SATURDAY, October 25, 2014 - 8:00 AM - 9:30 AM PLATFORM SESSIONS – Sat - 1 Track: Tissue Engineering, Cardiovascular Engineering - OP-Sat-1-1 - Room 001A Cardiac Muscle and Valve Tissue Engineering Chairs: Nenad Bursac, Song Li 8:00AM Tubular Heart Valves by Suturing Decellularized Engineered Tissue Tubes 1 1 1 1 J. Reimer , Z. Syedain , B. Haynie , and R. Tranquillo 1 University of Minnesota, Minneapolis, MN 8:15AM Electrically Stimulated Heart Microbundles as a 3D Model of Neonatal to Adult Cardiac Tissue Maturation 1 1 C. Jackman and N. Bursac 1 Duke University, Durham, NC 8:30AM Fibrous Tissue Scaffolds: Relationships between Geometric Structure and Mechanical Behavior 1 1 1 J. Carleton , G. Rodin , and M. Sacks 1 University of Texas at Austin, Austin, TX 8:45AM Three-Dimensional Artificial Heart Muscle to Supplement the Framework of a Bioartificial Heart 1 1 1 1 1 M. Hogan , M. Mohamed , Z-W. Tao , L. Gutierriez , and R. Birla 1 University of Houston, Houston, TX 9:00AM Tuning Material Properties of Cardiac Extracellular Matrix for Cardiac Tissue Engineering 1 2 2 2 1 M. Jeffords , J. Wu , Q. Ding , Y. Hong , and G. Zhang 1 2 The University of Akron, Akron, OH, University of Texas at Arlington, Arlington, TX 9:15AM Native Fiber Structure in Decellularized Myocardium Promotes Cardiac Cell Alignment and Maturation 1 1 1 1 1 J. Schwan , A. Kwaczala , T. Ryan , A. Lebid , and S. Campbell 1 Yale University, New Haven, CT Track: Biomaterials, Nano to Micro Technologies - OP-Sat-1-2 - Room 001B Micro and Nanostructured Materials Chairs: Scott Verbridge, Tzahi Cohen-Karni 8:00AM Tunable Microtopography Reduces Myofibroblast Activation and Cutaneous Fibrosis 1 1 1 J. Allen , J. Ryu , and T. Desai 1 University of California, San Francisco, San Francisco, CA 8:15AM Heat-Resistant RNA Biomaterials to Construct Nanoparticles with Controllable Size, Shape, and Stoichiometry for Biomedical Applications 1 1 1 E. Khisamutdinov , D. Jasinski , and P. Guo 1 Nanobiotechnology Center, Markey Cancer Center, and Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 8:30AM 2D Nanosheets for Osteogenic Differentiation of Human Mesenchymal Stem Cells 1 1 1 J. Xavier , P. Desai , and A. Gaharwar 1 Texas A&M University, College Station, TX 8:45AM Antigen-Independent Targeting of Cancer Cells on Polylysine/Fatty Acid Complexes 1 1 1 1 C. Castellanos , J. Li , M. Mitchell , and M. King 1 Cornell, Ithaca, NY BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 1 of 34 9:00AM Heparin Hydrogel Microdroplets for Cultivation of Embryonic Stem Cells 1 1 1 1 1 1 C. Siltanen , E. Foster , J. You , A. Haque , D-S. Shin , and A. Revzin 1 UC Davis, Davis, CA 9:15AM Biocompatible Sub-100 nm Patterning TiO2 for the Regulation of Endothelial and Smooth Muscle Cell Functions 1 1 1 2 2 1 1 M. Rizwan , S. Lim , S. Goh , J. Law , M. Saifullah , G. Ho , and E. Yim 1 2 National University of Singapore, Singapore, Singapore, Institute of Materials Research and Engineering, Singapore, Singapore Track: Cardiovascular Engineering - OP-Sat-1-3 - Room 006A Microcirculation Chairs: Taby Ahsan, Steven George 8:00AM Monocytes are Recruited From Post-Capillary Venules During the Early Phases of Arteriogenesis 1 1 1 1 1 A. Bruce , M. Kelly-Goss , J. Meisner , R. Price , and S. Peirce 1 Univ. of Virginia, Charlottesville, VA 8:15AM The Role Of Cathepsin B In The Control Of Neutrophil Pseudopod Activity Under Flow 1 1 M. Akenhead and H. Shin 1 University of Kentucky, Lexington, KY 8:30AM Flow Characteristics of Sickle Cell Blood in Hypoxic Conditions 1 1 2,3 1 X. Lu , C. Jonas , J. Higgins , and D. Wood 1 2 3 University of Minnesota, Minneapolis, MN, Harvard Medical School, Boston, MA, Massachusetts General Hospital, Boston, MA 8:45AM Vein-On-a-Chip: Functional Assessment and Activation of Intact Mouse Mesenteric Vein 1 1 1 Z. Abdi Dezfooli , S-S. Bolz , and A. Günther 1 University of Toronto, Toronto, ON, Canada 9:00AM Exogenous Nitric Oxide Supplementation To Enhance The Outcome Of Fluid Resuscitation From Hemorrhagic Shock 1 1 2 J. Crump , J. Briceno , and P. Cabrales 1 2 Universidad de Los Andes, Bogota D.C., Colombia, University of California, San Diego, La Jolla, CA 9:15AM Platelet GpIbα Binding to Von Willebrand Factor (VWF) under Hydrodynamic Shear: Relative Contributions of The D’D3-domain, A1-domain Flanking Peptide and O-linked Glycosylation 1 1 1 1 1 C. Zhang , A. Kelkar , S. Madabhushi , K. Dayananda , and S. Neelamegham 1 SUNY at Buffalo, Buffalo, NY Track: Biomechanics, Cardiovascular Engineering - OP-Sat-1-4 - Room 006B Cardiovascular Biomechanics I Chairs: Hanjoong Jo, Danial Shahmirzadi 8:00AM Biomechanical Characterizations Of Scar ECM During The Acute To Chronic Stages Of Myocardial Infarction 1 1 1 2 1 1 1 3 2 1 B. Brazile , J. Butler , S. Patnaik , Y. Xu , A. Claude , R. Prabhu , L. Williams , G. Zhang , J. Guan , and J. Liao 1 2 3 Mississippi State University, Mississippi State, MS, Ohio State University, Columbus, OH, University of Akron, Akron, OH 8:15AM Bending and Twisting the Embryonic Heart Tube: A Noval Computational Model 1 2 3 1 Y. Shi , J. Yao , R. Perucchio , and L. Taber 1 2 3 Washington University, St. Louis, MO, Dassault Systemes Simulia Corp., Providence, RI, University of Rochester, Rochester, NY BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 2 of 34 8:30AM Quantitative Histomorphological Analysis of Right Ventricular Myocardium Under Chronic Pressure Overload 1 1 1 1 2 1 S. M. Siegel , U. A. Dar , M. Rahman , M. R. Hill , M. A. Simon , and M. S. Sacks 1 2 The University of Texas at Austin, Austin, TX, The University of Pittsburgh, Pittsburgh, PA 8:45AM Exogenous Relaxin Treatment Reverses Left Ventricular Fibrosis and Improves Diastolic Function in a Rate Model 1 1,2 1 J. Haney , D. Schwartzman , and S. Shroff 1 2 University of Pittsburgh, Pittsburgh, PA, University of Pittsburgh Medical Center, Pittsburgh, PA 9:00AM Time-Evolving Growth and Remodeling Response of Right Ventricular Myocardium to Pressure Overload 1 2 1 M. Hill , M. Simon , and M. Sacks 1 2 University of Texas at Austin, Austin, TX, University of Pittsburgh, Pittsburgh, PA 9:15AM Probing Local Nonlinear Mechanics with Whole-Tissue Experiments 1 1 C. Witzenburg and V. Barocas 1 University of Minnesota, Minneapolis, MN Track: Cellular and Molecular Bioengineering - OP-Sat-1-5 - Room 006C Cell and Molecular Immunoengineering Chairs: Lance Kam, Chris Love 8:00AM Lipopolysaccharide (LPS) Induces the Interactions of Breast Cancer and Endothelial Cells via Activated Monocytes 1 1 C. Chen and D. Khismatullin 1 Tulane University, New Orleans, LA 8:15AM T-Pharmacytes for the Targeted Eradication of Latent HIV Reservoirs 1 1 1 1 1 1,2 1,2 B. Jones , S. Mueller , R. O'Connor , V. Vrbanac , A. Tager , B. Walker , and D. Irvine 1 2 Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, Howard Hughes Medical Institute, Chevy Chase, MD 8:30AM TLR3 Stimulation Enhances The Immune Stimulatory Properties of Exosome-based Vaccines 1 1 1 1 M. Damo , E. Simeoni , D. Wilson , and J. Hubbell 1 Swiss Federal Institute of Technology, Lausanne, Switzerland 8:45AM Development of a Tissue-Engineered Lymph Node to Study Stromal Immunomodulatory Functions In Vitro 1 1 C. Buchanan and M. Swartz 1 Ecole Polytechnique Federal de Lausanne, Lausanne, Switzerland 9:00AM Molecular-level Deconvolution of the Human Serum Antibody Repertoire Elicited by Vaccination 1 1 1 1 1 1 2 1 1 1 J. Lavinder , G. Ippolito , Y. Wine , D. Boutz , J. Blazeck , A. Horton , C. Giesecke , K. Hoi , B. Tan , E. Murrin , M. 1 1 2 1 1 Wirth , A. Ellington , T. Dörner , E. Marcotte , and G. Georgiou 1 2 University of Texas at Austin, Austin, TX, Charite Universitätsmedizin Berlin, Berlin, Germany 9:15AM Dysregulated Sphingolipid Metabolism In Sickled Erythrocytes & Inflammatory Microparticle Generation 1 1 1 1 1 1 A. Awojoodu , P. Keegan , A. Lane , Y. Zhang , M. Platt , and E. Botchwey 1 Georgia Institute of Technology, Atlanta, GA Track: Cardiovascular Engineering, Tissue Engineering - OP-Sat-1-6 - Room 006D Cardiac Regeneration Chairs: Milica Radisic, Lauren Black III 8:00AM Designing an Elastic Scaffold with Shape-Memory for Functional Tissue Delivery 1 1 1 1 M. Montgomery , B. Zhang , L. Reis , and M. Radisic 1 University of Toronto, Toronto, ON, Canada BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 3 of 34 8:15AM Generation of Functional Human Myocardium from Native Human Heart Matrix and Human iPS-derived Cardiomyocytes 1 1 1 1 J. Guyette , J. Charest , P. Moser , and H. Ott 1 Harvard Medical School, Boston, MA 8:30AM Engineering Mature Cardiac Tissue In Vitro: Biomechanical and Biochemical Stimulation of Physiological Hypertrophy. 1 2 2 1 C. Rupert , M. Regnier , C. Murry , and K. Coulombe 1 2 Brown University, Providence, RI, University of Washington, Seattle, WA 8:45AM In Vitro Recruitment of Macrophages by Human Embryonic Stem Cell-Derived Cardiomyocytes 1 1 1 I. Pallotta , E. Wrona , and D. Freytes 1 The New York Stem Cell Foundation Research Institute, New York, NY 9:00AM Cardiac Progenitor Cell Exosomes to Treat the Heart 1 2 3 3 2 4 S. Ghosh- Choudhary , W. Gray , K. Kanter , B. Kogon , M. Platt , and M. Davis 1 2 Georgia Institute of Technology, Atlanta, GA, Georgia Insititute of Technology and Emory University, Atlanta, GA, 3 4 Children's Healthcare of Atlanta, Atlanta, GA, Georgia Insititute of Technology and Emory University and Children's Healthcare of Atlanta, Atlanta, GA 9:15AM Hepatic Cell-Mediated Delivery of Trefoil Factor 3 to Ischemic Myocardium - A Trans-system Mechanism Against Cardiomyocyte Calcification 1 1 1 S. Liu , B. Zhang , and Y. Wu 1 Northwestern University, Evanston, IL Track: Stem Cell Engineering, Biomechanics - OP-Sat-1-7 - Room 007A Mechanobiology of Stem Cells Chairs: Rhima Coleman, Shyni Varghese 8:00AM Nuclear Scaling in Stem Cell Differentiation 1 D. Discher 1 Univ Pennsylvani, Philadelphia, PA 8:30AM ColVI and DCN's Role In Mechanotransduction And Scaffold Material Properties During Chondrogenesis 1 1 1,2 J. Twomey , B. Bulka , and A. Hsieh 1 2 University of Maryland, College Park, College Park, MD, University of Maryland, Baltimore, Baltimore, MA 8:45AM Differentiation of Human Adipose-Derived Stem Cells in Response to Mechanical Stimulation 1 2 2 1 1 1,2 K. Megerle , W. Cole , I. Mahaffey , P. Leucht , J. Chang , and A. Castillo 1 2 Stanford University School of Medicine, Palo Alto, CA, VAPAHCS, Palo Alto, CA 9:00AM Hippo-YAP Dependent Mechanosensitive Motor Neuron Differentiation of Human Pluripotent Stem Cells 1 1 1 1 1 1 Y. Sun , K. Aw Yong , W. Chen , R. Philson , S. Weng , and J. Fu 1 University of Michigan, Ann Arbor, MI 9:15AM Parsing Stem Cell Phenotypes Using High Content Imaging of Mechanotransductive Nuclear Reporters 1 1 1 1 2 2 3 1,4 A. Dhaliwal , S. Vega , V. Arvind , M. Brenner , Z. Zhang , Y. Mao , J. Kohn , and P. Moghe 1 2 Biomedical Engineering, Rutgers University, Piscataway, NJ, New Jersey Center for Biomaterials, Rutgers University, 3 4 Piscataway, NJ, Department of Chemistry & Chemical Biology, Rutgers University, Piscataway, NJ, Department of Chemical & Biochemical Engineering, Rutgers University, Piscataway, NJ BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 4 of 34 Track: Cardiovascular Engineering - OP-Sat-1-8 - Room 007B Angiogenesis Chairs: Bob Tranquillo, Sara Nunes Vasconcelos 8:00AM Recruitment and Programming of Endogeneous Progenitor Cells In Situ for Therapeutic Angiogenesis 1 1 2 1 L. Deveza , J. Choi , J. Ashoken , and F. Yang 1 2 Stanford University, Stanford, CA, San Jose State University, San Jose, CA 8:15AM Uncoupling Angiogenesis and Inflammation in Peripheral Artery Disease by Therapeutic Peptides with Injectable Microgels 1 1 1 1 1 1 A. Zachman , X. Wang , J. Tucker-Schwartz , S. Lee , M. Skala , and H-J. Sung 1 Vanderbilt University, Nashville, TN 8:30AM Syndesomes: A Novel Therapy For Peripheral Ischemia 1 1 1 1 1 1 S. Das , A. Monteforte , G. Singh , M. Martinez , A. Dunn , and A. Baker 1 University of Texas, Austin, Austin, TX 8:45AM A Fluid Shear Stress Threshold Regulates Angiogenic Sprouting 1 1 2 P. Galie , P. Janmey , and C. Chen 1 2 University of Pennsylvania, Philadelphia, PA, Boston University, Boston, MA 9:00AM Evaluation of Endothelial Progenitor Cells for Microvessel Tissue Engineering 1 1,2 1 1 1 E. Brown Peters , N. Christoforou , K. Leong , G. Truskey , and J. West 1 2 Duke University, Durham, NC, Khalifa University, Abu Dhabi, United Arab Emirates 9:15AM Physical Signals That Promote Vascularization of Capillary-Scale Channels 1 1 1 N. Boland , G. Covarrubias , and J. Tien 1 Boston University, Boston, MA Track: Cellular and Molecular Bioengineering - OP-Sat-1-9 - Room 007C New Innovator Session I Chairs: Cynthia Reinhart-King, Deborah Leckband 8:00AM Shrink Wrapping Cells in a Defined Extracellular Matrix to Modulate the Chemo-Mechanical Microenvironment 1 1 1 1 R. Palchesko , J. Szymanski , A. Sahu , and A. Feinberg 1 Carnegie Mellon University, Pittsburgh, PA 8:15AM Efficiency of Protease-activatable Virus Nanonodes Tuned Through Incorporation of Wild-type Capsid Subunits 1 1 1 1 1 1 M. Ho , J. Judd , B. Kuypers , M. Yamagami , F. Wong , and J. Suh 1 Rice University, Houston, TX 8:30AM Aqueous Two-Phase Printing of Tumor Spheroids For Drug Screening 1 1 1 2 1 E. Atefi , S. Lemmo , D. Fyffe , G. Luker , and H. Tavana 1 2 University of Akron, Akron, OH, University of Michigan, Ann Arbor, MI 8:45AM Quantitative Evaluation and Optimization of Co-drugging to Improve Anti-HIV Latency Therapy 1 1 1 1 2 1 V. Wong , L. Fong , N. Adams , Q. Xue , S. Dey , and K. Miller-Jensen 1 2 Yale University, New Haven, CT, Hubrecht Institute, Utrecht, Netherlands 9:00AM PAActivation of a Bacterial Mechanosensitive Channel in Mammalian Cells by Cytoskeletal Stress 1 1 1 1 1 A. Liu , J. Heureaux , D. Chen , V. Murray , and C. Deng 1 University of Michigan, Ann Arbor, MI BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 5 of 34 9:15AM Network Modeling Approach to Predict Myofibroblast Differentiation 1 1 1 A. Schroer , L. Ryzhova , and W. Merryman 1 Vanderbilt University, Nashville, TN Track: Orthopaedic and Rehabilitation Engineering, Tissue Engineering - OP-Sat-1-10 - Room 007D Musculoskeletal Tissue Engineering Chairs: Clark Hung, Warren Grayson 8:00AM Chondroinductive Biomaterials for Cartilage Tissue Engineering 1 M. Detamore 1 University of Kansas, Lawrence, KS 8:15AM Spatial Control of MSC Fate Using 3D Multi-compartment Scaffolds for Engineering Orthopedic Interfaces 1 1 1 1 1 1 W. Grier , L. Mozdzen , S. Caliari , D. Weisgerber , M. Boppart , and B. Harley 1 University of Illinois at Urbana-Champaign, Urbana, IL 8:30AM Dynamic Hydrostatic Pressure-induced Formation of Micropores in Mature Tissue-engineered Articular Cartilage 1 2 1 1 1 2 2 1 2 1 T-A. Kelly , S. Sirsi , A. Nover , C. Chen , A. Ditzel , P. Mountford , S. Etezazian , G. Ateshian , M. Borden , and C. Hung 1 2 Columbia University, New York, NY, University of Colorado at Boulder, Boulder, CO 8:45AM Engineering Craniofacial Bone And Skeletal Muscle From Adipose-Derived Stem Cells 1 W. Grayson 1 Johns Hopkins University, Baltimore, MD 9:00AM A Combined Experimental and Theoretical Approach to Designing Enzyme Degradable Hydrogels for Cartilage Tissue Engineering 1 1 1 1 1 1 S. Skaalure , S. Chu , U. Akalp , F. Vernerey , A. Doostan , and S. Bryant 1 University of Colorado, Boulder, CO 9:15AM The Use of Laminin-functionalized Hydrogels to Restore Pathological Nucleus Pulposus Cells of the Intervertebral Disc 1 1 1 1 1 1 1 1 P. Hwang , A. Francisco , L. Jing , W. Richardson , R. Isaacs , C. Brown , J. Chen , and L. Setton 1 Duke University, Durham, NC Track: Nano to Micro Technologies, Device Technologies and Biomedical Robotics - OP-Sat-1-11 - Room 008A Cells Tissues and Organs on Chip I Chairs: Keith Neeves, Maribel Vazquez 8:00AM Capillary Formation under Interstitial Flow in a Microfluidic Device for Liver Tissue Engineering 1 1 1 2 R. Sudo , Y. Abe , S. Menjo , and K. Tanishita 1 2 Keio University, Yokohama, Japan, Waseda University, Tokyo, Japan 8:15AM Simple Microfluidic Device for Automated, High-throughput Morphological Analysis of Stored Red Blood Cells 1 1 1 1 N. Piety , S. Gifford , X. Yang , and S. Shevkoplyas 1 University of Houston, Houston, TX 8:30AM Inflammation Mediated Modulation of Blood Brain Barrier In Vitro 1 1 1 1 1 2 1 A. Smith , J. Rosano , C. Garson , K. Bhatt , B. Prabhakarpandian , M. Aschner , and K. Pant 1 2 CFD Research, Huntsville, AL, Albert Einstein College of Medicine, Bronx, NY BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 6 of 34 8:45AM A Human Blinking 'Eye-on-a-chip' 1 1 J. Seo and D. Huh 1 University of Pennsylvania, Philadelphia, PA 9:00AM A Microfabricated Platform for Evaluating Prodrug Metabolism and Toxicity in a Hepatocyte-Cancer Model 1 1 1 1 1 1 1 1 1 S. Bale , R. Jindal , G. Sridharan , I. Golberg , W. McCarty , M. Hegde , A. Bhushan , L. Prodanov , O. Usta , and M. 1 Yarmush 1 Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School and Shriners Burns Hospital, Boston, MA 9:15AM A Microfluidic-Based Array for Large-Scale Ordering And High-Resolution Imaging Of Islets 1 1 1 1 1 M. Nourmohammadzadeh , J. Mendoza-Elias , Y. Xing , J. Oberholzer , and Y. Wong 1 University of Illinois at Chicago, Chicago, IL Track: Respiratory Bioengineering, Tissue Engineering - OP-Sat-1-12 - Room 008B Engineering Strategies for Lung Transplant & Regeneration Chairs: Daniel Weiss, Samir Ghadiali 8:00AM Ex-Vivo Lung Perfusion – A Bench to Bedside Platform for Pulmonary Investigation 1 B. Whitson 1 The Ohio State University, Columbus, OH 8:15AM Design and Validation of a Clinical-Scale Biomimetic Whole-Lung Bioreactor 1 1 1 1,2 1 1,2 J. Charest , T. Okamoto , A. Yasuda , S. Gilpin , D. Mathisen , and H. Ott 1 2 Massachusetts General Hospital, Boston, MA, Harvard Medical School, Boston, MA 8:30AM Enhanced Reseeding of Decellularized Rodent Lung Airway and Vasculature 1 1 1 2 1 1 3 1 C. Stabler , S. Lecht , M. Barakat , L. Caires , A. Rylander , R. Chiaverelli , E. Schulman , C. Marcinkiewicz , and P. 1 Lelkes 1 2 3 Temple University, Philadelphia, PA, Federal University of Juiz de Fora, Juiz de Fora, Brazil, Drexel University College of Medicine, Philadelphia, PA 8:45AM Mechanical Control of Airway Branching Morphogenesis 1 1 1 V. Varner , J. Gleghorn , and C. Nelson 1 Princeton University, Princeton, NJ 9:00AM Engineered Cartilaginous Structures for Tracheal Tissue Replacement 1 2 1 2 1 A. Dikina , H. Strobel , B. Lai , M. Rolle , and E. Alsberg 1 2 Case Western Reserve University, Cleveland, OH, Worcester Polytechnic Institute, Worcester, MA 9:15AM An Alginate-Based Pulmonary Patch For Repairing Pleural Injuries 1 1 1 1 1 1 S. Fenn , D. Wagner , P. Saunders , P. Charron , D. Weiss , and R. Oldinski 1 University of Vermont, Burlington, VT Track: Device Technologies and Biomedical Robotics, Translational Biomedical Engineering - OP-Sat-1-13 - Room 201 Biosensors I: Materials and Techniques Chairs: J-C Chiao, Jeff LaBelle 8:00AM Advancing Silicon Photonics for Clinical Applications 1 D. Ratner 1 University of Washington, Seattle, WA BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 7 of 34 8:30AM Macromolecularly Imprinted Polymers on the Surface of Nanoparticle Supports for Low-Cost Biosensors 1 2 1 H. Culver , C. Fauvarque Nuytten , and N. Peppas 1 2 University of Texas at Austin, Austin, TX, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland 8:45AM A High Density Electrochemical Imaging System for Understanding Cell-to-Cell Communication 1 1 1 1 1 1 1 1 1 1 W. Wilson , K. Schoelfield , J. Wydallis , R. Feeny , W. Tejio , T. Kern , S. Lantvit , C. Henry , S. Tobet , M. Reynolds , 1 and T. Chen 1 Colorado State University, Fort Collins, CO 9:00AM Protease Detection Assay Based on Aggregation of Stimulus-Responsive Polypeptides 1 1 1 A. Ghoorchian , A. Chilkoti , and G. Lopez 1 Duke University, Durham, NC 9:15AM Up-Regulation of Metabolites for Early Detection of Bacterial Pathogens in Human Biofluids 1 1 1 H. Sismaet , T. Webster , and E. Goluch 1 Northeastern University, Boston, MA Track: Drug Delivery, Cancer Technologies - OP-Sat-1-14 - Room 103B Cancer Drug Delivery I Chairs: Natalie Artzi, Hao Cheng 8:00AM Role of Endocytosis in Electrotransfection of Tumor Cells 1 1 1 M. Wu , C-C. Chang , and F. Yuan 1 Duke University, Durham, NC 8:15AM Mapping The CXCR4 Receptor On Breast Cancer Cells By AFM: A Tool For Engineering Targeted Drug Delivery Vehicles 1 1 B. WANG and D. Auguste 1 The City College of New York, New York, NY 8:30AM Systemic Delivery of Liposome-Anchored Cytokines Elicits Antitumor Immunity Without Lethal Toxicity 1,2,3 1,2,3,4,5 Y. Zhang and D. Irvine 1 Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, 2 3 Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, Koch Institute for 4 Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, Ragon Institute of 5 Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, MA, Howard Hughes Medical Institute, Chevy Chase, MD 8:45AM Core/Shell Systems for Improved Control of the Externally Triggered Release of Chemotherapeutics 1 1 1 1 J. Peters , N. Lizana , I. Verma , and N. Peppas 1 The University of Texas at Austin, Austin, TX 9:00AM A Long Circulating PVX-Based Nanoparticle for Enhanced Tumor Homing and Therapeutic Payload Delivery 1 1 1 1 1 K. Lee , S. Shukla , K. Weber Bonk , R. Keri , and N. Steinmetz 1 Case Western Reserve University, Cleveland, OH BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 8 of 34 Track: Neural Engineering, Device Technologies and Biomedical Robotics - OP-Sat-1-15 - Room 202A Brain-computer Interfaces Chairs: Chris Passaglia, Erkin Seker 8:00AM Role of Interleukin 1β Converting Enzyme on Recording Performance and the Reactive Tissue Response Around Chronic Neural Electrode 1 1 1 1 1 1 1 T. Kozai , X. Li , L. Bodily , E. Caparosa , D. Carlisle , R. Friedlander , and X. Cui 1 University of Pittsburgh, Pittsburgh, PA 8:15AM Understanding the Immune Response to Intracortical Microelectrodes 1,2 1,2 1,3 1,2 1 1 1 1 J. Hermann , M. Ravikumar, PhD , J. Jiang , J. Nguyen , S. Sunil , C. Wong , A. Soffer , V. Srivastava , D. Taylor, 2,3 1,2 PhD , and J. Capadona, PhD 1 2 Case Western Reserve University, Cleveland, OH, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, 3 Cleveland Clinic Lerner Research Institute, Cleveland, OH 8:30AM The Spatial Distribution of FBR Biomarkers Correlates with Recording Performance in Rats 1 1 1 N. Nolta , M. Christensen , and P. Tresco 1 University of Utah, Salt Lake City, UT 8:45AM Modeling Mechanics of Flexible Neural Probes Coated in an Ultra-fast Degrading Polymer for Optimizing Probe Design 1 1 2 2 2 1 1 S. Singh , M-C. Lo , V. Damodaran , H. Kaplan , J. Kohn , J. Zahn , and D. Shreiber 1 2 Rutgers University, Piscataway, NJ, New Jersey Center for Biomaterials, Piscataway, NJ 9:00AM Flexible Neural Micoprobes Coated with a Fast Degrading Polymer as an Aid to Tissue Insertion 1 1 1 1 1 1 1 1 1 M-C. Lo , S. Singh , V. B. Damodaran , S. Wang , H. M. Kaplan , K. Coffey , D. Barker , J. D. Zahn , D. I. Shreiber , and J. 1 Kohn 1 Rutgers, the State University of New Jersey, Piscataway, NJ 9:15AM Extracellular Matrix Coatings for CNS Neural Recording Arrays 1 1 1 1 R. Oakes , M. Polei , J. Skousen , and P. Tresco 1 University of Utah, Salt Lake City, UT Track: New Frontiers and Special Topics, Device Technologies and Biomedical Robotics - OP-Sat-1-16 - Room 202B Global Health I Chairs: Sergey Shevkoplyas, Leo Wan 8:00AM A Low-cost, Paper-based Assay for Diagnosis of Sickle Cell Disease in Resource-limited Settings 1 1 2 2 1 N. Piety , X. Yang , B. Dinu , A. George , and S. Shevkoplyas 1 2 University of Houston, Houston, TX, Baylor College of Medicine, Houston, TX 8:30AM GlucoSense: Design of a Low Cost Diabetes Glucometer System 1 1 1 1 K. Gainey , T. Ovington , J. DesJardins , and D. Dean 1 Clemson University, Clemson, SC 8:45AM Immunomodulatory Nanoparticles Ameliorate Disease in the Leishmania (Viannia) panamensis Mouse Model 1 1 2 1 1 1 A. Siefert , A. Ehrlich , M. Corral Caridad , K. Goldsmith-Pestana , D. McMahon-Pratt , and T. Fahmy 1 2 Yale University, New Haven, CT, Universidad Complutense de Madrid, Madrid, Spain 9:00AM Towards Development of an Autonomous Network of BacteriaBots: High-Throughput Spatiotemporal Characterization of Bacterial Quorum-Sensing Response 1 1 1 1 1 A. Sahari , M. Traore , A. Stevens , B. Scharf , and B. Behkam 1 Virginia Tech, Blacksburg, VA BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 9 of 34 9:15AM Increasing Access to HIV Medication in Developing Countries: An Operational, Feasibility Study in Zambia 1 1 1 A. Dahinten , J. Ekuta , and R. Malkin 1 Duke University, Durham, NC Track: Biomedical Imaging and Optics - OP-Sat-1-17 - Room 203A Ultrasound Imaging Chairs: Baohong Yuan, Paul Carson 8:00AM Development and Application of Ultrasound Techniques for Investigating Pathogenesis in Experimental Abdominal Aortic Aneurysms 1 1 1 1 1 1 1 1 1 1 E. Phillips , A. Yrineo , H. Schroeder , F. Damen , A. Bogucki , S. Jubaer , A. Jackson , R. Foley , N. Blaize , J-X. Cheng , 1 and C. Goergen 1 Purdue University, West Lafayette, IN 8:15AM RSNA QIBA Ultrasound Shear Wave Speed: Sources of Variability in Phantoms, Simulations and Humans 1 2 3 4 5 5 6 7 8 5 P. Carson , A. Milkowski , T. Hall , B. Garra , K. Nightingale , M. Palmeri , A. Samir , S. Chen , T. Lynch , N. Rouze , M. 6 5 Dhyani , and D. Sullivan 1 2 3 4 Univ. of Michigan, Ann Arbor, MI, Siemens Ultrasound, Issaquah, WA, Univ. of Wisconsin, Madison, WI, Veterans 5 6 7 Health System, Hyattsville, MD, Duke Univ., Durham, NC, Mass. Gen'l Hospital, Boston, MA, Mayo Clinic, Rochester, 8 MN, CIRS, Inc., Norfolk, VA 8:30AM Ultrasound and Photoacoustic Imaging of Anatomical and Functional Indicators of Lymph Node Metastasis 1 1 G. Luke and S. Emelianov 1 The University of Texas at Austin, Austin, TX 8:45AM Formulation and In Vitro Characterization of Targeted Lipid-Pluronic Nanobubbles 1 1 1 1 P. Kota , C. Hernandez , H. Wu , and A. Exner 1 Case Western Reserve University, Cleveland, OH 9:00AM Skeletal Imaging and Assessment Using Hand-Held Focal Quantitative Ultrasound Technology 1 1 1 1 J. Muir , L. Lin , J. Cheng , and Y-X. Qin 1 Stony Brook University, Stony Brook, NY 9:15AM Bipolar Nanosecond Electric Pulses Display Reduced Efficacy Due to Acoustic Interference 1 2 2 3 3 1 C. Roth , R. Barnes , S. Maswadi , B. Ibey , H. Beier , and R. Glickman 1 2 3 UTHSCSA, San Antonio, TX, UTSA, San Antonio, TX, Air Force Research Laboratories, San Antonio, TX Track: Biomedical Imaging and Optics - OP-Sat-1-18 - Room 203B Optical Imaging and Microscopy I Chairs: Bernard Choi, Ken Tichauer 8:00AM Near Infrared Fluorescent Neural Progenitor Cells to Track Differentiation and Tissue Innervation 1,2 1,2 2 2 2 1,2 A. Mohs , S. Raghavan , R. Gilmont , S. Somara , F. Marini , and K. Bitar 1 2 Wake Forest - Virginia Tech School of Biomedical Engineering and Sciences, Winston-Salem, NC, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC 8:15AM Imaging Three-Dimensional Nanoscale Morphometry of Type I Collagen Gels Using Focused Ion Beam Scanning Electron Microscopy 1 1 1 S. Reese , N. Farhang , and J. Weiss 1 University of Utah, Salt Lake City, UT BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 10 of 34 8:30AM Light-sheet Single-Molecule Super-resolution Imaging of Tissues 1 1 1 1 Y. Hu , Z. Katz , B. Lillemeier , and H. Cang 1 Salk Institute, La Jolla, CA 8:45AM Intracellular Three-Dimensional Single-Particle Tracking with Multiplexed Two-Photon Excitation 1 1 1 1 1 E. Perillo , Y-L. Liu , C. Liu , H-C. Yeh , and A. Dunn 1 The University of Texas Austin, Austin, TX 9:00AM Large Scale, High Resolution Imaging with a Simple and Robust Super-resolution Light Sheet Microscopy 1 P. Fei 1 UCLA, Los Angeles, CA 9:15AM Ultra-Wide Field-Of-View Gigapixel Fluorescent Imaging System Using A Modified Flatbed Scanner 1 1 1 1 1 1 1 1,2 Z. Göröcs , Y. Ling , M. Yu , D. Karahalios , K. Mogharabi , K. Lu , Q. Wei , and A. Ozcan 1 2 University of California, Los Angeles, Los Angeles, CA, California NanoSystems Institute, Los Angeles, CA Track: Cancer Technologies, Nano to Micro Technologies - OP-Sat-1-19 - Room 103A Nanotechnologies for Cancer I Chairs: Carlos Rinaldi, Craig Duvall 8:00AM Resources For Preclinical Characterization Of Nanomaterials For Cancer Diagnosis, Imaging & Therapy 1 1 1 1 N. Panaro , S. Stern , A. Patri , and S. McNeil 1 Leidos Biomedical Research, Frederick, MD 8:15AM In Vivo Targeting of Tumor Associated Macrophages Using Mannosylated Endosomal-Escape Nanoparticles 1 1 1 1 1 1 1 R. Ortega , W. Barham , I. McFadden , O. Tikhomirov , K. Sharman , F. Yull , and T. Giorgio 1 Vanderbilt University, Nashville, TN 8:30AM Targeting Nanotechnology to Invasive Brain Tumors 1 1 1 1 1 1 1 2 1 1 P. Peiris , A. Abramowski , L. Bauer , R. Toy , E. Doolittle , S. Rao , S. Shah , K. Ghaghada , S. Brady-Kalnay , J. Basilion , 1 1 M. Griswold , and E. Karathanasis 1 2 Case Western Reserve University, Cleveland, OH, Texas Children's Hospital, Houston, TX 8:45AM A Novel Triple Negative Breast Cancer Theranostic Target for Nanomedicine 1 2 P. Guo and D. Auguste 1 2 Boston Children's Hospital, Boston, MA, City College of New York, New York, NY 9:00AM In Vivo Targeting of Adoptively Transferred T-cells with Nanoparticles for Cancer Immunotherapy 1,2 1,2,3,4 Y. Zheng and D. Irvine 1 2 Massachusetts Institute of Technology, Cambridge, MA, Koch Institute for Integrative Cancer Research, MIT, 3 Cambridge, MA, Ragon Institute of Massachusetts General Hospital, MIT and Harvard University, Cambridge, MA, 4 Howard Hughes Medical Institute, Chevy Chase, MD 9:15AM In Vivo Multiplex Photoacoustic Molecular Imaging for Optimization of Nanoparticle Targeting and Kinetics 1 1 1 C. Bayer , G. Luke , and S. Emelianov 1 The University of Texas at Austin, Austin, TX BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 11 of 34 Track: Biomedical Engineering Education (BME) - OP-Sat-1-20 - Room 204A Novel Laboratory Modules Chairs: Ann Saterbak, Chris Geiger 8:00AM Teaching Sequential Design of Experiments and Biomedical Process Optimization 1 J. Audet 1 University of Toronto, Toronto, ON, Canada 8:15AM "Building Blocks" for Inventing Instruments in the Classroom 1 1 1 1 D. Hill , L. Anderson , C. Hill , and W. Grover 1 University of California, Riverside, Riverside, CA 8:30AM Receiving Feedback from Instructor and Peers Increases the Quality of Written Reports in a Biomedical Instrumentation Laboratory Course 1 R. Ramos 1 Rice University, Houston, TX 8:45AM Integrating 3D Additive Manufacturing Technologies into a Tissue Engineering Lab Course 1 A. Feinberg 1 Carnegie Mellon University, Pittsburgh, PA 9:00AM A Two-Dimensional Motion Analysis Laboratory for Introductory Courses in Biomedical Engineering 1 1 C. Henak and S. Archer 1 Cornell University, Ithaca, NY 9:15AM Cloud Experimentation And Biotic Games As Novel Media For Bioengineering Education 1 1 1 1 I. Riedel-Kruse , Z. Hossain , A. Chung , and N. Cira 1 Stanford Bioengineering, Stanford, CA SPECIAL SESSION – 8:00 AM – 9:30 AM – Ballroom A Advanced Biomanufacturing: Application towards the Next Generation Therapies and Diagnostics Advanced Biomanufacturing is an emerging field in biomedical engineering. Unlike conventional bioprocessing technologies, advanced biomanufacturing builds on the groundbreaking discoveries such as 3D additive manufacturing, genome editing, cell reprogramming and transdifferentiation, systems and synthetic biology, stem cell biology, computational modeling, micro and nanofabrication, material genomes, biomaterials, tissue engineering and regenerative medicine. A group of leading scientists have worked together and recently launched a BMES special interest group (SIG) for advanced biomanufacturing (ABioM-SIG). The objective of the BMES SIG is to bring academic and industrial leaders together to promote the development of advanced biomanufacturing, foster collaborations among investigators in the field, and create a new mode of educating and training the next generation leaders and workforce in advanced biomanufacturing. This inaugural session is the BMES ABioM-SIG’s first official session to discuss opportunities and grand challenges in advanced biomanufacturing and to lay out a strategic plan to spur research, education, and industry growth and innovation in advanced biomanufacturing towards significant benefits to the patient population and the society at large. BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 12 of 34 SATURDAY, October 25, 2014 - 1:30 PM - 3:00 PM PLATFORM SESSIONS – Sat - 2 Track: Tissue Engineering, Stem Cell Engineering - OP-Sat-2-1 - Room 001A Adult Stem Cells in Tissue Engineering Chairs: Liping Tang, Michelle Dawson 1:30PM TGF-β 1 Pretreatment Improves The Function Of Mesenchymal Stem Cells In The Wound Bed 1 1 1 D. Ghosh , D. McGrail , and M. Dawson 1 Georgia Institute of Technology, Atlanta, GA 1:45PM Photocrosslinkable, Biodegradable Hydrogels with Controlled Cell Adhesivity for Tunable siRNA Delivery to Encapsulated hMSCs 1 1 1 1 M. Nguyen , D. Schapira , A. McMillan , and E. Alsberg 1 Case Western Reserve University, Cleveland, OH 2:00PM Gelatin-based Injectable Microsphers for Encapsulating Mesenchymal Stem Cells 1 1 1 1 B. Sung , S. Shaffer , C. Kim , and M-H. Kim 1 Kent State University, Kent, OH 2:15PM A Novel ‘Differentiation Niche’ Promoting Stem Cell Differentiation to Smooth Muscle Lineage 1 1 L. Velutheril Thomas and J. L.West 1 Duke University, Durham, NC 2:30PM Hypoxic Modulation of Mesenchymal Stem Cells Affects Macrophage Function for Ischemic Tissue Repair 1 1 1 1 L. Ricles , E. Chung , N. Kopcho , and L. Suggs 1 The University of Texas at Austin, Austin, TX 2:45PM Tissue Regeneration Using Scaffold-mediated Autologous Progenitor Cell Responses In Vivo 1 1 2 2 3 4 4 1 A. Nair , J. Shen , C. Zhang , R. Saxena , J. Borrelli , R. Tran , J. Yang , and L. Tang 1 2 University of Texas at Arlington, Arlington, TX, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, 3 4 Texas Health Arlington Memorial Hospital, Arlington, TX, Pennsylvania State University, University Park, PA Track: Biomaterials, Cellular and Molecular Bioengineering - OP-Sat-2-2 - Room 001B Biomaterials for Immunoengineering I Chairs: Jeffrey Capadona, Adam Ekenseair 1:30PM The Aggregate Structure of Self-Assembled Nanocarriers Specifies Their In Vivo Uptake By Antigen Presenting Cell Subsets 1 2 2 E. Scott , A. de Titta , and J. Hubbell 1 2 Northwestern University, Evanston, IL, EPFL, Lausanne, Switzerland 1:45PM Nanomaterials-based Vaccines for Cocaine Addiction 1 1 1 1 1 1 1 R. Appavu , C. Ding , S. Stutz , Y. Ding , K. Cunningham , J. Zhou , and J. Rudra 1 Department of Pharmacology and Toxicology, Center for Addiction Research, University of Texas Medical Branch, Galveston, TX 2:00PM M2e Conjugated Gold Nanoparticles Protect Against H1N1, H3N2 and H5N1 Influenza A Viruses 1 2 1 W. Tao , E. Tarbet , and H. Gill 1 2 Texas Tech Univeristy, Lubbock, TX, Utah State University, Logan, UT BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 13 of 34 2:15PM Immunogenicity and Adjuvanticity of Biologically Derived Nanoparticles 1 1 1 1 Y. Wang , Y. Huang , L. Sun , and M. Zhang 1 Ohio State University, Columbus, OH 2:30PM Membrane-interacting, Amphiphilic Gold Nanoparticles: Mechanisms for Bilayer-embedding and Applications in Peptide Vaccine Therapy 1 1 1 1 P. Atukorale , K. Moynihan , D. Yun , and D. Irvine 1 Massachusetts Institute of Technology, Cambridge, MA 2:45PM Pre-clinical Development of a Biomaterial-based Microparticle Vaccine for Type 1 Diabetes Attenuation 1 1 1 1 1 1 J. Lewis , M. Carstens , N. Dolgova , C-Q. Xia , M. Clare-Salzler , and B. Keselowsky 1 University of Florida, Gainesville, FL Track: Biomaterials - OP-Sat-2-3 - Room 006A Biomaterials Design I Chairs: Abigail Koppes, Matt Kipper 1:30PM Biomaterials Design for Enhanced Vascularization and Healing 1 G. Vunjak-Novakovic 1 Columbia University, New York, NY 2:00PM Periadventitial Application of Rapamycin-Loaded Nanoparticles Produces Sustained Inhibition of Vascular Restenosis 1 2 2 2 1,3 G. Chen , X. Shi , L. Guo , K. Kent , and S. Gong 1 Materials Science Program and Wisconsin Institute for Discovery, University of Wisconsin–Madison, Madison, WI, 2 3 Department of Surgery, University of Wisconsin Hospital and Clinics, Madison, WI, Department of Biomedical Engineering, University of Wisconsin–Madison, Madison, WI 2:15PM Polysaccharide Mediated Pore Formation For 3D Myotube Formation 1 1 2 1 1 M. Rich , M. Lee , N. Marshall , J. Chen , and H. Kong 1 2 University of Illinois, Urbana, IL, Drake University, Des Moines, IA 2:30PM Polycarbonates Built From the Polyhydroxyl Natural Products Quinic Acid and Glucose: Tuning the Thermal, Mechanical, and Surface Properties for Degradable Medical Plastics Applications 1 1 1 1 1 1 1 1 L. Link , T. Gustafson , A. Lonnecker , J. Raymond , K. Hearon , C. Maher , D. Maitland , and K. Wooley 1 Texas A&M University, College Station, TX 2:45PM Rheological and Mechanical Characterization of Biocomposites Based on Chitosan with Potential Use as Bone Adhesives 1 1 1 1 1 1 1 L. Pinzon , F. Cedano , F. Salcedo , J. Casas , C. Moreno , J. Briceno , and D. Tabima 1 Universidad de los Andes, Bogota, Colombia Track: Biomechanics, Cardiovascular Engineering - OP-Sat-2-4 - Room 006B Aortic Biomechanics Chairs: Craig Goergen, Zhijie Wang 1:30PM Translation of AAA Rupture Risk Assessment: Wall Mechanics and Geometric Quantification 1 2 3 S. Raut , J. Shum , and E. Finol 1 2 3 University of Texas at Austin, Austin, TX, Carnegie Mellon University, Pittsburgh, PA, University of Texas at San Antonio, San Antonio, TX BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 14 of 34 1:45PM Role of Aneurysm on Biomechanics of Radially-Oriented Fibers in Human Ascending Thoracic Aorta 1 2 2 3 2,3 2 2 2 A. Tsamis , S. Pal , J. Phillippi , S. Pasta , A. D’Amore , T. Gleason , D. Vorp , and S. Maiti 1 2 3 Carnegie Mellon University, Pittsburgh, PA, University of Pittsburgh, Pittsburgh, PA, Fondazione Ri.MED and DICGM University of Palermo, Palermo, Italy 2:00PM The Role of Heparanase in Aneurysm Development and Cardiac Function 1 1 V. Le and A. Baker 1 University of Texas at Austin, Austin, TX 2:15PM A Biochemomechanics Model of Stress-Mediated Vascular adaptation in Normal Physiological Conditions 1 1 H. Getachew and S. Baek 1 Michigan State University, East Lansing, MI 2:30PM Viscoelastic Characterization of Damage Progress in Porcine Aortic Tissues In Vitro 1 1 1 1 1 1 M. Sharma , A. Valdevit , C. Perlman , Y. Wu , A. Kharge , and D. Shahmirzadi 1 Stevens Institute of Technology, Hoboken, NJ 2:45PM An Alternative Method to Measure the Diameter of Abdominal Aortic Aneurysms Using Maximally Inscribed Spheres 1 1 1 1 2 1 H. Gharahi , B. Zambrano , C. Lim , J. Choi , W. Lee , and S. Baek 1 2 Michigan State University, East Lansing, MI, Seoul National University Hospital, Seoul, Korea, Republic of Track: Biomechanics - OP-Sat-2-5 - Room 006C Ocular Biomechanics Chairs: Ross Ethier, Matthew Reilly 1:30PM Effect Of Cell Stiffness On Transcellular And Paracellular Pore Formation In Schlemm's Canal Cells 1 2 2 1 2 1 2 3 M. Johnson , S. Braakman , R. Pedrigi , A. Vahabikashi , J. Sherwood , R. Vargas-Pinto , R. Gupta , K. Perkumas , W. 3 4 2 Stamer , C. Ethier , and D. Overby 1 2 3 Northwestern University, Evanston, IL, Imperial College London, London, United Kingdom, Duke University, Durham, 4 NC, Georgia Tech, Atlanta, GA 1:45PM The Role of Ocular Lens-Specific Proteins In Determining Lens Optical and Mechanical Properties 1 1 2 3,4 4 1 1 1 M. Reilly , S. Kumar , B. Rapp , N. Ravi , P. Hamilton , M. Leroux , A. Shiels , and B. Marchand 1 2 3 University of Texas at San Antonio, San Antonio, TX, Indiana University Health, Indianapolis, IN, Washington 4 University in St. Louis, St. Louis, MO, Department of Veterans Affairs, St. Louis, MO 2:00PM Effect of Orbital Geometry on Eye Response to Survivable Primary Blast Overpressure 1 1 1 V. Alphonse , A. Kemper , and S. Duma 1 Virginia Tech - Wake Forest University Center for Injury Biomechanics, Blacksburg, VA 2:15PM Matrix Stiffening Contributes to Retinal Endothelial Inflammation Associated with Diabetic Retinopathy 1 1 1 1 X. Yang , H. Scott , S. Ardekani , and K. Ghosh 1 University of California, Riverside, Riverside, CA 2:30PM Ocular Compliance in Mice 1 2 3 2 1 S. Schwaner , J. Sherwood , E. Geisert , D. Overby , and C. Ethier 1 2 3 Georgia Institute of Technology, Atlanta, GA, Imperial College London, London, United Kingdom, Emory University, Atlanta, GA 2:45PM Primary Blast Influences Incidence and Severity of Ocular Injury in a Porcine Eye Model 1 2 3 1,4 1 1 4 1 D. Sherwood , B. Lund , R. Glickman , W. Sponsel , W. Gray , R. Watson , K. Thoe , and M. Reilly 1 2 University of Texas San Antonio, San Antonio, TX, U.S. Army Institute of Surgical Research, Ft Sam Houston, TX, 3 4 University of Texas Health Science Center at San Antonio, San Antonio, TX, WESMDPA, San Antonio, TX BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 15 of 34 Track: Cancer Technologies, Nano to Micro Technologies - OP-Sat-2-6 - Room 006D Microtechnologies for Cancer I Chairs: Rafael Davalos, Samir Iqbal 1:30PM Dielectrophoretic Isolation and Detection of Cancer Related Circulating Cell Free DNA Biomarkers from Blood and Plasma 1 M. Heller 1 University of California San Diego, La Jolla, CA 1:45PM Circulating Tumor Cell Cluster-Chip 1 1 1 1 1 1 1 1 1 A. Sarioglu , N. Aceto , N. Kojic , M. Donaldson , M. Zeinali , B. Hamza , A. Engstrom , H. Zhu , T. Sundaresan , D. 1 1 1 1 1 1 1 1 1 1 Miyamoto , X. Luo , A. Bardia , B. Wittner , S. Ramaswamy , T. Shioda , D. Ting , S. Stott , R. Kapur , S. Maheswaran , 1 1 D. Haber , and M. Toner 1 Harvard Medical School, Charlestown, MA 2:00PM Platelet-Targeted Microfluidic Isolation of Circulating Tumor Cells 1 1 1 1 1 1 1 1 2 X. Jiang , A. Khankhel , E. Reategui , M. Zeinali , M. Phillips , F. Fachin , A. Hoang , A. Jensen , L. Sequist , S. 2 2 1 1 Maheswaran , D. Haber , S. Stott , and M. Toner 1 2 Massachusetts General Hospital and Harvard Medical School, Boston, MA, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA 2:15PM Non-Fixative Preservative Solution for Stabilizing Circulating Tumor Cells in Whole Blood 1 1 1 1 1 1 1 1 1 1 R. Sandlin , K. Wong , T. Carey , A. Khankhel , A. Shank , J. Walsh , D. Irimia , S. Maheswaran , D. Haber , S. Stott , and 1 M. Toner 1 Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 2:30PM Shear-responsive Nanocoating for Single Circulating Tumor Cell DNA Analysis 1,2 2,3 2,3 1 4 1 1,2 1 4 3 E. Reátegui , N. Aceto , J. Sullivan , A. Jensen , E. Lim , M. Zeinali , J. Martel , A. Aranyosi , W. Li , A. Bardia , L. 3 3,5 3 4 1,2 1,3 Sequist , D. Haber , S. Maheswaran , P. Hammond , M. Toner , and S. Stott 1 2 Center for Engineering in Medicine, Massachusetts General Hospital, Charlestown, MA, Harvard Medical School, 3 4 Boston, MA, Massachusetts General Hospital Cancer Center, Charlestown, MA, Massachusetts Institute of 5 Technology, Cambridge, MA, Howard Hughes Medical Institute, Chevy Chase, MD 2:45PM Detecting DNA Damage Electrically With Solid-State Nanopores 1 1 1 2 M. Marshall , J. Ruzicka , E. Taylor , and A. Hall 1 2 University of North Carolina Greensboro, Greensboro, NC, Wake Forest University School of Medicine, WinstonSalem, NC Track: Stem Cell Engineering, Tissue Engineering - OP-Sat-2-7 - Room 007A Directing Stem Cell Differentiation Chairs: Steven George, Randolph Ashton 1:30PM Membrane Capacitance Indicates Neural Stem Cell Fate Via Specific Cell Surface Molecules 1 1 1 1 1 1 1 J. Nourse , S. Ahmed , J. Arulmoli , B. Povieng , L. McDonnell , C. Soemardy , and L. Flanagan 1 UNIVERSITY OF CALIFORNIA IRVINE, Irvine, CA 1:45PM Nanog Restores the Lost Myogenic Capacity of Senescent Stem Cells 1 1 2 1 P. Mistriotis , M. Liang , L. Karacosta , and S. Andreadis 1 2 University at Buffalo, Amherst, NY, University at Buffalo, Buffalo, NY 2:00PM Oxygenation Augments Myogenic Differentiation of Mesenchymal Stem Cells under Ischemic Conditions 1 1 1 1 1 1 1 1 Y. Xu , M. Fu , Z. Li , X. Li , Z. Fan , P. Anderson , Z. Liu , and J. Guan 1 The Ohio State University, Columbus, OH BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 16 of 34 2:15PM Direct Conversion of Skin Stem Cells into Functional Neural Crest Fate 1 1 V. Bajpai and S. Andreadis 1 University at Buffalo, Amherst, NY 2:30PM Directed In Vitro Myogenesis of Human Embryonic Stem Cells and Their In Vivo Delivery Using Biomimetic Materials 1 2 2 2 S. Varghese , H. Kabra , Y. Hwang , and M. Kar 1 2 UC San Diego, La Jolla, CA, UCSD, La Jolla, CA Track: Cardiovascular Engineering - OP-Sat-2-8 - Room 007B Heart Valves and Stents I Chairs: Michael Sacks, Craig Simmons 1:30PM Simulation of Heart Valve Biomaterial Fatigue 1 M. Sacks 1 University of Texas at Austin, Austin, TX 1:45PM A Comparative Analysis of Valvular Cell Calcification from Coronary or Non-coronary Aortic Valve Cusps 1 1 1 S. Masjedi , R. Acharya , and Z. Ferdous 1 University of Tennessee, Knoxville, TN 2:00PM Pharmacological Targeting of Cadherin-11 Prevents Valvular Calcific Nodule Formation 1 1 M. Bowler and W. Merryman 1 Vanderbilt University, Nashville, TN 2:15PM The Role of Valve Interstitial Cell Structure on Initiation and Progression of Aortic Valve Disease 1 1 1 A. Razavi , J. Carradini , and K. Balachandran 1 University of Arkansas, Fayetteville, AR 2:30PM Novel Mechanism of Directing Osteoblastic-like Differentiation in Valvular Interstitial Cells 1 1 E. Hedberg-Dirk and M. Rush 1 University of New Mexico, Albuquerque, NM 2:45PM Effect of Boundary Stiffness on Maintenance of Myofibroblast Phenotype 1 1 M. Kural and K. Billiar 1 Worcester Polytechnic Institute, Worcester, MA Track: Cellular and Molecular Bioengineering - OP-Sat-2-9 - Room 007C New Innovator Session II Chairs: Cynthia Reinhart-King, Deborah Leckband 1:30PM The Relative Role of Soluble Guanylyl Cylase Dependent and Independent Pathways in Nitric Oxide Inhibition of Platelet Aggregation Under Flow 1 2 2 1 J. Sylman , S. Lantvit , M. Reynolds , and K. Neeves 1 2 Colorado School of Mines, Golden, CO, Colorado State University, Ft Collins, CO 1:42PM Depolarization of Resting Membrane Potential Stimulates Neonatal Cardiomyocyte Proliferation In Vitro 1 1 1 1,2 J-Y. Lan , C. Williams , M. Levin , and L. Black III 1 2 Tufts University, Medford, MA, Tufts University School of Medicine, Boston, MA 1:54PM Membranes Promote Endothelial Differentiation of Adipose-Derived Stem Cells and Perivascular Interactions 1 2 1 1 A. Mazzocchi , J-P. DesOrmeaux , A. Man , and T. Gaborski 1 2 Rochester Institute of Technology, Rochester, NY, SiMPore Inc., West Henrietta, NY BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 17 of 34 2:06PM Microscale Bio-adhesive Hydrogel Arrays for Cell Engineering Applications 1 1 2 1 R. Patel , A. Purwada , A. Gaharwar , and A. Singh 1 2 Cornell University, Ithaca, NY, Texas A&M University, College Station, TX 2:18PM Nuclear Deformability Constitutes a Rate-limiting Step During Cell Migration in 3-D Environments 1 1 1 1 P. Davidson , C. Denais , M. Bakshi , and J. Lammerding 1 Cornell University, Ithaca, NY 2:30PM Electrospun Polymers for Reprogramming Human Cells 1 1 1 1 1 1 T. Cordie , T. Harkness , X. Jing , H-Y. Mi , L-S. Turng , and K. Saha 1 University of Wisconsin-Madison, Madison, WI 2:4PM Endometriotic Epithelial Cell Response to Macrophage-Secreted Factors is Dependent on Extracellular Matrix Context 1 1 1 2 1 K. Pollock , T. Jaraczewski , M. Carroll , D. Lebovic , and P. Kreeger 1 2 University of Wisconsin-Madison, Madison, WI, University of Wisconsin School of Medicine and Public Health, Madison, WI Track: Drug Delivery - OP-Sat-2-10 - Room 007D Targeted Drug Delivery I Chairs: Yun Wu, Michael Davis 1:30PM A Universal Protein Tag for Delivery of SiRNA - Aptamer Chimeras 1 2 H. Liu and X. Gao 1 2 Georgia Regents University, Evans, GA, University of Washington, Seattle, WA 1:45PM Local Inhibition of MMPs in Abdominal Aortic Aneurysm Rat Model Using Anti-elastin Decorated Nanoparticles Loaded with Batimastat 1 1 1 1 N. Nosoudi , A. Sinha , P. Nahar , and N. Vyavahare 1 Clemson University, Clemson, SC 2:00PM Membrane-Embedding Nanoparticles as Cytosolic Drug Delivery Vehicles for Infectious Diseases. 1 2 2 3 Y-S. Yang , A. Bekdemir , F. Stellacci , and D. Irvine 1 2 Massachusetts Institute of Technology, Cambridge, MA, École Polytechnique Fédérale de Lausanne, Lausanne, 3 Switzerland, Massachusetts Institute of Technology and Howard Hughes Medical Institute, Cambridge, MA 2:15PM Selective Enhancement of Macropinocytosis For The Delivery Of a Mitochondriotoxic Peptide To Non-Small Cell Lung Cancer (NSCLC) 1 1 R. Iglesias and P. Koria 1 University of South Florida, Tampa, FL 2:30PM Targeting of Atheroprone Vasculature for Diagnostic Imaging and Prophylactic Drug Delivery 1 1 1 1 1 1 L. Hofmeister , S. Lee , W. Chen , T. Giorgio , D. Harrison , and H-J. Sung 1 Vanderbilt University, Nashville, TN 2:45PM Soluble Epoxide Hydrolase Inhibitor for Nerve Regeneration: Delivery by a Synthetic Nerve Conduit. 1 1 1 2 3 1 C. Terry , J. Agarwal , Y. He , S. Heilshorn , C. Morisseau , and J. Shea 1 2 3 University of Utah, Salt Lake City, UT, Stanford University, Stanford, CA, UC Davis, Davis, CA BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 18 of 34 Track: Nano to Micro Technologies, Device Technologies and Biomedical Robotics - OP-Sat-2-11 - Room 008A Cells Tissues and Organs on Chip II Chairs: Shannon Weigum, Joseph Kinsella 1:30PM Inflammatory Cell Trafficking Dynamics Across the Blood-Brain Barrier on a Novel Fluidic Platform 1 2 1 1 2 1 3 C. Palmiotti , R. Beard , A. Conway , F. Sinatra , S. Yuan , S. Sundaram , and A. Achyuta 1 2 Draper Laboratory, Tampa, FL, Dept. of Molecular Pharmacology & Physiology, Morsani College of Medicine, 3 University of South Florida, Tampa, FL, Draper Laboratory, Cambridge, MA 1:45PM Body-on-a-Chip Simulation with Gastrointestinal Tract and Liver Tissues Suggests that Ingested Nanonanoparticles Have the Potential to Cause Liver Injury 1 2 1 1 M. Esch , G. Mahler , T. Stokol , and M. Shuler 1 2 Cornell University, Ithaca, NY, Binghamton University, Binghamton, NY 2:00PM A Microfluidic Vascular Injury Model Using Heat-induced Endothelial Cell Activation 1 2 1 1,3 J. Sylman , S. Retterer , K. Rana , and K. Neeves 1 2 3 Colorado School of Mines, Golden, CO, Oak Ridge National Laboratory, Oak Ridge, TN, University of Colorado Denver, Denver, CO 2:15PM Digital Microfluidic Immunocytochemistry in Single Cells (DISC) for Analysis of Cell Signaling 1 1 1 A. H. C. Ng , M. D. Chamberlain , and A. R. Wheeler 1 University of Toronto, Toronto, ON, Canada 2:30PM Microfluidic Reconstruction of 3D Osteocyte Network and Mechanotransduction Function 1 1 1 2 1 1 Y. Gu , Q. Sun , W. Zhang , J. Zilberberg , A. Valdevit , and W. Lee 1 2 Stevens Institute of Technology, Hoboken, NJ, Hackensack University Medical Center, Hackensack, NJ 2:45PM A Microfluidic Platform For Dopaminergic Neuron Growth And In-Line Dopamine Uptake Measurements 1 1 1 1 Y. Yu , M. Shamsi , D. Krastev , and A. Wheeler 1 University of Toronto, Toronto, ON, Canada Track: Respiratory Bioengineering, New Frontiers and Special Topics - OP-Sat-2-12 - Room 008B Translational Respiratory Engineering Chairs: Joseph Bull, William Federspiel 1:30PM Respiratory Devices – “Bench to Bedside” 1 P. DeComo 1 ALung Technologies, Inc., Pittsburgh, PA 1:45PM An Acoustic Method for Detecting Air Flow in Artificial Airways 1 2,3 4 4 K. Yang , A. Muelenaer , A. Wicks , and T. Ruscher 1 2 1 Burton Center for Arts and Technology- Center for Engineering, Salem, VA, Carilion Clinic Children's Hospital, 3 4 Roanoke, VA, Virginia Tech Carilion School of Medicine, Roanoke, VA, Virginia Tech, Blacksburg, VA 2:00PM In Vitro Performance Of A Compact Integrated Blood Pump-Oxygenator For Ambulatory Respiratory Assist 1 1 1 1 S. Madhani , B. Frankowski , C. Bermudez , and W. Federspiel 1 University of Pittsburgh, Pittsburgh, PA 2:15PM Microtopographies LIMIT Bacterial Biofilm Accumulation: A Novel Approach to Decreasing Ventilator-Associated Pneumonia CASES 1 1 1 2 1 E. Mann , R. May , R. Mettetal , A. Brennan , and S. Reddy 1 2 Sharklet Technologies, Inc, Aurora, CO, University of Florida, Gainesville, FL BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 19 of 34 2:30PM Modeling A Novel Design For A Total Artificial Lung With Enhanced Flow Mixing 1 1 1 1 P. Fernando , H. Cheriyan , J. Bull , and R. Bartlett 1 University of Michigan, Ann Arbor, MI 2:45PM Personalized Predictions of Recruitment, Derecruitment, and Tissue Distention in the Injured Lung 1 1 2 2 2 2 3 4 4 B. Smith , L. Lundblad , J. Satalin , M. Kollisch-Singule , B. Emr , K. Snyder , L. Gatto , P. Andrews , N. Habashi , G. 2 1 Nieman , and J. Bates 1 2 3 University of Vermont, Burlington, VT, SUNY Upstate Medical University, Syracuse, NY, SUNY Cortland, Cortland, NY, 4 University of Maryland, Baltimore, MD Track: Device Technologies and Biomedical Robotics, Translational Biomedical Engineering - OP-Sat-2-13 - Room 201 Biosensors II: Applications Chairs: Sihong Wang, Lissett Bickford 1:30PM Multimarker Diabetes Management Device 1,2 2 J. La Belle and C. Cook 1 2 Arizona State University, Tempe, AZ, Mayo Clinic College of Medicine, Scottsdale, AZ 1:45PM Colorimetric Detection of Substrate Binding to Cytochome P450 with Plasmonic Nano Lycurgus Cup Array 1 1 1 1 1 1 1 L. Plucinski , A. Hsiao , M. Gartia , W. Arnold , A. Ameen , A. Das , and G. Liu 1 University of Illinois at Urbana-Champaign, Urbana, IL 2:00PM Rapid And No-wash Detection Of Avianin Fluenza A Virus From Clinical Swab Samples 1 1 1 1 1 C. Cheng , H. Cui , Q. Yuan , J. Wu , and S. Eda 1 The University of Tennessee, Knoxville, TN 2:15PM A Focused Surface Acoustic Wave Device for Rapid and Sensitive Detection of Listeria Monocytogenes Based on Recombinase Polymerase Amplification 1 1 1 1 1 1 L. Ren , F. Guo , Y. Chen , P. Li , Y. Xie , and T. Huang 1 Penn state university, State College, PA 2:30PM Multi-Modal System For Monitoring Cellular Behavior 1 1 1 1 1 1 L. Wong , C. Manjunath , M. Perez , C. Horner , M. Maldonado , and J. Nam 1 University of California, Riverside, Riverside, CA 2:45PM Multi-Electrode Sensing for Signal-to-Noise Ratio Enhancement of Impedance Cytometry 1 1 1 1 S. Emaminejad , S. Talebi , R. Davis , and M. Javanmard 1 Stanford University, Stanford, CA Track: Drug Delivery, Cancer Technologies - OP-Sat-2-14 - Room 103B Cancer Drug Delivery II Chairs: Beata Chertok, Emily Day 1:30PM Hydrophobically Modified Glycol Chitosan Nanoparticles: Enzymatic Stability, pH Responsiveness, Biocompatibility and Uptake 1 2 1 G. Suarato , A. Chin , and Y. Meng 1 2 Stony Brook University, Stony Brook, NY, Rensselaer Polytechnic Institute, Troy, NY 1:45PM Unnatural Killer Cells: TRAIL-coated Leukocytes Kill Cancer Cells in a Spontaneous Metastasis Mouse Model of Prostate Cancer 1 1 1 1 M. Mitchell , E. Wayne , C. Schaffer , and M. King 1 Cornell University, Ithaca, NY BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 20 of 34 2:00PM Nanotechnology Strategies to Improve Therapeutic Relevancy of Cisplatin for Malignant Gliomas 1 1 1 1 1 1 1 C. Zhang , E. Nance , P. Mastorakos , J. Chisholm , S. Berry , J. Suk , and J. Hanes 1 Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 2:15PM Polyanionic Nanoscale Hydrogels for the Oral Delivery of Chemotherapeutics 1 1 1 1 1 A. Puranik , D. Spencer , V. White , L. Pao , and N. Peppas 1 The University of Texas at Austin, Austin, TX 2:30PM Non-viral DNA Delivery to Human Adipose Mesenchymal Stem Cells for Glioblastoma Treatment 1 1 1 2 2 2 2 3 A. Denduluri , S. Tzeng , K. Kozielski , O. Wijesekera , A. Mangraviti , K. Chaichana , H. Guerrero-Cazares , J. Green , 2 and A. Quinones-Hinojosa 1 2 Dept. of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, Dept. of Neurosurgery, Johns Hopkins 3 University, Baltimore, MD, Dept. of Biomedical Engineering & Dept. of Neurosurgery, Johns Hopkins University, Baltimore, MD 2:45PM Biological Response To Multiple Administrations Of Viral Nanoparticles Carriers: Implication For Long-Term Drug Delivery Applications 1 1 1 1 1 1 S. Shukla , D. Dorand , J. Myers , J. Whitney , A. Huang , and N. Steinmetz 1 Case Western Reserve University, Cleveland, OH Track: Neural Engineering - OP-Sat-2-15 - Room 202A Glial Cell Engineering / Neural Progenitor Cell and Tissue Engineering Chairs: Deanna Thompson, Ryan Gilbert 1:30PM Schwann Cells and Electrical Stimulation: Enhanced Migration and Neurotrophic Factors to Aid PNS Repair 1 1 1 1 L. Zhang , A. Koppes , K. Kearns , and D. Thompson 1 Rensselaer Polytechnic Institute, Troy, NY 1:45PM Piezoelectric Fibrous Scaffolds for Schwann Cell Induced Spinal Cord Repair 1 2 2 1 2 Y-S. Lee , S. Damarju , S. Wu , M. Bunge , and T. Arinzeh 1 2 University of Miami, Miami, FL, New jersey Institute of Technology, Newark, NJ 2:00PM Aligned, Electrospun Fibers as Artificial Axons to Study Oligodendrocyte Myelination 1 2 3 1 1 2,3 S. Lee , S. Tuck , M. Leach , S. Chong , J. Chan , and J. Corey 1 2 3 University of California at San Francisco, San Francisco, CA, VA Ann Arbor Healthcare Center, Ann Arbor, MI, The University of Michigan, Ann Arbor, MI 2:15PM Three-Dimensional Microscaffolds for Enrichment and Transplantation of Human Pluripotent Stem Cell-Derived Neurons 1 1 1 1,2 2 1 N. Francis , N. Bennett , A. Carlson , A. Halikere , Z. Pang , and P. Moghe 1 2 Rutgers University, Piscataway, NJ, Child Health Institute of New Jersey, New Brunswick, NJ 2:30PM A Novel Injectable Hydrogel-Based Drug Delivery System for Local Delivery of T3 to Promote Myelination after Spinal Cord Injury 1 1 R. Shultz and Y. Zhong 1 Drexel University, Philadelphia, PA 2:45PM Engineering a White Matter Model of Traumatic Brain Injury 1 1 1 2 B. Pfister , A. Adams , J. Zalk , and H. Kim 1 2 New Jersey Institute of Technology, Newark, NJ, Rutgers University, Newark, NJ BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 21 of 34 Track: New Frontiers and Special Topics, Device Technologies and Biomedical Robotics - OP-Sat-2-16 - Room 202B Global Health II Chairs: Elain Fu, Anand Ramasubramanian 1:30PM Colorimetric Detection of Azidothymidine Using an Alkyne-Modified Dextran Substrate 1 1 1 G. Pratt , A. Fan , and C. Klapperich 1 Boston University, Boston, MA 1:45PM Conversion of a Laboratory-based Colorimetric Assay to a Field-use Paper-based Test for the Detection of Phenylketonuria in Newborns 1 1 1 2 G. Thiessen , K. De Los Reyes , R. Monnat , and E. Fu 1 2 University of Washington, Seattle, WA, Oregon State University, Corvallis, OR 2:00PM Quantitative Real-Time Recombinase Polymerase Amplification of HIV-1 DNA 1 1 1 B. Rohrman , Z. Crannell , and R. Richards-Kortum 1 Rice University, Houston, TX 2:15PM Real-time Fluorescence Detection of Nucleic Acid Amplification on a Mobile Phone for TB Diagnosis 1 2 3 3 1 A. Skandarajah , B. Baker , M. Kato-Maeda , A. Cattamanchi , and D. Fletcher 1 2 3 University of California, Berkeley, Berkeley, CA, Lawrence Livermore National Laboratory, Livermore, CA, UCSF Medical School, San Francisco, CA 2:30PM Fluorescence Detection of DNA Amplification in Porous Media for Point-of-Care Diagnostics 1 1 1 C. Monahan , J. Bishop , and P. Yager 1 University of Washington, Seattle, WA 2:45PM A Fully Integrated Paper-Based Assay for the Extraction, Isothermal Amplification, and Detection of Pandemic (H1N1) Influenza A RNA 1,2 1 1 1,2 1 N. Rodriguez , A. Fan , J. Linnes , C. Chen , and C. Klapperich 1 2 Boston University, Boston, MA, Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA Track: Biomedical Imaging and Optics - OP-Sat-2-17 - Room 203A Novel Approaches to Biomedical Imaging Chairs: B. Hyle Park, Nozomi Nishimura 1:30PM Multi-parametric Photoacoustic Microscopy of Arterial Ligation 1 1 1 2 2 2 1 1 M. Kennedy , B. Ning , S. Seaman , R. Chen , Q. Zhou , K. Shung , S. Peirce , and S. Hu 1 2 University of Virginia, Department of Biomedical Engineering, Charlottesville, VA, University of Southern California, Resource Center for Medical Ultrasonic Transducer Technology, Los Angeles, CA 1:45PM Diagnostic Accuracy of Integrated Intravascular Ultrasound and Optical Coherence Tomography for the Detection and Characterization of Human Atherosclerotic Plaque 1 2 1 2 2 1 2 1 T. Ma , J. Li , A. Correa , D. Mohar , P. Patel , K. Shung , Z. Chen , and Q. Zhou 1 2 University of Southern California, Los Angeles, CA, University of California, Irvine, Irvine, CA 2:00PM Multi-Modal Validation Framework of Mitral Valve Geometry and Biomechanical Models 1 2 1 1 2 2 2 2 1 3 S. Grbic , T. Easley , T. Mansi , D. Neumann , E. Pierce , M. Jensen , C. Bloodworth , A. Siefert , J. Krebs , D. Yuh , A. 2 1 Yoganathan , and D. Comaniciu 1 2 3 Siemens, Princeton, NJ, Georgia Tech, Atlanta, GA, Yale University School of Medicine, New Haven, CO BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 22 of 34 2:15PM Rapid Throughput, Seamless Imaging of Human Hip Joint Tissue Across Length Scales to Elucidate Emergent Structure-Function Relationships 1 2 1 1 3 D. Zeidler , U. Knothe , T. Garbowski , G. Dellemann , and M. Knothe Tate 1 2 3 Carl Zeiss Microscopy, Oberkochen, Germany, Cleveland Clinic, Cleveland, OH, University of New South Wales, UNSW Sydney, Australia 2:30PM Quantitative Measurement of Cerebrospinal Fluid Flow in Ventricular Shunts by Contrast-enhanced Ultrasound and Cross-correlation Based Microbubble Tracking 1 1 2 1 R. Hartman , S. Aglyamov , D. Fox , and S. Emelianov 1 2 University of Texas at Austin, Austin, TX, St. David's NeuroTexas Institute, Austin, TX 2:45PM Novel Dental Imaging System 1 1 1 2 J. Johnson , S. Gray , L. Leonard , and R. Weber 1 2 UTSI, Tullahoma, TN, MDI, Arlington Heights, IL Track: Biomedical Imaging and Optics - OP-Sat-2-18 - Room 203B Optical Imaging and Microscopy II Chairs: Javier Jo, Michael Fenn 1:30PM Bioengineering Autobioluminescence for Biomedical Imaging: From Microbe to Man 1 2 2 1 S. Ripp , T. Xu , D. Close , and G. Sayler 1 2 The University of Tennessee, Knoxville, TN, 490 BioTech Inc., Knoxville, TN 1:45PM Live-Cell Analysis of Fibroblast Phenotype on Electrospun Meshes using Surface Enhanced Raman Spectroscopy 1 1 1 1 E. Kibrom , N. Roki , C. Bashur , and M. Fenn 1 Florida Institute of Technology, Melbourne, FL 2:00PM Optimization of Time Gate Selection in Bi-exponential Fluorescence Lifetime Imaging via Sensitivity Analysis 1 1 1 1 1 T. Omer , N. Sinsuebphon , L. Zhao , X. Intes , and J. Hahn 1 Rensselaer Polytechnic Institute, Troy, NY 2:15PM Multiplexing Imaging of Single mRNA Isoforms for Dynamical Quantification in Live Cells 1,2 2 1 2 K. Lee , Y. Cui , L. Lee , and J. Irudayaraj 1 2 University of California Berkeley, Berkeley, CA, Purdue University, West Lafayette, IN 2:30PM Confocal Fluorescence Nanocytology: Detecting The Molecular Mechanisms Of Carcinogenesis 1 1 1 1 1 1 J. Chandler , Y. Stypula-Cyrus , L. Almassalha , B. Frese , H. Subramanian , and V. Backman 1 Nortwestern University, Evanston, IL 2:45PM Predictive Model Of Probe-Dependent Sampling Depth In Diffuse Reflectance Spectroscopy 1 1 1 1 W. Goth , R. Hennessy , M. Sharma , and J. Tunnell 1 The University of Texas at Austin, Austin, TX Track: Cancer Technologies, Nano to Micro Technologies - OP-Sat-2-19 - Room 103A Nanotechnologies for Cancer II Chairs: Kaiming Ye, Debadyuti (Rana) Ghosh 1:30PM Tumor-penetrating Nanocomplexes for siRNA Delivery to Pancreatic Cancer 1,2 1 1,3 1,2 1 1,4,5 J. Lo , E. Kwon , M. Muzumdar , Y. Ren , T. Jacks , and S. Bhatia 1 2 3 MIT, Cambridge, MA, Harvard-MIT MD-PhD program, Boston, MA, Dana-Farber Cancer Institute, Boston, MA, 4 5 Brigham and Women's Hospital, Boston, MA, Broad Institute of Harvard and MIT, Cambridge, MA BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 23 of 34 1:45PM Spherical Nucleic Acids as an RNAi-Based Therapy for Glioblastoma 1,2 2 2 2 2 2 E. Day , S. Jensen , C. Ko , L. Hurley , A. Stegh , and C. Mirkin 1 2 University of Delaware, Newark, DE, Northwestern University, Evanston, IL 2:00PM Magnetic Fluid Hyperthermia Increases Bortezomib Cytotoxicity in Cancer Cells by Proteotoxic Stress 1 2 2 2 3 M. Torres-Lugo , M. Alvarez , A. Castillo , O. Soto , and C. Rinaldi 1 2 University of Puerto Rico, Mayaguez Campus, Mayaguez, Puerto Rico, University of Puerto Rico, Mayaguez Campus, 3 Mayaguez, PR, Puerto Rico, University of Florida, Gainesville, Gainesville, FL 2:15PM Prussian Blue Nanoparticles For Laser-Induced Photothermal Therapy Of Tumors 1 1 1 1,2 1,2 H. Hoffman , L. Chakrabarti , M. Dumont , A. Sandler , and R. Fernandes 1 2 Children's National Health System, Washington, DC, George Washington University, Washington, DC 2:30PM Synergistic Antitumor Activity from Two-Stage Delivery of Piperlongumine and TRAIL Nanoparticles 1 1 1 C. Sharkey , J. Li , and M. King 1 Cornell University, Ithaca, NY 2:45PM A Nano-plasmonic Sensor for Label-free Detection and Molecular Profiling of Cancer Exosomes 1 1 1 1 1 1,2 1 H. Im , H. Shao , Y. Park , V. Peterson , C. Castro , R. Weissleder , and H. Lee 1 2 Massachusetts General Hospital, Boston, MA, Harvard Medical School, Boston, MA Track: Undergraduate - OP-Sat-2-20 - Room 204B Undergraduate Research I Chairs: William Guilford, Kristine Ropella 1:30PM Computational Prediction of G-quadruplex Formation 1 1 1 1 J. Calvert , A. Kreig , S. Sinha , and S. Myong 1 University of Illinois at Urbana-Champaign, Champaign, IL 1:40PM Spatiotemporal-Specific Antibody Signatures Associated with Tenofovir Microbicide Use 1 2 1 3 2,4,5 2 4 3 L. Dunphy , D. Archary , K. Arnold , K. Seaton , J-A. Passmore , L. Werner , L. Morris , G. Tomaras , and D. 1 Lauffenburger 1 2 Massachusetts Institute of Technology, Cambridge, MA, Centre for the AIDS Programme of Research in South Africa 3 (CAPRISA), Durban, South Africa, Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, 4 5 National Health Laboratory Services, Johannesburg, South Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa 1:50PM Bioactive Glass Ceramics: The Ideal Synthetic Bone Substitute 1 1 1 E. Mason , M. Fenn , and L. Hench 1 Florida Institute of Technology, Melbourne, FL 2:00PM Zeolite-loaded Alginate-chitosan Hydrogel Beads As A Topical Hemostat 1 1 1 1 1 1 1 1 1 K. Christodoulides , M. Bayomi , Y. Choi , P. Fathi , A. Ghodasara , J. Knazik , K. Langan , B. Miller , M. Sikorski , H. 1 1 1 1 1 Thaker , J. Titcomb , O. Wonodi , A. Behrens , and P. Kofinas 1 University of Maryland, College Park, MD 2:10PM Evaluation of Screw-Tunnel Divergence and Graft Fixation Biomechanics using Flexible and rigid Reamer Systems for Anterior Cruciate Ligament Reconstruction 1,2 1,3 1 1,3 1,4 1,5 1,3 1,3 M. Drazek , K. Walley , M. Perez-Viloria , S. Okajima , O. Manoukian , A. Masoudi , A. Chiloyan , R. Nair , M. 6 1 Steiner , and A. Nazarian 1 2 3 Beth Israel Deaconess Medical Center, Boston, MA, Tufts University School of Medicine, Boston, MA, Boston 4 5 6 University, Boston, MA, University of Connecticut, Storrs, CT, Harvard Medical School, Boston, MA, New England Baptist Hospital, Roxbury Crossing, MA BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 24 of 34 2:20PM Mechanical Activity of Valve Interstitial Cells in Disease-like Conditions 1 1 2 1 1 V. Pramil , E. Farrar , C. Mosher , J. Richards , and J. Butcher 1 2 Cornell University, Ithaca, NY, Case Western University, Cleveland, OH 2:30PM Imaging Collagen Architecture With Polarization-Sensitive Optical Coherence Tomography 1 2,3,4 2,3,4 2,3,4 R. De La Rosa , M. Villiger , N. Uribe-Patarroyo , and B. Bouma 1 2 3 Brown University, Providence, RI, Wellman Center for Photomedicine, Boston, MA, Harvard Medical School, 4 Boston, MA, Massachusetts General Hospital, Boston, MA 2:40PM Ultrasound Imaging of Forearm Muscles for Decoding Hand Movements in Real Time 1 1 1 1 M. Lahlou , N. Akhlaghi , H. Zafar , and S. Sikdar 1 George Mason Univiersity, Fairfax, VA 2:50PM Using Nonlinear Dynamical Measures to Compare MEG Recordings of Epilepsy Patients with Normal Controls 1 2 2 2 S. Subramanian , S. Robinson , S. Inati , and R. Coppola 1 2 Johns Hopkins University, Baltimore, MD, National Institutes of Health, Bethesda, MD BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 25 of 34 SATURDAY, October 25, 2014 - 3:15 PM - 4:45 PM PLATFORM SESSIONS – Sat - 3 Track: Tissue Engineering, Orthopaedic and Rehabilitation Engineering - OP-Sat-3-1 - Room 001A Muscular, Tendinous, Ligamental Tissue Engineering Chairs: George Christ, Vassilios Sikavitsas 3:15PM Highly Functional Engineered Skeletal Muscle Tissues: From Rat to Human 1 N. Bursac 1 Duke University, Durham, NC 3:30PM Mechanical Stimulation of Cellularized Polyurethane-Collagen Composite Meshes for Connective Tissue Applications 1 1 1 2 1 P. Thayer , E. Tong , L. Dahlgren , S. Guelcher , and A. Goldstein 1 2 Virginia Tech, Blacksburg, VA, Vanderbilt University, Nashville, TN 3:45PM Keratin Hydrogels as a Cell and Growth Factor Delivery Vehicle for Treatment of Volumetric Muscle Loss 1,2 1 3 1 1,2 4 3 3 H. Baker , J. Passipieri , S. Tomblyn , M. Siriwardane , C. Okoukoni , C. Stewart , M. Ellenburg , L. Burnett , and G. 1,2 Christ 1 2 Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, VT-WFU School of Biomedical Engineering and 3 4 Sciences, Winston Salem, NC, KeraNetics, LLC, Winston Salem, NC, University of Virginia, Charlottesville, VA 4:00PM Tendon Tissue Engineering using a Mechanostimulator and Adult Stem Cell Seeded Decellularized Human Umbilical Vein 1 1 V. Sikavitsas and B. Engebretson 1 University of Oklahoma, Norman, OK 4:15PM Contractile Composite Scaffolds for Skeletal Muscle Tissue Engineering 1 1 1 1 D. Browe , C. Simmonds , K. McKeon-Fischer , and J. Freeman 1 Rutgers University, Piscataway, NJ 4:30PM Localized BMP-4 Release For Improvement of the Engineered Enthesis 1 1 1 1 A. Lee , C. Lee , M. Vidal , and K. Baar 1 University of California, Davis, Davis, CA Track: Biomaterials, Cellular and Molecular Bioengineering - OP- Sat - 3-2 - Room 001B Biomaterials for Immunoengineering II Chairs: Lindsay Fitzpatrick, Anjelica Gonzalez 3:15PM Immunomodulatory Scaffolds for Enhanced Cell Transplant 1 1 1 1 1 1 R. Gower , X. Zhang , J. Zhang , J. Liu , C. Ricci , and L. Shea 1 Northwestern University, Chicago, IL 3:30PM Biodegradable Nanoellipsoidal Artificial Antigen Presenting Cells for Cancer Immunotherapy 1 1 1 1 1 1 R. Meyer , J. Sunshine , K. Perica , K. Aje , J. Schneck , and J. Green 1 School of Medicine, Johns Hopkins University, Baltimore, MD 3:45PM Incorporation of The Extra Domain A of Fibronectin (EDA) in Fibrin Matrices Mediates Activation of DCs and T-celldependent Tumor Regression 1 1 1 1 Z. Julier , M. Martino , A. de Titta , and J. Hubbell 1 Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 26 of 34 4:00PM Effects of Age-Related Changes in Biomechanical and Biochemical Properties Upon Host Response to ECM 1,2 1,2 1 1,2 S. LoPresti , L. Zhang , C. Dearth , and B. Brown 1 2 University of Pittsburgh, Pittsburgh, PA, McGowan Institute for Regenerative Medicine, Pittsburgh, PA 4:15PM Injectable Thermogelling Block Copolymers as Vaccine Delivery Devices 1 1 J. Adams and S. Mallapragada 1 Iowa State University, Ames, IA 4:30PM Modulation of Cardiac Macrophages via Hydrogel-mediated IL-4 Delivery as a Strategy for Infarct Healing 1 1 2 1 1 1,2 I. Somasuntharam , S. Carroll , M. Brown , A. Salimath , A. Garcia , and M. Davis 1 2 Georgia Institute of Technology, Atlanta, GA, Emory University, Atlanta, GA Track: Biomaterials - OP-Sat-3-3 - Room 006A Biomaterials Design II Chairs: Nasim Annabi, Michael Davis 3:15PM Near-infrared Light Triggerable Polysaccharides Double Network Hydrogel 1 1 2 2 1 R. Luo , Z. Lim , W. Li , P. Shi , and C-H. Chen 1 2 National University of Singapore, Singapore, Singapore, City University of Hong Kong, Hong Kong, Hong Kong 3:30PM The Design of Hypoxia-Inducible Hydrogels via In Situ Oxygen Consuming Reaction 1 1 K. Park and S. Gerecht 1 Johns Hopkins University, Baltimore, MD 3:45PM Hierarchical Design of Tunable Tissue-Like Collagen Materials 1 1 1 1 K. Blum , T. Novak , C. Neu , and S. Voytik-Harbin 1 Purdue University, West Lafayette, IN 4:00PM Superbiocompatible Hydrogels for Islet Encapsulation Therapy: Tuning the Geometry of Hydrogels Prevents Foreign Body Immune Responses and Fibrosis to Enable Long-Term Blood Glucose Correction in Diabetic Mice 1 1 1 1 1 O. Veiseh , J. Doloff , A. Vegas , R. Langer , and D. Anderson 1 Massachusetts Institute of Technology, Cambridge, MA 4:15PM Directing Cell Functions Using Bioorthogonally Clicked Multiblock Hybrid Copolymers 1 1 1 1 S. Liu , H. Zhang , J. Fox , and X. Jia 1 University of Delaware, Newark, DE Track: Biomechanics - OP-Sat-3-4 - Room 006B Biomechanics in Degeneration and Regeneration Chairs: Alesha Castillo, Kyle Allen 3:15PM A Novel Biomechanical Model to Study Subchondral Microdamage Following Acute Knee Injury 1 1 1 O. Kennedy , B. Beutel , and M. Lendhey 1 New York University School of Medicine, NY, NY 3:30PM Prevention of Cartilage Degeneration by Intraarticular Treatment with Lubricin-Mimetics in the Rat Following Anterior Cruciate Ligament Transection 1 1 2 2 2 2 2 1 1 K. Samaroo , M. Tan , M. Demange , A. Titan , C. Carballo , M. Sisto , S. Rodeo , D. Putnam , and L. Bonassar 1 2 Cornell University, Ithaca, NY, Hospital for Special Surgery, New York, NY BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 27 of 34 3:45PM Indentation Method to Map Mechanical Properties of Articular Surface to Identify Degenerated Regions 1,2 1 2 2 1 S. Sim , A. Chevrier , M. Garon , E. Quenneville , and M. Buschmann 1 2 Ecole Polytechnique de Montreal, Montreal, QC, Canada, Biomomentum Inc., Laval, QC, Canada 4:00PM Mechanobiology assessment of Temporomandibular Disc surfaces: A Nanoindentation and TEM study. 1 1 1 C. Juran , A. Matuska , and P. McFetridge 1 University of Florida, Gainesville, FL 4:15PM Genipin Effect on Soft Palates for the Treatment of Snoring and Obstructive Sleep Apnea 1 1 1,2 J. Kuo , P. Slusarewicz , and T. Hedman 1 2 Orthopeutics LP, Lexington, KY, University of Kentucky, Lexington, KY 4:30PM The Effect of IGF-I Gene Therapy on the Mechanical Properties of Repaired Equine Cartilage 1 1 1 1 D. Griffin , K. Ortved , A. Nixon , and L. Bonassar 1 Cornell University, Ithaca, NY Track: Biomechanics - OP-Sat-3-5 - Room 006C Multiscale Biomechanics Chairs: Heather Hayenga, Rouzbeh Amini 3:15PM A Multiscale Particle Based Model of Platelets in Shear Flows: Correlating Numerical Simulations with In Vitro Results 1 1 1 1 1 1 1 2 1 1 P. Zhang , J. Sheriff , C. Gao , M. Livelli , S. Pothapragada , N. Zhang , L. Zhang , M. Slepian , Y. Deng , and D. Bluestein 1 2 Stony Brook University, Stony Brook, NY, University of Arizona, Tucson, AZ 3:30PM How the Morphology of Osteocytes Contributes to their Mechanotransduction near Microdamage 1,2 3 1 3 3 1 E. Budyn , M. Bensidhoum , E. Henry , J-C. Auregan , H. Petite , and E. Deprez 1 2 3 Ecole Normale Superieure de Cachan, Cachan, France, University of Illinois at Chicago, Chicago, IL, University Paris Diderot, Paris, France 3:45PM Finite Element Modeling of Normal and Pathological Chinchilla Ears 1 1 1 1 1 X. Wang , X. Guan , R. Browder , D. McCaskill , and R. Gan 1 University of Oklahoma, Norman, OK 4:00PM Coarse-Grained Molecular Dynamics Modeling of Band-3 Protein Diffusion in the Defective Red Blood Cell Membrane 1 1 H. Li and G. Lykotrafitis 1 University of Connecticut, Storrs, CT 4:15PM Computational Analysis of Eustachian Tube Opening during Inflammatory Otitis Media in Children with Cleft Palate 1 1 J. Malik and S. Ghadiali 1 The Ohio State University, Columbus, OH 4:30PM A Computational-Experimental Approach for the In Situ Estimation of Aortic Valve Interstitial Cell Biophysical State 1 1 R. Buchanan and M. Sacks 1 The University of Texas at Austin, Austin, TX BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 28 of 34 Track: Cancer Technologies, Nano to Micro Technologies - OP-Sat-3-6 - Room 006D Microtechnologies for Cancer II Chairs: Sihong Wang, Wei Li 3:15PM Metastatic Cancer Cells Migration in 3D Collagen Matrix and Microtracks 1 1 1 1 1 1 A. Rahman , S. Carey , C. Kraning-Rush , B. Romero , R. Williams , and C. Reinhart-King 1 Cornell University, Ithaca, NY 3:30PM Decoupling Protrusion from Migration: A New Assay to Study Cancer Cell Protrusion Dynamics in the Absence of Migration 1 1 B. Koons and A. Nain 1 Virginia Tech, Blacksburg, VA 3:45PM Programmable Bacteria for Cancer Therapy and Diagnostics 1 2 2 1 1 2 T. Danino , A. Prindle , O. Din , G. Kwong , S. Bhatia , and J. Hasty 1 2 MIT, Cambridge, MA, UCSD, La Jolla, CA 4:00PM Epidermal Growth Factor as a New Migration-Targeted Therapy for Pediatric Brain Tumors 1 1 1 1 J. Rico , T. Singh , S. McCutcheon , and M. Vazquez 1 The City College of New York (CUNY), New York, NY 4:15PM A Kinetic Model for Rapid Molecular Phenotyping of Resected Tissues during Cancer Surgery 1 2 1 2 2 2 1 L. Sinha , Y. Wang , C. Yang , A. Khan , S. Leigh , J. Liu , and K. Tichauer 1 2 Illinois Institute of Technology, Chicago, IL, Stony Brook University (SUNY), Stony Brook, NY 4:30PM A Comparative Study Of Patient-Derived Primary Brain Tumor Cells Using 3D Biomimetic Hydrogels 1 1 1 1 1 1 1 1 C. Wang , X. Jiang , C. Wilson , A. Ponnuswami , V. Caretti , M. Monje , G. Grant , and F. Yang 1 Stanford University, Stanford, CA Track: Stem Cell Engineering, Tissue Engineering - OP-Sat-3-7 - Room 007A Stem Cells in Translational Science Chairs: Eduardo Silva, Stephanie Willerth 3:15PM Spatiotemporal Mapping of De Novo Tissue Genesis by Stem Cells & Tissue-Implant Interactions 1 2 3 1 4 1 C. Heu , S. Moore , U. Knothe , R. Segal , T. Piepergerdes , and M. Knothe Tate 1 2 3 University of New South Wales, UNSW Sydney, Australia, Case Western Reserve University, Cleveland, OH, Cleveland 4 Clinic, Cleveland, OH, Vanderbilt University, Nashville, TN 3:30PM Preparation of Native Extracellular Matrix for Stem Cell-based Salivary Gland Regeneration. 1 1 1 1 1 1 1 2 A. Malakhov , B-X. Zhang , H. Wang , A. Lin , D. Dean , S. Weintraub , X-D. Chen , and C-K. Yeh 1 2 UTHSC, San Antonio, TX, STVHCS, San Antonio, TX 3:45PM A Human iPS-derived In Vitro Model of 3D Vascularized Cardiac Muscle 1 1 1 1 1 1 1 1 1 2 Y. Kurokawa , D. Tran , M. Moya , A. Sobrino , L. Alonzo , C. Heylman , C. Tu , L. Lock , C. Hughes , B. Conklin , and S. 1 George 1 2 University of California, Irvine, Irvine, CA, Gladstone Institutes, San Francisco, CA 4:00PM Stable Human Induced Pluripotent Stem Cell-derived Cardiomyocyte Syncytium That Supports Paced Electrical Activities and Responds to IKr Blockage 1 1 1 1 R. Zhu , A. Blazeski , K. Boheler , and L. Tung 1 The Johns Hopkins University, Baltimore, MD BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 29 of 34 4:15PM Beat Whole Decellularized Mouse Heart with Human Induced Pluripotent Stem (iPS) Cells 1 1 1 1 1 1 1 B. Lin , T. Lu , J. Kim , M. Sullivian , K. Tobita , G. Salama , and L. Yang 1 University of Pittsburgh, Pittsburgh, PA Track: Cardiovascular Engineering - OP-Sat-3-8 - Room 007B Heart Valves and Stents II Chairs: Mehdi Nikkah, Gulden Camci-Unal 3:15PM Physiological Relevant Shear Stress and Flexure in Developing Valvular Tissues 1 1 1 1 S. Rath , A. Villegas , M. Salinas , and S. Ramaswamy 1 Florida International University, MIAMI, FL 3:30PM Design of an In Vitro Simulation Pipeline for the Development of Computational Mitral Valve Modeling 1 1 1 1 2 2 2 1 1 C. Bloodworth IV , E. Pierce , T. Easley , M. Toma , A. Khalighi , C-H. Lee , M. Sacks , A. Siefert , M. Jensen , and A. 1 Yoganathan 1 2 Georgia Institute of Technology, Atlanta, GA, University of Texas at Austin, Austin, TX 3:45PM Integrated Experimental-Computational Modeling of Mitral Valve Intestitial Cell Deformation Under In Situ Physiological Loading 1 2 3 1 4 4 1 C-H. Lee , C. Carruthers , B. Good , S. Ayoub , R. Gorman , J. Gorman , and M. Sacks 1 2 3 The University of Texas at Austin, Austin, TX, Metronic, Minneapolis, MN, Pennsylvania State University, State 4 College, PA, University of Pennsylvania, Philadelphia, PA 4:00PM Impact of Transcatheter Aortic Valve Oversizing on Leaflet Stress and Strain Distribution 1 1 M. Abbasi and A. Azadani 1 University of Denver, Denver, CO 4:15PM Hemodynamic Changes in Coronary Arteries Due to Regional Aortic Root Pathologies 1 2 1 H. Mohammadi , R. Cartier , and R. Mongrain 1 2 McGill University, Montreal, QC, Canada, Montreal Heart Institute, Montreal, QC, Canada 4:30PM Stent Strut Geometry Affects Endothelial Cell Migration 1 1 1 J. Jiménez , P-J. Wang , and P. Davies 1 University of Pennsylvania, Philadelphia, PA Track: Drug Delivery - OP-Sat-3-9 - Room 007D Targeted Delivery II Chairs: Michael Davis, Junghae Suh 3:15PM Targeting Drug Delivery to Motor Neurons in the Spinal Cord 1 1 R. Sirianni and A. Prakapenka 1 Barrow Neurological Institute, Phoenix, AZ 3:30PM Albumin Nanoparticles for Targeted EDTA Delivery to Reverse Elastin Specific Medial Calcification 1 1 Y. Lei and N. Vyavahare 1 Clemson University, Clemson, SC 3:45PM Cystathionine-Gamma-Lyase Enzyme Prodrug Therapy Targeted to Tumor Vasculature in Immune Competent Model 1 2 1 J. Krais , C. Kurkjian , and R. Harrison 1 2 University of Oklahoma, Norman, OK, University of Oklahoma Health Sciences Center, Oklahoma City, OK BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 30 of 34 4:00PM Protease-activatable Virus Based on Adeno-associated Virus for Cardiovascular Disease Therapy 1 1 1 1 1 M. Ho , M. Lam , M. Yamagami , C. Guenther , and J. Suh 1 Rice University, Houston, TX 4:15PM Development of Poly-aspartic Acid Peptide Linked PLGA-based Nanoparticles for Bone Targeting 1 1 1 1 1 1 E. Carbone , X. Yu , T. Jiang , C. Nelson , H. Kan , and W. Lo 1 UConn Health Center, Farmington, CT 4:30PM Plasma Proteins Alter the Vascular Wall Adhesion of Drug Carriers in a Material & Donor Specific Way 1 1 1 1 1 1 D. Sobcynski , P. Charoenphol , P. Onyskiw , K. Namdee , A. Thompson , and L. Eniola-Adefeso 1 University of Michigan, Ann Arbor, MI Track: Respiratory Bioengineering, Biomechanics - OP-Sat-3-10 - Room 008B Mechanobiology in the Respiratory System Chairs: Konstantin Birukov, Rebecca Heise 3:15PM Genetic Variants of Cytoskeletal Elements Linked to Acute Lung Injury Impair Lamellipodia Dynamics and Endothelial Wound Healing 1 1 2 D. Leckband , S. Choi , and S. Dudek 1 2 University of Illinois at Urbana, Urbana, IL, University of Illinois at Chicago, Chicago, IL 3:30PM The Role of MicroRNAs in Ventilator Induced Lung Injury (VILI) and Inflammation 1 1 1,2 1,3 K. Nelson , C. Bobba , B. Whitson , and S. Ghadiali 1 2 Ohio State University, Columbus, OH, Department of Surgery and Division of Cardiac Surgery, Columbus, OH, 3 Department of Pulmonary, Allergy, Critical Care, and Sleep, Columbus, OH 3:45PM Paxillin-GEF-H1-MAPK Signalosome and Pathologic Mechanotransduction in Mechanically Ventilated Lung 1 1 1 1 G. Gawlak , X. Tian , A. Birukova , and K. Birukov 1 University of Chicago, Chicago, IL 4:00PM Enhanced Matrix Elastin Production and Organization Using Pentagalloyl Glucose in Pulmonary Fibroblast Cultures 1 1 1 V. Parasaram , N. Nosoudi , and N. Vyavahare 1 Clemson University, Clemson, SC 4:15PM Chronic Tone and Substrate Stiffness Modulation Alters Airway Smooth Muscle Contractile Phenotype 1 1 2 1 3 1 R. Wise , N. Zaman , A. West , P. Gratzer , K. Billiar , and G. Maksym 1 2 3 Dalhousie University, Halifax, NS, Canada, University of Manitoba, Winnipeg, MB, Canada, Worcester Polytechnic Institute, Worcester, MA 4:30PM Age Related Changes in Pulmonary Mechanics and Inflammatory Response to Experimental Ventilator Induced Lung Injury 1 1 1 1 2 1 J. Herbert , M. Valentine , P. Patel , A. Reynolds , R. Pidaparti , and R. Heise 1 2 Virginia Commonwealth University, Richmond, VA, University of Georgia, Athens, GA Track: Neural Engineering, Orthopaedic and Rehabilitation Engineering - OP-Sat-3-11 - Room 201 Neuro-rehabilitation Biomechanics Chairs: Jeffrey Capadona, Ayesgul Gunduz 3:15PM Predicting Metabolic Costs of Pathologic Gait in Cerebral Palsy 1 2,3 K. Steele and M. Schwartz 1 2 3 University of Washington, Seattle, WA, Gillette Children's Specialty Healthcare, St. Paul, MN, University of Minnesota, Minneapolis, MN BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 31 of 34 3:30PM Information Theoretic Metrics as Biomarkers of Parkinsonian Symptom Severity 1 1 C. Anderson and A. Dorval 1 University of Utah, Salt Lake City, UT 3:45PM Increased Shoulder Abduction Loads Decrease Voluntary Finger Flexion in Individuals with Chronic Stroke 1 1 1 Y. Lan , J. Yao , and J. Dewald 1 Northwestern University, CHICAGO, IL 4:00PM Dynamic Simulation and Neuromuscular Control of Balance in Children with Cerebral Palsy: Implications for Rectus Femoris Transfer Surgery 1 1 M. Mansouri Boroujeni and J. Reinbolt 1 University of Tennessee, Knoxville, TN 4:15PM Optimizing the Spinal Cord: Finding the Best Sensory Input to Improve Walking after Injury 1,2 3 2,4 1,2 J. White , L. McCollough , K. Tansey , and S. DeWeerth 1 2 3 4 Georgia Institute of Technology, Atlanta, GA, Emory University, Atlanta, GA, Shepherd Center, Atlanta, GA, Atlanta VA Medical Center, Atlanta, GA 4:30PM An Analytical Solution For Obtaining The Lumbar Spine Segmental Rotations 1 1 I. Shojaei and B. Bazrgari 1 University of Kentucky, Lexington, KY Track: Drug Delivery, Cancer Technologies - OP-Sat-3-12 - Room 103B Cancer Drug Delivery III Chairs: Srivatsan Kidambi, Joseph Kinsella 3:15PM Targeted Polymeric Nanoparticles for Leukemia Cell-Specific Delivery of Pediatric Chemotherapy 1,2 3 2 1 1 V. Krishnan , X. Xu , R. W. Mason , X. Jia , and A. K. Rajasekaran 1 2 3 University of Delaware, Newark, DE, Nemours Alfred I DuPont Hospital for Children, Wilmington, DE, Massachusetts Institute of Technology, Cambridge, MA 3:30PM Functionalization of Gold Nanorods for Cancer Cell Imaging, Drug Delivery and Photothermal Therapy 1 2 1 1 1 2 1 1 D. Pacardo , B. Neupane , M. Rikard , Y. Lu , R. Mo , G. Wang , F. Ligler , and Z. Gu 1 2 North Carolina State University and University of North Carolina, Raleigh, NC, North Carolina State University, Raleigh, NC 3:45PM Novel Functionalization of Single Walled Carbon Nanohorns for Controlled Chemotherapeutic Delivery 1 1 1 A. Pekkanen , M. DeWitt , and M. Rylander 1 Virginia Tech, Blacksburg, VA 4:00PM A Magnetic Field to Target Paramagnetic Nanoparticles in a Tumor Model of Glioblastoma 1 1 1 1 1 1 1 M. Navati , S. Lopez , M. Urban-Maldonado , M. Silva , J. Segall , D. Spray , and J. Friedman 1 Yeshiva University, Bronx, NY 4:15PM Oxidized Graphene Nanoribbons As A Novel Delivery System For The Anticancer Sphingolipid Ceramide 1 1 1 C. Suhrland , B. Sitharaman , and J-P. Truman 1 SUNY Stony Brook, Stony Brook, NY 4:30PM Thermo-responsive, Multimodal Imaging Enabled Nanoparticles Towards Cancer Therapy 1 1 1,2 2 2 1,2 3 1,2 N. Pandey , A. Wadajkar , V. Sundaresan , E. Hernandez , J-T. Hsieh , L. Tang , J. Yang , and K. Nguyen 1 2 3 University of Texas at Arlington, Arlington, TX, The University of Texas Southwestern Medical Center, Dallas, TX, The Pennsylvania State University, University Park, PA BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 32 of 34 Track: Neural Engineering, Biomedical Imaging and Optics - OP-Sat-3-13 - Room 202A Macro/micro Design for Neurotechnologies / Networked Neural Sensors, Actuators, and Instrumentation Chairs: Pedro Irazoqui, Mehmet Kaya 3:15PM Implantable Networks of Wireless Nanoelectronic Nodes 1 P. Irazoqui 1 Purdue University, West Lafayette, IN 3:30PM System for Integrated Neural Imaging, Recording and Stimulation 1 2 Z. Liu and H. Cheng 1 2 Purdue University, West Lafayette, IN, Indiana University, Bloomington, IN 3:45PM Ultrasound Neuromodulation: Field Overview and Observations in the Vagus Nerve of a Rat 1 E. Juan 1 UPR-Mayagüez, Mayagüez, PR 4:00PM Nanowire Electrophysiology for in vivo Measurement of the C. elegans Neuromuscular Junction 1 1 1 1,2 D. Gonzales , B. Avants , D. Vercosa , and J. Robinson 1 2 Rice University, Houston, TX, Baylor College of Medicine, Houston, TX 4:15PM The Multipatcher: A Robot for High Density Measurement of Intracellular Recordings In Vivo 1 1,2 3 1 1,2 3 1 S. Kodandaramaiah , F. Flores , G. Holst , I. Wickersham , E. Brown , C. Forest , and E. Boyden 1 2 3 Massachusetts Institute of Technology, Cambridge, MA, Massachusetts General Hospital, Cambridge, MA, Georgia Institute of Technology, Atlanta, GA 4:30PM Principles of High Fidelity, High Density 3D Neural Recording 1,2 2 2 2 2 2 1 2 C. Moore-Kochlacs , J. Scholvin , J. Kinney , J. Bernstein , Y. Yoon , S. Arfin , N. Kopell , and E. Boyden 1 2 Boston University, Boston, MA, Massachusetts Institute of Technology, Cambridge, MA Track: Undergraduate - OP-Sat-3-14 - Room 204B Undergraduate Research II Chairs: William Guilford, Kristine Ropella 3:15PM AAV9-based Gene Delivery for Cardiac Regeneration via Fibroblast Reprogramming 1 1 S. Hansen and B. French 1 University of Virginia, Charlottesville, VA 3:25PM Promoting Elastin Production in Tissue-Engineered Blood Vessels by Inhibiting microRNA-29 in Human Neonatal Dermal Fibroblasts 1 1 1 1 S. Perez , C. Fernandez , W. Reichert , and G. Truskey 1 Duke University, Durham, NC 3:35PM Washing with Human Albumin Improves the Ability of Stored Red Blood Cells to Perfuse an Artificial Microvascular Network 1 1 1 R. Abidi , N. Piety , and S. Shevkoplyas 1 University of Houston, Houston, TX 3:45PM The Effect of Lovastatin Treatment on Activated Endothelial Cell Gene Expression and Monocyte Adhesion 1 2 2 2 K. Henderson , C. Fernandez , W. Reichert , and G. Truskey 1 2 University of Missouri-Columbia, Kansas City, MO, Duke University, Durham, NC 3:55PM New Chameleon NanoCluster Beacons for Emission-Spectrum-Based SNP Detection 1 1 1 1 D. Imphean , R. Batson , J. Obliosca , and H-C. Yeh 1 University of Texas at Austin, Austin, TX BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 33 of 34 4:05PM Single-cell Transfection Within a 3D Tumor Model Using Optoporation 1 2 3 3 1,2 M. Maurer , M. Monaghan , Y. Möller , M. Olayioye , and K. Schenke-Layland 1 2 Eberhard-Karls-University Tübingen, Tübingen, Germany, Fraunhofer Institute for Interfacial Engineering and 3 Biotechnology (IGB), Stuttgart, Germany, University of Stuttgart, Stuttgart, Germany 4:15PM Computational Fluid Dynamic Modeling of 3D Scaffolds in Dynamic Culture 1 1 1 H. Ko , B. Nguyen , and J. Fisher 1 University of Maryland, College Park, College Park, MD 4:25PM Postural Sway as a Correlate of Psychosis Proneness and Social Behavior 1 2 H. Bothwell and D. Evans 1 2 Bucknell University, Lewisburg, PA, Geisinger-Bucknell Autism and Developmental Medicine Institute, Lewisburg, PA 4:35PM An Enzyme-activatable, Receptor-targeted Filamentous Viral Nanoparticle 1 1 1 P. Chariou , K. Lee , and N. Steinmetz 1 Case Western Reserve University, Cleveland, OH BMES 2014 Annual Meeting – Scientific Program – subject to change – as of 9/10/14 | Page 34 of 34
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