Please tick this box if you are an FE institution in England, please tick this box to confirm that you meet the eligibility requirement of teaching HE to more than 400 FTE o o 1 YES 1. University of Leicester IT Strategy and the JISC University Modernisation Fund Cloud Computing Programme 1.1. The University of Leicester (UoL) and University Hospitals Trust Leicester (UHL) believe that the effective management of research data is a critical success factor. We recognise the huge opportunity that could result from more effective sharing and dissemination of data across biomedical research disciplines and between institutions and other Hospital Trusts. We also note the potential of cloud based infrastructure and shared services to contain costs and are keen to demonstrate that these opportunities can be exploited in a secure manner without exposing our organisations to significant risk. We therefore warmly welcome the JISC University Modernisation Fund (UMF) Cloud Computing Programme and wish to build on current working prototypes created for our Biomedical Research Informatics Centre for Cardiovascular Science (BRICCS) project 1 to create a full production service in a shared services/cloud environment for the benefit of the whole biomedical research sector. 1.2. The University of Leicester has already taken a number of strategic actions to support the research data management needs of its researchers and promote the long-term preservation and dissemination of the data they produce. It has also given its central IT Service a clear mandate to provide comprehensive information management services to underpin all aspects of the University’s mission, including its research, in the most cost-effective manner possible. 1.3. Within the central IT Service, it has created a ‘Research Computing Services’ (RCS) team (in 2008) whose aim is to support the needs of researchers in particular. This is now staffed with six IT professionals (all with research backgrounds) and one full-time project manager. The team launched a new £2m High Performance Computing facility in 2010 and has gone on to pilot various server and database hosting services on a ‘local cloud’ of virtualised infrastructure including for the BRICCS project which is the subject of this proposal. 1.4. The University was a Pathfinder for the UK Research Data Service (UKRDS). This provided an excellent opportunity to engage a wide range of researchers in requirements gathering and generate enthusiasm for solving the data management challenge at Leicester. Through this initiative we have established the role of ‘Research Liaison Manager’ which has built effective relationships with a wide range of research teams and helped us to identify, define and prototype the services that they need at institutional level. One such example is the LAMP Hosting Service which provides a common infrastructure stack (Linux, Apache, MySQL and PHP) running on VMWare for hosting research applications. This is the proposed infrastructure for the project which is the subject of this proposal. 1.5. The services implemented or envisaged have been agreed within the regular governance structure of the institution through the Research Computing Management Group, chaired by the PVC Research & Enterprise (Prof Kevin Schurer) and its parent group the Information and Communications Technology Committee. 1.6. The Research Liaison Manager has also developed a keen understanding of the cultural issues and other inhibitors that could prevent the exploitation of services that are, or will be, available nationally or internationally. 1.7. The University’s governing body has also highlighted the need to ensure the integrity of its research data, particularly where that data is sensitive. Another key role of the IT Research Liaison Manager has been to map sensitive and confidential data across the institute in order to prioritise where intervention and support is needed most urgently and develop a co-ordinated and rigorous institutional policy having wider application nationally. 1 http://www2.le.ac.uk/projects/bru/researchers/briccs o o 2 1.8. The JISC MRD funded interdisciplinary HALOGEN project made a good template for effective partnership with the research community and successfully engaged the Wellcome Trust in practical endorsement of its aims. The HALOGEN project (History, Archaeology, Linguistics, Onomastics and GENetics) supported the data management needs of the researchers involved and thus provided a context in which to establish organisational best practice in terms of the storage and management of diverse crossdisciplinary research data. The project covered all phases of the project life cycle from requirements analyses through to the implementation of a practical, cost effective solution to meet the needs of the research team for data access, sharing, curation and preservation. The solution was designed to exploit the existing research storage assets within the University in terms of hardware, software and technical expertise both within IT Services and other centres of excellence within the University. Extensive use of DCC developed tools was made and, through collaboration with other Pathfinder institutions, policies, procedures and organisational constructs were implemented in an emerging coherent national framework. 2. The University Hospitals Leicester Trust (UHLT) and the BRICCS project 2.1. The Biomedical Research Informatics Centre for Cardiovascular Science (BRICCS): BRICCS is a core component of the NIHR Leicester Cardiovascular BRU, itself a joint initiative of the UoL and the UHLT2. BRICCS aims to capture and code clinical information about patients with cardiovascular disease seen in UHL specifically for research purposes and for facilitating recruitment of patients into new studies. A database of cardiovascular samples will be combined with patient records and related research data in a secure Hospitals Trust database. The University in turn hosts an anonymised mirror of this dataset for use by University researchers, updated nightly, using the LAMP Hosting Service originally designed for a smaller scale bioinformatics research computing cluster in Genetics and developed to support the JISC MRD Halogen database. BRICCS initial emphasis was on setting up sample tracking software and the storage and annotation of the data sets in a simple, user friendly form for a range of Trust and University researchers. 2.2. UHLT already collects a large amount of information on patients, both of a generic nature and more detailed information on specific groups of interest. BRICCS has developed a dedicated research database with a core set of information on each subject, including known cardiovascular conditions and risk factors, and establish linkages with other databases, including results of hospital investigations, to primary care and to national registers. The programme was rolled out initially over two years from late 2009. The Trust sees this development as a key component of its future R&D strategy and as a forerunner of similar developments in other disease areas. 2.3. The BRICCS development team is led academically by Prof Leong Ng who has considerable relevant experience, having developed the Leicester CCU research database over the last 15 years on over 10,000 subjects (e.g. Blackledge et al. BMJ 2003; Khan SQ et al. Circulation 2007). Prof Paul Burton who has vast experience in the design and harmonization of large scale databases and clinical biorepositories, including UK Biobank and FP6 funded PHOEBE project will play a key advisory role. A senior Trust manager with IMT expertise (Maureen Collins, seconded full-time) will manage the Trust team within project. 2.4. The Leicester Cardiovascular Bioresource (LCB) is being developed in parallel with BRICCS to collect and store plasma, DNA and other biological samples (e.g. vascular tissues) from selected groups of patients being investigated and treated in UHLT. It is planned to collect, in the first 5 years, in excess of 20,000 new samples, each linked to patient information available via BRICCS. Given its scale and the mixed ethnic population base, LCB will become a major resource, contributing both to our local programmes (particularly in genomics), as well as building national capacity in this field. 2.5. As in the case of BRICCS, development of LCB will be managed by a dedicated team headed by an academic (Prof Alison Goodall) and supported by a full-time scientific manager funded by the University (Manish Maisuria). LCB follows best practice for tissue banks, as defined in international guidelines such as those of the Confederation of Cancer Biobanks (http://www.ncri.org.uk/ccb). o o 3 3. Proposal and Work Plan 3.1. Project Objectives 3.1.1. The primary objective is to design, deliver and begin to exploit a data hosting service for researchers in the field of Bioinformatics. Sensitive, attributable clinical data will be hosted on infrastructure managed by UHLT. De-identified versions of this data will be replicated to a cloud based infrastructure and made available to researchers. This will establish best practice for similar initiatives both within the UoL/UHLT and nationally. 3.1.2. In achieving this, the following additional learning objectives will be met. A service delivery model and policies for supporting successful research using this approach will be established. The costs and benefits of undertaking research using this service will be established The strengths, weaknesses, threats and opportunities associated with using this approach will be assessed 3.2. Partners and Methodology The solution will be developed collaboratively to meet the requirements of the UoL Departments of Cardiovascular Sciences, Genetics & Health Sciences as well as the UHLT. Maximum benefit will also be gained by sharing experience with others notably the DCC and the other institutions who are part of the UMF cloud computing programme, brokered by Charles Beagrie Ltd. 4. Timetable of Technical Work Packages and Deliverables Months 04 05 06 07 08 Workpackage 11 11 11 11 11 WP1 – Project Management Project set-up and detailed project plan D1.1 Six monthly report and revised project plan JISC Programme level activity and reporting to funder; final report WP2 – Project infrastructure Code repository, automatic build system, D2.1 web sites, issue tracking Virtual Machine test facilities D2.2 WP3 – Deployment Infrastructure Deployment Architecture Document D3.1 Artifact repository for auto-deployment use D3.2 (project test version only) Generic System Administration Programs, D3.3 Scripts and Facilities for auto deployment 09 11 Revised Deployment Architecture Document 11 11 12 11 01 12 02 12 03 12 D1.2 D1.3 D3.4 WP4 – Tissue Management “in a box” (Target Application: caTissue) Developing the use case: submission of D4.1 multiple samples (already prototyped) Package the API developed in D4.1 so it is D4.2 o o 10 11 4 Months 04 05 06 07 08 09 10 Workpackage 11 11 11 11 11 11 11 extensible to other collection protocols Customization for the UK locale Deployment Scripts for auto deployment D4.4 Document the integration of laboratory D4.5 equipment Enable the grid aspect of caTissue WP5 – Data Capture “in a box” (Target Applications: Onyx and REDCap) Packaged Ontology D5.1 Principles and Practices of Questionnaire Design Document Package existing design tools (onyx GUI D5.3 questionnaire builder) Components for Data Export (driven by D5.4 Ontology) Deployment Scripts for auto deployment D5.5 WP6 – Data Capture from Clinical Systems (into the Data Warehouse) Define standard web services for export D6.1 Provide example web services for export / import Document use of the packaged ontology WP7 – Biomedical Data Warehouse “in a box” (Target Application: i2b2) Server side customization for the UK locale D7.1 Client customization for the UK locale: D7.2 workbench and web client Deployment Scripts for auto deployment D7.3 Enhance forthcoming ontology pull cell for UK, to use TRUD Component pipeline with web services for Data Import (driven by Ontology) WP8 - E3 “End-to-End engineering” Integration of caTissue with i2b2 D8.1 Revised Deployment Architecture Document for clinical contexts Revised deployment procedures for clinical contexts Glue scripts for complete end-to-end install of components Glue scripts for daily end-to-end running of the system Facilitating Data sharing – SHRINE WP9 – Evaluation and Deployment Workshop-1 with infrastructure providers. D9.1 Any one component. Deploy & use in day. Workshop-2 with domain users: Tissue Management. Deploy & use in day. Workshop-3 with domain users: Data Capture. Deploy & use in day. Workshop-4 with domain users: Data Warehouse. Deploy & use in day. o o 5 11 11 12 11 01 12 02 12 03 12 D4.3 D4.6 D5.2 D6.2 D6.3 D7.4 D7.5 D8.2 D8.3 D8.4 D8.5 D8.6 D9.2 D9.3 D9.4 Months Workpackage Workshop-5 with infrastructure providers. All components. Deploy & use in day. Setup repository and install components with infrastructure providers. Packaged documentation plus multimedia HOWTO videos. 4.1. 04 11 05 11 06 11 07 11 08 11 09 11 10 11 11 11 12 11 01 02 12 12 D9.5 03 12 D9.6 D9.7 List of Technical Deliverables D3.1: Deployment Architecture Document [end 31.5.11] D3.2: Artifact repository for auto-deployment use (project test version only) [end 13.5.11]. D3.3: Generic System Administration Programs, Scripts and Facilities for auto deployment [end 13.7.11] D4.1: Developing the use case: submission of multiple samples [end 27.7.11] D4.2: Package the API developed in D4.1 so it is extensible to other collection protocols [end 25.8.11] D4.3: Customization for the UK locale [end 28.12.11] D4.4: Deployment Scripts for auto deployment [end 28.6.11] D4.5: Document the integration of laboratory equipment [end 2.9.11] D4.6: Enable data sharing via grid for caTissue [end 5.1.12] D5.1: Packaged Ontology [end 29.9.11] D5.2: Principles and Practices of Questionnaire Design Document [end 1.12.11] D5.3: Package existing design tools [end 8.8.11] D5.4: Components for Data Export [end 5.9.11] D5.5: Deployment Scripts for auto deployment [end 4.7.11] D6.1: Define standard web services for export [end 5.8.11] D6.2: Provide example web services for export / import [end 2.11.11] D6.3: Document use of the packaged ontology [end 6.12.11] D7.1: Server side customization for the UK locale [end 5.8.11] D7.2: Client customization for the UK locale: workbench and web client [end 12.10.11] D7.3: Deployment Scripts for auto deployment [end 4.7.11] D7.4: Enhance forthcoming ontology pull cell for UK, to use TRUD [end 2.11.11] D7.5: Component pipeline with web services for Data Import (driven by Ontology) [end 9.1.11] D8.1: Integration of caTissue with i2b2 [end 8.9.11] D8.2: Revised Deployment Architecture Document for clinical contexts [end 10.2.12] D8.3: Revised deployment procedures for clinical contexts [end 10.2.12] D8.4: Glue scripts for complete end-to-end install of components [end 15.3.12] D8.5: Glue scripts for daily end-to-end running of the system [end 15.3.12] D8.6: Facilitating Data sharing – SHRINE [end 15.3.12] 4.2. Project Management and Governance 4.2.1. The project will be managed using the PRINCE2 methodology in line with UoL project management standards with additional reporting on a six-monthly basis to align with JISC requirements. o o 6 4.2.2. The core Project Team will be coordinated by Dr Jonathan Tedds (PI) and work under the direction of Mary Visser (Director, ITS) and Dr Chris Rudge (Manager, Research Computing Services ITS). The technical project will be managed by a full-time Senior Project Manager in IT Services for UoL (David Carter) and will include key personnel from each partner and department involved as below. 4.2.3. Design and delivery of the solution will be undertaken by staff with relevant expertise as below (a total of approximately 10.6 FTE over 12 months). 4.2.4. Regular reviews will be undertaken of progress, actions, risks, issues, deliverables and plans with reports to the Project Board. The Team will meet at least fortnightly or as required. The membership of the technical team will flex in line with the demands of the project. Information on key staff that will support the requirements analyses and design phases is detailed in the table below. Name Dr Jonathan Tedds Project Role PI and Project Coordinator David Carter Project Manager Jeff Lusted Senior Java Programmer Dr Jon Wakelin Dr Chris Rudge Software Developer Research Computing Services Manager Database Architect Web Services Architect Research to Clinical Ontological mapping Liam Gretton Stuart Poulton Dr Tim Beck Dr Rob Free Clinical database architect Carl Nelson Maureen Collins Data Security specialist UHLT IT architect Manish Manager o o Experience >18 years experience in research; managed UK and EU FP6 work programmes to develop e-science research tools for astrophysics users at UoL and other European Space Agency funded universities. Currently Senior Research Liaison Manager with UoL IT Services. >20 years with a successful track record as an IT infrastructure Programme Manager in the commercial sector. Qualified in PRINCE2. Project managed the implementation of the new High Performance Computing Service (c. £2M CIF funded initiative) and Halogen JISC MRD project. Has spent the last year on the BRICCS project. 6 years on the UK escience AstroGrid project and JISC AGAST project. Prior to that he worked for IBM Global Services. He has been associated with database systems since the early 1980's. >5 years experience in software development as a researcher followed by roles in supporting researchers at the University of Bristol, now UoL. >10 years experience providing research computing infrastructure and support for astronomy researchers at Leicester and nationally and also wider support to researchers at the University of Leicester. Manager of the Research Computing Services team in IT Services >5 years experience of technical infrastructure design in complex technical environments. >10 years as a Web information and database architect and designer. Experience in supporting projects with complex datasets Postdoctoral Research Fellow (Genetics): >7 years experience in mapping of research to clinical ontologies/vocabularies. Use of phenotype (disease related) ontologies and controlled vocabularies in a research including Medical Subject Headings (MeSH) and the Human Phenotype Ontology (HPO). Use of NLM Unified Medical Language System (UMLS) including SNOMEDCT ontology used in BRICCS. Postdoctoral Research Fellow (Genetics): >5 years experience visualization/graphical tools for interrogating and integrating one or more data-sets; creating and modifying existing tools for advanced data mining. In clinical data field developed a tuberculosis clinical notifications system to integrate patient and specimen data from the Patient Master Index and UHLT databases. >20 years in IT with special responsibility for data security in UoL IT Services Programme manager for systems integration, data warehousing and business intelligence within the UHLT IM&T team. Working in collaboration with the BRU to supply data from the applications around the Trust in support of the BRICCS research project. Department Manager in the Department of Cardiovascular Sciences. 7 Maisuria Cardiovascul ar Sciences Based at Glenfield Hospital he will be responsible for the interface between academic and technical expertise on the side of both the UHL Trust and the University. Dave Morris Senior Developer 7 years experience developing the cloud-compute based infrastructure for automatic deployment and testing of UK e-science AstroGrid services; use of Amazon EC2, FlexiScale, SliceHost, RackSpace and ByteMark commercial cloud-compute services. Deployment and managing of virtual machines using the Linux KVM virtualization tools. 6 months working with the BRICCS project to develop automatic installation and deployment tools to deploy the BRICCS data services onto the VMware virtual machine infrastructure provided by ITS-RCS. 4.2.5. The Project Board will meet in line with key management decision points throughout the project and will be reviewers and signatories for all major deliverables starting with the Project Initiation Document. Name and positions Prof Nilesh Samani (Executive) British Heart Foundation Professor of Cardiology in the University and Honorary Consultant Cardiologist in the Trust and is the Director of the LCBRU Prof Anthony Brookes (Senior User) Professor of Bioinformatics and Genomics, Department of Genetics Prof Alison Goodall (Senior User) Professor, Department of Cardiovascular Sciences Mary Visser (Senior Supplier) Director of IT Services Prof Paul Burton (Senior User) Professor of Genetic Epidemiology Neil Beagrie (National Consultant) Director of consultancy at Charles Beagrie Ltd Prof Leon Ng (Senior User) Professor of Medicine and Therapeutics and Honorary Consultant Physician o o Remit and contribution Chair of Project Board Overall institutional direction and engagement Fellow of the Academy of Medical Sciences and amongst the first 100 NIHR Senior Investigators. Internationally recognised for his work on the genetics of coronary disease and hypertension. Bioinformatics research using anonymised clinical datasets Innovating and improving technologies for the experimental study of DNA variation in relation to cancer and other disorders Devising next-generation approaches towards web-based data management of complex information emerging from the global study of DNA variation in disease contexts. LCBRU Principal Investigator Knowledge and experience in cardiovascular research requirements and departmental direction and issues IT strategy, policy guidance Supplier of implementation and support services Internationally recognised for his work in statistical genetics; design and harmonization of large scale population-based biobanks and clinical bio-repositories. Science Coordinator of the FP6 PHOEBE project (Promoting Harmonization of Epidemiological Biobanks in Europe) Chief Scientific Officer and Chair of the Executive Steering Committee of P3G - the international organisation aimed at harmonizing population-based biobanks across the globe. Co-lead on the DataSHaPER project (Data Schema and Harmonization Platform for Epidemiological Research) Experienced senior consultant and an internationally recognised expert in digital curation Extensive experience with research data, cost/benefit analysis, business planning and sustainability. Leader in the field of novel biomarkers in cardiac disease Strong collaborations with industry in developing near-patient or laboratory assays based on these findings. Established one of the largest Coronary Care Unit databases 8 Name and positions Prof Iain Squire (Senior User) Professor of Cardiovascular Medicine & Honrary Consultant Physician Representative or nominee of JISC as the project funder Funding Body Member 4.3. Remit and contribution UK co-ordinator of a Europe-wide Cardiac Resynchronisation Registry, on behalf of the Heart Failure Association and Heart Rhythm Society of the European Society of Cardiology Editorial boards : British Journal of Clinical Pharmacology International Editorial Board, 2000-2004 Clinical Science Editorial Advisory Board August 2006-current Risk Analysis No Risk Probability Impact Staffing not in place at 1 low low project start Absence, illness or 2 loss of key staff during the project low Scope of project overambitious high 3 Lack of buy-in, engagement or 4 commitment from internal stakeholders 5 4.4. Technology-related failures low low Mitigation Key project directing/managing staff already in post both in UoL and UHLT. A ‘pool’ of analysts and technical resource exists within IT Services the workload of these could be reprioritised to support this initiative. low Team-based culture with collaborative practice to share learning and knowledge amongst team members. Strong Project Board involvement to provide realistic and pragmatic project guidance. medium Early refinement of work packages in consultation with stakeholders represented on Project Board. high Very high level commitment in UoL, UHLT, JISC Strategic importance of developing integrated approach recognised low Experienced in-house technical resource to help with design and implementation of technical solutions. Can exploit existing data management infrastructure within IT Services and UoL if external problems. The evaluation criteria for any new infrastructure components will be weighted to reflect the need for ‘well proven’ and ‘robust’ solutions IPR 4.4.1. With the exception of potentially sensitive commercial, budgetary and personnel information, the UoL offers a non-exclusive licence to JISC and its representatives to utilise, archive and disseminate any documentation produced as part of this project. This information will be made available in the public domain via the project website and via regular project reports to JISC. Technical developments will be licensed as open source where appropriate and will be made available to the JISC and the wider educational community. 5. Budget Apr 11 – Mar 12 Directly Incurred Staff UHLT Senior IT Architect (Collins) @ 1.0 FTE UHLT BRICCS Senior IT Consultant (Morris) o o 9 TOTAL £ @ 0.2 FTE Charles Beagrie Consultants Neil Beagrie @15 days + junior @ 20 days Postdoctoral Research Fellow (Beck) @ 0.5 FTE Postdoctoral Research Fellow (Free) @ 0.5 FTE Total Directly Incurred Staff (A) Non-Staff Travel and expenses Travel for Project Board members ( 1 external Board member) Travel for project staff to support programme activity Hardware/software Servers, storage, backup, maintenance and network connectivity (UoL) Servers, storage, backup, maintenance and network connectivity (UHLT) OBiBa OS software development Dissemination Online dissemination media set-up Conference dissemination (~10 staff to 2 conferences over life of project) Other Room & refreshments for Project meetings Consumables Total Directly Incurred Non-Staff (B) Directly Incurred Total (C) (A+B=C) Directly Allocated Staff Senior ITS Research Liaison Manager (Tedds) @ 1.0 FTE Senior Project Manager (Carter) @ 1.0 FTE ITS Research Computing Services (RCS) Team o o 10 Manager (Rudge) @ 0.1 FTE ITS RCS Software Architect (Wakelin) @ 1.0 FTE ITS RCS Database Architect (Gretton) @ 1.0 FTE ITS RCS Web Service Architect (Poulton) @ 1.0 FTE ITS RCS Senior Java Programmer (Lusted) @ 1.0 FTE UoL Cardiovascular IT Manager (Maisuria) @ 1.0 FTE ITS Senior Data Security Specialist (Nelson) @ 0.2 FTE Prof N. Samani, Clinical Professor Banded @ 0.2 FTE Prof A. Goodall, Professor @ 0.2 FTE Prof A. Brookes, @ 0.05 FTE Prof L. Ng, Clinical Professor @ 0.2 FTE Prof P. Burton, Clinical Professor @ 0.05 FTE Prof. I. Squire, Clinical Professor @ 0.2 FTE Mary Visser, Director ITS, @ 0.05 FTE Estates £25,991.96 £25,991.96 Other – total pooled Lab Techs £5,161.32 £5,161.32 Directly Allocated Total (D) £557,952 £557,952 Indirect Costs (E) £71,758 £71,758 Total Project Cost (C+D+E) £864,971 £864,971 Amount Requested from JISC: £816,096 £816,096 Institutional Contributions £48,875 £48,875 o o 11 Percentage Contributions over the life of the project No. FTEs used to calculate indirect and estates charges, and staff included A cumulative 1.95 FTE or 195% FTE has been used to calculate estates and indirect costs. JISC % Partners % Total 94.35% 5.65% 100% No FTEs Which Staff 1.95 FTE or 195% FTE All members of staff (directly incurred and allocated) are included in the costs. 5.1.1. To ensure a rapid start staffing will be allocated with immediate effect and backfilled if necessary. All key personnel are identified and already in post. 6. Engagement with the community, milestones and sustainability Engaging expert external consultancy from Charles Beagrie Ltd in developing business planning and sustainability we will work to the following key milestones: Timing Factors to evaluate Measures of success June 2011 Detailed project plan (1.1) VM Test facilities (2.2) Artifact repository (3.2) caTissue deployment mechanism (4.4) Exists Operational Exists Deployed and tested September 2011 Generic deployment infrastructure (3.3) caTissue API client (4.2) Data generation tools (5.4) Data warehouse application (7.3) UK customisations (7.1) Integration of caTissue / i2b2 (8.1) Provision of workshops (9.1) Exists Available for use Data available for export Deployed Complete Available Scheduled January 2012 Revised project plan (1.2) UK cstomisation of caTissue (4.3) Grid deployment of caTissue (4.6) Principles of Questionnaire Design (5.2) Data capture from clinical systems (6.3) Ontology pull cell for i2b2 (7.4) Clinical deployment guide (8.2) Clinical deployment tools (8.3) Provision of workshops (9.2 – 9.5) On schedule to revised plan Integrated into core code Grid available Documented Documented Accesses alternative sources Documented Underway Scheduled o o 12
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