LEADERS IN ONCOLOGIC INTERVENTIONS ECIO 2015 Sixth European Conference on Interventional Oncology April 22-25, 2015 Nice, France PRELIMINARY PROGRAMME www.ecio.org C RSE Cardiovascular and Interventional Radiological Society of Europe LE AD E R S I N O N CO LO G I C ECIO is now well established as an annual event, and the interest shown and the feedback received have demonstrated that the move to an annual format was a wise one. The field of interventional oncology is growing rapidly, and ECIO offers a structured space in which practitioners can stay abreast of the latest developments and learn new techniques. Oncology is a field that requires inter-disciplinary collaboration. Patients now benefit from a vast array of specialist knowledge, but this brings its own challenges, and ECIO is striving to ensure its educational programme reflects and supports a A. Adam C. Ayuso A.-M. Belli P. Chevallier collaborative approach. This includes working with diverse partner societies on a variety of joint sessions, and we are delighted that such sessions will again be offered. The president of the Japanese Society of Interventional Radiology, which has been strongly focused on interventional oncology for many years, will be delivering this year’s Honorary Lecture. Dr. Yasuaki Arai, who has been at the forefront of the discipline in the Asia-Pacific, will be giving a speech entitled Beyond the evidence – the true goal of interventional oncology. T. de Baère A. Denys A. Gangi J.-F.H. Geschwind COMMITTEES Advisory Board Scientific Programme Committee Local Host Committee Andreas Adam (UK) Thierry de Baère (FR) Johannes Lammer (AT) Riccardo Lencioni (IT) Jan H. Peregrin (CZ) Jim A. Reekers (NL) Thierry de Baère (FR), Chairperson Thomas K. Helmberger (DE), Deputy Chairperson Carmen Ayuso (ES) Anna-Maria Belli (UK) Patrick Chevallier (FR) Alban Denys (CH) Afshin Gangi (FR) Jean-François H. Geschwind (US) Patrick Haage (DE) Robert A. Morgan (UK) Franco Orsi (IT) Philippe L. Pereira (DE) Patrick Chevallier (Nice), Chairperson Guillaume Baudin (Nice) Sébastien Bommart (Montpellier) Pascal Chabrot (Clermont-Ferrand) Afshin Gangi (Strasbourg) Jean-Yves Gaubert (Marseille) Boris Guiu (Montpellier) Hicham Kobeiter (Créteil) Sébastien Novellas (Nice) Frank Pilleul (Lyon) Hervé Trillaud (Bordeaux) Vincent Vidal (Marseille) I NTE RV E NTI O N S The meeting has grown over the years, and now encompasses a wide range of session formats, which cater to all styles of learning. The Video Learning Sessions, whose debut in 2014 was well received, will be featured again this year, addressing liver, kidney and lung cancer, as well as the important topic of pain management. Clinical management is an essential pre-requisite for offering a robust interventional oncology service. To support interdisciplinary collaborations and negotiations, a number of Multidisciplinary Tumour Boards will be held, discussing various liver and lung cancer cases. Alongside a wide range of technical advances, ECIO 2015 will cover both established and experimental applications, such as musculoskeletal tumours, lung metastases, and thyroid, adrenal and prostate lesions. The Mediterranean city of Nice offers an excellent location for the congress. Located within driving distance of Italy, Switzerland and Spain, the city’s fame as a beauty spot also translates into a multitude of flight connections. We look forward to welcoming you to Nice! On se retrouve à Nice! P. Haage T.K. Helmberger J. Lammer R. Lencioni R.A. Morgan F. Orsi J.H. Peregrin P.L. Pereira Content 2 3 4 5 6-7 8-20 22 23 24 Preliminary Faculty Honorary Lecture Incentive Programme 6 years of ECIO – 6 reasons to attend Programme Overview Scientific Programme Hands-on Workshops Registration / CME / Important Addresses Accommodation / City Map J.A. Reekers 2 Preliminary Faculty European Conference on Interventional Oncology Preliminary Faculty as per printing date – subject to change Amoretti N. Nice/FR Krokidis M. Cambridge/UK Anderson C. London/UK Lencioni R. Pisa/IT Anty R. Nice/FR Lewandowski R.J. Chicago, IL/US Arai Y. Tokyo/JP Littrup P.J. Detroit, MI/US Arnold D. Freiburg/DE Mahnken A.H.Marburg/DE Ayuso C. Barcelona/ES Majno P. Geneva/CH Baek J.H. Seoul/KR Malagari K. Athens/GR Bezzi M. Rome/IT Malek N.P. Tübingen/DE Bilbao J.I. Pamplona/ES Manca A. Candiolo/IT Bize P.E. Lausanne/CH Marquette C. Nice/FR Breen D.J. Southampton/UK McCrone P. London/UK Callstrom M.R. Rochester, MN/US Mindjuk I. Dachau/DE Caridi J.G. New Orleans, LA/US Miyayama S. Fukui/JP Carrafiello G. Varese/IT Monfardini L. Milan/IT Chevallier P. Nice/FR Napoli A. Rome/IT Clasen S.R. Tübingen/DE Narayanan G. Miami, FL/US Cornelis F. Bordeaux/FR Orsi F. Milan/IT Crocetti L. Pisa/IT Palussière J. Bordeaux/FR de Baère T. Villejuif/FR Paradis V. Clichy/FR den Brok M. Nijmegen/NL Pelage J.-P. Caen/FR Denys A. Lausanne/CH Pereira P.L. Heilbronn/DE Deschamps F.Villejuif/FR Ricke J. Magdeburg/DE Dupuy D.E. Providence, RI/US Rilling W.S. Milwaukee, WI/US Duran R. Lausanne/CH Ronot M. Clichy/FR Faivre S. Lausanne/CH Ryan A.G. Waterford City/IE François E. Nice/FR Sabharwal T. London/UK Gangi A. Strasbourg/FR Salem R. Chicago, IL/US Garcia-Mónaco R.D. Buenos Aires/AR Samuels S.L. Miami, FL/US Garnon J. Strasbourg/FR Sangro B. Pamplona/ES Gervais D. Boston, MA/US Sofocleous C.T. New York, NY/US Geschwind J.-F.H. Baltimore, MD/US Sommer C.M. Heidelberg/DE Gillams A. London/UK Suh R.D. Los Angeles, CA/US Goldberg N. Jerusalem/IL Tanaka T. Kashihara/JP Guiu B. Montpellier/FR Tapping C. Oxford/UK Helmberger T.K. Munich/DE Tsoumakidou G. Strasbourg/FR Inaba Y. Nagoya/JP Wood B.J. Bethesda, MD/US Jereczek-Fossa B. Milan/IT Woodrum D.A. Rochester, MN/US Kelekis A.D. Athens/GR Yamakado K. Tsu/JP Kenny L.M. Brisbane/AU Zech C.J. Basel/CH Preliminary Programme 3 ECIO 2015 ECIO 2015 Honorary Lecture Yasuaki Arai Yasuaki Arai is Director of, and Chief of the Department of Diagnostic Radiology at, the National Cancer Center Hospital in Tokyo. He also currently serves as the President of the Japanese Society of Interventional Radiology (JSIR). During his residency in internal medicine, Dr. Arai became interested in chemotherapy, and pursued the path of becoming a “medical oncologist”, a term that was not yet particularly well-recognised at the time. He was not satisfied with the clinical results achieved with systemic chemotherapy, and so began exploring the possibility of using a different approach. This ultimately resulted in the invention of an implantable port system, as well as the development of a technique involving placing a catheter via the left subclavian artery for hepatic arterial infusion chemotherapy, a concept first addressed in a publication in a Japanese medical journal in 1983. A year later, Dr. Arai shifted direction, focusing on intervention al radiology at the Aichi Cancer Center, where he practiced for 20 years. Many younger radiologists have joined this institute over the years in order to receive training in interventional radiology. Dr. Arai founded the Japanese Society of Implantable PortAssisted Regional Treatment in 1986, aiming to facilitate the nationwide sharing of knowledge about interventional radiology and the role the specific technique could play in treating cancer. He has led the society, which provides a forum for specialists to exchange information across departments, ever since. The im plantable port system was ultimately introduced in the article entitled “Management of patients with unresectable metastases from colorectal and gastric cancer employing an implantable port system” (Cancer Chemother. Pharmacol. 31:S990102. 1992). Dr. Arai has pursued the development of new IR devices and techniques in order to offer better treatment options throughout his entire career. In addition to his work on the implantable port system and the hepatic arterial chemotherapy technique, in 1992, he collaborated with Toshiba Medical Systems Corporation to develop the prototype of a diagnostic system, consisting of a fluoroscopy and a CT scanner, which is currently well-known as the Angio-CT suite. Furthermore, he has devised various approaches that apply interventional radiological tech niques for palliative care purposes, including using a trans-jugular trans-hepatic peritoneovenous shunt for the management of refractory ascites; embolisation of various tracts and fistula; the percutaneous creation of bilio-intestinal anastomosis; and the creation of an extra-anatomic splenoportal for bleeding ectopic varices. Their application in palliative care stemmed from his 20 years of experience at the Aichi Cancer Center, where he treated thousands of patients suffering from progressive cancer. Strengthening interventional radiology’s evidence base has been another major priority for Dr. Arai during the past 20 years. In 2002, he set up the Japan Interventional Radiology in Onco logy Study Group (JIVROSG) in order to facilitate pursuing evi dence on interventional oncology. Twenty-six clinical studies have been conducted so far, and JIVROSG has published articles on some of these studies, including one entitled “Prospective study of transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma: an Asian cooperative study between Japan and Korea” (J Vasc Interv Radiol. 24: 490-500, 2013). JIVROSG has set itself the challenge of conducting randomised trials that compare interventional radiological procedures to the best treatments available for palliative care. Yasuaki Arai has been an associate editor for the Journal of Vascular and Interventional Radiology, the Cardiovascular and Interventional Radiology Asia-Pacific Journal of Clinical Oncology, and the International Cancer Conference Journal, and has also served as reviewer for several journals. He is a member of several governmental committees in Japan, including for the Ministry of Health, Labour and Welfare and the Pharmaceuticals and Medical Devices Agency. Dr. Arai has been a board member of the Japanese Society of Interventional Radiology for years, helping to establish and expand the reach of interventional radiology in Japan. He is currently its president, and aims to help ensure that interventional radiological procedures become evidence-based, standard treatments, as well as to further IR’s global scope. Since 2004, Dr. Arai has served in the Department of Diagnostic Radiology in the National Cancer Center Japan. Even after leading the institute as the hospital’s director, he remains engaged with the outpatient clinic and with IR procedures. In his spare time, Dr. Arai enjoys mountain climbing and cooking, activities that reflect his preference for tackling challenges with both knowledge and the proper technique. Honorary Lecture Beyond the evidence – the true goal of interventional oncology Thursday, April 23 10:30-11:30 ECIO 2015 Incentive Programme €100,000 Education Grant CIRSE supports the “Referring Physician” programme with €100,000! The ECIO Incentive Programme allows radiologists with a full registration for ECIO 2015 in Nice to invite their referring physician to the conference free of charge. The first 100 referring physicians to sign up will receive free registration and up to €1,000 travel support. For further information and registration please go to www.ecio.org 6 years of ECIO 6 reasons to attend 1 Video Learning Sessions 4 Multidisciplinary Tumour Boards This interactive session format made its debut last year, and due to the hugely positive response received, it has been decided to extend the sessions on offer this year, to cover liver interventions, lung and kidney therapies, and pain management, guiding you through the procedures step by step. Much as they do in the hospital setting, these tumour boards enable participants to actively discuss treatment strategies for specific HCC and lung cancer cases. Guided by the mixed-specialty panel, the audience can vote on optimal therapeutic approaches and discuss the likely outcomes. 2 Best IO Papers 5 Referring Physician Incentive Programme Interventional oncology is a growing field, and both new advances and data supporting existing therapies are of the utmost importance. The Best IO Papers session will round up some of the most interesting research from the past year, providing you with a concise overview of current trends. For many years, the Referring Physician Programme has been enabling interventionists to bring their nonradiologist colleagues to the meeting, where they can see the range of therapies on offer, and the evidence for their use, first-hand. Will you be bringing your colleague to Nice this year? 3 Joint Session with ESMO 6 Nice la Belle To both reflect and enhance the multidisciplinary nature of interventional oncology, joint sessions are held with other medical societies. These provide valuable insights into collaborative possibilities. Our long-time partner, the European Society for Medical Oncology will join us again for a fascinating session on Friday. ‘Nice the Beautiful’ is a wonderful destination for a congress – its picturesque surroundings and mild climate have resulted in the third busiest airport in France, many international train connections, and the second largest hotel capacity in the country. The perfect place for a congress: in hosting ECIO 2015, the city has plenty to inspire not only impressionists, but also interventionists! Wednesday, April 22 Thursday, April 23 30 45 Satellite Symposia 08:00 15 30 45 09:00 15 30 CF 801 Lung metastases CF 101 Early-stage HCC 45 VL 802 How I do it: liver p8 10:00 p12 Coffee break 15 p12 Coffee break 30 45 11:00 15 30 CF 201 Intermediate HCC 45 p8 12:00 HL 901 Honorary Lecture TA-HoW 1 Image-guided tumour ablation – MSK TF 202 Top tips p8 TA-HoW 3 Image-guided tumour p12 ablation – liver p9 PS 902 The best IO papers of 2014 p12 p12 15 30 Lunch break Lunch break 45 13:00 15 30 45 Satellite Symposia Satellite Symposia 14:00 15 30 Break Break 45 15:00 15 30 45 16:00 IS 401 Multidisciplinary Tumour Board: HCC 15 TF 402 Ablation: current status and future horizons p9 30 TA-HoW 2 Image-guided tumour ablation – lung p9 IS 1101 Multidisciplinary Tumour Board: lung p9 p13 Coffee break 45 JS 1102 Essence of interventional oncology Joint session with JSIR TA-HoW 4 Image-guided tumour ablation – kidney p13 p13 Coffee break 17:00 15 30 45 18:00 15 p10 30 45 CF 502 Symptomatic cancer treatment CF 501 How to follow up patients: clinical and imaging CF 1201 Ablation: evidence for expanding the boundaries p10 Satellite Symposia e-voting Preliminary Programme p13 Satellite Symposia 19:00 recommended for EBIR preparation CF 1202 Fundamentals of oncology p14 Friday, April 24 Saturday, April 25 30 45 08:00 Satellite Symposia 15 30 45 09:00 15 30 JS 1502 Colorectal liver metastases ECIO invites ESMO CF 1501 MSK tumours 45 p16 10:00 IS 2101 Management of complications II Coffee break 15 p20 p16 Coffee break 30 45 11:00 15 30 CF 1602 Intra-arterial therapies: what is the evidence? CF 1601 Kidney cancer 45 p16 12:00 VL 2201 How I do it: pain management p16 p20 15 30 Lunch break 45 13:00 15 30 45 Satellite Symposia 14:00 15 30 Break 45 15:00 15 30 45 16:00 VL 1801 How I do it: lung and kidney 15 CF 1802 Quality pays: clinical excellence saves money p17 30 p17 Coffee break 45 17:00 15 30 45 18:00 15 p17 30 45 19:00 JS 1902 Molecular oncology and translation into the clinic Joint session with WCIO IS 1901 Management of complications I Satellite Symposia p18 CF: Clinical Focus Session HL: Honorary Lecture HoW: Hands-on Workshop IS: Interactive Session JS: Joint Session PS: Paper Session TF: Technical Focus Session VL: Video Learning Session 8 Wednesday, April 22 European Conference on Interventional Oncology Wednesday, April 22 08:30-10:00 CF 101 Clinical Focus Session Early-stage HCC 101.1 101.2 101.3 101.4 101.5 Main Auditorium Pathology of early HCC V. Paradis (Clichy/FR) Imaging of early HCC C.J. Zech (Basel/CH) Why and how to biopsy N.P. Malek (Tübingen/DE) What to do when on the waiting list for transplantation P. Majno (Geneva/CH) Evidence from literature: resection vs. ablation for early HCC R. Lencioni (Pisa/IT) 10:30-12:00 CF 201 Clinical Focus Session Intermediate HCC Main Auditorium 201.1 Critical appraisal of EASL vs. Hong Kong classification R. Salem (Chicago, IL/US) 201.2 Where does ablation fit in intermediate stage HCC? P. Chevallier (Nice/FR) 201.3 Drug-eluting beads vs. conventional TACE T.K. Helmberger (Munich/DE) 201.4 Where does radioembolisation fit in intermediate stage HCC? B. Sangro (Pamplona/ES) 201.5 Current evidence of systemic therapy in intermediate stage HCC R. Anty (Nice/FR) 10:30-12:00 TF 202 Technical Focus Session Top tips 202.1 Radioembolisation: preparation A. Denys (Lausanne/CH) 202.2 Radioembolisation: treatment R.J. Lewandowski (Chicago, IL/US) 202.3 DEB TACE J.G. Caridi (New Orleans, LA/US) 202.4 Lung ablation G. Carrafiello (Varese/IT) 202.5 Kidney ablation F. Orsi (Milan/IT) 202.6 Spinal ablation G. Tsoumakidou (Strasbourg/FR) 202.7 Bone consolidation F. Deschamps (Villejuif/FR) Preliminary Programme Auditorium 2 Wednesday, April 22 ECIO 2015 10:30-12:00 TA-HoW 1 Hands-on Workshop Image-guided tumour ablation – MSK 9 HoW Room Co-ordinators: M. Bezzi (Rome/IT), P.L. Pereira (Heilbronn/DE) Instructors: A. Gangi (Strasbourg/FR), A.D. Kelekis (Athens/GR), A. Manca (Candiolo/IT) 13:00-14:30 Satellite Symposia 15:00-16:30 IS 401 Interactive Session Multidisciplinary Tumour Board: HCC Main Auditorium Co-ordinator: R. Lencioni (Pisa/IT) Panellists: R. Anty (Nice/FR), P. Chevallier (Nice/FR), T.K. Helmberger (Munich/DE), P. Majno (Geneva/CH), W.S. Rilling (Milwaukee, WI/US), R. Salem (Chicago, IL/US) 15:00-16:30 TF 402 Technical Focus Session Ablation: current status and future horizons Auditorium 2 402.1 Radiofrequency ablation B.J. Wood (Bethesda, MD/US) 402.2Electroporation N. Goldberg (Jerusalem/IL) 402.3Microwaves P.L. Pereira (Heilbronn/DE) 402.4HIFU I. Mindjuk (Dachau/DE) 402.5Cryoablation D.J. Breen (Southampton/UK) 402.6 Immunomodulation with ablation M. den Brok (Nijmegen/NL) 15:00-16:30 TA-HoW 2 Hands-on Workshop Image-guided tumour ablation – lung Co-ordinators: M. Bezzi (Rome/IT), P.L. Pereira (Heilbronn/DE) Instructors: S.R. Clasen (Tübingen/DE), A. Gillams (London/UK), C.T. Sofocleous (New York, NY/US) e-voting recommended for EBIR preparation HoW Room 10 Wednesday, April 22 17:00-18:30 CF 501 Clinical Focus Session How to follow up patients: clinical and imaging European Conference on Interventional Oncology Main Auditorium 501.1 Radioembolisation for CRC T.K. Helmberger (Munich/DE) 501.2 TACE for HCC J.-F.H. Geschwind (Baltimore, MD/US) 501.3 Ablation of colorectal liver metastases B. Guiu (Montpellier/FR) 501.4 Bone ablation M.R. Callstrom (Rochester, MN/US) 501.5 Ablation of lung metastases J. Ricke (Magdeburg/DE) 17:00-18:30 CF 502 Clinical Focus Session Symptomatic cancer treatment 502.1 Systemic pain medication: a practical guide to be announced 502.2 Evidence-base of radiation therapy for pain L.M. Kenny (Brisbane/AU) 502.3 Nerve blocks G. Tsoumakidou (Strasbourg/FR) 502.4 Percutaneous management of pleural effusion P.E. Bize (Lausanne/CH) 502.5 Percutaneous management of malignant ascites C. Tapping (Oxford/UK) 18:30-19:00 Satellite Symposia Preliminary Programme Auditorium 2 ECIO investigates… Liver Cancer Hepatocellular carcinoma, the most common type of liver cancer, is a growing problem worldwide, due largely to the increasing prevalence of chronic liver disease. Considerable progress with respect to detection, diagnosis, surveillance and treatment has improved outcomes, but HCC is nonetheless the third leading cause of cancer deaths. Relatively few patients are eligible for surgery, and systemic therapy alone is of limited value. Interventional radiology has greatly broadened treatment options, with ablation potentially curative for early-stage HCC. However, most patients still present with intermediate or advanced forms of the disease, meaning palliation plays a predominant role. Early-stage HCC Detection and Diagnosis Early detection and an accurate diagnosis greatly affect a patient’s prognosis. CT and MRI are most commonly used to detect the disease. Thanks to advances in both imaging and surgical techniques, small, early-stage HCCs have increasingly been detected, biopsied, resected and subjected to pathological examinations, helping practitioners better understand their histological features. With imaging techniques enabling more accurate diagnoses, and appreciation of the diagnostic value of contrast washout growing, the need for tissue confirmation has also waned. Intermediate HCC Classifications The Barcelona Clinic Liver Cancer classifications, while widely endorsed, have also long been criticised for providing insufficient options for practitioners confronting intermediate HCC. Now some medical centres are considering adopting the new Hong Kong Liver Cancer classification, and guidelines issued by the European Association for the Study of the Liver and the European Organization for Research and Treatment of Cancer are also receiving much attention. A lecture dedicated to these two approaches will outline their structure and review how they impact daily practice for IRs. Percutaneous Treatment Options Transarterial chemoembolisation remains the standard treatment for intermediate HCC, but most expect the use of drugeluting beads (DEB-TACE) to further improve results. In the meantime, radioembolisation has become an important therapy option, but still faces scepticism regarding its competitive efficacy for HCC beyond the early stage. Treating intermediate HCC with ablation is an even newer concept. Three presentations will closely examine these approaches, presenting results obtained and limitations confronted, including from a comparative perspective. Systemic Therapy Nonetheless, in daily practice, definitive diagnoses often remain challenging, particularly with respect to small nodules. Presentations dedicated to pathology, imaging and biopsies will provide delegates with up-to-date information of pathology in early HCC; outline typical and atypical aspects of the disease on CT and MRI, as well as limitations of the two imaging techniques; and will address when it is still necessary to perform a biopsy. The multi-faceted nature of clinical practice for intermediate HCC includes systemic therapy with drugs, and several ongoing trials are now evaluating the potential of combining such therapy with loco-regional treatments. A presentation on systemic therapies will explore the biological background, outline results achieved, and address at which point such treatments are best combined with IR procedures. Curative Treatment Options Ablation offers a potentially curative option for patients with small localised HCCs. However, critics note that overall, longterm survival rates are higher after resection, and that recurrence remains an issue, while proponents emphasise that it involves fewer complications and shorter hospital stays. In other cases, only liver transplantation is potentially curative, but patients are either ineligible or confronted with a donor shortage. Lectures focusing on ablation, resection and transplantation will outline strategic considerations involved in deciding with which of these approaches to proceed, and scrutinise the strength and weaknesses of both the methods and of studies that seek to compare them. Colorectal liver metastases Practitioners have long emphasised the importance of tailored therapy, but does the concept represent reality or mere hope? A session jointly held with the European Society for Medical Onco logy will consider this important question in the context of colorectal liver metastases, in addition to reviewing other aspects of CRCLM, including the current status of systemic therapy, tumour response following TACE/SIRT, and radioembolisation for palliation. Other sessions A Hands-on Workshop will tackle image-guided tumour ablation in the liver, providing a tangible introduction to the procedure and the devices it involves, and a Video Learning Session will demonstrate how to perform a wide variety of percutaneous liver treatments. 12 Thursday, April 23 European Conference on Interventional Oncology Thursday, April 23 07:45-08:15 Satellite Symposia 08:30-10:00 CF 801 Clinical Focus Session Lung metastases Auditorium 2 801.1 How to evaluate lung function before and after surgery, SBRT and ablation? C. Marquette (Nice/FR) 801.2 Surgery in lung metastases to be announced 801.3 Is ablation of lung metastases a first line therapy? A. Gillams (London/UK) 801.4 Imaging follow-up after treatments: surgery, SBRT, ablation R.D. Suh (Los Angeles, CA/US) 801.5 Evidence from comparative trials for lung metastases L. Monfardini (Milan/IT) 08:30-10:00 VL 802 Video Learning Session How I do it: liver Main Auditorium 802.1 Liver ablation + venous occlusion T. de Baère (Villejuif/FR) 802.2 Combined cTACE and ablation L. Crocetti (Pisa/IT) 802.3DEB-TACE K. Malagari (Athens/GR) 802.4Y-90 J.I. Bilbao (Pamplona/ES) 802.5PVE P.E. Bize (Lausanne/CH) 10:30-11:30 HL 901 Honorary Lecture Main Auditorium Laudation: T. de Baère (Villejuif/FR) 901.1 Beyond the evidence – the true goal of interventional oncology Y. Arai (Tokyo/JP) 11:30-12:00 PS 902 Paper Session The best IO papers of 2014 Main Auditorium 10:30-12:00 TA-HoW 3 Hands-on Workshop Image-guided tumour ablation – liver HoW Room Co-ordinators: M. Bezzi (Rome/IT), P.L. Pereira (Heilbronn/DE) Instructors: L. Crocetti (Pisa/IT), A.H. Mahnken (Marburg/DE), F. Orsi (Milan/IT) Preliminary Programme Thursday, April 23 ECIO 2015 13 13:00-14:30 Satellite Symposia 15:00-16:30 IS 1101 Interactive Session Multidisciplinary Tumour Board: lung Auditorium 2 Co-ordinator: A. Gillams (London/UK) Panellists: M. Bezzi (Rome/IT), L. Monfardini (Milan/IT), S.L. Samuels (Miami, FL/US), R.D. Suh (Los Angeles, CA/US) 15:00-16:30 JS 1102 Joint Session Essence of interventional oncology Joint session with the Japanese Society of Interventional Radiology (JSIR) Main Auditorium 1102.1 Concept of TACE based on micro-vasculature of HCC S. Miyayama (Fukui/JP) 1102.2 Intra-arterial infusion therapy – background and challenges T. Tanaka (Kashihara/JP) 1102.3 Interventional palliative treatment Y. Inaba (Nagoya/JP) 1102.4 Ablation – combination with other IR techniques K. Yamakado (Tsu/JP) 1102.5 Clinical trials for evidences of IO Y. Arai (Tokyo/JP) 15:00-16:30 TA-HoW 4 Hands-on Workshop Image-guided tumour ablation – kidney HoW Room Co-ordinators: M. Bezzi (Rome/IT), P.L. Pereira (Heilbronn/DE) Instructors: D.J. Breen (Southampton/UK), C.M. Sommer (Heidelberg/DE) 17:00-18:30 CF 1201 Clinical Focus Session Ablation: evidence for expanding the boundaries 1201.1Thyroid J.H. Baek (Seoul/KR) 1201.2Breast J. Palussière (Bordeaux/FR) 1201.3Adrenal D.E. Dupuy (Providence, RI/US) 1201.4Lymphnodes A. Gillams (London/UK) 1201.5Prostate D.A. Woodrum (Rochester, MN/US) e-voting recommended for EBIR preparation Main Auditorium 14 Thursday, April 23 European Conference on Interventional Oncology 17:00-18:30 CF 1202 Clinical Focus Session Fundamentals of oncology 1202.1 Conventional chemotherapy D. Arnold (Freiburg/DE) 1202.2 Targeted therapy: what an interventional oncologist should know S. Faivre (Lausanne/CH) 1202.3 Phase I, II, III trials: do you really know the differences? E. François (Nice/FR) 1202.4 How to define response in interventional oncology trials M. Ronot (Clichy/FR) 1202.5 How endpoints in interventional oncology may differ from medical oncology trials R. Salem (Chicago, IL/US) 18:30-19:00 Satellite Symposia Preliminary Programme Auditorium 2 ECIO investigates… Lung Cancer In recent years, ECIO has witnessed an increase in the number of speakers and sessions addressing pulmonary cancers, both primary and metastatic. This is clearly a growing area of interest for practitioners of interventional oncology, and as the pool of case reports grows, so the indications for its use are growing ever clearer. lung metastases, and is achieved by selective embolisation of the branches of the pulmonary artery. Friday’s Clinical Focus Session on Intra-arterial therapies: what is the evidence? will examine the current data for its use in the pulmonary setting and others. This year’s congress will feature a number of sessions presenting this data, and offering valuable advice on patient selection and optimal delivery. These will cover a range of therapeutic applications, including thermal ablation, mechanical ablation and embolisation. Multidisciplinary decision-making Clearly, for both metastatic and primary disease, much more research is needed. Even when clearer indications are eventually defined, each individual patient will still present with a unique set of circumstances and determining the optimal therapy (or therapy combination) is best done in a multidisciplinary setting. Lung metastases Currently, the main clinical areas of investigation for imageguided lung therapies are stage I non-small cell lung cancer (NSCLC) and pulmonary metastases. The latter are a particularly important area of investigation, as they are among the most frequently occurring metastases and are found in approximately 50% of autopsy patients. Metastatic lesions, by their very nature, are often small and multi-nodular, posing challenges for surgical resection. Two promising alternatives for pulmonary metastases are ablation and stereotactic body radiation therapy (SBRT), and these will be examined more closely in Thursday’s Lung metastases Clinical Focus Session. SBRT is an extra-cranial radiation therapy which is delivered in a single or small number of fractions. It is highly precise, and offers the possibility of controlling for target motion. Despite its advantages, there remain some limitations regarding the uncertainty of target definition, dose escalations and inaccurate patient positioning. No clinical trials have yet been completed, and further investigation is needed. Likewise, the evidence supporting ablation is far from complete, but early data indicates that it entails few complications, has short recovery times and is repeatable. Most importantly of all, the literature has demonstrated no deterioration of pulmonary function, which is an important consideration in both the curative and palliative setting. Ensuring clear margins remains a challenge, although using a thermocouple can improve outcomes. The latest evidence for both therapies, and technical advice of evaluating lung function and performing adequate follow-up, will be discussed in this Clinical Focus Session, as well as in the dedicated How to follow up patients: clinical and imaging session taking place on Wednesday. However, ablative techniques are not the only IR procedure available, and preliminary studies into the palliative use of intra-arterial techniques have shown promise. This is mainly used for symptomatic control of bleeding in patients with To demonstrate and encourage this process, a Multidisciplinary Tumour Board session will be devoted to examining lung cancer cases. Practitioners from a range of specialties will be represented, and the session will undoubtedly be informative for all involved in this field. Complications Ablative therapies are not without risk, and it is essential that practitioners are aware of possible complications, and how to deal with them. Pneumothorax is the most common complication, but is easily managed with quiet respiration, and adequate pain control and sedation. The second most frequent complication is pleural effusion, which will be explicitly addressed in Wednesday’s Symptomatic cancer treatment session. Generally, exercising due caution will prevent this occurring, but if faced with pleural effusion, methods such as observation, thoracentesis and pleural catheter placement can be employed. Pain is managed with anti-inflammatory agents, narcotics, anti-convulsant drugs, intercostal nerve block, and hot or cold packs; those wishing to learn more about this topic should attend Saturday’s Video Learning Session, How I do it: pain management, for step-by-step guidance through the use of the PleurX system. Pseudo-aneurysms and delayed acute haemoptysis are very rare and cavitation can occur in large ablations, but does not necessarily indicate infection. A detailed discussion of all lung ablation complications will be given by noted expert Robert Suh, in Saturday’s interactive session, Management of complications II. The full spectrum The programme for this year’s ECIO will cover the full spectrum of image-guided therapies for pulmonary cancers, from patient selection to follow-up. Various ablation modalities will be discussed in a variety of settings, with a Hands-on Workshop on Image-guided tumour ablation – lung giving participants an opportunity to familiarise themselves with a number of devices, and a Video Learning Session guiding attendees through pulmonary cryoablation. 16 Friday, April 24 European Conference on Interventional Oncology Friday, April 24 07:45-08:15 Satellite Symposia 08:30-10:00 CF 1501 Clinical Focus Session MSK tumours Auditorium 2 1501.1 Evidence for ablation in local control M.R. Callstrom (Rochester, MN/US) 1501.2 Evidence for radiation therapy in local control B. Jereczek-Fossa (Milan/IT) 1501.3 When does HIFU fit in? A. Napoli (Rome/IT) 1501.4 Bone consolidation: cementoplasty vs. osteosynthesis F. Deschamps (Villejuif/FR) 1501.5 When to use embolisation in combination with ablation A.G. Ryan (Waterford City/IE) 08:30-10:00 JS 1502 Joint Session Colorectal liver metastases ECIO invites the European Society for Medical Oncology (ESMO) Programme to be announced. 10:30-12:00 CF 1601 Clinical Focus Session Kidney cancer Main Auditorium Main Auditorium 1601.1 Renal mass: surveillance protocols, indications for biopsy and thresholds for treatment to be announced 1601.2 Evidence-based nephron-sparing surgery C. Anderson (London/UK) 1601.3 Evidence-based ablation vs. resection outcomes D.J. Breen (Southampton/UK) 1601.4 Systemic and adjuvant treatment in RCC to be announced 1601.5 Follow-up after ablation: imaging and clinical D. Gervais (Boston, MA/US) 10:30-12:00 CF 1602 Clinical Focus Session Intra-arterial therapies: what is the evidence? 1602.1 Liver metastases from melanoma: what is the role of intra-arterial therapies today? P.L. Pereira (Heilbronn/DE) 1602.2 Neuroendocrine liver metastases: which intra-arterial therapy for which patient? B. Guiu (Montpellier/FR) 1602.3 Intra-arterial therapy in lung tumours: where do we stand? J.-P. Pelage (Caen/FR) 1602.4 Cholangiolar carcinoma: the relative role of TACE vs. systemic therapy W.S. Rilling (Milwaukee, WI/US) 1602.5 Intra-arterial therapy in liver metastases: the 5 best papers of the past year R.D. Garcia-Mónaco (Buenos Aires/AR) Auditorium 2 Friday, April 24 ECIO 2015 17 13:00-14:30 Satellite Symposia 15:00-16:30 VL 1801 Video Learning Session How I do it: lung and kidney Main Auditorium 1801.1 Lung RFA/MWA D.E. Dupuy (Providence, RI/US) 1801.2 Lung cryoablation P.J. Littrup (Detroit, MI/US) 1801.3 Kidney RFA/MWA F. Cornelis (Bordeaux/FR) 1801.4 Kidney cryoablation D.J. Breen (Southampton/UK) 1801.5 Percutaneous pancreas IRE G. Narayanan (Miami, FL/US) 15:00-16:30 CF 1802 Clinical Focus Session Quality pays: clinical excellence saves money Auditorium 2 1802.1 Improve quality without added cost: patient pathway in IO A. Denys (Lausanne/CH) 1802.2 Improve quality without added cost: a structured IO report A. Gangi (Strasbourg/FR) 1802.3 Cost effectiveness in patient care: what is it, and how to measure it in interventional oncology? P. McCrone (London/UK) 1802.4 Disinvestment in medicine, and the need for evidence L.M. Kenny (Brisbane/AU) 1802.5 The science underpinning interventional oncology: how should we prove the value of what we do? R. Lencioni (Pisa/IT) 17:00-18:30 IS 1901 Interactive Session Management of complications I 1901.1 Liver TACE S.L. Samuels (Miami, FL/US) 1901.2 Liver ablation P. Chevallier (Nice/FR) 1901.3Radioembolisation A.H. Mahnken (Marburg/DE) 1901.4 GI complications T. Sabharwal (London/UK) e-voting recommended for EBIR preparation Main Auditorium 18 Friday, April 24 European Conference on Interventional Oncology 17:00-18:30 JS 1902 Joint Session Molecular oncology and translation into the clinic Joint session with the World Conference on Interventional Oncology (WCIO) 1902.1 Oncogenic pathways and their relevance to interventional oncology N. Goldberg (Jerusalem/IL) 1902.2 Tumour hypoxia B.J. Wood (Bethesda, MD/US) 1902.3 Immunomodulation and radioembolisation J. Ricke (Magdeburg/DE) 1902.4 Tumour metabolism J.-F.H. Geschwind (Baltimore, MD/US) 1902.5 Image-guided drug activation R. Duran (Lausanne/CH) 1902.6 DNA repair inhibitor A. Denys (Lausanne/CH) 18:30-19:00 Satellite Symposia Preliminary Programme Auditorium 2 ECIO investigates… MSK tumours Interventional radiological treatment of tumours in solid organs, such as primary or secondary liver tumours or renal cell carcinoma (RCC) is already well established, or has at least gained major attention in interdisciplinary discussions. Moreover, interventional radiology is well established in the musculoskeletal (MSK) field, mainly in the fields of pain management (e.g. perineural or facet joint infiltration), but a wide range of tumour-related interventions are also well accepted. Primary MSK cancers are comparatively rare, but bone metastases, which can derive from any type of primary cancer but occur frequently in prostate, breast and lung cancer patients, are quite common. Furthermore, there are a substantial number of benign tumours, such as osteoid osteoma and osteoblastoma, typically occurring in patients aged between 5 and 25 years, or rarer benign tumours, such as desmoid tumours and haemangiomas, which may present a more aggressive growth pattern. Interventional radiology can be performed for curative or palliative/symptomatic treatment in functionally stable or unstable, benign or malignant tumours. Furthermore, in many cases interventional therapy offers local tumour control (e.g. by thermal destruction), minimisation of fracture risks by stabilisation (e.g. by cementoplasty) together with pain therapy (e.g. destruction of nociceptors). In general, all these interventional techniques can be used in combination with other therapies (e.g. chemotherapy, radiation therapy or surgery), but can also offer the possibility of symptom relief where other therapies have failed. Thermal ablation Thermal ablative techniques, in particular radiofrequency ablation (RFA), are the method of choice for benign lesions such as osteoid osteoma and many haemangiomas (mostly vertebral localisation), but are also applied for destruction in malignant tumours. The extensive experience in applying RFA to bone tumours confirms RFA as an easy and safe technique in many different skeletal localisations with a low risk of complications. The database for other thermal ablative techniques (microwave ablation, cryoablation, HIFU or laser) is still very limited and is often only single-centre-based, and more data is needed to establish the clinical value of each of these techniques. Transvascular techniques Transarterial tumour embolisation in hypervascularised tumours (e.g. bone metastasis from RCC) is used to make another therapy easier (e.g. for reducing blood loss during surgery) or for debulking in large symptomatic tumours where other therapies have failed or are not amenable. Augmentation therapies Musculoskeletal tumours, whether primary or metastatic, can often compromise the structural integrity of the affected bone. Whether this occurs due to invasion and displacement of the healthy tissue, or as a result of therapeutic intervention, stabilising the bone is important for both patient mobility and resolution of potential pain. A number of percutaneous approaches are currently used, ranging from cementoplasty to the image-guided percutaneous placement of screws or pins (osteosynthesis), or frequently, a combination of the two. As with thermal ablative procedures, knowledge of the local anatomy and real-time monitoring is essential to avoid complications. This important topic will be addressed in Wednesday’s Top tips session, where speakers will address both spinal ablation and bone consolidation, along with other therapies of growing interest. Pain therapy/management Beside thermal ablation of osteoid osteomas, which can be very painful, most MSK interventional procedures need no specific pain management and can be performed under local anaesthesia or mild analgo-sedation. It can be even crucial to get the immediate feedback from the patient with respect to pain to avoid serious complications. Nevertheless, interventional therapy of many painful MSK lesions results in immediate pain relief – almost “on the table”. Risks and complications Local interventional therapy in MSK structures is straightforward in most cases. Nevertheless, in some cases interdisciplinary assistance is mandatory to get the right access to a specific lesion (e.g. by mechanical bone drill). The procedure can also be challenging due to the close anatomical proximity of crucial structures (e.g. nerve structures) necessitating special techniques for cooling (e.g. perfusion with a coolant, skin cooling pads) or dislodgement (e.g. hydrodissection). MSK programme at ECIO 2015 To ensure comprehensive educational opportunities, the ECIO 2015 programme will be covering MSK tumour therapies in a range of session formats. A Hands-on Workshop, Clinical Focus Sessions, Interactive Sessions and even a Video Learning Session will guide delegates through both the theory and the practice of a range of treatments. Most importantly of all, the evidence for their use will be examined alongside radiotherapeutic and surgical options, equipping those practicing MSK interventions with the skills needed to be clinically involved in their hospital’s tumour boards. 20 Saturday, April 25 European Conference on Interventional Oncology Saturday, April 25 08:30-10:00 IS 2101 Interactive Session Management of complications II Main Auditorium 2101.1 MSK tumour management A. Gangi (Strasbourg/FR) 2101.2 Liver ablation C. Ayuso (Barcelona/ES) 2101.3 Kidney ablation M. Krokidis (Cambridge/UK) 2101.4 Lung ablation R.D. Suh (Los Angeles, CA/US) 10:30-12:00 VL 2201 Video Learning Session How I do it: pain management 2201.1 Splanchnic neurolysis A.D. Kelekis (Athens/GR) 2201.2 Vertebroplasty and ablation J. Garnon (Strasbourg/FR) 2201.3PleurX G. Narayanan (Miami, FL/US) 2201.4 Pelvic osteosynthesis N. Amoretti (Nice/FR) 2201.5 Hypogastric neurolysis to be announced Preliminary Programme Main Auditorium EBI R European Board of Interventional Radiology Special preparation courses for the EBIR The EBIR is a highly valuable qualification in interventional radiology, based on the European Curriculum and Syllabus for IR. Sessions especially suited for EBIR preparation are highlighted in the ECIO 2015 Scientific Programme (pages 6-20). Apply for the 2015 EBIR examinations now online! For detailed information regarding examination dates and entry criteria, please visit our website at www.cirse.org/ebir Certify your expertise! European Board of Interventional Radiology c/o CIRSE Neutorgasse 9, 1010 Vienna, Austria [email protected] www.cirse.org/ebir C RSE 22 Hands-on Workshops European Conference on Interventional Oncology Image-guided tumour ablation Co-ordinators: M. Bezzi (Rome/IT), P.L. Pereira (Heilbronn/DE) Image courtesy of Prof. Laura Crocetti This hands-on workshop will give you the opportunity to participate in interactive sessions based on case presentations. Four workshops will each target a specific organ (MSK, lung, liver and kidney). The cases are presented by leading ablation experts with many years of experience in an informal inter active setting allowing for questions and discussion. A range of different ablation systems (RFA, cryotherapy and microwave ablation) and some image guidance technology will be accessible to the participants during the sessions for ex-vivo demonstrations. Learning objectives – To learn how to handle different energy sources and the respective equipment for tumour ablation – To obtain a good understanding of the range of available ablation techniques and their proper clinical application – To learn what factors are predictive of success and failure in order to determine the best indication and optimal combination of therapies – To understand the main reported complications of ablation and the basics of preventing and managing them – To learn about “tips and tricks” with the use of clinical cases – To generally learn about the indications of other medical and surgical treatments TA-HoW 1 Wednesday, April 22 MSK10:30-12:00 Instructors: A. Gangi (Strasbourg/FR), A.D. Kelekis (Athens/GR), A. Manca (Candiolo/IT) TA-HoW 2 Wednesday, April 22 Lung15:00-16:30 Instructors: S.R. Clasen (Tübingen/DE), A. Gillams (London/UK), C.T. Sofocleous (New York, NY/US) TA-HoW 3 Thursday, April 23 Liver10:30-12:00 Instructors: L. Crocetti (Pisa/IT), A.H. Mahnken (Marburg/DE), F. Orsi (Milan/IT) TA-HoW 4 Thursday, April 23 Kidney15:00-16:30 Instructors: D.J. Breen (Southampton/UK), C.M. Sommer (Heidelberg/DE) Location HoW Room Please note that participants need to register in advance at an extra cost of €75. Preliminary Programme Registration / CME / Important Addresses ECIO 2015 Registration Online registration (secured payment) for ECIO 2015 is available at www.ecio.org. Please note that your registration must be submitted and full payment needs to be received by the respective registration deadlines. Otherwise the respective next higher fee shall be due. Furthermore please be advised that incomplete registrations (not containing full name, e-mail and address) cannot be processed. Registration Fees Early – until January 22, 2015 (23:59 CET) CIRSE Member Non-Member Resident / Nurse / Radiographer* Undergraduate Medical Student** €390 €590 €250 € 0 Until February 19, 2015 (23:59 CET) CIRSE Member Non-Member Resident / Nurse / Radiographer* Undergraduate Medical Student** €550 €790 €385 € 0 After February 19, 2015 CIRSE Member Non-Member Resident / Nurse / Radiographer* Undergraduate Medical Student** €750 €860 €420 € 0 * To be accompanied by a certificate, signed by the head of department. ** Registration needs to be accompanied by a confirmation of student status at the time of congress, a one page CV and a copy of a valid photo ID. Registration fees inclusive of 20% VAT Under French Fiscal Regulations, VAT (20%) is charged on invoices to all customers who do NOT have a valid French VAT number. This applies to customers based in all countries inside and outside the EU. Only if a valid French VAT number is provided, VAT is not charged. For all customers who do have a valid French VAT number: Opération bénéficiant du régime d’auto-liquidation prévu par l’article 283-1 du CGI; TVA due par le client. Reduced CIRSE Member registration is only available for members of CIRSE (Cardiovascular and Interventional Radiological Society of Europe) in good standing. Method of payment Registration fees are to be paid in Euros (€) by: - Bank transfer or Credit Card (Visa or Mastercard) Subscription to ESIRonline We are extending year-round ESIRonline access to non-members: purchase your one-year subscription for ESIRonline (www.esir.org), for only €30 together with your registration to ECIO 2015.* Cancellation of congress registration CIRSE GmbH offers all pre-registered participants the possibili ty to take out cancellation insurance with its partner „Europäi sche Reiseversicherung“. The insurance can only be booked during and until finalisation of the online registration process. The refund of the participant‘s registration fee due to cancellation of the registration or the change of registration category is only possible with a valid insurance. CIRSE GmbH itself will not refund any registration fees. All requests must be made to „Europäische Reiseversicherung“ directly. Refunds will be given according to the terms and conditions of the „Europäische Reiseversicherung“. CIRSE GmbH shall not be responsible for any refunds of registration fees. Name changes will be handled as a cancellation and new registration. Additional information: All ECIO 2015 registrants will be able to print out an invoice of registration using their personal login details at www.ecio.org. Invoices will be issued by: CIRSE Congress Research Education GmbH, Neutorgasse 9, 1010 Vienna, Austria CME Credit Allowance European Accreditation will be applied for at the EACCME (European Accreditation Council for Continuing Medical Education). The EACCME is an institution of the European Union of Medical Specialists (UEMS), www.uems.net. Important Addresses Congress Venue Nice Acropolis Convention Centre 1 Esplanade Kennedy 06300 Nice, France Organising Secretariat CIRSE Central Office Neutorgasse 9 1010 Vienna, Austria Phone: +43 1 904 2003 Fax: +43 1 904 2003 30 E-mail: [email protected] Web: www.ecio.org E-mail Contacts For general enquiries about the ECIO 2015 meeting, please send an e-mail to [email protected]. In case of queries concerning registration for the ECIO 2015 meeting, please send an e-mail to [email protected]. * CIRSE Members in good standing benefit from full access to ESIRonline. For information about the scientific programme of ECIO 2015, please send an e-mail to [email protected]. 23 24 Accommodation / City Map European Conference on Interventional Oncology Accommodation In cooperation with our travel partner Kuoni DMC, CIRSE has secured a great number of hotel rooms in Nice for the benefit of our congress participants. For further information about the official CIRSE hotels and room bookings, please refer to www.ecio.org. If you have any questions, please do not hesitate to contact: Kuoni Destination Management FR Contact: Ms Sophie Veyrier 31 avenue Jean Médecin 06000 Nice, France Phone: +33 1 55 99 98 98 E-mail: [email protected] List of hotels 1 2 3 4 5 6 7 Hotel Category Single Room (€) Double Room (€) Travel Time Public Transport Taxi Negresco Hôtel Beau Rivage Grand Hotel Aston NH Hotel Le Méridien Nice (Classic Room) Le Méridien Nice (Deluxe City View) Novotel Acropolis Ibis Palais des Congrès 5* 4* 4* 4* 4* 4* 4* 3* 274.50 156.50 156.50 161.50 192.50 237.50 147.50 108.00 291.00 168.00 168.00 178.00 210.00 252.00 166.00 119.00 25 min 10 min 5 min 5 min walk 10 min 10 min 4 min walk 9 min walk All rates are in Euros (€), per room, per night, including breakfast and taxes. Nice City Map 6 Acropolis Convention Centre 3 Tram Station “Opéra - Vieille Ville“ 5 1 Preliminary Programme 2 4 Tram Station “Acropolis“ 7 7 min 5 min 5 min 5 min 5 min The European Conference on Interventional Oncology is organised by CIRSE (Cardiovascular and Interventional Radiological Society of Europe). The official congress website is: www.ecio.org To contact the CIRSE Central Office or members of the committee please write to [email protected]. Print kompensiert www.druckmedien.at GraphX by L O O P . E N T E R P R I S E S media www.loop-enterprises.com Preliminary Programme ECIO 2015 In case of any enquiries or comments, please contact us at [email protected] © Cardiovascular and Interventional Radiological Society of Europe / 2014 CIRSE does not accept responsibility for errors or misprints. Preliminary Programme
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