Hollings Cancer Center Research Retreat Agenda 8:15 – 8:30 Continental Breakfast 8:30 – 8:45 J. Alan Diehl, PhD Associate Director of Basic Sciences Welcome 8:45 – 9:45 Professor C. Roland Wolfe, PhD, FRSE, FMedSci, OBE “The application of mouse models humanized for pathways of drug metabolism and stress responses to the development and use of anticancer drugs” 9:45 – 9:50 Kenneth D. Tew, PhD & Carolyn D. Britten, MD Co-Leaders, Development Cancer Therapeutics Program Introduction 9:50 – 10:05 Christopher Xiao, Pre-doctoral Student Mentor: Dr. Terry Day “Racial disparities in head and neck squamous cell cancer survival: The C.A.S.E. Study” 10:05 – 10:20 Zhi-wei Ye, PhD, Post-doctoral Trainee Mentors: Drs. Danyelle Townsend & Ken Tew “Glutathione S-Transferase P (GSTP) mediated protein S-Glutathionylation regulates endoplasmic reticulum (ER) stress and the unfolded protein response” 10:20 – 10:35 Ryan De Palma, Pre-doctoral Student Faculty Mentor: Dr. Besim Ogretmen “Regulation of tumor suppressor PP2A and its inhibitor SET oncoprotein interaction by sphingolipids” 10:35 – 10:40 Chanita Hughes-Halbert, PhD Leader, Cancer Control Program Introduction 10:40 – 10:55 S. Lewis Cooper, MD Assistant Professor, Radiation Oncology Mentor: Dr. Katherine Hoover “Standardizing tobacco assessments for patients seen at the Hollings Cancer Center” 10:55 – 11:10 Brett Froeliger, PhD Assistant Professor Neurosciences and Psychiatry “The effects of N-acetylcysteine on corticostriatal circuitry function may help smokers to remain smoke free” 11:10 – 12:10 Poster Session 1 Posters assigned “A” will be reviewed 12:10 – 12:50 Lunch 12:50 – 12:55 Philip Howe, PhD, Interim Leader Cancer Genes & Molecular Regulation Program Introduction 12:55 – 1:10 Dayvia A. Laws, Pre-doctoral Student Faculty Mentor: Dr. Amanda LaRue “Soft tissue sarcoma-determining the role of circulating fibroblast precursors in promoting metastasis” 1:10 – 1:25 Akihiro Yoshida, PhD, Post-doctoral Trainee Faculty Mentor: Dr. Alan Diehl “The efficacy of CDK4/6 inhibition in melanoma” 1:25 – 1:30 Zihai Li, MD, PhD Leader, Cancer Immunology Program Introduction 1:30 – 1:45 Yongxia Wu, Pre-doctoral Student Faculty Mentor: Dr. Xue-Zhong Yu “MicroRNA-17-92 cluster: Novel target for controlling GVHD while preserving GVL effect” 1:45 – 2:00 Melissa Scheiber, PhD, Post-doctoral Trainee Faculty Mentor: Dr. Stephen Tomlinson “Complement dependent modulation of anti-tumor immunity following radiation therapy” 2:00 – 3:00 Poster Session 2 Posters assigned to “B” will be reviewed 3:00 – 4:00 John Condeelis, PhD “Understanding how tumors spread and how to stop them” 4:00 – 4:10 Dennis Watson, PhD Associate Director of Education & Training Presentation of Edith H. Peng Excellence in Research Awards