MEDIA RELEASE EMBARGOED UNTIL 4 NOVEMBER 2014, 2030H PRESIDENT’S SCIENCE AND TECHNOLOGY AWARDS 2014 HONOURS OUTSTANDING SCIENTIFIC TALENT FOR THEIR CONTRIBUTIONS TO SINGAPORE’S R&D LANDSCAPE Singapore – Eight of Singapore’s top research scientists and engineers have been conferred the 2014 President’s Science and Technology Awards (PSTA) by President Tony Tan Keng Yam at a ceremony held at the Istana on 4 November 2014. The PSTA are the highest scientific honours in Singapore and serve to recognise exceptional individuals and teams for their achievements in science and technology, and acknowledge their outstanding contributions to the research and development (R&D) landscape. The PSTA consists of the following awards: • President’s Science and Technology Medal (PSTM) • President’s Science Award (PSA) • President’s Technology Award (PTA) The Young Scientist Awards (YSA), organised by the Singapore National Academy of Science and supported by A*STAR, were also presented to three promising young researchers at the awards ceremony. Advancing Singapore’s healthcare and biomedical sciences This year, the President’s Science and Technology Medal was presented to Professor John Wong Eu-Li, currently Chief Executive of the National University Health System (NUHS), Isabel Chan Professor in Medical Sciences and Senior Vice President (Health Affairs) for the National University of Singapore (NUS), for Page 1 of 23 his distinguished and sustained contributions to Singapore’s healthcare and biomedical sciences research. Professor Wong, one of the pioneers in Singapore’s push for the biomedical sciences, was instrumental in shaping policies, recruiting top scientists and working with Singapore’s economic agencies to attract pharmaceutical companies to Singapore. Professor Wong has also championed translational clinical research and established the Cancer Therapeutics Research Group to bring together academic cancer centres from Singapore, Australia and across Asia to develop better treatments for cancers which predominantly affect Asian populations. The group has demonstrated major differences in the expression and treatment of common cancers between Asian and Caucasian populations, with implications for screening, drug efficacy and toxicity. This concept of an “Asian Phenotype” has since been identified as one of Singapore’s niches in translational research. By helping to establish and lead the NUHS, Professor Wong also brought together research, clinical care and education to advance health and the quality of healthcare in Singapore. His emphasis on the importance of multi-disciplinary collaboration and human capital development for Singapore’s healthcare and research landscape has resulted in the development of academic programmes that encourage interaction across disciplines at NUS. These collective efforts have led to international recognition for Singapore in the development of academic health systems. Besides hosting the first regional meeting of the World Health Summit in 2013, Singapore was also invited to be the first non-G8 member of the M8 Alliance of Academic Health System. Said Professor Wong, “I am deeply honoured to receive this prestigious award on behalf of the whole academic medical community in Singapore who have built on what our predecessors have bequeathed us. Harnessing research to develop solutions for our healthcare challenges and equipping the next generation of professionals with the skills to address them will make this a better Singapore and enhance the biomedical sciences as a key pillar of our economy.” Breaking new ground in graphene chemistry research The President’s Science Award was presented to Professor Loh Kian Ping from NUS for his breakthrough research in graphene chemistry. Graphene, termed a Page 2 of 23 ‘wonder material’ for its unique properties of strength, flexibility and electrical and thermal conductivity, holds huge potential for application in fields such as computing, energy and medicine. Focusing on the growth, processing and applications of diamond and graphene, Professor Loh has led his team to breakthroughs in controlling the electronic properties of graphene by applying varying degrees of strain and even in the use of graphene as a platform for growth of stem cells. He has led his team to solve a major challenge of graphene commercialisation - the large scale production of graphene, Such discoveries hold great promise for the applications of graphene, resulting in several patents and start-ups that have secured more than US$3 million in venture funding. These advances have also led to recognition of Professor Loh as a world leader in graphene chemistry research, putting Singapore on the world map in this emerging field. Envisioning the future for detection and treatment of eye diseases The President’s Technology Award was conferred on two teams for their outstanding contributions to R&D which led to the innovative use of technology to meet economic and social needs. The President’s Technology Award was presented to a team comprising Professor Wong Tien Yin from the Singapore National Eye Centre (SNEC), and Professor Wynne Hsu and Professor Lee Mong Li from NUS, in collaboration with the Singapore Eye Research Institute (SERI), and A*STAR’s Institute for Infocomm Research (I2R), for the development of a suite of novel eye image analysis technologies. This platform allows the doctors to detect and track the progression of three major eye diseases which cause blindness as well as to study the onset of systemic vascular diseases such as stroke, heart disease and diabetes. The platform uses advanced algorithms to enable automatic screening of retinal images and generation of medical reports at higher speeds and lower costs. These algorithms were validated through close collaboration with eye specialists and tested using an extensive retinal image database. The platform has since been adopted by six polyclinics, increasing productivity by replacing manual examination of retinal images for anomalies indicating disease. The technology has also been licensed and used by various universities, research institutes, hospitals and even in ophthalmic products. Page 3 of 23 The other winning PTA team comprises Professor Subbu Venkatraman and Professor Freddy Boey of Nanyang Technological University (NTU), and Associate Professor Tina Wong from SERI. They are receiving this award for the development of a platform for sustained release of glaucoma medication. Glaucoma is the leading cause of irreversible blindness globally, with Asians accounting for almost half of the world’s patient population. The platform utilises a single injection of nanomedicine for the delivery of medication for up to six months, effectively preventing blindness caused by patient non-compliance to the regimen of daily eye-drop treatment. The use of their innovative technology has been successfully tested through first phase in-man clinical trials. In addition, the team has also attracted interest from major pharmaceutical companies. The team has enriched Singapore’s innovation ecosystem by establishing a start-up to commercialise the technology. Congratulating the winners, Mrs Ow Foong Pheng, Permanent Secretary, Ministry of Trade and Industry and Chairman of the PSTA Main Selection Committee said, “This year’s winners demonstrate the high standard of research and talent that has enabled Singapore to be an innovation-driven economy. They have distinguished themselves in their ability to conduct excellent science and to translate their research into benefits for society and the economy.” Recognising the next generation of scientific leadership The Young Scientist Awards were given to three promising young research scientists and engineers. They are: Dr Zhang Baile from NTU, Dr Wang Qijie from NTU, and Dr Melissa Fullwood from the Cancer Science Institute of Singapore, A*STAR’s Institute of Molecular and Cell Biology (IMCB) and YaleNUS College. The Young Scientist Awards was presented to the winners by Mr S. Iswaran, Minister, Prime Minister’s Office, and Second Minister for Home Affairs and Trade & Industry. More information on the PSTA and YSA winners may be found in Annex B and Annex E respectively. _______________________________________________________________ Enclosed: ANNEX A – List of PSTA winners ANNEX B – Citations of PSTA winners ANNEX C – Fact sheet on PSTA selection committees Page 4 of 23 ANNEX D – Information sheet on YSA and list of YSA winners ANNEX E – Citations of YSA winners For media queries and clarifications, please contact: Vanessa Loh Senior Officer, Corporate Communications Agency for Science, Technology and Research Tel: +65 6826 6395 Email: [email protected] ________________________________________________________________ About the President’s Science and Technology Awards (PSTA) The President’s Science and Technology Awards (PSTA) are the highest honours bestowed on exceptional research scientists and engineers in Singapore for their excellent achievements in science and technology, and outstanding contributions to the development of the research and development landscape in Singapore. The PSTA were formerly known as the National Science and Technology Awards (NSTA), which was started in 1987. The elevation of the award to Presidential status in 2009 underpins Singapore’s efforts to raise the level of excellence in R&D and strengthen the growing community of scientific talent in Singapore. The PSTA consists of the following awards: • President’s Science and Technology Medal (PSTM) • President’s Science Award (PSA) • President’s Technology Award (PTA) President’s Science and Technology Medal (PSTM) The President’s Science and Technology Medal is awarded to outstanding individuals who have made distinguished, sustained and exceptional contributions and played a strategic role in the development of Singapore through the promotion and management of R&D. Recipients receive a specially designed gold medal and a citation. President’s Science Award (PSA) The President’s Science Award is presented to research scientists and Page 5 of 23 engineers in Singapore who have made outstanding contributions in basic research leading to the discovery of new knowledge or the pioneering development of scientific or engineering techniques and methods. Recipients will receive a crystal trophy, a citation and a prize of $50,000. President’s Technology Award (PTA) The President’s Technology Award gives recognition to research scientists and engineers in Singapore who have made outstanding contributions to research and development resulting in the invention or discovery of significant technology with industrial applications. Recipients will receive a crystal trophy, a citation and a prize of $50,000. ________________________________________________________________ About the Agency for Science, Technology and Research (A*STAR) The Agency for Science, Technology and Research (A*STAR) is Singapore's lead public sector agency that fosters world-class scientific research and talent to drive economic growth and transform Singapore into a vibrant knowledge-based and innovation driven economy. In line with its mission-oriented mandate, A*STAR spearheads research and development in fields that are essential to growing Singapore’s manufacturing sector and catalysing new growth industries. A*STAR supports these economic clusters by providing intellectual, human and industrial capital to its partners in industry. A*STAR oversees 18 biomedical sciences and physical sciences and engineering research entities, located in Biopolis and Fusionopolis, as well as their vicinity. These two R&D hubs house a bustling and diverse community of local and international research scientists and engineers from A*STAR’s research entities as well as a growing number of corporate laboratories. For more information on A*STAR, please visit www.a-star.edu.sg. Page 6 of 23 ANNEX A LIST OF PSTA WINNERS I) • II) • III) • President’s Science and Technology Medal (PSTM) Prof John Wong Eu-Li Isabel Chan Professor in Medical Sciences Chief Executive, National University Health System Senior Vice President (Health Affairs), National University of Singapore President’s Science Award (PSA) Prof Loh Kian Ping Department of Chemistry National University of Singapore President’s Technology Award (PTA) Team comprising: Prof Subbu Venkatraman School of Materials Science and Engineering Nanyang Technological University Associate Prof Tina Wong School of Materials Science and Engineering Nanyang Technological University, Singapore Eye Research Institute Prof Freddy Boey School of Materials Science and Engineering Nanyang Technological University • Team comprising: Prof Wong Tien Yin Singapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS Graduate Medical School, and National University of Singapore Prof Wynne Hsu Page 7 of 23 School of Computing, National University of Singapore Prof Lee Mong Li School of Computing, National University of Singapore Page 8 of 23 ANNEX B CITATIONS OF PSTA WINNERS PRESIDENT’S SCIENCE AND TECHNOLOGY MEDAL 2014 Professor John Eu-Li Wong Isabel Chan Professor in Medical Sciences Chief Executive, National University Health System Senior Vice President (Health Affairs), National University of Singapore “For his outstanding contributions to the scientific research and biomedical science communities, and his visionary leadership in healthcare and medical sciences in Singapore.” Professor John Eu-Li Wong is widely regarded as a visionary leader in healthcare, a key contributor to the development of biomedical sciences and a champion of multidisciplinary and translational research. His stellar career is distinguished by his deep passion as a physician, and his ability as a leader to inspire teams dedicated to developing multidisciplinary and translational solutions for improved patient care. Prof Wong is a renowned medical oncologisthaematologist, a master strategist and a respected administrator who has a strong focus on talent and the nurturing of young doctors, researchers and clinician-scientists. In the area of biomedical sciences and research, Prof Wong made distinguished contributions as a key member of the team to establish Singapore’s Biomedical Sciences Initiative in 2000 led by then A*STAR Chairman Mr Philip Yeo. He has served on the Biomedical Sciences Executive Committee from its inception, including chairing the Human Capital Working Group, and also served on the Translational Clinical Research Committee and the Industry Partnership Oversight Committee. He also contributed to mentoring bright young local clinicians and clinician-scientists, as well as recruiting top talent to Singapore from overseas. A keen champion of translational clinical research, Prof Wong drew on his extensive clinical experience to establish the Cancer Therapeutics Research Group in 1997. The group brought together academic cancer centres in Singapore, Australia and across Asia to develop better treatments for cancers which predominantly affected Asian populations. Prof Wong currently serves on the National Medical Research Council and was the Founding Chair of the Board of the Singapore Clinical Research Institute. Prof Wong’s keen insights as a master physician and academic and research leader have contributed greatly to the development of Academic Medicine in Singapore. He played a key role in establishing the National University Health System (NUHS), and currently serves as its Chief Executive. He was also the Founding Director of the National University Cancer Institute Singapore (NCIS). Under his leadership, NCIS has grown into a highly respected institution which provides outstanding clinical care and high quality training for cancer care specialists, professionals and researchers, as well as conducting high-impact and relevant research. Page 9 of 23 Prof Wong, who was Dean of Yong Loo Lin School of Medicine at NUS from 2003 to 2011, led the revamp of the curriculum into integrated tracks, emphasising the clinical relevance of basic science and early exposure of medical students to patients. He also pushed for improved patient care through multidisciplinary teams of healthcare professionals and scientists. He was instrumental in the formation of the first undergraduate nursing degree programme at the medical school, and raised the global profile of Singapore medicine through institutional partnerships with some of the world's leading medical institutions, including Harvard Medical School's Beth Israel Deaconess Medical Center. Prof Wong helped to steer developments in key multidisciplinary programmes that involved Medicine, Science, Computer Science, Dentistry, Engineering, Business, Arts and Social Sciences, and Public Policy. These programmes stretched across areas that include bioethics, health service research, epidemiology, genomics, proteomics, metabolomics, imaging, immunology, experimental therapeutics, tissue and bioengineering, molecular pathology, as well as medical and bioinformatics. As the Founding Chair of the Board of the NUS Graduate School of Integrative Sciences and Engineering (NGS), Prof Wong led efforts to enable top graduate students to work with some of NUS' best faculty in the physical, engineering, and biomedical sciences. Integrative approaches were introduced at NGS to address challenges in medicine, engineering and the life, physical, and computer sciences. Prof Wong obtained his MBBS from the National University of Singapore (NUS) and served his residency and fellowship at the New York Hospital-Cornell Medical Center, where he was the Chief Resident in Medicine, and Memorial Sloan-Kettering Cancer Center. Among many notable achievements, he represents Singapore in the M8 Alliance of Academic Health Centers and the Association of Academic Health Centers – International. He is a member of the Global Genomic Medicine Collaboration (G2MC) Steering Committee, the Nature Index Panel of Senior Medical Advisors, the International Editorial Board of the American Journal of Medicine, and the Editorial Board of the Journal of the American Medical Association. Prof Wong was also a member of the World Economic Forum’s Global Agenda Council on Personalized and Precision Medicine. For his outstanding contributions to the scientific research and biomedical science communities, and his visionary leadership in healthcare and medical sciences in Singapore, Professor John Eu-Li Wong has been awarded the 2014 President’s Science and Technology Medal. Page 10 of 23 PRESIDENT’S SCIENCE AWARD 2014 Professor Loh Kian Ping Department of Chemistry National University of Singapore “For his outstanding research on graphene chemistry” Professor Loh Kian Ping is a pioneer and a world leader in the area of graphene chemistry research. In the last decade, Professor Loh spearheaded an internationally acclaimed research effort on advanced carbon materials. He is one of the key driving forces behind carbon research efforts at the National University of Singapore (NUS) and in Singapore generally. His research focuses on the growth, processing and application of diamond and graphene with a view towards technological applications. Graphene is a one atom thick carbon sheet with huge technological potential. In 2010, the Nobel Prize in Physics was awarded for graphene research and since then, worldwide research efforts to study the properties and applications of this wonder material have intensified. Professor Loh’s outstanding work in this field has contributed significantly to Singapore’s position as a world leader in this hot research area. Over the past seven years, Professor Loh and his team have made fundamental breakthroughs in graphene research. These discoveries include controlling the electronic properties of graphene by applying varying degrees of strain; using graphene as an optical material to generate high energy laser pulses; using nano-graphene oxide to seed the growth of ice at room temperature; and using graphene as a platform for the growth of stem cells. Prof Loh’s work on graphene photonics was even highlighted by Prof Kostya S. Novoselov, winner of the 2010 Nobel Prize in Physics, in his Nobel Lecture. Beyond fundamental studies, Professor Loh’s work addresses engineering challenges such as the large scale synthesis of graphene. His team recently pioneered the growth and transfer of high quality graphene on silicon wafer in a single step, solving a major challenge critical for graphene commercialisation. This breakthrough was published in the highly prestigious scientific journal Nature in January 2014, winning recognition in the scientific community worldwide. Most importantly, the direct growth and spontaneous attachment of graphene on the silicon substrate is amenable to batch processing in a semiconductor production line, thus speeding up the technological application of graphene. A prolific scientist, Professor Loh also invented a method to electrochemically exfoliate graphene flakes from graphite mineral. Unlike conventional methods, his novel method does not use oxidising agents or concentrated acids, thus bypassing the tedious and dangerous steps used in conventional methods. To commercialise this invention, Professor Loh founded a spin-off company in 2012 for bulk synthesis of high quality graphene for applications in batteries and composites. Trained as a physical scientist, Professor Loh’s work has a strong focus on applications. Out of the 10 patents that he has filed, five have been licensed and spawned three startups that secured more than USD 3 million in overseas venture funds. Page 11 of 23 In 2008, Professor Loh was awarded a National Research Foundation Competitive Research Programme (CRP) for research on graphene and related materials. This highly successful programme led by him has contributed to the establishment of the Graphene Research Centre at NUS Faculty of Science. By 2013, research arising largely from this CRP had propelled NUS to be one of the top universities in the world for graphene research. Over the last three years, Professor Loh had published more than 10 papers in Nature and its sister journals, among many other high impact papers. These achievements have contributed towards strengthening NUS’ international reputation and research rankings. Professor Loh has won many accolades for his outstanding research achievements. In 2008, he received the NUS Young Research award and in 2012, he was conferred the NUS Outstanding Researcher Award. Professor Loh was also presented with the highly prestigious American Chemical Society Nano Lectureship award in 2013. He is currently the associate editor of the American Chemical Society Journal, Chemistry of Materials. For his outstanding research on graphene chemistry, Professor Loh Kian Ping has been awarded the 2014 President’s Science Award. Page 12 of 23 PRESIDENT’S TECHNOLOGY AWARD 2014 Professor Subbu Venkatraman1, Associate Professor Tina Wong1, 2 and Professor Freddy Boey1 1 School of Materials Science and Engineering Nanyang Technological University 2 Singapore Eye Research Institute “For their innovative application of nanostructures and novel drug delivery approach to combat blindness from glaucoma” Professor Subbu Venkatraman, Associate Professor Tina Wong and Professor Freddy Boey have developed a simple and painless injection of anti-glaucoma nanomedicine that can effectively control the disease for several months. This sustained release nanomedicine treatment administered by doctors would overcome sub-optimal management of glaucoma due to patients’ non-compliance to daily topical application of eye drops and poor drug penetration from eye drops, leading to progression of blindness. This novel approach could change the paradigm of clinical management of glaucoma and could also potentially be applied to treatment of other diseases. Glaucoma is the leading cause of irreversible blindness worldwide and is estimated to affect 80 million people by 2020, with Asians accounting for almost half the world’s glaucoma afflicted population. For the last 150 years, doctors have been reliant on prescribing daily eye drops to early glaucoma patients to manage increase in ocular pressure – a treatment regime that is heavily reliant on patients remembering to use their eye drops correctly and regularly. The interdisciplinary team comprising Venkatraman, a biomaterials scientist, Wong, a senior consultant ophthalmologist and Boey, an experienced entrepreneur and bioengineer, worked together to address this challenge. The team developed a deep understanding of complex drug-nanostructure interactions and the loading principles of drugs into self-assembling nanocarriers such as liposomes. With this understanding, the team was able to load a sufficient amount of commonly used glaucoma medication into each nanoparticle, administer it through a sub-conjuctival injection and to control its release for 90 days in vivo. This is the first known injectable nanomedicine for glaucoma treatment. This avoids the risks and discomfort associated with sustained-release solid implants, whose drug efficacy may last up to 2 months in clinical trials. By administering anti-glaucoma treatment once three months via a single injection, the need for daily eye drop application with its associated risk of blindness from non-compliance and poor drug bioavailability was minimized. The team managed to advance their ocular nanocarrier research, application development and preclinical animal studies from concept through to successful first-inman clinical trials in just 4.5 years, which is about half the time of a typical drug commercialization cycle. This novel glaucoma nanomedicine treatment is expected to Page 13 of 23 be commercially available after larger scale clinical trials through a spin-off company in about two years and could significantly change the clinical management of glaucoma. In addition, the understanding of nanostructure-drug interactions and the nanocarrier drug delivery platform for glaucoma has opened the possibilities of this as a translatable platform technology to benefit other eye diseases as well as other applications requiring localized and systemic sustained delivery of drugs. For their innovative application of nanostructures and development of novel drug delivery approach to combat blindness from glaucoma, Professor Subbu Venkatraman, Associate Professor Tina Wong and Professor Freddy Boey are awarded the 2014 President’s Technology Award. Page 14 of 23 PRESIDENT’S TECHNOLOGY AWARD 2014 Professor Wong Tien Yin1, Professor Wynne Hsu2, Professor Lee Mong Li2 1 Singapore Eye Research Institute, Singapore National Eye Center, Duke-NUS Graduate Medical School, National University of Singapore 2 School of Computing, National University of Singapore “For their outstanding contributions to the development of novel ocular image analysis technology for the screening and evaluation of significant clinical problems in eye and vascular diseases” Professor Wong Tien Yin, Professor Wynne Hsu, and Professor Lee Mong Li, assisted by their collaborators from NUS, Singapore Eye Research Institute (SERI), and the Institute for Infocomm Research (I2R), developed a suite of novel ocular image analysis technologies and designed the architectural platform for the innovative application of these technologies to detect and track the progression of three major eye diseases which cause blindness. The technologies can also be used to study systemic vascular diseases. The core technology is the Platform for Ocular Image Screening and Evaluation (POISE) that encompasses a suite of advanced image analysis algorithms and innovative integration of these methods. These include programmes that have been developed for large-scale clinical use for eye diseases such as glaucoma, diabetic retinopathy and age-related macular degeneration as well as systemic vascular diseases such as stroke, heart disease, dementia, diabetes and hypertension. The technology has enabled monitoring and documentation of subtle alterations in the retina over time. This makes early recognition of such diseases possible before the onset of clinical symptoms, thus allowing physicians to detect disease early, monitor disease progression and track treatment outcomes. Through automation of ocular image analysis, previously labor-intensive eye disease screening programs can now be scaled up with reduced cost and less resource. The technology has been successfully adopted by public primary healthcare clusters and has significantly improved productivity, reduced waiting time and over-referrals to specialists. The team has benefitted from close collaboration with NUS, SERI and I2R colleagues. Their research and achievements have placed Singapore on the world map as a leader in ocular image analysis technology and development. The technology has been licensed to and used by several academic and medical centres and research institutions, including University College London, University of Wisconsin-Madison, University of Melbourne, University of Sydney, the Centre for Eye Research Australia, the Commonwealth Scientific and Industrial Research Organisation, Moorfields Eye Hospital and Topcon Inc. Several joint research labs such as SAILOR - the SERI-I2R-NUS Joint Page 15 of 23 Lab, and the ATLANTIA Topcon-I2R Joint Lab have been established to drive the next generation of advanced ocular imaging technologies. This work has resulted in more than 30 patents, and 20 end-user licenses with companies, institutions and hospitals globally full commercial licenses with multinational companies) ;more than 300 publications and multiple international prizes and awards. These systems have been extensively applied to different populations and cohorts in Singapore, USA, Europe, Australia and other Asian countries, in more than 100,000 adults and children ranging from healthy, community-based populations to high risk patient groups. For their outstanding contributions to the development of novel ocular image analysis technology for the screening and evaluation of significant clinical problems in eye and vascular diseases, Professor Wong Tien Yin, Professor Wynne Hsu, and Professor Lee Mong Li, are awarded the 2014 President’s Technology Award. Page 16 of 23 ANNEX C FACT SHEET ON PSTA SELECTION COMMITTEES Judging Process Nominations for the awards start from January every year, and ends with judging and endorsement of the awards in August. The nominations undergo a rigorous process of selection before being short listed for judging. Award Selection Committees The award selection panels comprised key representatives from the industry, academia, defence and research institutes. The main selection committee was chaired by Mrs Ow Foong Pheng, Permanent Secretary, Ministry of Trade and Industry. Professor Lee Eng Hin, Professor and Emeritus Consultant, National University Health System, and Professor Quek Tong Boon, Chief Defence Scientist, Ministry of Defence, chaired the selection committees for the President’s Science Award and President’s Technology Award respectively. Page 17 of 23 ANNEX D INFORMATION SHEET ON YOUNG SCIENTIST AWARD (YSA) List of YSA Winners Assistant Professor Wang Qijie School of Electrical and Electronic Engineering & School of Physical and Mathematical Sciences Nanyang Technological University Assistant Professor Zhang Baile Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University Assistant Professor Melissa Jane Fullwood Cancer Science Institute of Singapore National University of Singapore, Institute of Molecular and Cell Biology Agency for Science, Technology and Research, and Sciences Division Yale-NUS College About the Young Scientist Awards The Young Scientist Awards recognise young researchers, aged 35 years and below, who are actively engaged in R&D in Singapore, and who have shown great potential to be world-class researchers in their fields of expertise. This award is organised by the Singapore National Academy of Science and supported by A*STAR. Recipients will receive a trophy, a certificate of commendation and a prize of $10,000. Young Scientist Award Selection Committee The judging committee for the Young Scientist Awards is chaired by Professor Andrew Wee, President, Singapore National Academy of Science. Page 18 of 23 ANNEX E CITATIONS OF YSA WINNERS YOUNG SCIENTIST AWARDS 2014 Assistant Professor Wang Qijie School of Electrical and Electronic Engineering & School of Physical and Mathematical Sciences Nanyang Technological University “For his research on fundamental studies and applications in mid-infrared and far-infrared photonics and optoelectronics” Dr Wang’s main research interests are the filling of the mid-infrared and farinfrared spectrum gap through theoretical and experimental investigations of fundamental light-matter interactions in new materials and new designs, and the development of novel photonic and optoelectronic devices and systems (as well as solutions) for a wide range of applications from sensing and spectroscopy, free space communication, environmental monitoring and industry process control, imaging and security screening, to defence. He and his co-workers have made several major contributions, including an innovative approach through band structure and defect engineering of graphene to achieve broadband high photo response photo detectors, which open up possibilities for achieving high performance graphene optoelectronic devices, a spectral class of electrically pumped lasers in the mid-infrared regime without relying on a laser cavity, and a planar plasmonic integration for achieving ‘arbitrary’ beam characteristics of lasers. Dr Wang’s research has resulted in more than 90 papers in top international journals such as Nature Photonics, Nature Materials, Nature Communications, etc, as well as multiple US patents, some of which have been licensed to US companies. His achievements have been extensively featured in leading journals and the mass media: Nature, Nature Photonics, Laser Focus World, IEEE Spectrum, Physics World, New Scientist, Asian Scientist, Science Daily, Straight Times, Lianhe Zaobao, etc. Over the past five years, he has secured about S$8 million worth of competitive external research grants, for most of which he is the principal investigator. He won the international World Culture Council Special Recognition Award 2013, Nanyang Assistant Professorship 2009, IES Prestigious Engineering Achievement Award 2005, Singapore Millennium Page 19 of 23 Foundation Fellowship 2005, Gold Award in the 5th Young Inventor Awards 2004 (by Hewlett Packard), and the Young Inventor Award in Photonics Innovation Village Competition 2004 (France). Page 20 of 23 Assistant Professor Zhang Baile Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University (NTU) “For his research on fundamental as well as practical invisibility cloaking from light and heat” Dr Zhang’s research focuses on analysing and controlling electromagnetic waves, from radio to light. In the development of invisibility cloaking technology that originally seemed indistinguishable from magic, he established a solid electromagnetic foundation that solved major controversies in mathematics and physics, demonstrated macroscopic visible-light cloaks which had been widely believed to be impossible, and extended the cloaking technology from optics to thermal physics with the first successful three-dimensional thermal cloak that can hide an air bubble from external heat flux. With these results, his students won the £10,000 prize in the business plan competition called “CleanTech Challenge” in London in 2014 - the first winner from Asia. He also started a spin-off company in Singapore recently. Dr Zhang is a recipient of the MIT Technology Review TR35 Young Innovators Award 2012, which “recognizes the world’s most outstanding 35 innovators under the age of 35.” He was invited to give a TED Talk in Long Beach, California, in 2013, as the first Chinese TED Fellow. He serves on the Editorial Board of Scientific Reports, a new journal from Nature Publishing Group. He is an engaging educator and skilfully uses demonstrations in his lectures at NTU to effectively teach and engage even those uninterested in physics. Page 21 of 23 Assistant Professor Melissa Jane Fullwood Junior Principal Investigator Cancer Science Institute of Singapore National University of Singapore (NUS), Joint Principal Investigator Institute of Molecular and Cell Biology Agency for Science, Technology and Research (A*STAR), Assistant Professor Sciences Division Yale-NUS “For her research on chromatin interactions in cancer” Dr Fullwood’s research focuses on the study of 3-Dimensional genomic organization, or chromatin interactions, in cancer. Cancer genome sequencing has revealed that many factors associated with epigenetic processes are mutated in cancers, and epigenetic processes have been targeted by specific drugs. One of the mechanisms by which the non-coding "dark matter" of the human genome could function is through long-range chromatin interactions with target genes. Chromatin interactions are regions of the genome that are far apart in the linear genome sequence but come together in close 3-dimensional spatial proximity, and may constitute common mechanisms for gene regulation. Dr Fullwood previously helped to develop Chromatin interaction Analysis with Paired-End Tag Sequencing (ChIA-PET) for genome-wide elucidation of chromatin interactions, and applied this to the study of chromatin interactions bound by Estrogen Receptor α (a drug target in breast cancer), and demonstrated that chromatin interactions constitute a major mechanism by which Estrogen Receptor α functions to upregulate genes. In addition, she participated in the “ENCODE” consortium funded by the National Institutes of Health in the United States, where her work (and the work of other people), demonstrated that chromatin interactions are common mechanisms for transcription regulation. Now, in her independent laboratory, she is applying chromatin interaction methodologies to cancer models to investigate detailed epigenomic profiles, allowing for new insights into possible cancer-associated biomarkers and cancer therapies. This work is expected to have translational applications in terms of annotations for personal and clinical sequencing and development of clinical biomarkers. Page 22 of 23 Dr Fullwood has 17 publications in journals such as Nature, and her works have been cited over 1,500 times. She also holds several patents. She is a recipient of the Agency for Science, Technology and Research (A*STAR) National Science Scholarships, one of the three recipients of the inaugural L’Oreal-UNESCO for Women in Science National Fellowships in Singapore in 2009, and the international winner of the GE and Science prize in 2010. In 2013, she received the National Research Foundation (NRF) fellowship. She is the President of the Singapore Institute of Biology (SIBiol). 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