Dermatologic Surgery Kristy P. Gilbert, D.O. November 1, 2005 Introduction Derm surgery increasing in complexity Aesthetic and Laser procedures Plastic surgery – blepharoplasty, facelifts, liposuction Mohs micrographic surgery Increasing emphasis on patient safety, documentation, and accreditation. Basics: Pre-Op Evaluation Drug Allergies Meds: Coumadin, Plavix, ASA. Pacemaker? Defibrillator? MVP, Endocarditis, Prosthetics? Informed Consent, photographic consent, risks v. benefits and options must all be discussed & signed OTC and Herbals….. Past Medical History…. Past medical history Factors that will affect wound healing Prophylactic antibiotics Risks for scarring Risks for bleeding Factors that will affect wound healing Advanced age Nutritional status Diabetes Immunosuppressive drugs Smoking Critically ill patients, HIV Atherosclerosis, PVD Prophylactic Antibiotics Contaminated or “dirty” wounds benefit, not clean wounds Indications - ear, nose mouth, hand foot, axilla, genitalia (“dirty” areas) - Artificial Heart Valve - Artificial Joint Replacement < 6 months - Past history Endocarditis, Rheumatic Fever - Mitral Valve Prolapse WITH holosystolic murmur - Immunocompromised Antibiotic Prophylaxis: Standard: administer 1 hour pre-op and 6 hrs post-op Keflex: 1gm po pre-op, 500mg po post-op Dicloxicillin: 1gm po pre, 500mg po post Clindamycin 300mg po pre, 150mg po post Risks for scarring Location: upper chest, back, shoulders, extremities Personal hx scarring: i.e. keloids, hypertrophic scars Medications: isotretinoin in past 12 mo. Or Vitamin A or E use ASA/NSAID containing drugs There are about 160 of them Most are OTC Patients don’t think of these as drugs because they are not prescriptions. ASA/NSAID containing drugs Aspirin - Irreversibly acetylates platelet COX reducing PG and thromboxane A2 synthesis therefore platelets inhibited for their lifetime (7-10days) - For this reason, must be D/Ced 7-10 d pre-op NSAIDs - Reversibly inhibit COX therefore less clinical effect Other drugs affecting platelets Production - Myelosuppressive agents, ethanol, estrogens, thiazides Destruction - Abx: sulfathiazole; quinine, ASA, dig, methyldopa Function - ASA, dipyridamole, ethanol, heparin, NSAIDS, plavix, ticlopidine, herbal supplements Herbal Supplements that inhibit coagulation…. MOST COMMON: Fish Oils, Garlic, Gingko, Ginseng, Chinese Herbal/Green Teas, Vitamin E Alfalfa, Capsicum, Celery, Chamomile, Dong quai, Fenugreek, Feverfew, Ginger, Horseradish, Huang qui, Kava kava, Licorice, Passionflower, Red Clover. Dermatol Surg 28: June 2002, 449 Local Anesthesia Local anesthesia - - Ideal properties Rapid onset Long duration of action Lack of toxicity Water solubility Structure & function Aromatic portion= lipophilic= potency Amine= hydrophilic= solubility Intermediate chain- determines class: i.e. ester, amide AND most importantly- this determines route of excretion and metabolism MOA = blocks movement of Na+ influx across membrane thereby blocking depolarization Local Anesthesia Categories Esthers: - Procaine (novocaine) - Chloroprocaine (nesacaine) - Cocaine - Tetracaine - Benzocaine Amides -Lidocaine (xylocaine) - Mepivacaine (carbocaine) - Prilocaine (citanest) - Etidocaine(durantest) - Bupivicaine (marcaine) = the LONGEST acting - Nupercaine “I’m allergic to Novacaine” Pearl: It is OK to give Xylocaine to patients who had allergic reactions to Novocaine at the dentist’s office, Lidocaine is an Amide and Novocaine is an Ester. Pitfall: They may not know which medication they reacted to: use Bacteriostatic NS or diphenhydramine when in doubt. Esters>>>amides Local Anesthesia Pearl: fears of epinephrine induced necrosis at distal sites (nose, ears, penis, toes, fingertips) are largely unfounded. Pitfalls: patients with severe peripheral vascular disease, diabetic angiopathy and Raynaud’s phenomenon may be exceptions to the rule. Contraindications to epinephrine in anesthsia: -severe HTN, pheochromocytoma, HyperTH, severe vascular ds, bradycardia “ABSOLUTE” -pregnancy, MAO inhibitors, narrow angle glaucoma “RELATIVE” Local anesthesia - - Maximum dosage 1% lidocaine w/ epi 1:100,000 is 10mg of lidocaine per 1cc of mixture Adult= 7mg/kg = 500mg/ 70kg (50cc) Child = 3-4.5mg/kg 1% lidocaine w/o epi Adult= 4.5mg/kg = 300mg/70kg (30cc) Child= 1-2 mg/kg Insert needle at a 30 degree angle and slowly retract the needle as you inject the anesthetic. When the tissue blanches you are at the right level. Always best to try to avoid too many sticks, if your doing a larger area, each re-stick should be into an area that has already been anesthetised Pain Control Local Anesthesia: INJECT SLOWLY: Decreases pain more than warming or adding bicarbonate. Distraction techniques useful as well – pinching skin during injection, vibrating pen, etc. For pediatric patients, let them sit in the lobby with ELA-Max or EMLA under occlusion for 30 min.- 1 hr. Your eardrums will thank you. Surgical Cleansers Clean Procedures: Isopropyl alcohol weak antimicrobial most commonly used agent for shave biopsies Hydrogen peroxide no significant antiseptic properties not suitable for sterile procedures Surgical Cleansers: Sterile Betadine irritating to skin, residual color must dry completely to be antimicrobial absorbed by premature infants Chlorhexidine (Hibiclens) keratitis if it gets in the eyes Hexachlorophene (pHisoHex) not on women or children due to neurotoxicity and teratogenicity Common Procedures Shave Biopsy Punch Biopsy Excisional Biopsy Cryosurgery Shave biopsy Best suited to pedunculated, papular or otherwise elevated lesions but may be used for macular lesions. Simple Quick Satisfactory cosmetic result Adequate biopsy tissue for diagnosis Shave Biopsy Sterile #15 blade 4x4’s Drysol solution Sterile Q-tips Path container Gillette Blue Blade Razor cut in half, bends to follow contour Shave Biopsy - skin tension Shave Biopsy - flush w/ surface Endpoint is “pinpoint bleeding” Indicates you are at the level of the papillary dermis, minimal scarring Stay superficial for minimal scarring. Pink atrophic area has a full year to heal. Upper chest and back scars no matter what you do. Punch Biopsy Most common use is for skin biopsy Can excise small lesions Treats acne scars Hair transplantation May stretch skin perpendicular to skin tension lines to create elliptical defect and avoid “dog ears” Punch Biopsy Sterile OR clean procedure 3 or 4 mm punch is standard 4x4s, Drysol, Q-tips Needle driver, forceps Suture Path specimen bottle Punch Biopsy Twist punch tool until buried to the hub* *Caveat: Have a firm grasp of anatomy and skin thickness in the area you are punching before you punch it. Finger tendons, facial and neck structures. Punch biopsy KEY: do not crush tissue when removing it from the biopsy site. Crush artifact makes pathologic interpretation difficult to impossible. Some pull it out using the suture needle as this method is atraumatic. Punch Biopsy Use 5-0 or 6-0 nylon/Prolene on the face. 4-0 nylon/Prolene most other areas. Silk or vicryl usu. best for mucosal areas. 2 simple interrupted sutures. Out 7d face, 10d otw Hemostasis Chemical Electrical Physical Chemical Hemostasis Drysol Aluminum Chloride Quick, easy, cheap. Q-tip application. No odor or discoloration. Good for superficial biopsy - shave. Chemical Hemostasis Monsel’s solution. 20% ferric subsulfate. Cheap, easy to use. Risk of tattooing. Superficial only! Caustic, may destroy connective tissue if sutured into wound. Electrosurgery Electrosurgery- definitions Electrosurgery- passing high frequency alternating current (AC) thru the tissue Electrocautery- electrically heated metal element applied to tissue; transfers heat but does not transfer current thru tissue Electrolysis- low direct current (DC) passed thru tissue b/w 2 electrodes; chemical reaction occurs @ one electrode Diathermy- the process of heat production and tissue necrosis due to electrosurgery Monoterminal= one connection b/w device and pt. (i.e. electrodessication, electrofulgration, epilation, hyfercation) Biterminal= 2 contacts b/w device and pt. such as a ground plate (i.e. electrocoagulation, electrosection) Electrodessication/Electrofulguration Electrodessication – tip touches tissue Electrofulguration – 1-2mm separation between tip and tissue High voltage and low amperage limits depth of destruction Monoterminal current – no grounding required Electro-epilation Follicular destruction AKA Electrolysis Chemical reaction at electrode tip causes production of sodium hydroxide (lye) at the hair root – works without scarring. Takes 1 minute per follicle, very slow. Largely replaced by laser hair removal. Electrodessication LOW POWER: Facial telangiectasias Syringomas HIGH POWER: SK, Skin Tags, VV ED&C: BCC & SCC under 2 cm, 2-3 cycles Hemostasis during excisional surgery. Electrosection “Cutting Current”, Radio-Frequency Ablation Biterminal current produced by vacuum tube is similar in form to radiowaves Active electrode is cool Tissue disruption occurs in response to the wave at the point of contact. Minimal trauma, excellent hemostasis. “Custom” attachments: wire loops, balls, needles, scalpels. i.e. tx of rhynophyma THERMAL CAUTERY Heated metal results in tissue dessication, coagulation and necrosis. Safe to use in patients with pacemakers. Does not require a dry field. Electrosurgery and pacemakers Published debate Standard of care tends to be use of only electrocautery Most modern pacemakers operate in a demand mode, requiring sensing and output circuits which can be interupted by high frequency electrosurgery Curettage Round semi-sharp knife 0.5 to 10mm Does not easily cut through normal dermis and will not enter the dermis Best for soft friable lesions. Normal dermis feels gritty Cancer lesion + 2-3mm margin 2-3 cycles of ED&C ED&C Cryosurgery Easy, heals quickly, minimal complications Liquid nitrogen -195.6 degrees C Rapid freezing, slow thaw increases cellular damage Melanocytes are more sensitive to freezing than keratinocytes, may cause long lasting hyperpigmentation in darker complexions. Very commonly used in treatment of AKs, verruca, acrochordons, SKs, etc. Occasionally for superficial skin CAs Cryosurgery delivery systems Cotton swabs Cryospray Cryoprobe (allows deeper freeze w/o lateral damage) Cones Thermacouples Cryosurgery complications Pain HA Syncope Bleeding (2-3 wks p tx) Edema Abnormal scarring Nerve damage (digital neuropathy) Cartilage necrosis (ear) Abnormal pigmantation Alopecia Notching (eyelid, nasal tip, ear rim, VB of lip) Traumatic exfoliation ( if probe is not pre- chilled) Classic atrophic hypopigmented cryosurgery scars…… Excisions- margins - - BCC surgical margins Less than 2cm diameter- 4mm margins Greater than 2cm- MOHS SCC surgical margins 4mm margin diameter <2cm in low risk anatomical areas diameter <1cm in high risk area 6mm margin diameter >2cm in low risk areas diameter > 1cm in high risk areas Excisions- margins (cont’d) - - - Melanoma surgical margins In situ 0.5 cm border of clinically normal skin <2mm 1cm border of clinically normal skin >2mm 2-3cm margin Mask Area of Face Using felt tip pen mark a circle around lesion with recommended margins. Ellipse should be 3 times longer than circle around lesion. Try to position the final suture line within existing wrinkle lines/least tension. Always consider the anatomy! Branches of the facial nerve Facial Nerve Damage Temporal branch - Vulnerable as crosses mid zygoma lateral to eyebrow (don’t go below superficial fat) - forehead and eyebrow ptosis, may obstruct vision. Zygomatic branch – - Vulnerable as crosses buccal fat pad - impaired blinking, eyes cannot close tightly Buccal branch – - drooping corner of mouth, difficulty chewing Marginal Mandibular – - Vulnerable @ angle of mandible, inf to parotid - lower lip function, drooling Anatomy a lecture in itself- nerves, arteries, veins, glandular structures Excision: Instruments Needle Holders Forceps Skin hooks Scissors Webster Gillies BROWN ADSON FORCEPS – HEAVY TISSUES CASTROVIEJO FORCEPS – DELICATE TISSUES IDEAL FOR FLAPS, CUTTING THICK, LESS DELICATE TISSUE Absorbable Suture Gut (Chromic) fast absorbing for surface closure as tensile strength is lost in days (FTSG) Plain Polyglycolic acid (Dexon) Polyglactin 910 (Vicryl) Polydiaxone (PDS) Polytrimethylene carbonate (Maxon) Poliglecaprone 25 (Monocryl) Non Absorbable Suture Silk (good for oral mucosa) Nylon (Dermalon, Ethilon, Surgilon) Polypropylene (Prolene, Surgilene) Polyester (Dacron, Ethibond, Mersilene) Polybutester (Novafil) SIMPLE INTERRUPTED PRO: Good approximation of superficial tissues. CON: RR track scarring/time VERTICAL MATTRESS PRO: Enhances wound eversion and decreases scarring CON: Time consuming CORNER STITCH Helps avoid tip strangulation KEY: Be sure this is the last suture, not the first. Should be low tension. HORIZONTAL MATTRESS PRO: Good for high tension wounds CON: Tends to cut into/strangulate tissues and higher risk dehiscence or scarring. RUNNING RUNNING, LOCKED RUNNING HORIZONTAL MATTRESS DEEP SUTURES RUNNING SUBCUTANEOUS RUNNING SUBCUTICULAR Mohs Surgery Frederick Mohs 1930 Fixed Tissue Tromovitch 1970’s Frozen Tissue Pros: Cost effective outpatient surgery Precise control of tumor margins Allows smaller margins to be taken Cosmetically sensitive areas- H zone Not just for recurrent tumors anymore 95-99% cure rates for recurrent and previously untreated tumors Cons: Labor intensive and time consuming More expensive Mohs Excision of tumor in successive layers Rapid frozen sections of tissues made Microscopic evaluation of entire undersurface & margins of each layer Results recorded on diagram Mohs- indications - - Recurrent or persistent tumor Anatomic location Embryonic fusion planes Nasolabial folds Columella of nose Pre- auricular, post-auricular sulcus Conservation of tissue impt. eyelids, nose, lips, ears, genitalia Size >1cm on head >2cm on trunk & extremities Special considerations Very young/ old Immunocompromised Unusual tumors Pt or family anxiety Poorly defined borders Scar carcinoma - Major histo indications BCC subtypes Morpheaform Adenoid Superficial multifocal Perineural SCC subtypes Poorly differentiated Acantholytic Perineural Basosquamous Microcystic Adenexal DFSP Merkel cell Malignant fibrous histiocytoma Lentigo maligna Mohs Rowe et al reviewed literature since 1947 5 year recurrence rates primary BCC Mohs 1% Excision 10.1% C&D 7.7% XRT 8.7% Mohs Rowe et al cont’d Primary SCC 5 year recurrence rates Mohs 3.1% Excision 8.1% C&D 3.7% XRT 10% General Surgical Complications - Hematoma – usu 24-48 hrs post-op no evidence that ASA, NSAID or COUMADIN increases risk of hematoma Open and evacuate clot if necessary Gentle heat may facilitate reabsorption Bleeding Intraoperative control imperative Post-op: dressings, minimize post-op movement/activities ? d/c anticoagulants Infection – Main contamination period is peri-operative Pain, warmth, erythema, swelling, D/C, fever, chills, malaise Can culture, Irrigate, daily wound care, abx 7-10 days Dehiscence – from infection, trauma, poor surgical technique, excessive movement Necrosis – high tension in sutures or wound edges, poor flap design. Avoiding Surgical Complications Aseptic technique Meticulous hemostasis Wide undermining Good surgical planning A bit about flaps… Advancement flaps Primary movement is straight across the primary defect Essentially a large ellipse/ fusiform closure Types: O-H, O-T, V-Y, island pedicle Locations: -Unilateral- anywhere -Bilateral- forehead, eyebrow, upper lip, upper nose, chin Rotation flaps Primary movement is arc-like or rotary Tension distributed away from primary defect to secondary defect Tension decreased by increasing length Recommended locations: Scalp, forehead, chin, cheek Transposition flaps Movement of flap results in crossing intervening skin to reach defect Tension completely redirected from primary to secondary defect Creates larger secondary defect than other flaps Good for defects near free margin Cutaneous Laser Surgery Light Amplification by Stimulated Emission of Radiation Light limited to one WAVELENGTH CHROMOPHORES are substances that preferentially absorb one WAVELENGTH Examples: water, Hgb, melanin HEAT created = “Selective Thermolysis” Argon Laser Vascular and pigmented lesions 488 to 514 nm wavelength These are NOT the wavelengths specific to Hgb and melanin, therefore damage to surrounding tissue significant, possibly leading to scarring and hypopigmentation. Has fallen out of favor Flashlamp Pumped Pulsed Dye Port wine stains, telangiectasias 585 nm wavelength Low risk of scarring and pigment change Black/gray discoloration due to intravascular coagulation. Q switched Ruby Melanin and darkly pigmented tattoo pigments (black, blue, green) targets 694 nm wavelength Q-switching allows delivery of extremely high energy at pulses that last only nanoseconds Good for deep pigment, ie. Nevus of Ota Minimal scarring, transient hypopigmentation Neodynium:Yttrium-AluminumGarnet (Nd:YAG) 1064 wavelength Continuous mode – PWS, venous malformations Q-switched mode – black, blue tattoos Frequency doubled 532 - red tattoo, vascular, superficial pigmented KTP: Potassium Titanyl Phosphate 532 nm wavelength Vascular and superficial pigmented. Significant Hgb and melanin absorption Q-Switched Alexandrite 755 nm wavelength Absorbed by deep dark pigment ie., blue, black and green tatoo pigment IPL: Intense Pulsed Light Continuous spectrum 515 - 1200nm Extremely versatile Rosacea Telangiectasias Spotty discoloration Carbon Dioxide 10,600 nm wavelength, H2O chromophore Super-pulsed allows destruction of epidermis and papillary dermis while limiting deeper damage. Can actually see it tighten the collagen Excellent for photodamage, rhytids Lots of down time, side effects. Erbium:Yttrium-Al-Garnet Er:YAG 2940 nm wavelength Ablative, but with less thermal damage than the CO2 laser Ideal for treating very early photodamage (superficial), but will never tighten collagen as well as the CO2
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