Drug Delivery to the Lungs Conference - DDL25 10th – 12th December 2014 Edinburgh, UK Conference Themes Devices and Technology Regulatory and Emerging Markets Pharmaceutical Development The Pat Burnell Awards Respiratory Disease and Biology iology DDL - Shaping the next 25 years of nasal and pulmonary drug delivery PROGRAMME - DAY 1 WEDNESDAY 10TH DECEMBER 2014 SESSION 1 : DEVICES AND TECHNOLOGY 8:00am – 9:00am Registration 9.00am – 9.15am Welcome and Opening Remarks Gary Pitcairn, Conference Chair 9.15am - 9.45am Understanding the Interaction between Inhaled and Systemic Drugs using FRI: the Roflumilast Case 9.45am – 10.15am Jan de Backer, FluidDA nv Increasing Participation in and Improving Outcomes from Inhaler Training 10:15am – 11.15am Mark Sanders, Clement Clarke International Posters, Exhibition and Coffee 11.15am - 11.35am Do Fewer Dose Preparation Steps Improve the Usability of Multi-Dose DPIs? 11.35am – 11.55am Andreas Meliniotis, Vectura Delivery Devices Ltd Development of a Leak Detection System for Online Testing of Filled pMDI Devices 11.55am – 12.15pm Paul Miller, Cascade Technologies Ltd. Efficient Generation and Delivery of Dry Powder Aerosols During Low Flow Oxygen Administration 12.15pm – 2.00pm Michael Hindle, Virginia Commonwealth University Networking Buffet lunch 2 PROGRAMME - DAY 1 WEDNESDAY 10TH DECEMBER 2014 SESSION 2 : REGULATORY & EMERGING MARKETS 2.00pm – 2.45pm Annual DDL Lecture Inhaled Drug Formulation - The Past, Present and Future 2.45pm – 3.15pm Peter Stewart, Monash University Inhalation products in emerging markets: Is it really any easier? 3.15pm – 3.45pm David Howlett, PharmaDelivery Solutions Ltd The Rise of mhealth: How Technology is being used to Support Respiratory Patients 3.45pm – 4.45pm Georgina Fradley, Exco InTouch Manned Poster Session, Exhibition & Coffee 4.45pm – 5.05pm 5.05pm – 5.25pm 5.25pm – 5.45pm 5.45pm – 8.00pm Best Practices in Device Design for Orally and Nasally Inhaled Drug Products (OINDP) Rudi Mueller-Walz, Skyepharma AG, Switzerland On behalf of the European Pharmaceutical Aerosol Group (EPAG) Comparison of Europe’s TE/BE Guidelines for Orally Inhaled Products with FDA’s Weight of Evidence Approach Herbert Wachtel, Boehringer Ingelheim Pharma GmbH & Co. KG Evolution or Revolution to Address Patient, Healthcare Professional and Payer Inhalation Device Needs Richard Jenkins, 3M Healthcare Drug Delivery Systems Exhibitor Drinks Reception sponsored by Vectura PROGRAMME - DAY 2 THURSDAY 11TH DECEMBER 2014 SESSION 3 : PHARMACEUTICAL DEVELOPMENT 8:00 am – 9:00am Registration, Coffee and Poster Viewing 9.00am – 9.30am Deposition of Aerosols for Dissolution Experiments: How to Combine One with the Other? 9.30am – 9.50am Per Gerde, Karolinska Institutet Particle Engineering to Deliver Montelukast plus Heparin together to Treat Asthma 9.50am – 10.10am Fakhrul Ahsan, Texas Tech University Health Science Center SPAMS Analysis of Dry Powder Formulations Containing Indacaterol Maleate Bradley Morrical, Novartis Pharma AG – Development 10:10am – 11.10am Manned Poster Session, Exhibition & Coffee 11.10am – 11:30am Development of A Novel Laser Diffraction Method for Estimating Fine Particle Fraction of Adhesive Mixtures 11:30am – 12.00pm Patrik U Andersson, AstraZeneca Are Respiratory Cell Lines Proving Useful in Pharmaceutical Development? Alison Lansley, University of Brighton 12.00pm – 12.20pm 12.20pm – 2.30pm “WHAT ON EARTH” Four cyclists from Corsham, Wiltshire, captained by Bath and England rugby legend John Hall, race 3,000 miles across America in support of Asthma UK Networking Buffet lunch in The Lennox Suite h - PROGRAMME – DAY 2 THURSDAY 11TH DECEMBER 2014 SESSION 4 : THE PAT BURNELL AWARDS 2.30pm – 2.45pm An Investigation Into Delivery of Theophylline for Inhalation 2.45pm - 3.00pm Mary Goud, The University of Sydney The Impact of Drug Clearance on Duration of Action of Corticosteroids 3.00pm – 3.15pm Amir Hakim, Imperial College & Royal Brompton Hospital Inhaled Nanoparticles Develop a Complex Protein Corona of Biological Importance 3.15pm – 3.30pm Abhinav Kumar, King’s College London Screening and Optimization of Formulation and Process Parameters for the Manufacture of Inhalable Composite Particles by Spray-Drying 3.30pm – 3.45pm Cláudia Moura, Hovione SA An In Silico Laboratory for Patient-Specific Treatment of Asthma and COPD 3.45pm – 4.00pm Laura Nicolaou, Imperial College Resveratrol, A Novel Spray Dried Inhalation Powder for the Treatment of COPD and other Inflammatory Lung Diseases 4.00pm – 5.00pm Valentina Trotta, The University of Sydney Posters, Exhibition & Coffee SILVER JUBILEE CELEBRATION DINNER 6.00PM – MIDNIGHT 11TH DECEMBER CROMDALE HALL, EICC JOIN US TO CELEBRATE 25 YEARS OF DDL AND ENJOY SEASONAL FOOD, DRINK & GREAT ENTERTAINMENT PROGRAMME - DAY 3 FRIDAY 12TH DECEMBER 2014 SESSION 5 : RESPIRATORY DISEASE AND BIOLOGY 8.30am – 9:00am Registration, Coffee and Poster Viewing 9.00am – 9:30am Future Development in Respiratory Therapy 9.30am – 9.50am 9:50am – 10:20am 10:20am – 11.20am 11.20am – 11:50am Professor Neil Barnes, GlaxoSmithKline and The London School of Medicine and Dentistry The Fate of Albumin Nanoparticles in the ‘Black Box’ of the Lung - in vivo Investigations of Albumin Nanoparticle Partitioning into Lung Tissue, Broncheoalveolar Lavage Cells and Fluid 48 hours Post-Inhalation Arcadia Woods, King’s College London Development of Inhalation Medicine from Scientific Discovery to Clinical Proof-of-Concept for Treatment of Life-Threatening Pulmonary Odema Bernhard Fischer, APEPTICO Posters, Exhibition & Coffee The Development of a Novel 3D Airway Epithelial Cell Culture for use in High-Throughput Screening 11:50am – 12:10pm Henry Danahay, Novartis Institutes for BioMedical Research In vitro Assessment of Alveolar Macrophage Responses to Inhaled Particulate Medicines 12:10pm – 12:30pm Victoria Hutter, University of Hertfordshire Characterisation of Primary Air-Liquid Interface Culture of Nasal Epithelium for Nasal Drug Delivery 12.30pm – 1:00pm Hui Xin Ong, Southampton University Clinical Pharmacology and Physiology of Ageing: Implications for Drug Therapy 1:00pm – 1:15pm Stephen Jackson, King's College Hospital Closing Remarks Gary Pitcairn, Conference Chair