Solid State Medical Imaging: X-Ray and Endoscopy SAMPLE The Medical Image Sensors market is expected to double over the next five years. M&A are increasing. Discover how Medical Imaging is being reshaped! Overview of the technical & economic requirements for Medical Imaging applications October 2014 Le Quartz - 75 cours Emile Zola - 69100 LYON-Villeurbanne Tel: +33 472 83 01 80 - Fax: +33 472 83 01 83 Web: www.yole.fr Table of content 1) 2) 3) 4) Executive Summary ………………...........................p.4 Introduction, Definitions & Methodology …….…p.16 What’s Happened in the Last Two Years?...........p.39 Medical Image Sensor technologies overview….p.13 – – – – – 5) CCD image sensors CMOS image sensors Amorphous silicon flat panels Technologies comparison Specificity of X-ray imaging 6) Market segmentation ....................................p.64 – – 7) Market drivers by segment Technology positioning Product categories description .....................p.72 – Focus on endoscopy applications o o Medical Image Sensors Market Overview ...…….p.35 – Global imaging market o – Endoscopy market o o – Forecasts in revenue /volume split by product category Forecasts in revenue and in volume split by product category a-Si flat panel sensors market o © 2014 • o CMOS medical image sensors market o – Split by technology (CCD, CMOS and a-Si) Forecasts in revenue/volume/wafer shipments CCD medical image sensors market o – o Split by technology (CCD & CMOS) Forecasts in revenue/volume/wafer shipments X-ray imaging market o o – Forecasts in revenue/volume 2 - Forecasts in revenue and in volume split by product category Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved. Rigid endoscopes Market revenue/volume Market drivers Players Technologies Flexible endoscopes Market revenue/volume Market drivers Players Technologies Camera pills Market revenue/volume Market drivers Players Technologies Disposable endoscopes Market revenue/volume Market drivers Players Technologies Table of content – Focus on X-ray imaging o o Dental X-ray imaging Market revenue/volume Market drivers Players Technologies Medical X-ray imaging Market revenue/volume Market drivers Players Technologies 10) Medical Image Sensors Challenges….p.287 11) Summary and Conclusions………………p.299 8) Medical Image Sensors Supply Chain Analysis..p.267 – – – – – – Rigid endoscopes Flexible endoscopes Camera pills Disposable endoscopes X-ray intraoral detectors X-ray flat panel detectors 9) Medical Image Sensors Value Chain Analysis...p.279 – – – – – – – © 2014 • Disposable endoscope value chain Flexible endoscope value chain Rigid endoscope value chain CMOS camera pill value chain A Si flat static panel detector value chain A Si flat dynamic panel detector value chain CMOS panel intra oral detector value chain 3 Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved. Some Companies Cited in the Report AGFA, Alcon, Austria Microsystems, CMOSIS (Awaiba), BioVision Technologies LLC , Caeleste, CapsoVision Inc., Carestream Health, Circon, Cyber Medical, Dongbu Hitek, e2v, EndoOptiks, Escalon, FiberTech, Fujifilm, Fujinon, General Electrics, GI View, Giotto, Given Imaging, GMM, Hamamatsu, Hitachi, Hologic, Hoya Life Sciences, Imix, IntroMedic, Intuitive Surgical ,Invendo Medical, ISDI, Italray, Jinshan Group, Karl Storz, Konica Minolta, Medigus, Micro-Imaging Solutions, Olympus, ON semiconductor (Cypress), OSAT, VT & Aptina, Palodex, Panasonic, Perkin Elmer (Dexela), Philips, Primax, Pyxalis, RF Systems labs, Richard Wolf, Samsung, Shimadzu, Siemens, Sony, STMicro, Stryker, Swissray, Teledyne DALSA, Toshiba, TowerJazz, Trixell, True sense imaging, TSMC, Varian, Vatech Human ray, Villa, VIM’S, X-Fab, Ziehm Imaging… © 2014 • 4 Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved. Medical Image Sensors Scope of the report Indirect Imaging / Software Dependant Direct Imaging / Hardware Dependant Standalone Application Microscopy Camera pills Disposable MRI X-Ray imagers for intra-oral imaging X-Ray imagers for 3D & large X-Ray imagers area imaging for 2D extraoral imaging Microscopes Optical Imaging • • • X-Ray based methods Ultrasound Nuclear Imaging Medicine Disposable endoscopes Flexible Rigid endoscopes endoscopes Re-usable Integrated into a large system Endoscopy Doppler ultrasound CT MRI syste m PET Scan X-ray Imaging This report will focus exclusively on direct Imaging applications. Microscopy is excluded from that report because is hardly ever used in vivo, primarily it is used in vitro. Indirect imaging applications will not be developed in this report as their evolution rather relies on software processing optimization. © 2014 • 5 Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved. Image Sensor Technologies by Market The table below links applicative markets and Medical Image Sensor (MIS) technologies: Endoscopy Application Camera pills market CCD MIS CMOS MIS X X Disposable endoscopes market X Flexible endoscopes market X X Rigid endoscopes market X X X-Ray Imaging Application intra-oral imaging market © 2014 • 6 A-Si MIS X X-ray 3D CBCT extra-oral imaging X 2D extra-oral market X 3D & large area market X X X X X Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved. Value Chain Analysis Technology penetration per markets and market shares are provided. © 2014 • 7 Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved. Market Forecast for equipment / sensors In value / volume / wafers shipments Instruments Markets… Sensors Markets… …splited by Medical Image Sensors technologies © 2014 • 8 Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved. Value Chain Analysis Detailed Value Chains have been added © 2014 • 9 Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved. Detailed Supply Chain Updated supply chain are available for each product category © 2014 • 10 Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved. Supply Chain evolution is described Our analysis on the supply chain evolution and the potential next targets are presented © 2014 • 11 Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved. Technology Trends X-Ray Imaging Technologies Overview • 1. CCD Image Intensified Camera 2. 3. +• -• X-Ray Three main components : Scintillator to convert x-ray into visible light Fiber Optic Taper for mignification CCD sensor for light to electron conversion Scintillator Fiber Optic Taper High resolution Buky, low field of view CCD sensor ADC • Two components: 1. Scintillator to convert x-ray into visible light 2. a-Si matrix array: passive pixels (photodiodes convert light into electrons + one TFT switch per pixel) a-Si FPD +• -• • Very large panel, simple, economical Low resolution, image lag, slow Two components: 1. CMOS FPD © 2014 • 12 Scintillator for x-ray to visible light conversion 2. CMOS image sensor: active pixel (photodiodes convert light into electrons + several transistors per pixel convert charges to voltage, on-pixel ADC & amplifier) •+ High speed/resolution •- Limited size needs sensor tiling, expensive Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved. Processing X-Ray Scintillator a-Si array X-Ray Scintillator CMOS image sensor About The Author Benjamin ROUSSEL He is leading the MedTech activity (microfluidic and medical technologies) at Yole Développement. He holds a pharmacy diploma from the University Claude Bernard Lyon, complemented by a master degree in Technology and Innovation Management from EM Lyon Business School. Contact: [email protected] © 2014 • 13 Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved.
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