Digital Pathology Congress 4-5 December 2014, London, UK www.globalengage.co.uk/digital-pathology.html
4-5 December 2014, London, UK www.globalengage.co.uk/digital-pathology.html Digital Pathology Congress UNDERSTANDING & UTILIZING DIGITAL PATHOLOGY AS A TOOL FOR ADVANCING PATHOLOGY PRACTICE & ENABLING ENHANCED PATIENT CARE Global Engage is pleased to announce their inaugural Digital Pathology Congress which will be held on December 4-5 in London, UK. The conference is part of their successful Drug Discovery series which includes events on precision medicine, orphan drugs, synthetic biology, the human microbiome and digital PCR. The continuing growth and advances in digital pathology solutions is transforming the industry. With wide ranging applications and benefits including reduction in lab costs, increased workflow efficiency, greater interconnectivity, effective training / education methods, improved decision making is enabling enhanced patient care. The result is that Digital Pathology is rapidly gaining momentum worldwide. Attracting over 200 industry & academic experts working in all areas of Pathology this two day interactive meeting will provide the opportunity to take home cutting edge strategies, analysis techniques, case study examples and methods to allow you to fully understand both the technology and accompanying informatics and image analysis tools and utilize digital pathology to its greatest potential. This will be achieved through a vibrant exhibition room full of technology providers showcasing their technologies and other solutions, networking breaks allowing interaction with your peers, poster presentation sessions, expert led case study presentations and incisive Q&A panel discussions during three separate tracks which will examine the topics below. Confirmed Speakers Include: Jo Martin Liron Pantanowitz Marcial Garcia Rojo National Clinical Director of Pathology NHS England, Professor, Queen Mary University of London, Director of Academic Health Sciences, Barts Health NHS Trust Associate Professor of Pathology & Biomedical Informatics, Director of the Pathology Informatics Fellowship Program University of Pittsburgh Medical Center Head of Pathology Department. Hospital de Jerez de la Frontera, Cádiz, Spain Conference Synopsis Day 1 Day 2 Digital Pathology - Strategy and Technology Introduction, benefits & future developments of Digital Pathology Implications on pathology practice o Uses in education and training Converting to/ integration of digital pathology Technology advances in digital pathology Digital Pathology project updates Standardisation in Digital Pathology Quality control and improvement Validation Panel Discussion – Overcoming barriers in adoption of Digital pathology Digital Image Analysis Overcoming challenges in image analysis o Image standardization o Compression techniques Analysis software Automated image analysis Quantitative image analysis research Visualization methods for diagnosis and prognosis Annotation tools Pattern recognition Scoring Algorithm development / Image analysis algorithms Pathology Informatics Acquisition, processing, archiving & retrieval of WSI Cloud Computing Access through mobile devices Pathology PACS Automation Improving WSI workflow efficiency Telepathology o Virtual networks o Use in remote areas Telediagnosis Pathology IT Digital Pathology Applications and Research Case Studies Research case studies utilizing digital pathology in Clinical trials Diagnosis Diagnostics Next generation sequencing Biomarker analysis /research / quantification Tissue-based research / imaging Biobanking Precision / personalised medicine Image analysis For more information please contact Steve Hambrook, Conference Director, Global Engage Ltd. [email protected] +44 (0) 1865 849841 Digital Pathology Congress – 4-5 December 2014, London, UK Confirmed Speakers Paul van Diest, Head of Department, Professor in Pathology, University Medical Center Utrecht, Netherlands Yukako Yagi, Director of Pathology Imaging and Communication Technology Center, Massachusetts General Hospital and Harvard Medical School, USA Johan Lundin, Research Director and Professor of Medical Technology, Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland and Karolinska Institutet, Stockholm, Sweden Arvydas Laurinavičius, Director National Pathology Center, Vilnius University Hospital Santariskes Clinics, Lithuania Toby Cornish, Assistant Professor of Pathology, Division of Gastrointestinal and Liver Pathology, Johns Hopkins School of Medicine, USA Will Howat, Head of Histopathology/ISH, Cancer Research UK Mogens Vyberg, Professor of Clinical Pathology, University of Aalborg, Denmark Marielle Odin, Director of Pathology, Roche, Germany Jeroen van der Laak, Assistant Professor in Digital Pathology, Dept of Pathology, Radboud University Nijmegen Medical Centre, The Netherlands Eric Verbeeken, Professor, The Translational Cell and Tissue Research Group, KU Leuven, Belgium Janina Slodkowska, Department of Pathology, Consultant Specialist, Military Institute of Medicine, Poland Kate Lillard, Chief Scientific Officer, Indica Labs Inc. Peter Hamilton, Vice President for Research and Development, PathXL Bruce Tanchel, Consultant Histopathologist, Heart of England NHS Foundation Trust, UK David Snead, Consultant Histopathologist and Clinical Service Lead, Coventry and Warwickshire Pathology Services, UK Daniel Racoceanu, Professor, Sorbonne Universités, Université Pierre et Marie Curie (UPMC) & Adjunct Professor, National University of Singapore (NUS) Keith Kaplan, Pathologist, Charlotte, NC, USA Rob Goldin, Professor of Liver & GI Pathology, Faculty of Medicine, Department of Medicine, Imperial College London, UK Stephen Schmechel, Associate Professor, Chief of Pathology (Acting), Harborview Medical Center, Department of Pathology, University of Washington School of Medicine, USA Klaus Kayser, Professor, Institute of Pathology, Humboldt University, Germany Gloria Bueno, Professor, VISILAB – School of Engineering, Universidad de Castilla-La Mancha, Spain Niels Grabe, Head, Hamamatsu Tissue Imaging and Analysis Center, Heidelberg University, Germany Friedrich Feuerhake, Neuropathologist, Institute of Pathology, Hannover Medical School, Germany Jorma Isola, Professor of Cancer Biology, University of Tampere, BioMediTech, Finland Michael den Bakker, Consultant Histopathologist Department of Pathology, Maasstad Hospital, The Netherlands Sanja Stifter, Associate Professor, Department of Pathology, Faculty of Medicine, University of Rijeka, Croatia Sebastian Brandner, Professor and Chair of Neuropathology, Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, and Dept. of Neurodegenerative Disease, UCL Institute of Neurology, UK Alison Bigley, Associate Principal Scientist, Investigative & Translational Pathology, AstraZeneca, UK Han van Krieken, Full Professor, Pathology, Radboud University Medical Center Venue London Heathrow Marriott Hotel Bath Road Hayes, UB3 5AN United Kingdom A discounted group rate is available to all attendees. Details of how to book are available on registration. Space is limited and accommodation is available on a first come basis. For more information please contact Steve Hambrook, Conference Director, Global Engage Ltd. [email protected] +44 (0) 1865 849841 Digital Pathology Congress – 4-5 December 2014, London, UK Gold Sponsors Silver Sponsors Sponsors Supporters For more information please contact Steve Hambrook, Conference Director, Global Engage Ltd. [email protected] +44 (0) 1865 849841 Agenda: Day One Thursday, 4th December 2014 08.00-08.50 08.50-09.00 09.00-09.30 Keynote Address - Title to be Confirmed Registration & Coffee Global Engage Welcome Address CONFIRMED: Jo Martin, National Clinical Director of Pathology NHS England, Professor of Pathology, Queen Mary University of London, Director of Academic Health Sciences, Barts Health NHS Trust 09.30-10.00 Keynote Address Pros & Cons of Digital Pathology Digital imaging has gained much traction in pathology globally. This keynote address will discuss: The benefits of digital imaging and how these have been leveraged in the field of pathology. The challenges that have to be overcome to see more widespread adoption of digital pathology. Recent advances in technology and highlight future trends in digital pathology. CONFIRMED: Liron Pantanowitz, Associate Professor of Pathology & Biomedical Informatics, Director of the Pathology Informatics Fellowship Program and Associate Director of the Pathology Informatics Division at the University of Pittsburgh Medical Center, USA 10.00-10.30 Solution Provider Presentation Digital Pathology the Heart of the Lab, The Birmingham Heartlands Experience Our experience at Birmingham Heartlands Hospital in trying to implement Digital Pathology into a real NHS Trust I will discuss the challenges and difficulties we have faced and the successes we have had, including some unexpected ones I will discuss how I see the future of Digital Pathology in the NHS Bruce Tanchel, Consultant Histopathologist, Heart of England NHS Foundation Trust, UK Sponsored by 10.30-11.40 Morning Refreshments & Poster Presentation Sessions One-to-One Meetings Digital Pathology Application and Research Case Studies Pathology Informatics 11.40-12.05 Digital Pathology And Tissue - Based Diagnosis. How do they Semantics at the Helm and Scalability in Wholes Slide Image Differ? Exploration. How this could be Helpful for Big Data in HighContent Microscopy? Semantics and imaging scalability are key issues in high-content microscopy. After presenting an overview of massive data challenges already knocking at the door of microscopy, we briefly present some of our results on the path of highly efficient and scalable analysis of massive whole slide images. CONFIRMED: Klaus Kayser, Professor, Institute of Pathology, Humboldt University, Germany 12.05-12.30 Digital Pathology: Applications from Research to Clinical Trials CONFIRMED: Niels Grabe, Head, Hamamatsu Tissue Imaging and Analysis Center, Heidelberg University, Germany 12.30-13.00 Solution Provider Presentation Big Data – Short Learning Curve: A New Paradigm in Digital Pathology Image Analysis. It’s about time – go from digital slide to image analysis results faster with HALO and HyperCluster technology CONFIRMED: Kate Lillard, Chief Scientific Officer, Indica Labs Inc. CONFIRMED: Daniel Racoceanu, Professor, Sorbonne Universités, Université Pierre et Marie Curie (UPMC), France & Adjunct Professor, National University of Singapore (NUS) Development of Image Quality Assessment and Color Standardization System for WSI Or Histology 3D Imaging or Multimodality 3D Imaging To use WSI in Research and Clinical Diagnostic purpose, the “accuracy” of image data (color and quality) is very important. Easy evaluation methods of appropriate image quality and Color Standardization are necessary Latest version of Color Standardization System and Image Quality Assessment System will be introduced. CONFIRMED: Yukako Yagi, Director of the MGH Pathology Imaging & Communication Technology (PICT) Center Massachusetts General Hospital; Affiliated Faculty, Wellman Center for Photomedicine, Massachusetts General Hospital; Assistant Professor of Pathology, Harvard Medical School, USA Solution Provider Presentation For sponsorship opportunities please contact Steve Hambrook at [email protected] For more information please contact Steve Hambrook, Conference Director, Global Engage Ltd. [email protected] +44 (0) 1865 849841 Day One (cont.) – Thursday, 4th December 13.00-14.00 14.00-14.25 14.25-14.50 14.50-15.15 15.15-15.45 15.45-16.35 Lunch One-to-One Meetings Digital Immunohistochemistry for Tissue-Based Diagnosis and Probing the Tumor Microenvironment with Cloud-Based Computer Research: What Could and Should Be Done? Vision Digital pathology brings a quantification and capacity boost to tissue- Recent studies show a remarkable genomic diversity of cancerous based biomarker testing as well as new quality of the information that tumors and indicate that various trajectories of genetic changes can can be retrieved by computer vision. Most immediate benefits may be lead to the common phenotypic hallmarks of cancer. In fact, cancer expected from digital immunohistochemistry - enabling better might be a disease of microenvironmental opportunity. Our research quantification, reproducibility, and new approaches to study spatial vision is to explore the tumor microenvironment by a series of groundaspects of biomarker expression. To get there, one first needs to breaking quantitative and descriptive tissue characterization methods. develop methodologies to control accuracy of the testing, integrate The methods include probing of whole-slide digitized tissue samples and automate data management workflow. with cloud-based computer vision and multiplexed readout of molecular profiles - all aimed at capturing the biologically relevant information in a spatial context. Computerized tissue morphological analysis and tissue niche-specific molecular profiles are then combined with clinical data for the purpose of a more precise prediction of disease outcome, particularly in cancer. CONFIRMED: Arvydas Laurinavičius, Director, National Pathology Center, Vilnius University Hospital Santariskes Clinics, Lithuania Virtual Double Staining for Optimization and Standardization of Quantitative Immunohistochemistry In immunohistochemistry, digital pathology allows objective and standardized quantitative assessment of biomarkers, but there are many methodological issues. Virtual Double Staining overcomes some of the challenges pathologists face with both pattern recognition and physical double staining. In a collaboration between Nordic Immunohistochemical Quality Control (NordiQC) and Visiopharm, a leader in Quantitative Digital Pathology, applications have been developed for the analysis of proliferation markers in cancers and hormone receptors in breast cancer. These applications may be used in a clinical setting as well as for internal and external quality assurance of immunhistochemical staining. CONFIRMED: Mogens Vyberg, Professor of Clinical Pathology, University of Aalborg, Denmark Is Digital Pathology Ready for Use in Routine Histopathology? This presentation reviews the challenges presented in moving from conventional light microscopes to digital pathology (DP) workstations for routine diagnostic histopathology, the approach taken at UHCW to achieve this, why such a move is worthwhile and what it’s potential is for improving our pathology service in the future. An important aspect of this project has been the validation of DP, i.e. an assessment of how effective pathologists are when using digital images, as opposed to conventional microscopes, in their routine diagnostic reporting. The UHCW project has used existing data on inter and intra observer variability to design a non inferiority study of sufficient power to provide statistically significant results. This is the largest study yet conducted and it’s results are expected to inform the debate on the validity of DP in primary diagnosis globally. The project has also examined the expected return on the investment made, the mechanism for delivering increased efficiency with digital pathology systems, and the potential for improving pathology through the use of digital pathology. CONFIRMED: Johan Lundin, Research Director and Professor of Medical Technology, Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland and Karolinska Institutet, Stockholm, Sweden Has Digital Pathology Become Integrated Standard in Pathology Education or is it its Use Still Exception? Opportunities being offered by using combined methods of digital pathology and traditional pathology in undergraduate, as well as post graduate education of pathology. Obstacles and cost benefit issues of setting and maintaining digital pathology educational sites An overview of current projects and educational material in pathology in EU Our experience and reflection on its certain aspects influencing consequently the quality level of education CONFIRMED: Sanja Stifter, Associate Professor, Department of Pathology, Faculty of Medicine, University of Rijeka, Croatia Application of Pattern Recognition Software on Preclinical and Safety Studies Pattern recognition software with a view to: Hierarchical/tiered workflows and utilisation on preclinical and safety tissues prior to or in conjunction with ‘routine analysis’ Comparison of 4 different pattern recognition software systems in the evaluation of progesterone receptor in breast TMA Current applications and future integrations within the drug discovery process and potential translation to companion algorithms CONFIRMED CONFIRMED: David Snead, Consultant Histopathologist and Clinical Service Lead, Alison Bigley, Associate Principal Scientist, Investigative & Translational Pathology, AstraZeneca, UK Coventry and Warwickshire Pathology Services, UK Solution Provider Presentation Solution Provider Presentation For sponsorship opportunities please contact Steve Hambrook For sponsorship opportunities please contact Steve Hambrook at [email protected] at [email protected] Afternoon Refreshments & Poster Presentation Sessions One-to-One Meetings For more information please contact Steve Hambrook, Conference Director, Global Engage Ltd. [email protected] +44 (0) 1865 849841 Day One (cont.) – Thursday, 4th December 16.35-17.05 Solution Provider Presentation Title to be Confirmed Han van Krieken, Full Professor, Pathology, Radboud University Medical Centre 17.05-17.30 Digital Pathology and the Use in the Clinic and in Research CONFIRMED: Eric Verbeeken, Professor, The Translational Cell and Tissue Research Group, KU Leuven, Belgium 17.30-17.55 17.55-18.20 18.20-19.20 Advanced Image Analysis Bridging Tissue Biomarker Discovery from Experimental to Clinical Studies Digital pathology enables context-related, comprehensive analysis of tissue biomarkers beyond measurements of cell densities and staining intensity. The presentation provides examples for successful implementation of advanced image analysis modules in exploratory and clinical studies, and points out perspectives how this technology will help bridging between the experimental setting under laboratory conditions and the reality of biomarker programs in clinical studies. CONFIRMED: Friedrich Feuerhake, Neuropathologist, Institute of Pathology, Hannover Medical School, Germany Relevance of Digitised Synoptic Reporting in Ovarian Cancer The Synoptic (“Structured” or “Templated”) Reporting constitutes the standard of reporting practice and is best developed in diagnostic pathology of cancers. The mandatory Cancer Protocols (and/or modified) incorporated into the LIS relational database, facilitate access to desired information and improve communication for appropriate cancer management. The gross and microscopic digital images (WSIs, IHC and auxiliary studies) form the diagnostic vs. consultative database for the pathological examination and the further quantitative study. The uniform virtual repository allows easy data extraction for the quality improvement and cancer surveillance by cancer registries. The lecture will provide conclusive information on the synoptic reporting in cancer pathology service; present pilot study on the ovarian carcinoma templated reporting introduced in the MIM (Poland) - its benefits, transient barriers and limitations. Solution Provider Presentation For sponsorship opportunities please contact Steve Hambrook at [email protected] Towards Fully Automated Computer Aided Diagnosis in Pathology Large scale introduction of whole slide imaging is still not a reality in clinical pathology, mainly due to associated high costs. Expectedly, the availability of validated computer aided diagnosis (CAD) algorithms will push the balance to a favorable business case. In this talk, results of our current research on CAD techniques and validation are presented. We successfully developed algorithms applying digital image analysis, to recognize tumor areas, quantify tissue features related to cell nuclei, tissue architecture, relationships between cells of different types en tissue texture. CONFIRMED: Jeroen van der Laak, Assistant Professor in Digital Pathology, Dept of Pathology, Radboud University Nijmegen Medical Centre, The Netherlands Title to be Confirmed CONFIRMED: Rob Goldin, Professor of Liver & GI Pathology, Faculty of Medicine, Department of Medicine, Imperial College London, UK Quantitative IHC Assays for Preclinical Research Decisions in lead optimization stages for our compounds RESERVED: Doug Bowman, Associate Scientific Fellow, Takeda CONFIRMED:: Pharmaceuticals, USA Janina Slodkowska, Department of Pathology, Consultant Specialist, Military Institute of Medicine, Poland Chairman’s Closing Remarks and End of Day 1 Drinks Reception For more information please contact Steve Hambrook, Conference Director, Global Engage Ltd. [email protected] +44 (0) 1865 849841 Agenda: Day Two – Friday, 5th December 2014 08.00-08.40 08.40-09.10 Morning Coffee One-to-One Meetings Stream Chair – Kate Lillard, Chief Scientific Officer, Indica Labs Inc. Keynote Address Standardisation in Digital Pathology Future advances in digital pathology will need to include medical image standardization related to DICOM and HL7 standards. In addition, this will likely involve expansion of the IHE Anatomic Pathology technical frameworks, and SNOMED CT broader use. The main advantage of using the DICOM standard instead of proprietary file formats is to store pathology images in a PACS, like radiologists or cardiologists do. Governance in pathology information technology standards needs active input from national and international pathology associations, in coordination with major international general standardization bodies (e.g. ISO, ITU), and specific standards development groups (e.g. DICOM, HL7, IHE, SNOMED CT). It is important that pathology images can also be incorporated into the patient’s health record. 09.10-09.40 CONFIRMED: Marcial Garcia Rojo, Head of Pathology Department. Hospital de Jerez de la Frontera, Cádiz, Spain Improving WSI Workflow 09.40-10.10 CONFIRMED: Paul van Diest, Head of Department, Professor in Pathology, University Medical Center Utrecht, Netherlands Solution Provider Presentation 10.10-11.20 Morning Refreshments Poster Presentation Sessions Scheduled One-to-One Meetings 11.20-11.45 Variation in Digital Pathology Scanning There are a number of Digital Pathology Vendors on the market offering tile or line-scanning, with a variety of calibration techniques associated with this. The assumption is that every slide will be scanned identically providing reproducible analysis data to the user every time. We have performed a reproducibility study on 3 digital pathology systems before and after re-calibration to examine the inherent variability in the scanning systems and how this variability affects image analysis results. 11.45-12.15 CONFIRMED: Will Howat, Head of Histopathology/ISH, Cancer Research UK Solution Provider Presentation TissueMark: Automated Image Analysis for the Calculation of % Tumour Nuclei in Molecular Pathology Visual estimation of % tumour nuclei shows gross variation between laboratories and between pathologists, potentially resulting in inaccurate molecular testing and patient therapy. Within PathXL’s automated tumour annotation and analysis software TissueMark, we have developed a ‘cell counting calculator’, calculating % tumour nuclei using automated image analysis on H&E digital slides. Validation was performed by comparing automated % tumour nuclear counts using TissueMark technology with manually hand-counted nuclei in a series of breast, lung and colorectal images. There was strong correlation between TissueMarks automated % tumour nuclear calculations and manual nuclear counts across all three tissue types. This represents a novel approach for precisely measuring % tumour cells in tissue samples for molecular evaluation, improving reliability in discovery and diagnostics. CONFIRMED: Peter Hamilton, Vice President for Research and Development, PathXL 12.15-12.45 Panel Discussion – Overcoming Barriers in Adoption of Digital Pathology CONFIRMED: Keith Kaplan, Pathologist, Charlotte, NC, USA Liron Pantanowitz, Associate Professor of Pathology & Biomedical Informatics, Director of the Pathology Informatics Fellowship Program and Associate Director of the Pathology Informatics Division at the University of Pittsburgh Medical Center, USA Paul van Diest, Head of Department, Professor in Pathology, University Medical Center Utrecht, Netherlands Yukako Yagi, Director of the MGH Pathology Imaging & Communication Technology (PICT) Center Massachusetts General Hospital; Affiliated Faculty, Wellman Center for Photomedicine, Massachusetts General Hospital; Assistant Professor of Pathology, Harvard Medical School, USA Marcial Garcia Rojo, Head of Pathology Department. Hospital de Jerez de la Frontera, Cádiz, Spain 12.45-13.45 Toby Cornish, Assistant Professor of Pathology, Division of Gastrointestinal and Liver Pathology, Johns Hopkins School of Medicine, USA Lunch Poster Presentation Sessions Scheduled One-to-One Meetings For more information please contact Steve Hambrook, Conference Director, Global Engage Ltd. [email protected] +44 (0) 1865 849841 Day Two (cont.) – Friday, 5th December 2014 13.45-14.10 14.10-14.35 14.35-15.00 15.00-15.15 15.15-15.45 15.45-16.10 16.10-16.35 16.35-17.00 AngioPath: Morphometric Tool for Vessel Segmentation in Angiogenesis Research Given that angiogenesis and lymph angiogenesis are strongly related to prognosis in neoplastic and other pathologies and that many methods exist for their study providing different results, we aim to construct a morphometric tool allowing quantifying and measuring different aspects of the shape and size of vascular vessels in a complete and accurate way. The developed tool is based on vessel closing which is an essential property to properly count the number and characterize the size and the shape of vascular and lymphatic vessels. The method is fast and accurate improving existing tools for angiogenesis analysis. The tool also improves the accuracy of vascular density measurements, since it considered as a single object the set of endothelial cells forming a vessel. CONFIRMED: Gloria Bueno, Professor, VISILAB – School of Engineering, Universidad de Castilla-La Mancha, Spain Global Insourcing of Pathology Consultation and Second Opinion Using Digital Pathology Outline the opportunities and motivation for developing a global consultation and secondary opinion service Discuss the significant logistical, cultural, political and technical barriers to realizing a global consultation service Describe how digital pathology, in the form of web-based teleconsultation networks, enables a global consultation workflow CONFIRMED: Toby Cornish, Assistant Professor of Pathology, Division of Gastrointestinal and Liver Pathology, Johns Hopkins School of Medicine, USA Digital Image Analysis CONFIRMED: Marielle Odin, Director of Pathology, Roche, Germany Applications of Virtual Microscopy in Routine Pathology Adoption of virtual microscopy in diagnostic histopathology has been rather slow. It appears that simple slide viewing is equally easy with conventional microscope than using a computer monitor. We hypothesize that pathologists could shift to use virtual microscopy when applications where virtual microscopy could better or more efficient become available in an easy-to-use interface. These applications include quick consultation, various length and area measurements, nuclear grading, cell counting, IHC analysis, multiple staining viewing, case comparison, etc. We demonstrate our web-based virtual microscopy software, which includes a large set of useful applications in a simplified virtual microscope user interface. CONFIRMED: Jorma Isola, Professor of Cancer Biology, University of Tampere, BioMediTech, FinlandDigital Image Analysis Afternoon Refreshments Poster Presentation Sessions A Virtual Thymoma Pathology Panel - Living Apart Together Thymic tumours (thymoma and thymic carcinoma) are very rare tumours. Accurate histological subtyping using the WHO scheme and staging are important factors determining prognosis and possible adjuvant treatment. Because of the low incidence and subsequent low exposure to these rare tumours, typing is best performed by experts, preferably in a panel setting. However, panel meetings are constrained by time and place. We formed a Virtual Thymoma panel, using virtual microscopy and a web-based reporting system to provide a diagnostic service to submitting pathologists faced with thymic tumour specimens. The nature of the system released the time and geographic constraints, enabling invitation of international experts to join the panel. Over 100 hundred cases have currently been diagnosed by the panel. CONFIRMED: Michael den Bakker, Consultant Histopathologist Department of Pathology, Maasstad Hospital, The Netherlands Data Mining for Research and Diagnostics Description of our image generation and analysis pathway. The setup is suitable for fast turnaround diagnostics as well as for extensive research programmes. Generation of an algorithm to compare different brain sections to effectively remove mathematically all the curves of the human brain. We will show how to match large numbers of brain sections to compare similarities or difference between dozens or even hundreds of samples. Evaluation of a rapid throughput image analysis for tissue based molecular diagnostics. Examples for biomarker identification: Correlation of imaging and expression analysis data in an experimental models for brain tumours CONFIRMED: Sebastian Brandner, Professor and Chair of Neuropathology, Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, and Dept. of Neurodegenerative Disease, UCL Institute of Neurology, UK Colorimetric Detection of Prostate Cancer in Grid Regions Utilizing a Ratio of Racemase to High Molecular Weight Keratin (HMWK) and P63 CONFIRMED: Stephen Schmechel, Associate Professor, Chief of Pathology (Acting), Harborview Medical Center, Department of Pathology, University of Washington School of Medicine, USA Chairman’s Closing Remarks and Conference Close For more information please contact Steve Hambrook, Conference Director, Global Engage Ltd. [email protected] +44 (0) 1865 849841 Digital Pathology Congress – 4-5 December 2014, London, UK How To Register QR: Phone: +44 (0) 1865 849841 Fax: +44 (0) 1865 598989 Email: [email protected] Web: www.globalengage.co.uk/digital-pathology.html Mail: Global Engage, Suite B, The Kidlington Centre, Kidlington, Oxfordshire, OX5 2DL United Kingdom Delegate One Two Three (this place is free) Mr, Mrs, Ms, Dr, Prof: First Name Family Name Position Email Contact Organization Address Cell: Tel: Email: Conference Fees Industry Delegate Academic Delegate Solution Provider Attendee £795 + vat £495 + vat £1295 + vat Discount Code: Discount Code: Discount Code: Payment Details Total: £ Cheques should be made out to: Global Engage Ltd. 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