1. food and drink
2. beverages
3. non alcoholic beverages
4. bottled water

Preventive Care Solutions
Clinpro™ White Varnish
With Tri-Calcium Phosphate
It’s good to
have a little
extra protection
Clinpro™ White Varnish keeps getting better –
now with TCP
3M ESPE’s exclusive TCP offers
more protection. Clinpro™ White Varnish
with Tri-Calcium Phosphate (TCP) is a
proprietary formula that contains fluoride, calcium and phosphate –
components naturally found in saliva. This exclusive TCP technology
has been customized to work with Clinpro White Varnish to deliver
targeted and sustained fluoride and calcium release.
During the manufacturing process, a protective barrier is created
around the calcium allowing it to coexist with the fluoride. After
application, Clinpro White Varnish flows across tooth surfaces
and comes in contact with saliva, releasing calcium and fluoride.
As the varnish moves, more varnish material is exposed to
saliva allowing additional fluoride and calcium to be released
on the tooth surface. This process enables Clinpro White Varnish
to continuously release fluoride AND calcium over the life of the
varnish – up to 24 hours!
TCP (Protected CaOn)
Fluoride
Saliva activates the protected calcium compound at
the tooth surface, causing it to be released together
with fluoride.
Varnish coating
Immediate and long-lasting occlusion.
Occluding dentinal tubules in-office provides immediate relief
from pain associated with the movement of fluid through open
tubules. Clinpro White Varnish penetrates and seals dentin tubules.
Clinpro White Varnish enters and blocks tubules.
SEM image at 1500X magnification
SEM image at 1500X magnification
Clinpro™ White Varnish covers and occludes open
tubules for immediate relief.
After the bulk of the varnish has been removed from
the surface, Clinpro™ White Varnish continues to block
tubule openings for long-lasting protection.
Tooth
Saliva
Less
sensitivity
Few patients can identify
WHICH tooth is the cause
of their discomfort.*
Clinpro White Varnish spreads to more tooth
surfaces, offering a distinct advantage in
the treatment of hypersensitivity, where the
pain may be related to several tooth surfaces,
including those in interproximal areas.
* Source: Gillam DG, Seo HS, Bulman JS, Newman HN; Jour of Oral Rehab,
1999;26:710-714
Source: 3M ESPE internal data
_SEM; n=20)
(+
Mean Number of Tooth Surfaces
where Varnish was Reported
10.0
5.0
_SEM; n=20)
(+
Number of Tooth Surfaces
0.0
Delivers
more
fluoride.
20.0
1 Hour Assessment Time (post-application)
5.0 +
( _SEM; n=20)
Mean Fluoride Concentration After 1 Hour
1 Hour Assessment Time (post-application)
7.0
6.0
5 min.
5.0
Mean Salivary Fluoride
Concentration after 1 Hour
4.0
3.0
0 cm
_SEM; n=20)
(+
2.0
8.0
1.0
7.0
0.0
6.0
1 cm
Competitive
5% NaF Varnish
1 min.
ppm F
10 sec.
Competitive
5% NaF Varnish
Concentration after 1 Hour
8.0
0.0
Vertical Flow Test
Vanish™ 5% Sodium Fluoride
White Varnish
Because of this ability to flow across and between teeth, more
15.0
varnish reaches more tooth surfaces – and more fluoride is
Salivary
released
in the
mouthFluoride
compared to competitive varnish tested.
10.0 Mean
Clinpro ™
White Varnish
How does Clinpro White Varnish get into the hard-to-reach
places? It flows better than other varnishes tested, and doesn’t
just harden and stop where applied. Clinpro White Varnish
remains fluid longer, and continues to flow from treated to
untreated tooth surfaces – including interproximal areas.
0 sec.
Competitive
5% NaF Varnish
Flows better and reaches areas
traditional varnishes may miss.
15.0
Clinpro™
White Varnish
Number of Tooth Surfaces
20.0
Source: 3M ESPE internal data
4.0
3.0
3 cm
2.0
1.0Cumulative
Covers more tooth surfaces.
Clinical studies show that Clinpro White Varnish flows to more
than twice
asNumber
many tooth
surfaces
after application.
Mean
of Tooth
Surfaces
where Varnish was Reported
_SEM; n=20)
(+
In
Vivo Varnish Flow Test – After 1 Hour
10.0
5.0
0.0
Competitive
5% NaF Varnish
15.0
Clinpro™
White Varnish
Number of Tooth Surfaces
20.0
1 Hour Assessment Time (post-application)
Clinpro White Varnish was applied to 8 anterior maxillary surfaces
in vivo. After application, it moves across the teeth, penetrating
hard-to-reach places.
Source: 3M ESPE internal data
™
Mean Salivary Fluoride
Concentration after 1 Hour
_SEM; n=20)
(+
8.0
Calcium Release
0.0
Releases
calcium.
0.8
mcg Ca/cm2 Coating, Cumulativemcg Ca/cm2 Coating, Cumulative
Flow measured as the vertical distance Clinpro White Varnish travels in the
presence of water after initial application over time.
Source: 3M ESPE internal data
™
Competitive
5% NaF Varnish
ppm F
2 cm
Vanish™ 5% Sodium Fluoride
White Varnish
Clinical test shows Clinpro™ White Varnish provides higher average salivary fluoride
5.0levels in vivo.
0.7
Products that provide both fluoride and calcium are designed
0.6
to help increase formation of calcium fluoride on tooth surfaces,
0.5
including dentin tubules, to relieve hypersensitivity.
0.4
0.3
Cumulative Calcium Release
0.2
0.1
0.8
0.0
0.70
Cumulative Calcium Release
5
10
15
Hours
20
25
30
10
15
Hours
20
25
30
0.6
0.5
0.4
0.3
0.2
0.1
0.0
0
5
After application, Clinpro™ White Varnish continues
to release calcium ions over at least 24 hours.
Source: 3M ESPE internal data
Applying Clinpro™ White Varnish is easy
and it takes just seconds
Simply apply one thin coat, sweeping the brush across tooth surfaces –
and the Clinpro White Varnish formula does the rest.
• Sets in the presence of saliva – no drying needed
• Enhanced flow characteristics allow Clinpro White Varnish to reach
interproximal areas other varnishes may miss
No drying
• Covers and adheres to the areas where applied
1
The tooth surface(s) to be treated should
minimally be “toothbrush clean.” Can be
applied in the presence of plaque.
2
3
Open the unit dose package of Clinpro™ White
Varnish and mix.
Apply Clinpro™ White Varnish evenly in a thin
layer over treatment area(s) with sweeping,
horizontal brush strokes.
Better
protection made
easy
After application, instruct the patient to close his or her mouth to set the Clinpro™ White Varnish. Do not use suction.
Please refer to Instructions for use for more detailed information, as well as precautionary and warranty information.
Protection you can’t see.
Clinpro White Varnish is virtually invisible on the teeth –
but leaves a temporary thin coating so patients know
it’s working.
Immediately after Clinpro™ White Varnish was applied.
Summary of advantages
• Now contains an exclusive calcium
and phosphate ingredient
• 5 years of clinical success
• Contains 22,600 ppm fluoride
• Covers more tooth surfaces
to deliver fluoride
• Releases calcium
• Easy to apply
• Relieves hypersensitivity
Easy for you to use –
a better experience for your patients
Fluoride treatment has to be convenient. Clinpro™ White Varnish with an innovative Tri-Calcium Phosphate
(TCP) ingredient is simple to use and comfortable to wear. 3M ESPE formulated Clinpro White Varnish so
that the area to be treated needs to be only “toothbrush clean” – no complicated pretreatment is necessary.
It can even be applied if plaque is present.
Plus, it offers other great advantages
• The application takes just seconds
• The patient can eat and drink following
the application
• The color is similar to enamel, so it’s
virtually invisible
• Available in Mint flavor; sweetened
with xylitol
Clinically
proven
Clinpro™ White Varnish with our exclusive TCP
helps protect tomorrow’s smiles
Ordering Information
3M ESPE AG
ESPE Platz
82229 Seefeld · Germany
E-Mail: [email protected]
Internet: www.3mespe.com
Item No.
Product Information
12249
Clinpro™ White Varnish 50 Pack – Mint Flavor
50 unit-dose blister packets (0.5ml each) and applicator brushes in individual foil pouches; 1 patient pad; 60 dosage stickers;
Technique Card
12250
Clinpro™ White Varnish 100 Pack – Mint Flavor
100 unit-dose blister packets (0.5ml each); 100 applicator brushes; 2 patient pads; 100 dosage stickers; Technique Card
3M, ESPE and Clinpro are trademarks
of 3M or 3M ESPE AG.
© 3M 2010. All rights reserved.
01 (04.2010)