1. No category

Aziz Daabash
Brett Michalk
Amanda Mogollon
Derek Nelson
What are Nanorobotics ?
How Nanorobots Work ?
Imagine going to the doctor to get
treatment for a persistent fever. Instead of
giving you a pill or a shot, the doctor refers
you to a special medical team which
implants a tiny robot into your
bloodstream. The robot detects the cause of
your fever, travels to the appropriate system
and provides a dose of medication directly
to the infected area.
Surprisingly, we're not that far off from seeing
devices like this actually used in medical
procedures.
Applications
•Treating arteriosclerosis
•Fighting cancer
•Helping the body clot
•Parasite Removal
•Gout "the disease of kings"
•Breaking up kidney stones
•Cleaning wounds
http://www.youtube.com/watch?v=P7zw9fvfBZI
Motivation
The Problem:
•Diabetes Patients must take small blood samples
many times a day (uncomfortable and inconvenient).
•The need for constant glucose monitoring.
Motivation
The solution:
•Painless
•Reduces patients time spent suffering from
hyperglycemia
•Monitor glucose at different locations
•Determine damage to specific tissue
•“Onboard sensors”
Methods
Focus of this work is to study the interaction and sensing characteristics
of nanorobots using NCD (nanorobot control design) software.
 Computational nanotechnology
 Simulation
 Physical parameters
 Device design
Computational nanotechnology
 Powerful tool for designing devices at
nanoscale.
 Research on using nanosensors in
therapeutic treatments and medical
instrumentation.
 Kinematic aspects for propulsion about
nanorobots inside-body locomotion.
Simulation
•List of positions and orientations of all objects in the task environment.
•List includes : all information relevant to the nanorobots interactions.
•Introduces RBCs with the fluid.
Simulator includes:
•Physical behavior
•Sensory information
•Visual display of the environment
•Monitor glycemic levels
Physical parameters
•Genome analysis used to identify
SGLT3 .
What is SGLT3 ?
Along with other functions , responsible
for regulating extracellular glucose
concentration. serves as a transducer.
•Chemical biosensors to determine any
medical action required.
•Nanobioelectronics as prototyping
methodology for hardware architecture.
Characteristics of nanorobots:
1. Biocompatibility
2. Chemosensor
3. CMOS IC nanobiosensor
Device design
 Nanorobot:

Exterior consists of carbon metal nanocomposites (diamond-like).
 Artificial glycocalyx surface .
 Integrated nanoelectronics for (RFID) CMOS transponder system.
 3-D microenvironment :

3D real time visualization
 Physical shape discription
 Physiological fluid flow patterns
Nanorobot Architecture
How should the nanorobot be designed?
Integrated Circuit
Integrated Circuit Block Diagram
Nanorobot Architecture
What materials should be used?
 CNTs in CMOS used as
a nanobiosensor
 Relaxed SiGe


Reduce self-heating
Improves performance
Nanorobot Architecture
How will it be powered?
Nanorobot Architecture
How will the data be transmitted?
-Acoustic
-Light
Nanorobot Safety
Will nanorobots react in our body?
Choose a proper membrane polymer material to
prevent the action of enzymes.
Nanorobot Safety
How will you get the nanorobots out of your body?
Enzymes inside the
nanorobot can be released
once a signal has been sent.
Advantages
 3 samples of blood daily vs. once every 90 days
 Reliability
 Comfort
Results
• Simulated environment : 36 C , pH of 7.4
• BGLs are transferred every 2 hours
• Biosensor achieved 90% of steady state signal in 90 ms
• Every 2 hours sensor is activated for 2 minutes.
Conclusions
 Use of nanorobots in the medical field is more precise and
efficient than conventional medical practices
 Nanorobots enable a more effective diabetes treatment
 3-D simulators can be used as nanomechatronic systems
that provide physical and numerical information for
nanorobot task-based modeling
 Medical nanorobots may be buildable 10-20 years from
today using an advanced molecular manufacturing
technology
Further Research
 More functions should be included in the nanorobot.
 Consider how the electrical impulse in our body will
affect the electrical components of the nanorobot.
 Make technology accessible to the
public (optimize cost)
References
 A. Cavalcanti et el. Medical nanorobotics for diabetes control
 A. Ummat et al. Nanorobotics
 A. Cavalcanti, B. Shirinzadeh, T. Fukuda, S. Ikeda. Nanorobot for Brain
Aneurysm
 A. Cavalcanti, Assembly Automation with Evolutionary Nanorobots
and Sensor-Based Control applied to Nanomedicine
Team U4 Rebuttal
NanoRobots in medicine
Team U4:
•
•
•
•
Aziz Daabash
Brett Michalk
Amanda Mogollon
Derek Nelson
http://www.cartoonstock.com/newscartoons/cartoonists/bst/lowres/bstn464l.jpg
•
Effective areas :
– The presentation was well organized and Informative.
– Interesting topic that has a huge potential in the medical field.
– Showing appropriate YouTube videos, nice and innovative use of graphics.
– Oral presentation and eye contact.
– Both presenters looked professional and dressed up.
– Speakers were knowledgeable of subject and had done a good amount of research on the topic.
– Innovative discussion of further research (ie. Use of iphone for energy supply)
•
Our answers to the following comments:
– How nanorobots operate/move (further discussion)
This was mentions on slides 14 and 15.
– Showing pictures of actual nanorobots instead of computer generated ones
Nanorobots do not exist yet , current research is only based on theory and computer simulations.
– Choose one particular nanorobot
our presentation specifically explained medical nanorobots for drug delivery.
– References and pictures citations are missing:
references were shown at the end of the presentation, as for the picture citation, the wrong slides were update
to the class website.
– Outline of the presentation is missing.
we have orally mentioned the outline of the presentation at the beginning of the lecture.
–
–
–
–
–
Didn’t mention nanorobot safety and future applications.
nanorobot safety was discussed , refer to slide 16. nanorobots ARE future applications that haven't
been produced yet.
Improve transitions flow.
after the first speaker finished his section he proceeded to shif the presentation to the next
presenter by introducing their name and what will they be talking about.
What types of nanorobots are proposed and what are their potential uses for each type?
as mentioned in the presentation , the proposed nanorobots were propsed to be used as drug
delivery method, as for their specific technical type, the research paper did not mention any
information related to this.
Are there any methods in fabricating/manufacturing these nanorobots suggested?
the researched paper had no information on how these nanorobots fabricated/manufactured.
I would like to know more about the relaxed SiGe integration into the nanorobot fabrication.
details about the relaxed SiGe integration into the nanorobot fabrication was not mentioned in the
researched paper. But further information can be found at the following link:
http://www.nanorobotdesign.com/papers/cancer.pdf page 2
–
•
Are the nanorobots actively activated or passively activated? How can these robots do their
functions if they are coated in an enzyme that will nullify the activation of antibodies in the
bloodstream? Will it somehow open up the cover and work on the parts of the body? Is that any
potential harm in the body?
we have mentioned in class that these robots use enzyme reaction to target specific tissue or cells of
the body to deliver the drug , specific amino acid sequance will trigger the activation of these
nanorobots. Potential harm of these nanorobots was mentioned in the slides, refer to slides 16 and
17.
Areas of improvement:
– Text size was too small on some slides and some slides were too busy.
– References
– inconsistent font size and style.
– Some hesitation at the beginning of the presentation.
Submitted by U1
Positive Aspects
 Well organized
 Included an outline of the presentation
 Followed outline
 Slides titles matched outline
 Informative
 How they work
 Applications
Negative Aspects
 Text size
 Too small on some slides
 Some slides are too busy
 Too much text/too small
 Should split into several slides
 References
 Should show when background information stops and
paper review begins
Possible further discussion
 More info on how nanorobots operate/move
 Show pictures of actual nanorobots instead of artists’
renditions
 Choose one particular nanorobot to explain in detail in
addition to the generalities provided.
Review of Group U4’s Presentation-
By Group U2:
-Kyle Demel
-Keaton Hamm
-Bryan Holekamp
-Rachael Houk
http://www.foresight.org/nanomedicine/gallery/Images/alveoli.jpg
The presenters did really well at:

Showing appropriate YouTube videos
http://www.christmas
tree.org/youtube.jpg
 Nice and innovative use of graphics

Explaining the content of the slides
 Oral presentation was very thorough

Making eye contact with the audience
The presenters could improve at:

Making similar slides more consistent Titles and text were different sizes
 Different formats: paragraph, bullets...


http://www2.ensi-bourges.fr/ws_nanorobotics/MR-2048-large.jpg
Cite all pictures and graphics
Outline in beginning of presentation What will you talk about?
 In what order will you talk about it?



Parts of presentation felt out of order
Perhaps discuss nanorobot safety and
architecture after finishing the results and
conclusion of article
Discuss additional future applications
http://www.technovelgy.com/graphics/content/cell-repair-nanorobot2.jpg
Group U3 Review





Great attention getter (first slide)
3d visualization pictures were very helpful
Some of the font could have been enlarged
Further research section could have been
more detailed
Explain a few of the pictures more thoroughly




Very educational and informative
presentation
Great eye contact
Both presenters looked professional and
dressed up
Could improve on making transitions flow a
little smoother
Nanorobots in Medicine
 Review of Team U4 by




Team U5 –
Jaynesh Shah
Greg Pudewell,
Edwin L. Youmsi Pete
John Pack.
Oral and Quality of Slides
Review
 Speakers did a good job in
the oral aspect of the
presentation. They were
loud and clear confident.
Implying they had done a
good amount of research on
the topic.
 The slides clear, visible and
not overcrowded. Team U4
made good use of several
pictures, images and graphs.
Technical Review
 The presentation was
satisfying from a
technical standpoint
 We would have liked
them to discuss the use
of nanorobots in
conjunction with the
iPhone or other
electronic devices
more
NANO-ROBOTS
Presented by: Group U4
Critiqued by: Group U6
CRITIQUE: ORAL PRESENTATION & SLIDES

Slides were very easy to read

good background and font color
The use of illustrations complimented the text
 Figures were relevant to the topic on the slide,
and helped convey key points
 Speakers had good voice projection to
the back of the room
 Speakers did well in maintaining eye
contact most of the time
 However, there was a little hesitation in giving
the lecture – maybe more practice would help

CRITIQUE – TECHNICAL CONTENT
Excellent topic – will be relevant for millions of
people worldwide
 Research paper was based on theoretical
simulations only – further research needs to be
done to increase the functionality of the nanorobots
 Introduction and explanation of research paper
was excellent, and presented in a way which was
very easy to understand
 We personally thought that the use of
cell phones to charge the robots and
receive information from the robots
was very innovative

Review for U4
Jung Hwan Woo
Review
• What types of nanorobots are proposed and what are their
potential uses for each type?
• Are there any methods in fabricating/manufacturing these
nanorobots suggested?
• I would like to know more about the relaxed SiGe integration into
the nanorobot fabrication.
• Are the nanorobots actively activated or passively activated?
• How can these robots do their functions if they are coated in an
enzyme that will nullify the activation of antibodies in the
bloodstream? Will it somehow open up the cover and work on the
parts of the body? Is that any potential harm in the body?
• What kind of software is currently used to simulate these
nanorobots?