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TABLE OF CONTENTS
REAGENTS PROVIDED AND STORAGE REQUIREMENTS
WARNINGS AND PRECAUTIONS
MATERIALS REQUIRED, BUT NOT PROVIDED
PREPARATION OF REAGENTS
INSTRUCTIONS FOR USE
RECOMMENDED SUPPLIES AND EQUIPMENT
REAGENTS PROVIDED AND STORAGE REQUIREMENTS
Genfind DNA Extraction Kit
95-449
Intended Use: Kit for DNA Extraction
Hologic UK Ltd.
Link 10, Napier Way
Crawley, West Sussex
RH10 9RA UK
+44 (0) 1293 522 080
FOR EXPORT ONLY. NOT FOR SALE IN THE UNITED
STATES OF AMERICA OR CANADA
P/N 15-3221, Revision 102
Table 1: Genfind DNA Extraction Kit (
Requirements
95-449) Contents and Storage
Reagent
Label
Abbreviation
Component
Description
Storage
Requirement
Genfind
Proteinase K
PK
Lyophilized Enzyme
(1 mL vials)
Ultrapure
-30° to -15°C
Store Frozen
Genfind
Lysis Buffer
LB
Cell Lysis Solution
0.45 µm filtered
Genfind
Binding Buffer
BB
Magnetic Bead Solution
0.45 µm filtered
WB
DNA Wash Buffer
(Label marked with blue
stripes)
0.45 µm filtered
Genfind
Wash Buffer
15° to 30°C
Store at room
temperature
2° to 8°C
Refrigerate – Do
Not Freeze
15° to 30°C
Store at room
temperature
WARNINGS AND PRECAUTIONS
1.
For in vitro diagnostic use.
2.
Multiple storage conditions exist; see Table 1.
3.
Universal safety precautions should be used when handling any human
tissues or fluids. Specimens should be disposed of according to local
requirements.
4.
Follow good laboratory practices. Wear protective disposable gloves,
laboratory coats, and eye protection when handling specimens and kit
reagents. Wash hands thoroughly after handling specimens and
reagents.
5.
Do not pool reagents from different lots or from different vials/bottles of
the same lot.
6.
7.
8.
9.
Do not use reagents after their expiration date.
Prior to use, the Proteinase K lyophilized enzyme should be dissolved in
nuclease-free water. A volume of 1 mL of water should be added to
each vial as needed. When resuspended with water, the 1 mL vial of
Proteinase K should be divided into aliquots and again frozen at -30° to
-15°C in a non-frost-free freezer. Thaw only as much Proteinase K as
needed for each extraction. Repeated freezing and thawing of the
enzyme can cause a loss of function.
If a white precipitate has formed in the Wash Buffer, prior to use, gently
shake or stir at room temperature until the solids dissolve. Do not heat
to recombine.
Product components (product residuals, packaging) can be considered
as laboratory waste. Dispose of unused reagents and waste in
accordance with applicable federal, state, and local regulations.




Equipment



MATERIALS REQUIRED, BUT NOT PROVIDED
Table 2: Materials required, but not provided. See Table 5 for a list of
recommended supplies and equipment.
96-well Plate Method
Tube Method
 Pipette tips, filter barrier
 96-well plates
 Pipette tips, filter barrier
 Foil Plate Sealers
Consumable
 Nuclease-free
®
 ABgene 96-well 2.2 mL
Supplies
disposable tubes and
plates
screw caps
 Nuclease-free disposable
tubes and screw caps
Reagents
 2M Tris, pH 7.5
 Nuclease-free water
 70% Ethanol (Molecular
Biology grade)
 Conversion Solution


96-well Plate Method
Pipettes
Vortex
Plate Centrifuge and rotors
SPRI® Plate 96R Super
Magnet Plate
Thermomixer R (Eppendorf)
MTP Block (Eppendorf) and
96 well adapter plate
Digital Dry Block Heater 120
(VWR)
Modular Heating Block for
Titer Plates (VWR)
®
Cervista MTA System for
automation users
Tube Method




Pipettes
Vortex
TubeCentrifuge
SPRI® Stand Magnetic 6
Tube
 Thermomixer R
(Eppendorf)
 MTP Block (Eppendorf)
and 2.0 mL tube adapter
plate
PREPARATION OF REAGENTS
Equilibrate all reagents to room temperature prior to use.
1. Prepare a 10mM Tris solution from a 2M, pH 7.5 Tris stock solution. For
processing a 96-well plate of samples, a recommended preparation is
shown in Table 3.
Table 3: Preparation of 10 mM Tris,.
 2M Tris, pH 7.5
 Nuclease-free water
 70% Ethanol (Molecular
Biology grade)
Component
Volume
2M Tris, pH 7.5
100 µL
Nuclease-free Water
19.9 mL
Total Solution Volume
20 mL
2. Combine the Lysis Buffer and Proteinase K (96 µg/µL) in an
appropriate-sized conical tube according to Table 4. Mix by pipetting up
and down.
2
Table 4: Preparation of Lysis Buffer.
Volume/
Sample
Number
of Samples (x)
Lysis Buffer
400 µL
x
(400 µL)(x)(1.2)
Proteinase K
9 µL
x
(9 µL)(x)(1.2)
409 µL
x
(409 µL)(x)(1.2)
Component
LB/PK solution
4.
5.
Total Volume
6.
7.
®
INSTRUCTIONS FOR USE FOR CERVISTA MTA SYSTEM
Refer to the Cervista® MTA Operator’s Manual (P/N MAN-02378-002) for the
instructions for use for the Cervista® MTA System.
NOTE: PRIOR TO USE OF THE CERVISTA® MTA SYSTEM FOR GENFIND®
TM
DNA EXTRACTION OF THE SUREPATH LIQUID CYTOLOGY SAMPLE
THE SAMPLE MUST BE TREATED ACCORDING TO THE SAMPLE
CONVERSION PROCEDURE.
NOTE: IF DESIRED, PRESERVCYT® LIQUID CYTOLOGY SAMPLES MAY
BE CO-PROCESSED WITH THE GENFIND DNA EXTRACTION PROCESS
IN ANY EMPTY WELLS OF THE 2.2 ML PLATE CONTAINING THE
CONVERTED SUREPATHTM SAMPLES AND WATER.
INSTRUCTIONS FOR USE FOR MANUAL PROCEDURE
Genfind® DNA Extraction Procedure
Sample Conversion Procedure
SurePath
TM
®
TM
Liquid
PreservCyt Liquid Cytology Samples and converted SurePath
Cytology Samples – 96-well Plate Method
1. Mix the cervical specimen well by vortexing or shaking vigorously. Transfer
2.0 mL of each specimen to a well of a 96-well 2.2 mL plate.
2. Centrifuge the 96 well 2.2 mL plate at approximately 1100 RCF for 10-15
minutes.
®
3. Place the 2.2 mL plate on the SPRI Plate 96R Super Magnet Plate.
Remove the supernatant using a multi-channel pipette or a 96-well
aspirator and pump (pressure of aspirator should be approximately 100 mm
Hg vac). Remove approximately 1.9 mL of the supernatant leaving 50-100
µL of residual volume. Take care to only remove supernatant and not
cellular material. NOTE: IF USING AN ASPIRATOR RINSE WITH FRESH
DISTILLED WATER FOLLOWING STEPS 3, 8, 11, 12, and 14.
4. Add 400 µL of the Lysis Buffer/proteinase K mixture to each well containing
sample of the 96-well plate. NOTE: USE NEW TIPS FOR EACH SAMPLE
WELL IN ALL LIQUID TRANSFER STEPS.
Liquid Cytology Samples – 96-well Plate Method
NOTE: THE SUREPATHTM LIQUID CYTOLOGY SAMPLE USED IN THIS
METHOD IS THE RESIDUAL ENRICHED PELLET CERVICAL SAMPLE
PROCESSED ACCORDING TO THE PREPSTAIN™ SLIDE PROCESSOR
OPERATOR’S MANUAL – PREPSTAIN™ PROCESS PROCEDURE.
1.
2.
3.
Add 0.2 mL Conversion Solution to each sample.
Incubate the plate on a Digital Dry Block Heater set to 115°C (+/- 2°C) for
60 minutes.
Upon incubation completion, remove plate from the heat block.
Transfer the entire contents of each converted sample to a well of a second
2.2 mL plate containing 1.59mL of water. NOTE: USE NEW TIPS FOR
EACH SAMPLE LIQUID TRANSFER.
For the Manual 96-well plate method, continue to step 2 of the section
“PreservCyt® Liquid Cytology Samples and converted SurePathTM
Liquid Cytology Samples – 96-well Plate Method”.
®
For the MTA System, refer to the Cervista MTA Operator’s Manual
(Part Number MAN-02378-002) for the instructions for use for the
Cervista® MTA System.
Mix the residual enriched pellet cervical sample well by vortexing or
shaking vigorously. Transfer 1.0 mL of each sample to a well of a 96-well
2.2 mL plate.
Centrifuge the 96 well 2.2mL plate at approximately 1100 RCF for 10
minutes.
®
Place the 2.2 mL plate on the SPRI Plate 96R Super Magnet Plate.
Remove the supernatant using a multi-channel pipette or a 96-well
aspirator and pump (pressure of aspirator should be approximately 100 mm
Hg vac). Remove the supernatant leaving 50-100 µL of residual volume.
Take care to only remove supernatant and not cellular material. NOTE: IF
USING AN ASPIRATOR, RINSE THE ASPIRATOR WITH FRESH
DISTILLED WATER FOLLOWING THIS STEP.
5.
3
Incubate the plate on a thermomixer for 15 minutes at 37C +/-2C and
1000 rpm. NOTE: AFTER THIS STEP, TURN THE THERMOMIXER
THERMOSTAT OFF. THE THERMOMIXER THERMOSTAT SHOULD
REMAIN OFF FOR ALL SUBSEQUENT STEPS.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
IMPORTANT: Mix the Binding Buffer thoroughly by inverting the bottle
many times, making sure the beads are fully resuspended. After mixing,
add 200 µL to each well containing sample of the 96-well plate.
Place the plate on a thermomixer and mix at 1000 rpm for 2-3 minutes.
Place the SPRI® Plate 96R Super Magnet Plate on the spacer and place
the 2.2mL plate on the magnet for 4-6 minutes or until beads form a distinct
ring and solution is clear. Aspirate the entire supernatant taking care not to
disturb the beads. NOTE: USE OF A SPACER IS NECESSARY FOR ALL
SUBSEQUENT ASPIRATION STEPS IF USING THE 96 WELL
ASPIRATOR AND PUMP.
Remove the plate from the magnet and spacer and add 400 µL of Wash
Buffer to the plate wells containing beads.
Place the plate on a thermomixer and mix at 1000 rpm for 4-6 minutes.
Place the SPRI® Plate 96R Super Magnet Plate on the spacer and place
the 2.2mL plate on the magnet for 4-6 minutes or until beads form a distinct
ring and solution is clear. Aspirate entire supernatant taking care to not
disturb the beads. NOTE: The plate should remain on the magnet and
spacer during steps 12-14.
Add 400 µL of 70% ethanol to the wells containing beads and incubate for
30-60 seconds. The beads should form a distinct ring. Aspirate entire
supernatant.
Repeat the 70% ethanol wash by adding 400 µL 70% of ethanol to the
wells containing beads and incubate for 30-60 seconds. The beads should
form a distinct ring. Aspirate entire supernatant.
Allow the beads to air dry for 3-4 minutes. NOTE: IT IS IMPORTANT TO
REMOVE ALL RESIDUAL ETHANOL BEFORE PROCEEDING TO THE
NEXT STEP.
Remove the plate from the magnet and add 120 µL of 10mM Tris to each
well containing beads.
Place the plate on a thermomixer and alternate mixing at:
i. 1000 rpm for 2-3 minutes
ii. Let stand for 2-3 minutes.
iii. 1000 rpm for 2-3 minutes.
Place the plate on a magnet for 10 minutes or until beads form a distinct
ring and solution is clear.
While the plate is still on the magnet, transfer 110 µL of the DNA solution to
a clean 96-well PCR plate using a multi-channel pipette.
If the beads are present visually in the DNA solution, place the 96-well PCR
plate on the magnet and allow any particles to settle. While the plate is still
on a magnet, transfer 100 µL of DNA to a clean 96-well PCR plate. Seal the
plate with a foil plate sealer.
20. DNA can be stored at 4–8C for up to four weeks. For storage longer than
four weeks, store the sample DNA in a –20 or –80C non-frost-free
freezer.
®
PreservCyt Liquid Cytology Samples – Tube Method
NOTE: THE TUBE METHOD HAS NOT BEEN VALIDATED FOR USE WITH
TM
THE SUREPATH LIQUID CYTOLOGY SAMPLE.
1. Mix the cervical specimen well by vortexing or shaking vigorously. Transfer
2.0 mL of each specimen into a labeled 2.0 mL screw-cap tube and cap the
tube.
2. Centrifuge at approximately 1100 RCF for 10-15 minutes.
3. Remove the supernatant using a pipette. Remove approximately 1.9mL of
the supernatant leaving 50-100 µL of residual volume. Take care to only
remove supernatant and not cellular material.
4. Add 400 µL of the Lysis Buffer/proteinase K mixture to each tube. NOTE:
USE NEW TIPS FOR EACH SAMPLE IN ALL LIQUID TRANSFER STEPS.
5. Incubate the tubes in a thermomixer for 15 minutes at 37°C +/-2°C and
1000 rpm. NOTE: AFTER THIS STEP, TURN THE THERMOMIXER
THERMOSTAT OFF. THE THERMOMIXER THERMOSTAT SHOULD
REMAIN OFF FOR ALL SUBSEQUENT STEPS.
6. IMPORTANT: Mix the Binding Buffer thoroughly by inverting the bottle
many times, making sure the beads are fully resuspended. After mixing,
add 200 µL to each tube.
7. Place the tubes in the thermomixer and mix at 1000 rpm for 2-3 minutes.
8. Place sample tubes on the magnet for 4-6 minutes and wait for solution to
clear. While the tubes are still on the magnet, remove supernatant with a
pipette.
9. Remove the tubes from the magnet and add 400 µL of Wash Buffer to each
tube.
10. Place the tubes in the thermomixer and mix at 1000 rpm for 4-6 minutes.
11. Place sample tubes on the magnet for 4-6 minutes and wait for solution to
clear. While the tubes are still on the magnet, remove supernatant with a
pipette.
12. Add 400 µL of 70% ethanol to each sample, place the tubes in the
thermomixer and mix at 1000 rpm for 1 minute.
13. Place the sample tubes on the magnet for 4-6 minutes and wait for the
solution to clear. While the tubes are still on the magnet, remove
4
14.
15.
16.
17.
18.
19.
20.
21.
22.
supernatant with a pipette. Note: Tubes should remain on the magnet
during steps 14 and 15.
Repeat the 70% ethanol wash by adding 400 µL of 70% ethanol to the
samples and let stand for 30-60 seconds. Do not resuspend the beads.
Remove supernatant with a pipette.
Repeat the 70% ethanol wash again by adding 400 µL of 70% ethanol to
the samples and let stand for 30-60 seconds. Do not resuspend the beads.
Remove supernatant with a pipette.
Place the tubes in the thermomixer and mix at 1000 rpm for 3-4 minutes to
dry the beads. NOTE: IT IS IMPORTANT TO REMOVE ALL RESIDUAL
ETHANOL BEFORE PROCEEDING TO THE NEXT STEP.
Remove the tubes from the magnet and add 120 µL of 10mM Tris to each
sample.
Place the tubes in the thermomixer and alternate mixing at:
i. 1000 rpm for 2-3 minutes
ii. Let stand for 2-3 minutes.
iii. 1000 rpm for 2-3 minutes.
Place the tubes on the magnet for 10 minutes or wait for solution to clear.
While the tubes are still on the magnet, transfer 110 µL of the DNA solution
to a clean tube.
If beads are present visually in the DNA solution, place the sample back on
the magnet. While the sample is still on the magnet, transfer 100 µL of DNA
to a clean tube. Cap the tube.
DNA can be stored at 4–8°C for up to four weeks. For storage longer than
four weeks, store the sample DNA in a –20° or –80°C non-frost-free
freezer.
Microplate Exchangeable Thermoblock (Eppendorf/Fisher
Scientific): 05-400-35
Microplate Exchangeable Thermoblock, 2.0mL Tubes
(Eppendorf/Fisher Scientific): 05-400-204
Thermomixer® w/ MTP Adapter (Eppendorf/Fisher
Scientific):05-400-205
Vacuum pump (Gast/Fisher Scientific): 01-092-29
Vacuum pump (Gast/Fisher Scientific): 01-092-26
Centrifuge, Benchtop (Thermo/Fisher Scientific): 75412452
Centrifuge, Benchtop (Thermo/Fisher Scientific): 75004240
Benchtop Centrifuge w/30 tube rotor (Eppendorf/Fisher
Scientific): 022620509
Benchtop Centrifuge w/30 tube rotor (Eppendorf/Fisher
Scientific): 022620525
VWR Digital Dry Block Heater 120 (12621-088)
VWR Modular Heating Block for Titer Plates (13259-295)
Cervista® MTA System for automation users
Conversion Solution – (for use with SurePathTM Liquid
Cytology cervical samples)
2.2mL deep well plates (Abgene/Fisher Scientific): BC-3082
Aspirator and spacer (includes tubes, stoppers and
connectors)
SPRI® Plate 96R Super Magnet (Beckman Coulter /Fisher
Scientific): NC9596962
SPRI® Magnetic 6 Tube Stand (Beckman Coulter /Fisher
Scientific): 001139
16-1001
12-240 (115V)
12-241 (115V)
12-262 (230V)
LEQ-00002
(120V)
LEQ-00004
(230V)
NA
NA
16-005
NA
Contact Information:
Manufacturer:
Hologic, Inc.
502 S. Rosa Road
Madison, WI, 53719 USA
Phone: 608.273.8933
Website: www.hologic.com
Technical Support:
TABLE 5: RECOMMENDED SUPPLIES AND EQUIPMENT
Supplies and Equipment
12-239
Hologic
Part Number
PRD-01406
Access routes for Technical Support outside of the US will
be advised by your local representative.
Distributors:
Contact Hologic, Inc. for a list of worldwide suppliers and
distributors.
Phone: 608.273.8933
Website: www.Hologic.com
PRD-01457
LBS-00006
12-234
12-238
16-1000
5
remainder of the Warranty Period or ninety (90) days from Delivery, whichever
is longer. Consumable Supplies are warranted to conform to published
specifications for a period ending on the expiration date shown on their
respective packages. Services are warranted to be supplied in a workman-like
manner. Hologic does not warrant that use of Products will be uninterrupted or
error-free, or that Products will operate with non-Hologic authorized third-party
products. HOLOGIC'S ENTIRE WARRANTY RESPONSIBILITY IS
EXPRESSLY LIMITED TO REPAIR OR REPLACEMENT (AT HOLOGIC'S
OPTION AND IN THE FORM ORIGINALLY SHIPPED) OF PRODUCT OR
CORRECTION OF SERVICE SUBJECT TO ANY CLAIM, OR, AT HOLOGIC'S
ELECTION, REPAYMENT OF, OR CREDITING CUSTOMER WITH, AN
AMOUNT EQUAL TO THE HOLOGIC PRICE, FEE OR CHARGE
THEREFORE. THE FOREGOING WARRANTIES ARE IN LIEU OF AND
EXCLUDE ALL OTHER WARRANTIES NOT EXPRESSLY SET FORTH
HEREIN, WHETHER EXPRESS OR IMPLIED BY OPERATION OF LAW OR
OTHERWISE, INCLUDING BUT NOT LIMITED TO ANY IMPLIED
WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR
PURPOSE. SUCH LIMITED WARRANTY IS GIVEN SOLELY TO THE
ORIGINAL CUSTOMER AND IS NOT GIVEN TO, NOR MAY IT BE RELIED
UPON BY, ANY THIRD PARTY INCLUDING, WITHOUT LIMITATION,
CUSTOMERS OF CUSTOMER.
THIS WARRANTY IS VOID UPON
TRANSFER OF PRODUCT BY CUSTOMER TO ANY ENTITY WHO HAS
LESS THAN FIFTY (50) PERCENT OWNERSHIP IN THE PRODUCT. SOME
STATES DO NOT ALLOW THE EXCLUSION OF IMPLIED WARRANTIES SO
THE ABOVE EXCLUSIONS MAY NOT APPLY TO YOU. YOU MAY ALSO
HAVE OTHER RIGHTS, WHICH VARY, FROM STATE TO STATE. These
warranties do not apply to any item that is: (a) repaired, moved or altered other
than by Hologic authorized service personnel; (b) subjected to physical
(including thermal or electrical) abuse, stress, or misuse; (c) stored, maintained
or operated in any manner inconsistent with applicable Hologic specifications
or instructions; or (d) designated as supplied subject to a non-Hologic warranty
or on a pre-release or "as-is" basis.
Authorized Representative for the European Community:
Hologic UK Ltd.
Link 10, Napier Way
Crawley, West Sussex
RH10 9RA UK
+44 (0) 1293 522 080
NOTICE TO RECIPIENT ABOUT LIMITED LICENSE
The Genfind DNA Extraction Kit is manufactured for Hologic, Inc. by
Beckman Coulter. The receipt of this product from Hologic or its authorized
distributor includes a limited, non-exclusive, non-transferable license under
patent rights held by Beckman Coulter. Acquisition of this product constitutes
acceptance by the recipient of this limited license. Recipients unwilling to
accept the limited license must return the product for a full refund. Such
license is solely for the purposes of using this product to isolate genomic
material. The foregoing license does not include a license to use the product
for new product research or development, product manufacture, any reverseengineering purposes, improvement to this product technology or any other
commercial purpose. The purchaser of this product is not authorized to
transfer this product to any third party for any purpose without the express
written consent of Hologic. Except as expressly provided in this paragraph, no
other license is granted expressly, impliedly, or by estoppel. For information
concerning the availability of additional licenses to practice the patented
methodologies, contact:
Legal Department, Hologic, Inc., 502 South Rosa Rd., Madison, WI, 53719,
(608) 273-8933.
The Genfind DNA Extraction Kit utilizes SPRI paramagnetic bead
technology and additional components, covered under U.S. Patent Nos.
5,705,628; 5,898,071; 6,534,262 and any corresponding international
equivalents.
WARRANTY CLAIMS AND REMEDIES. In the event of any warranty claim,
Hologic will replace with new or repaired items any Equipment part,
component, or consumable supply that is in breach of warranty, and will use
reasonable efforts to promptly fix or provide a workaround for any Software
defect or bug which prevents operation in substantial conformity with functional
specifications. Alternatively, Hologic may elect to repay or credit to Customer
an amount equal to the purchase price of the defective Equipment, component,
Software, consumable supply, or Service. Items replaced shall become
Hologic property. All claims shall be initiated by contacting Hologic within the
applicable warranty period and thirty (30) days after discovery of the breach or
non-conformity. Hologic must be given reasonable access and an opportunity
to inspect all associated materials. If Hologic and Customer are unable to
LIMITED PRODUCT WARRANTY
WARRANTIES. Equipment, Supplies, and Software are warranted to the
original Customer to perform substantially in accordance with published
Product Specifications for one (1) year starting from the date of Installation (if
applicable) or from the date of Delivery, whichever occurs first. After-sale
options and accessories are warranted for six (6) months, and x-ray tubes are
warranted on a straight-line prorated basis as stated in the applicable Product
Specification (“Warranty Period"). Replacement parts are warranted for the
6
settle any claim and Customer has not notified Hologic within one (1) year after
the claim arises, Customer shall be barred from instituting any legal action
thereafter. These remedies shall comprise Hologic's entire liability and
Customer's exclusive remedy for breach of warranty and are in lieu of any
other remedies at law or equity.
LIMIT OF LIABILITY. HOLOGIC SHALL NOT BE LIABLE FOR ANY
SPECIAL, INCIDENTAL, PUNITIVE, EXEMPLARY OR CONSEQUENTIAL
LOSSES, DAMAGES, OR EXPENSES (INCLUDING BUT NOT LIMITED TO
LOSS OF PROFITS, DATA, OR USE), DIRECTLY OR INDIRECTLY ARISING
FROM THE SALE, HANDLING, SERVICE OR USE OF PRODUCT
ORDERED OR FURNISHED, OR FROM ANY CAUSE RELATING THERETO
UNLESS EXPRESSLY AGREED TO BY THE PARTIES IN WRITING.
EXCEPT FOR PERSONAL INJURY OR DEATH TO THE EXTENT
RESULTING FROM HOLOGIC’S NEGLIGENT OR INTENTIONALLY
WRONGFUL ACTS OR OMISSIONS, IN NO EVENT SHALL HOLOGIC BE
LIABLE UNDER ANY LEGAL THEORY OR FOR ANY CAUSE
WHATSOEVER, WHETHER BASED UPON WARRANTY, CONTRACT,
TORT, NEGLIGENCE, OR OTHER THEORY, EVEN IF ADVISED OF THE
POSSIBILITY THEREOF, FOR ANY AMOUNT IN EXCESS OF THE PRICE,
FEE OR CHARGE THEREFORE RECEIVED BY HOLOGIC.
PreservCyt® is a registered trademark of Hologic, Inc. SPRI and Genfind are
registered trademarks of Beckman Coulter. All other trademarks/registered
trademarks referenced within this product insert, are the property of each of
their respective companies.
©2011 Hologic, Inc.
P/N 15-3221, Revision 102
7