PHARMACEUTICAL FLOW CYTOMETRY & IMAGING GSK CONFERENCE CENTER, WARE, UK 19 & 20 NOVEMBER 2014 ISC FA CE O FD RU GD HE ED NG GI HA N TH EC PE RS O NA LIS SC PIC OT Y PH EN CH HT TE W NE SA FE TY S/ NO HC S LO G IES RE E NI AL TH NG CA RE OV E RY www.elrig.org Generously sponsored by: Supported and organised by: WELCOME WORDS A very warm welcome to delegates, speakers and exhibitors joining us for the 4th Pharmaceutical Flow Cytometry and Imaging Conference organised by ELRIG. I am especially pleased to be able to welcome you back to the newly named Sir David Jack Centre for Research and Development at GSK Ware, a site steeped in tradition and recognized for its impressive history of developing new and innovative medicines. Building on previous meetings, our exciting 2014 scientific program explores new advances in flow cytometry and high content imaging and their increasing application to academic research and pharmaceutical drug discovery. In recent years, BioPharma R&D has experienced considerable changes in scientific direction with a move towards more relevant phenotypic and human disease systems for drug discovery and lead optimisation. In parallel, therapeutic areas such as oncology and infectious diseases are shifting to more immunologybased disease modulation strategies. Over the next two days, a superb group of world-class speakers will discuss capability development in high content imaging microscopy and flow cytometry technologies and describe how new solutions such as mass cytometry and super resolution imaging are continuing to advance our understanding of cell and pathway function to better connect targets, pathways and disease biology. The scientific program will be complimented by a poster session and vendor exhibition which will allow attendees to explore the latest developments in reagents and instrumentation in this rapidly growing research area. James Pilling (AstraZeneca), Ben Powney (Eisai), Theo Dare (GlaxoSmithKline) and Jennifer Hincks (Huntingdon Life Sciences) together with Dermot Boylan and Liz Quinn from ELRIG for putting together an impressive two day scientific program. ELRIG is a not-for-profit organisation whose main objective is to provide an open communication forum for member education and networking. They are particularly proud to be able to provide free delegate attendance at the conference, which would not be possible without the generous support of the sponsors and exhibitors. We are grateful to them all and especially to our main sponsors this year, GSK, Eurofins Bioanalytical Services and SBI2 (Society of Biomolecular Imaging and Informatics). I hope that you all enjoy the symposium over the next two days. King regards, Dave Powell Director of Biological Sciences GlaxoSmithKline The organisation of this meeting required hard work and dedication from many individuals. In particular, I would like to thank the scientific committee of Rob Jepras (GlaxoSmithKline), David Lanham (Eurofins), FUTURE ELRIG MEETINGS: 18TH MARCH 2015 16TH & 17TH JUNE 2015 2ND & 3RD SEPTEMBER 2015 3RD NOVEMBER 2015 Research & Innovation ‘15 Advances in Cell Based Screening Drug Discovery ‘15 Trent Vineyard, Nottingham, UK AstraZeneca, Mölndal, Sweden Telford International Conference Centre, UK Advances in Recombinant Protein Technology AstraZeneca R&D, Alderley Park, Cheshire, UK SPEAKER PROGRAMME GSK CONFERENCE CENTER, WARE, UK 19TH - 20TH NOVEMBER 2014 DAY 1 WEDNESDAY 19TH DAY 2 THURSDAY 20TH 9:00 - 9:15 Opening Remarks – David Powell, GSK Session Chair – Rob Jepras, GSK 9:00 - 9:15 Session Chair - James Pilling, AstraZeneca 9:15 - 9.45 “Scar-in-a-Jar”: Enabling Phenotypic Screening for Extracellular Matrix Modulators Joanna Taylor, GSK 9:15 - 10:00 Induction of the Intrinsic Apoptotic Pathway by Biophotonic Nano-Switches Rachel Errington, Cardiff University 9.45 - 10:15 Accelerating Drug Discovery: Interrogating Relevant Human Biology with Quantitative High Throughput Endpoints Giorgia Salvagiotto, Cellular Dynamics 10:15 - 10:45 Coffee Break 10:45 - 11:30 Bulding a National Capability for Phenotypic Screening Andrew Hopkins, Dundee University 11:30 - 12:00 3D Culture - A Step Towards the Clinic Eric Tang, AstraZeneca Poster Taster Session 12:00 - 12:30 Poonam Shah (GSK), Jakub Nedbal (King’s College London), Hannah Compton (UCB) 12:30 - 1:00 Snapshots TTP Labtech, SBI2, BioTek Instruments, IntelliCyt, Sysmex Partec An Automated Fluorescence Lifetime Imaging Multiwell Plate Reader: Application to High 10:00 - 10:30 Content Imaging of Protein Interactions and Label Free Readouts of Cellular Metabolism Douglas Kelly, Imperial College London 10:30 - 11:00 Phenotypic Screening of Organelle Function Robin Ketteler, MRC LMCB 11:00 - 11:30 Coffee Break 11:30 - 12:00 Application of High Content Imaging to Cardiac Regeneration Discovery Elizabeth Mouchet, AstraZeneca HIV, Malaria and TB Monitoring in Research 12:00 - 12:30 Poor Settings Jane Wood, Partec UK Ltd 1:00 - 2:00 Lunch - Exhibition - Posters 12:30 - 1:00 Snapshots Chemometec, CM Technologies, LabLogic Systems, Caltag Medsystems, Thermo Fisher Scientific 2:00 - 3:00 Plenary Keynote - Flow Cytometry: Why Can’t It Do What the Other Screening Tools Do? J. Paul Robinson, Purdue University 1:00 - 2:15 Lunch - Exhibition - Posters 2:15 - 3:00 International Efforts to Establish Flow Cytometry Guidelines for Drug Development and Clinical Testing: Accomplishment and Next Steps Virginia Litwin, Covance 3:00 - 3:30 PK Assay for Biopharma Using Flow Cytometry Catherine de Coupade, LFB Biotechnologies 3:30 - 4:00 Coffee Break 4:30 - 5:00 Platelet Function Testing in Patients Following Myocardial Infarction Phillip Freeman, Fisher Freeman 4:00 - 4:30 Establishing, Growing and Running a Successful Core Facility - the Flow Cytometry Experience Derek Davies, London Research Institute 5:00 - 6:00 Poster Presentations 4:30 - 5:00 Close of Conference / Prize Draw 5:00 – 7:00 Drinks Reception in the Exhibit Hall 3:00 - 3:30 OutsideIn: Mapping Nanoparticle Agglomerate Across a Biological Interface Rowan Brown, Swansea University 3:30 - 4:00 Coffee Break 4:00 - 4:30 Mass Cytometry: A New Platform for Single Cell Characterization Marie Iannone, GSK PHARMACEUTICAL FLOW CYTOMETRY & IMAGING EXHIBITORS Partec UK Ltd www.sysmex-partec.com eBioscience, an Affymetrix company www.ebioscience.com Essen Nexcelom Bioscience Ltd www.nexcelom.com BioStatus Limited www.biostatus.com SBI2 www.sbi2.org/ BioLegend UK www.biolegend.com BioTek Instruments, Inc www.biotek.com Caltag Medsystems Ltd www.caltagmedsystems.com Integra Biosciences Ltd www.integra-biosciences.com Cambridge Bioscience www.bioscience.co.uk LabLogic Systems Limited www.lablogic.com Computype www.computype.com Thermo Scientific www.thermoscientific.com Bigneat www.bigneat.com CM Technologies OY www.c-mtechnologies.com Abcam Plc www.abcam.com Beckman Coulter www.beckmancoulter.com IntelliCyt Corporation www.intellicyt.com Wako Automation www.wakoautomation.com Sony Europe Limited Sony Biotechnology www.sonybiotechnology.com BioProcess Engineering Services Ltd www.bioprocess-eng.co.uk Contained Air Solutions www.containedairsolutions.co.uk Langton Howarth www.langtonhowarth.co.uk Chemometec A/S www.chemometec.com Perkin Elmer www.perkinelmer.com Phase Focus Limited www.phasefocus.com Labcyte Inc. www.labcyte.com TTP Labtech www.ttplabtech.com Peak Analysis & Automation Ltd www.paa-automation.com www.essenbioscience.com Miltenyi Biotec GmbH www.miltenyibiotec.com