SAINT LUKE’S Research Annual Report 2013 Central Office of Research Administration Contents 2 A Message from Julie L. Quirin 3 Research Benefits Saint Luke’s Patients 4 Central Office of Research Administration (CORA) 6 Saint Luke’s Mid America Heart Institute 11 Saint Luke’s Cancer Institute 12 Saint Luke’s Marion Bloch Neuroscience Institute 14 Diagnostic and Interventional Radiology 15 Henry & Marion Bloch Liver Disease Management & Transplant Center 16Nursing 17Pharmacy 18Anesthesiology 19 Women & Children 19 Spiritual Wellness 20 Saint Luke’s Hospital Institutional Review Board 21 2013 Research Day 22 2013 Research Day Winners 25 2013 Scholarly Activities 30 2013 Publications 42 2013 Abstracts & Presentations 2013 Research Annual Repor t // Central Office of Research Administration 1 A Recognized Research Leader For more than 130 years, research and innovation have been fundamental to the mission of Saint Luke’s Hospital and Saint Luke’s Health System. In fact, many of our research activities, especially in cardiovascular disease and neurology, have earned national and international acclaim. But our commitment to research extends into many additional disciplines throughout our organization. Nearly 350 active investigators were involved in 434 active studies in 2013. The quality and quantity of this research demonstrates why many of the nation’s leading clinicians choose to be part of the Saint Luke’s team. This report summarizes their impressive work for 2013. One of the ways Saint Luke’s supports the work of our researchers is through the Central Office of Research Administration (CORA). CORA facilitates investigator-initiated and sponsored trials. CORA also provides assistance in the proper conduct of research and research compliance, helping to ensure the research conducted at Saint Luke’s Health System always meets the highest standards. CORA’s support is vital to the success of our research efforts. Julie L. Quirin Chief Executive Officer Saint Luke’s Hospital Saint Luke’s is dedicated to always providing the highest quality, most advanced care possible. As you will see on the following pages, our commitment to new technology and therapy through clinical and translational research ensures we always fulfill this commitment. Sincerely, 2 John Yeast, M.D. Vice President, Medical Education & Research Veronica Koontz CORA Research Services Coordinator Ellen McDowell CORA Program Director Mike Coffman CV Research, Director of Operations Lynn Parsons CORA Compliance Manager Julie Weiss SLCI Research Services/Compliance Manager Mindy Peters CORA Clinical Research Nurse II Dena McDonell CV Research, Grants and Contracts Manager Matthew Jones CORA Research Financial Auditor Marilyn Horn IRB Administrator 2013 Research Annual Repor t // Central Office of Research Administration Research Benefits Saint Luke’s Patients Saint Luke’s Health System is among the top research facilities in the Midwest Saint Luke’s researchers are conducting more than 430 research studies with nearly 350 active researchers. They have enrolled nearly 6,000 patients in research trials. And they draw sponsorship from the National Institutes of Health, the American Heart Association, the National Cancer Institute, pharmaceutical and medical device companies, as well as Saint Luke’s Foundation. All of this makes Saint Luke’s Health System among the top health care research facilities in the Midwest in terms of the number and scope of studies—and a great place to conduct clinical and translational research. Research support Saint Luke’s supports its medical researchers: •S aint Luke’s Foundation supports 13 clinical scholars. • The Central Office of Research Administration (CORA) exists to nurture and facilitate investigator-initiated and sponsored trials. •C ORA provides comprehensive oversight for the Saint Luke’s research enterprise and is the foundation for growth of research within Saint Luke’s Health System. •C ORA is responsible for centralizing, standardizing, and organizing research practices common to all product line research programs throughout the health system, guaranteeing clinical and financial compliance. Research sets us apart Saint Luke’s research: • Provides patients access to leading-edge, innovative treatment options • Showcases national and international successes of Saint Luke’s innovations in health care, health care policy, and outcomes • Develops strategic collaborations among health care providers/hospital with national, international, and community research partners • Attracts the highest quality providers and supports their academic interests • Translates best evidence into best practices of care • Differentiates Saint Luke’s organizations from other regional health care facilities and contributes to profitability of the health system 2013 Research Across Saint Luke’s Health System $7,557,433 external funding from federal and private sponsors 338 active investigators 434 active studies 5,995 patients enrolled in 2013 206 publications 332 abstracts/presentations 65 studies for which CORA mentored investigators 2013 Research Annual Repor t // Central Office of Research Administration 3 Central Office of Research Administration (CORA) Strengthening the Saint Luke’s Research Enterprise The Central Office of Research Administration (CORA) provides comprehensive oversight for the Saint Luke’s research enterprise and is the foundation for growth of research throughout Saint Luke’s Health System. Through the centralization of research administrative services, CORA focuses on three core responsibilities: Services • Centralization, standardization, and organization of research practices common to all product line research programs throughout Saint Luke’s Health System • Research administration strategic plan development and implementation • Centralized voice of research administration for dissemination of information, fielding research process questions, and relationship building with internal and external entities Compliance assurance • Authority to ensure clinical and financial compliance with all federal and state regulations governing the conduct and financial management of clinical research John Yeast, M.D. Vice President, Medical Education and Research Saint Luke’s Hospital 4 • Compliance, which helps to assure safety for Saint Luke’s Health System organizations and patients • Performing financial and clinical audits •G overnment grants management and assistance with industry-sponsored grants negotiation and management Quality practices and growth of the research enterprise • Incubation and mentorship of new researchers plus new product line research programs • Research contract and budget negotiation to ensure uniformity, and subsequent central archiving of documents • Relationship building with industry leaders enabling enhanced recruitment of studies • Training of principal investigators and research staff Growth initiatives for the research enterprise at Saint Luke’s Hospital, and throughout Saint Luke’s Health System, are guided by the CORA team, which collectively possesses nearly five decades of experience. Saint Luke’s research teams are well positioned to succeed thanks to resources provided by the Central Office of Research Administration. The research enterprise at Saint Luke’s is well developed and growing. Research strategies within therapeutic product lines continue to be strengthened each year. CORA provides the foundation of support for these research programs as well as for seasoned investigators and established research efforts.We are fortunate to have the CORA staff with their expertise in research and regulatory compliance to guide us and to add to our success as an organization. 2013 Research Annual Repor t // Central Office of Research Administration Saint Luke’s Research: Enhancing Patient Care Research at Saint Luke’s Health System spans multiple disciplines but always focuses on providing new options for patients at Saint Luke’s and around the world. 2013 Research Annual Repor t // Central Office of Research Administration 5 Saint Luke’s Mid America Heart Institute Pioneering work continues in developing treatments to improve the survivability and quality-of-life of patients suffering from heart disease Cardiovascular research continues to be a major focus at Saint Luke’s Hospital. The program currently encompasses research programs in each of the major clinical areas including interventional cardiology, cardiac surgery, heart failure and cardiac transplantation, cardiac electrophysiology, echocardiography, nuclear cardiology, and preventive cardiology/lipid and diabetes management. David Cohen, M.D., M.Sc. Director of Cardiovascular Research Saint Luke’s Mid America Heart Institute The University of Missouri Endowed Chair in Cardiovascular Clinical Research at the Mid America Heart Institute These programs, which enroll hundreds of patients annually in a broad range of randomized trials and registry-based research studies, are essential to the mission of Saint Luke’s Mid America Heart Institute (MAHI). Research allows MAHI to remain on the leading edge of cardiovascular care. In addition to these clinical research programs, many MAHI cardiologists Saint Luke’s Mid America participate in Heart Institute research: research through the Ben D. McCallister 179 active studies Clinical Scholars 1,277 patients enrolled Program, which provides funding 150 publications and support for investigator-initiated 226 abstracts/presentations studies. The cardiovascular research program encompasses centers of excellence and core laboratories in cardiovascular outcomes research, health economics and technology assessment, intravascular imaging, and noninvasive imaging. These centers of excellence currently serve as core laboratories for a wide range of studies that often involve collaboration with leading cardiovascular centers and researchers from around the world. 6 2013 Highlights An Unprecedented ‘Triple Play’ Three highly prestigious journals in one week The three most important general medical journals in the world are the New England Journal of Medicine, the Journal of the American Medical Association (JAMA), and The Lancet. Although most researchers would be thrilled to publish a paper in one of these major journals during their careers, in 2013, the cardiovascular research program at MAHI was fortunate to have three papers published during a single week – one in each of these highly prestigious journals. Paul Chan, M.D.,* directed a study investigating long-term outcomes among patients who survive an episode of in-hospital cardiac arrest that was published in the New England Journal of Medicine. Adnan Chhatriwalla, M.D., and Steven Marso, M.D., conducted a study of more than 1 million patients undergoing percutaneous coronary revascularization that explored the contribution of post-procedural bleeding to subsequent in-hospital mortality that was published in JAMA. And concurrently, Randall Thompson, M.D., directed an important study exploring the origins of atherosclerosis in early humans based on findings from CT scans of mummies collected from around the globe, the results of which were published in The Lancet. The simultaneous publication of these three studies, each led by MAHI investigators is testimony to the breadth, depth, and worldwide recognition of the quality of the science being led by our talented investigators. MAHI Receives Highly Competitive PCORI Grants MAHI investigators were honored to receive a number of grants to support a broad range of new research efforts in 2013. Two of these grants were awarded to the Cardiovascular Outcomes Research Group and its investigators by the Patient-Centered Outcomes Research Institute (PCORI)—a federally funded program designed to help people make informed health care decisions, and to improve health care delivery and outcomes, by producing and promoting high integrity, evidencebased information that comes from research guided 2013 Research Annual Repor t // Central Office of Research Administration * Refer to page 59 by patients, caregivers, and the broader health care community. One PCORI grant, PORTRAIT, is being codirected by Kim Smolderen, Ph.D., and John Spertus, M.D., and will investigate trajectories of clinical and patient-reported outcomes among individuals with peripheral artery disease. The second PCORI-funded project is being co-directed by Dr. Chhatriwalla and Dr. Spertus and will investigate the ability of a nurse-led educational intervention to allow patients to make more informed and patient-centered decisions around percutaneous coronary revascularization. Each of these grants was for approximately $1.5 million and will support a range of interconnected projects over a three-year period. In addition to the PCORI grants, Aaron Grantham, M.D., was awarded a $3.5 million grant by Boston Scientific to develop and lead a multicenter registry of patients undergoing percutaneous coronary intervention of chronically occluded vessels. This study, known as OPEN-CTO, will involve many other investigators at MAHI and will seek to improve our understanding of the short- and longterm clinical, quality of life, and economic outcomes of some of the newest technical advances in the performance of this highly specialized procedure. Selected MAHI Research Programs Cardiovascular and Thoracic Surgical Research Under the direction of Keith Allen, M.D., and colleagues, the Department of Cardiovascular and Thoracic Surgery continues to maintain an active portfolio of research with participation in nine FDA clinical trials during 2013. Dr. Allen led a number of research studies in preventing wound complications and enhancing sternotomy healing following cardiac surgery. One study involving more than 7,000 Keith Allen, M.D. cardiac surgical patients published in JAMA evaluated the effect of an investigational vaccine for preventing Staphylococcus aureus infections in patients undergoing elective cardiac surgery. Within this theme, Dr. Allen is serving as national principal investigator for a multicenter trial evaluating the safety and efficacy of rigid sternal fixation versus wire cerclage during sternotomy closure. Research involving the surgical treatment of heart failure with cardiac transplantation or mechanical circulatory support continues to grow under the leadership of Michael Borkon, M.D., chairman of the Department of Cardiovascular and Thoracic Surgery and director of cardiac transplantation, and Sanjeev Aggarwal, M.D., director of mechanical and circulatory support. Dr. Aggarwal was leading enroller in the United States in Sunshine Heart’s C-Pulse trial, which successfully evaluated a novel extravascular counter pulsation device placed minimally invasively around the ascending aorta to treat patients with class III/ IV heart failure. Further studies of this device are planned for the coming years and, if successful, should pave the way for this novel treatment to expand treatment options for patients with advanced heart failure who do not require full circulatory support. Interventional Cardiology In addition to participating in multicenter clinical trials, interventional cardiologists at MAHI continue to lead a number of investigator-initiated research studies. David Safley, M.D., has been active in studying the evolving technique of transradial percutaneous coronary intervention (PCI). During the past year, along with colleagues from MAHI and several other programs, he led a study to examine the costs of transradial PCI as compared with transfemoral procedures, the results of which were published in the American Heart Journal. Another area of research interest for Dr. Safley is quality of life in patients with peripheral arterial disease. Along with colleagues from the MAHI Health Economics and Technology Assessment Group, he led a study to evaluate health outcomes of more than 200 patients undergoing superficial femoral artery (SFA) stenting as part of the industry-sponsored STROLL trial. These results, which were recently presented as a late-breaking clinical trial at the Vascular Interventional Advances (VIVA) meeting, were the first to demonstrate that the early benefits of SFA stenting are largely maintained over at least three years of follow-up. Dmitri Baklanov, M.D., is a MAHI interventional cardiologist and clinical scholar who is one of the leading experts in the technique of transradial catheterization and PCI. In addition to leading a number of courses on this technique, Dr. Baklanov continues to publish extensively on clinical and economic outcomes of transradial PCI. In a landmark study published in the Journal of the American College of Cardiology (JACC), Dr. Baklanov and colleagues found that although transradial PCI is utilized in only a minority of patients undergoing primary PCI for STEMI, its use is associated with substantial reductions in both bleeding as well as mortality. In addition, using data from the National Cardiovascular Data Registry (NCDR), he found that the combination of transradial PCI and bivalirudin anticoagulation result in the lowest bleeding 2013 Research Annual Repor t // Central Office of Research Administration 7 outcomes across the full spectrum of patient risk. The results of this study were published in Circulation: Cardiovascular Interventions. Adnan Chhatriwalla, M.D., is another MAHI interventional cardiologist with a growing research portfolio, focused primarily on the application of evidencebased practice in the cardiac catheterization laboratory. In 2013, Dr. Chhatriwalla and colleagues published two important studies evaluating bleeding complications following percutaneous coronary intervention (PCI). In a study published in the Adnan Chhatriwalla, M.D. Journal of the American Medical Association (JAMA), he found that 12.1 percent of in-hospital deaths following PCI in the United States can be attributed to bleeding complications, and that non-access site bleeding impacts mortality more substantially than access-site bleeding. In a second study published in the Journal of the American College of Cardiology (JACC), they reported that the use of individualized bleeding risk estimates for patients undergoing PCI at Saint Luke’s Mid America Heart Institute was associated with increased use of bivalirudin in high-risk patients and a dramatic reduction in the incidence of bleeding complications. Finally, as described on p. 6, Dr. Chhatriwalla and Dr. Spertus recently received a three-year research award from the Patient-Centered Outcomes Research Institute (PCORI) to create and test a decision aid to educate patients about drug-eluting and bare-metal 8 stents and support shared decision-making with respect to stent selection at the time of PCI. Cardiovascular Outcomes Research Under the joint direction of John Spertus, M.D., M.P.H., and Carole Decker, R.N., Ph.D., FAHA, CPHQ, the MAHI Outcomes Research program continues to rank as one of the leading programs in cardiovascular outcomes research in the world. In 2013, Dr. Spertus and his team published more than 65 peer-reviewed articles on the quality of care and outcomes of patients with cardiovascular disease. Beyond their ongoing efforts to promote the importance of 1) patient-reported outcomes as a means to better integrate patients’ symptoms, 2) function and quality of life as outcomes in clinical trials, 3) quality assessment and shared decision-making, their research has recently focused on the development of an infrastructure to support personalized medicine. A nine-center study* in the setting of angioplasty was able to support the execution of multivariable risk models from the American College of Cardiology into the flow of routine patient care. This study established that this personalized approach improved patients’ experiences with care, tailored treatment with bleeding avoidance strategies to those who most benefit, reduced bleeding complications and enabled more efficient care with reduced costs. In collaboration with investigators from Saint Luke’s Marion Bloch Neuroscience Institute and the University of California-Los Angeles, this methodology is currently being extended to the treatment of acute ischemic stroke, a historically undertreated condition. Dr. Spertus, the Daniel J. Lauer/ University of Missouri Endowed Chair in Metabolism and Vascular Research at 2013 Research Annual Repor t // Central Office of Research Administration * Refer to page 59 Saint Luke’s Hospital of Kansas City, continues to lead an NIH/NHLBI-funded training grant in outcomes research and has collaborated with numerous faculty and trainees throughout the country. The project is in collaboration with University of Missouri – Kansas City. He continues to serve as the deputy editor of Circulation: Quality of Care and Outcomes. In recognition of his long-standing commitment to the field, Dr. Spertus was awarded the American Heart Association’s Distinguished Achievement Award by the Quality of Care and Outcomes Research Council. This award, given only once every three years, recognizes excellence in scholarship, mentorship, and significant contributions to the field. Noted MAHI Investigators Health Economics and Technology Assessment (HETA) Under the joint direction of David Cohen, M.D., director of cardiovascular research, and Elizabeth Magnuson, Sc.D., the MAHI HETA group continues to provide leadership to a large number of multicenter studies designed to evaluate the cost-effectiveness of novel cardiovascular technologies. During the past year, the HETA group has focused on several clinical trials evaluating alternative approaches to revascularization of patients with complex multivessel coronary disease. One such study was the FREEDOM* trial, a NIH-sponsored clinical trial of PCI versus bypass surgery for patients with diabetes and multivessel coronary disease and demonstrated that bypass surgery led to improved longterm outcomes. The economic analysis led by the HETA group demonstrated that bypass surgery was also a highly cost-effective treatment for these patients. These findings, which were published in Circulation, serve to reinforce and strengthen current guidelines that recommend bypass surgery as first-line therapy for diabetic patients with multivessel coronary disease. The quality of life component of the FREEDOM trial was recently published in JAMA and demonstrated that bypass surgery also led to improved quality of life outcomes compared with PCI—particularly over the first several years of follow-up. In addition, the MAHI HETA group continues to maintain an active portfolio of more than a dozen health economic studies carried out alongside pivotal NIH and private industry-sponsored clinical trials relating to treatments for ischemic heart disease, atrial fibrillation, valve disease, acute stroke, and peripheral vascular disease. • Randall Thompson, M.D., conducted one of the more unusual ongoing research projects at MAHI involving the use of CT scanning to study heart and vascular disease in the remains of ancient humans. CT scans of mummies spanning more than 4,000 years from wide regions of the globe refute the thought that atherosclerosis is a disease caused by modern lifestyles. Dr. Thompson and his team recently published their findings in The Lancet. This project created intense worldwide media interest including thousands of newspapers, television and radio programs, as well as periodicals such as Popular Science and Science Magazine. This unique work may ultimately help find missing risk factors and causes for this most common of diseases. Over the next 12 months, the HETA group will be completing a number of long-running studies including studies investigating the cost-effectiveness of PCI versus bypass surgery for patients with three-vessel and left main disease (as part of the SYNTAX trial), renal artery stenting versus optimal medical therapy for patients with atherosclerotic renal artery stenosis (as part of the NIHsponsored CORAL* trial), and the novel anticoagulant edoxaban versus warfarin for patients with atrial fibrillation (as part of the ENGAGE-TIMI 48 trial). • Suzanne Arnold, M.D., M.H.A., led a number of studies looking at quality of life in patients with valvular heart disease, focusing specifically on patients with aortic stenosis considering transcatheter aortic valve replacement (TAVR) – a novel form of valve replacement. Along with Dr. Cohen, she has recently developed and validated a statistical model to identify patients who are at high risk for doing poorly with this new procedure. The information learned could help patients and their families make more * Refer to page 59 • • Paul Chan,* M.D., M.Sc., completed the most comprehensive and representative study of in- hospital cardiac arrest survivors to date. Results were published in the New England Journal of Medicine. The study found that the three-year survival rate of cardiac arrest survivors was similar to that of patients with heart failure, dispelling pessimistic attitudes on the life- expectancy of survivors of in-hospital cardiac arrest. For this and his other recent seminal studies in cardiac arrest care, Dr. Chan was named the 2013 American Heart Association Dickinson W. Richards Memorial Lecturer on Resuscitation Science. Sanjaya Gupta, M.D., is a cardiac electrophysiologist whose research program focuses on outcomes research in patients with heart rhythm disorders. One of his current research interests is the intersection of cardiac electrophysiology and sleep apnea, which has led to the development of a novel method of screening for sleep apnea in patients with implantable cardioverter defibrillators (ICD). Based on analysis of more than 300 ICD recordings, Dr. Gupta and colleagues have developed an algorithm for prediction of sleep apnea based upon patients with previously diagnosed sleep apnea. The results of this study were presented at the most recent Scientific Session of the Heart Rhythm Society and are currently being validated prospectively by enrolling patients in a prospective trial (NASSA-ICD) utilizing data collected from ICDs during sleep studies in patients with undiagnosed sleep apnea. 2013 Research Annual Repor t // Central Office of Research Administration 9 informed treatment decisions. The results of this study were presented at the annual scientific sessions of the American College of Cardiology. • Mikhail Kosiborod, M.D., continues to advance the field of cardiometabolism, and led a number of impactful research studies in 2013. Along with Suzanne Arnold, M.D., M.H.A., he served as lead author of the TERISA study, a multi-national randomized clinical trial that evaluated the effectiveness of ranolazine in reducing angina among patients with Type 2 diabetes and chronic stable coronary artery disease. The results of the study were presented as a late-breaking clinical Mikhail Kosiborod, M.D. trial at the American College of Cardiology Congress in March and subsequently published in the Journal of the American College of Cardiology (JACC). Dr. Kosiborod is also a pioneer in developing our understanding of the role of continuous glucose monitoring (CGM) technology in the management of critically ill patients undergoing cardiac surgery. As principal investigator of an industry-sponsored study for its newly developed CGM system, Sentrino, Saint Luke’s MAHI was the first institution worldwide to study this device in patients after cardiac surgery. It was also the first time CGM was evaluated in patients undergoing cardiac transplantation. The results of this study were presented at the International Symposium on Intensive Care and Emergency Medicine in Brussels, Belgium, in March 2013. • James H. O’Keefe, M.D., continues to publish extensively in the areas of cardiovascular prevention, health and nutrition. Most recently, he has been focused on understanding the potential cardiovascular dangers of chronic excess endurance exercise – a syndrome termed “cardiac overuse injury.” In collaborative projects with experts from around the world involving tens of thousands of people followed for decades, he has found moderate intensity exercise is among the very best thing one can do for long-term cardiovascular health and longevity; excess exercise when done over years to decades can predispose to heart problems over time. Several of Dr. O’Keefe’s widely cited papers this year deal with the CV benefits of coffee and tea, the importance of fatty liver disease as a potent reversible CV risk factor, and a meta-analysis showing that the over-the-counter supplement L-carnitine improves prognosis after MI. Lipid Diabetes Research Center (LDRC) Inflammation is now considered an integral component of atherothrombosis, leading to heart attack, stroke, and peripheral artery disease, especially in high risk individuals, such as with hypertension, smoking, elevated cholesterol, and especially diabetes.Yet to date no clinical trial has been completed to determine whether inhibiting inflammation may reduce cardiovascular events. Alan Forker, M.D., Medical Director, LDRC The Lipid Diabetes Research Center (LDRC) is involved in two new multicenter trials trying to answer this question. One is the CANTOS trial, utilizing canakinumab, a human monoclonal antibody that neutralizes the bioactivity of interleukin-1 beta, a primary cytokine promoting inflammation. In addition to the standard medications given post-myocardial infarction, quarterly canakinumab subcutaneous injections will be given to patients with continued elevation of inflammatory markers after MI. The trial will enroll 17,000 patients worldwide in 1,400 study centers with the goal to prevent recurrent cardiovascular events. The second trial is CIRT* (Cardiovascular Inflammation Reduction Trial), funded by the NIH. This trial takes a different approach than CANTOS—directly testing an approved anti-inflammatory drug, methotrexate, given in low dose, 15-20 mg orally once a week. Seven thousand patients in the United States and Canada will be enrolled in this multicenter trial with the goal of reducing recurrent myocardial infarction and stroke in patients with a previous MI or at high risk of a future cardiovascular event. In addition to these novel studies of inflammation, the LDRC continues to be involved in a large number of other studies involving patients with hypertension, gout, obesity, and several diabetes trials. One unique trial involves the use of a tiny titanium metal tube placed under the skin to release a long-acting form of the drug, exanatide, in order to improve glucose control. The LDRC added a new investigator this year, Fredric Regenstein, M.D., a hepatologist, who is interested in testing new approaches to treat hepatitis C. Lipid and Diabetes Research: 18 active studies 276 patients enrolled 10 2013 Research Annual Repor t // Central Office of Research Administration * Refer to page 59 Saint Luke’s Cancer Institute Providing cancer patients access to leading clinical trials Timothy J. Pluard, M.D. Medical Director Rakesh Gaur, M.D., M.P.H., FACP Director of Medical Oncology Research The Saint Luke’s Cancer Institute (SLCI) research program assures access to an extensive range of studies in many cancer specialties. Oncology patients treated at Saint Luke’s Health System metro facilities have the opportunity to participate in disease-specific clinical studies. These include National Cancer Institute (NCI) Cooperative Research Group trials, pharmaceutical industrysponsored research, and investigator-initiated trials (IITs). Through the evaluation of promising investigational treatments from these clinical studies, Saint Luke’s oncology patients and their physicians are provided options for care that otherwise would not be available. SLCI partners with major pharmaceutical and biotech companies, as well as prominent academic and medical research institutions throughout the United States. During 2013, SLCI was a contracted clinical site for a wide variety of industry sponsored trials, and it continually evaluates new protocols to initiate at Saint Luke’s Health System campuses. Saint Luke’s is a leading member of the Kansas City Clinical Lowell Byers, M.D. Oncology Program (KCCOP), Director of Gynecologic an NCI grant-funded initiative. Oncology Research For 30 years, the KCCOP has facilitated regional patient access to national Cooperative Research Group clinical trials. This aligns with and advances the important national cancer strategy to expand access to and increase enrollment in cancer clinical trials. Rakesh Gaur, M.D., KCCOP principal investigator, works with the KCCOP leadership staff, member institutions, and regional investigators who conduct cancer research through a dynamic portfolio of treatment and control trials. 2013 Highlights •T o provide greater responsiveness for cancer patients and physician investigators and to support growing study enrollment, SLCI expanded research nurse coverage to full time at Saint Luke’s East Hospital. This helps SLCI ensure the clinical research team is active in identifying whether a research trial is a good option for each patient. •The Saint Luke’s Cord Blood Program has collected 8,300 total units since the program’s inception in 2008. This program serves as a worldwide resource for children and adults who need a stem cell transplant. Through 2013, 10 of these units have been transplanted into patients with acute myeloid leukemia, myelodysplastic syndrome, and Fanconi’s anemia. • Saint Luke’s Cell Processing Laboratory continued processing blood samples for research protocols, processed cells for a clinical stem cell protocol for critical limb ischemia, and submitted its first grant application for the study of cord blood biopreservation. • Timothy J. Pluard, M.D., joined SLCI in 2013 as both medical director and practicing clinician. Dr. Pluard aims to elevate the Cancer Institute regionally and nationally, and aggressively pursue research opportunities and clinical trials. Prior to joining Saint Luke’s, he was institutional principal investigator for the National Surgical Adjuvant Breast and Bowel Project. The National Cancer Institute (NCI) has recognized Dr. Pluard among the national top accruers in cooperative group trials. • Rakesh Gaur, M.D., chief of hematology-oncology, continues to contribute numerous oncology publications. Dr. Gaur serves on the National Cancer Institute (NCI) Leukemia Steering Saint Luke’s Cancer Committee, which Institute Research: is primarily responsible for 102 active studies evaluating and approving clinical 309 patients enrolled trials in leukemia and myelodysplastic 9 publications syndrome. 5 abstracts/presentations 2013 Research Annual Repor t // Central Office of Research Administration 11 Saint Luke’s Marion Bloch Neuroscience Institute Kansas City’s leading neuroscience research center provides patients with outcomes on par with the nation’s elite programs Darren Lovick, M.D. Co-director, Surgical Charles Weinstein, M.D. Co-director, Medical (Interim) The three pillars of Saint Luke’s Marion Bloch Neuroscience Institute are clinical research that brings the latest in technology and therapy to patients; public and professional education; and clinical excellence. Together, they guarantee excellent outcomes for the care we provide and attract exceptional, well-trained clinicians who want to practice in a vibrant and inquisitive environment. In January 2013, the new Neuroscience Institute opened with 88,000 square feet on six floors. It includes 68 private rooms and an 18-bed neurointensive care unit. The four neurosurgical suites and two neurointerventional suites are equipped with the latest technology. Later in the year, the fourth floor opened, adding an additional 20 private rooms. The new facility has helped attract subspecialty-trained physicians and nurses to the Neuroscience Institute. Work is underway to establish a neurocritical care service. Clinical and translational research are part of each Neuroscience Institute program. Many clinicians are publishing sponsored or original research in peerreviewed journals and presenting on the national stage at professional society meetings. 2013 Highlights • S aint Luke’s was honored to receive a very generous $12 million gift from the Marion and Henry Bloch Family Foundation to support neuroscience programs and outcomes research. The gift, the single largest ever received by Saint Luke’s, will support expanded programming for Saint Luke’s Marion Bloch Neuroscience Institute, whose performance in neurology and neurosurgery was recently recognized by U.S. News & World Report, and for Saint Luke’s internationally recognized center for outcomes research. 12 • D arren Lovick, M.D., and Charles Weinstein, M.D., were named co-directors of Saint Luke’s Marion Bloch Neuroscience Institute. • K arin Olds, M.D., was named interim medical director for the Stroke Program. • Collaborative projects are underway with Stanford University* and The Johns Hopkins Medical Institutions.* The Stanford project is developing technology to better identify which ischemic stoke patients might benefit from intra- arterial stroke treatment. The Johns Hopkins project involves hemorrhagic stroke treatment options that could aid in recovery. • N eurological Interventional Radiologists Naveed Akhtar, M.D., William Holloway, M.D., and Coleman Martin, M.D., presented at a conference in London about their research on retrieving clots for the treatment of stroke patients. • T he team was well represented at the International Stroke Conference. Poster presenters included: Joyce Dorssom, A.P.R.N., Brenda Jones, A.P.R.N., Katie Taylor, A.P.R.N., Debbie Summers, A.P.R.N., Marilyn Rymer, M.D., and Shelleen King, B.S.N. Debbie Summers presented a platform presentation at the International Stroke Conference Nursing Symposium. • D onna Hunt, M.S.N., Mary Fowler, A.P.R.N., Traci Wheeler, B.S.N., and Rachel Malloy, B.S.N., were platform presenters at the American Association of Neuroscience Nurses 2013 National Conference. • T he March of Dimes 2013 Future of Nursing Award recipients included two Neuroscience Institute nurses. Saint Luke’s Marion Bloch Advanced Practice: Debbie Neuroscience Institute Research: Summers, R.N., M.S.N., 22 active studies AHCNS-BC, CNRN, SCRN, 129 patients enrolled and Medical/ Surgical: 7 publications Adrienne L. Patterson, R.N., 16 abstracts/presentations M.S.M., CNRN. 2013 Research Annual Repor t // Central Office of Research Administration * Refer to page 59 Saint Luke’s Midwest Ear Institute Research Saint Luke’s Midwest Ear Institute continues to be a national leader in cochlear implants. In 2013, new, thinner electrode arrays designed to preserve the delicate structures of the inner ear became available, as well as new speech processors. With this new technology, patients who have better preservation of inner ear structures have better speech perception outcomes. Robert Cullen, M.D. Medical Director 2013 Highlights • The Ear Institute had the highest enrollment among 10 clinical sites in the United States for the study “Evaluation of the Nucleus Hybrid L24 Cochlear Implant System.” This device was submitted to the Food and Drug Administration (FDA) for a pre-market approval in 2013, and one of our subjects was asked to participate at the FDA panel. In November 2013, the FDA Advisory Committee met and unanimously agreed the device was safe and effective, and benefits outweighed risks. • I n a related study, the 10 subjects who were enrolled in the L24 Study have been able to benefit from the advanced features of one of the new cochlear implant processors, the Cochlear America’s Nucleus 6 System. In a study entitled, “Evaluation of the Nucleus® Hybrid™ L24 Cochlear Implant System, IDE Supplement: Investigation of Nucleus 6 Sound Processor Signal Processing Algorithms,” subjects can use the new processor for a one month period. The subjects are tested with their old processor and the new processor initially, and then complete further testing and questionnaires about the benefits they receive after one month. At the conclusion, they continue use of the new processor. • E ar Institute audiologists have designed an investigator-initiated trial, “Optimal Hearing Aid Parameters for Maximizing Performance in Bimodal Cochlear Implant Users,” to determine the best way to program a hearing aid with a cochlear implant to make sound more balanced. Many patients with cochlear implants can benefit from a hearing aid in their contralateral ears, giving them “bimodal” hearing and better ability to hear in noise and to know the location of sound. The results of this study will ensure patients reach their maximum hearing potential. 2013 Research Annual Repor t // Central Office of Research Administration 13 Diagnostic and Interventional Radiology Focus on improved patient outcomes through investigator-initiated research The Department of Radiology continues to pursue investigator-initiated research projects with the goal of improved patient outcomes. Research efforts have resulted in outside funding from the biotechnology industry as well as the Kansas Bioscience Authority. Jeff Kunin, M.D. Department of Radiology Chairman 2013 Highlights • Jeff Kunin, M.D., continued his investigator-initiated study, “The Role of EarlyCDT®-Lung in the Management of Pulmonary Nodules,” with co-investigators from the Departments of Radiology, Pulmonary Medicine, and Cardiology. This innovative study is evaluating and correlating human autoantibodies targeting lung cancer with pulmonary nodules found on computed tomography (CT) scans with a simple blood test called EarlyCDT®- Lung. This blood test has the potential to distinguish benign from malignant pulmonary nodules. There are 117 patients currently enrolled. The study is funded by Health Diagnostic Laboratory Inc. (formerly Oncimmune), the Kansas Bioscience Authority, and Saint Luke’s Foundation. • • In Dr. Borsa’s research, CT is being used to evaluate the tilt of IVC filters. IVC filter tilt may have implications in filter efficacy as well as filter retrieval. • With the completion of enrolled-patient follow-up, Interventional Radiology’s role in the ATTRACT* (Acute Venous Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis) study led by Dr. Wible will come to a close. The NIH-funded, Phase III, multicenter clinical trial was designed to compare post-thrombotic syndrome (PTS), quality-of-life, cost-effectiveness, and safety of pharmacomechanical catheter-directed thrombolysis (PCDT) versus conventional therapy for treatment of DVT. • Saint Luke’s Hospital of Kansas City is the only hospital in the Kansas City region that employs radiologists with expertise in dedicated interpretation of thoracic imaging. Radiologist subspecialists, recognized at national and international levels, are utilizing two to three decades of imaging expertise to lead the multidisciplinary team of lung cancer experts in the 2013-initiated Saint Luke’s Hospital of Kansas City Lung Cancer Screening Program. Patients screened in this program receive low-dose chest CT scans and the advantage of diagnostic and treatment expertise from a host of medical specialists at Saint Luke’s. Two interventional radiologists, Brandt C. Wible, M.D., and John Borsa, M.D., FRCPC, are leading three investigator-initiated studies. Each research project focuses on inferior vena cava (IVC) filters. • Dr. Wible’s first study is comparing filter removal success rates for two IVC filters commonly used throughout Kansas City, with a goal of better understanding IVC filter designs to aid with filter placement decisions. His second study strives to improve IVC filter retrieval rates in general by changing filter-placement and follow-up patient-scheduling practice patterns. 14 2013 Research Annual Repor t // Central Office of Research Administration Interventional Radiology Research: 5 active studies 404 patients enrolled 22 publications 21 abstracts/presentations * Refer to page 59 Henry & Marion Bloch Liver Disease Management & Transplant Center Multifaceted expertise caring for patients The Henry & Marion Bloch Liver Disease Management & Transplant Center provides convenient access to comprehensive diagnostic and therapeutic services to patients with liver disease and hepatobiliary malignancy. In addition to its superb team of physicians and health care professionals, the center offers access to advanced treatment modalities, including the opportunity to participate in clinical research trials. 2013 HIGHLIGHTS Hepatology & Liver Transplantation The Liver Transplant Program received endorsement of the team’s expertise by achieving certification by the Centers for Medicare and Medicaid (CMS). CMS certification status enables Saint Luke’s to augment the exceptional care provided to patients with end-stage liver disease through its comprehensive program. Saint Luke’s liver specialists and cardiologists have discovered a compelling association between non-alcoholic fatty liver disease (NAFLD) and a high risk for cardiovascular disease. Remarkable findings resulted from a research study led by Liver Disease Management Center gastroenterologists John Helzberg, M.D., and Rajiv Chhabra, M.D., with collaboration from Saint Luke’s Mid America Heart Institute cardiologists James O’Keefe, M.D., and Randall Thompson, M.D. The research findings were published in Mayo Clinic Proceedings. disease. The center currently has five active clinical trials evaluating new treatments for patients with chronic hepatitis C and chronic liver disease. Vascular Access Christie Gooden, M.D., transplant surgeon, led a team evaluating a novel technique for performing dialysis access grafts. The new technique in the HeRO project allowed for dialysis access grafts to be used sooner, decreasing the length of time patients relied on catheters for dialysis and the potential risk of infection. The findings were published in The Scientific World Journal. Saint Luke’s is currently the only center in the metropolitan region performing HeRO grafts. Renal Transplantation • P erformed the first combined kidney-liver transplant at Saint Luke’s Hospital • A chieved 100 percent one-month patient and graft survival and 96 percent six-month patient and graft survival Therapeutic Endoscopy Saint Luke’s was selected as one of 12 U.S. research sites to participate in a clinical trial evaluating a novel endoscopic suturing device for the treatment of obesity. The study, which will begin enrolling patients in 2014, will be led by principal investigator Sreeni Jonnalagadda, M.D., FASGE, section chief of gastroenterology at Saint Luke’s. Multicenter clinical research trials, led by Fredric Regenstein, M.D., medical director of the Henry & Marion Bloch Liver Disease Management & Transplant Center, provide access to promising innovative therapies for patients with chronic liver 2013 Research Annual Repor t // Central Office of Research Administration 15 Nursing Staff has active role in collaborative projects impacting patient outcomes Saint Luke’s Hospital nurses are empowered to conduct research to expand their knowledge and implement evidence-based strategies to improve patient care. Nurses can participate in nursing research through a unit-based program or independently. 2013 Highlights Jacque Carpenter, R.N., Ph.D. Nursing Research Program Director Saint Luke’s Hospital Nursing Research Award Effects of Night-Time Napping on Attention and Satisfaction in Nurses on the Night Shift Janet Emerson, R.N. Saint Luke’s Hospital Evidence-Based Practice Award Improving Therapeutic Hypothermia Marci Ebberts, R.N. Unit-Based Research Program The Unit-Based Nursing Research (UBR) Program enables a team of staff nurses to collaborate on a research project with the help of a team leader and a research mentor. Each research team formulates a researchable question by consensus, designs a research project, and disseminates the results. This program has increased the accessibility of research to the bedside nurse. Nursing Research Clinical Scholar Program Initiated in 2012, the Nursing Research Clinical Scholar (NRCS) Program continued to gain momentum in 2013. This program is designed for staff nurses who want to conduct investigatorinitiated clinical research. The NRCS program provides multiple opportunities for a select group of nurses to engage in scholarly research activities, including development and implementation of a research project. Funds donated to Saint Luke’s Foundation provide financial support that enabled the clinical scholars to participate in nursing research activities. One of the clinical scholars, Katie Jaschke, presented her research at Saint Luke’s Hospital 2013 Research Day. Her project was titled “Nurses’ Perceived Barriers to and Suggested Interventions for Providing High Quality End-of-Life Care.” 2013 Clinical Scholar Projects • E xamining the Effect of Cardiac Inpatients’ Perception of Fall Risk on the Intent to Participate in Fall Prevention Interventions (Cheryl Radar, CVICU) • E xploring What Motivates Individuals to Seek Non-emergent Medical Treatment (Karen Mollus, ED) 2013 Unit-Based Research Projects • C omparison of the Effects of Incentive Spirometry on Dyspnea and Vital Capacity in Hospitalized Pneumonia Patients (Yinghong Moore, E3) • D oes Speed of Drawing Mixed Venous Oxygen Saturation Affect Results? (Katie Jaschke, CICU) • C omparison of Two Inpatient Educational Methods in the Heart Failure Patient (Deb Negus, Saint Luke’s College of Health Sciences) • E ffects of Patient Position on Pulmonary Functioning Mechanically Ventilated Patients (Donna Hunt, NSICU) 16 2013 Research Annual Repor t // Central Office of Research Administration Nursing Research: 11 active studies 599 patients enrolled 2 publications 17 abstracts/presentations Pharmacy Acclaim at the regional, national, and international level As a result of its investigator-initiated trials in 2013, Saint Luke’s Health System Pharmacy Departments made a number of important contributions to the health system’s efforts to improve and standardize patient care processes. Examples include: • Developing order sets in collaboration with Saint Luke’s Care to optimize the use of intravenous iron products and to direct the use of procalcitonin as a guide for the discontinuation of antimicrobial therapy in pneumonia patients •W orking with the Blood Bank and Neuroscience Evidence-Based Practice Team to develop order sets and modified dosing parameters for four-factor prothrombin concentrate for the management of warfarin-induced intracranial hemorrhage • Assessing the impact of pharmacy discharge education on readmission rates for acute myocardial infarction patients •W orking with the health system’s Antimicrobial Stewardship Committee to develop mechanisms to track longitudinal changes in antimicrobial expenditures and their impact on resistance pattern in our hospitals Patrick Kelly, Pharm.D., and Nick Bennett, Pharm.D., BCPS, won first place in the Allied Health Division at Saint Luke’s Research Day for their project titled “Impact of ProcalcitoninGuided Antibiotic Therapy in Pneumonia and COPD Exacerbations in an Academic Community Hospital Setting.” Annie Pounders, Pharm.D.; Joe Blunck, Pharm.D.; BCPS; and Jeannette Ploetz, Pharm.D., BCPS, were recognized with the honorable mention award in the Allied Health Division at Saint Luke’s Research Day for their project titled “Evaluation of a Pharmacist-Driven Protocol for the Discontinuation of Inappropriate Stress Ulcer Prophylaxis.” Jeff Little, Pharm.D., M.P.H., BCPS, received the Distinguished Service Award from the New Practitioner’s Section of the American Society of Health-System Pharmacists at the ASHP Midyear Clinical Meeting in Orlando in December 2013. Greg Teale, Pharm.D., BCPS Pharmacy Director, Saint Luke’s Health System Mark Woods, Pharm.D., FASHP, BCPS Clinical Coordinator and Residency Program Director 2013 Highlights Stephanie Burton, Pharm.D., BCPS; Kelly Galen, Pharm.D., BCPS; and Kedra Blunck, Pharm.D., BCPS; won the Missouri Society of Health-System Pharmacist (MSHP) Research and Education Foundation’s Original Research Award for their project “Evaluation of the Effect of Pharmacist Education on Acute Myocardial Infarction Readmission Rates” at the MSHP Annual Meeting in St. Louis. Saint Luke’s Pharmacy Department has won this award 11 of the past 13 years. Emily Huedepohl, Pharm.D., and Mark Woods, Pharm.D., FASHP, BCPS, were runners up for the MSHP Research and Education Foundation Original Research Award with their project titled “Impact of Individualized Feedback on Medication Barcode Scan Rates.” Spencer Pummell, Pharm.D., BCPS, and Scott Aldridge, Pharm.D., BCPS, were recognized as the Outstanding Research Poster Presentation at the Kansas Council of Health-System Pharmacists meeting in Wichita for their project titled “Evaluation of Intravenous Iron Sucrose Prescribing After the Implementation of a Mandatory Order Set Across a Four Hospital System.” 2013 pharmacy residents Pharmacy Research: 5 active studies 2,984 patients enrolled 2 publications 26 abstracts/presentations 2013 Research Annual Repor t // Central Office of Research Administration 17 Anesthesiology UNIVERSITY OF MISSOURI – KANSAS CITY ■ SCHOOL OF MEDICINE UMKC medical residents recognized for research achievements at regional and local levels The academic Department of Anesthesiology at the University of Missouri–Kansas City has grown to more than 60 clinical faculty at three institutions (Saint Luke’s Hospital of Kansas City, Truman Medical Center, and Children’s Mercy Hospitals and Clinics), in addition to five research faculty located at the University of Missouri–Kansas City School of Medicine and Kansas City University of Medicine and Bioscience. Research and scholarly activity are requirements of the anesthesiology residency review committee of the Accreditation Council for Graduate Medical Education (ACGME). Exploration of new knowledge keeps the faculty on the leading edge of new advances, stimulates inquiry, and promotes quality patient care. It is also an important educational tool for residents’ learning and for their academic development. 2013 Highlights • E .E. Fibuch, M.D., was president of the Association of Midwest Academic Anesthesiology Chairs (an association of 32 academic anesthesiology departments located in the Midwest and extending into Canada). • E .E. Fibuch, M.D., headed the planning committee for the 2013 Midwest Anesthesia Residency Conference. 550 scientific abstracts from 32 academic programs were presented. • E .E. Fibuch, M.D., was elected fellow in the American College of Physician Executives and the American Board of Quality Assurance and Utilization Review Physicians. • T he residency program underwent a RRC site visit in February resulting in a five-year accreditation (which was then extended to a 10year accreditation cycle in June 2013) without citation. • A dam Reese, M.D., became the second anesthesiology program director in the history of the residency program as Dr. Fibuch transitioned from this position after 36 years. • C hris Wang, M.D., fourth-year anesthesiology resident, was awarded second place in the basic science section at the 2013 Midwest Anesthesia Residency Conference for his research entitled “Differential Regulation of Behavioral Sensitivity to Acute and Chronic Cocaine Administration by Acid-Sensing Ion Channel 1a and 2 in Adult Mice.” • A dam Reese, M.D., was accepted into the Medical Management Masters program at Carnegie Mellon University. • A ndrew Montalbano, M.D., fourth-year anesthesiology resident, was awarded first place in the basic science section of Saint Luke’s Research Day for his research titled “Isoflurane Enhances the Moonlighting Activity of GAPDH: Implications for GABAa Receptor Trafficking.” E.E. Fibuch, M.D., CPE, CHCQM, FACPE, FABQAURP Professor and Chairman • A dam Reese, M.D., was certified by the American College of Physician Executives as a physician executive (CPE). • E .E. Fibuch, M.D., co-directed the first Physician Leadership Program for the University of Missouri—Kansas City. It is a conjoint leadership training program sponsored by the School of Medicine and the Bloch School of Management designed to train the next generation of physician leaders. 18 2013 anesthesiology residents 2013 Research Annual Repor t // Central Office of Research Administration Women & Children Research enhances comprehensive perinatal and neonatal services Saint Luke’s Health System delivers more babies than any other health system in Kansas City, and its flagship, Saint Luke’s Hospital, has delivered babies for more than a century. Saint Luke’s Hospital’s maternal fetal medicine offers the area’s highest level of perinatal care for expectant moms who are considered high-risk and a level IIIb NICU, which promotes best outcomes for tiny babies. of infants with severe ROP. Findings will enable clinicans to identify factors that may increase the risk of blindness and other adverse outcomes in premature infants. High-Risk Obstetrics George Lu, M.D., Perinatologist Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes Neonatology Katherine Claflin, M.D., Neonatologist Study Registry for Severe Retinopathy and Treatment on Visual Outcomes of Premature Neonates Several recent studies have generated significant concern about how to best prevent retinopathy of prematurity (ROP), and how to best treat severe ROP when it develops. This study’s purpose is to monitor the influence of the prescribed care on outcomes and determine what factors influence the visual outcomes This national study concluded enrollment at the end of 2013. The research project explored the question of whether to remove a cerclage after premature preterm rupture of membranes (PPROM). This question is one of the unresolved controversies in obstetrics because few studies are available or have conflicting results. The combination of PPROM in a patient with cerclage in place is a rare complication, making it difficult to study in medical centers not staffed by perinatologists. Spiritual Wellness Clinical Pastoral Education Advanced Ministry Saint Luke’s Health System’s Clinical Pastoral Education Program requires its chaplain residents to conduct a research project addressing a particular health and spirituality subject. These projects offer a theologically informed spiritual care strategy for the care of patients, family, and staff directly affected by a particular health-related subject, such as trauma, stroke, heart conditions, palliative care, cancer, or ethical issues. In 2013, Chaplain Residents Kristin Austin, Phyllis Flory, Tim Maguffee, and Judy Sneegas completed a research study exploring how nurses’ perceptions of the chaplain’s role impact the integration of chaplain services and other Spiritual Wellness resources into patient, family, and staff care. The study identified a gap between nurses’ perception of the role of chaplain and how chaplains perceive their role as health care professionals. The study had three recommendations: • T he Spiritual Wellness Department should provide continuing education to all members of patient care teams about when, why, and how to make referrals to chaplains. • Chaplains should be integrated into patient care teams, including attending rounds, discharge planning, team meetings, etc. Chaplains should be intentional about developing relationships with nursing staff. • T he Spiritual Wellness Department should provide online resources that address nurses’ issues of concern, such as spiritual resources related to different faith traditions. Marc Giedinghagen, D.Min. Director of Clinical Pastoral Education 2013 Research Annual Repor t // Central Office of Research Administration 19 Saint Luke’s Hospital Institutional Review Board Group protects human subjects from undue risk during investigations The Saint Luke’s Hospital Institutional Review Board (IRB) reviews research involving human subjects. Its goals are protecting human subjects from undue risk during the course of scientific investigations and fulfilling requirements of federal regulations governing such research. IRB meetings occur twice monthly January through October and once monthly in November and December. Saint Luke’s IRB—Very Responsive The Saint Luke’s Hospital IRB is known for being very responsive and for its prompt turnaround. Submission deadlines for IRB meetings are typically three weeks prior to each meeting. This amount of time allows for processing of the studies in the IRB office, distribution of information to IRB members, and review by members prior to the meetings. Following IRB meetings, correspondence regarding status of IRB review is normally completed within a few days. Pharmaceutical and medical device companies often comment on the efficiency of Saint Luke’s IRB and the four-week turnaround of IRB decisions, which is almost unheard of in the research industry. The IRB is composed of individuals devoted to assuring the ethical conduct of research within Saint Luke’s Health System. IRB Members • Alan Forker, M.D., Chair • Diana Dark, M.D., Vice Chair • Sharon Bell, R.Ph. • Jeremy Burd, M.D. • Jacque Carpenter, R.N., Ph.D. • Jennifer Elliott, M.D. • Rakesh Gaur, M.D. • Karl Hanson, M.D. • Marilyn Horn, CIP, IRB Administrator • Rev. Jerry Kolb • Anthony Magalski, M.D. • Ellen McDowell, R.N., M.S.A. • Henry Randall, M.D. • Jim Silber, community member • Sandy Silva, Esq. Number of Active Studies 2009–2013 450 400 • Marci Ebberts, R.N., B.S.N., C.C.R.N. (alternate for Jacque Carpenter) • Tarris Rosell, Ph.D. (alternate for Sandy Silva) 350 300 Affiliates for review of research at their respective sites: 250 200 • Kathy Harms, Ph.D., Crittenton Children’s Center 150 • Shauna Todd, R.N., Saint Luke’s East Hospital 100 • Jeff Eye, R.N., M.S.N., Saint Luke’s North Hospital 50 0 2009 20 Alternate: 2010 2011 2012 2013 • J ulia Woods, R.N., M.S.N., Saint Luke’s South Hospital 2013 Research Annual Repor t // Central Office of Research Administration 2013 Research Day Saint Luke’s Hospital researchers earn recognition for their work at annual event Saint Luke’s Hospital 2013 Research Day, held May 3, showcased a variety of projects, including: • 1 5 from medical residents and fellows • 7 by Pharm.D. residents • 8 by nursing teams (an additional 13 uncompleted projects were introduced by displays) • 4 from medical staff/allied health professionals The purpose of Research Day is to showcase studies conducted by medical residents and fellows, along with projects of professional staff. The high-quality, intellectually stimulating work of many talented professionals was highlighted and encompassed numerous specialties, such as: • Anesthesiology • C ardiovascular • C ritical Care • G astroenterology • I nternal Medicine • N eurology • Nursing • O ncology • P harmacology • Radiation Oncology Both basic research (“bench research” in a lab setting) and clinical research (research with human subjects) were represented. Many of these Saint Luke’s research projects competed nationally and received awards within their specialties. 2013 Research Annual Repor t // Central Office of Research Administration 21 2013 Research Day Winners Basic Research First Place — Andrew Montalbano, M.D., Anesthesiology Resident Honorable Mention — Alisa Likhitsup, M.D., Internal Medicine Resident GAPDH-Mediated GABBA Receptor Trafficking Enhanced by Volatile Anesthetics Staining for Liver Oxidative Stress in Obese Mouse Module Clinical Research 22 First Place — Natalie Jayaram, M.D., Cardiology Outcomes Research Fellow Honorable Mention — Faraz Kureshi, M.D., Cardiology Outcomes Research Fellow Hospital Variation in Survival for Pediatric In-Hospital Cardiac Arrest: A Report from Get With the Guidelines – Resuscitation Variability in Patient Misperceptions on the Indications and Benefits of PCI in Stable Coronary Artery Disease Within and Across Centers 2013 Research Annual Repor t // Central Office of Research Administration Allied Health First Place — Patrick M. Kelley, Pharm.D., Pharm.D. Resident Honorable Mention — Annie Pounders, Pharm.D., Pharm.D. Resident Impact of Procalcitonin-Guided Antibiotic Therapy in Pneumonia and COPD Exacerbations in an Academic Community Hospital Setting Evaluation of a Pharmacists-Driven Protocol for the Discontinuation of Inappropriate Stress Ulcer Prophylaxis Nursing Research Nursing Evidence-Based Practice First Place — Janet Emerson, R.N., Principal Investigator First Place — Marci Ebberts, R.N., B.S.N., CCRN Improving Therapeutic Hypothermia Effect of Napping on Perception of Sleepiness and Selective Attention/Concentration in Nurses on Night Shift 2013 Research Annual Repor t // Central Office of Research Administration 23 Scholarly Activities, Publications and Abstracts & Presentations Saint Luke’s investigators’ work contributes to leading-edge treatment options for patients and the body of knowledge for clinicians around the world. 24 2013 Research Annual Repor t // Central Office of Research Administration 2013 Scholarly Activities Allen KB. Annals of Thoracic Surgery. Invited Reviewer. Butrick C. Obstetrics and Gynecology Journal, Reviewer. Allen KB. Circulation. Invited Reviewer. Chan P. Abstract Grading Committee, American College of Cardiology Scientific Sessions. Grader. Allen KB. FDA. Circulatory Device Panel Member. Allen KB. INNOVATIONS. Invited Reviewer. Allen KB. International Society of Minimally Invasive Cardiothoracic Surgeons. Board of Directors. Allen KB. Journal of Cardiovascular & Thoracic Surgery. Invited Reviewer. Bateman T. American Society of Nuclear Cardiology. Scientific Meeting Planning Committee. Bateman T. International Conferences of Nuclear Cardiology. Program Planning Committee. Bateman T. Subspecialty Board on Cardiovascular Disease, American Board of Internal Medicine. Member. Bennett N. American Society of Health-System Pharmacists, Section of Clinical Specialists and Scientists, Clinical Leadership Committee, Member. Bennett N. American Society of Health-System Pharmacists, Student Society Advisor, Drake University School of Pharmacy. Borsa JJ. American Journal of Radiology, Invited Manuscript Reviewer. Borsa JJ. Journal of Endovascular Therapy, Invited Manuscript Reviewer. Borsa JJ. Journal of Vascular and Interventional Radiology, Invited Manuscript Reviewer. Borsa JJ. Radiology, Invited Manuscript Reviewer. Borsa JJ. Society of Interventional Radiology, Technology Assessment Committee, Member. Buchanan DM. Circulation: Cardiovascular Quality and Outcomes. Ad Hoc Reviewer. Butrick C. American Journal of Obstetrics and Gynecology, Reviewer. Butrick C. International Urogynecology Journal, Reviewer. Butrick C. Journal of Female Pelvic Medicine and Reconstructive Surgery, Reviewer. Butrick C. Journal of Sexual Medicine, Reviewer. Butrick C. Journal of Urology, Reviewer. Chan P. Abstract Grading Committee, American Heart Association Resuscitation Science Conference. Grader. Chan P. Abstract Grading Committee, American Heart Association Scientific Sessions. Grader. Chan P. American College of Cardiology National Cardiovascular Disease Registry (NCDR) Science and Quality Oversight Committee. Committee Member. Chan P. American College of Cardiology PINNACLE Registry Research and Publications Committee. Committee Member. Chan P. American Heart Association Get with the Guidelines Adult Research Task Force. Chair. Chan P. American Heart Association Get with the Guidelines Steering Committee. Committee Member. Chan P. American Heart Association Get with the Guidelines-Resuscitation. Vice-Chair of Research. Chan P. American Heart Association Social Determinants of Health Committee. Member. Chan P. American Heart Journal. Invited Journal Reviewer. Chan P. American Journal of Cardiology. Invited Journal Reviewer. Chan P. Chest. Invited Journal Reviewer. Chan P. Circulation. Invited Journal Reviewer. Chan P. Conference Planning Committee for American Heart Association Conference on Quality of Care and Outcomes. Committee Member. Chan P. Critical Care Medicine. Invited Journal Reviewer. Chan P. European Heart Journal. Invited Journal Reviewer. Chan P. Journal of the American College of Cardiology. Invited Journal Reviewer. Chan P. Journal of the American Medical Association. Invited Journal Reviewer. Chan P. New England Journal of Medicine. Invited Journal Reviewer. 2013 Research Annual Repor t // Central Office of Research Administration 25 Chan P. Resuscitation. Invited Journal Reviewer. Chhatriwalla AK. Cardiovascular Revascularization Medicine. Ad Hoc Reviewer. Chhatriwalla AK. Circulation: Quality and Outcomes Research. Ad Hoc Reviewer. Chhatriwalla AK. Clinical Cardiology. Ad Hoc Reviewer. Chhatriwalla AK. International Journal of Cardiology. Ad Hoc Reviewer. Chhatriwalla AK. Journal of Cardiology and Therapy. Editorial Board. Chhatriwalla AK. Trends in Cardiovascular Medicine. Ad Hoc Reviewer. Cohen DJ. ACCF/AHA Task Force on Practice Guidelines/Task Force on Performance Measures Cost Methodology Paper. Peer Reviewer. Cohen DJ. AHA Council on Clinical Cardiology, Interventional Cardiovascular Care Committee. Member. Cohen DJ. American Heart Journal. Editorial Board. Cohen DJ. Cardiology Today Intervention. Editorial Board. Cohen DJ. Cardiovascular Intervention Medicine. Editorial Board. Cohen DJ. Circulation. Editorial Board. Cohen DJ. Circulation. Peer Reviewer. Cohen DJ. Circulation: Cardiovascular Quality and Outcomes. Editorial Board. Cohen DJ. Coronary Artery Disease. Editorial Board. Cohen DJ. Research and Publications Committee, ACC-STS Transcatheter Valve Therapy Registry. Member. Cohen DJ. Steering Committee, TRANSLATE-ACS Trial (DCRI). Member. Day K. Greater Kansas City Society of HealthSystem Pharmacists, Immediate Past-President and Board of Directors. Friedell M. ACGME Association of Program Directors in Surgery (APDS) Milestones Committee, Member. Friedell M. American College of Surgeons Assessment of Preparation for Intern Readiness in Surgery (ASPIRES) Committee, Member. Friedell M. APDS Nominating Committee, Chairman. Friedell M. Journal of Surgical Education, Editorial Board. Friedell M. Little Red Book Revision Committee, American College of Surgeons Division of Education, Member. Friedell M. Program for Chiefs of Clinical Services, Harvard School of Public Health. Friedell M. Surgical Council on Resident Education (SCORE), APDS representative. Gaddis G. Academic Emergency Medicine, Senior Associate Editor, Decision Editor, and Reviewer. Gaddis G. American Journal of Emergency Medicine, Reviewer. Cohen DJ. EuroIntervention Journal. Editorial Board. Gaddis G. European Journal of Emergency Medicine, Reviewer. Cohen DJ. Journal of Cardiovascular Translational Research. Editorial Board. Gaddis, G. Journal of Emergency Medicine, Reviewer. Cohen DJ. Journal of the American College of Cardiology. Peer Reviewer. Cohen DJ. Journal of the American College of Cardiology: Cardiovascular Interventions. Editorial Board. Cohen DJ. Journal of the American Medicine Association. Peer Reviewer. Cohen DJ. New England Journal of Medicine. Peer Reviewer. 26 Cohen DJ. Publications Committee, TRANSLATEACS Trial (DCRI). Member. Gaddis, G. Med Ed Portal, Reviewer. Gaddis, GM, Graham CA. 7th Mediterranean Emergency Medicine Congress, Research Abstracts Co-Chair. Gaddis, GM. American Academy of Emergency Medicine Scientific Assembly 2013, Research Abstract Contest Judge. Gupta, S. Heart Rhythm Society 34th Annual Scientific Sessions. Section Chair. 2013 Research Annual Repor t // Central Office of Research Administration Haideri N, American Society of Clinical Oncology, Virtual Mentor. Kosiborod M. ACTION-Get With the Guidelines Research & Publications Committee. Member. Kosiborod M. American Heart Association Council on Nutrition, Physical Activity and Metabolism (NPAM) Leadership and Conference Planning Committee. Member. Kosiborod M. American Heart Association Council on Nutrition, Physical Activity and Metabolism (NPAM) Leadership and Conference Planning Committee. Chair. Kosiborod M. American Heart Association National Advocacy Committee. Member. Kosiborod M. American Heart Association’s Committee on Scientific Sessions Planning. QCOR Council Chair. Kosiborod M. KEEP (Kidney Early Evaluation Program) of the National Kidney Foundation, Steering Committee. Member. Kosiborod M. NCQA/AMA-PCPI Joint Diabetes Expert Panel. Panel Participant. Kosiborod M. The Endocrine Society’s Clinical Practice Guideline on the Management of Hyperglycemia in Hospitalized Patients in a NonCritical Care Setting. Member. Kosiborod M. Writing Group: “Contributory Risk and Management of Comorbidities of Hypertension, Obesity, Diabetes, Hyperlipidemia and Metabolic Syndrome in Chronic Heart Failure A Scientific Statement from the American Heart Association”. Member. Kosiborod M. Writing Group: “Prevention of Cardiovascular Disease in People with Type 2 Diabetes in Light of New Evidence: A Scientific Statement from the American Heart Association and the American Diabetes Association”. Member. Lamar J. Greater Kansas City Society of HealthSystem Pharmacists, Program Chair and Board of Directors. Little J. American Society of Health-System Pharmacists, Political Action Committee Advisory Group. Little J. American Society of Health-System Pharmacists, Section of Practice Managers, Manager Development Section Advisory Group. Little J. American Society of Health-System Pharmacists, Student Society Advisor, Creighton University School of Pharmacy. Little J. Kansas Council of Health-System Pharmacists, Treasurer and Board of Directors. Little J. Kansas Pharmacy Technician Advisory Group, Board member. Magalski A. Advanced Heart Failure/Transplant Fourth Year Fellowship Program. Director. Marso S. American College of Cardiology: i2LIVE Program Committee. Member. Marso S. Cardiothoracic Surgical Trials Network (CSTN) Glucose Control Pre-Protocol Development Committee. Member. Marso S. Carotid Artery Revascularization and Endarterectomy (CARE) Registry Committee. Member. Marso S. SCAI Task Force on PCI Quality. Member. Marso S. State of Missouri Time Critical Diagnosis (TCD) Committee. Chairman. Massey L. American Society of Health-System Pharmacists, Section of Practice Managers, Leadership Development Advisory Group Member. Massey L. American Society of Health-System Pharmacists, Student Society Advisor, University of Kansas School of Pharmacy. Massey L. Kansas Council of Health-System Pharmacists, Chair, Governmental Affairs Committee Member. Massey L. Kansas Pharmacy Technician Advisory Group, Chair. Maulik D. Central Association of Obstetrics and Gynecology, Board Member. Maulik D. Journal of Maternal, Fetal and Perinatal Medicine, Editor-in-Chief. Maulik D. Maternal Fetal Medicine Fellowship Program (ABOG Accredited), Program Director. Maulik D. Maternal Fetal Medicine Section, The Global Library of Women’s Medicine, Sapiens Global Library Inc. UK, Consulting editor. Milburn L. National Kidney Disease Education Program, Member, Laboratory Working Group. 2013 Research Annual Repor t // Central Office of Research Administration 27 O’Keefe JH Jr. “For the Heart” Publication from Cardiovascular Consultants. Ten-time winner of Healthcare Advertising Awards National Competition. Editor in Chief. O’Keefe JH Jr. Enhance Magazine. Contributor. O’Keefe JH Jr. Journal of the Missouri State Medical Association. Editorial Board. O’Keefe JH. Living Wellness Kansas City. Contributing Author. Repp K. Missouri Society of Health-System Pharmacists Research and Education Foundation, Board of Directors. Robke J. American Society of Health-System Pharmacists Research and Education Foundation, Immunization Grant Advisory Panel, Member. Rosado de Christenson ML. American Journal of Roentgenology, Manuscript Reviewer. Rosado de Christenson ML. American Roentgen Ray Society, Introduction to Academic Radiology: Developing a Successful Mentoring Relationship. Rosado de Christenson ML. American Roentgen Ray Society, President-Elect; Executive Committee Member; Executive Council Member; Ex Officio Member: CME Review Approval Subcommittee, Program Committee, Outcomes Committee, Global Relations Committee. Rosado de Christenson ML. Mallinckrodt Institute of Radiology, Visiting Professor. Rosado de Christenson ML. Radiologic Pathology Course, American Institute for Radiologic Pathology, Visiting Professor. Rosado de Christenson ML. Society of Thoracic Radiology, President; Chair, Program Committee; Member, CME Review Committee. Spertus JA. ACC NCDR Data Quality Work Group. Member. Spertus JA. ACC NCDR Scientific Oversight Committee. Member. Spertus JA. ACC Oversight Committee on the Development of CMS Outcomes Measures for Quality. Chair. Spertus JA. ACC Presidential Task Force on Performance Assessment, Recognition, Reinforcement, and Reward (PAR3 Task Force). Member. 28 Spertus JA. ACC/AHA Writing Committee for the Stable Ischemic Heart Disease Guidelines. Member. Spertus JA. AMA PCPI/ACC/AHA Collaboration for the Determination of Performance Measures of Quality in Hypertension, Angina and Congestive Heart Failure. Co-Chair. Spertus JA. American College of Cardiology/ Center for Medicare and Medicaid Services 30-day Outcomes Working Group for PCI. Member. Spertus JA. American College of Cardiology/ Center for Medicare and Medicaid Services 30-day Outcomes Working Group for ICD. Member. Spertus JA. American Heart Association QCOR Council Nominating Committee. Chair. Spertus JA. American Heart Association QCOR Council Young Investigator Committee. Chair. Spertus JA. BC Centre for Improved Cardiovascular Health Advisory Board. Member. Spertus JA. Circulation. Associate Editor. Spertus JA. Circulation: Cardiovascular Quality and Outcomes. Deputy Editor. Spertus JA. Executive Steering Committee, VA CHF QUERI. Member. Spertus JA. HMO Research Network Cardiovascular Disease Research Network (HMORN CVRN) External Collaborations and Advisory Committee. Member. Spertus JA. International Scientific Advisory Committee for the Canadian Cardiovascular Outcomes Research Team (C-CORT). Member. Spertus JA. National Quality Forum’s Technical Advisory Panel (TAP) for Heart Disease in its Standardizing Ambulatory Care Performance Measures Project. Member. Spertus JA. NHLBI Protocol Review Committee and DSMB: PROMISE Trial. Member. Spertus JA. Steering Committee IHD QUERI C3P Facilitated Cardiology Consultation Project. Member. Spertus JA. United Healthcare National Cardiac Care Scientific Advisory Board. Member. Spertus JA. Veterans Affairs Ischemic Heart Disease QUERI Executive Committee. Member. Stevens TL. American Heart Association. National Spokesperson. 2013 Research Annual Repor t // Central Office of Research Administration Stevens TL. Heart Health Advisory Board for Woman’s Day. Member. Stevens TL. NHLBI Founding Heart Truth Partner. Stevens TL. NHLBI Heart Truth Community Action Program Grant. Recipient. Stevens TL. The National Coalition for Women with Heart Disease Scientific Advisory Council. Member. Stewart JR. Annals of Thoracic Surgery. Ad Hoc Reviewer. Woods M. American Society of Health-System Pharmacists Research and Education Foundation, Excellence In Residency Awards Evaluation Panel, Member. Woods M. Board of Pharmaceutical Specialties Oncology, Board Member. Woods M. Kansas Council of Health System Pharmacists Research and Education Foundation, Board of Directors, Chair. Woods M. United States Food and Drug Administration, Drug Safety and Risk Management Committee, Member. Thompson RC. American College of Cardiology Coding Task Force. Vice Chair. Thompson RC. American Medical Association CPT Editorial Panel. Alternate Advisor for Cardiology. Thompson RC. American Society of Nuclear Cardiology Scientific Sessions Program Committee. Member. Thompson RC. American Society of Nuclear Cardiology. Board of Directors. Thompson RC. Egyptian Journal of Cardiology, The Anatomical Record, and Global Heart. Ad Hoc Reviewer. Thompson RC. International Congress of Nuclear Scientific Sessions. Program Chair. Thompson RC. Journal of Nuclear Cardiology. Editorial Board. Wall T, National Radiation Oncology Registry, Radiation Oncology Institute and American Society for Radiation Oncology, Executive Committee member. Wible BC. RADPrimer Radiology Learning Portal, Vascular and Interventional Radiology Section. Amirsys electronic publication, Section Team Leader and Editor. Wible BC. RADPrimer Radiology Learning Portal. Amirsys electronic publication, Content Contributor. Wible BC. STATdx Radiologic Decision Support, Vascular and Interventional Radiology Section. Amirsys electronic publication, Content Contributor Wimmer A. Circulation: Arrhythmias and Electrophysiology. Reviewer. Wimmer A. Europace. Reviewer. Wimmer A. Heart Rhythm. Reviewer. 2013 Research Annual Repor t // Central Office of Research Administration 29 2013 Publications ANESTHESIOLOGY Elliott J. Fibuch EE. Endocrine Effects Of Chronic Opioids Therapy: Implications For Clinical Management. An Invited Review. 2013 Pain Management 3(3) 237-246. Fibuch EE, Van Way C. Benchmarking. 2013. Physician Executive Journal Jan-Feb pp28-32. Fibuch EE, Ahmed A. Indexing Performance Measures. 2013 Physician Executive Journal. Nov/Dec pp38-43. Guo ML, Xue B, Jin DZ, Mao LM, Wang JQ (2013) Dynamic Downregulation Of Nogo Receptor Expression In The Rat Forebrain By Amphetamine. Neurochem Int 63:195-200. PMC3735811. Jiang Q, Wang CM, Fibuch EE, Wang JQ, Chu XP. Differential Regulation Of Locomotor Activity To Acute And Chronic Administration In AcidSensing Ion Channels 1 A And 2 In Adult Mice. 2013. Neuroscience. 246:170-178. Jin DZ, Guo ML, Xue B, Fibuch EE, Choe ES, Mao LM, Wang JQ (2013) Phosphorylation and Feedback Regulation of Metabotropic Glutamate Receptor 1 by Camkii. J Neurosci 33:3402-3412. PMC3711744. Jin DZ, Guo ML, Xue B, Mao LM, Wang JQ (2013) Differential Regulation of Camkiiα Interactions With Mglur5 and NMDA Receptors by Ca2+ in Neurons. J Neurochem 127:620-631. Mao LM, Reusch JM, Fibuch EE, Liu Z, Wang JQ (2013) Amphetamine Increases Phosphorylation Of MAPK/ ERK At Synaptic Sites In The Rat Striatum and Medial Prefrontal Cortex. Brain Res 1494:101-108. PMC3546198. Mao LM, Diaz, Diaz, JA, Fibuch EE, Wang JQ (2013) Regulation of Phosphorylation of Synaptic And Extrasynaptic Glua1 AMPA Receptors In The Rat Forebrain by Amphetamine. Eur J Pharmacol 715:164171. Mao LM, Guo ML, Jin DZ, Xue B, Wang JQ (2013) Group III Metabotropic Glutamate Receptors And Drug Addiction. Frontiers of Medicine 7:445-451. Newell B, Fibuch EE, McCartney M. Simulations in Anesthesiology: A Key Element In The New Recertification Process. 2013. Missouri Medicine. March/April, pp 139-141. 30 Newell B, Fibuch EE, McCartney M. Simulations in Anesthesiology: A Key Element In The New Recertification Process. 2013. Missouri Medicine. March/April, pp 139. CANCER INSTITUTE Ma CX, Suman VJ, Goetz M, Haluska P, Moynihan T, Nanda R, Olopade O, Pluard T, Guo Z, Chen HX, Erlichman C, Ellis MJ, Fleming GF. A Phase I Trial Of The IGF-1R Antibody Cixutumumab In Combination With Temsirolimus In Patients With Metastatic Breast Cancer. Breast Cancer Res Treat, 2013 May; 139(1): 145-53. doi: 10.1007/s10549-013-2528-8. Epub 2013 Apr 19. Miranda RN, Aladily TN, Prince HM, Kanagal-Shamanna R, de Jong D, Fayad LE, Amin MB, Haideri N, Bhagat G, Brooks GS, Shifrin DA, O’Malley DP, Cheah CY, Bacchi CE, Gualco G, Li S, Keech Jr JA, Hochberg EP, Carty MJ, Hanson SE, Mustafa E, Sanchez S, Manning Jr JT, Xu-Monette ZY, Miranda AR, Fox P, Bassett RL, Castillo JJ, Beltran BE, de Boer JP, Chakhachiro Z, Ye D, Clark D, Young KH, Medeiros LJ. Breast Implant–Associated Anaplastic Large-Cell Lymphoma: Long-Term Follow-Up of 60 Patients. Journal of Clinical Oncology, 2013 December 09; Published Ahead of Print as 10.1200/ JCO.2013.52.7911. Roop RP, Naughton MJ, Van Poznak C, Schneider JG, Lammers PE, Pluard TJ, Johnson F, Eby CS, Weilbaecher KN. A Randomized Phase II Trial Investigating the Effect of Platelet Function Inhibition on Circulating Tumor Cells in Patients With Metastatic Breast Cancer. Clinical Breast Cancer, 2013; 13(6): 409-15. Sessa C, Shapiro GI, Bhalla KN, Britten C, Jacks KS, Mita M, Papadimitrakopoulou V, Pluard T, Samuel TA< Akimov M, Quadt C, Fernancez-Ibarra C, Lu H, Bailey S, Chica S, Banerji U. First-in-Human Phase I DoseEscalation Study of the HSP90 Inhibitor AUY922 in Patients with Advanced Solid Tumors. Clin Cancer Res, 2013 Jun 11. Youland RS, Schomas DA, et al. Changes In Presentation, Treatment, And Outcomes Of Adult Low-Grade Gliomas Over The Past Fifty Years. Neuro Oncol, 2013 Aug; 15(8):1102-1110. Youland RS, Schomas DA, et al. Prognostic Factors And Survival Patterns In Pediatric Low-Grade Gliomas Over 4 Decades. Journal of Pediatric Hematology/ Oncology, 2013 Apr; 35(3):197-205. 2013 Research Annual Repor t // Central Office of Research Administration EMERGENCY MEDICINE Gaddis GM, Graham CA. Research Abstracts of the Seventh Mediterranean Emergency Medicine Congress. Journal of Emergency Medicine, 2013, 46 (6):958-9. GASTROENTEROLOGY Chhabra R, O’Keefe JH, Patil H, O’Keefe E, Thompson RC, Ansari S, Kennedy KF, Lee L, Helzberg JH. Association of Coronary Artery Calcification With Hepatic Steatosis in Asymptomatic Individuals. Mayo Clinic Proceedings, 2013; 88: 1259-65. MID AMERICA HEART INSTITUTE Abdallah JS, Wang K, Magnuson EA, Spertus JA, Farkouh ME, Fuster V, Cohen DJ. Quality of Life After PCI vs CABG Among Patients with Diabetes and Multivessel Coronary Artery Disease: A Randomized Clinical Trial. JAMA 2013;310:1581-1590. Abramsohn EM, Decker C, Garavalia B, Garavalia L, Gosch K, Krumholz HM, Spertus JA, Lindau ST. “I’m Not Just a Heart, I’m a Whole Person Here”: A Qualitative Study to Improve Sexual Outcomes in Women with Myocardial Infarction. J Am Heart Assoc 2013;2(4):e000199. Abdelfattah A, Allam AH, Wann S, Thompson RC, AbdelMaksoud G, Badr I, Amer HA, El-Din AE, Finch CE, Miyamoto MI, Sutherland L, Sutherland JD, Thomas GS. Atherosclerotic Cardiovascular Disease in Egyptian Women. Int J Cardiol 2013 Jul 31;167(2):570-574. Abuannadi M, Kosiborod M, Riggs L, House J, Hamburg M, Kennedy K, Marso S. Management of Hyperglycemia With the Administration of Intravenous Exenatide to Patients in the Cardiac Intensive Care Unit. Endocrine Practice 2013 Jan;10(1):81-90. Acharjee S, Boden WE, Harztigan PM, Teo KK, Maron DJ, Sedlin SP, Kostuk W, Spertus JA, Dada M, Chaitman BR, Mancini GB, Weintraub WS. Low Levels of High Density Lipoprotein Cholesterol and Increased Risk of Cardiovascular Events in Stable Ischemic Heart Disease Patients: A Post Hoc Analysis from the COURAGE Trial. J Am Coll Cardiol 2013;62(20):1826-1833. Al Badarin FJ, Spertus JA, Gosch KL, Buchanan DM, Chan PS. Initiation of Statin Therapy After Acute Myocardial Infarction is not Associated with Worsening Depressive Symptoms: Insights from the Prospective Registry Evaluating Outcomes After Myocardial Infarctions: Events and Recovery (PREMIER) and Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients’ Health Status (TRIUMPH) Registries. Am Heart J 2013;166(5): 879-886. Allen LA, Spertus JA. End points for Comparative Effectiveness Research in Heart Failure. Heart Fail Clin 2013;9(1):15-28. Althouse AD, Abbott JD, Surron-Tyrrell K, Forker AD, Lombardero MS, Buitron LV, Pena-Sing I, Tardif JC, Mori Brooks M; for the BARI 2D Study Group. Favorable Effects of Insulin Sensitizers Pertinent to Peripheral Arterial Disease in Type 2 Diabetes, Results from the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial. Diabetes Care 2013 Oct;36(10):3269-3275. Amin AP, Bachuwar A, Reid KJ, Chhatriwalla AK, Salisbury AC, Yeh RW, Kosiborod M, Wang TY, Alexander KP, Cohen DJ, Spertus JA, Bach RG. Nuisance Bleeding with Prolonged Dual Antiplatelet Therapy After Acute Myocardial Infarction and its Impact on Health Status. J Am Coll Cardiol 2013;61:2130-2138. Amin AP, House JA, Safley DM, Chhatriwalla AK, Giersiefen H, Bremer A, Hamon M, Baklanov DV, Aluko A, Wohns D, Mathias DW, Applegate RA, Cohen DJ, Marso SP. Costs of Transradial Percutaneous Coronary Intervention. JACC Cardiovasc Interv 2013 Jul 12;6:827-834. Amin AP, Whaley-Connell AT, Li S, Chen SC, McCullough PA, Kosiborod M, on behalf of the Kidney Early Evaluation Program Investigators. The Synergistic Relationship Between Estimated GFR and Microalbuminuria in Predicting Long-term Progression to ESRD or Death in Patients with Diabetes: Results from the Kidney Early Evaluation Program (KEEP). Am J Kidney Dis 2013;61(suppl 2):S12-S23. Arnold SV, Lipska KJ, Li Y, GoyalA, Maddox TM, McGuire DK, Spertus JA, Kosiborod M. The Reliability and Prognosis of In-Hospital Diagnosis of Metabolic Syndrome in the Setting of Acute Myocardial Infarction. J Am Coll Cardiol 2013 Aug 20;62(8):704-708. 2013 Research Annual Repor t // Central Office of Research Administration 31 Arnold SV, Spertus JA, Lei Y, Allen KB, Chhatriwalla AK, Leon MB, Smith CR, Reynolds MR, Webb JG, Svensson LG, Cohen DJ. Use of the Kansas City Cardiomyopathy Questionnaire for Monitoring Health Status in Patients with Aortic Stenosis. Circ Heart Fail 2013;6(1):61-67. Arnold SV, Spertus JA, Lei Y, Green P, Kirtane AJ, Kapadia S, Thourani VH, Herrmann HC, Beohar N, Zajarias A, Mach MJ, Leon MB, Cohen DJ. How to Define a Poor Outcome After Transcatheter Aortic Valve Replacement: Conceptual Framework and Empirical Observations From the Placement of Aortic Transcatheter Valve (PARTNER) Trial. Circ Cardiovasc Qual Outcomes 2013;6(5):591-597. Arnold SV, Spertus JA, Masoudi FA, Daugherty Smaddox TM, Li Y, Dodson JA, Chan PS. Beyond Medication Prescription as Performance Measures: Optimal Secondary Prevention Medication Dosing After Acute Myocardial Infarction. J Am Coll Cardiol 2013;61(19):1791-1801. Baklanov D, Messenger J, Rao S. Reply to the Editor J Am Coll Cardiol 2013 Jun 11;61(23):2394. Baklanov DV, Kaltenbach LA, Marso SP, Subherwal S, Feldman D, Garratt K, Curtis J, Messenger J, Rao S. The Prevalence and Outcomes of Transradial Percutaneous Coronary Intervention for STSegment Elevation Myocardial Infarction: Analysis from the NCDR (2007-2011). J Am Coll Cardiol 2013;61:420-426. Baklanov DV, Kim S, Marso SP, Subherwal S, Rao SV. Comparison of Bivalirudin and Radial Access Across a Spectrum of Preprocedural Risk of Bleeding in Percutaneous Coronary Intervention: Analysis From the National Cardiovascular Data Registry. Circ Cardiovasc Intervention 2013 Aug;64):347-353. Bangalore S, Pencina MJ, Kleiman NS, Cohen DJ. Prognostic Implications of Procedural vs Spontaneous Myocardial Infarction: Results from the EVENT Registry. Am Heart J 2013 Dec;166(6):1027-1034. Beller GA, Bateman TM. Provisional Use of Myocardial Perfusion Imaging in Patients Undergoing Exercise Stress Testing: A Worthy Concept Fraught with Challenges. J Nucl Cardiol 2013 Oct;20(5):711-714. Bhatti SK, DiNicolantonio JJ, Captain BK, Lavie CJ, Tomek A, O’Keefe JH. Neutralizing the Adverse Prognosis of Coronary Artery Calcium. Mayo Clin Proc 2013 Aug;88(8):806-812. 32 Bhatti SK, O’Keefe JH, Hagan JC III, Lavie CJ. The Lady Doth Protest Too Much, Methinks. MO Med 2013 JanFeb;110(1):17-20. Bhatti SK, O’Keefe JH, Lavie CJ. LTE Reply-Of Mice and Men: Atrial Fibrillation in Veteral Endurance Runners. J am Coll Cardiol 2013 Sep. Bhatti SK, O’keefe JH, Lavie CJ. Cofee and Tea: Perks for Health and Longevity? Curr Opin Clin Nutr Metab Care 2013 Nov;16(6):688-697. Biffi M, Exner DV, Ramza B, Coutu B, Tomassoni G, Kranig W, Li S, Kristiansen N, Voss F. Occurrence of Phrenic Nerve Stimulation in Cardiac Resynchronization Therapy Patients: The Role of Left Ventricular Lead Type and Placement Site. Europace 2013 Jan;15(1):77-82. Bin Abdulhak AA, Khan AR, Tleyjeh IM, Spertus JA, Sanders SU, Steigerwalt KE, Garbati MA, Bahmaid RA, Wimmer AP. Safety and Efficacy of Interrupted Dabigatran for Peri-Procedural Anticoagulation in Catheter Ablation of Atrial Fibrillation: A systematic Review aNd Meta-analysis. Europace 2013 15(10):1412-1420. Bin Abdulhak AA, Tleyjeh IM, Wimmer A. Dabigatran in the Setting of Catheter Ablation of Atrial Fibrillation: The Road Ahead. Heart 2013. Bishawi M, Shroyer AL, Rumsfeld JS, Spertus JA, Baltz JH, Collins JF, Quin JA, Almassi GH, Grover FL, Hattler B. Changes in Health-related Quality of Life in OffPump versus On-Pump Cardiac Surgery: Veterans Affairs Randomized On/Off Bypass Trial. Ann Thorac Surg 2013;95(6):1946-1951. Borden WB, Spertus JA, Mushlin AI, Roe MT, McCoy LA, Redberg RF. Antianginal Therapy Before Percutaneous Coronary Intervention. Circ Cardiovasc Interv 2013;6(4):436-443. Buchanan DM, Spertus JA. A Leading Postdoctoral Fellowship Training Program in Cardiovascular Outcomes Research. EP Lab Digest 2013;13(11):40-42. Bybee KA, Stevens TL. Matters of the Heart: Cardiovascular Disease in U.S. Women. Missouri Medicine 2013 Jan/Feb;110(1):65-70. Cannon CP, Brindis RG, Chaitman DJ, Cohen DJ, Cross JT, Drozda JP, Fesmire FM, Fintel DJ, Fonarow GC, Fox KA, Gray DT, Harrington RA, Hicks KA, Hollander JE, Krumholz H, Labarthe DR, Long JB, Mascette AM, Meyer C, Peterson ED, Radford MJ, Roe MT, Richmann 2013 ACCF/AHA Key Data Elements and Definitions for Measuring the Clinical Management and Outcomes of Patients with Acute Coronary Syndromes and 2013 Research Annual Repor t // Central Office of Research Administration Coronary Artery Disease: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Acute Coronary Syndromes and Coronary Artery Disease Clinical Data Standards). Circ 2013;127:1053-1089 (Published Simultaneously in J Am Coll Cardiol and Critical Pathways in Cardiol). Case JA, Bateman TM. Taking the Perfect Nuclear Image: Quality Control, Acquisition, and Processing Techniques for Cardiac SPECT, PET and Hubrid Imaging. J Nucl Cardiol 2013 Oct;20(5):891-907. Chamberlain AM, McNallan SM, Dunlay SM, Spertus JA, Redfield MM, Moser DK, Kane RL, Weston SA, Roger VL. Physican Health Status Measures Predict Allcause Mortality in Patients with Heart Failure. Circ Heart Fail 2013;6(4):669-675. Chan PS, Berg RA, Spertus JA, Schwamm LH, Bhatt DL, Fonarow GC, Heidenreich PA, Nallamothu BK, Tang F, Merchant RM. Risk-Standardizine Survival for In-Hospital Cardiac Arrest to Facilitate Hospital Comparisons. J Am Coll Cardiol 2013;62(7):601-609. Chan PS, Nallamothu BK, Krumholz HM, Spertus JA, Li Y, Hammill BG, Curtis LH. Long-Term Outcomes in Elderly Survivors of In-Hospital Cardiac Arrest. N Engl J Med 2013;368(11):1019-1026. Chan PS, Rao SV, Bhatt DL, Rumsfeld JS, Gurm HS, Nallamothu BK, Cavender MA, Kennedy K, Spertus JA. Patient and Hospital Characteristics Associated with Inappropriate Percutaneous Coronary Interventions. J Am Coll Cardiol 2013;62(24):22742281. Chan PS, Spertus JA, Nallamothu BK. Long-term Outcomes in Elderly Survivors of Cardiac Arrest. N Engl J Med 2013;368(25):2438-2439. Chen LM, Nallamothu BK Spertus JA, Li Y, Chan PS. Association Between a Hospital’s Rate of Cardiac Arrest Incidence and Cardiac Arrest Survival. J Am Med Assoc Intern Med 2013;173(13):1186-1195. Chen LM, Nallamothu BK, Krumholz HM, Spertus JA, Tang F, Chan PS. Association Between a Hospital’s Quality Performance for In-Hospital Cardiac Arrest and Common Medical Conditions. Circ Cardiovasc Qual Outcomes 2013; 6(6):700-707. Chhabra R, O’Keefe JH, Patil H, O’Keefe E, Thompson RC, Ansari S, Kennedy KF, Lee LW, Helzberg JH. Association of Coronary Artery Calcification with Hepatic Steatosis in Asymptomatic Individuals. Mayo Clin Proc 2013 Nov;88(11):1259-1265. Chhatriwalla AK, Amin Ap, Kennedy KF, House JA, Cohen DJ, Rao SV, Messenger JC, Marso SP; National Cardiovascular Data Registry. Association Between Bleeding Events and In-Hospital Mortality Following Percutaneous Coronary Intervention. JAMA 2013 Mar 13;309:1022-1029. Cullom SJ, Case JA, Courter SA, McGhie AI, Bateman TM. Regadenoson Pharmacologic Rubidium-82 PET: A Comparison of Quantitative Perfusion and Function to Dipyridamole. J Nucl Cardiol 2013 Feb;20(1):76-83. Dharmarajan K, Masoudi FA, Spertus JA, Li SX, Krumholz HM. Contraindicated Initiation of Beta-Blocker Therapy in Patients Hospitalized for Heart Failure. J Am Med Assoc Intern Med 2013;173(16):1547-1549. DiNicolantonio JJ, Lavie CJ, Fares H, Menezes AR, O’Keefe JH, Bangalore S, Messerli FH. Metaanalysis of Cilostazol versus Aspirin for the Secondary Prevention of Stroke. Am J Cardiol 2013 Oct;112(8):1230-1234. DiNicolantonio JJ, Lavie CJ, Fares H, Menezes AR, O’Keefe JH. Meta-analysis of Carvediolol versus Beta-1 Selective Beta-blockers (Atenolol, Bisoprolol, Metoprolok, and Nebivolol). Am J Cardiol 2013 Jan;111(5):765-769. DiNicolantonio JJ, Lavie CJ, Fares H, Menezes AR, O’Keefe JH. L-carnitine in the Secondary Prevention of Cardiovascular Disease: Systematic Review and Meta-analysis. Mayo Clin Proc 2013 Jun;88(6):544-551. In Reply 2013 Aug;88(8):806-812. DiNicolantonio JJ, Lavie CJ, O’Keefe JH. Not All Angiotensin-converting Enzyme Inhibitors are Equal: Focus on Ramipril and Perindopril. Postgrad Med 2013 Jul;125(4):154-158. DiNicolantonio JJ, McCarty MF, Lavie CJ, O’Keefe JH. Do Omega-3 Fatty Acids Cause Prostate Cancer? MO Med 2013 Jul-Aug;110(4):293-295. DiNicolantonio JJ, Niazi AK, Lavie CJ, O’Keefe JH, Ventura HO. Thiamine Supplementation for the Treatment of Heart Failure: A Review of the Literature. Congest Heart Fail 2013 Jul;19(4):214-222. DiNicolantonio JJ, Niazi AK, Lavie CJ, O’Keefe JH. Problems with the American Heart Association Presidential Advisory Advocating Sodium Restriction. Am J Hypertens 2013 Oct;26(10):1201-1204. 2013 Research Annual Repor t // Central Office of Research Administration 33 DiNicolantonio JJ, O’Keefe JH, Lavie CJ. Statin Wars: The Heavyweight Match-Atorvastatin Versus Rosuvastatin for the Treatment of Atherosclerosis, Heart Failure, and Chronic Kidney Disease. Postgrad Med 2013 Jan;125(1):7-16. DiNicolantonio JJ, O’Keefe JH, Lavie CJ. LTE Reply - The Pleiotropic Effects of Habitual Coffee Consulption. J Am Coll Cardiol 2013 Oct. DiNicolantonio JJ, O’Keefe, Lavie CJ. Chlorthalidone versus Hydrochlorothiazide. Ann Intern Med 2013 Jun;158(12):920-921. Dorian P, Burk C, Mullin CM, Bubien R, Godejohn D, Reynolds MR, Lakkireddy DR, Wimmer AP, Bhandari A, Spertus J. Interpreting Changes in Quality of Life in Atrial Fibrillation: How Much Change is Meaningful? Am Heart J 2013;166(2):381-387 e8. Draznin B, Gilden J, Golden SH, Inzucchi SE; PRIDE Investigators, Baldwin D, Bode BW, Boord JB, Braithwaite SS, Cagliero E, Dungan KM, Falciglia M, Figaro MK, Hirsch IB, Klonoff D, Korytkowski MT, Kosiborod M, Lien LF, Magee MF, Masharani U, Maynard G, Mc Pathways to Quality Inpatient Management of Hyperglycemia and Diabetes: A Call to Action. Diabetes Care 2013 Jul;36(7):1807-1814. Ellerbeck EF, Spertus JA. Let’s Clear the Air for Casino Patrons and Employees. Circ 2013;128(8):783-784. El-Refai M, Peterson EL, Wells K, Swadia T, Sabbah HN, Spertus JA, Williams LK, Lanfear DE. Comparison of Beta-Blocker Effectiveness in Heart Failure Patients with Preserved Ejection Fraction versus Those with Reduced Ejection Fraction. J Card Fail 2013;19(2):73-79. Enriquez JR, de Lemos JA, Parikh SV, Peng SA, Spertus JA, Holper EM, Roe MT, Rohatgi A, Das SR. Association of Chronic Lung Disease with Treatments and Outcomes Patients with Acute Myocardial Infarction. Am Heart J 2013;165(1):43-49. Fatemi O, Paranilam J, Rainow A, Kennedy K, Choi J, Curlip D, Pencina M, Berger PB, Cohen DJ, Kleiman NS. Red Cell Distribution Width is a Predictor of Mortality in Patients Undergoing Percutaneous Coronary Intervention. J Thromb Thrombolysis 2013 Jan;35(1):57-64. Feldman DN, Swaminathan RV, Kaltenbach LA, Baklanov DV, et al. Adoption of Radial Access and Comparison of Outcomes to Femoral Access in Percutaneous Coronary Intervention: An Updated Report from the National Cardiovascular Data Registry (20071012). Circ 2013;127:2295-2306. 34 Finfer S, Wernerman J, Preiser JC, Cass T, Desaive T, Hovorka R, Joseph JI, Kosiborod M, Krinsley J, Mackenzie I, Mesotten D, Schultz MJ, Scott MG, Slingerland R, Van den Berghe G, Van Herpe T. Clinical Review: Consensus Recommendations on Measurement of Blood Glucose and Reporting Glycemic Control in Critically Ill Adults. Crit Care 2013 Jun 13;17(3):229. Fowler VG, Allen KB, Moreira ED, Moustafa M, Isgro F, Boucher HW, Corey R, Carmeli Y, Betts R, Hartzel JS, Chan I, McNeely TB, Kartsonis NA, Guris D, Onorato MT, Smugar SS, DiNubile MJ. Effect of an Investigational Vaccine for Preventing Staphylococcus Aureau Infections After Cardiothoracic Surgery: A Randomized Trial JAMA 2013;309(13):1368-1378. Flint KM, Matlock DD, Sundareswaran KS, Lindenfeld J, Spertus JA, Farrar DJ, Allen LA. Pre-operative Health Status and Outcomes after Continuous-flow Left Ventricular Assist Device Implantation. J Heart Lung Transplant 2013;32(12):1249-1254. Girotra S, Chan PS. Trends in Survival After In-Hospital Cardiac Arrest. N Engl J Med 2013;368(7):680-681. Girotra S, Spertus JA, Li Y, Berg RA, Nadkarni VM, Chan PS. Survival Trends in Pediatric In-Hospital Cardiac Arrests: An Analysis from Get With the Guidelines-Resuscitation. Circ Cardiovasc Qual Outcomes 2013;6(1):42-49. Givertz MM, Teerlink JR, Albert NM, Westlakd Canary CA, Collins SP, Colvin-Adams M, Ezekowitz JA, Fang JC, Hernandez AF, Katz SD, Krishnamani R, Stough WG, Walsh MN, Butler J, Carson PE, Dimarco JP, Hershberger RE, Rogers JG, Spertus JA, Stevenson WG, Swe Acute Decompensated Heart Failure: Update on New and Emerging Evidence and Directions for Future Research. J Card Fail 2013;19(6):371-389. Goldberger ZD, Chan PS, Cooke CR, Hayward RA, Krumholz HM, Nallamothu BK. Duration of Resuscitation Efforts and Survival After InHospital Cardiac Arrest - Authors’ Reply. Lancet 2013;381(9865):447. Gordon PC, Cohen DJ, Kleiman NS, Montgomery JA, Semder CA, Kennedy KF, Keyes MJ, Piana RN; on behalf of the EVENT Investigators. In-Hospital and One Year Outcomes with Drug-eluting versus Bare Metal Stents in Large Native coronary Arteries, a Report from the Evaluation of Drug-eluting Stents and Ischemic Events (EVENT) Registry. 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Joseph SM, Novak E, Arnold SV, Jones PG, Khattak H, Platts AE, Davila-Roman V, Mann DLm Spertus JA. Comparable Performance of the Kansas City Cardiomyopathy Questionnaire in Heart Failure Patients with Preserved and Reduced Ejection Fraction. Circ Heart Fail 2013;6(6):1139-1146. Kappetein AP, Head SJ, Genereux P, Piazza N, van Mieghem NM, Blackstone EH, Brott TG, Cohen DJ, Cutlip DE, van Es GA, Hahn RT, Kirtane AF, Krucoff MW, Kodali S, Mack MJ, Mehran R, Rodes-Cabau J, Vranckx P, Webb JG, Windecker S, Serruys PW, Leon MB. Updated Standardized Endpoint Definitions for Transcatheter Aortic Valve Implantation: The Valve Academic Research consortium-2 Consensus Document. J Thorac Cardiovasc Surg 2013 Jan;145(1): 6-23. Karrowni W, Li Y, Jones PG, Cresci S, Abdallah MS, Lanfear DE, Maddox TM, McGuire DK, Spertus JA, Horwitz PA. Insulin Resistance is Associated with Significant Clinical Atherosclerosis in Nondiabetic Patients with Acute Myocardial Infarction. Arterioscler Thromb Vasc Biol 2013;33(9):2245-2251. Kosiborod M, Arnold SV, Spertus JA, McGuire DK, Li Y, Yue P, Ben-Yehuda O, Katz A, Jones PG, Olmsted A, Belardinelli L, Chaitman BR. Evaluation of Ranolazine in Patients with Type 2 Diabetes Mellitus and Chronic Stable Angina: Results from the TERISA Randomized Clinical Trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects with Chronic Stable Angina). J Am Coll Cardiol 2013;61(20);:2038-2045. Kramer DB, Kennedy KF, Noseworthy PA, Buxton AE, Josephson ME, Normand SL, Spertus JA, Zimetbaum PJ, Reynolds MR, Mitchell SL. Characteristics and Outcomes of Patients Receiving New and Replacement Implantable CardioverterDefibrillators: Results from the NCDR. Circ Cardiovasc Qual Outcomes 2013;6(4):488-497. Krumholz HM, Barreto-Filho JA, Jones PG, Li Y, Spertus JA. Decision-making Preferences Among Patients with an Acute Myocardial Infarction. J Am Med Assoc Intern Medf 2013;173(13):1252-1257. 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Carotid Artery Stenting of a Contralateral Occlusion and In-Hospital Outcomes: Results From the CARE (Carotid Artery Revascularization and Endarterectomy) Registry. JACC Cardiovasc Interv 2013;6(1):59-64. Merchant FM, Zheng H, Bigger T, Steinman R, Ikeda T, Pedretti RF, Salerno-Uriarte JA, Klersy C, Chan PS, Bartone C, Hohnloser SH, Ruskin JN, Armoundas AA. A Combined Anatomic and Electrophysiologic Substrate Based Approach for Sudden Cardiac Death Risk Stratification. Am Heart J 2013;166(4):744-752. 2013 Research Annual Repor t // Central Office of Research Administration Miller AL, Gosch K, Daugherty SL, Rathore S, Peterson PN, Peterson ED, Ho PM, Chan PS, Lanfear DE, Spertus JA, Wang TY. Failure to Reassess Ejection Fraction After Acute Myocardial Infarction in Potential Implantable Cardioverter/Defibrillator Candidates: Insights from the Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients’ Health Status (TRIUMPH) Registry. 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Whaley-Connell AT, Kurella Tamura M, Jurkovitz CT, Kosiborod M, McCullough PA. Advances in CKD Detection and Determination of Prognosis: Executive Summary of the National Kidney Foundation Kidney Early Evaluation Program (KEEP) 2012 Annual Data Report Executive Summary. Am J Kidney Dis 2013;61(suppl 2):S1-S3. Williams JB, Alexander KP, Morin JF, Langlois Y, Noiseux N, Perrault LP, Smolderen K, Arnold SV, Eisenberg MJ, Pilote L, Monette J, Bergman H, Smith PK, Afilalo J. Preoperative Anxiety as a Predictor of Mortality and Major Morbidity in Patients aged >70 Years Undergoing Cardiac Surgery. Am J Cardiol 2013 Jan 1;111(1):137-142. NEUROSCIENCE INSTITUTE Burkart J, Day JS, Henderson K, Borsa J. Efficacy of peripheral interventional radiologists performing endovascular stroke therapy guided by CT perfusion triage of patients. J VascIntervRadiol 2013;24:1267–1272. 40 Stroke Systems of Care: A Policy Statement From the American Heart Association/American Stroke Association. Stroke. 2013 Aug 29. Jauch EC, Saver JL, Adams HP, Bruno A, Connors JJ, Demaerschalk BM, Khatri P, McMullan PW, Qureshi AI, Rosenfield K, Scott PA, Summers D, Wang DZ, Wintermark M and Yonas H. Guidelines for the Early Management of Patients With Acute Ischemic Stroke : A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2013 Mar;44(3):870-947. Rymer MM, Armstrong EP, Meredith NR, Pham SV, Thorpe K, Kruzikas DT. Analysis of the costs and payments of a coordinated stroke center and regional stroke network. Stroke. 2013 Aug;44(8):2254-9. Rymer MM, Armstrong EP, Walker G, Pham S, Kruzikas D. Analysis of a coordinated stroke center and regional stroke network on access to acute therapy and clinical outcomes. Stroke. 2013 Jan;44(1):132-7. Zaidat OO, Castonguay AC, Gupta R, Sun CH, Martin C, Holloway WE, Mueller-Kronast N, English JD, Linfante I, Dabus G, Malisch TW, Marden FA, Bozorgchami H, Xavier A, Rai AT, Froehler MT, Badruddin A, Nguyen TN, Taqi MA, Abraham MG, Janardhan V, Shaltoni H, Novakovic R, Yoo AJ, Abou-Chebl A, Chen PR, Britz GW, Kaushal R, Nanda A, Issa MA, Nogueira RG. North American Solitaire Stent Retriever Acute Stroke registry: postmarketing revascularization and clinical outcome results. J Neurointerv Surg. 2013 Sep 23. NURSING Abramsohn EM, Decker C, Garavalia B, Garavalia L, Gosch K, Krumholz HM, Spertus JA, Lindau ST .I’m Not Just a Heart, I’m a Whole Person Here: A Qualitative Study to Improve Sexual Outcomes in Women with Myocardial Infarction. Journal of the American Heart Association, 2013; July 24; 2(4):e000199. Donovan NJ, Daniels SK, Edmiaston J, Weinhardt J, Summers D, and Mitchell PH, on behalf of the American Heart Association Council on Cardiovascular Nursing and Stroke Council. Dysphagia Screening: State of the Art Invitational Conference Proceeding From the Stateof-the-Art Nursing Symposium, International Stroke Conference 2012. Stroke. 2013 Apr;44(4):e24-31. Rao SC, Chhatriwalla AK, Kennedy KF, Decker C, Gialde E, Spertus JA, Marso, SP. Pre-Procedural Estimate of Individualized Bleeding Risk Impacts Physicians’ Utilization of Bivalirudin during Percutaneous Coronary Intervention. Journal of the American College of Cardiology, 2013; 61(18): 1847-1852. Higashida R, Alberts MJ, Alexander DN, Crocco TJ, Demaerschalk BM, Derdeyn CP, Goldstein LB, Jauch EC, Mayer SA, Meltzer NM, Peterson ED, Rosenwasser RH, Saver JL, Schwamm L, Summers D, Wechsler L, Wood JP; on behalf of the American Heart Association Advocacy Coordinating Committee. Interactions Within Blais D, Zukkoor S, Hayes C, Pickworth K, Porter K, Firstenberg M. Bleeding Outcomes Associated with Coronary Artery Bypass Surgery and Recent Clopidogrel Exposure. The Heart Surgery Forum. 2013;16(2):e70-e77. PHARMACY 2013 Research Annual Repor t // Central Office of Research Administration Shewmaker J. Quetiapine Induced Leukopenia and Neutropenia in an Intensive Care Unit Patient with Delirium and a Review of the Literature. J Pharm Technol 2013;29:9-12. Prescott-Focht JA, Martinez-Jimenez S, Hurwitz LM, Hoang JK, Christensen JD, Ghoshhajra BB, Abbara S. Ascending Thoracic Aorta: Postoperative Imaging Evaluation. Radiographics 2013 Jan; 33(1):73-85. RADIOLOGY Reddy GP, Steiner R, Walker CM. Cardiac Imaging. Case Review Series, 2nd edition. Elsevier. 2013. Abbara S, Walker CM, et al. Diagnostic Imaging: Cardiovascular, 2nd edition. Amirsys. 2013. Primary author of 17 book chapters (126 pages) Benson REC, Rosado de Christenson ML, MartínezJiménez S, Kunin JR, Pettavel PP. Spectrum of Pulmonary Neuroendocrine Proliferations. RadioGraphics 2013; 33:1631-1649. Benson RE, Rosado-de-Christenson ML, MartinezJimenez S, Kunin JR, Watson K, Pettavel PP. Spectrum of Thoracic Neuroendocrine Proliferations and Neoplasms: Carcinoid, Carcinoid Tumorlets, DIPNECH, & Carcinoid Syndrome. RadioGraphics 2013; 33:1631-1649. Retrepo CS, Carrillo J, Rosado de Christenson ML, Ojeda Leon P, Rivera AL, Koss MN. Lymphoproliferative Lung Disorders: A Radiologic-Pathologic Overview. Part II: Neoplastic Disorders. Semin Ultrasound CT MRI 2013; 34: 535-549 Saettele M, Morelli J, Chesis P, Wible BC. Use of a Trellis Device for Endovascular Treatment of Venous Thrombosis Involving a Duplicated Inferior Vena Cava. Cardiovasc Intervent Radiol. 2013 February. PMID: 23370490. Shinn-Huey SS, Walker CM, Chung JH. Ischemic Late Gadolinium Enhancement. J Thorac Imaging. 2013 Sep;28(5):W67-8. Benson REC, Rosado de Christenson ML, Pettavel PP. Author’s Response to Invited Commentary. Radiographics 2013; 33: 1651. Ternes T, Trump M, Rosado de Christenson ML, Howell G, Stewart J. Spontaneous Middle Lobe Torsion. Radiology Case Reports (Online) 2013; 8 (1): 812. Bhatt MY, Martínez-Jiménez S, Rosado de Christenson ML, Watson KR, Walker CM, Kunin JR. Imaging Manifestations of Mediastinal Fat Necrosis. Case Reports in Radiology 2013; Article ID 323579. Walker CM, Saldana DA, Gladish GW, Dicks DL, Kicska G, Mitsumori LM, Reddy GP. Cardiac Complications of Oncologic Therapy. Radiographics 2013 Oct;33(6): 1801-1815. Burkart DJ, Day JS, Henderson K, Borsa JJ. Efficacy of Peripheral Interventional Radiologists Performing Endovascular Stroke Therapy Guided by CT Perfusion Triage of Patients. J Vasc Interv Radiol 2013 Sept;24(9):1267-1272. Walker CM, Reddy GP, Steiner R. Radiology of the Heart. In: Essential Cardiology Principles and Practice. Edited by Rosendorff C. Third Edition. Springer 2013. Carrillo J, Restrepo CS, Rosado de Christenson ML, Ojeda Leon P, Rivera AL, Koss MN. Lymphoproliferative Lung Disorders: A Radiologic-Pathologic Overview. Part I: Reactive Disorders. Semin Ultrasound CT MRI 2013; 34: 525-534. Chhabra R, O’Keefe JH, Patil H, O’Keefe E, Thompson RC, Ansari S, Kennedy KF, Lee L, Helzberg JH. Hepatic Steatosis Independently Predicts The Presence Of Coronary Artery Calcification In Asymptomatic Individuals. Mayo Clinic Proceedings 2013. Jeffrey BR, Manaster BJ, Osborn AG, Rosado de Christenson ML. Diagnostic Imaging Emergency, Second Edition. Salt Lake City. Amirsys, 2013 Martínez-Jiménez S, Heyneman LE. Imaging of the Postoperative Thoracic Aorta. In: Problem Solving in Cardiovascular Imaging. Editors Suhny Abbara MD and Sanjeeva Kalva MD. Elsevier Saunders. 2013. Ngo A, Walker CM, Chung JH, et al. Tumors and Tumor-Like Conditions of the Large Airways. Am J Roentgenol. 2013 Aug;201(2):301-13. Walker CM, Reddy GP. Valves: Magnetic Resonance Imaging. In: Problem Solving in Cardiovascular Imaging. Edited by Abbara S and Kalva SP. Elsevier 2013. Walker CM, Chung JH, Abbott GF, Shepard JO. Reply. Am J Roentgenol 2013 May; 200(5):W541. Walker CM, Reddy GP, Chung JH. Non-Ischemic Delayed Enhancement. Signs in Cardiopulmonary Imaging. J Thorac Imaging. 2013 Mar;28(2):W27. SURGERY Friedell ML, Lambe, B, Bedway, J. Percutaneous Femoral Vein Access for Inferior Vena Cava Filter Placement Does Not Cause Insertion Site Thrombosis. Annals of Vascular Surgery, 2013 Nov; 27(8): 1169-72. Friedell ML. Surgical Resident Allocation: An Art or a Mathematical Formula? Commentary on: An Analytic Decision Support Tool for Resident Allocation. JSE 2013; 70(1): 36. WOMEN AND CHILDREN Maulik, D. Series on Maternal Fetal Medicine, Informa CRC Press, 2007-current. 2013 Research Annual Repor t // Central Office of Research Administration 41 2013 Abstracts & Presentations ANESTHESIOLOGY Diaz JA, Fibuch EE, Mao LM, Wang JQ. Amphetamine Increases Phosphorylation of the Glua1 APMA Receptors in Synaptic and Extrasynaptic Membranes of the Rat Forebrain. MARC. 4-27-13. Kansas City, MO. Edwards MC, Yue B, Mao LM, Fibuch EE, Wang JQ. A Time-Dependent Increase In AMPA Receptor Glua1 Phosphorylation in Confined Synaptic and Extrasynaptic Locations in the Rat Striatum and Prefrontal Cortex. MARC. 4-27-13. Kansas City, MO. Montalbano AJ, Theisen CS, Fibuch EE, Seidler NW. Isoflurane Enhances The Moonlighting Activity Of GAPDH: Implications for Gabaa Receptor Trafficking. MARC. 4-27-13. Kansas City, MO. Reusch JM, Fibuch EE, Mao LM, Wang JQ. Effects of Amphetamine on ERK Phosphorylation in Synaptic and Extrasynaptic Compartments of Rat Striatal and Cortical Neurons. MARC. 4-27-13. Kansas City, MO. Roberts LA, Fibuch EE, Seidler NW. Isoflurane’s Effect on Protein Dynamics: Implications on the Mechanics of Anesthesia. MARC. 4-27-13, Kansas City, MO. Wang CM, Jiang Q, Fibuch EE, Wang JQ, Chu ZP. Differential Regulation of Behavioral Sensitivity to Acute and Chronic Cocaine Administration by AcidSensing Ion Channel 1a And 2 in Adult Mice. MARC. 4-27-13. Kansas City, MO. (Second place in basic science). CANCER INSTITUTE Aft R, Mudalagiriyappa C, Watson M, Pillai S, Fleming T, Trinkaus K, Pluard TJ. [OT1-1-02] A Phase II Randomized Trial Evaluating The Effect Of Trastuzumab On Disease Free Survival In Early Stage HER2-Negative Breast Cancer Patients With ERBB2-Expressing Bone Marrow Disseminated Tumor Cells. San Antonio Breast Cancer Symposium, San Antonio TX, 2013 December 11. Akthar A, Schomas DA, et al. A Retrospective Analysis of Stereotactic Body Radiotherapy (SBRT) in Patients with Stage I Non-Small- Cell Lung Cancer (NSCLC) or Limited Metastatic Disease to Lung. American College of Radiation Oncology Annual Meeting, San Antonio, TX, 2013. 42 Macdonald OK, Schomas DA. Multiple Course Stereotactic Ablative Body Radiotherapy(SABR) for Non-Small Cell Lung Cancer (NSCLC) in Elderly Patients. International Stereotactic Radiotherapy Symposium, Houston, TX, 2013. Sikov WM, Berry DA, Perou CM, Singh B, Cirrincione C, Tolaney S, Kuzma CS, Pluard TJ, Somlo G, Port E, Golshan M, Bellon JR, Collyar D, Hahn OM, Carey LA, Hudis C, Winer EP. Impact of the Addition of Carboplatin (Cb) and/or Bevacizumab (B) to Neoadjuvant Weekly Paclitaxel (P) Followed by Dose-Dense AC on Pathologic Complete Response (Pcr) Rates In Triple-Negative Breast Cancer (TNBC): CALGB 40603 (Alliance). San Antonio Breast Cancer Symposium, San Antonio TX, 2013 December 13. Ward WG, Monn MC. Developing a Current Good Manufacturing Practice (cGMP)-Compliant Cell Therapy Laboratory Culture through a Cycle of Education, Training, Auditing, and Improvement. American Association of Blood Banks Annual Meeting, Denver CO, 2013 October. EMERGENCY MEDICINE Gaddis G. Emergency Department Screening for Sepsis, Central European Congress for Emergency Medicine and Critical Care, Karpacz, Poland, April 2013. Gaddis, G. The Emergency Department: A System within a System. Understanding Patient Thoughput in the Emergency Department, Central European Congress for Emergency Medicine and Critical Care, Karpacz, Poland, April 2013. Gaddis, G. Accomplishing Clinical Research with Limited Funds, Central European Congress for Emergency Medicine and Critical Care, Karpacz, Poland, April 2013. Gaddis, G. Differentiating Non-Inferiority Studies, 7th Mediterranean Emergency Medicine Congress, Marseille, France, September, 2013. Gaddis, G. Pitfalls in Research Methodology. 7th Mediterranean Emergency Medicine Congress, Marseille, France, September, 2013. Gaddis G. Non-emergent Psycho-behavioral Disorders in the ED. Recorded for Audio Digest Emergency Medicine, September, 2013. 2013 Research Annual Repor t // Central Office of Research Administration GASTROENTEROLOGY Chhabra R, O’Keefe JH, Patil H, O’Keefe E, Thompson RC, Ansari S, Kennedy KF, Lee L, Helzberg JH. Hepatic Steatosis is an Independent and a Strong Predictor of Coronary Artery Disease in Asymptomatic Patients, Beyond That Expected from Traditional Framingham Risk Factors and Metabolic Syndrome. American Gastroenterological Association, Orlando, May 2013. HEPATOLOGY AND HEPATOBILIARY SURGERY Poordad F, Rustgi V, Brown R, Patel V, Kugelmas M, Regenstein F, Balart L, LeBrecque D, Brown K, Avila M, Bierderman M, Freed G, Smith R, Bernstein M, Hays A, Cahan J, Fink S, Katakov W, Massoumi M, Harrison S. Boceprevir (BOC) In Community Practice: Interim Results On Early Response And Safety From The OPTIMAL Trial. Presented at the Annual Meeting of the American College of Gastroenterology, San Diego, October, 2013. Brown K, Bacon B, Balart L, Bernstein D, Brown R, Flamm S, Harrison S, Kugelmas M, Kwo P, Lebrecque D, Neff G, Patel V, Reau N, Reddy R, Regenstein F, Schiff E, Shiffman M, Poordad F. Hepatitis C Therapy In Community Practice (OPTIMAL): An Educational Partnership Program Between Academic And Community Practice. Presented at the Annual Meeting of the American College of Gastroenterology, San Diego, October, 2013. Afdhal NH, Reau N, Everson GT, Morelli G, Lok AS, Sherman KE, Dickson RC, Regenstein F, Mean EA, Stewart TG, Fried MW, Pockros P for the HCVTARGET Study Group. Safety and Efficacy of Telaprevir (TPV) or Boceprevir (BOC) in Patients with Cirrhosis: Interim Results of a Longitudinal, Observational Study. American Association for the Study of Liver Diseases. Washington, DC. November 2013 Burden of Angiographic Coronary Disease: A Post Hoc Analysis of the COURAGE Trial. American Heart Association Scientific Sessions. Dallas, TX. November 1620, 2013. Acharjee S, Sidhu MS, Hartigan PM, Teo KK, Spertus JA, Maron D, Weintraub WS, Boden WE. Impact of Angina on Cardiovascular Outcomes in Patients with Stable Ischemic Heart Disease: A Post-Hoc Analysis from the COURAGE Trial. American Heart Association Scientific Sessions. Baltimore, MD. November 16-20, 2013. Allen KB, Borkon AM, Aggarwal S, Haines M, Davis R, Sydzyik T, Pak A, Stewart J, Stuart RS, Allen KE. Venoarterial Extracorporeal Membrane Oxygenation: Simplified Tunneled Technique Using Arterial Grafting and Saphenofemoral Cannulation. ISMICS 2013 Prague, Czech Republic. Innovations 2013;8(2):128. Allen KB, Foreman J, Khicha S, Puggioni A, Borkon AM, Laster S, Aggarwal S, Davis JR, Allen KE. Primary Coarctation of the Aorta Diagnosed in the Older Patient: Endovascular Treatment with Thoracic Covered Stents. ISMICS 2013 Prague, Czech Republic. Innovations 2013;8(2):149. Allen KB, Fowler VG, Gammie JS, Hartzel J, Onorato M, Dinubible M, Sobanjo-Ter Meulen A. Staphylococcus Aureus Infections after Elective Cardiac Surgery: Observations from a Multicenter Placebo-Controlled Trial of an Investigational Vaccine. Infection Disease Society of America San Francisco, CA. October 2-6, 2013. Allen KB. Current Reimbursement and Patientreported Outcomes in Venous Disease: What does the Future Hold? American Venous Forum 25th Annual Meeting Scottsdale, AZ. February 2013. Allen KB. Cardiothoracic and Vascular Surgery: What’s New and Exciting? Greater KC Nurses Association Meeting Kansas City, MO. February 2013. Allen KB. TMR Evidence based Applications and Future Directions. Atlanta, GA. January 2013. MID AMERICA HEART INSTITUTE Abdallah MS, Kosiborod M, Tang F, Karrowni WY, Maddox TM, McGuire DK, Spertus JA, Arnold SV. Patterns and Predictors of Intensive Statin Therapy among Patients with Type 2 Diabetes Mellitus after an Acute Myocardial Infarction. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Acharjee S, Sidhu MS, Hartigan PM, Teo KK, Maron DJ, Sedlin SP, Mancini GBJ, Chaitman BR, Spertus JA, Weintraub WS, Boden WE. Sex-Based Comparison of Angina Severity, Extent of Inducible Ischemia and Allen KB. Decision-making in Critical Limb Ischemia: What a Cardiac Surgeon Needs to Know. Society of Thoracic Surgery Los Angeles, CA. February 2013. Allen LA, Magid DJ, Shetterly S, Peterson PN, Brand DW, Bekelman DB, Clarke CL, Spertus JA, Masoudi FA. Incremental Prognostic Value of Serial Health Status Measures for Ambulatory Patients with Heart Failure. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. 2013 Research Annual Repor t // Central Office of Research Administration 43 Amin AP Bach RG, Kosiborod M, Kennedy K, Tsai TT, Brown JR, Chhatriwalla AK, Cohen DJ, Spertus JA. Large Variation in Contrast Use During PCI - An Important Opportunity for Reducing Acute Kidney Injury. Circ Cardiovasc Qual Outcomes 2013 May;6:A354. Baltimore, MD. May 15-17, 2013. Amin AP, House J, Safley D, Chhatriwalla A, Giersiefen H, Bremer A, Hamon M, Baklanov D, Aluko Y, Wohns D, Mathias D, Applegate R, Cohen D, Marso SP. Costs of Transradial and Transfemoral PCI at Five U.S. Hospitals. J Am Coll Cardiol 2013 Mar;61(10S):210. San Francisco, CA. March 9-11, 2013. Amin AP, Patterson M, House J, Kennedy K, Bremer A, Giersiefen H, Spertus JA, Baklanov D, Chhatriwalla A, Safley D, Cohen D, Rao S, Marso SP. Transradial PCI is Associated with Lower Cost in Medicare Fee-forService Beneficiaries Following Elective PCI. J Am Coll Cardiology 2013, American College of Cardiology 52nd Annual Scientific Sessions. San Francisco, CA. March 9-11, 2013. Amin AP, Shapiro R, Novak E, Olsen M, Singh J, Bach RG, Cohen DJ. Costs of Contrast Induced Acute Kidney Injury. Circ Cardiovasc Qual Outcomes 2013 May;6:A316. Baltimore, MD. May 15-17, 2013. Arnold S, Kirtane A, Kodali S, Zajarias A, Thourani V, Green P, Rodes-Cabau J, Alu M, Lei Y, Mack M, Leon M, Cohen D. Predictors of Poor Outcome After Transcatheter Aortic Valve Replacement in the PARTNER Trial. J Am Coll Cardiology 2013; American College of Cardiology 52nd Annual Scientific Sessions. San Francisco, CA. March 9-11, 2013. Arnold SV, Kosiborod M, Li Y, Jones PG, Yue P, Belardinelli L, Spertus JA. Comparison of the Seattle Angina Questionnaire with Daily Angina Diary Entry. American Heart Association Scientific Sessions. Dallas, TX. November 16-20, 2013. Arnold SV, Kosiborod M, Li Y, Yue P, Ben-Yehuda O, Belardinelli L, Katz A, Jones PG, Olmsted A, Chairman BR, Spertus JA. Effects of Ranolazine on Disease-Specific Health Status and Quality of Life Among Patients with Diabetes and Stable Angina: Results from the TERISA Randomized Trial. American Heart Association Scientific Sessions. Dallas, TX. November 16-20, 2013. Arnold SV, McGuire DK, Lipska KJ, Tang F, Spertus JA, Goyal A, Gore MO, Lanfear DE, Maddox TM, Kosiborod M. Type of Beta Blocker Use Among Patients With versus Without Diabetes after Myocardial Infarction. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. 44 Arnold SV, McGuire DK, Spertus JA, Li Y, Yue P, BenYehuda O, Belardinelli L, Katz A, Jones PG, Olmsted A, Chaitman BR, Kosiborod M. Effectiveness of Ranolazine in Patients with Type 2 Diabetes Mellitus and Chronic Stable Angina According to Baseline Hemoglobin A1c. American Heart Association Scientific Sessions. Dallas, TX. November 16-20, 2013. Arnold SV, Spertus J, Lipska K, Tang F, Goyal A, McGuide D, Cresci S, Maddox T, Kosiborod M. Association of Diabetes Mellitus with Post-Myocardial Infarction Angina: Analysis of the TRIUMPH Prospective Cohort Study. American College of Cardiology Scientific Sessions San Francisco, CA. March 9-11, 2013. Arnold SV, Spertus JA, Alexander KP, Bach RG, Wang TY, Krumholz HM, Li Y, Jones PG, Kosiborod M. HospitalLevel Variability in the Use of Angicoagulant Strategies in a Real-World Population of Patients with Acute Myocardial Infarction. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Arnold SV, Spertus JA, Lei Y, Green P, Kirtane AJ, Kapadia S, Thourani VH, Herrmann HC, Ceohar N, Zajarias A, Mack MJ, Leon MB, Cohen DJ. Defining Futility in Transcatheter Aortic Valve Replacement. Circ Cardiovasc Qual Outcomes 2013 May; 6:A69. Baltimore, MD. May 15-17, 2013. Baklanov D, Tang F, Safley D, Fuss C, Jones P, Spertus J. Short Term Health Status Outcomes and Preferences in Patients Undergoing Elective Transradial Coronary Intervention. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Bateman TM. Is PET Really Better? Comparative Advantages over SPECT, Advances in Nuclear Cardiology and Cardiac CT, Challenges and Opportunities for SPECT and PET in 2013. 28th Annual Case Review with the Experts Los Angeles, CA. January 19, 2013. Bateman TM. PET and CTA: How to Use Hybrid Imaging Effectively. American College of Cardiology 52nd Annual Scientific Sessions. San Francisco, CA. March 11 2013. Bateman TM. Challenges & Opportunities for SPECT and PET in 2013, PET vs SPECT for MPI: Comparative Advantages. 35th Annual Recent Advances in Clinical Nuclear Cardiology & Cardiac CT. Washington, DC. May 8, 2013. 2013 Research Annual Repor t // Central Office of Research Administration Bateman TM. Reducing Radiation While Maintaining Quality, Rubidium-82: Past, Present and Future, A Snapshot of Equipment Utilization in the United States. Society of Nuclear Medicine 2013 Annual Meeting. Vancouver, British Columbia. June 9-13, 2013. Bateman TM. Verani Memorial Lecture: Vision, Leadership & Change, Cardiac Imaging in a Capitated Environment, Cardiac PET Case Presentations, Private Practice Perspective. American Society of Nuclear Cardiology 2013 Annual Meeting. Chicago, IL. September 26-29, 2013. Bateman TM. Strategies and Challenges in the Quest for Reducing Dosimetry for Myocardial Perfusion. Should Your Next Cardiac Camera be a PET Scanner? Rocky Mountain Nuclear Medicine Technologist Annual Meeting. Denver, CO. October 5, 2013. Bateman TM. Positron Emission Tomography: Enhancing the Value of Myocardial Perfusion for Appropriate Patients. Cardiology Grand Rounds Allegheny Health Network. Pittsburgh, PA. October 9, 2013. Bateman TM. Positron Emission Tomography: Enhancing the Value of Myocardial Perfusion for Appropriate Patients. Twelfth Annual Mario S. Verani Memorial Lectureship, Houston Methodist DeBakey Heart and Vascular Center. Houston, TX. October 17, 2013. Bateman TM. Case-Based Face-Off: SPECT vs PET for MPI. American Society of Nuclear Cardiology: Local Learning Initiative. Kansas City, MO. October 24, 2013. Bateman TM. Rubidium-82 Cardiovascular PET and Coronary Flow Reserve. 53rd Annual Japanese Society of Nuclear Medicine. Fukuoka, Japan. November 9, 2013. Bikdeli B, Wang Y, Minges K, Nallamothu BK, Kim N, Desai M, Masoudi FA, Spertus JA, Goldhaber SA, Krumholz HM. Trends in Use of Thrombolytic Therapy among Fee-for-Service Medicare Beneficiaries with Acute Pulmonth Embolism. American Heart Association Scientific Sessions. Dallas, TX. November 16-20, 2013. Bikdeli B, Wayda B, Bao H, Ross J, Xu X, Chaudhry S, Spertus J, Krumholz H. Place of Residence and Outcomes of Patients with Heart Failure: An Analysis from the Tele-HF Trial Participants. American College of Cardiology Scientific Sessions. San Francisco, CA. March 9-11, 2013. Bindra A, Teo K, Sidhu M, Hartigan P, Maron D, Kostuk W, Sedlis S, Mancini GBJ, Bates E, Scirica B, Spertus J, Weintraub W, Chaitman B, Boden W. Prevalence and Clinical Significance of Recurrent and Unremitting Angina with Percutaneous Intervention versus Optimal Medical Therapy in Patients with Stable Ischemic Heart Disease: A Post Hoc Analysis of the Clinical Outcomes Utilizing Revascularizatio American College of Cardiology Scientific Sessions San Francisco, CA. March 9-11, 2013. Bradley SM, Spertus JA, Nallamothu BK, Chan PS, Kennedy KJ, Patel MR, Bryson CL, Malenka DJ, Rumsfeld JS. The Association Between Patient Selection for Diagnostic Coronary Angiography and HospitalLevel PCI Appropriateness: Insights from the NCDR. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Brown PP, Kugelmass A, Reynolds M, Cohen D, Culler S, Simon A. The Incremental Hospital Cost of Treating Major Complications Among Medicare Beneficiaries Undergoing Coronary Artery Bypass Graft Surgery. J Am Coll Cardiology 2013 Mar;61(10S):A397. American College of Cardiology 52nd Annual Scientific Sessions San Francisco, CA. March 9-11, 2013. Buchanan DM, Bennett KK, Reid K, Spertus JA. Cardiac Rehabilitation Referral After Acute Myocardial Infarction: Variation in Referral Rates and Association with Core Components of Risk Factor Management. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Buchanan DM. Patient-Centered Cardiovascular Translational Research: Examples from Genomics to Shared Decision-Making. Patient Centered Translational Discovery Forum, University of Kansas Edwards Campus. Overland Park, KS. November 6, 2013. Chan PS. In-Hospital Cardiac Arrest: An Agenda for the Next Decade. American Heart Association Dickinson W. Richards Memorial Lecturer at AHA Scientific Sessions. Dallas, TX. November 16-20, 2013. Chen J, Wang H, Fazal R, Normand ST, Bradford D, Al-Mallah M, Cohen DJ, Spettell C, Fernandez J, Shaw L, Krumholz HM, Nallamothu BN. Does Higher Use of Non-Invasive Testing Improve the Diagnostic Yield of Coronary Angiography? Circ Cardiovasc Qual Outcomes 2013 Baltimore, MD. May 15-17, 2013. Chen LM, Nallamothu BK, Krumholz HM, Spertus JA, Tang F, Chan PA. Association Between a Hospital’s Quality Performance for In-Hospital Cardiac Arrest and Common Medical Conditions. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. 2013 Research Annual Repor t // Central Office of Research Administration 45 Chhatriwalla AK Cost Analysis: Is It Still Cost Effective to Use Prasugrel or Ticagrelor vs. Generic Clopidogrel? Cardiovascular Research Technology (CRT) 2013 Washington, DC. February 14, 2013. Cohen DJ. Quality of Life After TAVR: What Should you Know? Why Should you Care? Italian Society of Invasive Cardiology Annual Scientific Meeting Genoa, Italy. June 22-26, 2013. Chhatriwalla AK Aortic Stenosis: New Treatment Paradigms. Missouri ACC Chapter Annual Meeting St. Louis, MO. October 5, 2013. Cohen DJ. Improving PCI Quality: Targets for 2013 and Beyond. Principles and Perspectives in Interventional Cardiology Maui, Hawaii. July 15-19, 2013. Chilton RJ, MacConell LA, Han JC, Marso SP. Characterization of Heart Rate Increases with Glucagon-like Peptide-1 Agonist Therapy. American Heart Association Scientific Sessions. Dallas, TX. November 16-20, 2013. Cohen DJ. PARTNER Trial Update: What Have We Learned? Where Are We Going? Principles and Perspectives in Interventional Cardiology Maui, Hawaii. July 15-19, 2013. Cohen DJ. Everolimus Eluting Stents Reduce Stent Thrombosis (Maybe): Challenges of Network Metaanalysis. American College of Cardiology Scientific Sessions/I-2 Summit San Francisco, CA. March 9-11, 2013. Cohen DJ. Controversies in STEMI Management: Universal vs Selective Use of DES American College of Cardiology Scientific Sessions/I-2 Summit San Francisco, CA. March 9-11, 2013. Cohen DJ. ASCERT: Comparative Effectiveness in the Real World American College of Cardiology Scientific Sessions/I-2 Summit San Francisco, CA. March 9-11, 2013. Cohen DJ. Can We Afford TAVR? 18th Annual Angioplasty Summit-TCT Asia Pacific Seoul Korea. April 22-26, 2013. Cohen DJ. Resisting the Bioabsorbable Stent Bandwagon 18th Annual Angioplasty Summit-TCT Asia Pacific Seoul Korea. April 22-26, 2013. Cohen DJ. What’s New in Multivessel Disease: Insights from Recent Clinical Trials 18th Annual Angioplasty Summit-TCT Asia Pacific Seoul Korea. April 22-26, 2013. Cohen DJ. Defining Value in the Cath Lab: Can We Measure it? Can We Improve it? Society for Cardiac Angiography and Intervention (SCAI) National Meeting Orlando, FL. May 7-9, 2013. Cohen DJ. Economics of TAVR: A Global “Gordian Knot” Transcatheter Valve Therapeutics Meeting Vancouver, British Columbia. June 11-13, 2013. Cohen DJ. Can We Afford TAVR? Impact on Hospitals and Health Systems Transcatheter Valve Therapeutics Meeting Vancouver, British Columbia. June 11-13, 2013. Cohen DJ. Barriers to the Adoption of Evidencebased Therapies: The Case of Antiplatelet Therapy Melbourne, Australia. June 13-17, 2013. 46 Cohen DJ. Building a TAVR Program: Insights from the MAHI Experience. Principles and Perspectives in Interventional Cardiology Maui, Hawaii. July 15-19, 2013. Cohen DJ. Improving PCI Outcomes: The Role of Personalized Medicine Australia-New Zealand Endovascular Technologies (ANZET) Meeting Australia. August 4-9, 2013. Cohen DJ. PCI for Chronic CAD: Does It have a Role in 2013? Australia-New Zealand Endovascular Technologies (ANZET) Meeting Australia. August 4-9, 2013. Cohen DJ. How Can We Improve the Costeffectiveness of TAVR for Lower-Risk Patients? London Valves Meeting London, England. September 1517, 2013. Cohen DJ. Invited Speaker 25th Transcatheter Cardiovascular Therapeutics (TCT) Symposium San Francisco, CA. October 2-6, 2013. Cohen DJ. Invited Speaker American Heart Association Annual Scientific Sessions. Dallas, TX. November 16-20, 2013. Decker CJ, Chhatriwalla E, Garavalia B, Spertus JA, Chen E, Gialde E. Differing Perspectives Between Physicians, Patients and Caregivers on the Value of an Individualized Estimate of the Benefits of Thrombolysis at the Time of Acute Ischemic Stroke: Designing The Resolve (Rapid Evaluation for Stroke Outcomes using Lytics i Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Depta J, Lenzini P, Lanfear D, Wang T, Spertus J, Bach R, Cresci S. Clinical Outcomes Associated with Proton Pump Inhibitor use Among ClopidogreloTreated Patients within CYP2C19 /Genotype Groups Following Acute Myocardial Infarction in TRIUMPH Category: Acute Coronary Syndromes, Myocardial Infarction, Thrombectomy and V Society for Cardiovascular Angiography & Interventions Scientific Sessions. Orlando, FL. May 8-11, 2013. 2013 Research Annual Repor t // Central Office of Research Administration Dodson JA, Wang U, Alexander KP), Masoudi F, Spertus JA, Chaudhry SI, Chen J, Nallamothu BK, Arnold SV, Dharmarajan K, Shi R, Krumholz HM. National Trends in Rehospitalization for Bleeding after Acute Myocardial Infarction in Older Patients, 1999-2010. American Heart Association Scientific Sessions. Dallas, TX. November 16-20, 2013. Doll JA, Tang F, Cresci S, Parashar S, Ho M, Spertus JA, Wang TY. Change in Angina Symptom Status after Acute Myocardial Infarction and Its Association with Readmission Risk: An Analysis of the TRIUMPH Registry. American Heart Association Scientific Sessions. Dallas, TX. November 16-20, 2013. Dreyer RP, Smolderen KG, Strait KM, Beltrame JF, Lichtman JH, Lorenze NP, D’Onofrio G, Krumholz HM, Spertus JA. Sex Differences in Pre-Event Health Status of Young Patients with Acute Myocardial Infarction: The VIRGO Study. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Enriquez JR, De Lemos JA, Parikh SV, Holmes D, Wang TY, Chan PS, Spertus JA, Das SR. The Association of Electronic Health Record Use with Acute MI Quality of Care and Outcomes: Results from the NCDR®. American Heart Association Scientific Sessions. Dallas, TX. November 16-20, 2013. Fosbel EL, Peterson E, Honeycutt E, Zettler M, Messenger J, Waksman R, Effron M, Vaitkus P, Cohen D, Wang T. Early Cessation of ADP Receptor Inhibitors Among Acute Myocardial Infarction Patients Treated with PCI: Insights from the TRANSLATE-ACS Study. J Am Coll Cardiol 2013 Mar;61(10S):A394. San Francisco, CA. March 9-11, 2013. Girotra S, Cram P, Spertus JA, Li Y, Jones P, Nallamothu BK, Chan PS. Variation in Survival Trends for InHospital Cardiac Arrest. American Heart Association Scientific Sessions. Dallas, TX. November 16-20, 2013. Grantham JA. Course Co-Director and Faculty Member. 10th International Left Main and Chronic Total Occlusion Summit. New York City, NY. February 4-5, 2013. Grantham, JA. Indication for CTO PCI: Clinical Rationale and Appropriateness. Cardiovascular Research Technology (CRT) 2013 Washington, DC. February 24, 2013. Grantham, JA. Trends in Initial Guidewire Selection for Antegrade and Retrograde Approach Cardiovascular Research Technology (CRT) 2013 Washington, DC. February 24, 2013. Grantham, JA. Complications of CTO PCI II: Perforation - Predictors, Prevention and Management. Cardiovascular Research Technology (CRT) 2013 Washington, DC. February 24, 2013. Grantham, JA. Committee Member, Scientific Session Planning Committee for TCT at ACC 2013, and Faculty Member. American College of Cardiology 2013 Annual Scientific Sessions. San Francisco, CA. March 9-11, 2013. Grantham, JA. Selecting Appropriate Patients for CTO-PCI. TCT-American College of Cardiology 2013 San Francisco, CA. March 9-11, 2013. Grantham, JA. PCI: Successes, Challenges and Implementation. American College of Cardiology 2013 Annual Scientific Sessions. San Francisco, CA. March 9-11, 2013. Grantham, JA. Do we Need BP Device in General CTO-PCI? Nagoya, Japan. May 9, 2013. Grantham, JA. Fight over Knuckle or Tackle? Nagoya, Japan. May 9, 2013. Grantham, JA. Role of Retrograde Approach in Hybrid Approach. Nagoya, Japan. May 9, 2013. Grantham, JA. PCI for CTO is Indicated in Far More Situations than Currently Practiced/Recommended. Complex Cardiovascular Catheter Therapeutics. Orlando, FL. June 19, 2013. Grantham, JA. Changing a Non-dedicated CTO Operator into a Routine CTO Operator. Complex Cardiovascular Catheter Therapeutics. Orlando, FL. June 19, 2013. Grantham, JA. Indications and Appropriateness of CTO PCI Principles and Perspectives in Interventional Cardiology Maui, Hawaii. July 15-19, 2013. Grantham, JA. Antegrade Dissection and Re-Entry Strategies. Principles and Perspectives in Interventional Cardiology Maui, Hawaii. July 15-19, 2013. Grantham, JA. Revascularization: CABG vs PCI: Is There a Right Choice? ACC Missouri Chapter Update in Cardiovascular Disease St. Louis, MO. October 5, 2013. Grantham, JA. CTO PCI Justification: Making the Case with Evidence. TCT 2013 Scientific Committee and Faculty. San Francisco, CA. October 28-31, 2013. Grantham, JA. The Retrograde Approach to CTOs in Association with CCT. TCT 2013 Scientific Committee and Faculty. San Francisco, CA. October 28-31, 2013. 2013 Research Annual Repor t // Central Office of Research Administration 47 Grantham, JA. My Most Difficult Retrograde Approach Case in 2013. TCT 2013 Scientific Committee and Faculty. San Francisco, CA. October 28-31, 2013. Grantham, JA. Chronic Total Occlusions: The Essential Technique of CTO Recanalization: Algorithm and Approach. TCT 2013 Scientific Committee and Faculty. San Francisco, CA. October 28-31, 2013. Grantham, JA. A Brief History of Antegrade Dissection Reentry (ADR): Techniques, Technologies and Current Best Practices. TCT 2013 Scientific Committee and Faculty. San Francisco, CA. October 28-31, 2013. Green P, Kirtane A, Genereux P, McAndrew T, Hueter I, Alu M, Arnold S, Beohar N, Rihal C, Mack M, Kapadia S, Mauer M, Williams M, Kodali S, Leon M,Cohen D. The Impact of Six-Minute Walk Test Performance on Outcomes After Transcatheter Aortic Valve Replacement: Insights from the PARTNER Trial. J Am Coll Cardiology 52nd Annual Scientific Sessions San Francisco, CA. March 9-11, 2013. Grodzinsky A, Arnold SV, Gosch K, Spertus JA, Parashar S, Maddox TM, Kosiborod M. Frequency of Angina after Acute Myocardial Infarction Among Patients with Nonobstructive Coronary Artery Disease. American Heart Association Scientific Sessions. Dallas, TX. November 16-20, 2013. Gukathasan N, Weisz G, Witzenbichler B, Kini A, Henry T, Sartori S, Baber U, Cohen D, Chieffo A, Hermiller J, Stuckey T, Shawl F, Moliterno D, Antoniucci D, Berger P, Waksman R. Frequency and Impact of Single versus Dual Antiplatelet Cessation on Adverse Cardiac Events: Results from the PARIS Registry. J Am Coll Cardiology 52nd Annual Scientific Sessions San Francisco, CA. March 9-11, 2013. Gupta A, Wang Y, Spertus J, Geda M, Lorenze N, D’Onofrio G, Lichtman J, Krumholz H. Sex-Specific Trends in Hospitalizations among Young Patients with Acute Myocardial Infarction in United States, 2001-2010. American College of Cardiology Scientific Sessions San Francisco, CA. March 9-11, 2013. Gupta S. Anticoagulation in Atrial Fibrillation: A Shifting Paradigm. Physician Continuing Education Seminar, Western Missouri Medical Center. Warrensburg, MO. June 20, 2013. Gupta S. A Novel Approach to Screening for Sleep Apnea Utilizing Data from Implantable Cardioverter Defibrillators - Poster. Heart Rhythm Society 34th Annual Scientific Sessions. Denver, CO. May 8-11, 2013. Gupta S. Two EP Case Presentations. Kansas City Electrophysiology Master Conference. Kansas City, MO. October 2013. 48 Hachamovitch R, Spertus J, Marwick T. Association Between Heart Failure Diagnosis, Left Ventricular Ejection Fraction and Measures of Patient-Assessed Quality of Life and Functional Status. American College of Cardiology Scientific Sessions San Francisco, CA. March 9-11, 2013. Harris W, Kennedy KF, Jones PG, Maddox TM, Spertus JA. Fish Oil Supplementation in Post-Myocardial Infarction Patients in the Triumph Study: Defining Characteristics and Relations with Two-year Mortality. American College of Cardiology Scientific Sessions San Francisco, CA. March 9-11, 2013. Hart AJ, Aksoy O, Blackstone E, Lytle B, Hachamovitch R, Griffin B. Role of Calcium Supplementation in Structural Valve Deterioration. American College of Cardiology Scientific Sessions San Francisco, CA. March 9-11, 2013. Hart AJ. Interventional Dilemmas. Geoffrey O. Hartzler MD Interventional Cardiology Symposium: Principles & Perspectives - State of the Art. Maui, Hawaii. July 15-19, 2013. Hawkins BM, Kennedy K, Aronow HD, Nguyen L, White CJ, Rosenfield K, Normand ST, Spertus JA, Yeh RW. Hospital Variation in Carotid Artery Stenting Outcomes: An NCDR® Analysis. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Huber KC. Left Atrial Appendage and Stroke. 43rd Annual Dr. Robert D. Conn Heart Conference Kansas City, MO. December 12, 2013. Jayaram N, Buchanan D, Gosch K, Jones PG, Tollefson JE, Spertus JA. Understanding the Protective Benefits of Marriage on Survival After Myocardial Infarction. American Heart Association Scientific Sessions. Dallas, TX. November 16-20, 2013. Jayaram N, Krumholz HM, Chaudhry SI, Mattera J, Tang F, Spertus JA. Impact of Telemonitoring on Health Status in Patients with Heart Failure. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Jayaram N, Spertus J, Tang F, Chan P. Hospital Variation in Survival for Pediatric In-Hospital Cardiac Arrest: A Report from Get with the Guidelines Resuscitation. American College of Cardiology Scientific Sessions San Francisco, CA. March 9-11, 2013. Jayaram N, Spertus JA, Tang F, Chan PS. Hospital Variation in Survival for Pediatric In-Hospital Cardiac Arrest: A Report from Get With the Guidelines - Resuscitation. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD, May 15-17, 2013. 2013 Research Annual Repor t // Central Office of Research Administration Jones P, Chan P, Gosch K, Li Y, Reid K, Tang F, Spertus J. The SAQ-7: A Short Version of the Seattle Angina Questionnaire. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Kosiborod M. Predicting Cardiovascular Risk in Diabetes - Are Emerging Markers Better than Lipids? American Diabetes Association Scientific Sessions Chicago, IL. June 23, 2013. Jones P, Gosch K, Li Y, K, Tang F, Chan P, Spertus J. The KCCQ-12: A Short Version of the Kansas City Cardiomyopathy Questionnaire. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Kosiborod M. Predicting Cardiovascular Risk in Diabetes - Are Emerging Markers Better than Lipids? American Association of Clinical Chemists Scientific Sessions. Houston, TX. July 30, 2013. Joseph S, Novak E, Arnold S, Platts A, Roman VD, Mann D, Spertus J. Validity and Reliability of the Kansas City Cardiomyopathy Questionnaire in Patients with Heart Failure and Preserved Ejection Fraction. American College of Cardiology Scientific Sessions. San Francisco, CA. March 9-11, 2013. Karrowni W, Li Y, Jones P, Cresci S, Abdallah M, Maddox T, Spertus J, Horwitz P. Prognostic Significance of Albuminuria in Diabetic and Non-Diabetic Patients with Recent Acute Myocardial Infarction. American College of Cardiology Scientific Sessions. San Francisco, CA. March 9-11, 2013. Kherada N, Sartori S, Vadde R, Bharathi P, Cohen D, Militerno D, Steg P, Henry T, Weisz G, Witzenbichler B, Colombo A, Mehran R. Predictors of Dual Antiplatelet Therapy Non-Adherence After PCI: One-Year Insights from the PARIS Registry. J Am Coll Cardiology 52nd Annual Scientific Sessions San Francisco, CA. March 9-11, 2013. Kodali SK, Williams M, Humphries K, Cohen D, Nkomo V, Weissman N, Thourani V, Svensson L, Tuzcu EM, McAndrew TC, Leon MB, Miller DC, Kirtain A. Sex-Specific Differences in Late Mortality After Transcatheter AVR in the PARTNER Trial. J Am Coll Caridology 52nd Annual Scientific Sessions San Francisco, CA. March 9-11, 2013. Kolm P, Zhang Z, Spertus J, Weintraub WS. Multilevel Analysis of Clinical Trial Data: Is It Necessary? Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Kosiborod M. Evaluation of Ranolazine in Patients with Type 2 Diabetes Mellitus and Chronic Stable Angina - Results from the TERISA Randomized Clinical Trial. American College of Cardiology Scientific Sessions - Late Breaking Clinical Trials Session. San Francisco, CA. March 8, 2013. Kosiborod M. Management of a Diabetic Patient with Acute Coronary Syndrome. American Association of Clinical Endocrinologists. Phoenix, AZ. May 3, 2013. Kosiborod M. Diabetes and Heart Disease. American Association of Clinical Endocrinologists Heartland Chapter. Kansas City, MO. August 24, 2013. Kosiborod M. Personalized Management for Patients with SIHD & Type 2 Diabetes: Examining the Clinical Evidence. Cardiometabolic Health Congress. Boston, MA. October 3, 2013. Kosiborod M. What is Quality of Care in Patients with Diabetes Hospitalized with Cardiovascular Illness? Chicago, IL. October 12, 2013. Kosiborod M. Continuous Glucose Monitoring Technology in the Cardiac Patient: Does It Have a Role? American Heart Association Scientific Sessions - PRIDE (Planning Research in Inpatient Diabetes) Inaugural Meeting. Dallas, TX. November 17, 2013. Kosiborod M. Why is My Diabetic Patient so High Risk for Coronary Artery Disease? 43rd Annual Dr. Robert D. Conn Heart Conference Kansas City, MO. December 13, 2013. Kramer DB, Kennedy K, Noseworthy P, Buxton A, Josephson M, Normand SL, Spertus J, Zimetbaum P, Reynolds M, Mitchell SL. Characteristics and Outcomes of Patients Receiving New and Replacement Implantable CardioverterDefibrillators: Results from the NCDR. American College of Cardiology Scientific Sessions San Francisco, CA. March 9-11, 2013. Kugelmass A, Brown PP, Reynolds M, Cohen DJ, Culler SD, Simon AW. Concomitant Contrast Dependent Procedures are Predictors of Increasing PCI Associated Renal Complications Among Medicare Beneficiaries. Circ Cardiovasc Qual Outcomes 2013 May;6:A106. Baltimore, MD. May 15-17, 2013. Kugelmass A, Brown PP, Reynolds M, Cohen DJ, Culler SD, Simon AW. Trends in Renal Complication Rates among Medicare Beneficiaries Undergoing PCI: Fiscal Years 2009 through 2011. Circ Cardiovasc Qual Outcomes 2013 May;6:A49. Baltimore, MD. May 15-17, 2013. 2013 Research Annual Repor t // Central Office of Research Administration 49 Kulkarni VT, Ross JS, Wang Y, Nallamothu BK, Spertus JA, Normand ST, Masoudi FA, Krumholz HM. Regional Cardiologist Density and 30-day and 1-year Mortality in Acute Myocardial Infarction and Heart Failure. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Kureshi F, Arnold SV, Li Y, Masoudi FA, Jones PG, Cresci S, Maddox TM, Ho M, Spertus JA. Development of a 30-day Angina Risk Standardization Model Following an Acute Myocardial Infarction. American Heart Association Scientific Sessions. Dallas, TX. November 1620, 2013. Kureshi F, Jones P, Buchanan D, Abdallah M, Spertus J. Variability in Patient Misperceptions on the Indication and Benefits of PCI in Stable Coronary Artery Disease Within and Across Centers. American College of Cardiology 52nd Annual Scientific Sessions. San Francisco, CA. March 9-11, 2013. Kureshi F, Jones P, Buchanan D, Abdallah M, Spertus J. Variability in Patient Misperceptions on the Indication and Benefits of PCI in Stable Coronary Artery Disease Within and Across Centers. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Kureshi F, Jones PG, Abdallah M, Buchanan DM, Spertus JA. Chronic Stable Angina Patient Misperceptions on the Indication and Benefits of Percutaneous Coronary Intervention: A Look at the Variation Among Centers and Providers. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Laster S. Carotid Disease Beyond Carotid Duplex Imaging. 43rd Annual Dr. Robert D. Conn Heart Conference Kansas City, MO. December 12, 2013. Lindsey J. Superficial Venous Insufficiency: Diagnosis and Treatment Hutchinson Regional Medical Center Hutchinson, KS. March 13, 2013. Lindsey J. Anti-Platelets/Anticoagulants: Why We Use Them and When we can Stop Them. 43rd Annual Dr. Robert D. Conn Heart Conference Kansas City, MO. December 13, 2013. Main M. Common Contrast Artifacts and How to Deal with Them. 23rd Annual Echo Conference Big Island, Hawaii. January 21-25, 2013. Main M. Health Care Reform: How Can We Survive in this Brave New World? 23rd Annual Echo Conference Big Island, Hawaii. January 21-25, 2013. Main M. TAVR Imaging Cases: Complications to Avoid. Post Implant Aortic Insufficiency - Valve in Valve. 62nd Annual American College of Cardiology Scientific Sessions San Francisco, CA. March 11, 2013. Main M. How to Apply Contrast in Echo Lab. 24th Annual American Society of Echocardiography Scientific Sessions. Minneapolis, MN. June 29-July 2, 2013. Main M. Integrating a Private Practice into a Hospital Setting. 24th Annual American Society of Echocardiography Scientific Sessions. Minneapolis, MN. June 29-July 2, 2013. Marso S. Transradial PCI is Associated with Lower Cost in Medicare Fee-for-Service Beneficiaries Following Elective PCI. Oral Presentation at the American College of Cardiology Scientific Sessions 2013. San Francisco, CA. March 10, 2013. Marso S. Overreliance on Stress Testing. American College of Cardiology Scientific Sessions. San Francisco, CA. March 9, 2013. Marso S. Management of the Inappropriate Interventionalist: Who is Responsible and What is the Future of AUC? The Society for Cardiovascular Angiography and Interventions Scientific Sessions. Orlando, FL. May 9, 2013. Marso S. These AUC Are Just Wrong! Geoffrey O. Hartzler MD Interventional Cardiology Symposium; Inaugural Principles & Perspectives in Interventional Cardiology - State of the Art. Maui, Hawaii. July 15, 2013. Marso S. Clinical Data from First in Man to SYMPLICITY Trials. Geoffrey O. Hartzler MD Interventional Cardiology Symposium; Inaugural Principles & Perspectives in Interventional Cardiology - State of the Art. Maui, Hawaii. July 16, 2013. Main M. Patent Foramen Ovale (PFO) and Stroke. 43rd Annual Dr. Robert D. Conn Heart Conference Kansas City, MO. December 12, 2013. Marso S. Low Cost of Transradial Access. Geoffrey O. Hartzler MD Interventional Cardiology Symposium; Inaugural Principles & Perspectives in Interventional Cardiology - State of the Art. Maui, Hawaii. July 18, 2013. Main M. Use of Contrast to Improve Quantification of Ventricular Function. 23rd Annual Echo Conference Big Island, Hawaii. January 21-25, 2013. Marso S. Metabolic Effects of Renal Denervation. American Heart Association Scientific Sessions. Dallas, TX. November 17, 2013. Main M. Integration of Contrast in Your Lab: Safety, Consent, Flow. 23rd Annual Echo Conference Big Island, Hawaii. January 21-25, 2013. 50 2013 Research Annual Repor t // Central Office of Research Administration Marso S. What Have We Learned in the Past Year About the Economics of Transradial Procedure? American Heart Association Scientific Sessions. Dallas, TX. November 20, 2013. Qian F, Parzynski CS, Chaudhry SI, Spertus JA, Krumholz HM. Racial Differences in Heart Failure Outcomes. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Marso S. Patient Selection for Direct Thrombin Inhibitors During PCI. Scripps Clinic’s 24th Annual Cardiovascular Interventions Conference. La Jolla, CA. October 4, 2013. Ramza B, Milasinovic G, Quartieri F, Vieau S, Li S, Compton SJ. Real-World Experience with Pacemakers Designed for Safe MRI Use: SureScan Post-Approval Study. Poster Presentation, Heart Rhythm Society 34th Annual Scientific Sessions Denver, CO. May 8-11 2013. Marso SP, Poulter NR, Nissen SE, Zinman B, Pocock S, Bergenstal RM, Ravn LS, Moses AC, Buse J. Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome and Results (LEADER) Trial Design and Methods. 49th European Association for the Study of Diabetes. Barcelona, Spain. September 23, 2013. Marso SP. Next Generation Devices and Procedural Details. Geoffrey O. Hartzler MD Interventional Cardiology Symposium; Inaugural Principles & Perspectives in Interventional Cardiology - State of the Art. Maui, Hawaii. July 16, 2013. Martin SS, Joshi PH, Blaha MJ, Kulkarni KR, Khokhar A, Maddox TM, Havranek EP, Toth PP, Li Y, Spertus JA, Jones SR. Remnant Lipoprotein Cholesterol and Mortality after Acute Myocardial Infarction: The TRIUMPH Prospective Multi-Center Registry. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Nkonde-Price C, Dreyer RP, Hammond G, Strait KM, Zhou S, Lorenze NP, Lichtman JH, D’Onofrio G, Groeneveld PW, Spertus JA, Krumholz HM. Striking Variation in Clinical Profiles of Young Black and White Women with Acute Myocardial Infarction: The VIRGO Study. American Heart Association Scientific Sessions. Dallas, TX. November 16-20, 2013. O’Keefe JH. You Are What You Drink: Effects of Beverages on Cardiovascular Health and Life Expectancy. 43rd Annual Dr. Robert D. Conn Heart Conference Kansas City, MO. December 12, 2013. Parashar S, Jones PG, Kontos MC, Vaccarino V, Lichtman JH, Spertus JA. Biomarker Profile of Younger Women After Acute Myocardial Infarction. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Paul SK, Marso SP, Maggs D, Klein K, Best JH. Longterm Cardiovascular Outcomes with Exenatide Twice Daily Compared to Insulin: A Retrospective Observational Study. American Diabetes Association Scientific Sessions Chicago, IL. June 23, 2013. Rutherford BD. History of Angioplasty: Evolution of an Art. 43rd Annual Dr. Robert D. Conn Heart Conference Kansas City, MO. December 13, 2013. Saeed I. When Echo is Not Enough: The Incremental Value of Cardiac Magnetic Resonance Imaging. Greater KC Echo Society Annual Symposium Kansas City, MO. April 13-14, 2013. Saeed I. Where Does Cardiac Magnetic Resonance Fit? International Nuclear Cardiology & Cardiac CT Congress (ICNC) 11th Scientific Sessions Berlin, Germany. May 6, 2013. Saeed I. Utility of Cardiac Magnetic Resonance in Guiding Patient Management. International Nuclear Cardiology & Cardiac CT Congress (ICNC) 11th Scientific Sessions Berlin, Germany. May 7, 2013. Saeed I. Advances in Echo. International Nuclear Cardiology & Cardiac CT Congress (ICNC) 11th Scientific Sessions Berlin, Germany. May 7, 2013. Saeed I. What Can MR Provide in Diagnosis of New Heart Failure, Update on Echo, MR Guiding Therapy. International Nuclear Cardiology & Cardiac CT Congress (ICNC) 11th Scientific Sessions Berlin, Germany. May 7, 2013. Saeed I. Multimodality Review of Cardiovascular Pathology. Missouri State Radiological Technologists Kansas City, MO. September 28, 2013. Saeed I. What Every General Cardiologist Should Know About Congenital Heart Disease. ACCMissouri Chapter’s 5th Annual Update in Cardiovascular Diseases. St. Louis, MO. October 5, 2013. Safley DM, Venkitachalam L, Kennedy K, Cohen D. Clinical Outcomes Following Glycoprotein 2b/3a Inhibition in PCI for Acute Coronary Syndrome: Insights from the NCDR. J Am Coll Cardiology 2013 Mar;61(10S):A475. San Francisco, CA. March 9-11, 2013. Safley DM. Stenting Improves Quality of Life for Patients with PAD. Vascular Interventional Advances Meeting (VIVA). Las Vegas, NV. October 8, 2013. 2013 Research Annual Repor t // Central Office of Research Administration 51 Salisbury AC, Spertus J, Reid K, Amin A, Gosch K, Kosiborod M. Variation in Blood Transfusion Practices at the Time of Acute Myocardial Infarction: An Analysis of Consecutive Patients from 48 U.S. Hospitals. American College of Cardiology Scientific Sessions. San Francisco, CA. March 9-11, 2013. Smolderen K, Elshof J, van Zitteren M, Spertus JA, Denollet J, Nooren M, Heyligers J, Vriens PW. Lipid Control in Patients with New Symptoms of Peripheral Arterial Disease Evaluated at Vascular Specialty Clinics. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Sauser K, Spertus JA, Pierchala L, Pang PS. Use of the Kansas City Cardiomyopathy Questionnaire to Assess Acute Heart Failure Patients. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Spatz ES, Matlock DD, Li Y, Spertus JA, Krumholz HM. Medical Decision-Making: Preferences and Practices in the Year Following Acute Myocardial Infarction. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Shi R, Wang Y, Lichtman JH, Charmarajan K, Masoudi FA, Dodson JA, Chen J, Chaurhry SI, Spertus JA, Nallamothu BK, Krumholz HM. National and Regional Trends in Hospitalizations for Hemorrhagic Stroke after Acute Myocardial Infarction in the United States: 19992010. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Spertus JA. Quality Improvement and Evidence Implementation Research. 5th Annual Methods Seminar in Outcomes Research: Patient Safety. University of Alabama, Birmingham, AL. February 26, 2013. Shore S, Maddox TM, Bradley SM, Li Y, Spertus JA, Ho M. Utilization of Guideline-Concordant Therapies in Longitudinal Care after Myocardial Infarction as a Function of Patient Risk. American Heart Association Scientific Sessions. Dallas, TX. November 16-20, 2013. Skolnick D. Cardiology: Everyday Issues in Office Practice. Primary Care Physician Meeting. Big Island, Hawaii. October 21, 2013. Skolnick D. Interpreting ECGs, from Easy to Hard. Primary Care Physician Meeting. Big Island, Hawaii. October 22, 2013. Skolnick D. Novel Anticoagulants: Which One Should I Use? Primary Care Physician Meeting. Big Island, Hawaii. October 23, 2013. Skolnick D. Heart Failure Cases: A Review of Common Etiologies and Treatments. Primary Care Physician Meeting. Big Island, Hawaii. October 23, 2013. Skolnick D. Stroke Prevention in Atrial Fibrillation Novel Anticoagulants. 43rd Annual Dr. Robert D. Conn Heart Conference Kansas City, MO. December 12, 2013. Smolderen K, Decker C, Garavalia B, Scott KM, Chhatriwalla EG, Nugent K, Daniel WC, Rivas-Gotz C, Mena C, Spatz E, Stilp E, Spertus JA. Listening to a Diversity of Patient Voices to Design a High Quality Peripheral Arterial Disease Registry Focusing on Patient-Centered Outcomes. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Spertus JA. How to Set Up an Acute Coronary Syndrome Performance Improvement Program. Meet the Experts Session at the American College of Cardiology Scientific Sessions. San Francisco, CA. March 9, 2013. Spertus JA. Should we Monitor Patients with Quality of Life Instruments? How Should We Monitor the Patient with Heart Failure? American College of Cardiology Scientific Sessions Symposium. San Francisco, CA. March 10, 2013. Spertus JA. Quality of Life - What about the Patient? Quality of Life and Patient Satisfaction in a Clinical Focus Entitled Management Dilemmas in Chronic Coronary Heart Disease. American Collegel of Cardiology Scientific Sessions. San Francisco, CA. March 10, 2013. Spertus JA. Implementation of Comparative Effectiveness Research. University of Washington Comparative Effectiveness Conference. St. Louis, MO. April 18, 2013. Spertus JA. Overview of Personalized Medicine in NCDR: Opportunities to Improve the Safety and Quality of PCI. American College of Cardiology CQC/ NCDR Meeting. Washington, DC. April 28, 2013. Spertus JA. Comparative Effectiveness Research to Practice. Translating Joint ACC CQC/NCDR Meeting Heart House. Washington, DC. May 29, 2013. Spertus JA. Personalized Medicine to Improve the Health and Outcomes of Women in Cardiovascular Disease FDA Health of Women Conference. Silver Springs, MD. June 24, 2013. Spertus JA. Personalizing Care for PCI. Hongzhou Interventional Conference. Hongzhou, China. August 4, 2013. 52 2013 Research Annual Repor t // Central Office of Research Administration Spertus JA. Outcomes Research as a Foundation for Personalized Medicine. University of Tilberg Vascular Rounds. Tilberg, The Netherlands. September 4, 2013. Spertus JA. Delivering Personalized Medicine Today. Plenary Speaker, University Health Consortium Cardiovascular Conference, Ohio State University. Columbus, OH. September 12, 2013. Spertus JA. Quantifying Quality of Life in Stable Ischemic Heart Disease. Transcatheter Cardiovascular Therapeutics Conference. San Francisco, CA. October 28, 2013. Spertus JA. Benefits of Revascularization in Improving QOL in SIHD: Metrics, Magnitude and Patient Selection. Transcatheter Cardiovascular Therapeutics Conference. San Francisco, CA. October 29, 2013. Spertus JA. Defining the Optimal Role of AUC in Your Cath Lab. Transcatheter Cardiovascular Therapeutics Conference. San Francisco, CA. October 30, 2013. Spertus JA. What Really Matters: Integrating Hard Endpoints, Quality of Life and Patient Preferences. Transcatheter Cardiovascular Therapeutics Conference. San Francisco, CA. October 30, 2013. Spertus JA. Plenary Presentation on New Paradigms and Opportunities in Research - Determining What Matters to Patients - Using Patient Reported Outcomes. American Heart Association Scientific Sessions. Dallas, TX. November 16-20, 2013. Spertus JA. Young Investigators Forum - My Grant Just Got Rejected!! Now What?!? American Heart Association Scientific Sessions. Dallas, TX. November 1620, 2013. Spertus JA. Determining What Matters to Patients: Research Using Patient Centered Outcomes. American Heart Association Scientific Sessions. Dallas, TX. November 16-20, 2013. Spertus JA. Guidelines, Performance Measures and the Appropriate Use Criteria. 43rd Annual Dr. Robert D. Conn The Heart Conference. Kansas City, MO. December 12, 2013. Spertus JA. Personalized Medicine - Challenges and Opportunities to Improve Care. University of London Cardiovascular Grand Rounds. London, England. December 16, 2013. Stevens TL. Your Cardiovascular Health. Case Management Society of America. Overland Park, KS. May 8, 2013. Stevens TL. Unique Aspects of Women’s Cardiovascular Health. 6th Annual International Cardiac Symposium. Cayman Islands Medical & Dental Society. Cayman Islands. March 14, 2013. Stevens TL. Promoting Cardiovascular Health. Cayman Radio. Cayman Islands. March 14, 2013. Thomas MP, Parzynski C, Curtis J, Seth M, Nallamothu BK, Chan PS, Spertus JA, Patel MR, Bradley S, Burm HS. Geographic Regions with Low PCI Utilization Perform More Appropriate Percutaneous Coronary Interventions American Heart Association Scientific Sessions. Dallas, TX. November 16-20, 2013. Thompson RC, Allam AH, Lombardi GP, Wann LS, Sutherland ML, Sutherland JD, Soliman MA, Frohlich B, Mininberg DT, Monge JM, Vallodolid CM, Cox SL, Abd el-Maksoud G, Badr I, Miyamoto MI, El-Halim Nur ElDin A, Narula J, Finch CE, Thomas GS. Atherosclerosis Across 4000 Years of Human History: The Horus Study of Four Ancient Populations. American College of Cardiology Scientific Sessions. San Francisco, CA. March 10, 2013. Thompson RC. The Business of mIBG Imaging, Looking Back: The Horus Study of Four Ancient Populations. 18th Annual American Society of Nuclear Cardiology. Chicago, IL. September 26-29, 2013. Spertus JA. Engaging the Patient in Decision Making in Acute Stroke Care. American Heart Association Scientific Sessions. Dallas, TX. November 16-20, 2013. Thompson RC. IMPACT Radiological Mummy Database. Digging into Data Challenge Showcase in Conjunction with the World Social Sciences Forum. Montreal, Canada. October 12, 2013. Spertus JA. Using Outcomes Research and Personalized Medicine to Improve the Quality of Care. University of Alberta Cardiovascular Grand Rounds. Alberta, Canada. December 11, 2013. Thompson RC. Atherosclerosis: A Modern Malady or Ancient Illness? 25 Annual Cardiovascular Disease Symposium. Toledo, OH. December 6, 2013. Spertus JA. Interpreting Patient-Reported Outcomes - An Update on the State of the Art. University of Alberta Research Conference. Alberta, Canada. December 11, 2013. 2013 Research Annual Repor t // Central Office of Research Administration 53 Vigen R, Ho PM, Jones PG, Spertus JA, Arnold SV, Bradley SM. Hospital-Level Variation in One-Year Mortality and Angina Following Myocardial Infarction is Not Explained by In-Hospital Quality of Care in the TRIUMPH Registry. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Decker C, Spertus J, Cheng E, Gialde E, Chhatriwalla E, Summers D, Ayad, M, Saver J, Rymer. Stroke Survivors and Family Perspectives of Risk/Benefit: Developing Resolve (Rapid Evaluation For Stroke Outcomes using Lytics in Vascular Event. International Stroke Conference Nursing Symposium, Honolulu, HA, February 6. 2013. Wasfy JH, Strom JB, Rosenfield K, Zai A, Luttrell JM, Pomerantsev E, Spertus JA, Mauri L, Normand ST, Yeh RW. Causes of 30-day Readmission Rates after Percutaneous Coronary Intervention - Lessons from Direct Chart Review. Quality of Care & Outcomes Research Scientific Sessions. Baltimore, MD. May 15-17, 2013. Decker C, Spertus J, Rymer M, Summers D, Gialde E, Chhatiwalla E. St. Luke’s Hospital, Saver J, UCLA. Emergency Care/Systems. 2013 International Stroke Conference, Honolulu, Hawaii, February 6, 2013. Wasfy JH, Strom JB, Wimmer NJ, Zai A, Luttrell J, Spertus JA, Normand ST, Mauri L, Yeh RW. Preventability of 30day Readmission after PCI. American Heart Association Scientific Sessions. Dallas, TX. November 16-20, 2013. Zhang LQ, Cheranova D, Chaudhardy S, Dai H, Huang P, Grigoryev D, Heruth D, Li Y, Jones PG, Buchanan D, Spertus JA, Ye SQ. A New Genetic Biomarker for Coronary Artery Disease: Nicotinamide Phosphoribosyltransferase. American Heart Association Scientific Sessions. Dallas, TX. November 16-20, 2013. Zhang LQ, Cheranova D, Chaudhardy S, Dai H, Huang P, Grigoryev D, Heruth D, Li Y, Jones PG, Buchanan D, Spertus JA, Ye SQ. A New Genetic Biomarker for Coronary Artery Disease: Nicotinamide Phosphoribosyltransferase. American Heart Association Scientific Sessions. Dallas, TX. November 16-20, 2013. MIDWEST EAR INSTITUTE Cullen, R. Lewis, K. EAS: Candidate Assessment and Patient Management. Cochlear EAS Symposium, Las Vegas, NV, August 2013. NEUROSCIENCE INSTITUTE Akhtar N, Holloway W, Martin C, Rymer M, Akhtar E, Charkravarthy V. Use of Solitaire Retrieval Device in Wake-up Strokes: Saint Luke’s Neuroscience Institute Experience. American Society of Neuro Radiology, San Diego, CA, May, 20, 2013. Cheng E, Ayad M, Gialde E, Chhatriwalla E, Spertus J, Rymer M, Summers D, Saver J, Decker C. What Stroke Survivors and Families Need to Know For Decisionmaking During Acute Ischemic Stroke Care – A qualitative Research Study. International Stroke Conference Nursing Symposium, Honolulu, HA, February 6. 2013. 54 Dorssom J, Jones B, Taylor, K. Advanced Practice Registered Nurses Provide Cost-Effective, Quality Stroke Care. 2013 International Stroke Conference, Honolulu, Hawaii, February 6, 2013. King, S, Jenkins, J. EMS Collaboration to Improve Field Stroke Recognition. 2013 International Stroke Conference, Honolulu, Hawaii, February 6, 2013. King S, and Jenkins J. Hospital and EMS Collaborate to Improve Field Stroke Recognition. International Stroke Conference Nursing Symposium, Honolulu, HA, February 6, 2013. Rymer M. Mild Strokes: To Treat or Not To Treat. 2013 International Stroke Conference, Honolulu, Hawaii, February 6, 2013. Spertus J, Cheng E, -UCLA, Gialde E, Chhatriwalla E, Summers, D, Rymer M, -St. Luke’s Hospital. Stroke Survivors and Family Perspectives of Risk/Benefit: Developing RESOLVE (Rapid Evaluation for Stroke Outcomes Using Lytics in Vascular Event). 2013 International Stroke Conference, Honolulu, Hawaii, February 6, 2013. Summers D, Kansas City, MO, Matheson C, Stroudsberg, PA, Olson, DW, Durham, NC, Shepard, T, Richmond, VA. Outcome Management: Beyond Process Measures. International Stroke Conference Nursing Symposium, Honolulu, HA, February 6, 2013. Summers D. Comprehensive Overview of Nursing & Interdisciplinary Care of the Acute Stroke Patient. It’s Your Time To Peak: Translating Evidence and Excellence in Stroke Care conference. Shands University of Florida, Gainesville, FL May 2013. Summers D. Evidenced Based Nursing: Making a Difference in Stroke Patient Outcomes. First Health Moore Regional Hospital Pinehurst, NC, May 2013. Summers D. Evidenced Based Nursing: Making a Difference in Stroke Patient Outcomes. 7th Annual Stroke Conference. Integris Health. Oklahoma City, OK, February 20-13, 2013. 2013 Research Annual Repor t // Central Office of Research Administration Summers D. Pre-hospital and ED Acute Stroke Algorithm; Utilizing Advanced Imaging in Acute Stroke Treatment; NIHSS with Relation to Neuro Anatomy. First Annual Penrose Medical Center Stroke Conference. Colorado Springs, CO, November 2013. Summers D. Update on Ischemic Stroke Guidelines. Bethesda North Hospital Grand Rounds. Cincinnati, OH, July 2013. NURSING Cheng E, Ayad M, Gialde E, Chhatriwalla E, Spertus JA, Rymer M, Summers D, Saver J, Decker C. What Stroke Survivors and Families Need to Know for Decision-Making During Acute Ischemic Stroke Care: A Qualitative Research Study. American Heart Association/American Stroke Association International Stroke Conference, Honolulu, Hawaii, February 2013. Decker C, Chhatriwalla E, Garavalia B, Spertus JA, Chen E, Gialde E. Differing Perspectives Between Physicians, Patients and Caregivers on the Value of an Individualized Estimate of the Benefits Of Thrombolysis at the Time of Acute Ischemic Stroke: Designing the Resolve (Rapid Evaluation for Stroke Outcomes using Lytics in Vascular Event) Decision Aid. American Heart Association Quality of Care and Outcomes Research Conference, Washington, DC, May 2013. Decker C, Spertus JA, Cheng E, Gialde E, Chhatriwalla E, Summers D, Ayad M, Saver J, Rymer M. Stroke Survivors and Family Perspectives of Risk/Benefit: Developing RESOLVE (Rapid Evaluation for Stroke Outcomes Using Lytics in Vascular Event). American Heart Association/American Stroke Association International Stroke Conference, Honolulu, Hawaii, February 2013. Dorssom J, Jones B, Taylor K. Advanced Practice Registered Nurses Provide Cost-Effective, Quality Stroke Care. International Stroke Conference Nursing Symposium, Honolulu, Hawaii, February 2013. Hunt D, Fowler M, Wheeler T. Case Study: Intraventricular Nicardipine for the Treatment of Postpartum Cerebral Angiopathy. American Association of Neuroscience Nursing Conference, Charlotte North Carolina, March 2013 King S, and Jenkins J. Hospital and EMS Collaborate to Improve Field Stroke Recognition. International Stroke Conference Nursing Symposium, Honolulu, Hawaii, February 2013. Rao SC, Chhatriwalla AK, Kennedy KF, Decker C, Gialde E, Spertus JA, Marso SP. Pre-Procedural Estimate of Individualized Bleeding Risk Impacts Physicians’ Utilization of Bivalirudin during Percutaneous Coronary Intervention. American College of Cardiology Scientific Sessions, San Francisco, California, March 2013. Smolderen KG, Decker C, Garavalia G, Scott KM, Chhatriwalla EG, Nugent K, Daniel WC, Rivas-Gotz C, Mena C, Spatz E, Stilp E, Spertus JA. Listening to a Diversity of Patient Voices to Design a High-Quality Peripheral Arterial Disease Registry Focusing on Patient-Centered Outcomes. American Heart Association Quality of Care and Outcomes Research Conference, Washington, DC, May 2013. Summers D, Matheson C, Olson, DW, Shepard, T. Outcome Management: Beyond Process Measures. International Stroke Conference Nursing Symposium, Honolulu, Hawaii, February 2013. Summers D. Comprehensive Overview of Nursing & Interdisciplinary Care of the Acute Stroke Patient. Translating Evidence and Excellence in Stroke Care Conference, Gainesville, Florida, May 2013. Summers D. Evidenced Based Nursing: Making a Difference in Stroke Patient Outcomes. First Health Moore Regional Hospital, Pinehurst, North Carolina, May 2013. Summers D. Evidenced Based Nursing: Making a Difference in Stroke Patient Outcomes. 7th Annual Stroke Conference, Oklahoma City, Oklahoma, February 2013. Summers D. Pre-hospital and ED Acute Stroke Algorithm; Utilizing Advanced Imaging in Acute Stroke Treatment; NIHSS with Relation to Neuro Anatomy. First Annual Penrose Medical Center Stroke Conference, Colorado Springs, Colorado, November 2013. Summers D. Update on Ischemic Stroke Guidelines. Bethesda North Hospital Grand Rounds, Cincinnati, Ohio, July 2013. PHARMACY Addington L, Oliver K, Patel R, Wilson J. Medication Evaluation Utilization of Insulin. American Society of Health-System Pharmacists Midyear Clinical Meeting, Orlando, Florida, December 2013. Bennett N. Residencies. Student Forum, Student Society of Health-System Pharmacists, Drake University, Des Moines, Iowa, April 2013. 2013 Research Annual Repor t // Central Office of Research Administration 55 Burton S, Galen K. Evaluation of the Effect of Pharmacist Education on Acute Myocardial Infarction Readmission Rates. Midwest Pharmacy Resident’s Conference, Omaha, Nebraska, May 2013. Little J. Real World Implications for Pharmacy Practice Model Change. Student Society of HealthSystem Pharmacists, Creighton University School of Pharmacy, Omaha, Nebraska, November 2013. Burton S, Galen K, Blunck K. Evaluation of the Effect of Pharmacist Education on Acute Myocardial Infarction Readmission Rates. Missouri Society of Health-System Pharmacists Annual Meeting, St. Louis, Missouri, April 2013. Little J. Conflict Resolution for New Practitioners. American Society of Health-System Pharmacists Midyear Clinical Meeting, Orlando, Florida, December 2013. Coleman A, Blunck K, Hayes C. Tolvaptan Use at a Tertiary Medical Center: Evaluating Appropriate Use, Safety, Efficacy and Cost. American Society of Health-System Pharmacists Midyear Clinical Meeting, Orlando, Florida, December 2013. Douglass L, Repp K, Lamar J, Woods M. Hypoglycemia in Patients Admitted on Home Antidiabetic Regimen. American Society of Health-System Pharmacists Midyear Clinical Meeting, Orlando, Florida, December 2013. Eklund J, Abi B, Bliss K, Repp K, Woods M. Effect of Adherence to Weight-Based Heparin Protocol on Achieving Therapeutic Anti-Xa Levels. American Society of Health-System Pharmacists Midyear Clinical Meeting, Orlando, Florida, December 2013. Huedepohl E, Woods M. Impact of Individualized Feedback on Medication Barcode Scan Rates. Missouri Society of Health-System Pharmacists Annual Meeting, St. Louis, Missouri, April 2013. Huedepohl E. Impact of Individualized Feedback on Medication Barcode Scan Rates. Midwest Pharmacy Resident’s Conference, Omaha, Nebraska, May 2014. Huninghake C, Blunck J, Milligan B, Woods M. Evaluation of Four-Factor Prothrombin Complex Concentrate in the Management of Warfarin-related Intracranial Hemorrhage. American Society of HealthSystem Pharmacists Midyear Clinical Meeting, Orlando, Florida, December 2013. Kelley P. Impact of Procalcitonin-Guided Antibiotic Therapy in Pneumonia and COPD Exacerbations in an Academic Community Hospital Setting. Midwest Pharmacy Resident’s Conference, Omaha, Nebraska, May 2013. Kelley P, Bennett N. Impact of Procalcitonin-Guided Antibiotic Therapy in Pneumonia and COPD Exacerbations in an Academic Community Hospital Setting. Missouri Society of Health-System Pharmacists Annual Meeting, St. Louis, Missouri, April 2013. 56 Martin K, Massey L, Mebel E, Ortega M. Smooth Transitions: Aligning Expectations of the First 90 Days. American Society of Health-System Pharmacists Midyear Clinical Meeting, Orlando, Florida, December 2013. McLouth E, Schnabel L. Evaluating a Maximum Osmolarity of 1100 mOsm/L for Extravasation in Neonates Receiving Total Parenteral Nutrition – A Retrospective Chart Review. Missouri Society of Health-System Pharmacists Annual Meeting, St. Louis, Missouri, April 2013. Miller B. Effects of Order Set Use on the Treatment of Clostridium difficile: A Best Practice Assessment. Midwest Pharmacy Resident’s Conference, Omaha, Nebraska, May 2013. Miller B, Berry T, Bennett N. Effects of Order Set Use on the Treatment of Clostridium difficile: A Best Practice Assessment. Kansas Council of Health-System Pharmacists Annual Meeting, Wichita, Kansas, April 2013. Nguyen V, Bennett N, Day K, House J, Woods M. Analysis of Subjective Procalcitonin Use in a Tertiary Healthcare System. American Society of Health-System Pharmacists Midyear Clinical Meeting, Orlando, Florida, December 2013. Nguyen T, Woods M, Bennett N. Evaluation of Antimicrobial Utilization on Bacterial Susceptibility Patterns Within Saint Luke’s Health System. American Society of Health-System Pharmacists Midyear Clinical Meeting, Orlando, Florida, December 2013. O’Dell K, Anderson R, Ploetz J. Utilization of Prophylactic Enoxaparin Before and After Modification of the VenousThromboembolism (VTE) Order Set and the Plausibility of Pharmacist Driven VTE Discontinuation Criteria. Missouri Society of Health-System Pharmacists Annual Meeting, St. Louis, Missouri, April 2013. Pounders A. Evaluation of a Pharmacist-Driven Protocol for the Discontinuation of Inappropriate Stress Ulcer Prophylaxis. Midwest Pharmacy Resident’s Conference, Omaha, Nebraska, May 2013. 2013 Research Annual Repor t // Central Office of Research Administration Pounders A, Blunck J, Ploetz J. Evaluation of a Pharmacist-Driven Protocol for the Discontinuation of Inappropriate Stress Ulcer Prophylaxis. Missouri Society of Health-System Pharmacists Annual Meeting, St. Louis, Missouri, April 2013. Pummel S, Aldridge S. Evaluation of Intravenous Iron Sucrose Prescribing After the Implementation of a Mandatory Order Set Across a Four Hospital System. Kansas Council of Health-System Pharmacists Annual Meeting, Wichita, Kansas, April 2013. Pummel S. Evaluation of Intravenous Iron Sucrose Prescribing After the Implementation of a Mandatory Order Set Across a Four Hospital System. Midwest Pharmacy Residents Conference, Omaha, Nebraska, May 2013. Smith B, Bennett N. Improvement of Empiric Antibiotic Selection Through Annual Drug-Bug Mismatch Analysis. American Society of Health-System Pharmacists Midyear Clinical Meeting, Orlando, Florida, December 2013. RADIOLOGY Al Qaisi, Walker CM, Cox CW, Kanne JP, Chung JH. Role of Bronchoalveolar Lavage in the Diagnosis ofInterstitial Lung Diseases. Poster at AUR, April 2013. Andresen KJ. Genitourinary: Kidney, Case Based Imaging Review Course. American Roentgen Ray Society Annual Meeting, Washington DC, April 2013. Benson RE, Rosado-de-Christenson ML, MartinezJimenez S, Kunin JR, Watson K, Pettavel PP. Spectrum of Thoracic Neuroendocrine Proliferations and Neoplasms: Carcinoid, Carcinoid Tumorlets, DIPNECH, & Carcinoid Syndrome. Third World Congress of Thoracic Imaging, Seoul, South Korea, June 8-11, 2013. Bhatt M, Adler K, Borsa JJ, Cho K, Saucier N, Wible BC. Sacroplasty: “A Remedy for Pains in the Butt?” Radiological Society of North American 99th Scientific Assembly and Annual Meeting, Chicago, IL. December 2013. Certificate of Merit Award Borsa JJ. BRTO Lecture, Society of Abdominal Radiology Annual Meeting, Maui, HI, Feb 24 – March 1, 2013 Desouches S, Sanchez JL, Stull MA. Crystalline Disease: The Good, the Bad, the Ugly, and the Imposters. Association of University Radiologists 61st Annual Meeting. Los Angeles, CA, April 9 -12, 2013. Franquet T, Rosado-de-Christenson ML, Kanne JP, Marchiori E, Martínez-Jiménez S, Gimenez A. Hemorrhagic And Vascular Complications In Lung Infections: High-Resolution CT And Pathologic Findings. Radiological Society of North American 99th Scientific Assembly and Annual Meeting, Chicago, IL. November – December 2013. Magna Cum Laude Award Kunin J, Martinez-Jimenez S, Rosado-de-Christenson ML, Walker CM. High Resolution Computed Tomography Of Hemorrhagic Disorders. Radiological Society of North American 99th Scientific Assembly and Annual Meeting, Chicago, IL. December 2013. Lerner DJ, Wible BC, Gooden C, Pelletier S, Randall HB. A Novel Procedure For Managing Excluded Segmental Postoperative Bile Duct Leak. Americas Hepato-Pancreato-Biliary Association National Conference. Miami, FL. Feb 2013. Martínez-Jiménez S. Non-Surgical Extracardiac Vascular Shunts Of Thorax. Visiting Lecturer, University of Virginia. Charlottesville, VA. 15 March 2013. Martínez-Jiménez S. Ascending Thoracic Aorta: Postoperative CT Evaluation. Visiting Lecturer, University of Virginia, Radiology - Grounds Rounds. Charlottesville, VA. 15 March 2013. Martínez-Jiménez S. Idiopathic Interstitial Pneumonia. Asociacion Colombiana de Radiologia Zonal Santander. 20 March 2013. Martinez-Jimenez S, Rosado-de-Christenson ML, Walker CM, Kunin JR. Thoracic Metastases From Gynecological Neoplasms: How They Differ From Other Metastases, Specific Patterns Of Spread, And Pitfalls In Imaging Interpretation. Radiological Society of North American 98th Scientific Assembly and Annual Meeting, Chicago, IL. December 2013. Certificate of Merit Laude Award Peterson, PG Walker CM, Imanzadeh A, et al. Genetic mutations in NSCLC: Imaging patterns and implications. Electronic exhibit at ARRS, April 2013. Rosado de Christenson ML. Nodulo Pulmonar Solitario, Colegio Interamericano de Radiología, Cancún, Mexico, May 2013. Rosado de Christenson ML. Sarcoidosis, Colegio Interamericano de Radiología, Cancún, Mexico, May 2013. Rosado de Christenson ML. Tuberculosis, Colegio Interamericano de Radiología, Cancún, Mexico, May 2013. Rosado de Christenson ML. Enfermedades Pleurales No Neoplasicas, Colegio Interamericano de Radiología, Cancún, Mexico, May 2013. Rosado de Christenson ML. Enfermedades Pleurales Neoplasicas, Colegio Interamericano de Radiología, Cancún, Mexico, May 2013. 2013 Research Annual Repor t // Central Office of Research Administration 57 Rosado de Christenson ML, New Concepts and Imaging of Thymic Malignancies, World Congress of Thoracic Imaging, Third World Congress, Seoul, Korea, June, 2013. Rosado-de-Christenson ML, Martinez-Jimenez S, Walker CM, Kunin JR, Wible BC. Bronchial Arteries: Anatomy, Function, Hypertrophy and Interventions. Radiological Society of North American 99th Scientific Assembly and Annual Meeting, Chicago, IL. December 2013. Certificate of Merit Award Walker CM, Peterson PG, Abbott GF, et al. Imaging Findings of Pulmonary Infection: Classic Signs. Electronic exhibit at ARRS, April 2013. SURGERY Friedell ML. Transitioning from Medical School to Surgical Residency. Association of Program Directors in Surgery Panel Session, Moderator, Orlando, FL, April 26 2013. Friedell ML. Contemporary Management of Celiac Artery Compression Syndrome, Poster Presentation, Society for Clinical Vascular Surgery, Miami Beach, FL March 14-16 2013. Friedell, ML Perceptions of Graduating General Surgery Chief Residents: Are They Confident in Their Training? Southern Surgical Association, Podium Presentation, Hot Springs, VA, December 3, 2013. WOMEN AND CHILDREN Jodicke C, Singh P, Orth T, Bennett T, Mundy D, Maulik Dev. Correlation Between Prenatal and Postnatal Diagnosis of Congenital Heart Disease in a Quaternary Perinatal Center. Central Association of Obstetricians and Gynecologists Annual Meeting, Napa, CA October 16-19, 2013. Maulik, Dev. Managing Fetal Growth Restriction: Current Challenges, Advances in fetal functional Echocardiography-An Update. XI World Congress of Perinatal Medicine, Moscow, June 2013. Maulik, Dev. Current Approaches to Managing Premature Rupture of Membranes. XI World Congress of Perinatal Medicine, Moscow, June 2013. Maulik, Dev. Current Approaches to Managing Premature Rupture of Membranes. XI World Congress of Perinatal Medicine, Moscow, June 2013. Singh P, Jodicke C, Swanson T, Maulik Dev. Thoracic Ganglioneuromas Resulting in Hudrops Fetalis. Central Association of Obstetricians and Gynecologists Annual Meeting, Napa, CA October 16-19, 2013. 58 2013 Research Annual Repor t // Central Office of Research Administration Federally Funded Research Project Details Dr. Chan Project, pages 6 and 9 This project is funded 100 percent by research federal grant dollars and the total amount is $618,105. FREEDOM Trial, page 9 This project was funded 100 percent by research federal grant dollars and the total amount was $1,309,678. CORAL Trial, page 9 This project is funded 100 percent by research federal grant dollars and the total amount is $1,500,000. Dr. Spertus and Dr. Decker, Multivariable Risk Models, page 8 This project is funded 100 percent by research federal grant dollars and the total amount is $4,173,058. CIRT Project, page 10 This project is funded 100 percent by research federal grant dollars and the total amount is $765,000. Stanford University, Intra-arterial Stroke Treatment Project, page 12 This project is funded 100 percent by research federal grant dollars and the total amount is $65,386. The Johns Hopkins Medical Institutions, Hemorrhagic Stroke Study, page 12 This project is funded 100 percent by research federal grant dollars and the total amount is $21,572. ATTRACT Study, page 14 This project is funded 100 percent by research federal grant dollars and the total amount is $8,500. 2013 Research Annual Repor t // Central Office of Research Administration 59 2013 Board Medical Staff Research Committee Saint Luke’s Health System Committee Members: John Phillips, Chair Donald Campbell, M.D. David Cohen, M.D., Co-Chair Alan Forker, M.D. Rakesh Gaur, M.D. Kathy Harms, Ph.D. Dean L. Hubbard, Ph.D. David T. Hunt Darren Lovick, M.D. Timothy Pluard, M.D. David Powell Julie Quirin, CEO, Saint Luke’s Hospital Henry Randall, M.D. Marilyn Rymer, M.D. John Spertus, M.D. Karen Williams, Ph.D. John Yeast, M.D. Ex officio Members: Jacque Carpenter – Nursing Research Mike Coffman – Saint Luke’s Mid America Heart Institute Marilyn Horn – Institutional Review Board Krista Ludwikoski – Office of General Counsel Ellen McDowell – Central Office of Research Administration Anne Strassfeld – Office of General Counsel Thomas W. Wagstaff, Chairman, Saint Luke’s Health System Julie Weiss – Saint Luke’s Cancer Institute Veronica Koontz, Central Office of Research Administration Recorder of Minutes Contact us Central Office of Research Administration Saint Luke’s Hospital of Kansas City 4401 Wornall Road Kansas City, MO 64111 816-932-8161 saintlukeshealthsystem.org 2014-1022
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