EUROPEAN RESPIRATORY journal CONTENTS VOLUME 44 / NUMBER 5 / NOVEMBER 2014 EDITORIALS 1103 Cough hypersensitivity syndrome: towards a new approach to chronic cough Roger Escamilla and Nicolas Roche 1107 Understanding the impact of physical activity in COPD outcomes: moving forward Richard ZuWallack and Cristóbal Esteban 1110 A conceptual framework for reporting experience of physical activity in COPD Enrico M. Clini and Laura Fregonese 1113 Double tracer gas single-breath washout: promising for clinics or just a toy for research? Philipp Latzin and Bruce Thompson 1116 Do we need new asthma control tests? Jean Bousquet, Arnaud Bourdin and Pascal Demoly 1119 Should use of 4 hours continuous positive airway pressure per night be considered acceptable compliance? Juan F. Masa and Jaime Corral-Peñafiel 1121 Microvascular disease in chronic thromboembolic pulmonary hypertension: the story continues William R. Auger and Nick H. Kim 1123 Negative clinical trials in sarcoidosis: failed therapies or flawed study design? David R. Moller European Lung Corner 1127 Implementing the European Respiratory Roadmap: halfway there? Nadia Kamel FROM THE MUSEUM 1130 From the Museum: the Art of Thinking. Part 9: Imagination Tom Kotsimbos ERS TASK FORCE REPORT 1132 Expert opinion on the cough hypersensitivity syndrome in respiratory medicine Alyn H. Morice, Eva Millqvist, Maria G. Belvisi, Kristina Bieksiene, Surinder S. Birring, Kian Fan Chung, Roberto W. Dal Negro, Peter Dicpinigaitis, Ahmad Kantar, Lorcan P. McGarvey, Adalberto Pacheco, Raimundas Sakalauskas and Jaclyn A. Smith ORIGINAL ARTICLES Cough 1149 A worldwide survey of chronic cough: a manifestation of enhanced somatosensory response Alyn H. Morice, Adam D. Jakes, Shoaib Faruqi, Surinder S. Birring, Lorcan McGarvey, Brendan Canning, Jaclyn A. Smith, Sean M. Parker, Kian Fan Chung, Kefang Lai, Ian D. Pavord, Jan van den Berg, Woo-Jung Song, Eva Millqvist, Michael J. Farrell, Stuart B. Mazzone, Peter Dicpinigaitis and The Chronic Cough Registry COPD ERJ Open 1156 Characterisation and impact of reported and unreported exacerbations: results from ATTAIN Paul W. Jones, Rosa Lamarca, Ferran Chuecos, Dave Singh, Alvar Agustí, Eric D. Bateman, Gonzalo de Miquel, Cynthia Caracta and Esther Garcia Gil 1166 Prospective validation of the endurance shuttle walking test in the context of bronchodilation in COPD Benoit Borel, Véronique Pepin, Donald A. Mahler, Éric Nadreau and François Maltais 1177 Mechanisms of exercise intolerance in Global Initiative for Chronic Obstructive Lung Disease grade 1 COPD Jordan A. Guenette, Roberto C. Chin, Sicheng Cheng, Paolo B. Dominelli, Natya Raghavan, Katherine A. Webb, J. Alberto Neder and Denis E. O’Donnell 1188 Skeletal muscle adiposity is associated with physical activity, exercise capacity and fibre shift in COPD Matthew Maddocks, Dinesh Shrikrishna, Simone Vitoriano, Samantha A. Natanek, Rebecca J. Tanner, Nicholas Hart, Paul R. Kemp, John Moxham, Michael I. Polkey and Nicholas S. Hopkinson ORIGINAL ARTICLES (CONTINUED) 1199 Changes in physical activity and all-cause mortality in COPD Anouk W. Vaes, Judith Garcia-Aymerich, Jacob L. Marott, Marta Benet, Miriam T.J. Groenen, Peter Schnohr, Frits M.E. Franssen, Jørgen Vestbo, Emiel F.M. Wouters, Peter Lange and Martijn A. Spruit 1210 Double tracer gas single-breath washout: reproducibility in healthy subjects and COPD Kim Husemann, Nina Berg, Jennifer Engel, Johannes Port, Christoph Joppek, Ziran Tao, Florian Singer, Holger Schulz and Martin Kohlhäufl Rehabilitation 1223 ERJ Open The PROactive innovative conceptual framework on physical activity Fabienne Dobbels, Corina de Jong, Ellen Drost, Janneke Elberse, Chryssoula Feridou, Laura Jacobs, Roberto Rabinovich, Anja Frei, Milo A. Puhan, Willem I. de Boer, Thys van der Molen, Kate Williams, Hillary Pinnock, Thierry Troosters, Niklas Karlsson, Karoly Kulich, Katja Rüdell and the PROactive consortium Asthma 1234 Human leukocyte antigen class II variants and adult-onset asthma: does occupational allergen exposure play a role? Lidwien A.M. Smit, David P. Strachan, Roel Vermeulen, Paul I.W. de Bakker, Florence Demenais, Orianne Dumas, Anne-Elie Carsin, Paul Cullinan, Ivan Curjuric, Rebecca E. Ghosh, Dick Heederik, Medea Imboden, Deborah Jarvis, Mark Lathrop, Nicole Le Moual, Amar Mehta, David Miedinger, Torben Sigsgaard, Valérie Siroux, David Vernez, Jan Paul Zock, Francine Kauffmann, Nicole Probst-Hensch, Manolis Kogevinas and Emmanuelle Bouzigon 1243 Development and validation of the RAND Asthma Control Measure Marielena Lara, Maria Orlando Edelen, Nicole K. Eberhart, Brian D. Stucky and Cathy D. Sherbourne Cystic fibrosis 1253 Cyanide levels found in infected cystic fibrosis sputum inhibit airway ciliary function Chandrika Nair, Amelia Shoemark, Mario Chan, Sarah Ollosson, Mellissa Dixon, Claire Hogg, Eric W.F.W. Alton, Jane C. Davies and Huw D. Williams Sleep 1262 Intensive versus standard follow-up to improve continuous positive airway pressure compliance Izolde Bouloukaki, Katerina Giannadaki, Charalampos Mermigkis, Nikolaos Tzanakis, Eleni Mauroudi, Violeta Moniaki, Stylianos Michelakis, Nikolaos M. Siafakas and Sophia E. Schiza Pulmonary vascular diseases 1275 Microvascular disease in chronic thromboembolic pulmonary hypertension: a role for pulmonary veins and systemic vasculature Peter Dorfmüller, Sven Günther, Maria-Rosa Ghigna, Vincent Thomas de Montpréville, David Boulate, Jean-François Paul, Xavier Jaïs, Benoit Decante, Gérald Simonneau, Philippe Dartevelle, Marc Humbert, Elie Fadel and Olaf Mercier Pulmonary infections CME article 1289 Mycobacterial diseases developed during anti-tumour necrosis factor- therapy Jung-Wan Yoo, Kyung-Wook Jo, Bo-Hyung Kang, Mi Young Kim, Bin Yoo, Chang-Keun Lee, Yong-Gil Kim, Suk-Kyun Yang, Jeong-Sik Byeon, Kyung-Jo Kim, Byong Duk Ye and Tae Sun Shim Sarcoidosis 1296 Safety and efficacy of ustekinumab or golimumab in patients with chronic sarcoidosis Marc A. Judson, Robert P. Baughman, Ulrich Costabel, Marjolein Drent, Kevin F. Gibson, Ganesh Raghu, Hidenobu Shigemitsu, Joseph B. Barney, Daniel A. Culver, Nabeel Y. Hamzeh, Marlies S. Wijsenbeek, Carlo Albera, Isham Huizar, Prasheen Agarwal, Carrie Brodmerkel, Rosemary Watt and Elliot S. Barnathan REVIEW 1308 Inhaled antibiotics: dry or wet? Harm A.W.M. Tiddens, Aukje C. Bos, Johan W. Mouton, Sunalene Devadason and Hettie M. Janssens BACK TO BASICS 1319 Interleukin-17 cytokine signalling in patients with asthma Anders Lindén and Barbro Dahlén STATE OF THE ART 1332 SERIES “MULTIMORBIDITY AND THE LUNG” Edited by L.M. Fabbri and J.M. Drazen Number 3 in this series Ageing and the border between health and disease William MacNee, Roberto A. Rabinovich and Gourab Choudhury AGORA Research letters 1353 Small airway dysfunction is associated with poorer asthma control Arvind Manoharan, William J. Anderson, Joseph Lipworth, Ibrahim Ibrahim and Brian J. Lipworth 1355 Reduced lung function and the risk of out-of-hospital sudden cardiac death Sudhir Kurl, Sae Young Jae and Jari A. Laukkanen 1357 Autonomic dysregulation: a mechanism of asthma death Jaymin B. Morjaria, Tim Rowland, Puneet Tailor, Shaan Hyder, Caroline E. Wright, Simon P. Hart and Alyn H. Morice 1361 Earlier decline in sniff nasal inspiratory pressure than peak expiratory flow in children with Duchenne muscular dystrophy Véronique Nève, Jean-Louis Edmé and Régis Matran 1363 Low socioeconomic status is associated with worse lung function in the Danish cystic fibrosis population David C. Taylor-Robinson, Karsten Thielen, Tania Pressler, Hanne V. Olesen, Finn Diderichsen, Peter J. Diggle, Rosalind Smyth and Margaret Whitehead 1366 The impact of novel tests for tuberculosis depends on the diagnostic cascade Amanda Y. Sun, Claudia M. Denkinger and David W. Dowdy 1369 An evaluation of the use of a negative interferon- release assay for tuberculosis screening before TNF antagonist therapy Georgia Woodfield, Benjamin Passey-Heaton, Anob Chakrabarti, Anton Pozniak and Michael R. Loebinger 1373 Prevalence, screening and treatment of latent tuberculosis among oral corticosteroid recipients Nicholas T. Vozoris, Julie Seemangal and Jane Batt ERJ Open Correspondence 1376 Comparison against baseline in randomised control trials (again) John D. Blakey; Sérvulo Azevedo Dias-Júnior, Rafael Stelmach, Regina Maria de Carvalho-Pinto and Alberto Cukier 1377 International European Respiratory Society/American Thoracic Society guidelines on severe asthma Jean Bousquet, Nikolai Khaltaev, Alvaro Cruz, Arzu Yorgancioglu and Alexander Chuchalin; Kian Fan Chung and Sally Wenzel for the European Respiratory Society/American Thoracic Society Severe Asthma International Guidelines Task Force 1379 Hot tub Legionella pneumonia outbreak Maryam Ahmed and Naveed Mustfa Commentary 1382 Pulmonary rehabilitation in Italy: professional barriers to overcome Bruno Balbi, Nicolino Ambrosino, Marta Lazzeri, Franco Pasqua, Michele Vitacca and Enrico Clini f,h,l,m MEETING CALENDAR