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CURRICULUM VITAE/December, 2013
NAME
KNIP, Jan Mikael
DATE AND PLACE OF BIRTH
September 28, 1950, Kvevlax, Finland
CITIZENSHIP
Finland
CURRENT RESIDENCE
Helsinki
EDUCATION AND TRAINING
M.D., University of Oulu, Oulu, Finland
M.Sc.D. (Ph.D.), University of Oulu, Oulu, Finland
Title of doctoral dissertation: Endocrine pancreatic function and its regulation in infants and children in normal and pathological conditions
Speciality in Pediatrics, National Board of Health, Helsinki, Finland
Subspeciality in Pediatric Endocrinology, National Board of Health,
Helsinki, Finland
Special competence in diabetology, Finnish Medical Association
Docent in Pediatrics, University of Oulu
LINGUISTIC SKILLS
Mother tongue
Other languages:
CURRENT POSITIONS
Professor of Pediatrics, Children’s Hospital, University of Helsinki
Chief Physician, Children’s Hospital, Helsinki University Central
Hospital
Project Director, Department of Pediatrics, Tampere University Hospital
October 10, 1976
May 24, 1983
September 30, 1985
November 20, 1989
May 15, 1995
April 1, 1989
Swedish
Finnish (excellent)
English (excellent)
August 1, 2000August 1, 2000June 1, 2001-
ESSENTIAL PREVIOUS PROFESSIONAL AND RESEARCH EXPERIENCE
Research Associate, Medical Research Council, Academy of Finland,
1979-83
total 52 months
House Officer, Department of Pediatrics, Oulu University Hospital,
1983-86
total 36months
Postdoctoral Research Fellow, Division of Endocrinology, Research
1986-87
Institute of the Hospital for Sick Children, Toronto, Ontario, Canada,
total 16 months
Lecturer in Pediatrics, University of Oulu, total 22 months
1988
Secretary General/Scientist, Nordic Council for Arctic Medical Research, 1990-95
total 60 months
Senior Scientist’s Career Grant, Medical Research Council, Academy of
1995-96
Finland, total 12 months
Acting Professor of Pediatrics, Medical School, University of Tampere,
1996-97
total 12 months
Senior Scientist, Medical Research Council, Academy of Finland;
1997-98
total 12 months
Professor of Pediatrics, Medical School, University of Tampere,
1998-2000
total 24 months
Chair, Children’s Hospital, University of Helsinki, total 19 months
2001-2011
total 91 months
Senior Scientist, Medical Research Council, Academy of Finland;
2002- 2003
total 12 months
Dean, National Graduate School of Clinical Investigation, total 61 months 2003-2008
MAJOR RESEARCH FUNDING OVER THE LAST 5 YEARS
Medical Research Council, Academy of Finland
- Nutritional prevention of childhood type 1 diabetes, € 93,750
- Multidisciplinary approach for the control of gene-environment interactions causing allergy epidemic, € 140,510
2008-2009
2009-2012
1
- Nutritional prevention of childhood type 1 diabetes, € 400,000
- Center of Excellence (CoE) for Molecular Systems Immunology
and Physiology, € 360,000/year
Tampere University Hospital
- Prediction and prevention of type 1 diabetes, approximately €
60,000/year
Helsinki University Central Hospital
- Pathogenesis of type 1 diabetes: From genetic susceptibility to clinical
disease and its prevention, € 60,000/year
-Pathogenesis of type 1 diabetes: From genetic susceptibility to clinical
disease and its prevention, € 60,000/year
- Pathogenesis of type 1 diabetes: From genetic susceptibility to clinical
disease and its prevention, € 38,300/year
Novo Nordisk Foundation
- Molecular pathogenesis of type 1 diabetes: From genetic susceptibility
to clinical disease, € 30,000-40,000/year
Juvenile Diabetes Research Foundation (JDRF)
- Characterization of beta-cell autoimmunity in preclinical type
1 diabetes, USD 165,000/year
- Validation of a metabolic signature protecting against type 1 diabetes,
USD 110,000
Sigrid Juselius Foundation
- Characterization of beta-cell autoimmunity in preclinical type
1 diabetes, € 80,000/year
National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK)
- Early dietary intervention and later signs of beta-cell autoimmunity:
Potential mechanisms, USD 1,851,860
National Institute of Child Health and Human Development (NICHD)
- Trial to reduce IDDM in the genetically at risk (TRIGR), USD
2,200,000/year
EU, 7th Framework
- Pathogenesis of type 1 diabetes: Testing the hygiene hypothesis
(DIABIMMUNE), € 5,999,901
- Persistent virus infection as a cause of pathogenic inflammation in type 1
diabetes (PEVNET), € 362,400
MERITS IN TEACHING AND PEDAGOGICAL COMPETENCE
- Responsible for the undergraduate course in pediatrics, University of
Helsinki
- Responsible for the specialist training in pediatrics, University of
- Helsinki
- Dean, National Graduate School of Clinical Investigation, total 61 months
- Responsible for the undergraduate course in pediatrics, University of
Tampere
- Responsible for the specialist training in pediatrics, University of
- Tampere
- Pedagogic course in problem-based learning, University of Tampere
Doctoral dissertations
Supervisor for completed doctoral dissertations
- Jukka Karjalainen, University of Oulu (together with Hans K. Åkerblom)
- Päivi Tapanainen, University of Oulu
- Outi Nuutinen, Universities of Kuopio and Oulu (together with
Matti Uusitupa)
- Kimmo Talvensaari, University of Oulu (together with Marjatta Lanning)
- Paula Vähäsalo, University of Oulu
- Riitta Veijola, University of Oulu (together with Jorma Ilonen)
- Tuija Löppönen, University of Oulu
- Johanna Rättyä, University of Oulu (together with Jouko Isojärvi)
- Jorma Komulainen, University of Kuopio (together with Hans K.
Åkerblom)
- Emad Sabbah, University of Oulu
- Petri Kulmala, University of Oulu
2010-2013
2012-2017
20082008-2009
2010-2012
2013-2015
2008-2011
2006-2009
2013-2014
2008-2014
2012-2015
2008-2016
2008-2014
2011-2015
20102008-2010
2003-2008
1998-2000
2008-2010
1998-2000
1996
1989
1989
1992
1995
1996
1996
1997
2000
2000
2000
2000
2
- Kaisa Savola, University of Oulu
- Anu-Maaria Hämäläinen, University of Oulu
- Teija Kimpimäki, University of Tampere
- Päivi Riihimaa, University of Oulu (together with Päivi Tapanainen)
- Anna Toivonen, University of Tampere
- Sanna Hoppu, University of Tampere
- Matti Ronkainen, University of Oulu
- Virpi Pylvänen, University of Oulu (together with Jouko Isojärvi)
- Samy Mrena, University of Helsinki
- Marika Kukko, University of Tampere (together with Päivi Keskinen)
- Liisa Uusitalo, University of Tampere (together with Suvi Virtanen)
- Anita Kondrashova, University of Tampere (together with Heikki Hyöty)
- Heli Siljander, University of Helsinki
- Janne Nieminen, University of Helsinki (together with Outi Vaarala)
Supervisor for doctoral dissertations under preparation
- Susanna Aspholm, University of Helsinki
- Anne Hekkala, University of Oulu (together with Riitta Veijola)
- Eeva Jason, University of Tampere
- Anna Parkkola, University of Helsinki
- Petra Pöllänen, University of Helsinki
- Kirsi Salonen, University of Helsinki
RESEARCH AWARDS AND HONORS
Scholarship from the Medical Research Council of Canada
Dissertation Award, Alma and K.A. Snellman Foundation, Oulu, Finland
Knud Lundbaek Award, Scandinavian Society for the Study of Diabetes
Maud Kuistila Award for Scientific Achievement
The Medica Award for high quality and clinically important research
within the field of pediatric internal medicine, Finska Läkaresällskapet
Novo Nordisk Lecture, Scandinavian Society for the Study of Diabetes
Research Award, European Society for Paediatric Endocrinology (ESPE)
The Johnny Ludvigsson Award, the Swedish Child Diabetes Foundation
Honorary Doctor, Medical Faculty, University of Tartu
OTHER ACADEMIC AND PROFESSIONAL ACTIVITIES
Pre-examiner of doctoral dissertations
- Anna-Maija Haavisto, University of Turku
- Raija Anttila, University of Helsinki
- Samu Sarna, University of Helsinki
- Elina Hermanson, University of Helsnki
- Kaisa Karjalainen, University of Oulu
- Taina Härkönen, University of Helsinki
- Eeva Löflund, University of Oulu
- Sini Laakso, University of Helsinkik
Opponent for doctoral dissertations
- Ritva Sorri, University of Helsinki
- Outi Mäkitie, University of Helsinki
- Ekaterine Bakhtadze, Lund University, Sweden
- Marit Bjørnvold, University of Oslo, Norway
- Ilse Vermeulen, Free University Brussels, Belgium
Reviewer of docent application
- Leo Dunkel, University of Helsinki
- Annelie Carlsson, Lund University, Sweden
Reviewer of guest professor application
- Stefano Cianfarani, Karolinska Institute
Activities in scientific societies
Scandinavian Society for the Study of Diabetes (SSSD)
- Member of the Board, President (1995)
European Association for the Study of Diabetes (EASD)
- Council Member
International Society for Pediatric and Adolescent Diabetes (ISPAD)
- Member, Advisory Council
Immunology Diabetes Society (IDS)
2000
2001
2002
2003
2005
2005
2005
2005
2005
2005
2009
2009
2010
2013
1986-87
1987
1999
2004
2006
2006
2006
2010
2012
1996
1996
1997
1998
2000
2002
2007
2012
1989
1992
2009
2009
2012
1990
2009
2012
19791990-97
19892000-2003
19901999-2002
19963
- Treasurer
Finnish Diabetes Research Society
- Member of the Board
Finnish Society of Sciences and Letters, member
Other scientific activities
European Nicotinamide Diabetes Intervention Trial (ENDIT)
- Deputy Coordinator
Medical Advisory Board, Finnish Diabetes Association
- Member
- Vice-Chairman
- Chairman
Scientific Committee, European Society for the Study of Diabetes
- 31st Annual Meeting, Stockholm
- 32nd Annual Meeting, Vienna
- 42nd Annual Meeting, Copenhagen
Scientific Program Committee, 16th International Diabetes Federation
Congress, Helsinki, Finland, July 20-25, 1997
- Vice-Chairman
Biomed 2 - Scientific evaluator
JDRF Medical Science Review Committee
- Member
Research Council, University of Helsinki
- Member
Research Council, Faculty of Medicine, University of Helsinki
- Member
Diabetes Prediction and Prevention Study (DIPP)
- Principal Investigator (PI), one of three PIs
Trial to Reduce IDDM in the Genetically at Risk (TRIGR)
- Deputy PI
- PI
Finnish Pediatric Diabetes Register and Biobank
- PI
The Environmental Determinants of Diabetes in the Young (TEDDY)
- Local PI
Research Council for Health, Academy of Finland
- Member
- Vice Chair
DIAMAP – Road Map for Diabetes Research in Europe, Focused
Sub-Group on Genetics and Epidemiology
- Member
DIABIMMUNE Collaborative Project
- PI
Data Safety Monitoring Board (DSMB), European and North
American Trials with the diabetes vaccine Diamyd®
- Member
Finnish Centre of Excellence in in Molecular Systems Immunology and
Physiology Research
- Deputy Director
Novo Nordisk Foundation
- Member of Nordisk forskningskomite
Diabetes and Obesity Research Program, Medical Faculty, University of
Helsinki
- Director
Editorial Board membership
Arctic Medical Research, Managing Editor
International Growth Monitor, Review Editor
European Journal of Endocrinology, Editor
Journal of Clinical Endocrinology and Metabolism, Editorial Board
Member
Pediatric Diabetes, Editorial Board Member
Lancet Diabetes & Endocrinology, Editorial Board Member
2001-2005
19901990-95
19991992-2003
1992-2003
19901993-94
1994-97
1995
1996
2006
1993-97
1995
2005-2008
2004-2006
2004-2006
19942001-2008
2008200220042007-2009
2010-2012
2008-2010
2008-2013
20082012201220131990-95
1990-2005
2000-2008
2005-2008
200120134
Referee for scientific journals
Acta Paediatrica, Autoimmunity, British Medical Journal, Clinical Endocrinology, Diabetes, Diabetes
Care, Diabetes/Metabolism Research and Reviews, Diabetic Medicine, Diabetologia, European Journal of
Clinical Investigation, European Journal of Clinical Nutrition, European Journal of Endocrinology, European Journal of Pediatrics, FASEB Journal, Human Immunology, Journal of the American Medical Association (JAMA), Journal of Clinical Endocrinology and Metabolism, Journal of Clinical Investigation,
Journal of Pediatrics, Lancet, Nature Reviews Endocrinology, Pediatric Diabetes, Pediatric Research, Pediatrics, PLoS One, Trends in Molecular Medicine
SCIENTIFIC AND SOCIAL IMPACT OF RESEARCH
Publications
490 original papers, 34 manuscripts, 72 reviews and editorials, 71 other publications, and 509 abstracts
(please see separate list)
H-index: 63
Citations: 14,734
Patents or patent applications
Hyöty M, Knip M. Prevention of type 1 diabetes and other non-polio enterovirus diseases. European patent
1187631 706.9 – 2402
Viskari H, Knip M, Seiskari T, Hyöty H, Kummola L, Kondrashova A. Prevention of allergic sensitization.
PCT WO2008/092996
Hyöty H, Knip M, Laitinen O, Tolonen O, Pulkki M, Oikarinen S, Honkanen H-R, Lecouturier V, Almond
J. Enterovirus vaccines for preventing or treating type 1 diabetes (I). European patent application
10305714.7
Hyöty H, Knip M, Laitinen O, Tolonen O, Pulkki M, Oikarinen S, Honkanen H-R, Lecouturier V, Almond
J. Diagnostic assay for type 1 diabetes. PCT application PCT/EP2011/061001
Spin-off company
Vactech Ltd, aims at developing picornavirus vaccines, an antidiabetogenic enterovirus vaccine,in particular
- Board member
2008POSITIONS OF TRUST IN SOCIETY AND OTHER SOCIAL MERITS
- Vasa nation, Inspector
2006- The Association of Friends of the University Children's Hospitals,
2010board member
- UNICEF Finland, board member
2011-
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