Synthetic Biology and Advanced Manufacturing - A Chemical Industry Perspective

Synthetic Biology and Advanced Manufacturing
- A Chemical Industry Perspective
Thomas M. Connelly
Executive VP & Chief Innovation Officer
1
Success Factors for Biotech-Derived Chemicals
Biotechnol. J. 2012, 7, 176–185
2
Many Theoretical Routes to Renewable Chemicals
3
Biomaterials Competitive Landscape
Source: Morgan Stanley
4
Early Commercialization of Bioproducts
Biotechnol. J. 2012, 7, 176–185
5
Bio-PDO™ (1,3 Propanediol)
Genome
Economic
Production of PDO
Cell
Factory
E.coli has been
programmed to
increase Bio-PDO™
production 500-fold
Corn Grain
In Nature:
two microorganisms
convert glucose
Starch
to PDO stepwise
Glucose
Glycerol
Yeast
Biotech Application:
a single microorganism to
effect the conversion
Glucose
Programmed E. coli
PDO
Bacterium
OH
OH
……..
7