Sensing Opportunities for Diagnostics
in Healthcare and Wellbeing
20.11.2012 Micronova
Workshop summary and next steps
Sensing Opportunities for Diagnostics in Healthcare and Wellbeing
• Societal needs
• Grand
challenges
•
•
•
•
•
Value chain building - Bridging the innovation gap
Bring all different players together
Identify and select common topics for collaboration
Goal oriented approach => Actions and Next steps how to
continue to crate innovations for Healthcare and wellbeing
Start of the Health Factory ecosystem
Sensing Opportunities for Diagnostics in Healthcare and Wellbeing
Workshop Groups
1. Mobile diagnostics, rehabilitation and sport: Jouni Lounasmaa, COO, Traxmeet Oy
2. Ageing and memory disorders, independent living: Raimo Sepponen, Professor, Aalto
University
3. Low cost diagnostics for rural areas: Harri Siitari, Senior Principal Scientist, VTT
4. Personal healthcare (metabolic syndrome, diabetes): Pekka Ihalmo, Project Manager,
Culminatum
5. Neurotechnology, diagnostics and brain imagining: Risto Ilmoniemi, Academy Professor, Aalto
University
6. Clinical Diagnostics: Jouko Haapalahti, Programme Director, Salwe Ltd
7. Business Models: Pekka Mustonen, Managing Director, Duodecim Medical Publications Ltd
Group 1. Mobile diagnostics, rehabilitation and sport
Jouni Lounasmaa, COO, Traxmeet Oy
Participants: Mobile diagnostics, rehabilitation and sport
Veli-Matti
Korhonen
Ilkka
Lasse
Kati
Atte
Tapani
Tapani
Heikki
Jarkko
Panu
Markku
Paula
Eero
Anna
Tuija
Timo
Ville
Airaksinen
Timo
Tittonen
Leppäkorpi
Takaluoma
Lötjönen
Salmi
Koivukangas
Kuisma
Antila
Helistö
Jenu
Järivinen
Punkka
Rissanen
Teerinen
Varpula
Viikari
Aalto University
Aalto University
Aalto University
Beddit.com Oy
Culminatum Innovation Oy Ltd
Dublin City University
Helsinki University Hospital
Lewel Group Finland Oy
Murata Electronics Oy
VTT
VTT
VTT
VTT
VTT
VTT
VTT
VTT
VTT
Director
Professor
Professor
CEO
Project manager
Research Officer
MD
Specialist, Medical Devices
Director Advanced Development
Team leader
Dr
Key Account Manager
Senior scientist
Tech. Mgr
Team Leader
Senior Scientist
Technology Manager
Senior Scientist
Health2.0 market
MARKET DRIVERS
• Mobility (explosion of APPs)
• Device divergence (dedicated devices)
• Service convergence (cloud)
• Behavioural change – digital rituals
Sources: The future of connected health devices, IBM
Digital transformation in the Health and Wellness domain, Fjord, Oct 2012
Mobile diagnostics, rehabilitation and sport,
Group work summary 20.11.
Discussion topics
 Data safety of personal health data
 Data aggregation of personal health data e.g. Taltioni
 Behavioural change is a big challenge: there are different personal drivers and motivation for peopl
are young or old, healthy or sick, etc, depending on their life-phase and health conditions, and is al
much related to use context
Possible areas of interest
 Non-invasive analysis with e.g. (optical) MEMS sensors
 Long-term continuous data of personal health as a result of self-monitoring
 Hidden data about personal health e.g. non diagnosed diseases
 Wearable devices
Application areas
 home care services with analytics
 task related performance measurements e.g. during work in a mine or physically demanding task,
 health risk analysis with sensors
Group 2. Ageing and memory disorders, independent living
Raimo Sepponen, Professor, Aalto University
Participants: Ageing and memory disorders, independent living
Harri
Henna
Veli Pekka
Matti
Panu
Pekka
Klas
Lähdesmäki
Jalovaara
Tanninen
Huotari
Pekko
Pursula
Hjort
Aalto University
Academy Research Fellow
Culminatum Innovation Oy Ltd Project coordinator
Orion Oyj Orion Pharma
Senior Adviser
University of OULU
Postdoctoral Researcher
VTT
Senior Scientist
VTT
Senior Scientist
VTT
Visiting professor
2. Ageing and memory disorders, independent living: Raimo
Sepponen, Professor, Aalto University
2. Ageing and memory disorders, independent living: Raimo
Sepponen, Professor, Aalto University
Group 3. Low cost diagnostics for rural areas
Harri Siitari, Senior Principal Scientist, VTT
Participants: Low cost diagnostics for rural areas
Sauli
Holthöfer
Kari
Mikko
Coulton
Auli
Darshan
Martin
Henri
Belachew
Liisa
Heini
Harri
Törmälä
Harry
Jussila
Sairanen
Legge
Pere
Kumar
Albers
Arola
Feyssa
Hattara
Saloniemi
Siitari
BioNavis Oy
Dublin University
Master Disc Oy
PerkinElmer
Reckitt Benckiser
Tekes
University of Helsinki
VTT
VTT
VTT
VTT
VTT
VTT
CEO
Professor
Co-founder
Project manager
Manager
Chief Technology Adviser
Mr
Dr
Research Scientist
Reserach scientist
Research engineer
Team Leader
Senior Principal Scientist
Low cost diagnostics for rural
areas/India
- VTT Technologies for Health,
Innovation program
Harri Siitari, Ph.D, Docent,
Senior Chief Scientist
Auli Pere, Ph.D.
Chief Adviser
VTT
Tekes
Espoo, 20.11.2012
Affordable diagnostics in rural areas/India
 Central laboratories
 Sampling, sample materials (central labs+POCT), standardization, quality of samples
 POCT
 Technology development, specially sample related topics, also new markers needed
 Pricing of the system/sales of consumables
 Rapid prototyping services (collaborations), manufacturing expertise exists
 More content into the test strips
 Markets
 China (big investments in HC, copy-paste), India: many markets,
 Public/private sectors
 CFD etc can be a big investment, how to access the HC officials
 Very different in western countries as compared to rural areas
 Must give additional, real value (how many tests one can afford?)
 Eg still birth is a common problem, but reasons are different from western countries
 Service lab concept: timing/logistics
 StrepA test 250usd in US, in pharmacy 50usd (break down of costs)
 Various business models: BMGF, public HC, health economics (local), sustainable development
 Prioritization
 Needs very much still present in Africa
 Education (people have money) people+doctor, participate with local reliable Co (note regulations),
 Growing middle class, early adapters
 R&D together, INNOVATION BOOST
 To understand needs, must go there
Dream ticket,
•Anemia
needs in rural
•Diabetes
•Cardiovascular diseases
•Infectious diseases: malaria, TB, dengue…
•Sexually Transmitted Diseases
•Kidney, liver and mental problems
•Mother and child health
•Mobile and light weight
•Multiplex
•Easy to use
•Accurate
•Robust
•Ability to keep recordings and communicate
•50 -100 rs affordable for a single test
•Education, counseling, support
•Partnerships to overcome cultural and
language barriers
•In-depth local understanding
areas/India
From Rs. 50 lakh ultrasound machine
< Rs. 1 lakh
Non-expert operable
Dream ticket,
Affordable diagnostics in rural areas/India
Real value for patient
(eg re-testing) and health
Care as a whole
Good enough quality.
Sample & sampling
CRP spots
cTnI spots
AIC, 200 µm channels
10000
10000
5000
4500
1000
40001000
Adeno
3000 100
RSV
6404-Bio 0.5 mg/ml
2500
2000
Net signal
Signal
Net signal
3500
6404-Bio 0.1 mg/ml
Inf A
Kd
10
PIV3
100
9705-Bio 0.5 mg/ml
9705-Bio 0.1 mg/ml
Cutoff
10
Kd
1500
1000
1
1
500
0
0.1
0.1
933
1
467
233
10
117
58
100
29
[Hexon protein] (ng/ml)
1000
15
0
10
Education:
Right info in
Right place at
Right time
100
1000
10000
[cTnI] (pg/ml)
[CRP] (pg/ml)
Right cost structure
and quality, pricing
Instrument/consumables
Rapid results, easy-to-use
CO-DEVELOP with
Local partners
Group 4. Personal healthcare (metabolic syndrome, diabetes)
Pekka Ihalmo, Project Manager, Culminatum
Participants: Personal healthcare (metabolic syndrome, diabetes)
Miettinen
Joonas
Pekka
Riikka
Ulf
Päivi
Fagerström
Petri
Thea
Raimo
Paalasmaa
Ihalmo
Paasikivi
Meriheinä
Heimala
Richard
Saviranta
Sipiläinen-Malm
Aalto University
Beddit.com Oy
Culminatum
Culminatum
Murata Electronics Oy
VTT
VTT
VTT
VTT
Project coordinator
Chief Scientist
Project Manager
Program Director
Sr. MEMS Application Specialist
Senior scientist
Technology Manager
Senior scientist
Senior Scientist
18.12.2012
21
Personal healthcare devices
- Focus in diabetes and metabolic syndrome
18.12.2012
Prevention, prevention and prevention
 Incidence of diabetes, particularly type 2 diabetes, is growing rapidly
 Achieving tight glycaemic control is an important factor
 Focus in prevention
 identify people at high risk for the disorder
 encourage them to lose weight
 be more physically active
 follow a healthy eating plan
22
18.12.2012
23
Future of personal healthcare devices?
 Healthcare will shift from the hospital and clinic to the home and communities
 Consumerization of medical devices
 Mobile phones, tablets and laptops as platform
 Real-time monitoring of everyday life
 Sensors, chips, optics
 Personalized genomics as a game changer
 DNA sequencer plugged into a computer through a USB port
18.12.2012
24
Workshop output: Personal healthcare
 Non-invasive chips/sensors for personal healthcare
1. Need: Solutions exist, but they do not communicate, integration is needed (eg. HR,
GPS, weight, sweating, sleeping)
 Next step: Beddit and Murata
1. Need: New measurables and detection systems for non-invasive detection, eg. glucose,
cholesterol, lactic acid, acetone
 Next step: VTT / Electronics / Philippe Monnoyer
2. Need: Swalloable, disposable sensors (i-pills) to detect gastro-intestinal track
 Next step: VTT / Electronics / Philippe Monnoyer
3. Need: machine vision/nose of human being: eg. Detection of epileptic seizures, stress,
nervousness, hypoglycaemia
 Next step: VTT Tampere (Jyrki Lötjönen)
Group 5. Neurotechnology, diagnostics and brain imagining
Risto Ilmoniemi, Academy Professor, Aalto University
Participants: Neurotechnology, diagnostics and brain imagining
Risto
Ilmoniemi
Anna-Maria
Antti
Phong
Indrek
Tarmo
Kattelus
Janne
Antti
Bique
Ahonen
Vo
Tammeaid
Lipping
Hannu
Sallinen
Tullila
Aalto University
Brain Research Unit/ Aalto University School of
Science
Elekta Oy
Finmedex Ltd.
Greater Helsinki Promotion
TTY
VTT / MemsFab
VTT
VTT
Academy Professor
M.Sc., PhD Student
Vice President
Managing Director
Senior Business Advisor
Professor
CEO
Senior Scientist
Research Scientist
Brain imaging developed in Helsinki
MRI
MEG
EEG
Navigated TMS
NIRS
Ultra-Low-Field MRI
&MEG
Risto Ilmoniemi
Sensing Opportunities for Diagnostics in Healthcare and Wellbeing
Micronova, Espoo, Nov 20, 2012
The whole-head MEG dewar at BECS
• 2011: 72 SQUIDs, later 306 SQUIDs
• Simultaneous MEG and MRI
FP7 project MEGMRI, 2008-2012
Neurotechnology panel, results
 Finland is a hub for neurotechnology, has good future potential, and is excellent
for clinical trials
 Future trends: combined measurement and treatment devices, non-pharma
treatment (neurostimulation, mobile devices, games)
 Interesting and fruitful collaboration areas: imaging when implants in the
brain, MEG, MEG-MRI, TMS, detection of hypoxia with NIRS, human
performance enhancement, consumer devices, clinic in the office/home/phone,
bionic control systems, post-traumatic applications, neurogames (without
sensors, with mobile device’s sensors or with external sensors), data handling
and storage (secure cloud storage), nutritional neurotech
 Next steps
 Swiss-Finnish NeuroTech meeting on implants (HTA; J. Tuovinen)
 Finnish NeuroTech meetings (FiHTA & Greater Helsinki Promotion)
 Coordination by BECS/Aalto Univ. (Risto Ilmoniemi)
Sensing Opportunities for Diagnostics in Healthcare and Wellbeing, Micronova, Espoo, Nov 20, 2012
Group 6. Clinical Diagnostics
Jouko Haapalahti, Programme Director, Salwe Ltd
Participants: Clinical Diagnostics
Mikko
Marianna
Johana
Gerald
Albert
Craig
Pekka
Juha
Pasi
Eeva-Liisa
Bin
Itävaara
Jani
Marika
Maari
Helena
Syrjäsuo
Khanamiryan
Kuncova-Kallio
Urban
Manninen
Richmond
Kostiainen
Laiho
Kallio
Lakomaa
Guo
Merja
Mäntyjärvi
Nummela
Mäkinen
Henno
Aalto ELEC
Aalto University- School of Science
BioNavis Oy
IMTEK-Sensors
MIKES
Mittatekniikan keskus
Murata Electronics Oy
Photonics Finland
Tampere University of Technology
Vaisala Oyj
VTT
VTT
VTT
VTT
VTT Technical Research Centre of Finland
VTT TK4019
Technology Manager
Dr.
Director of Business Development
Professor
Researcher
Researcher
Business Development Manager
Koordinaattori
Professor
Dr.
Research Scientist
Principal Scientist
Principal Scientist
Research Scientist
Research scientist
Research trainee
32
18.12.2012
Clinical Diagnostics Group work #6 (17) Results Presentation
 Short conclusions
 We have opportunities to combine resources in developing new
targeted point-of-use type test systems , “ small is nice”
 Most interesting topics
 Transfer of testing from centralized to decentralized testing
 Systems miniatyrization , connectivity, ITC, non-invasiveness
 Infection testing & emergency testing, traveller`s safety
 Optical breath analyses, multiplexing, companion diagnostics
 Next steps
 Possible research areas
 Targeted point-of-use technology program
 Continuation meetings
 Solutions for infection detection , end-user aspects, regulatory
 Express of interest in further activities
 VTT, BioNavis, Mikes, Aalto Univ, Murata, TUT, SalWe, Photonics
Finland
 Leader for next steps to be taken
 VTT & Photonics Finland Juha Laiho
Strategic Centre for Health and Well-being (SHOK)
Research Program of Intelligent Monitoring of Health and Well-being (IMO)
Group 7. Business Models
Pekka Mustonen, Managing Director, Duodecim Medical Publications Ltd
Juhani Luotola, Orion Diagnostica Oy
Participants: Business Models
Jan
Pekka
Niina
Juhani
Sakari
Ossi
Jari
Sirpa
Julia
Anu
Philippe
Tarja
Jussi
Tuomas
Ekström
Aidertech Oy
Mustonen
Duodecim
Kuusanniemi-Abbotts Greater Helsinki Promotion
Luotola
Orion Corporation Orion Diagnostica
Kettunen
Planmeca Oy
Tiihonen
Remote Analysis Ltd.
Viik
Tampere University of Technology
Jylhä
VTT
Kantorovitch
VTT
Kaukovirta-Norja
VTT
Monnoyer
VTT
Nevanen
VTT
Tuovinen
VTT
Toivonen
VTT Expert Services Oy
Managing Director
CEO
Senior Business Advisor
Senior Technology Manager
Design Manager, Software
Founder
Professor
research scientist
Senior Researcher
Vice President
Technology Manager
Principal Scientist, Team Leader
VP
Lead Auditor, Medical Devices
18.12.2012
35
Business Models
Common questions for most cases:
•Do you have enough funding to prove your case ?
•Do you have the channel and resources to produce ?
•Who is certainly ready to pay ?
Strategic Center for Excellence in the Field of Health and Well-being (T&H SHOK)
Research Program of Intelligent Monitoring of Health and Well-being (IMO)
35
Strategic Centre for
Health and Well-being
Intelligent Monitoring of Health and
Well-being (IMO) Programme
Strategic Centre for Health and Well-being (SHOK)
18.12.2012
37
Business Models
SalWe as forum for developing new Business Models
for Diagnostics in Healthcare and Wellbeing ?
New SalWe programme starting 2014 under
preparation…
More information:
Saara Hassinen
[email protected]
p. +358 40 5311 661
Strategic Center for Excellence in the Field of Health and Well-being (T&H SHOK)
Research Program of Intelligent Monitoring of Health and Well-being (IMO)
Juhani Luotola
[email protected]
p. +358 50 966 2983
37
Seminar participants 20.11.2012
Fname
Mikko
Lname
Syrjäsuo
organisation
Fname
Lname
organisation
Gerald
Urban
IMTEK-Sensors
Aalto ELEC
18.12.2012
38
Fname
Lname
organisation
Martin
Albers
VTT
Jarkko
Antila
VTT
Henri
Arola
VTT
Belachew
Feyssa
VTT
Veli-Matti
Airaksinen
Aalto University
Risto
Ilmoniemi
Aalto University
Paavo
Kinnunen
Aalto University
Ali
Toivola
KeepLoop
Bin
Guo
VTT
Heidi-Maria
Lehtonen
Aalto University
Tapani
Koivukangas
Lewel Group Finland Oy
Kattelus
Hannu
VTT / MemsFab
Liisa
Hattara
VTT
Päivi
Heimala
VTT
Panu
Helistö
VTT
Helena
Henno
VTT
Klas
Hjort
VTT
Harri
Lähdesmäki
Aalto University
Miettinen
Raimo
Aalto University
Raimo
Sepponen
Aalto University
Korhonen
Timo
Aalto University
Ilkka
Tittonen
Aalto University
Jaakko
Raukola
KeepLoop
Kari
Jussila
Master Disc Oy
Tommi
Pisto
Medisapiens
Kristian
Ranta
Mendor
Albert
Manninen
MIKES
Markku
Jenu
VTT
Craig
Richmond
Mittatekniikan keskus
Buchert
Johanna
VTT
Sirpa
Jylhä
VTT
Paula
Järivinen
VTT
Julia
Kantorovitch
VTT
Anu
Kaukovirta-Norja
VTT
Jyrki
Lötjönen
VTT
Marianna
Khanamiryan
Aalto University- School of Science
Jan
Ekström
Aidertech Oy
Pekka
Kostiainen
Murata Electronics Oy
Klaus-Peter
Finke-Härkönen
Ajat Oy
Heikki
Kuisma
Murata Electronics Oy
Lasse
Leppäkorpi
Beddit.com Oy
Joonas
Paalasmaa
Beddit.com Oy
Johana
Kuncova-Kallio
BioNavis Oy
Sauli
Törmälä
BioNavis Oy
Anna-Maria
Bique
Brain Research Unit/ Aalto University School of Science
Francois
Berger
CEA
Ulf
Meriheinä
Murata Electronics Oy
Gustaf
Järnefelt
Nexstim
Arto
Maaninen
VTT
Juhani
Luotola
Orion Corporation Orion Diagnostica
Itävaara
Merja
VTT
Philippe
Monnoyer
VTT
Maari
Mäkinen
VTT
Veli Pekka Tanninen
Orion Oyj Orion Pharma
Annette
Onodera
Oy Ajat Ltd
Jani
Mäntyjärvi
VTT
Sairanen
PerkinElmer
Tarja
Nevanen
VTT
Marika
Nummela
VTT
Mari
Karsikas
Centre for Health and Technology
Mikko
Pekka
Ihalmo
Culminatum
Juha
Laiho
Photonics Finland
Juha
Palve
VTT
Riikka
Paasikivi
Culminatum
Sakari
Kettunen
Planmeca Oy
Panu
Pekko
VTT
Henna
Jalovaara
Culminatum Innovation Oy Ltd
Eero
Punkka
VTT
Pekka
Pursula
VTT
Kati
Takaluoma
Culminatum Innovation Oy Ltd
Atte
Lötjönen
Dublin City University
Holthöfer
Harry
Dublin University
Pekka
Mustonen
Duodecim
Antti
Ahonen
Elekta Oy
Coulton
Legge
Reckitt Benckiser
Ossi
Tiihonen
Remote Analysis Ltd.
Fagerström
Richard
VTT
Salwe
Anna
Rissanen
VTT
Janne
Sallinen
VTT
Saara
Hassinen
Jouko
Haapalahti
SalWe Ltd
Heini
Saloniemi
VTT
Pasi
Kallio
Tampere University of Technology
Sampo
Sammalisto
VTT
Petri
Saviranta
VTT
Harri
Siitari
VTT
Terhi
Kajaste
FiHTA ry
Jari
Viik
Tampere University of Technology
Johan
Lundin
FIMM
Auli
Pere
Tekes
Thea
Sipiläinen-Malm
VTT
Phong
Vo
Finmedex Ltd.
Jouni
Lounasmaa
Traxmeet
Kristiina
Takkinen
VTT
Joni
Kettunen
Firstbeat
Tuija
Teerinen
VTT
Risto
Rossi
GE Healthcare
Niina
Kuusanniemi-Abbotts
Greater Helsinki Promotion
Indrek
Tammeaid
Greater Helsinki Promotion
Tapani
Salmi
Helsinki University Hospital
Kristiina
Aittomäki
HUS
Tarmo
Lipping
TTY
Andrey
Timofeev
VTT
Darshan
Kumar
University of Helsinki
Tuomas
Toivonen
VTT
Antti
Tullila
VTT
Jussi
Tuovinen
VTT
Tomi
Rantamäki
University of Helsinki
Matti
Huotari
University of OULU
Timo
Varpula
VTT
Vaisala Oyj
Ville
Viikari
VTT
Eeva-Liisa Lakomaa