Table of Contents Volume 83, Number 16, October 14, 2014 Neurology.org THE MOST WIDELY READ AND HIGHLY CITED PEER-REVIEWED NEUROLOGY JOURNAL IN FOCUS 1391 Spotlight on the October 14 Issue 1452 This Week’s Neurology® Podcast 1432 Neuropsychological features in childhood and juvenile multiple sclerosis: Five-year follow-up M.P. Amato, B. Goretti, A. Ghezzi, B. Hakiki, C. Niccolai, S. Lori, L. Moiola, M. Falautano, R.G. Viterbo, F. Patti, S. Cilia, C. Pozzilli, V. Bianchi, M. Roscio, V. Martinelli, G. Comi, E. Portaccio, and M. Trojano, on behalf of the MS Study Group of the Italian Neurological Society 1439 “Mirror EPC”: Epilepsia partialis continua shifting sides after rolandic resection in dysplasia M. Hemb, E. Paglioli, F. Dubeau, F. Andermann, A. Olivier, J.C. da Costa, W.A. Martins, M.L. Nunes, and A. Palmini 1444 Auras in generalized epilepsy P. Dugan, C. Carlson, J. Bluvstein, D.J. Chong, D. Friedman, and H.E. Kirsch, on behalf of the EPGP Investigators EDITORIALS 1392 Smoking and Parkinson disease: Where there is smoke there may not be ﬁre L.A. Hershey and J.S. Perlmutter 1394 Areas of persisting controversy in brain death J.L. Bernat and D. Larriviere ARTICLES 1396 Parkinson disease and smoking revisited: Ease of quitting is an early sign of the disease B. Ritz, P.-C. Lee, C.F. Lassen, and O.A. Arah Editorial, p. 1392 1403 Effects of deep brain stimulation on pain and other nonmotor symptoms in Parkinson disease R.G. Cury, R. Galhardoni, E.T. Fonoff, M.G. dos Santos Ghilardi, F. Fonoff, D. Arnaut, M.L. Myczkowski, M.A. Marcolin, E. Bor-Seng-Shu, E.R. Barbosa, M.J. Teixeira, and D. Ciampi de Andrade 1410 Relation of DASH- and Mediterranean-like dietary patterns to cognitive decline in older persons C.C. Tangney, H. Li, Y. Wang, L. Barnes, J.A. Schneider, D.A. Bennett, and M.C. Morris 1417 Depression in small-vessel disease relates to white matter ultrastructural damage, not disability R.L. Brookes, V. Herbert, A.J. Lawrence, R.G. Morris, and H.S. Markus GLOBAL PERSPECTIVES 1450 SPECIAL ARTICLE 1453 Cerebrovascular reactivity predicts stroke in high-grade carotid artery disease M. Reinhard, G. Schwarzer, M. Briel, C. Altamura, P. Palazzo, A. King, N.M. Bornstein, N. Petersen, E. Motschall, A. Hetzel, R.S. Marshall, C.J.M. Klijn, M. Silvestrini, H.S. Markus, and F. Vernieri Evidence-based guideline summary: Diagnosis and treatment of limb-girdle and distal dystrophies: Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Issues Review Panel of the American Association of Neuromuscular & Electrodiagnostic Medicine P. Narayanaswami, M. Weiss, D. Selcen, W. David, E. Raynor, G. Carter, M. Wicklund, R.J. Barohn, E. Ensrud, R.C. Griggs, G. Gronseth, and A.A. Amato CONTEMPORARY ISSUES 1464 1424 Neurology mission(s) impossible A.L. Berkowitz Why brain death is considered death and why there should be no confusion C.M. Burkle, R.R. Sharp, and E.F. Wijdicks Editorial, p. 1394 CROSSROADS 1470 Targeting the low-hanging fruit of neurodegeneration A.R. Mason, A. Ziemann, and S. Finkbeiner CONTINUED Table of Contents continued 1473 RESIDENT & FELLOW SECTION Nourish the roots while picking the fruit R.L. Albin e149 Pearls & Oy-sters: Cough headache secondary to Chiari malformation type I J.E. Bates and E.F. Augustine e152 Clinical Reasoning: A 50-year-old woman with deep stabbing ear pain J.M. DeLange, I. Garza, and C.E. Robertson e158 Teaching NeuroImages: Spherules in spine: Vertebral coccidioidomycosis D. Dubey, R.N. Narayan, A. Motiwala, and P. Gupta CLINICAL/SCIENTIFIC NOTES 1476 1478 Identical twins with the C9orf72 repeat expansion are discordant for ALS Z. Xi, Y. Yunusova, M. van Blitterswijk, S. Dib, M. Ghani, D. Moreno, C. Sato, Y. Liang, A. Singleton, J. Robertson, R. Rademakers, L. Zinman, and E. Rogaeva Dramatic response of a BRAF V600E-mutated primary CNS histiocytic sarcoma to vemurafenib A. Idbaih, K. Mokhtari, J.-F. Emile, D. Galanaud, H. Belaid, S. de Bernard, N. Benameur, V.-C. Barlog, D. Psimaras, J. Donadieu, C. Carpentier, N. Martin-Duverneuil, J. Haroche, L. Feuvret, N. Zahr, J.-Y. Delattre, and K. Hoang-Xuan WRITECLICK EDITOR’S CHOICE ® 1484 Tournay’s description of anisocoria on lateral gaze: Reaction, myth, or phenomenon? J.A. Fraser; Author Response: M.P. Robert, G.T. Plant 1484 Summary of evidence-based guideline: Complementary and alternative medicine in multiple sclerosis: Report of the Guideline Development Subcommittee of the American Academy of Neurology S. Wright; Author Response: V. Yadav, C. Bever, Jr, J. Bowen, A. Bowling, B. Weinstock-Guttman, REFLECTIONS: NEUROLOGY AND THE HUMANITIES 1481 The unwanted guest N. Pemmaraju NEUROIMAGES 1483 MRI and encephalography in fatal eastern equine encephalitis M.-A. Babi, T. Raleigh, R.E. Shapiro, J. McSherry, and A. Applebee Podcast at Neurology.org CME Video M. Cameron, D. Bourdette, G.S. Gronseth, P. Narayanaswami DEPARTMENT Patient Page tinyurl.com/neurologyfan In the Next Issue of Neurology® LOE classiﬁcation LOE recommendation twitter.com/GreenJournal Cover image: Ictal SPECT before (top) and after (bottom) right rolandic resection for left side epilepsia partialis continua (EPC). Note that focal hyperperfusion shifted sides in connection with unexpected contralateral re-emergence of EPC. See page 1439. Look for Publish Ahead of Print articles and editorials under the Ahead of Print tab at Neurology.org