JAC The Journal of Antimicrobial Chemotherapy Volume 69 Number 10 October 2014 Contents Review Pharmacokinetics and pharmacodynamics of boosted once-daily darunavir Thomas N. Kakuda, Anne Brochot, Frank L. Tomaka, Tony Vangeneugden, Tom Van De Casteele and Richard M. W. Hoetelmans Systematic reviews Tigecycline in treatment of multidrug-resistant Gram-negative bacillus urinary tract infections: a systematic review K. Brust, A. Evans and R. Plemmons Adverse effects associated with ethanol catheter lock solutions: a systematic review Leonard A. Mermel and Neha Alang Original research Characterization of pFOX-7a, a conjugative IncL/M plasmid encoding the FOX-7 AmpC-type b-lactamase, involved in a large outbreak in a neonatal intensive care unit Vincenzo Di Pilato, Fabio Arena, Tommaso Giani, Viola Conte, Stefania Cresti and Gian Maria Rossolini A conjugative plasmid carrying the carbapenem resistance gene blaOXA-23 in AbaR4 in an extensively resistant GC1 Acinetobacter baumannii isolate Mohammad Hamidian, Johanna J. Kenyon, Kathryn E. Holt, Derek Pickard and Ruth M. Hall Characterization of plasmids carrying the blaOXA-24/40 carbapenemase gene and the genes encoding the AbkA/AbkB proteins of a toxin/antitoxin system Noraida Mosqueda, Eva Gato, Ignasi Roca, Marı´a Lo´pez, Carlos Ruı´z de Alegrı´a, Felipe Ferna´ndez Cuenca, Luis Martı´nez-Martı´nez, Jero´nimo Pacho´n, Jose´ Miguel Cisneros, Jesu´s Rodrı´guez-Ban˜o, A´lvaro Pascual, Jordi Vila, Germa´n Bou and Marı´a Toma´s on behalf of GEIH-GEMARA (SEIMC) and REIPI 2591 2606 2611 2620 2625 2629 Deficiency of the ferrous iron transporter FeoAB is linked with metronidazole resistance in Bacteroides fragilis 2634 Yaligara Veeranagouda, Fasahath Husain, Renata Boente, Jane Moore, C. Jeffrey Smith, Edson R. Rocha, Sheila Patrick and Hannah M. Wexler Presence of disinfectant resistance genes in Escherichia coli isolated from retail meats in the USA Likou Zou, Jianghong Meng, Patrick F. McDermott, Fei Wang, Qianru Yang, Guojie Cao, Maria Hoffmann and Shaohua Zhao 2644 Characterization of extended-spectrum b-lactamase (ESBL)-producing Escherichia coli obtained from Danish pigs, pig farmers and their families from farms with high or no consumption of third- or fourth-generation cephalosporins Anette M. Hammerum, Jesper Larsen, Vibe D. Andersen, Camilla H. Lester, Timmy S. Skovgaard Skytte, Frank Hansen, Stefan S. Olsen, Hanne Mordhorst, Robert L. Skov, Frank M. Aarestrup and Yvonne Agersø 2650 Nucleotide sequences of 16 transmissible plasmids identified in nine multidrug-resistant Escherichia coli isolates expressing an ESBL phenotype isolated from food-producing animals and healthy humans Juan Wang, Roger Stephan, Karen Power, Qiongqiong Yan, Herbert Ha¨chler and Se´amus Fanning 2658 Extended-spectrum and AmpC b-lactamase-producing Escherichia coli in broilers and people living and/or working on broiler farms: prevalence, risk factors and molecular characteristics P. M. C. Huijbers, E. A. M. Graat, A. P. J. Haenen, M. G. van Santen, A. van Essen-Zandbergen, D. J. Mevius, E. van Duijkeren and A. H. A. M. van Hoek 2669 Clonal spread of highly successful ST15-CTX-M-15 Klebsiella pneumoniae in companion animals and horses 2676 Christa Ewers, Ivonne Stamm, Yvonne Pfeifer, Lothar H. Wieler, Peter A. Kopp, K. Schønning, Ellen Prenger-Berninghoff, Sandra Scheufen, Inka Stolle, Sebastian Gu¨nther and Astrid Bethe Molecular basis of non-mutational derepression of ramA in Klebsiella pneumoniae Shyamasree De Majumdar, Jing Yu, James Spencer, Irina G. Tikhonova and Thamarai Schneiders 2681 Mechanisms of reduced susceptibility and genotypic prediction of antibiotic resistance in Prevotella isolated from cystic fibrosis (CF) and non-CF patients 2690 Laura J. Sherrard, Bettina Schaible, Kathryn A. Graham, Stef J. McGrath, Leanne McIlreavey, Joseph Hatch, Matthew C. Wolfgang, Marianne S. Muhlebach, Deirdre F. Gilpin, Thamarai Schneiders, J. Stuart Elborn and Michael M. Tunney Carbapenemase and virulence factors of Enterobacteriaceae in North Lebanon between 2008 and 2012: evolution via endemic spread of OXA-48 R. Beyrouthy, F. Robin, F. Dabboussi, H. Mallat, M. Hamze´ and R. Bonnet Incidence rates of carbapenemase-producing Enterobacteriaceae clinical isolates in France: a prospective nationwide study in 2011 – 12 Je´roˆme Robert, Alix Pantel, Audrey Me´rens, Jean-Philippe Lavigne and Marie-He´le`ne Nicolas-Chanoine on behalf of ONERBA’s Carbapenem Resistance Study Group Antimicrobial activity of ceftolozane/tazobactam tested against Pseudomonas aeruginosa and Enterobacteriaceae with various resistance patterns isolated in European hospitals (2011 – 12) Helio S. Sader, David J. Farrell, Mariana Castanheira, Robert K. Flamm and Ronald N. Jones A novel benzonitrile analogue inhibits rhinovirus replication Ce´line Lacroix, Jordi Querol-Audı´, Manon Roche, David Franco, Mathy Froeyen, Pablo Guerra, Thierry Terme, Patrice Vanelle, Nu´ria Verdaguer, Johan Neyts and Pieter Leyssen 2699 2706 2713 2723 Addition of E138K to R263K in HIV integrase increases resistance to dolutegravir, but fails to restore activity of the HIV integrase enzyme and viral replication capacity 2733 Thibault Mesple`de, Nathan Osman, Melissa Wares, Peter K. Quashie, Said Hassounah, Kaitlin Anstett, Yingshan Han, Diane N. Singhroy and Mark A. Wainberg Early selection of resistance-associated mutations in HIV-1 RT C-terminal domains across different subtypes: role of the genetic barrier to resistance 2741 Cla´udia P. Muniz, Marcelo A. Soares and Andre´ F. Santos Broad anti-HIV activity of the Oscillatoria agardhii agglutinin homologue lectin family Geoffrey Fe´rir, Dana Huskens, Sam Noppen, Leonardus M. I. Koharudin, Angela M. Gronenborn and Dominique Schols 2746 The M-T hook structure increases the potency of HIV-1 fusion inhibitor sifuvirtide and overcomes drug resistance 2759 Huihui Chong, Xue Yao, Zonglin Qiu, Jianping Sun, Yuanyuan Qiao, Meng Zhang, Meitian Wang, Sheng Cui and Yuxian He Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral Leen Delang, Nidya Segura Guerrero, Ali Tas, Gilles Que´rat, Boris Pastorino, Mathy Froeyen, Kai Dallmeier, Dirk Jochmans, Piet Herdewijn, Felio Bello, Eric J. Snijder, Xavier de Lamballerie, Byron Martina, Johan Neyts, Martijn J. van Hemert and Pieter Leyssen In vivo imaging of disseminated murine Candida albicans infection reveals unexpected host sites of fungal persistence during antifungal therapy Ilse D. Jacobsen, Anja Lu¨ttich, Oliver Kurzai, Bernhard Hube and Matthias Brock Population pharmacokinetics and dosing simulations of cefuroxime in critically ill patients: non-standard dosing approaches are required to achieve therapeutic exposures Mieke Carlier, Michae¨l Noe¨, Jason A. Roberts, Veronique Stove, Alain G. Verstraete, Jeffrey Lipman and Jan J. De Waele 2770 2785 2797 Switching from tenofovir/emtricitabine and nevirapine to a tenofovir/emtricitabine/rilpivirine single-tablet regimen in virologically suppressed, HIV-1-infected subjects C. Allavena, E. Dailly, V. Reliquet, B. Bonnet, S. Pineau, E. Andre´-Garnier, D. Boutoille, R. Bouquie´, A. Raveleau, S. Bouchez, E. Billaud and F. Raffi Impact of raltegravir on HIV-1 RNA and DNA forms following initiation of antiretroviral therapy in treatment-naive patients Christoph Stephan, Hanna-Mari Baldauf, Joanne Barry, Frank A. Giordano, Cynthia C. Bartholomae, Annette Haberl, Markus Bickel, Manfred Schmidt, Stephanie Laufs, Lars Kaderali and Oliver T. Keppler 2804 2809 Virological outcome at week 48 of three recommended first-line regimens using ultrasensitive viral load and plasma drug assay 2819 Charlotte Charpentier, Marion Choquet, Ve´ronique Joly, Patrick Yeni, Benoit Visseaux, Marion Caseris, Franc¸oise Brun-Ve´zinet, Yazdan Yazdanpanah, Gilles Peytavin, Diane Descamps and Roland Landman Factors associated with mortality among persistently viraemic triple-antiretroviral-class-experienced patients receiving antiretroviral therapy in the HIV Outpatient Study (HOPS) 2826 Frank J. Palella Jr, Carl Armon, Kate Buchacz, Joan S. Chmiel, Richard M. Novak, Richard T. D’Aquila and John T. Brooks on behalf of the HOPS Investigators Clinical cure rates in subjects treated with azithromycin for community-acquired respiratory tract infections caused by azithromycin-susceptible or azithromycin-resistant Streptococcus pneumoniae: analysis of Phase 3 clinical trial data 2835 George G. Zhanel, Kevin D. Wolter, Cristina Calciu, Patricia Hogan, Donald E. Low, Karl Weiss and James A. Karlowsky Clinical significance of 2 h plasma concentrations of first-line anti-tuberculosis drugs: a prospective observational study Julie B. Prahl, Isik S. Johansen, Arieh S. Cohen, Niels Frimodt-Møller and A˚se B. Andersen 2841 The efficacy of non-carbapenem antibiotics for the treatment of community-onset acute pyelonephritis due to extended-spectrum b-lactamase-producing Escherichia coli 2848 Sun Hee Park, Su-Mi Choi, Yoon Kyung Chang, Dong-Gun Lee, Sung-Yeon Cho, Hyo-Jin Lee, Jung-Hyun Choi and Jin-Hong Yoo Impact of a computerized decision support system on compliance with guidelines on antibiotics prescribed for urinary tract infections in emergency departments: a multicentre prospective before-and-after controlled interventional study 2857 Elisa Demonchy, Jean-Charles Dufour, Jean Gaudart, Emmanuel Cervetti, Pierre Michelet, Nicolas Poussard, Jacques Levraut and Ce´line Pulcini Research letters Detection of mecC methicillin-resistant Staphylococcus aureus with a semi-selective enrichment broth C. Ekenberg, K. Boye, K. Schønning, H. Westh and G. Lisby 2864 Resistance to third-generation cephalosporins in Acinetobacter baumannii due to horizontal transfer of a chromosomal segment containing ISAba1-ampC Mohammad Hamidian and Ruth M. Hall 2865 Identification of fluoroquinolone-resistant extended-spectrum b-lactamase (CTX-M-8)-producing Escherichia coli ST224, ST2179 and ST2308 in buffalo (Bubalus bubalis) 2866 Juliana Aizawa, Natalie Neuwirt, Leandro Barbato, Patrı´cia R. Neves, Lucianne Leigue, Joa˜o Padilha, Antonio F. Pestana de Castro, Lilian Gregory and Nilton Lincopan Isolation of ciprofloxacin-resistant Legionella pneumophila in a patient with severe pneumonia Jacob P. Bruin, Tetyana Koshkolda, Ed P. F. IJzerman, Christian Lu¨ck, Bram M. W. Diederen, Jeroen W. Den Boer and Johan W. Mouton 2869 Molecular surveillance and prevalence of carbapenem-resistant Enterobacteriaceae in Northern Taiwan Wen-Shyang Hsieh, Nai-Yu Wang, Jou-An Feng, Li-Chuan Weng and Hsueh-Hsia Wu 2871 In vitro activity of mecillinam against Enterobacteriaceae with NDM-1 carbapenemase Emma C. L. Marrs, Kathryn M. Day and John D. Perry 2873 Favourable outcome in the treatment of carbapenem-resistant Enterobacteriaceae urinary tract infection with high-dose tigecycline K. Brust, A. Evans and R. Plemmons Measurement units for antibiotic consumption in outpatients Milan Cˇizˇman 2875 2877 An emerging understanding of the Janus face of the human microbiome: enhancement versus impairment of cancer therapy 2878 Johan Vande Voorde, Jan Balzarini and Sandra Liekens Letter to the Editor Comment on: Antiretroviral treatment French guidelines 2013: economics influencing science P. Morlat and B. Hoen on behalf of the 2013 French HIV Expert Group 2881