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Consensus conference
on salivary gland tumors
Adenoid-cystic carcinoma and high-grade neoplasms
A common commitment towards the future
October 23rd-24th 2014, School of Medicine, University of Brescia (Italy)
Consensus conference on salivary gland tumors
Adenoid-cystic carcinoma and high-grade neoplasms
Dear Colleagues,
The challenging management of salivary gland malignancies asks for a multidisciplinary
approach. In the last few years the knowledge in the field of basic science has grown
rapidly, and is probably becoming the driver for therapeutic choices in the future.
In keeping with this concept, the present conference wants to gather experts in the
fields of Pathology, Imaging, Surgery (ENT and Maxillo-Facial Surgeons), Radiation and
Medical Oncology to prepare for the future. Together we will delineate by consensus
the management of “problematic” salivary gland tumors for the next years.
This will be a 2-day consensus conference, with the first day dedicated to adenoid-cystic
carcinoma, and the second day focused on high-grade salivary gland malignancies.
Three topics for discussion (diagnosis, therapeutic approach to the primary lesion,
treatment of recurrent/metastatic disease) will characterize each day of the meeting.
Each session will consist of two parts: in the first, the “state of the art” will be defined
by experts, whereas in the second part the panelists and audience will try to reach a
consensus.
For each topic (diagnosis, treatment of primary tumor and metastatic disease), a
chairman and experts will be identified. They will be in charged of writing a document
that will be submitted to the panelists for comments, at least 6 months before the
date of the meeting. The final document will be discussed during the meeting between
experts and the audience to reach a consensus.
Congress Directors
Adel El-Naggar, Department of Pathology, M.D. Anderson Cancer Center, Houston, USA
Ehab Hanna, Department of Head and Neck Surgery, M.D. Anderson Cancer Center,
Houston, USA
Lisa Licitra, Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale
dei Tumori, Milan, Italy
Roberto Maroldi, Department of Radiology, University of Brescia, Italy
Piero Nicolai, Department of Otorhinolaryngology, University of Brescia, Italy
Scientific Secretariat
Laura Locati, Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale
dei Tumori, Milan, Italy
Davide Lombardi, Department of Otorhinolaryngology, University of Brescia, Italy
Ester Orlandi, Department of Radiation Oncology, Fondazione IRCCS Istituto Nazionale
dei Tumori, Milan, Italy
William Vermi, Department of Pathology, University of Brescia, Italy
Faculty
International Faculty
Ian Casselman, Department of Radiology, A.Z. St.-Jan Hospital, Bruges, Belgium
Jurgen Debüs, Department of Radiation Oncology, University of Heidelberg, Germany
Isabel Fonseca, Department of Head Neck Pathology, University of Lisbon, Portugal
David G. Pfister, Head and Neck Oncology Service, Memorial Sloan-Kettering Cancer
Center, New York, USA
Goran Stenman, Department of Pathology, Sahlgrenska Cancer Center, University of
Göteborg, Sweden
Carla M. van Herpen, Department of Medical Oncology, Radboud University Nijmegen
Medical Centre, Nijmegen, The Netherlands
Vicent Vander Poorten, Department of Head Neck Surgery, University of Leuwen, Belgium
Philippe Vielh, Department of Pathology, Institut Gustave Roussy, Paris, France
Randal Weber, Department of Head Neck Surgery, Houston, USA
Faculty
Italian Faculty
Mario Airoldi, Department of Medical Oncology, University of Turin
Antonino R. Antonelli, Department of Otorhinolaryngology, University of Brescia
Alfredo Berruti, Department of Medical Oncology, University of Brescia
Francesco Bertagna, Department of Nuclear Medicine, University of Brescia
Mario Bussi, Department of Otorhinolaryngology, University “S.Raffaele”, Milan
Flavio Crippa, Nuclear Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
Fabio Facchetti, Department of Pathology, University of Brescia
Carlo Fallai, Department of Radiation Oncology, Fondazione IRCCS Istituto Nazionale
dei Tumori, Milan
Davide Farina, Department of Radiology, University of Brescia
Piero Fossati, Department of Radiation Oncology, National Center for Adrotherapy
“CNAO”, Milan
Raffaele Giubbini, Department of Nuclear Medicine, University of Brescia
Gioacchino Giugliano, Department of Head and Neck Surgery, Istituto Europeo di
Oncologia, Milan
Marco Guzzo, Head and Neck Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
Stefano Magrini, Department of Radiation Oncology, University of Brescia
Ugo Pastorino, Thoracic Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
Cesare Piazza, Department of Otorhinolaryngology, University of Brescia
Paolo Potepan, Department of Head and Neck Radiology, Fondazione IRCCS Istituto
Nazionale dei Tumori, Milan
Giuseppe Sanguineti, Department of Radiation Oncology, National Cancer Institute
“Regina Elena”, Rome
Enrico Sesenna, Department of Maxillofacial Surgery, University of Parma
Giuseppe Spriano, Department of Head and Neck Surgery, National Cancer Institute
“Regina Elena”, Rome
Barbara Valeri, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei
Tumori, Milan
Program
08.00-08.10 Introduction: P. Nicolai
08.10-08.25 Honorary lecture: The history of adenoid-cystic carcinoma
A. R. Antonelli
Day 1, October 23rd 2014:
Adenoid-cystic carcinoma (ACC)
08.25-08.45 Lecture: Overview on molecular features of ACC and their impact on treatment. (A. El-Naggar) (20’)
08.45-09.45 1st Session: DIAGNOSIS
Chairman: A. El-Naggar
Panelists: I. Casselman, F. Crippa, F. Facchetti, B. Valeri
- Histopathologic definition, histologic subtypes and aggressive variants (G. Stenman) (15’) - FNAB and histology: the most frequent missclassifications (I. Fonseca) (10’)
- Overview on perineural spread: cellular and molecular mechanisms (W. Vermi) (10’)
- The role and limits of imaging (CT, MRI, and PET) in treatment planning (R. Maroldi-
R. Giubbini) (20’)
09.45-10.45 Consensus on:
- Histopathologic diagnostic criteria
- Diagnostic imaging
10.45-11.00 Coffee-break
Day 1, October 23rd 2014
11.00-12.30 2nd Session:TREATMENT OF THE PRIMARY LESION
Chairman: V. Vander Poorten
Panelists: P. Fossati, G. Giugliano, S. Magrini, L. Licitra, D. Lombardi
- Indications, suggestions and problems in surgical treatment of minor salivary glands adenoid-cystic carcinoma (P. Nicolai) (15’)
- Indications, suggestions and problems in surgical treatment of major salivary glands adenoid-cystic carcinoma (E. Hanna) (15’)
- Reconstructive issues and facial reanimation (C. Piazza, E. Sesenna) (20’)
- Indications to RT in an adjuvant and exclusive setting (+/- CHT) (E. Orlandi) (20’)
- Carbon-ion therapy (J. Debüs) (20’)
12.30-13.45 Consensus on:
- Treatment of the primary lesion
- Reconstruction and facial reinnervation
- Adjuvant and curative RT +/- CHT
13.45-14.45 Lunch
14.45-16.00 3rd Session: FOLLOW-UP AND RECURRENT/METASTATIC DISEASE
Chairman: R. Weber
Panelists: E. Hanna, E. Orlandi, M. Airoldi, D. Farina, F. Bertagna
- The role of imaging (CT, MRI and PET) in the post-treatment surveillance (I. Casselman) (15’)
- The role of surgery in the treatment of local relapse (V. Vander Poorten) (15’)
- The role of reirradiation in the treatment of local relapse (C. Fallai) (15’)
- The role of surgery in the treatment of lung metastasis (U. Pastorino) (10’)
- Therapy for locally advanced, recurrent and metastatic disease (D. G. Pfister) (20’)
16.00-18.00 Consensus on:
- Follow-up strategy
- Indications for surgery and/or reirradiation for recurrent primary lesions
- Indications for surgery for lung metastases
- Medical treatment for metastatic disease
Day 2, October 24th 2014:
High-grade salivary gland tumors (High-grade MEC, Salivary duct
carcinoma, Carcinoma ex-pleomorphic adenoma, Adenocarcinoma)
08.00-08.20 Lecture Overview on molecular features of high-grade salivary gland tumors and their impact on treatment (A. El-Naggar) (20’)
08.20-09.30 1st Session: DIAGNOSIS
Chairman: F. Facchetti
Panelists: I. Casselman, R. Giubbini, A. El-Naggar, B. Valeri
- Chromosomal rearrangements and fusion oncogenes (G. Stenman) (20’’)
- The role of FNA in diagnosis and molecular testing of salivary gland cancers (P. Vielh) (15’)
- Histopathologic definition and differential diagnosis (I. Fonseca) (15’)
- The role and limits imaging (CT, MRI and PET) in treatment planning (D. Farina - F. Crippa) (15’)
09.30-10.40 Consensus on:
- Histopathologic diagnostic criteria
- Diagnostic imaging
10.40-10.55 Coffee-break
10.55-11.50 2nd Session:TREATMENT OF THE PRIMARY LESION AND THE NECK
Chairman: M. Bussi
Panelists: M. Guzzo, J. Debüs, A. Berruti, L. Locati
- Indications, suggestions, and problems in surgical treatment of high-grade salivary gland tumors (V. Vander Poorten) (15’)
- Indications, suggestions, and problems in surgical treatment of the neck in high-grade salivary glands tumors (G. Spriano) (15’)
- Indications for RT in an adjuvant and exclusive setting (+/- CHT) (G. Sanguineti) (20’)
Day 2, October 24th 2014
11.50-13.10 Consensus on:
- Surgical indications for the treatment of primary lesions and the neck
- Indications for adjuvant treatment and exclusive RT (+/-ChT)
13.10-14.10 Lunch
14.10-15.10 3rd Session: FOLLOW-UP AND RECURRENT/METASTATIC DISEASE
Chairman: L. Licitra
Moderators:E. Hanna, C. Fallai, R. Maroldi/D. Farina, F. Bertagna
- The role of imaging in the post-treatment surveillance (P. Potepan - F. Crippa) (15’)
- The role of surgery in the treatment of loco-regional relapse (R. Weber) (15’)
- The role of reirradiation in the treatment of loco-regional relapse (S. Magrini) (15’)
- Systemic therapy for locally advanced, recurrent and metastatic disease (C. M. Van Herpen) (15’)
15.10-16.30 Consensus on:
- Follow-up strategy
- Indications to surgery and/or re-irradiation for recurrent primary lesions
- Systemic treatment for metastatic disease
16.30-17.00 Closing remarks
General informations
Language The official language will be English.
ECM/CME The course will ECM and CME accredited.
Hotel booking For information and booking please contact the Organizing Secretariat.
Course Venue School of Medicine - University of Brescia
Insurance
Via Valsabbina, 19 - 25121 Brescia - Italy
Organizers do not accept responsability for individual medical, travel or personal expenses.
Registrants are strongly advised to take out their own personal insurance policies.
Cancellation Policy
In the unusual circumstance that the course is cancelled, two weeks notice will be given and the
fee will be refunded in full. The Organizers are not responsible for any airfare, hotel or other costs
incurred.
Organizing Secretariat
Servizi C.E.C. Srl - Via G. Verdi, 18 - 24121 Bergamo - Italy
Phone +39.(0)35.249899 Fax. +39.(0)35.237852
e-mail: [email protected] www.servizicec.it
How to reach the University of Brescia-School of Medicine
By car Highway A4 Milano-Venezia.
• Exit Brescia Ovest; at the exit follow Tangenziale Ovest proceed along Tangenziale Nord. Follow
for Stadio or Ospedale, proceed along via Oberdan. Go through, turn left for Via Triumplina and
after 800 mt. turn right through Via Branze, on your left there’s the School of Engineering and on
the right hand there is School of Medicine.
• Exit Brescia Centro; at the exit take the Tangenziale Sud follow the road signs that take to
Tangenziale. Please follow the one with Val Trompia, Milano or Bergamo. Arrived in the Tangenziale,
proceed along till the road sign Tangenziale Ovest or Val Trompia. Now drive thorugh Tangenziale
Ovest and go ahead to Tangenziale Nord, follow the road signs Stadio or Ospedale. Keep driving
on via Oberdan till the end, then turn left on Via Triumplina and after 800 mt. turn right through
Via Branze, on your left there’s the School of Engineering and on the right hand there is School of
Medicine.
By TrainYou can reach the School of Medicine via bus, subway or taxi
By Taxi The taxi stand is just outside the train station.
By Bus • Line 1: direction Mompiano, bus stop via Schivardi.
• Line 15: direction Villaggio Montini, bus stop Viale Europa, corner via Branze.
By Tube Blue line, stop at Europa
Parking Closed to the School of Medicine there are:
Parcheggio Ospedale Nord and Parcheggio Ospedale Sud.
October 23rd-24th 2014, School of Medicine, University of Brescia (Italy)
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October 23rd-24th 2014, School of Medicine, University of Brescia (Italy)
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October 23rd-24th 2014, School of Medicine, University of Brescia (Italy)
Consensus conference on salivary gland tumors
Adenoid-cystic carcinoma and high-grade neoplasms
Organizing Secretariat
Servizi C.E.C. Srl
Via Verdi, 18 - 24121 Bergamo - Italy
Tel. +39.035.249899 Fax +39.035.237852 Mob. +39.339.6339391
[email protected] www.servizicec.it