1. No category

Clinical
Research Experts
in the Hospital District of South West Finland and the
University of Turku
This catalogue is a collection of clinical research experts in the Hospital District of South
West Finland and the University of Turku. It has been compiled in collaboration with Turku
Science Park Ltd, to complement the material on the know-how of BioTurku®
(http://www.turkusciencepark.com/default.asp?viewID=395).
The catalogue lists the primary research interests, experience, qualifications and contact
information of clinicians and scientists from a variety of therapy areas. This catalogue is
aimed to attract the interest of the pharmaceutical industry and other medical and
biotechnological companies, who have a need for a clinical research expert. We also hope it
will be helpful to various research institutes and other scientists interested in research
collaboration.
If you are a clinical researcher at the hospital district or University of Turku and wish to enter
your details in this catalogue, please contact Turku Clinical Research Centre at
turkucrc(at)tyks.fi.
Tässä luettelossa esitellään Varsinais-Suomen sairaanhoitopiirin ja Turun yliopiston kliinisen
tutkimuksen asiantuntijoita. Sen koonti on tehty yhteistyössä Turku Science Park Oy:n kanssa
täydentämään BioTurun® osaamisesta kertovaa materiaalia,
(http://www.turkusciencepark.com/default.asp?viewID=267).
Asiantuntijaluetteloon on koottu kliinikoiden ja tutkijoiden yhteystiedot sekä tietoja heidän
pätevyydestään, ensisijaisista tutkimuskohteistaan ja -kokemuksestaan. Luettelo on
suunnattu lääketeollisuudessa työskenteleville sekä niille lääketieteen ja bioteknologian
yrityksille, joilla on tarve kliinisen tutkimuksen asiantuntijalle. Toivomme sen olevan
hyödyksi myös muille tutkimusorganisaatioille sekä toisille tutkijoille, jotka ovat
kiinnostuneet tutkimusyhteistyöstä.
Jos olet kliininen tutkija sairaanhoitopiirissä tai Turun yliopistossa ja haluat saada tietosi
tähän luetteloon, ota yhteyttä Turun kliiniseen tutkimuskeskukseen, turkucrc(at)tyks.fi.
Contact details
Vesa Aaltonen
MD, PhD
Department of Ophthalmology,
Turku University Hospital
Kiinamyllynkatu 4-8, PL 52
FI-20521 Turku
Finland
or
Department of Anatomy,
University of Turku
FI-20014 University of Turku
Finland
e-mail: [email protected]
Curriculum Vitae
Degrees
Current and relevant
previous positions
PhD | 2007 | University of Oulu
MD | 2000 | University of Turku
Specialising Physician | 2008-| Department of Ophthalmology, Turku University Hospital
Clinical lecturer | 2008- | Department of Anatomy, University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research
experience
Oncology: Urinary bladder cancer, Neurofibromatosis Type 1
hypoxia, Neurofibromatosis Type 1
Ophthalmology: Retinal
Other medical research
Principal investigator
0–5 years
Representative publications
Koivunen J, Aaltonen V, Koskela S, Lehenkari P, Laato M, Peltonen J. Protein kinase C alpha/beta inhibitor Go6976 promotes formation of
cell junctions and inhibits invasion of urinary bladder carcinoma cells. Cancer Res. 2004; 64(16):5693-5701.
Koivunen J, Aaltonen V, Peltonen J. Protein kinase C (PKC) family in cancer progression. Cancer Lett. 2006; 235(1):1-10.
Aaltonen V, Koivunen J, Laato M, Peltonen J. PKC inhibitor Go6976 induces mitosis and enhances doxorubicin-paclitaxel cytotoxicity in
urinary bladder carcinoma cells. Cancer Lett. 2007; 253(1):97-107.
Aaltonen V, Peltonen J. PKCalpha/beta I inhibitor Go6976 induces dephosphorylation of constitutively hyperphosphorylated Rb and G1
arrest in T24 cells. Anticancer Res. 2010; 30(10):3995-3999.
Aaltonen V, Boström PJ, Söderström KO, Hirvonen O, Tuukkanen J, Nurmi M, Laato M, Peltonen J. Urinary bladder transitional cell
carcinogenesis is associated with down-regulation of NF1 tumor suppressor gene in vivo and in vitro. Am J Pathol. 1999; 154(3):755-765.
Updated Nov-12
Contact details
Sleep Research Unit,
Department of Physiology,
Turku University
Lemminkäisenkatu 2
FI-20520 Turku
Finland
Ulla Anttalainen
MD, PhD
e-mail: [email protected]
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Pulmonology and Allergology | 2002 | University of Turku
PhD | 2008 | University of Turku
MD | 1994 | University of Turku
Medical Specialist | 2002- | Dept of Pulmonary Diseases, Turku University Hospital
Researcher | 1998- | Dept of Physiology, Turku University
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research
experience
GCP training
Pulmonary Diseases: Allergology, Asthma, Sleep Disorders
Clinical trials on medicinal products
Sub-investigator
Over 15 years
GCP-training organised by a previous sponsor
and GSCS
Clinical Investigator's Training / TurkuCRC
Representative publications
Anttalainen U, Saaresranta T, Aittokallio J, Kalleinen N, Vahlberg T, Virtanen I, Polo O. Impact on Menopause on the Manifestation and
Severity of Sleep-disordered Breathing. Acta Obstet et Gynec Scand. 2006; 85:1381-1388.
Anttalainen U, Saaresranta T, Kalleinen N, et al. CPAP Adherence and Partial Upper Airway Obstruction during Sleep. Sleep and
Breathing. 2007; 11:171-177.
Anttalainen U, Saaresranta T, Kalleinen N et al. Gender Differences in Age and BMI Distributions in Partial Upper Airway Obstruction
during Sleep. Respir Physiol Neurobiol. 2007; 15:219-26.
Anttalainen U, Polo O, Vahlberg T, Saaresranta T. Reimbursed drugs in patients with sleep-disordered breathing - a static-chargesensitive bed study. Sleep Medicine. 2010; 11:49-55.
Anttalainen U, Polo O, Saaresranta T. Is "mild" sleep-disordered breathing in women really mild? Acta Obstet et Gynec Scand. 2010;
89:606-611.
Updated Nov-12
Contact details
Eeva Ekholm
Department of Obstetrics
and Gynaecology
Turku University Hospital
Kiinamyllynkatu 4-8
FI-20520 Turku
Finland
Docent
e-mail: [email protected]
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Obstetrics and Gynaecology | 1995 | University of Turku
Specialist Degree in Perinatology | 2001 | University of Turku
PhD | 1994 | University of Turku
MD | 1986 | University of Turku
Medical Specialist | 1995- | Turku University Hospital
Adjunct Professor / Docent | 2002- | University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Experience with
vulnerable study subjects
Total clinical research
experience
GCP training
Additional information
Obstetrics and Gynaecology: Perinatology, Ultrasound
Clinical trials on medicinal products
Principal investigator
Clinical trials on medical devices
Sub-investigator
Pregnant women / nursing mothers
Over 15 years
GCP-training organised by a previous sponsor
Pregnancy physiology, maternal-fetal medicine, drug research on contraception and
climacteric symptoms.
Updated Nov-12
Contact details
Reidar Grénman
Dept of Otorhinolaryngology Head and Neck Surgery,
Turku University and
Turku University Hospital
PO Box 52
FI-20521 Turku
Finland
Professor
e-mail: [email protected]
phone: 35823131500
fax: 35823133550
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Oto-rhino-laryngology - Head and Neck Surgery | 1983 | University
of Turku
PhD | 1985 | University of Turku
MD | 1977 | University of Turku
Chief Physician | 2001- | Turku University Hospital
Professor | 2001- | University of Turku
Adjunct Professor / Docent | 1991 | University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research
experience
Resources available for clinical
research
Oncology: Head and Neck Cancers
Other medical research
Principal investigator
Otorhinolaryngology: Oncology, Otology, Surgery
Observational trials
Sub-investigator
Over 25 years
The staff at the department of ORL-HNS consists of 24 physicians and 120 other staff. All
help and assist in clinical research as needed.
Three physicians are employed by the university and have primary responsibility of
conducting research, the other 12 specialist physician do research as time allows.
At any time 4-6 Ph.D theses are ongoing, annually 20-30 articles in international scientific
series are published.
Assisting personnel or laboratory facilities are not available at the ENT department for
basic research. The facilities for clinical research are good and the basic research is done
in collaboration with the respective basic science units at Turku University.
Updated Nov-12
Contact details
Leena Haataja
Professor
Department of Child
Neurology,
Turku University Hospital
PO Box 52
FI-20521 Turku
Finland
e-mail: [email protected]
phone: +358 2 3131464
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Child Neurology | 2002 | University of Turku
PhD | 1996 | University of Turku
MD | 1991 | University of Turku
Chief Physician | 2004- | Department of Child Neurology, Turku University Hospital
Medical Specialist | 2002-2004 | Department of Child Neurology, Turku University Hospital
Researcher | 1988-1993 | Research Assistant of Medical Genetics, University of Turku
Professor | 2010- | Child neurology, Turku University
Adjunct Professor / Docent | 2002-2009 | Child neurology, University of Turku
Clinical Research Fellow | 1996-1998 | Dept. of Paediatrics and Neonatal Medicine,
Hammersmith Hospital, London
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Experience with
vulnerable study subjects
Total clinical research
experience
GCP training
Medical Imaging: Radiology
Obstetrics and Gynaecology: Perinatology
Paediatrics:
Genetics, Infectious Diseases, Neonatology, Neurology Ophthalmology: Visual Disabilities
Other medical research
Principal investigator
Minors
Sub-investigator
Person in charge of research (national trials)
Persons not able to give consent
10–15 years
GCP -training / Pharmaceutical Information Centre
Representative publications
Haataja L, Schleutker J, Laine A-P, et al. The genetic locus for free sialic acid storage disease maps to the long arm of chromosome 6. Am J
Hum Genet. 1994; 54:1042-1049.
Haataja L, Mercuri E, Regev R, et al. Optimality score for the neurologic examination of the infant at 12 and 18 months of age. J Pediatr.
1999; 135:153-161.
Reiman M, Kujari H, Ekholm E, Lapinleimu H, Lehtonen L, Haataja L and the PIPARI Study Group. Interleukin-6 Polymorphism is
Associated with Chorioamnionitis and Neonatal Infections in Preterm Infants. J Pediatr. 2008; 153:19-24.
Maunu J, Lehtonen L, Lapinleimu H, Matomäki J, Munck P, Rikalainen H, Parkkola R, Haataja L. Ventricular dilatation in relation to
outcome at 2 in very preterm infants: a prospective Finnish cohort study. Dev Med Child Neurol. 2011; 53(1):48-54.
Updated Nov-12
Contact details
Jarna Hannukainen
PhD
Turku PET Centre,
University of Turku
Kiinamyllynkaty 4-8
PO Box 52
FI-20521 Turku
Finland
e-mail:
[email protected]
web page:
www.turkupetcentre.fi
phone: +358 2 3131878
Curriculum Vitae
Degrees
Current and relevant previous
positions
PhD | 2006 | University of Turku
MSc | 2002 | University of Jyväskylä
Researcher | 2006 | Turku PET Centre, University of Turku
Coordinator of the Finnish Centre of Excellence in Molecular Imaging in
Cardiovascular and Metabolic Research
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research
experience
Medical Imaging: PET
Exercise Physiology
Other medical research
Sub-investigator
Person in charge of research (national trials)
5–10 years
Representative publications
Hannukainen JC, Borra R, Lindeborg K, Kallio H, Kiss J, Lepomäki V, Kalliokoski KK, Kujala UM, Kaprio J, Heinonen OJ, Komu M, Parkkola R,
Ahotupa M, Lehtimäki T, Huupponen R, Nuutila P. Liver and pancreatic fat content and metabolism in healthy monozygotic twins
discordant for physical activity. Journal of Hepatology, 2011; 54(3):545-552.
Hannukainen JC, Kalliokoski KK, Borra R, Viljanen A, Janatuinen, Kujala UM, Kaprio J, Heinonen OJ, Viljanen T, Haaparanta M, Iozzo P,
Parkkola R, Nuutila P. Higher free fatty acid uptake in visceral than in abdominal subcutaneous fat tissue in men. Obesity. 2010;
18(2):261-265.
Hannukainen JC, Nuutila P, Ronald B, Kaprio J, Kujala UM, Janatuinen T, Heinonen OJ, Kapanen J, Viljanen T, Haaparanta M, Rönnemaa T,
Parkkola R, Knuuti J, Kalliokoski KK. Increased physical activity decreases hepatic free fatty acid uptake: a study in human monozygotic
twins. J Physiol. 2007; 578:347-358.
Hirvonen J, Virtanen KA, Nummenmaa L, Hannukainen JC, Honka M-J, Bucci M, Nesterov SV, Parkkola R, Rinne J, Iozzo P, Nuutila P.
Effects of Insulin on Brain Glucose Metabolism in Impaired Glucose Tolerance. Diabetes, 2011; 60(2):443-447.
Hannukainen J.C., Nuutila P., Kaprio J., Heinonen O.J., Kujala U.M., Janatuinen T., Rönnemaa T., Kapanen J., Haaparanta-Solin M., Viljanen
T., Knuuti J., Kalliokoski K.K. Relationship between local perfusion and FFA uptake in human skeletal muscle – no effect of increased
physical activity and aerobic fitness. J Appl Physiol. 2006; 101(5):1303-1311.
Updated Nov-12
Contact details
Niina Hieta
Dept of Dermatology and
Venereology
Turku University Hospital,
Hämeentie 11
FI-20520 Turku
Finland
MD, PhD
e-mail: [email protected]
phone: +358 2 3132616
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Dermatology and Allergology| 2008 | University of Turku
PhD | 2001 | University of Turku
MD | 1996 | University of Turku
Medical Specialist | 2008- | Turku University Hospital
Specialising Physician | 2002-2008 | Turku University Hospital
Clinical teacher | 2007- | University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research
experience
Dermatology: Allergology, Dermatology
Other medical research
Sub-investigator
0–5 years
Representative publications
Hieta N, Hasan T, Mäkinen-Kiljunen S, Lammintausta K. Makea lupiini - uusi ruoka-allergeeni. Aikakauskirja Duodecim. 2010; 126:13931399.
Hieta N, Hasan T, Mäkinen-Kiljunen S, Lammintausta K. Lupin allergy and lupin sensitization among patients with suspected food allergy.
Ann Allergy Asthma Immunol. 2009; 103:233-237.
Hieta N, Impola U, Lopez-Otin C, Saarialho-Kere U, Kähäri VM. Matrix metalloproteinase-19 expression in dermal wounds and by
fibroblasts in culture. J Invest Dermatol. 2003; 121:997-1004.
Impola U, Toriseva M, Suomela S, Jeskanen L, Hieta N, Jahkola T, Grenman R, Kähäri VM, Saarialho-Kere U. Matrix metalloproteinase-19
is expressed by proliferating epithelium but disappears with neoplastic dedifferentiation. Int J Cancer. 2003; 103:709-716.
Reunanen N, Li SP, Ahonen M, Foschi M, Han J, Kähäri VM. Activation of p38 alpha MAPK enhances collagenase-1 (matrix
metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization. J Biol Chem. 2002; 277:32360-32368.
Updated Nov-12
Contact details
Riikka Huovinen
Department of Oncology and
Radiotherapy,
Turku University Hospital
PO Box 52
FI-20521 Turku
Finland
MD, PhD, Docent
e-mail: [email protected]
phone: +358 2 3130000
mobile: +358 40 5761959
fax: +358 2 3132809
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Oncology | 1992 | University of Turku
PhD | 1995 | University of Turku
MD | 1984 | University of Turku
Medical Specialist | 1995- | Dept. of Oncology and Radiotherapy, Turku University Hospital
Adjunct Professor / Docent | 2006 | University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research
experience
GCP training
Resources available for
clinical research
Oncology: Breast Cancer
Clinical trials on medicinal products
Other medical research
Observational trials
Principal investigator Sub-investigator Person in charge of research (national trials)
Person in charge of research (international trials)
Over 15 years
GCP web based test / Pharmaceutical Information Centre
Resources in the Department of Oncology and Radiotherapy, Turku University Central
Hospital: 4 study nurses, hospital laboratory and radiological and isotope imaging
Representative publications
Penttinen HM, Saarto T, Kellokumpu-Lehtinen P, Blomqvist C, Huovinen R, Kautiainen H, Järvenpää S, Nikander R, Idman I, Luoto R,
Sievänen H, Utriainen M, Vehmanen L, Jääskeläinen AS, Elme A, Ruohola J, Luoma M, Hakamies-Blomqvist L. Quality of life and physical
performance and activity of breast cancer patients after adjuvant treatments. Psychooncology. 2011; 20:1211-20
Joensuu H, Kellokumpu-Lehtinen PL, Huovinen R, Jukkola-Vuorinen A, Tanner M, Asola R, Kokko R, Ahlgren J, Auvinen P, Hemminki A,
Paija O, Helle L, Nuortio L, Villman K, Nilsson G, Lahtela SL, Lehtiö K, Pajunen M, Poikonen P, Nyandoto P, Kataja V, Bono P, Leinonen M,
Lindman H; FinXX Study Investigators. Adjuvant capecitabine in combination with docetaxel and cyclophosphamide plus epirubicin for
breast cancer: an open-label, randomised controlled trial. Lancet Oncol. 2009; 10:1145-1151.
Jalava P, Kuopio T, Huovinen R, Laine J, Collan Y. Immunohistochemical staining of estrogen and progesterone receptors: aspects for
evaluating positivity and defining the cutpoints. Anticancer Res. 2005; 25(3c):2535-2542.
Saarinen NM, Huovinen R, Wärri A, Mäkelä SI, Valentín-Blasini L, Sjöholm R, Ammälä J, Lehtilä R, Eckerman C, Collan YU, Santti RS.
Enterolactone inhibits the growth of 7,12-dimethylbenz(a)anthracene-induced mammary carcinomas in the rat.Mol Cancer Ther. 2002;
1(10):869-876.
Saarinen NM, Huovinen R, Wärri A, Mäkelä SI, Valentín-Blasini L, Needham L, Eckerman C, Collan YU, Santti R. Uptake and metabolism of
hydroxymatairesinol in relation to its anticarcinogenicity in DMBA-induced rat mammary carcinoma model. Nutr Cancer. 2001; 41(12):82-90.
Updated Nov-12
Contact details
Tuija S. Ikonen
MD, PhD, Docent
Department of Surgery,
Turku University Hospital
Kiinamyllynkatu 4-8
FI-20521 TURKU
Finland
e-mail: [email protected]
phone: +358 40 5442331
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Surgery | 1991 | University of Helsinki
Specialist Degree in Cardiothoracic and Vascular Surgery | 1994 | University of Helsinki
PhD | 1997 | University of Helsinki
MD | 1883 | University of Helsinki
Chief Specialist | 2003 | Turku University Hospital
Adjunct Professor / Docent | 2000| University of Helsinki
SMO | 2007 | THL, National Institute of Health and Welfare
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical
trials
Total clinical research
experience
Additional information
Medical Imaging: Radiology
Transplantation
Surgery: Cardiothoracic Surgery, Vascular Surgery,
Clinical trials on medicinal products
Other medical research
Sub-investigator
Observational trials
Person in charge of research (national trials)
10–15 years
Vascular surgery, patient safety, mainly observational and registry-based studies,
experimental surgery.
Representative publications
Ikonen TS, Sund R, Venermo M, Winell K. Fewer major amputations among individuals with diabetes in Finland in 1997–2007 - A
population-based study. Diabetes Care. 2010; 33:2598-2603.
Implementation of WHO Surgical Checklist in four Finnish Hospitals: improved activity and changes in attitudes. Submitted.
Söderström M, Vikatmaa P, Lepäntalo M, Aho PS, Kolho E, Ikonen T. The consequences of an outbreak of multidrug-resistant
Pseudomonas aeruginosa among patients treated for critical leg ischemia. J Vasc Surg. 2009; 50:806-812.
Vikatmaa P, Lajunen T, Ikonen TS, Pussinen PJ, Lepäntalo M, Leinonen M, Saikku P. Chlamydial lipopolysaccharide (cLPS) is present at
atherosclerotic and aneurysmal arterial wall - cLPS levels depend on disease manifestation. Cardiovascular Pathology. 2010; 19:48-54.
Ikonen T, Harjula ALJ, Kivisaari L, Piilonen A, Taskinen E. High-Resolution CT in long-term follow up after Lung Transplantation, Chest.
1997; 111:370-376.
Updated Nov-12
Contact details
Panu Jaakkola
MD, PhD
Turku Centre for Biotechnology,
University of Turku
Biocity, Tykistökatu 6B
FI-20520 Turku
Finland
e-mail: [email protected]
web page: www.btk.fi/research/
research-groups/jaakkola-panuhypoxia-group/
phone: +358 2 3338030
mobile: +358 44 5483806
fax: +358 2 3338000
Curriculum Vitae
Degrees
Current and relevant
previous positions
PhD | 1998 | University of Turku
MD | 1992 | University of Turku
Specialising Physician | 2006- | Department of Oncology and Radiotherapy, Turku University
Hospital
Researcher | 2001- | Turku Centre for Biotechnology, University of Turku
Clinical research
Therapeutic areas
Oncology: Breast cancer, Prostate cancer, Head and Neck cancers, Colorectal cancer
Previous clinical trials
Other medical research
Total clinical research
experience
5–10 years
Resources available for
clinical research
Additional information
Full resources of Centre for Biotechnology for basic and imaging research.
Translational research between basic life sciences (cell and molecular cancer research) and
clinical cancer research.
Representative publications
Heikkinen P, Nummela M, Kähäri VM, Jaakkola PM. Hypoxia converts Smad7 from tumor suppressor into tumor promoter. Cancer Res.
2010; 70(14):5984-5993.
Rantanen K, Pursiheimo J, Högel H, Himanen V, Metzen E, Jaakkola PM. Prolyl hydroxylase PHD3 activates oxygen-dependent protein
aggregation. Mol Biol Cell. 2008; 19(5):2231-2240.
Jokilehto T, Rantanen K, Luukkaa M, Heikkinen P, Grenman R, Minn H, Kronqvist P, Jaakkola PM. Overexpression and nuclear
translocation of HIF prolyl hydroxylase PHD2 in HNSCC associates with tumor aggressiveness. Clin Cancer Res. 2006; 12(4):1080-1087.
Epstein ACR, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, et al. C. elegans EGL-9 and mammalian homologues define a
family of dioxygenases that regulate HIF through prolyl hydroxylation. Cell. 2001; 107: 43-54.
Jaakkola P, Mole DR, Tian Y-M, Wilson MI, Gielbert J, Gaskell SJ, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation
complex by O2-regulated prolyl hydroxylation. Science. 2001; 292: 468-472.
Updated Nov-12
Contact details
Sirkku Jyrkkiö
MD, PhD, Docent
Department of Oncology and
Radiotherapy,
Turku University Hospital
PO Box 52
FI-20521 Turku
Finland
e-mail: [email protected]
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Oncology | 1998| University of Turku
PhD | 1992| University of Turku
MD | 1987 | University of Turku
Chief Specialist | 2006-| Dept of Oncology and Radiotherapy, Turku University Hospital
Adjunct Professor / Docent | 2000- | University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research
experience
GCP training
Oncology: Lymphoma
Clinical trials on medicinal products
Person in charge of research (international trials)
10–15 years
GCP web based test / Pharmaceutical Information Centre
Updated Nov-12
Satu K. Jääskeläinen
Professor, MD, PhD
Contact details
Department of Clinical
Neurophysiology, Public
Utility TYKS-SAPA, PO Box 52,
20521 Turku
e-mail:
[email protected]
web page:
www.tbmc.fi/en/satu-kjaeaeskelaeinen
phone: +35823131939, fax:
+35823133922
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Clinical Neurophysiology | 1993 | University of Turku
PhD | 1995 | University of Turku
MD | 1985 | University of Turku
Chief Physician | 2009 - | Department of Clinical Neurophysiology, Public Utility
Associate Chief Physician | 2006 -2007 | Dept. of Clinical Neurophysiology, TUH
Chief Specialist | 2007 - 2008 | Dept. of Clinical Neurophysiology, TUH
Medical Specialist | 1993 - 2006 | Dept. of Clinical Neurophysiology, TUH
Professor | 2009 - | Dept. of Clinical Neurophysiology, University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Experience with vulnerable
study subjects
Total clinical research
experience
Resources available for
clinical research
Additional information
Anaesthesiology and Intensive Care: Anaesthesiology, Intensive Care, Pain Relief, Depth of
Anaestesia Monitoring
Medical Imaging: PET
Neurology: Brain Injuries, Epilepsy,
Neurocritical Care, Neuropathic Pain, Peripheral Neuropathy, Neuromuscular Disorders
Oral diseases: Oral and Maxillofacial Surgery, Facial Pain Orthopaedics and Traumatology:
Nerve Trauma and Repair,
Surgery: Neurosurgery, Intraoperative Neurophysiologic
Monitoring, Neuromodulation Clinical Neurophysiology, Neuromodulation (rTMS)
Clinical trials on medicinal products and medical devices
Principal investigator
Sub-investigator
Other medical research
Person in charge of research (national trials
Minors
Over 15 years
Dept of clinical neurophysiology (equipment, staff) according to contract details
Prevention, diagnosis, risk factors and incidence of peripheral neuropathy and pain; diagnostic
value of psychophysical and neurophysiological methods, techniques for intraoperative and depth
of anaesthesia monitoring; pathophysiology of orofacial pain, genetics and neurotransmitter system
imaging (PET); neuromodulation with repetitive transcranial magnetic stimulation
Representative publications
Jääskeläinen SK. Pathophysiology of primary burning mouth syndrome. Clin Neurophysiol. 2012; 123:71-77 (invited review).
Hagelberg N, Forssell H, Rinne JO, Scheinin H, Taiminen T, Aalto S, Luutonen S, Någren K, Jääskeläinen S. Striatal dopamine D1 and D2
receptors in burning mouth syndrome. Pain. 2003; 101:149-154.
Jääskeläinen SK, et al. Sevoflurane is epileptogenic in healthy subjects at surgical levels of anesthesia. Neurology. 2003; 61:1073-1078.
Jääskeläinen SK, Rinne JO, et al. Role of the dopaminergic system in chronic pain -- a fluorodopa-PET study. Pain. 2001; 90:257-260.
Jääskeläinen SK, Teerijoki-Oksa T, Forssell K, Vähätalo K, Peltola JK, Forssell H. Intraoperative monitoring of the inferior alveolar nerve
during mandibular sagittal-split osteotomy. Muscle Nerve. 2000; 23:368-375.
Updated Nov-12
Contact details
Valtteri Kaasinen
Docent
Department of Neurology,
University of Turku
POB 52
FIN-20521 Turku
Finland
e-mail:
[email protected]
phone: +358 2 3131720
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Neurology | 2008 | University of Turku
PhD | 2000 | University of Turku
MD | 1996 | University of Turku
Medical Specialist | 2008- | Turku University Hospital
Adjunct Professor / Docent | 2005 | Experimental Neurology, University of Turku
Postdoctoral Research Fellow | 2003-2004 | Department of Neurology, Groningen
University Hospital, The Netherlands
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research
experience
GCP training
Medical Imaging: Nuclear Medicine, PET
Movement Disorders
Clinical trials on medicinal products
Principal investigator
Neurology: Neurodegenerative Diseases,
Other medical research
Observational trials
Sub-investigator
Over 15 years
GCP-training organised by a previous sponsor
Resources available for clinical
research
The technical and other supporting staff of Turku PET Centre is well experienced to
perform PET studies with various 15O, 11C and 18F labelled tracers.
Additional information
Experience in designing and conducting clinical brain neurotransmission research trials.
Primary methods: brain PET and MRI (voxel-based morphometry and diffusion tensor
imaging)
Representative publications
Kaasinen V, Nurmi E, Bergman J, Eskola O, Solin O, Sonninen P, Rinne JO. Personality traits and brain dopaminergic function in early
Parkinson’s disease. Proc Natl Acad Sci USA. 2001; 98:13272-13277.
Kaasinen V, Nurmi E, Brück A, Eskola O, Bergman J, Solin O, Rinne JO. Increased frontal [18F]flurodopa uptake in early Parkinson’s
disease: sex differences in the prefrontal cortex. Brain. 2001; 124:1125-1130.
Haltia LT, Viljanen A, Parkkola R, Kemppainen N, Rinne JO, Nuutila P, Kaasinen V. Brain white matter expansion in human obesity and the
recovering effect of dieting. J Clin Endocrinol Metab. 2007; 92:3278-3284.
Haltia LT, Rinne JO, Merisaari H, Maguire RP, Savontaus E, Helin S, Någren K, Kaasinen V. Effects of intravenous glucose on dopaminergic
function in the human brain in vivo. Synapse. 2007; 61:748-756.
Kaasinen V, Aalto S, Någren K, Rinne JO. Expectation of caffeine induces dopaminergic responses in humans. Eur J Neurosci 2004;
19:2352-2356.
Updated Nov-12
H arry
Contact details
Kari Kalliokoski
Turku PET Centre,
University of Turku
c/o TYKS
Kiinamyllynkatu 4-8
FI-20520 Turku
Finland
PhD, adjunct professor
e-mail: [email protected]
web page: http://www.exercise.fi
phone: +358 2 3132782
mobile: +358 40 5145437
fax: +358 2 2318191
Curriculum Vitae
Degrees
Current and
relevant previous
positions
PhD | 2001 | University of Turku
MSc (exercise physiology) | 1998 | University of Jyväskylä
Researcher | 1998- | Turku PET Centre, University of Turku
Adjunct Professor / Docent | 2004- | Dept of Physiology, University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical
trials
Total clinical research
experience
Resources available
for clinical research
Internal Medicine: Cardiology, Endocrinology
Physiology
Clinical trials on medicinal products
Sub-investigator
Medical Imaging: Radiology, PET
Exercise
Other medical research
Project manager
10–15 years
Turku PET Centre resources available.
Representative publications
Hannukainen JC, Kalliokoski KK, Borra R, Viljanen A, Janatuinen T, Kujala UM, Kaprio J, Heinonen OJ, Viljanen T, Haaparanta M, Iozzo P,
Parkkola R, Nuutila P. Higher free fatty acid uptake in visceral than in abdominal subcutaneous fat tissue in men. Obesity, 18:261-265,
2010.
Heinonen I, Nesterov SV, Liukko K, Kemppainen J, Någren K, Luotolahti M, Virsu P, Oikonen V, Nuutila P, Kujala UM, Kainulainen H,
Boushel R, Knuuti J, Kalliokoski KK. Myocardial blood flow and adenosine A2A receptor density in endurance athletes and untrained men.
Journal of Physiology (London), 586:5193-5202, 2008.
Knuuti J, Kalliokoski R, Janatuinen T, Hannukainen J, Kalliokoski KK, Koskenvuo J, Lundt S. Effect of estradiol-drospirenone hormone
treatment on myocardial perfusion reserve in postmenopausal women with angina pectoris. American Journal of Cardiology, 99:16481652,2007.
Kalliokoski RJ, Kantola I, Kalliokoski KK, Engblom E, Sundell J, Hannukainen JC, Janatuinen T, Raitakari OT, Knuuti J, Penttinen M, Viikari J,
Nuutila P. The effect of 12-month enzyme replacement therapy on myocardial perfusion in patients with Fabry disease. Journal of
Inherited Metabolic Disease 29:112-118, 2006.
Stolen KQ, Kemppainen J, Ukkonen H, Kalliokoski KK, Luotolahti M, Lehikoinen P, Hämäläinen H, Salo T, Airaksinen KEJ, Nuutila P, Knuuti
J. Exercise training improves biventricular oxidative metabolism and left ventricular efficiency in patients with dilated cardiomyopathy.
Journal of the American College of Cardiology, 41:460-467, 2003.
Updated Nov-12
Contact details
Department of Internal
Medicine,
Turku University Hospital
Kiinamyllynkatu 4-8
FI-20520 Turku
Finland
Ilkka Kantola
Docent
e-mail: [email protected]
phone: +358 2 3130130
mobile: +358 40 0628858
fax: +358 2 3132030
Curriculum Vitae
Degrees
Current and relevant previous
positions
Specialist Degree in Internal Medicine | 1984 | University of Turku
Specialist Degree in Hypertension | 2001 | European Society of Hypertension
PhD | 1988 | University of Turku
MD | 1978 | University of Turku
Specialist administrative medicine | 2005 | University of Turku
Chief Specialist | 2005- | Department of Internal Medicine, Turku University Hospital
Adjunct Professor / Docent | 1997 | University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research experience
GCP training
Resources available for clinical
research
Additional information
Clinical Pharmacology Internal Medicine: Cardiology, Endocrinology, Hypertension,
Hyperlipidemia, Obesity, Sleep Apnea, Diabetes Mellitus Fabry Disease
Clinical trials on medicinal products
medical research Observational trials
Principal investigator
trials)
Sub-investigator
Clinical trials on medical devices
Other
Person in charge of research (national
Over 15 years
GCP -training and test / Pharmaceutical Information Centre
Pharmaceutical Information Centre
GCP web based test /
Two study nurses, two rooms with equipment.
Participated in about 50 trials concerning hypertension, hyperlipidemia, diabetes,
obesity, Fabry disease.
Representative publications
Varis J, Kantola I. The choice of home blood pressure result reporting method is essential: Results mailed to physicians did not improve
hypertension control compared with ordinary office-based blood pressure treatment. Blood Press. 2010; 19:319-324.
Korhonen P, Aarnio P, Vesalainen R, Saaresranta T, Kautiainen H, Järvenpää S, Kantola I. Hypertensive women with the metabolic
syndrome are at risk of renal insufficiency more than men in general population. J Hum Hypertens. 2009; 23:97-104.
Niiranen TJ, Jula AM, Kantola IM, Reunanen A. Prevalence and determinants of isolated clinic hypertension in the Finnish population: the
Finn-HOME study. J Hypertens. 2006; 24:463-470.
Ahola TL, Jula AM, Kantola IM, Mäki J, Klaukka T, Reunanen A. Positive change in the utilization of antihypertensive and lipid-lowering
drugs among adult diabetics in Finland. Results from large national database between 2000 and 2006. J Hypertens. 2009; 27:2283-2293.
Mehta A, Beck M, Eyskens F, Feliciani C, Kantola I, Ramaswami U, Rolfs A, Rivera A, Waldek S, Germain DP. Fabry disease: a review of
current management strategies. QJM. 2010; 103:641-659.
Updated Nov-12
Contact details
Max Karukivi
MD, PhD
Unit of Adolescent
Psychiatry, Satakunta
Hospital District
Antinkatu 15 A
FI-28100 Pori
Finland
e-mail: [email protected]
phone: +358 2 6274760
fax: +358 2 6274785
Curriculum Vitae
Degrees
Current and relevant previous
positions
PhD | 2011 | University of Turku
MD | 2007 | University of Turku
Specialising Physician | 2008- | Unit of Adolescent Psychiatry, Satakunta Hospital
District
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Experience with vulnerable
study subjects
Total clinical research
experience
GCP training
Psychiatry: Adolescents
Clinical trials on medicinal products
Other medical research
Observational trials
Sub-investigator
Minors
0–5 years
GCP-training organised by a previous sponsor
Representative publications
Karukivi M, Hautala L, Kaleva O, Haapasalo-Pesu KM, Liuksila PR, Joukamaa M, Saarijärvi S. Alexithymia is associated with anxiety among
adolescents. J Affect Disord. 2010; 125:383 387.
Karukivi M, Hautala L, Korpelainen J, Haapasalo-Pesu KM, Liuksila PR, Joukamaa M, Saarijärvi S. Alexithymia and eating disorder
symptoms in adolescents. Eat Disord. 2010; 18:226 238.
Karukivi M, Joukamaa M, Hautala L, Kaleva O, Haapasalo-Pesu KM, Liuksila PR, Saarijärvi S. Does perceived social support and parental
attitude relate to alexithymia? A study in Finnish late adolescents. Psychiatry Res. 2011; 187(1-2):254-29-60.
Karukivi M, Hautala L, Haapasalo-Pesu K-M, Liuksila P-R, Joukamaa M, Saarijärvi S. Nuorten aleksitymia on yhtä yleistä kuin aikuisten.
Suomen Lääkärilehti. 2009; 64:915- 920.
Hautala L, Junnila J, Alin J, Grönroos M, Maunula A-M, Karukivi M, Liuksila P-R, Räihä H, Välimäki M, Saarijärvi S. Uncovering hidden
eating disorders using the SCOFF questionnaire: cross sectional survey of adolescents and comparison with nurse assessments. Int J Nurs
Studies. 2009; 46:1439 1447.
Updated Nov-12
Contact details
Saila Pauliina Kauhanen
PhD
Turku PET Centre and
Department of Surgery,
Turku University Hospital
PO Box 52
FI-20521 Turku
Finland
e-mail: [email protected]
web page:
http://www.turkupetcentre.fi
phone: +358 2 3130209
mobile: +358 50 3017010
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Gastroenterological Surgery | 2007 | Turku University Hospital
PhD | 2009 | University of Turku
MD | 2001 | University of Tampere
Medical Specialist | 2007- | Department of surgery, Turku University Hospital
Specialising Physician | 2002-2007 | Satakunta Central Hospital / Turku University Hospital
Researcher | 2006- | Turku PET Centre
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research
experience
Resources available for
clinical research
Additional information
Medical Imaging: PET
Gastroenterology
Oncology: Neuroendocrinological Tumours Surgery:
Other medical research
Principal investigator
Sub-investigator
0–5 years
Resources of PET Centre (physicist, chemist, nurses, laboratory technicians, cameras, etc.)
PET/CT imaging with special reference to gastroenterological surgery and neuroendocrine
tumors.
Representative publications
Kauhanen S, et al. A prospective diagnostic accuracy study of 18F-FDG-PET/CT, MDCT and MR imaging in primary diagnosis and staging of
pancreatic cancer. Ann Surg. 2009; 250:957-963.
Kauhanen S, et al. Fluorine-18-L-dihydroxyphenylalanine (18F-DOPA) positron emission tomography as a tool to localize an insulinoma or
ß-cell hyperplasia in adult patients. J Clin Endocrinol Metab. 2007; 4:1237- 1244.
Kauhanen S, et al. The Clinical Value of 18F-Fluoro-Dihydroxyphenylalanine Positron Emission Tomography in Primary Diagnosis, Staging
and Restaging of Neuroendocrine Tumors. Endocrine-Related Cancer. 2009; 16:255-265.
Komar G*, Kauhanen S*, et al. Decreased Blood Flow with Increased Metabolic Activity: a Novel Sign of Aggressive Tumor
Aggressiveness. Clin Cancer Res. 2009; 15:5511-5517. *equal contribution
Kauhanen S, et al. Premedication with Carbidopa Masks Positive Finding of Insulinoma and Beta Cell Hyperplasia in 18F-dihydroxyphenyl-alanine Positron Emission Tomography. Correspondence. J Clinical Oncology. 2008; 10:5307-5308.
Updated Nov-12
Contact details
Maritta Kilpeläinen
MD, PhD
Dept of Pulmonary Diseases,
Turku University Hospital
Kiinamyllynkatu 4-8
FI-20520 Turku
Finland
e-mail: [email protected]
phone: +358 2 3134739
mobile: +358 40 5052545
fax: +358 2 3133328
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Pulmonary Diseases | 1993 | University of Turku
Specialist Degree in Allergology | 2005 | University of Turku
PhD | 2001 | University of Turku
MD | 1986 | University of Turku
Medical Specialist | 1993- | Department, Turku University Hospital
Senior Lecturer | 1999- | Dept of Pulmonary Diseases and Clin. Allergology
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research
experience
GCP training
Pulmonary Diseases: Allergology, Asthma, COPD
Clinical trials on medicinal products
Sub-investigator
Other medical research
Observational trials
Person in charge of research (national trials)
Over 15 years
GCP-training organised by a previous sponsor
Resources available for
clinical research
Study nurse, facilities available after 3 p.m.
Additional information
Clinical epidemiology
Representative publications
Kilpeläinen M, Terho E, Helenius H, Koskenvuo M. Farm environment in childhood prevents the development of allergies.Clin Exp Allergy
2000;30:201-208.
Kilpeläinen M, Terho E, Helenius H, Koskenvuo M. Home dampness, current allergic diseases and repsirotry infections in young adults.
Allergy 2001; 56:377-384.
Kilpeläinen M, Koskenvuo M, Helenius H, Terho EO. Stressful life event promote the manifestation of asthma and allergic diseases. Clin
Exp Allergy 2002; 31:1-8.
Kilpeläinen M, Terho E, Helenius H, Koskenvuo M. Body mass index and physical activity in relation to asthma and atopic diseases in
young adults. Respir Med 2006; 100:1518–1525.
Laitinen T, Hodgson U, Kupiainen H, Tammilehto L, Haahtela T, Kilpeläinen M, Lindqvist A, Kinnula VL. Real-world clinical data idnetifies
gender related profiles in chronic obstructive pulmonary disease. J of COPD 2009; 6:256-262.
Updated Nov-12
Contact details
Sirkka-Liisa Kivelä
Professor
Department of Family Medicine
University of Turku,
Lemminkäisenkatu 1
FI-20014 University of Turku
Finland
e-mail: [email protected]
web page: http://www.med.utu.fi
/yleislaak/kivela/
phone: +358 40 5039151
mobile: +358 40 5039151
fax: +358 2 3338439
Curriculum Vitae
Degrees
Current and relevant previous
positions
Specialist Degree in Family medicine | 1971 | National Board of Health
Specialist Degree in Geriatrics | 1986 | National Board of Health
PhD | 1983 | University of Tampere
MD | 1971 | University of Oulu
Chief Physician | 2000- | Turku University Hospital
Chief Physician | 1971-1980 | Posio Health Centre
Researcher | 1985-1986 | Academy of Finland
Professor | 2000- | University of Turku
Professor | 1988-2000 | University of Oulu
Senior lecturer | 1980-1988 | University of Tampere
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Clinical Pharmacology General Practice: Epidemiology, Interventions Geriatrics:
Epidemiology, Interventions
Psychiatry: the Aged, Depression
Pulmonary
Diseases: Asthma, COPD Falls in the Aged
Other medical research
Principal investigator
Observational trials
Person in charge of research (national trials)
Experience with vulnerable study
subjects
Persons not able to give consent
Total clinical research experience
Over 15 years
Resources available for clinical
research
Additional information
Two assisting persons
Several studies about depression, falls, use of medications, prevalence; risk factors
and prognosis in old age.
Representative publications
Salonoja M, Salminen M, Aarnio P, Vahlberg T, Kivelä S-L. One-time counselling decreases the use of benzodiazepines and related drugs
among community-dwelling older persons. Age Ageing. 2010; 39(3):313–319.
Nurminen J, Puustinen J, Piirtola M, Vahlberg T, Kivela S-L: Psychotropic drugs and the risk of fractures in old age: a prospective
population-based study. BMC Public Health. 2010; 10:396–405.
Salminen M, Kuoppamäki M, Vahlberg T, Räihä I, Irjala K, Kivelä S-L. The metabolic syndrome defined by modified International Diabetes
Federation criteria and mortality: a 9-year follow-up study among the aged in Finland. Diabetes & Metab. 2010; 36:437–442.
Salminen M, Vahlberg T, Salonoja M, Aarnio P, Kivelä S-L. Effects of a risk-based multifactorial fall prevention program on the incidence
of falls. J Am Ger Soc. 2009; 57:612-619.
Salminen M, Vahlberg T, Sihvonen S, Sjösten N, Piirtola M, Isoaho R, Aarnio P, Kivelä S-L. Effects of risk-based multifactorial fall
prevention on postural balance in the community-dwelling aged: A randomized controlled trial. Arch Gerontol Geriatr. 2009; 48:22-27.
Updated Nov-12
Contact details
Leena Koulu
Department of Dermatology
Turku University Hospital
PO Box 52
FI-20521 Turku
Finland
MD, PhD
e-mail: [email protected]
phone: +358 2 3131624
fax: +358 2 3131610
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Dermatology | 1993 | University of Turku
Specialist Degree in Dermatological Allergy | 1997 | University of Turku
PhD | 1988 | University of Turku
MD | 1980 | University of Turku
Occupational Supervisor | 2007 | University of Turku
Process Consultant | 2007 | University of Turku
Chief Specialist | 2004- | Department of Dermatology, Turku University Hospital
Adjunct Professor / Docent | 2002- | University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Experience with
vulnerable study subjects
Total clinical research
experience
GCP training
Resources available for
clinical research
Dermatology: Allergology, Dermatology, Photodermatology
Clinical trials on medicinal products
Principal investigator
Psychosomatics
Other medical research
Sub-investigator
Pregnant women / nursing mothers
Over 15 years
GCP-training organised by a previous sponsor
Study coordinator (nurse) and accommodation in the department.
Representative publications
Koulu L, Laihia J, Peltoniemi H-H, Jansen CT. UV-induced tolerance to a contact allergen is impaired in polymorphic light eruption. J Invest
Dermatol. 2010; 130(11):2578-2582.
Linnamaa P, Savolainen J, Koulu L et al. Blackcurrant seed oil for prevention of atopic dermatitis in newborns: a randomised, doubleblind, placebo-controlled trial. Clin Exp Allergy. 2010; 40:1247-1255.
Anttinen A, Koulu L et al. Neurological symptoms and natural course of xeroderma pigmentosum. Brain. 2008; 131:1979-1989.
Koulu L. Effect of ultraviolet irradiation and PUVA treatment on human epidermal Langerhans cell membrane markers. Thesis. Turku
1988. ISBN 951-99960-6-0.
Stanley JR, Koulu L, Klaus-Kovtun V, Steinberg MS. A monoclonal antibody to the desmosomal glycoprotein desmoglein I binds the same
polypeptide as human autoantibodies in pemphigus foliaceus. J Immunol. 1986; 136:1227-1230.
Updated Nov-12
Contact details
Jukka Laine
Department of Pathology,
Turku University Hospital
Kiinamyllynkatu 10
PO Box 52
FI-20520 Turku
Finland
Docent
e-mail: [email protected]
phone: +358 40 7313702
mobile: +358 40 7313702
fax: +358 2 3337459
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Pathology | 2001 | University of Turku
Specialist Degree in Paediatric Pathology | 2009 | University of Oulu
PhD | 1999 | University of Turku
MD | 1994 | University of Turku
Medical Specialist | 2001- | Department of Pathology, Turku University Hospital
Specialising Physician | 1995-2000 | University of Turku / Turku University Hospital
Adjunct Professor / Docent | 2002- | University of Turku
Locum Paediatric Pathology | 2006-2007 | Royal Manchester Children's Hospital
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research
experience
Resources available for clinical
research
Additional information
Pathology: Paediatric Pathology, Placenta
Paediatrics: Neonatology
Other medical research
Sub-investigator
5–10 years
Department of Pathology supplies the basic laboratory and equipments, several
collaborators.
The main focus now is to investigate the causes of the death in pre-and neonatal
period.
Representative publications
Eerola LI, Surrel F, Nevalainen TJ, Gelb MH, Lambeau G, Laine VJO. Analysis of expression of secreted phospholipases A2 in mouse tissues
at protein and mRNA levels. BBA Molecular and Cell Biology of Lipids. 2006; 1761:745-756.
Koduri RS, Grönroos JO, Laine VJO, Le Calvez C, Lambeau G, Nevalainen TJ, Gelb MH. Bactericidal properties of human and murine groups
I, II, V, X, and XII secreted phospholipases A2. J Biol Chem. 2002; 277:5849-5857.
Laine VJO, Grass DS, Nevalainen TJ. Resistance of transgenic mice expressing human group II phospholipase A2 to Escherichia coli
infection. Infect Immun. 2000; 68:87-92.
Laine VJO, Grass DS, Nevalainen TJ. Protection by group II phospholipase A2 against Staphylococcus aureus. J Immunol. 1999; 162:74027408.
Laine VJ, Nyman KM, Peuravuori HJ, Henriksen K, Parvinen M, Nevalainen TJ. Lipopolysaccharide induced apoptosis of rat pancreatic
acinar cells. GUT. 1996; 38:747-752.
Updated Nov-12
Contact details
Päivi Lähteenmäki
Docent, MD, PhD
Department of Paediatrics,
Turku University Hospital
PO BOX 52,
FI-20521 Turku
Finland
e-mail:
[email protected]
phone: +358 2 3130670
mobile: +358 40 7695420
fax: +358 2 3132416
Curriculum Vitae
Degrees
Current and relevant previous
positions
Specialist Degree in Paediatrics | 1999 | University of Turku
Specialist Degree in Paediatric Haematology-Oncology | 2002 | University of Turku
Specialist Degree in Hospital Administration | 2005 | University of Turku
PhD | 1999 | University of Turku
MD | 1984 | University of Turku
Chief Specialist | 2008- | Department of Paediatrics, Turku University Hospital
Medical Specialist | 2002-2008 | Department of Paediatrics, Turku University
Hospital
Researcher | 1997- | Turku Graduate School of Clinical Sciences
Adjunct Professor / Docent | 2008 | University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Paediatrics: Endocrinology, Neonatology, Neurology, Oncology
Clinical trials on medicinal products
Minors
Total clinical research experience
10–15 years
Additional information
Observational trials
Principal investigator Person in charge of research (national trials)
charge of research (international trials)
Experience with vulnerable study
subjects
GCP training
Other medical research
Clinical Chemistry
Person in
Pregnant women / nursing mothers
Clinical Investigator's Training / TurkuCRC and GSCS
Late-effects of childhood cancer is the main interest of my research activity
(nationally and internationally)
Representative publications
Harila-Saari A, Lähteenmäki PM, Kyyrönen P, Laning M, Pukkala E, Sankila R. Scholastic achievements of childhood leukemia patients: a
nationwide, register-based study. J Clin Oncol. 2007; 25:3518-3524.
Lähteenmäki PM, Harila-Saari A, Kyyrönen P, Salmi TT, Pukkala E, Sankila R. Scholastic achievements of children with brain tumors – a
nationwide, register-based study. Neurology. 2007; 69:296-305.
Madanat-Harjuoja LM, Malila N, Lähteenmäki P, Boice JD Jr, Gissler M, Dyba T. Preterm delivery among female survivors of childhood,
adolescent and young adulthood cancer. Int J Cancer. 2010; 127:1669-79.
Järvelä LS, Niinikoski H, Lähteenmäki PM, Heinonen OJ, Kapanen J, Arola M, Kemppainen J. Physical activity and fitness in adolescent and
young adult long-term survivors of childhood acute lymphoblastic leukaemia. J Cancer Surviv. 2010; 4:339-45.
Madanat LMS, Malila N, Dyba T, Hakulinen T, Sankila R, Boice JD Jr. Lähteenmäki PM. Probability of parenthood after early onset cancer: a
population-based study. Int J Cancer. 2008; 123(12):2891-2898.
Updated Nov-12
Contact details
Department of Oncology
and Radiotherapy,
Turku University Hospital
PO BOX 51
20521 Turku
Finland
Heikki Minn
MD
e-mail: [email protected]
phone: + 358 2 3130149
mobile: +358 44 5647335
fax: +358 2 3132809
Curriculum Vitae
Degrees
Current and relevant previous
positions
Specialist Degree in Oncology and Radiotherapy | 1991 | University of Turku
PhD | 1990 | University of Turku
MD | 1984 | University of Turku
Chief Physician | 2007- | Oncology and Radiotherapy, Turku University Hospital
Professor | 2007- | PET Centre, University of Turku
Adjunct Professor / Docent | 1995 | Clinical oncology, University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Medical Imaging: PET Oncology: Prostate Cancer, Head and Neck Cancers, Neurooncology, Neuroendocrine Tumours
Clinical trials on medicinal products
Principal investigator
trials)
Experience with vulnerable study
subjects
Minors
Total clinical research experience
Over 15 years
GCP training
Resources available for clinical
research
Additional information
Other medical research
Sub-investigator
Person in charge of research (national
GCP-training organised by a previous sponsor
TurkuCRC and GSCS
Clinical Investigator's Training /
The Clinical Cancer Research Unit has modern, up-to-date equipment including
modern radiotherapy (RT) devices and research facilities and access to two PET/CT
scanners used in RT planning. The unit is involved in several multi-centre phase II–III
trials of novel drugs having specific molecular targets. The staff includes four
research nurses.
PET tracer development (oncology)
Representative publications
Otonkoski T, Näntö-Salonen K, Seppänen M, Veijola R, Huopio H, Hussain K, Tapanainen P, Eskola O, Parkkola R, Ekström K, Guiot Y,
Rahier J, Laakso M, Rintala R, Nuutila P, Minn H. Noninvasive diagnosis of focal hyperinsulinism of infancy with [18F]-DOPA positron
emission tomography. Diabetes. 2006; 55:13-18.
Lehtiö K, Eskola O, Viljanen T, Oikonen V, Grönroos T, Sillanmäki L, Grénman R, Minn H. Imaging perfusion and hypoxia with PET to
predict radiotherapy response in head and neck cancer. Int J Radiat Oncol Biol Phys. 2004; 59:971-982.
Komar G, Seppänen M, Eskola O, Lindholm P, Grönroos TJ, Forsback S, Sipilä H, Evans SM, Solin O, Minn H. [18F]EF5: a new PET tracer for
imaging hypoxia in head and neck cancer. J Nucl Med. 2008; 49:1944-1951.
Komar G, Kauhanen S, Liukko K, Seppänen M, Kajander S, Ovaska J, Nuutila P, Minn H. Decreased blood flow with increased metabolic
activity: a novel sign of pancreatic tumor aggressiveness. Clin Cancer Res. 2009; 15:5511-5517.
Seppälä J, Seppänen M, Lindholm P, Arponen E, Kulmala J, Minn H. Carbon-11 acetate PET/CT based dose escalated IMRT in prostate
cancer. Radiother Oncol. 2009; 93:234-240.
Updated Nov-12
Juha Mäkinen
Contact details:
Dept Obstetrics and
Gynecology
Turku University Hospital
Kiinamyllynkatu 4-8
FI-20520 Turku Finland
Professor
e-mail:
[email protected]
phone: +358 2 3131364
mobile: +358 400 523529
Curriculum Vitae
Degrees
Specialist Degree in Obstetrics and Gynecology | 1984 | University of Turku
PhD | 1988 | University of Turku
MD | 1978 | University of Turku
Subspeciality in Urogynecology | 1986 | University of Turku
Competence in Medical Education | 2011 | Finnish Medical Association
Current and relevant previous
positions
Chief Physician | 2005 - | Dept. Obstetrics and Gynecology , Turku University
Hospital
Professor | 1998 | Dept. Obstetrics and Gynecology, University of Turku
Adjunct Professor / Docent | 1990 - 1998 | Dept. Obstetrics and Gynecology,
University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research experience
Resources available for clinical
research
Obstetrics and Gynecology: Gynecology, Oncology, Urogynecology
Clinical trials on medicinal products
Principal investigator
Other medical research
Observational trials
Sub-investigator
Over 15 years
Research nurse (2008-2011). Four to six collaborative doctors.
Representative publications
Setälä M, Savolainen H, Kössi J, Ranta T, Mäkinen J. Deeply infiltrating disease in surgically treated endometriosis patients. Acta Obstet
Gynecol Scand. 2011 May;90(5):468-72.
Jalava-Broman J, Mäkinen J, Ojanlatva A, Jokinen K, Sillanmäki L, Rautava P. Change in the frequency of HRT use from 2000 to 2005 and
reasons to discontinue: follow-up of a normal cohort in Finland. Acta Obstet Gynecol Scand. 2011 Apr;90(4):351-7.
Ala-Nissilä S, Haarala M, Mäkinen J. Tension-free vaginal tape - a suitable procedure for patients with recurrent stress urinary
incontinence. Acta Obstet Gynecol Scand. 2010;89(2):210-6.
Kumpulainen S, Sankila R, Leminen A et al. The effect of hospital operative volume, residual tumor and first-line chemotherapy on survival
of ovarian cancer - a prospective nation-wide study in Finland. Gynecol Oncol. 2009 Nov;115(2):199-203.
Huhtinen K, Suvitie P, Hiissa J et al. Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts.
Br J Cancer. 2009 Apr 21;100(8):1315-9.
Updated Nov-12
Contact details
Janne Nurminen
MD
Clinical Medicine,
Family Medicine,
University of Turku
FI-20014 University of Turku
Finland
e-mail: [email protected]
Curriculum Vitae
Degrees
Current and relevant
previous positions
MD | 2008 | University of Turku
Specialising Physician | 2010 | Family Medicine, University of Turku
Researcher | 2005| Family Medicine, University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research
experience
General Practice
Geriatrics
Other medical research
Principal investigator
Sub-investigator
0–5 years
Representative publications
Nurminen J, Puustinen J, Piirtola M, Vahlberg T, Kivelä SL. Psychotropic drugs and the risk of fractures in old age: a prospective
population-based study. BMC Public Health. 2010; 10:396.
Nurminen J, Puustinen J, Kukola M, Kivelä SL. The use of chemical restraints for older long-term hospital patients: a case report from
Finland. J Elder Abuse Negl. 2009; 21(2):89–104.
Updated Nov-12
Contact details
Turku PET Centre,
University of Turku /
Hospital District of
Southwest Finland
PO Box 52
20520 Turku
Finland
Pirjo Nuutila
Professor, MD, PhD
e-mail: [email protected]
web page: www.turkupet.fi
fax: +358 2 2319181
Curriculum Vitae
Degrees
Current and relevant previous
positions
Specialist Degree in Internal Medicine| 1992 | University of Turku
Specialist Degree in Clinical Endocrinology | 1996 | University of Helsinki
Specialist Degree in Diabetology | 1996
PhD | 1992 | University of Turku
MD | 1984 | University of Turku
Diploma in Health Administration | 2007 | University of Turku
Professor | 1998- | Metabolic Research, University of Turku
Chief Physician | 2001- | Department of Internal Medicine, Turku University Hospital
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research
experience
GCP training
Resources available for clinical
research
Additional information
Internal Medicine: Endocrinology
Clinical trials on medicinal products
Medical Imaging: PET
Other medical research
Principal investigator Sub-investigator Person in charge of research (national trials)
Person in charge of research (international trials)
Over 20 years
GCP-training organised by a previous sponsor
TurkuCRC and GSCS
Clinical Investigator's Training /
Staff and equipments of Turku PET centre; clinical researchers; research nurse.
Diabetes, metabolic and endocrinological research using molecular imaging (PET, MRI).
Clinical endocrinology.
Representative publications
Nuutila P, Koivisto VA, Knuuti J, Ruotsalainen U, Teräs M, Haaparanta M, et al. Glucose-free fatty acid cycle operates in human heart and
skeletal muscle in vivo. J Clin Invest. 1992; 89:1767-1744.
Otonkoski T, Näntö-Salonen K, Seppänen M, Veijola R, Huopio H, Hussain K, et al. Noninvasive diagnosis of focal hyperinsulinism of
infancy with [18F]-DOPA positron emission tomography. Diabetes. 2006; 55(1):13-18.
Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerbäck S, Nuutila P. Functional
brown adipose tissue in healthy adults. N Engl J Med. 2009; 360(15):1518-1525.
Kauhanen S, Seppänen M, Ovaska J, Minn H, Bergman J, Korsoff P, et al. The clinical value of [18F]fluoro-dihydroxyphenylalanine positron
emission tomography in primary diagnosis, staging, and restaging of neuroendocrine tumors. Endocr Relat Cancer. 2009; 16(1):255-265.
Viljanen APM, Karmi A, Borra R, Pärkkä JP, Lepomäki V, Parkkola R, et al. Effect of caloric restriction on myocardial fatty acid uptake, left
ventricular mass, and cardiac work in obese adults. Am J Cardiol. 2009; 103(12):1721-1726.
Updated Nov-12
Contact details
Klaus Olkkola
Professor, Chairman
Department of Anaesthesiology,
Intensive Care, Emergency Care
and Pain Medicine
University of Turku and
Turku University Hospital
PO Box 52 (Kiinamyllynkatu 4-8)
FI-20521 Turku
Finland
e-mail: [email protected]
phone: +358 2 3131960
mobile: +358 40 7583655
fax: +358 2 3133960
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Anaesthesiology | 1992 | University of Helsinki
Specialist Degree in Clinical Pharmacology | 1992 | University of Helsinki
PhD | 1985 | University of Helsinki
MD | 1983 | University of Helsinki
Chief Physician | 2003- | Department of Anaesthesiology, Intensive Care, Emergency
Care and Pain Medicine, Turku University Hospital
Professor | 2003- | Department of Anaesthesiology, Intensive Care, Emergency Care and
Pain Medicine, University of Turku
Director | 2008- | Institute of Clinical Medicine, University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Experience with vulnerable
study subjects
Total clinical research
experience
Additional information
Anaesthesiology and Intensive Care: Anaesthesiology, Emergency Medicine, Pain Relief
Clinical Pharmacology
Clinical trials on medicinal products
Principal investigator
Other medical research
Sub-investigator
Observational trials
Person in charge of research (national trials)
Minors
Over 15 years
Pharmacokinetics, pharmacodynamics and drug interactions in anaesthesiology, intensive
care, emergency care and pain medicine
Representative publications
Olkkola KT, Backman J, Neuvonen PJ. Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or
itraconazole. Clin Pharmacol Ther. 1994; 55:481-485.
Olkkola KT, Hamunen K, Maunuksela E-L. Clinical pharmacokinetics and pharmacodynamics of opioid analgesics in infants and children.
Clin Pharmacokinet. 1995; 28:385-404.
Suominen P, Olkkola KT, Voipio V, Korpela R, Palo R, Räsänen J. Utstein style reporting of in-hospital paediatric cardiopulmonary
resuscitation. Resuscitation. 2000; 45:17-25.
Saari TI, Laine K, Leino K, Valtonen M, Neuvonen PJ, Olkkola KT. Effect of voriconazole on the pharmacokinetics and pharmacodynamics of
intravenous and oral midazolam. Clin Pharmacol Ther. 2006; 79:362-370.
Liukas A, Kuusniemi K, Aantaa R, Virolainen P, Neuvonen M, Neuvonen PJ, Olkkola KT. Plasma concentrations of oral oxycodone are
greatly increased in the elderly. Clin Pharmacol Ther. 2008; 84:462-467.
Updated Nov-12
Contact details
Outi Paija
Dept of Oncology,
Turku University Hospital
PO BOX 52
FI-20520 Turku
Finland
MD, PhD
e-mail: [email protected]
phone: +358 2 3130000 / 52863
mobile: +358 40 5113194
fax: +358 2 3131839
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Oncology and Radiotherapy | 1996 | University of Turku
PhD | 2000 | University of Turku
MD | 1983 | University of Lund
Management and Administration of Health Care | 2001 | University of Turku
Medical Specialist | 1993-1995, 2003- | Dept of Oncology and Radiotherapy, Turku University
Hospital
Researcher | 1995-2000 | Oncology, Clinical pharmacology, Laboratory medicine
Head of clinical trials | 2000-2003 | CRST, University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research
experience
GCP training
Resources available for
clinical research
Clinical Pharmacology
Oncology: Breast Cancer
Clinical trials on medicinal products
Principal investigator Sub-investigator Person in charge of research (national trials)
in charge of research (international trials)
Person
Over 15 years
GCP -training and test / Pharmaceutical Information Centre
GCP web based test /
Pharmaceutical Information Centre GCP-training organised by a previous sponsor Clinical
Pharmacology and CRST
Study nurses, material and space available at the Dept of Oncology, Turku University Hospital.
Representative publications
Ahokoski O, Irjala K, Huupponen R, Halonen K, Salminen E, Scheinin H. Hormonal effects of MPV-2213ad, a new selective aromatase
inhibitor, in healthy male subjects. A phase I study. Br J Clin Pharmacol. 1998; 45:141–146.
Ahokoski O, Virtanen A, Kairisto V, Scheinin H, Huupponen R, Irjala K. Biological day-to-day variation and reference change limits of serum
cortisol and aldosterone in healthy young men on unrestricted diets. Clin Chem. 1999; 45:1097-1099.
Huupponen R, Paija O, Salonen M, Björklund H, Rouru J, Anttila M. Pharmacokinetics of deramciclane, a novel anxiolytic agent, after
intravenous and oral administration. Drugs R D. 2003; 4:339-345.
Ahokoski O, Irjala K, Taalikka M, Manninen P, Halonen K, Kangas L, et al. Pharmacokinetics of finrozole (MPV-2231ad), a novel selective
aromatase inhibitor, in healthy men. Br J Clin Pharmacol. 2001; 52:702–704.
Joensuu H, Kellokumpu-Lehtinen P-L, Huovinen R, Jukkola-Vuorinen A, Tanner M, Asola R, et al. Adjuvant capecitabine in combination with
docetaxel and cyclophosphamide plus epirubicin for breast cancer: a randomised prospective trial. Lancet Oncology. 2009; 10:1145-1151.
Updated Nov-12
Nanneli Pallasmaa
MD
Contact details
Turku University Hospital,
Department of Obstetrics and
Gynecology,
Kiinamyllynkatu 4-8, FI-20521
Turku, Finland
e-mail:
[email protected]
phone: +358 50 5639080
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Perinatology | 2008 | University of Turku
Specialist Degree in Obstetrics and Gynecology | 2002 | University of Turku
MD | 1987 | University of Tampere
Medical Specialist | 2002 - | Dept. Obstetrics and Gynecology, Turku University Hospital
Specialising in Perinatology | 2002 - 2008 | Dept. Obstetrics and Gynecology, Turku
University Hospital
Researcher | 2005 - | Dept. Obstetrics and Gynecology, Turku University Hospital
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Experience with
vulnerable study subjects
Total clinical research
experience
GCP training
Additional information
Obstetrics and Gynecology: Gynecology, Perinatology
Other medical research
Principal investigator
Observational trials
Person in charge of research (national trials)
Pregnant women / nursing mothers
0–5 years
GCP-training organised by a previous sponsor
Research area: Cesarean sections, obstetric practice, obstetric complications
Representative publications
Pallasmaa N, Ekblad U & Gissler M. Severe maternal morbidity and the mode of delivery. Acta Obstet Gynecol Scand 2008; 87: 662-668.
Pallasmaa N, Ekblad U, Aitokallio-Tallberg A et al. Cesarean delivery in Finland: maternal complications and obstetric risk factors. Acta
Obstet Gynecol Scand 2010; 89: 896-902.
Updated Nov-12
Contact details
Sirkku Peltonen
MD, PhD, Docent
Department of Dermatology,
Turku University Hospital
Po Box 52
FI-20521 Turku
Finland
e-mail: [email protected]
phone: +358 2 3132614
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Dermatology and Venereology | 2001 | University of Turku
PhD | 1991 | University of Turku
MD | 1991 | University of Turku
Chief Physician | 2004-2005 | Department of Dermatology, Turku University Hospital
Medical Specialist
Researcher | 1993-1994 | Dept. of Medical Biochemistry, University of Oulu
Researcher | 1987-1989 | Thomas Jefferson University, Philadelphia, USA
Professor | 2004-2005, 2009-2010| Dept. of Dermatology, University of Turku
Adjunct Professor / Docent | 1994 | University of Oulu
Adjunct Professor / Docent | 2000- | University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Dermatology: Dermatology
Other medical research
Representative publications
Peltonen S, Hentula M, Hägg, P, Rehn M, Lakkakorpi J, Ylä-Outinen, Pihlajaniemi T and Peltonen J. A novel component of epidermal cellmatrix and cell-cell contacts: Transmembrane protein type XIII collagen. J Invest Dermatol. 1999; 113:635-642.
Leinonen P, Hägg PM, Peltonen S, Jouhilahti E-M, Melkko J, Korkiamäki T, Oikarinen A and Peltonen J. Re-evaluation of the normal
epidermal calcium gradient, and analysis of calcium levels and ATP receptors in Hailey-Hailey and Darier epidermis. Journal of
Investigative Dermatology. 2009; 129:1379-1387.
Pummi K, Malminen M, Aho H, Karvonen S-L, Peltonen J, Peltonen S. Epidermal Tight Junctions: ZO-1 and Occludin are expressed in
mature, developing, and affected skin, and in vitro differentiating keratinocytes. J Invest Dermatol. 2001; 117:1050-1058.
Mahoney MG, Sadowski S, Brennan D, Pikander P, Saukko P, Wahl J, Aho H, Heikinheimo K, Bruckner-Tuderman L, Fertala A, Peltonen J,
Uitto J, Peltonen S. Compound heterozygous desmoplakin mutations result in a phenotype with a novel combination of myocardial, skin,
hair, and enamel abnormalities. J Invest Dermatol. 2010; 130:968-978.
Jouhilahti EM, Peltonen S, Callens T, Jokinen E, Messiaen L, Peltonen J. The development of the cutaneous neurofibromas. Am J Pathol.
2011; 178(2):500-505.
Updated Nov-12
Contact details
Mikko Pietilä
Cardiologist, MD, PhD
Dept of Internal Medicine,
Turku University Hospital
PO Box 52
FI-20521 Turku
Finland
e-mail: [email protected]
phone: +358 2 3130511
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Internal Medicine | 1999 | University of Turku
Specialist Degree in Cardiology | 2003 | University of Turku
PhD | 2002 | University of Turku
MD | 1993 | University of Turku
Medical Specialist | 2003- | Department of Internal Medicine, Cardiology, Turku University
Hospital
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research
experience
GCP training
Internal Medicine: Cardiology
Medical Imaging: PET, Invasive Cardiology
Clinical trials on medicinal products
Principal investigator
Clinical trials on medical devices
Sub-investigator
Observational trials
Person in charge of research (international trials)
Over 15 years
GCP-training organised by a previous sponsor
Resources available for
clinical research
Study nurse, facilities of the department of internal medicine, including cath labs.
Additional information
Acute coronary syndromes, heart failure.
Representative publications
Pietilä M, Malminiemi K, Ukkonen H, Voipio-Pulkki LM et al. Reduced myocardial carbon-11 retention is associated with poor prognosis in
chronic heart failure. Eur J Nucl Med. 2001; 28:373-376.
Kajader S, Joutsiniemi E, Saraste M, Pietilä M, Knuuti J et al. Cardiac PET/CT imaging accurately detects anatomically and functionally
significant coronary artery disease. Circulation. 2010; 122(6):603-613.
Niemelä M, Kervinen K, Pietilä M et al for the Nordic PCI study group. Randomized comparison of final kissing balloon dilatation versus
no kissing balloon dilatation in patients with coronary bifurcation lesions treated with main vessel stenting. 2011; 123:79-86.
Karjalainen P, Ylitalo A, Pietilä M, Airaksinen J et al. Two-year follow-up after percutaneous coronary intervention with titanium- nitrideoxide coated stent versus paclitaxel- eluting stents in acute myocardial infarction. Ann Med. 2009; 41(8):599-607.
Updated Nov-12
Contact details
Päivi Polo
(former Polo-Kantola)
MD, PhD, Docent
Dept Obstetrics and Gynaecology
Turku University Hospital
Kiinamyllynkatu 4-8
FI-20520 Turku
Finland
e-mail: [email protected]
phone: +358 2 3151305
mobile: +358 40 0583561
fax: +358 2 3132340
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Obstetrics and Gynaecology | 1998 | University of Turku
Specialist Degree in Perinatologist | 2001 | University of Turku
PhD | 1999 | University of Turku
MD | 1986 | University of Turku
Medical Specialist | 1998 | Dept. Obstetrics and Gynaecology, Turku University Hospital
Adjunct Professor / Docent | 2004 | Dept. Obstetrics and Gynaecology, University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Experience with
vulnerable study subjects
Total clinical research
experience
GCP training
Resources available for
clinical research
Additional information
Geriatrics: Cognition and Aging Neurology: Memory Disorders, Neurodegenerative Diseases,
Movement Disorders, Cognition
Neuropsychology
Obstetrics and Gynaecology:
Endocrinology, Gynaecology, Perinatology, Menopause Pulmonary Diseases: Sleep Disorders
Clinical trials on medicinal products
Other medical research
Observational trials
Principal investigator Sub-investigator Person in charge of research (national trials)
in charge of research (international trials)
Person
Pregnant women / nursing mothers
10–15 years
Clinical Investigator's Training / TurkuCRC and GSCS
Restricted use of a study nurse at the Sleep Research Unit.
My research is focused on the changes of sleep and cognition, especially among middle aged and
menopausal women. Research is now also being extended to pregnant women and male
populations. Additionally, other perinatological research is about to begin (e.g. hyperemesis
study).
Representative publications
Polo-Kantola P. et al. Estrogen replacement therapy and nocturnal periodic limb movements: A randomized controlled trial. Obstet Gynecol
2001; 97:548-554.
Polo-Kantola P. et al. Breathing during sleep in menopause: a randomized, controlled, cross-over trial with estrogen therapy. Obstet
Gynecol 2003; 102:68-75.
Karakorpi M,..Polo-Kantola, et al. Hormone treatment gives no benefit against cognitive changes caused by acute sleep deprivation in
postmenopausal women. Neuropsychopharmacology 2006; 31:2079-2088.
Alhola P, Polo-Kantola et al. Estrogen therapy and cognition: A 6-years single-blind follow-up study in postmenopausal women. Neurology
2006; 67:706-709.
Kalleinen N, Polo-Kantola P, et al. 24-Hour serum levels of growth hormone, prolactine and cortisol in pre- and postmenopausal women:
the effect of combinest estrogen-progestin threatment. J Clin Endocrin Metab 2008; 93:1655-1661.
Updated Nov-12
Contact details
Kari Remes
M.D., Ph.D., Professor
Department of Internal
Medicine, Turku University
Hospital
PO Box 52, 20521 Turku
e-mail: [email protected]
phone: +358 2 3130016
mobile: +358 40 5017748
fax: +358 2 3133043
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Internal Medicine | 1983 | University of Helsinki
Specialist Degree in Clinical Haematology | 1985 | University of Helsinki
PhD | 1979 | University of Helsinki
MD | 1975 | University of Helsinki
Chief Physician | 2000 - | Department of Internal Medicine, Turku University Hospital
Medical Specialist | 1988 - 1999 | Senior Clinical Haematologist, Turku University Hospital
Professor | 2011 - | Department of Internal Medicine, Turku University Hospital
Director | 1994 - 2010 | Bone Marrow Transplantation Programme
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research
experience
GCP training
Resources available for
clinical research
Additional information
Internal Medicine: Haematology, haematopoietic stem cell transplantations
Clinical trials on medicinal products
Principal investigator
Other medical research
Observational trials
Person in charge of research (international trials)
Over 15 years
GCP -training and test / Pharmaceutical Information Centre (October 2009)
Research nurse.
Clinical studies in the field of hematopoietic stem cell transplantation; studies on
treatments for multiple myeloma.
Representative publications
Remes K, Itälä M, Kauppila M, et al. Autologous blood cell transplantation in multiple myeloma: impact of CD34+ cell selection with long
follow-up. J Hematother Stem Cell Res 2003; 12:63-70.
Putkonen M, Rauhala A, Itälä M, Kauppila M, Pelliniemi T-T, Remes K. Double vs single autotransplantation in multiple myeloma; a single
center experience of 100 patients. Haematologica/Hematology J 2005;90:562-3
Ruutu T, Eriksson B, Remes K, et al. Ursodeoxycholic acid for the prevention of hepatic complications in allogeneic stem cell
transplantation. Blood 2002; 100:1977-83.
Putkonen M, Kairisto V, Juvonen V, Remes K, et al. Depth of response asessed by quantitative ASO-PCR predicts the outcome after stem
cell transplantation in multiple myeloma. Eur J Haematol 2010; 85:416-23.
Itälä M, Remes K, et al. Stem cell transplantation in poor-risk chronic lymphocytic leukemia: assessment of post-transplant minimal
residual disease using four- and six-color flow cytometry and allele-specific RQ-PCR. Eur J Haematol 2008; 81:100-6.
Updated Nov-12
Contact details
Turku PET Centre,
University of Turku and Turku
University Hospital,
Kiinamyllynkatu 4-8, 20520
Turku, Finland
Juha Rinne
Professor, MD, PhD
e-mail: [email protected]
web: www.turkupetcentre,fi
phone: +358 2 3131866
fax: +358 2 2318191
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Neurology | 1993 | University of Turku
PhD | 1987 | University of Turku
MD | 1985 | University of Turku
Medical Specialist | 1993 - 2000 | Dept. of Neurology, Turku University Hospital
Specialising Physician | 1989 - 1993 | Dept. of Neurology, Turku University Hospital
Professor | 1999 -2003, 2007 - | Turku PET Centre, University of Turku
Adjunct Professor / Docent | 2004 - 2006 | Turku PET Centre, University of Turku
Research fellow | 1992 - 1993 | The National Hospital for Neurology, Queen Square, London
UK
Research fellow | 1992 - 1993 | MRC Cyclotron and PET unit, Hammersmith hospital, London
UK
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Experience with
vulnerable study subjects
Total clinical research
experience
GCP training
Medical Imaging: Nuclear Medicine, PET
Diseases, Movement Disorders
Clinical trials on medicinal products
Neurology: Memory Disorders, Neurodegenerative
Other medical research
Observational trials
Principal investigator Person in charge of research (national trials)
research (international trials)
Person in charge of
Persons not able to give consent
Over 15 years
GCP web based test / Pharmaceutical Information Centre
previous sponsor
GCP-training organised by a
Representative publications
Bäckman L, Nyberg L, Soveri A, Johansson J, Andersson M, Dahlin E, Neely AS, Virta J, Laine M, Rinne JO. Effects of working-memory
training on striatal dopamine release. Science. 2011;333(6043):718.
Rinne JO, Brooks DJ, et al. 11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated
with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study. Lancet Neurol. 2010;9(4):363-72.
Mosconi L, Rinne JO, Tsui WH, Berti V, Li Y, Wang H, et al. Increased fibrillar amyloid-{beta} burden in normal individuals with a family
history of late-onset Alzheimer's. Proc Natl Acad Sci USA. 2010;107(13):5949-54.
Scheinin NM, Aalto S, Koikkalainen J, Lötjönen J, Karrasch M, Kemppainen N, Viitanen M, Någren K, Helin S, Scheinin M, Rinne JO. Followup of [11C]PIB uptake and brain volume in patients with Alzheimer disease and controls. Neurology. 2009;73(15):1186-92.
Aalto S, et al. Frontal and temporal dopamine release during working memory and attention tasks in healthy humans – a positron
emission tomography study using high affinity dopamine D2 receptor ligand [11C]FLB 457. Journal of Neuroscience. 2005;25:2471-2477.
Updated Nov-12
Contact details
Marjut Rintala
Dept of Obstetrics and
Gynaecology,
Turku University Hospital
PO Box 52
FI-20520 Turku
Finland
MD, PhD
e-mail: [email protected]
phone: +358 2 3130659
fax: +358 2 3132340
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Obstetrics and Gynaecology | 2002 | University of Turku
Specialist Degree in Gynaecologic Oncology | 2008 | University of Turku
PhD | 2006 | University of Turku
Medical Specialist | 2002| Dept of Obst and Gyn, Turku University Hospital
Clinical Teacher | 2008| Dept of Obstet and Gyn, University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Experience with vulnerable
study subjects
Total clinical research
experience
Obstetrics and Gynaecology: Gynaecology, HPV, Oncology
Paediatrics: HPV
Other medical research
Principal investigator
Minors
Sub-investigator
Pregnant women / nursing mothers
10–15 years
Representative publications
Rintala MA, Grénman SE, Järvenkylä ME, Syrjänen KJ, Syrjänen SM. High-risk types of human papillomavirus (HPV) DNA in oral and genital
mucosa of infants during their first three years of life. Clin Infect Dis. 2005; 41(12):1728-1733.
Rintala MA, Pöllänen PP, Nikkanen VP, Grénman SE, Syrjänen SM. Human papillomavirus DNA is found in the vas deferens. J Infect Dis.
2002; 185(11):1664-1667.
Louvanto K, Rintala MA, Syrjänen KJ, Grénman SE, Syrjänen SM. Genotype-specific persistence of genital human papillomavirus (HPV)
infections in women followed for six years. J Infect Dis. 2010; 202(3):436-444.
Rintala MA, Grénman SE, Puranen MH, Isolauri E, Ekblad U, Kero PO, Syrjänen SM. Transmission of high-risk human papillomavirus (HPV)
between parents and infan. J Clin Microbiol. 2005; 43(1):376-381.
Louvanto K, Syrjänen KJ, Rintala MA, Grénman SE, Syrjänen SM. Genotype-specific clearance of genital human papillomavirus (HPV)
infections among mothers in the Finnish Family HPV Study. J Clin Mcrobiol. 2010; 48(8):2665-2671.
Updated Nov-12
Contact details
Anne Roivainen
Professor
Turku PET Centre,
University of Turku and
Turku University Hospital
Kiinamyllynkatu 4-8
FI-20520 Turku
Finland
e-mail: [email protected]
web page: www.pet.fi
phone: +358 2 3132862
mobile: +358 40 8243510
fax: +358 2 2318191
Curriculum Vitae
Degrees
Current and relevant
previous positions
PhD | 1998 | University of Turku
MSc | 1990 | University of Kuopio
Professor | 2011- | Turku PET Centre , University of Turku
Adjunct Professor / Docent | 2004 | Experimental Nuclear Medicine, University of Turku
Academy Research Fellow | 2007-2012 | Academy of Finland/University of Turku
Post-Doc Research Fellow | 2004-2006 | Academy of Finland/Turku University Hospital
Post-Doc Research Fellow | 2002-2003 | Finnish Cancer Institute
Researcher | 1998-2002 | Turku PET Centre , Turku University Hospital
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research
experience
GCP training
Resources available for
clinical research
Medical Imaging: Nuclear Medicine, PET
Other medical research
Principal investigator
5–10 years
GPP = Good PET Practice
Resources of PET Centre (physicists, chemists, nurses, laboratory technicians, cameras, etc).
Representative publications
Lankinen P, Mäkinen TJ, Pöyhönen TA, Virsu P, Salomäki S, Hakanen AJ, Jalkanen S, Aro HT, Roivainen A. (68)Ga-DOTAVAP-P1 PET
imaging capable of demonstrating the phase of inflammation in healing bones and the progress of infection in osteomyelitic bones. Eur J
Nucl Med Mol Imaging. 2008; 35(2):352-364.
Roivainen A, Tolvanen T, Salomäki S, Lendvai G, Velikyan I, Numminen P, Välilä M, Sipilä H, Bergström M, Härkönen P, Lönnberg H,
Långström B. 68Ga-labeled oligonucleotides for in vivo imaging with PET. J Nucl Med. 2004; 45(2):347-355.
Roivainen A, Parkkola R, Yli-Kerttula T, Lehikoinen P, Viljanen T, Möttönen T, Nuutila P, Minn H. Use of positron emission tomography
with methyl-11C-choline and 2-18F-fluoro-2-deoxy-D-glucose in comparison with magnetic resonance imaging for the assessment of
inflammatory proliferation of synovium. Arthritis Rheum. 2003; 48(11):3077-3084.
Ujula T, Huttunen M, Luoto P, Peräkylä H, Simpura I, Wilson I, Bergman M, Roivainen A. Matrix metalloproteinase 9 targeting peptides:
syntheses, 68Ga-labeling, and preliminary evaluation in a rat melanoma xenograft model. Bioconjug Chem. 2010; 21(9):1612-1621.
Haukkala J, Laitinen I, Luoto P, Iveson P, Wilson I, Karlsen H, Cuthbertson A, Laine J, Leppänen P, Ylä-Herttula S, Knuuti J, Roivainen A.
(68)Ga-DOTA-RGD peptide: biodistribution and binding into atherosclerotic plaques in mice. Eur J Nucl Med Mol Imaging. 2009; 36:2058–
2067.
Updated Nov-12
Contact details
Aino Ruohola
MD, PhD
Dept. of Paediatrics,
Turku University Hospital
PL 52
FI-20521 Turku
Finland
e-mail: [email protected]
web page:
www.korvatulehdustutkimus.fi
(only in Finnish)
mobile: +358 40 7387358
fax: +358 2 3131460
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Paediatrics | 2003 | University of Turku
PhD | 2001 | University of Turku
MD | 1990 | University of Turku
Medical Specialist | 2010 | Department of Paediatrics, Turku University Hospital
Researcher | 2005- | Department of Paediatrics, Turku University Hospital
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Experience with
vulnerable study subjects
Total clinical research
experience
GCP training
Paediatrics
Clinical trials on medicinal products
Principal investigator
Other medical research
Observational trials
Study Physician
Minors
10–15 years
Clinical Investigator's Training / TurkuCRC and GSCS
GCP training / University of Helsinki
Representative publications
Tähtinen PA, Laine MK, Huovinen P, Jalava J, Ruuskanen O, Ruohola A. A placebo-controlled trial of antimicrobial treatment of acute
otitis media. N Eng J Med. 2011; 364:116-126.
Laine MK, Tähtinen PA, Ruuskanen O, Huovinen P, Ruohola A. Symptoms or symptom-based scores cannot predict acute otitis media at
otitis-prone age. Pediatrics. 2010; 125:e1154-1161.
Ruohola A, Waris M, Allander T, Ziegler T, Heikkinen T, Ruuskanen O. Viral etiology of common cold in children. Emerg Infect Dis. 2009;
15:344-346.
Ruohola A, Meurman O, Nikkari S, et al. Microbiology of acute otitis media in children with tympanostomy tubes: prevalences of bacteria
and viruses. Clin Infect Dis. 2006; 43:1417-1422.
Ruohola A, Heikkinen T, Meurman O, Puhakka T, Lindblad N, Ruuskanen O. Antibiotic treatment of acute otorrhea through
tympanostomy tube: randomized double-blind placebo-controlled study with daily follow-up. Pediatrics. 2003; 111:1061-1067.
Updated Nov-12
Contact details
Dept of Pulmonary Diseases, Turku
University Hospital, PO Box 52, FI-20521
Turku, Finland
Sleep Research Unit, University of Turku,
Lemminkäisenkatu 14-18 A 5th Floor, FI20520 Turku, Finland
Tarja Saaresranta
MD, PhD, Docent
e-mail: [email protected]
web page: http://www.med.utu.fi
/sivustot/unitutkimus/en
phone: +358 2 3130000
mobile: +358 40 7401149
fax: +358 2 2410057
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Respiratory Allergology | 2005 | University of Turku
Specialist Degree in Administration | 2005 | University of Turku
Special Competence in Sleep Medicine | 2001 | Finnish Medical Association
PhD | 2000 | University of Turku
Specialist Degree in Pulmonary Medicine | 1993 | University of Turku
MD | 1986 | University of Turku
Chief Specialist | 2007- | Dept. of Pulmonary Diseases, Turku University Hospital
Associate Chief Physician | 2006-2007| Dept. of Pulmonary Diseases, Turku University Hospital
Medical Specialist | 1994-2006 | Dept. of Pulmonary Diseases, Satalinna Hospital and Turku
University Hospital
Chief Physician | 1993-1994 | Dept. of Pulmonary Diseases, Kuusankoski District Hospital
Specialising Physician | 1990-1993 | Dept. of Pulmonary Diseases, Turku University Hospital
Professor | 2010 | Dept. of Pulmonary Diseases and Clinical Allergology, University of Turku
Adjunct Professor / Docent | 2005- | Dept. of Pulmonary Diseases and Clinical Allergology,
University of Turku
Associate Director | 2004- | Sleep Research Unit, University of Turku
Researcher | 2002-2003 | Dept. of Medicine, University of Chicago
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research
experience
GCP training
Neurology: Movement Disorders
Clinical trials on medicinal products
Principal investigator
Pulmonary Diseases: Sleep Disorders, Respiratory Failure
Other medical research
Sub-investigator
Observational trials
Person in charge of research (national trials)
10–15 years
GCP web based test / Pharmaceutical Information Centre
sponsor
GCP-training organised by a previous
Resources available for
clinical research
No staff funded by the University or Hospital. One sleep technician and one research nurse funded
by our research group. Fully equipped sleep laboratory with two beds and facilities for overnight
blood sampling etc.
Additional information
Special interest sleep-disordered breathing, menopause and comorbidity. Participated in clinical
trials on insomnia and RLS.
Representative publications
Anttalainen U, Polo O, Vahlberg T, Saaresranta T. Reimbursed drugs in patients with sleep-disordered breathing - a static-charge-sensitive bed study. Sleep
Med. 2010; 11:49-55.
Aittokallio J, Saaresranta T, Virkki A, Karppinen N, Heinonen O, Aittokallio T, Polo O. Transcutaneous carbon dioxide profile during sleep reveals metabolic risk
factors in postmenopausal women. Eur Respir J. 2009; 34:1132-1139.
Saaresranta T, Polo-Kantola P, Polo O. Menopausal insomnia. s. 117 – 36. In: Attarian H, Schuman C (eds.). Clinical Handbook of Insomnia. 2. ed. 362 p. Springer:
Humana Press, USA, 2010.
Saaresranta T, Polo O. Sleep-disordered breathing and hormones. Eur Respir J. 2003; 22:161–172.
Saaresranta T, Polo-Kantola P, Irjala K, Helenius H, Polo O. Respiratory insufficiency in postmenopausal women: sustained improvement with short-term
medroxyprogesterone acetate. Chest. 1999; 115:1581-1587.
Updated Nov-12
Teijo Saari
MD, PhD
Contact details
Department of
Anaesthesiology, Intensive
Care, Emergency Care and Pain
Medicine;
University of Turku and
Turku University Hospital
PO Box 52 (Kiinamyllynkatu 48)
FI-20521 Turku
Finland
e-mail: [email protected]
phone: +358 2 3130596
mobile: +358 40 7314041
fax: +358 2 3133960
Curriculum Vitae
Degrees
Current and relevant previous
positions
Specialist Degree in Anaesthesiology and Intensive Care | 2006 | University of
Turku
PhD | 2007 | University of Turku
MD | 2000 | University of Turku
Post Doctoral Researcher | 2011-| Friedrich-Alexander-Universität
Erlangen-Nürnberg, Anästhesiologische Klinik
Medical Specialist | 2006-2010 | Department of Anaesthesiology, Intensive Care,
Emergency Care and Pain Medicine, Turku University Hospital
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research experience
GCP training
Anaesthesiology and Intensive Care: Anaesthesiology, Emergency Medicine,
Intensive Care, Pain Relief Clinical Pharmacology
Clinical trials on medicinal products
Principal investigator
Sub-investigator
5–10 years
Clinical Investigator's Training / TurkuCRC and GSCS
Resources available for clinical
research
*Our research group has collaborated with the Department of Pharmacology,
Drug Development and Therapeutics, University of Turku. The Department has
excellent facilities for clinical drug research.
Additional information
*Research interests: Drug Interaction Studies, Population Pharmacokinetic and dynamic Analysis, Modelling and Simulation, Statistical Analysis.
*Researcher in Clinical Drug research Graduate School research group supervised
by prof. Klaus Olkkola.
Representative publications
Saari TI, Laine K, Leino K, Valtonen M, Neuvonen PJ, Olkkola KT. Effect of voriconazole on the pharmacokinetics and pharmacodynamics
of intravenous and oral midazolam. Clin Pharmacol Ther. 2006; 79:362–70.
Peltoniemi M, Saari TI, Hagelberg N, Reponen P, Turpeinen M, Laine K, Neuvonen PJ, Olkkola KT. Exposure to oral S-ketamine is
unaffected by itraconazole, but greatly increased by ticlopidine, Clin Pharmacol Ther. 2011; 90:296–302.
Saari TI, Ihmsen H, Neuvonen PJ, Olkkola KT, Schwilden H. Oxycodone clearance is markedly reduced with advancing age. A population
pharmacokinetic study. Br J Anaesth. 2012; 108:491-8.
Jeleazcov C, Saari TI, Ihmsen H, Schüttler J, Fehner J. Changes in total and unbound concentrations of sufentanil during target controlled
infusion for cardiac surgery with cardiopulmonary bypass. Br J Anaesth, doi: 10.1093/bja/aes253 [Epub ahead of print].
Saari TI, Fehner J, Ihmsen H, Schüttler J, Jeleazcov C. Quantitation of total and unbound fraction of hydromorphone and
norhydromorphone in human plasma with ultrafiltration, solid-phase extraction and liquid chromatography/mass spectrometry. J
Pharmaceut Biomed Anal, doi: 10.1016/j.jpba.2012.07.025 [Epub ahead of print]
Updated Nov-12
Contact details
Simo Saarijärvi
Professor
Psychiatry and adolescent
psychiatry,
University of Turku and
Turku University Hospital
Kaskenkatu 18 A 3
FI-20700 Turku
Finland
e-mail:
[email protected]
mobile: +358 40 5866059
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Psychiatry | 1989 | University of Turku
Specialist Degree in Adolescent psychiatry| 1999 | University of Turku
PhD | 1991 | University of Turku
MD | 1981 | University of Tampere
Chief Physician | 1997- | Unit of adolescent psychiatry, Turku University Hospital
Professor | 1997- | Psychiatry and adolescent psychiatry, University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Experience with vulnerable
study subjects
Total clinical research
experience
Psychiatry: Adolescents, Adults
Clinical trials on medicinal products
Principal investigator
Other medical research
Observational trials
Person in charge of research (national trials)
Minors
Over 15 years
Representative publications
Karukivi M, Hautala L, Korpelainen J, Haapasalo-Pesu KM, Liuksila P-R, Joukamaa M, Saarijärvi S. Alexithymia and eating disorder
symptoms in adolescents. Eat Disord. 2010; 18:226-38.
Karukivi M, Hautala L, Kaleva O, Haapasalo-Pesu KM, Liuksila PR, Joukamaa M, Saarijärvi S. Alexithymia is associated with anxiety among
adolescents. J Affect Disord. 2010; 125:383-87.
Karukivi M, Joukamaa M, Hautala L, Kaleva O, Haapasalo-Pesu KM, Liuksila PR, Saarijärvi S. Does perceived social support and parental
attitude relate to alexithymia? A study in Finnish late adolescents. Psychiatry Res. 2011; 187:254-60.
Hautala L, Helenius H, Karukivi M, Maunula A-M, Nieminen J, Aromaa M, Liuksila P-R, Räihä H, Välimäki M, Saarijärvi S. The role of
gender, affectivity and parenting in the course of disordered eating: a 4-year prospective case-control study of adolescents. Int J Nurs
Stud. 2011; 8:959-72.
Karukivi M, Joukamaa M, Hautala L, Kaleva O, Haapasalo-Pesu KM, Liuksila PR, Saarijärvi S. Deficit in speech development at the age of 5
years predicts alexithymia in late-adolescent males. Compr Psychiatry. 2012; 53(1):54-62
Updated Nov-12
Contact details
Harry Scheinin
Docent
Omnicon Oy
Auvaisbergin rantatie 93
FI-20760 Piispanristi
Finland
e-mail: [email protected]
phone: +358 40 0825599
mobile: +358 40 0825599
Curriculum Vitae
Degrees
Current and relevant
previous positions
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Experience with
vulnerable study subjects
Total clinical research
experience
GCP training
Resources available for
clinical research
Specialist Degree in Clinical Pharmacology | 1995 | University of Turku
Specialist Degree in Anaesthesiology | 1997 | University of Turku
PhD | 1986 | University of Turku (Pharmacology)
MD | 1983 | University of Turku
Special competence in Pharmaceutical Medicine| 1997 | Finnish Medical Association
Medical Specialist | 1997-1999 | Dept. of Anaesthesiology, Intensive Care, Emergency Care and
Pain Medicine, Turku University Hospital
Specialising Physician | 1992-1997 | Turku University Hospital
Researcher | 1994-1995 | Karolinska Institute, Huddinge Hospital, Sweden
Professor | 1999-2007 | Turku PET Centre, University of Turku
Adjunct Professor / Docent | 1991- | Dept. of Pharmacology, Drug Development and
Therapeutics, University of Turku
Medical Director | 1986-1992 | Farmos/Orion
Anaesthesiology and Intensive Care: Anaesthesiology, Intensive Care, Pain Relief
Clinical
Pharmacology Internal medicine: Cardiology Medical Imaging: PET Neurology: Chronic Pain
Orthopaedics and Traumatology: Traumatology
Pulmonary Diseases: Sleep Disorders
Surgery: Cardiothoracic Surgery, Vascular Surgery
Clinical trials on medicinal products
Clinical trials on medical devices
Principal investigator Sub-investigator
responsibility of IND projects
Other medical research
Person in charge of research (national trials)
Overall
Persons not able to give consent
Over 15 years
GCP-training organised by a previous sponsor
6 years' experience of working in a pharmaceutical company
I am currently doing clinical work only in the private sector but could participate in research
projects carried out in Turku University Hospital or University of Turku upon separate agreement.
Representative publications
Scheinin H, Jaakola M-L, Sjövall S, Ali-Melkkilä T, Kaukinen S, Turunen J, Kanto J. Intramuscular dexmedetomidine as premedication for
general anesthesia - a comparative multicenter study. Anesthesiology. 1993; 78:1065-1075.
Wilson AJ, Diemunsch P, Lindeque BG, Scheinin H, Helbo-Hansen HS, Kroeks MVAM, Kong KL. Single-dose i.v. granisetron in the prevention of
postoperative nausea and vomiting. Brit J Anaesth. 1996; 76:515-518.
Laitio TT, Huikuri HV, Kentala ESH, Mäkikallio TH, Jalonen JR, Helenius H, Sariola-Heinonen K, Yli-Mäyry S, Scheinin H. Correlation properties
and complexity of perioperative RR-interval dynamics in coronary artery bypass surgery patients. Anesthesiology. 2000; 93:69-80.
Ingman K, Hagelberg N, Aalto S, Någren K, Juhakoski A, Karhuvaara S, Kallio A, Oikonen V, Hietala J, Scheinin H. Prolonged central mu-opioid
receptor occupancy after single and repeated nalmefene dosing. Neuropsychopharmacol. 2005; 30:2245-2253.
Laitio RM, Kaisti KK, Långsjö JW, Aalto S, Salmi E, Maksimow A, Aantaa R, Oikonen V, Sipilä H, Parkkola R, Scheinin H. Effects of xenon
anesthesia on cerebral blood flow in humans – a positron emission tomography study. Anesthesiology. 2007; 106:1128-1133.
Updated Nov-12
Contact details
Mika Scheinin
Professor, MD, PhD
CRST and Department of
Pharmacology, Drug
Development and Therapeutics,
University of Turku
Itäinen Pitkäkatu 4 B
(PharmaCity, 3rd floor),
FI-20014 University of Turku
Finland
e-mail: [email protected]
web page: www.crst.fi
phone: +358 2 3337502
mobile: +358 40 5014762
fax: +358 2 2510046
Curriculum Vitae
Degrees
Current and relevant previous
positions
PhD | 1984 | University of Turku
MD | 1977 | University of Turku
Chief Physician | 1996- | Unit of Clinical Pharmacology
Professor | 1995- | Pharmacology and Clinical Pharmacology, University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Anaesthesiology and Intensive Care: Anaesthetic Pharmacology
Clinical
Pharmacology Geriatrics: Drugs to treat Alzheimer's disease Internal Medicine:
Cardiovascular pharmacology Medical Imaging: Imaging in drug development, PET
Neurology: Neuropharmacology Psychiatry: Psychopharmacology
Clinical trials on medicinal products
medical research
Principal investigator
trials)
Clinical trials on medical devices
Sub-investigator
Experience with vulnerable study
subjects
Persons not able to give consent
Total clinical research experience
Over 30 years
Person in charge of research (national
GCP training
Extensive experience in GCP education and clinical trials
Resources available for clinical
research
Several study nurses and two 8-bed wards are available.
Additional information
Other
Director of a GCP-qualified phase I unit, Clinical Research Services Turku (CRST, see
www.crst.fi).
Representative publications
Iirola T et al. Dexmedetomidine inhibits gastric emptying and oro-caecal transit in healthy volunteers. Brit J Anaesth. 2011; 106:522-527.
Posti JP et al. Dorsal hand vein responses to the 1-adrenoceptor agonist phenylephrine do not predict responses to the 2-adrenoceptor
agonist dexmedetomidine. Eur J Pharmacol. 2011; 653:70-74.
Scheinin NM et al. Follow-up of [11C]PIB uptake and brain volume in patients with Alzheimer disease and controls. Neurology. 2009;
73:1186-1192.
Hirvonen J et al. Assessment of MAO-B occupancy in brain with PET and [11C]-L-deprenyl-D2: A dose-finding study with a novel MAO-B
inhibitor, EVT 301. Clin Pharmacol Ther. 2009; 85:506-512.
Snapir A et al. The effects of low and high plasma concentrations of dexmedetomidine on myocardial perfusion and cardiac function in
healthy male subjects. Anesthesiology. 2006; 105:902-910.
Updated Nov-12
Contact details
Department f Neurology,
University of Turku
Kiinamyllynkatu 4-8, PL 52
FI-20521 Turku
Finland
Merja Soilu-Hänninen
MD, PhD, Docent
e-mail: [email protected]
phone: +350 2 3131720
mobile: +358 40 7625515
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Neurology | 2001 | University of Turku
PhD | 1997 | University of Turku
MD | 1988 | University of Turku
Chief Specialist | 2009-2010 | Dept of Neurology, University of Turku
Medical Specialist | 2005- | Dept of Neurology, University of Turku
Professor | 1.9.-31.1.2010 | Dept of Neurology, University of Turku
Adjunct Professor / Docent | 2008- | Dept of Neurology, University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research
experience
GCP training
Neurology: Epilepsy, Neuroimmunological Diseases, Sleep Disorders
Clinical trials on medicinal products
Principal investigator
Other medical research
Observational trials
Sub-investigator
10–15 years
GCP-training organised by a previous sponsor
Resources available for
clinical research
The Department of Neurology has one full-time research assistant and one full time
research nurse.
Additional information
I have worked as a Principal Investigator and as an Investigator in several clinical MS-trials
and one epilepsy trial since 1996.
Representative publications
Soilu-Hänninen M, Koskinen JO, Laaksonen M, Hänninen A, Lilius EM, Waris M. High sensitivity measurement of CRP and disease
progression in multiple sclerosis. Neurology. 2005; 65(1):153-155.
Butzkueven H, Zhang JG, Soilu-Hänninen M et al. LIF receptor signalling limits immune-mediated demyelination by enhancing
oligodendrocyte survival. Nat Med. 2002; 8:613-619.
Soilu-Hänninen M, Airas L, Mononen I, Heikkilä A, Viljanen M, Hänninen A. 25-Hydroxyvitamin D levels in serum at the onset of multiple
sclerosis. Multiple Sclerosis. 2005; 11:266-271.
Soilu-Hänninen M, Laaksonen M, Laitinen I et al. A longitudinal study of serum 25-hydroxyvitamin D and intact PTH levels in multiple
sclerosis. JNNP. 2008; 79:152-157.
Radue EW, Stuart WH, Calabresi PA, et al. SENTINEL Investigators. Natalizumab plus interferon beta-1a reduces lesion formation in
relapsing multiple sclerosis. J Neurol Sci. 2010; 292(1-2):28-35.
Updated Nov-12
Contact details
Department of Internal
Medicine, Turku University
Hospital
Kiinamyllynkatu 4-8
FI-20520 Turku
Finland
Jan Sundell
Ph.D., Adjunct Professor
e-mail: [email protected]
phone: +358 2 3130000
mobile: +358 407759197
fax: +358 2 2318191
Curriculum Vitae
Degrees
Current and relevant previous
positions
Specialist Degree in Internal Medicine | 2005 | University of Turku
Adjunct Professor | 2006 | Department of Internal Medicine, University of Turku
PhD | 2002 | University of Turku
MD | 1997 | University of Turku
Chief Physician | 2010 - | Department of Internal Medicine, Turku University Hospital
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research experience
GCP training
Resources available for clinical
research
Internal Medicine: Cardiology, Endocrinolog,
training Nutrition
Medical Imaging: PET
Resistance
Clinical trials on medicinal products
medical research
Clinical trials on medical devices
Principal investigator
Person in charge of research (national trials)
Sub-investigator
Other
10–15 years
Clinical Investigator's Training / TurkuCRC and GSCS
Turku PET Centre resources available and the facilities of the department of internal
medicine.
Representative publications
Sundell J, Nuutila P, Laine H, Luotolahti M, Kalliokoski K, Raitakari O et al. Dose-dependent vasodilating effects of insulin on adenosinestimulated myocardial blood flow. Diabetes 2002;51:1125-1130.
Sundell J, Janatuinen T, Ronnemaa T, Raitakari OT, Toikka J, Nuutila P, Knuuti J. Diabetic background retinopathy is associated with
impaired coronary vasoreactivity in people with Type 1 diabetes. Diabetologia 2004;47(4):725-31.
Sundell J, Engbom E et al. The effects of cardiac resynchronization therapy on left ventricular function, myocardial energetics and
metabolic reserve in patients with dilated cardiomyopathy and heart failure. J Am Coll Cardiol 2004;43(6):1027-33.
Sundell J, Laine H, Raitakari OT, Luotolahti M, Nuutila P, Viikari J et al. Increased lipoprotein(a) is associated with reduced myocardial
vasoreactivity in young healthy men. Atherosclerosis 2005; 179(1):185-191
Sundell J. Resistance training is an effective tool against metabolic and frailty syndromes. Advances in Preventive Medicine 2011; Article
ID 984683.
Updated Nov-12
Contact details
Jari Sundström
Docent
Department of Pathology,
University of Turku
Kiinamyllynkatu 10, 20520
Turku Finland
e-mail: [email protected]
phone: +358 2 313 1694
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Pathology | 2005 | University of Turku
PhD | 2000 | University of Turku
MD | 1993 | University of Turku
Special competence in medical education | 2011 | University of Turku
Docent | 2011 | Department of Pathology | University of Turku
University Teacher | 2006- | Department of Pathology | University of Turku
Medical Specialist | Department of Pathology | University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research
experience
Pathology : Colorectal cancer, Nephropathology
Other medical research
Supervisor of doctoral theses
5–10 years
Representative publications
Korkeila E, Talvinen K, Jaakkola PM, Minn H, Syrjänen K, Sundström J, Pyrhönen S. Expression of carbonic anhydrase IX suggests poor
outcome in rectal cancer. British Journal of Cancer 2009;100:874-880.
Korkeila E, Syrjänen K, Bendardaf R, Laulajainen M, Carpén O, Pyrhönen S and Sundström J. Preoperative radiotherapy modulates ezrin
expression and its value as a predictive marker in patients with rectal cancer. Human Pathology. 2011; 42(3):384-392.
Korkeila E, Jaakkola PM, Syrjänen K, Sundström J, Pyrhönen S. Preoperative radiotherapy downregulates the nuclear expression of
hypoxia-inducible factor 1 in rectal cancer. Scandinavian Journal of Gastroenterology 2010;45:340-348.
Ojala P, Sundström J, Grönroos JM, Virtanen E, Talvinen K, Nevalainen TJ. mRNA differential display of gene expression in colonic
carcinoma. Electrophoresis 2002;23:1667-1676.
Sundström J, Pelliniemi LJ, Kuopio T, Veräjänkorva E, Fröjdman K, Harley V, Salminen E, Pöllänen P. Characterization of the model for
experimental testicular teratoma in 129/SvJ-mice. British Journal of Cancer 1999;80:149-160.
Updated Nov-12
Contact details
Olli Tenovuo
Docent
Department of Neurology,
Turku University Hospital
Kiinamyllynkatu 4-8
FI-20520 Turku
Finland
e-mail: [email protected]
mobile: +358 50 4383802
fax: +358 2 3132737
Curriculum Vitae
Degrees
PhD | 1992 | University of Turku
MD | 1981 | University of Turku
Special competence in pain medicine | 2000
Special competence in rehabilitation | 2004
Associate Chief Physician | 1998-2002 | Department of Neurology, Turku
University Hospital
Medical Specialist | 1993-1998 | Department of Neurology, Turku University
Hospital
Adjunct Professor / Docent | 2005- | University of Turku
Current and relevant previous
positions
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research experience
Resources available for clinical
research
Additional information
Anaesthesiology and Intensive Care: Pain Relief Oral Diseases: Facial Pain
Neurology: Brain Injuries Neurological Rehabilitation
Clinical trials on medicinal products
Principal investigator
Other medical research
Observational trials
Sub-investigator
Over 15 years
Study nurse, ten PhD students, > 20 senior researchers from nine specialties
involved.
Leader of a multidisciplinary research team on traumatic brain injuries, including
currently international trials.
Representative publications
Koponen S, Taiminen T, Portin R, Himanen L, Isoniemi H, Heinonen H, Hinkka S, Tenovuo O. Axis I and II psychiatric disorders after
traumatic brain injury: a 30-year follow-up study. Am J Psychiatry. 2002; 159:1315-1321.
Himanen L, Portin R, Isoniemi H, Helenius H, Kurki T, Tenovuo O. Longitudinal cognitive changes in traumatic brain injury: a 30 year
follow-up study. Neurology. 2006; 66:187-192.
Isoniemi H, Kurki T, Portin R, Kairisto V, Tenovuo O. Hippocampal volume, brain atrophy, and ApoE genotype after traumatic brain injury.
Neurology. 2006; 67:756-760.
Laalo J, Kurki T, Tenovuo O, Sonninen P. Reliability of diagnosis of traumatic brain injury by computed tomography in acute phase. J
Neurotrauma. 2009; 26:2169-2178.
Östberg A, Virta J, Rinne JO, Oikonen V, Luoto P, Någren K, Arponen E, Tenovuo O. Cholinergic dysfunction after traumatic brain injury preliminary findings from a PET study. Neurology (accepted).
Updated Nov-12
Contact details
Heikki Ukkonen
M.D., Ph.D., Docent
Department of Medicine,
Turku University Hospital
PO Box 52, 20521 Turku
e-mail:
[email protected]
phone: +358 2 3130011
mobile: +358 40 5343266
fax: +358 2 3132030
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Cardiology | 2005 | University of Turku
Specialist Degree in Nuclear Cardiology | 2002 | CBNC, USA
Specialist Degree in Internal Medicine | 1999 | University of Turku
PhD | 2001 | University of Turku
MD | 1991 | University of Turku
Chief Specialist | 2009 | Medicine/Cardiology, Turku University Hospital
Researcher | 2001 - 2003 | University of Ottawa Heart Institute
Adjunct Professor / Docent | 2008 | University of Turku
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research
experience
GCP training
Resources available for
clinical research
Internal Medicine: Cardiology
Echocardiogram
Medical Imaging: Radiology, Nuclear Medicine, PET,
Clinical trials on medicinal products
research Observational trials
Principal investigator
Clinical trials on medical devices
Other medical
Sub-investigator
Over 15 years
GCP-training organised by a previous sponsor
Two research nurses. Resources available include Cardiac ultrasound (TEE and TTE),
catheterization laboratory, electrophysiology laboratory, outpatient clinic, cardiology ward
and CCU. Through collaboration with Turku PET Centre we have access to PET/CT and MRI.
Representative publications
Ukkonen H, Saraste M, Akkila J, Knuuti J, Karanko M, Iida H, Lehikoinen P, Någren K, Lehtonen L, Voipio-Pulkki LM. Myocardial efficiency
during levosimendan infusion in congestive heart failure. Clin Pharmacol Ther 2000; 68:522-31.
Ukkonen H, Beanlands R, MD, Burwash I, de Kemp R, Nahmias C, Fallen E, Hill M, Tang A. The effect of cardiac resynchronization on
myocardial efficiency and regional oxidative metabolism. Circulation 2003; 107:28-31.
Stolen KQ, Kemppainen J, Ukkonen H, et al. Exercise Training Improves Biventricular Oxidative Metabolism and Left Ventricular Efficiency
in Patients with Dilated Cardiomyopathy. J Am Coll Cardiol 2003; 41:460-467.
Huikuri HV, et al. Effects of intracoronary injection of mononuclear bone marrow cells on left ventricular function, arrhythmia risk profile,
and restenosis after thrombolytic therapy of acute myocardial infarction. Eur Heart J 2008; 29:2723-32.
Kajander S, Joutsiniemi E, Saraste M, Pietilä M, Ukkonen H, et al. Cardiac positron emission tomography/computed tomography imaging
accurately detects anatomically and functionally significant coronary artery disease. Circulation 2010; 122:603-613.
Updated Nov-12
Contact details
Eija Vesti
Department of
Ophthalmology,
Turku University Hospital
PO Box 52
FI-20521 Turku
Finland
MD, PhD, Professor
e-mail: [email protected]
phone: +358 2 3131590
fax: +358 2 3139009
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist Degree in Ophthalmology | 1993 | University of Helsinki
PhD | 1994 | University of Helsinki
MD | 1986 | University of Helsinki
Chief Physician | 2009 - | Department of Ophthalmology, Turku University Hospital
Medical Specialist | 1993 - 2009 | Department of Ophthalmology,
Helsinki University Central Hospital
Specialising Physician | 1988 - 1993 | Department of Ophthalmology,
Helsinki University Central Hospital
Professor | 2009 - | Department of Ophthalmology, University of Turku
Adjunct Professor / Docent | 1999 - | Department of Ophthalmology, University of
Helsinki
Clinical research
Therapeutic areas
Previous clinical trials
Position in clinical trials
Total clinical research
experience
Ophthalmology: Glaucoma, Ophthalmic Surgery, Psychophysics
Other medical research
Sub-investigator
Over 15 years
Representative publications
Vesti E, Johnson CA, Chauhan BC. Comparison of different methods for detecting glaucomatous visual field progression. Invest
Ophthalmol Vis Sci. 2003; 44:3873-3879.
Vesti E, Johnson CA, Chauhan BC. Comparison of different methods for detecting glaucomatous visual field progression. Invest
Ophthalmol Vis Sci. 2003; 44:3873-3879.
Harju M, Saari J, Kurvinen L, Vesti E. Reversal of optic disc cupping in glaucoma. Br J Ophthalmol. 2008, 92:901-905.
Forsman E, Kivelä T, Vesti E. Lifetime visual disability in open-angle glaucoma and ocular hypertension. J Glaucoma. 2007; 16:313–319.
Suominen S, Harju M, Ihanamäki T, Vesti E. The effect of deep sclerectomy on intraocular pressure of normal-tension glaucoma patients:
1-year results. Acta Ophthalmol Scand. 2010; 88:27-32.
Updated Nov-12
Contact details
Heli Ylä-Outinen
MD, PhD
Department of Pulmonary
Diseases, Turku University
Hospital, Hämeentie 11,
20520 Turku
e-mail: [email protected]
phone: +35823130000
Curriculum Vitae
Degrees
Current and relevant
previous positions
Specialist in Pulmonary Diseases | 2009 | University of Turku
PhD | 2002 | University of Oulu
MD | 1996 | University of Oulu
Medical Specialist | 2009 - | Dept. of Pulmonary Diseases, Turku University Hospital
Clinical research
Therapeutic areas
Pulmonary Diseases: Asthma, COPD
Previous clinical trials
Clinical trials on medicinal products
Position in clinical trials
Total clinical research
experience
GCP training
Resources available for
clinical research
Medical Biochemistry
Principal investigator
0–5 years
GCP-training organised by a previous sponsor
A study nurse (Tiina Tammi)
Representative publications
Haahtela T, Tamminen K, Malmberg LP, Zetterström O, Karjalainen J, Ylä-Outinen H, et al. Formoterol as needed with or without
budesonide in patients with intermittent asthma and raised NO levels in exhaled air: A SOMA study. Eur Respir J. 2006; 28:748-55.
Annunen-Rasila J, Kärppä M, Finnilä S, Ylä-Outinen H, et al. Cytoskeletal structure in cells harboring two mutations: R133C in NOTCH3
and 5650G>A in mitochondrial DNA. Mitochondrion. 2007; 7:96-100.
Koivunen J, Karvonen SL, Ylä-Outinen H, Aaltonen V, Oikarinen A, Peltonen J. NF1 tumor suppressor in epidermal wound healing with
special focus on wound healing in patients with type 1 neurofibromatosis. Arch Dermatol Res. 2005; 296:547-54.
Korkiamäki T, Ylä-Outinen H, Leinonen P, Koivunen J, Peltonen J. The effect of extracellular calcium concentration on calcium-mediated
cell signaling in NF1 tumor suppressor-deficient keratinocytes. Arch Dermatol Res. 2005; 296:465-72.
Karvonen SL, Koivunen J, Nissinen M, Ylä-Outinen H, Björkstrand AS, Peltonen J. Neurofibromatosis type 1 tumour suppressor gene
expression is deficient in psoriatic skin in vivo and in vitro: a potential link to increased Ras activity. Br J Dermatol. 2004; 150:211-9.
Updated Nov-12