Synthetic Biology and Advanced Manufacturing - A Chemical Industry Perspective Thomas M. Connelly Executive VP & Chief Innovation Officer 1 Success Factors for Biotech-Derived Chemicals Biotechnol. J. 2012, 7, 176–185 2 Many Theoretical Routes to Renewable Chemicals 3 Biomaterials Competitive Landscape Source: Morgan Stanley 4 Early Commercialization of Bioproducts Biotechnol. J. 2012, 7, 176–185 5 Bio-PDO™ (1,3 Propanediol) Genome Economic Production of PDO Cell Factory E.coli has been programmed to increase Bio-PDO™ production 500-fold Corn Grain In Nature: two microorganisms convert glucose Starch to PDO stepwise Glucose Glycerol Yeast Biotech Application: a single microorganism to effect the conversion Glucose Programmed E. coli PDO Bacterium OH OH …….. 7
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