1. health and fitness
2. disease
3. cholesterol

For the RETREATMENT of people whose
multiple myeloma has come back (relapsed)
after responding to VELCADE
Continue your treatment journey
with VELCADE® (bortezomib)
“I am prepared to
continue my fight
knowing that
VELCADE might
work again for me.”
Visit VELCADE.com to join the
patient support program and get
easy access to the tips, information,
and resources you need.
VELCADE (bortezomib) is approved for the treatment of people
with multiple myeloma (a cancer of the plasma cells).
Before you receive treatment with VELCADE, tell your doctor about
all of your medical conditions. You should not receive VELCADE if
you are allergic to bortezomib, boron, or mannitol. VELCADE must
not be administered into your spinal fluid (intrathecally).
Please see Important
Safety Information
inside this brochure
and accompanying full
Prescribing Information
for VELCADE.
What are the benefits
of retreatment with VELCADE?
How long will I be retreated
How
will I be on VELCADE?
withlong
VELCADE?
Retreatment with
VELCADE® (bortezomib) may
offer an additional benefit
▼
Retreatment schedule
with VELCADE® (bortezomib)
In a clinical trial, 130 people who had multiple
myeloma that had come back (relapsed) at least
6 months after having achieved a benefit with
VELCADE (bortezomib) received VELCADE again
▼
Your retreatment schedule with
VELCADE (bortezomib) may be different
from your original treatment schedule
▼
In a clinical trial, VELCADE retreatment was
given twice a week for 2 weeks, followed by a
10-day rest period. This was repeated up to
8 times (about 6 months)
– Patients received VELCADE with or
without dexamethasone
– 3 out of 8 people responded to retreatment
with VELCADE, with responses lasting about
6.5 months*
Retreatment cycles 1-8
TWICE WEEKLY, 3 WEEKS x8 (MAXIMUM)
*Half the patients’ responses lasted less than 6.5 months and half the
patients’ responses lasted more than 6.5 months.
F:10”
FS:9.5”
“Given that
VELCADE had
worked before,
I was thankful
to know that
retreatment
was an option.”
▼
▼
If you achieved a benefit with your first therapy
but have relapsed more than 6 months later,
▼
NATIONAL CANCER TREATMENT
GUIDELINES RECOMMEND
RETREATMENT with the same therapy
you received before.
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
VELCADE
Your doctor may start your retreatment
with VELCADE at the last dose you
were receiving
VELCADE can be given subcutaneously
(under your skin) or intravenously
(into your vein)
C
WEEKLY M
1
2
8
9
15
16
22
23
29
30
– Your doctor may consider starting you
on subcutaneous VELCADE if you have
numbness, tingling, burning, or weakness in
your hands or feet (peripheral neuropathy)TWICE WEE
or are at high risk for these symptoms
It’s essential to take treatment as prescribed 1 2
by your healthcare team. There are many
9
8
things to consider when choosing a treatment
plan that’s right for you
15 16
It’s important to stay committed
to your treatment plan.
Get the most out of VELCADE.
Please see Important Safety Information
inside this brochure.
1
F
Please see Important Safety Information
inside this brochure.
T:2
B:20
S:1
What
I expect
with
What
cancan
expect
with
What
can
II expect
with
VELCADE
retreatment?
VELCADE retreatment?
retreatment?
VELCADE
While
receiving
While
receiving
While
receiving
® ® (bortezomib), it’s
®
VELCADE
VELCADE
(bortezomib), it’s
it’s
VELCADE
(bortezomib),
important
speak
about
important
toto
speak
upup
about
important
to
speak
up
about
how
you
feel
how
you
feel
how
you
feel
a clinical
of retreatment
with
InaaIn
clinical
trialtrial
ofretreatment
retreatment
with
In
clinical
trial
of
with
VELCADE
(bortezomib),
most
common
VELCADE
(bortezomib),
thethe
most
common
sideside
VELCADE
(bortezomib),
the
most
common
side
effects
were:
effectswere:
were:
effects
▼ Abnormal
▼ Abnormal
levels
of blood
cells
as determined
▼
Abnormal
levels
ofblood
blood
cells
asdetermined
determined
by by
levels
of
cells
as
by
regular
blood
tests
regularblood
bloodtests
tests
regular
▼ Tingling
▼ Tingling
or numbness
in the
hands,
arms,
feet,
▼
Tingling
ornumbness
numbness
inthe
the
hands,
arms,
feet,
or
in
hands,
arms,
feet,
or legs
(peripheral
neuropathy)
orlegs
legs
(peripheral
neuropathy)
or
(peripheral
neuropathy)
13%
of patients
stopped
treatment
to side
effects.
13%
ofpatients
patients
stopped
treatment
duedue
toside
side
effects.
13%
of
stopped
treatment
due
to
effects.
Side
effects
worse
Side
effects
diddid
notnot
getget
worse
Side
effects
did
not
get
worse
with
retreatment.
with
retreatment.
with
retreatment.
▼ When
starting
retreatment,
be
sure
to talk
▼ When
When
starting
retreatment,
be sure
sure
to talk
talk
to to
▼
starting
retreatment,
be
to
to
your
doctor
about
other
health
conditions
your
doctor
about
anyany
other
health
conditions
your
doctor
about
any
other
health
conditions
have
or medications
you’re
taking
youyou
have
or medications
medications
you’re
taking
you
have
or
you’re
taking
▼you
If you
have
effects
with
VELCADE,
▼ If
If
you
have
anyany
sideside
effects
with
VELCADE,
▼
have
any
side
effects
with
VELCADE,
tell
your
doctor
or
nurse
right
away
tell your
your doctor
doctor or
or nurse
nurse right
right away
away
tell
▼ Your
healthcare
team
might
decide
to change
▼ Your
Your
healthcare
team
might
decide
to change
change
▼
healthcare
team
might
decide
to
your
dose
or
schedule
of
VELCADE
to help
your
dose
or
schedule
of
VELCADE
to
help
your dose or schedule of VELCADE to help
you
stay
on
treatment
you stay
stay on
on treatment
treatment
you
▼ Ask
your
doctor
about
treatment
shingles
▼ Ask
Ask
your
doctor
about
treatment
forfor
shingles
▼
your
doctor
about
treatment
for
shingles
when
starting
retreatment
with
VELCADE
when
starting
retreatment
with
VELCADE
when
starting
retreatment
with
VELCADE
Please
Important
Safety
Information
Please
seesee
Important
Safety
Information
Please
see
Important
Safety
Information
on adjacent
pages.
onadjacent
adjacent
pages.
on
pages.
Indication
and
Important
Indication
and
Important
Indication
and
Important
Safety
Information
Safety
Information
forfor
Safety
Information
for
®
®
®
VELCADE(bortezomib)
(bortezomib)
VELCADE
(bortezomib)
VELCADE
What
is VELCADE
used
for?
What
is VELCADE
VELCADE
used
for?
What
is
used
for?
VELCADE
(bortezomib)
is
approved
for
VELCADE(bortezomib)
(bortezomib)isisapproved
approvedfor
forthe
thethe
VELCADE
treatment
of
patients
with
multiple
myeloma
treatmentof
ofpatients
patientswith
withmultiple
multiplemyeloma
myeloma
treatment
(a cancer
of the
plasma
cells).
(acancer
cancer
ofthe
the
plasma
cells).
(a
of
plasma
cells).
How
is VELCADE
administered?
How
is VELCADE
VELCADE
administered?
How
is
administered?
VELCADE
is
prescribed
a physician
VELCADE
is
prescribed
by aby
a physician
physician
VELCADE is prescribed by
experienced
in
the
use
of
medications
to treat
experienced
in
the
use
of
medications
to treat
treat
experienced in the use of medications to
cancer.
It
is
administered
by
a
healthcare
cancer.
It
is
administered
by
a
healthcare
cancer. It is administered by a healthcare
professional
as injection
an
injection
your
vein
professional
as an
an
injection
intointo
your
vein
professional
as
into
your
vein
(intravenously,
or
IV)
or
under
your
skin
(intravenously,
or
IV)
or
under
your
skin
(intravenously, or IV) or under your skin
(subcutaneously).
VELCADE
must
(subcutaneously).
VELCADE
must
notnot
be be
(subcutaneously).
VELCADE
must
not
be
administered
into
your
spinal
fluid
(intrathecally).
administered
into
your
spinal
fluid
(intrathecally).
administered into your spinal fluid (intrathecally).
Who
should
receive
VELCADE?
Who
should
notnot
receive
VELCADE?
Who
should
not
receive
VELCADE?
Before
receive
treatment
with
VELCADE,
tell
your
Before
youyou
receive
treatment
with
VELCADE,
tellyour
your
Before
you
receive
treatment
with
VELCADE,
tell
doctor
about
allyour
of your
medical
conditions.
should
doctor
about
allof
of
your
medical
conditions.
YouYou
should
doctor
about
all
medical
conditions.
You
should
receive
VELCADE
if you
allergic
to bortezomib,
notnot
receive
VELCADE
you
areare
allergic
tobortezomib,
bortezomib,
not
receive
VELCADE
ififyou
are
allergic
to
boron,
or mannitol.
boron,
ormannitol.
mannitol.
boron,
or
What
possible
side
effects
of VELCADE?
What
areare
thethe
possible
side
effects
ofVELCADE?
VELCADE?
What
are
the
possible
side
effects
of
VELCADE
cause
serious
effects,
including:
VELCADE
cancan
cause
serious
sideside
effects,
including:
VELCADE
can
cause
serious
side
effects,
including:
▼
▼ Peripheral
Peripheral
neuropathy.
VELCADE
▼
Peripheral
neuropathy.
VELCADE
cancan
neuropathy.
VELCADE
can
cause
damage
to the
nerves,
a condition
called
cause
damage
to the
the
nerves,
condition
called
cause
damage
to
nerves,
aa condition
called
peripheral
neuropathy.
may
muscle
peripheral
neuropathy.
YouYou
may
feelfeel
muscle
peripheral
neuropathy.
You
may
feel
muscle
weakness,
tingling,
burning,
pain,
weakness,
tingling,
burning,
pain,
andand
lossloss
of of
weakness,
tingling,
burning,
pain,
and
loss
of
feeling
in your
hands
feet,
of which
feeling
in your
your
hands
andand
feet,
anyany
of which
which
cancan
feeling
in
hands
and
feet,
any
of
can
be
severe.
your
doctor
if you
notice
be severe.
severe.
TellTell
your
doctor
you
notice
anyany
of of
be
Tell
your
doctor
ifif you
notice
any
of
these
symptoms.
Your
doctor
may
change
these
symptoms.
Your
doctor
may
change
thethe
these
symptoms.
Your
doctor
may
change
the
dose
and/or
schedule
of VELCADE
or stop
dose
and/or
schedule
of VELCADE
VELCADE
or stop
stop
dose
and/or
schedule
of
or
itit it
altogether.
If you
have
peripheral
neuropathy
altogether.
you
have
peripheral
neuropathy
altogether.
IfIf you
have
peripheral
neuropathy
before
starting
VELCADE,
your
doctor
could
before
starting
VELCADE,
your
doctor
could
before
starting
VELCADE,
your
doctor
could
consider
giving
VELCADE
subcutaneously.
consider
giving
youyou
VELCADE
subcutaneously.
consider
giving
you
VELCADE
subcutaneously.
▼ Low
▼ Low
blood
pressure.
VELCADE
cause
▼
Low
blood
pressure.
VELCADE
cancan
cause
blood
pressure.
VELCADE
can
cause
aa a
drop
in
blood
pressure.
Tell
your
doctor
if
you
have
dropin
inblood
bloodpressure.
pressure.Tell
Tellyour
yourdoctor
doctorififyou
youhave
have
drop
low
blood
pressure,
feel
dizzy,
or
feel
as
though
lowblood
bloodpressure,
pressure,feel
feeldizzy,
dizzy,or
orfeel
feelas
asthough
though
low
might
faint.
If you
taking
drugs
lower
youyou
might
faint.
you
areare
taking
drugs
thatthat
lower
you
might
faint.
IfIfyou
are
taking
drugs
that
lower
blood
pressure,
your
medications
might
need
bloodpressure,
pressure,your
yourmedications
medicationsmight
mightneed
needto
to to
blood
be
adjusted.
If
you
are
not
drinking
enough
liquids,
beadjusted.
adjusted.IfIfyou
youare
arenot
notdrinking
drinkingenough
enoughliquids,
liquids,
be
your
doctor
may
need
to
administer
IV
fluids.
yourdoctor
doctormay
mayneed
needto
toadminister
administerIV
IVfluids.
fluids.
your
▼ Heart
▼ Heart
problems.
Treatment
with
VELCADE
▼
Heart
problems.
Treatment
with
VELCADE
cancan
problems. Treatment with VELCADE can
cause
or
worsen
heart
rhythm
problems
and
heart
cause
or
worsen
heart
rhythm
problems
and
heart
cause or worsen heart rhythm problems and heart
failure.
Your
doctor
may
closely
monitor
you
if
failure.
Your
doctor
may
closely
monitor
you
if
failure. Your doctor may closely monitor you if
have,
or are
at risk
heart
disease.
your
youyou
have,
orare
are
atrisk
risk
for,for,
heart
disease.
TellTell
your
you
have,
or
at
for,
heart
disease.
Tell
your
doctor
if
you
experience
chest
pressure
or
pain,
doctor
if
you
experience
chest
pressure
or
pain,
doctor if you experience chest pressure or pain,
palpitations,
swelling
of your
ankles
or feet,
palpitations,
swelling
ofyour
your
ankles
orfeet,
feet,
or or
palpitations,
swelling
of
ankles
or
or
shortness
of
breath.
shortness
of
breath.
shortness of breath.
▼ Lung
▼ Lung
problems.
There
have
been
reports
▼
Lung
problems.
There
have
been
reports
of of
problems.
There
have
been
reports
of
lung
disorders
in patients
receiving
lung
disorders
inpatients
patients
receiving
lung
disorders
in
receiving
VELCADE
(bortezomib).
Some
of these
events
VELCADE
(bortezomib).
Some
ofthese
these
events
VELCADE
(bortezomib).
Some
of
events
have
been
fatal.
your
doctor
if you
experience
have
been
fatal.
TellTell
your
doctor
you
experience
have
been
fatal.
Tell
your
doctor
ififyou
experience
coughing,
shortness
of breath,
wheezing,
anyany
coughing,
shortness
ofbreath,
breath,
wheezing,
or or
any
coughing,
shortness
of
wheezing,
or
difficulty
breathing.
difficulty
breathing.
difficulty
breathing.
▼ Liver
▼ Liver
problems.
If you
have
liver
problems,
it can
▼
Liver
problems.
you
have
liver
problems,
can
problems.
IfIfyou
have
liver
problems,
ititcan
be harder
for
your
body
to get
rid
of VELCADE.
beharder
harder
foryour
your
body
toget
get
ridof
ofVELCADE.
VELCADE.
be
for
body
to
rid
VELCADE
caused
sudden
liver
failure
VELCADE
hashas
caused
sudden
liver
failure
in in
VELCADE
has
caused
sudden
liver
failure
in
patients
who
were
taking
many
medications
patients
who
were
taking
many
medications
or or
patients
who
were
taking
many
medications
or
other
serious
medical
conditions.
Symptoms
hadhad
other
serious
medical
conditions.
Symptoms
had
other
serious
medical
conditions.
Symptoms
of liver
problems
include
a yellow
discoloration
ofliver
liver
problems
include
yellow
discoloration
of of
of
problems
include
aayellow
discoloration
of
eyes
(jaundice)
changes
in liver
thethe
eyes
andand
skinskin
(jaundice)
andand
changes
inliver
liver
the
eyes
and
skin
(jaundice)
and
changes
in
enzymes
measured
in blood
tests.
Your
doctor
enzymes
measured
inblood
blood
tests.
Your
doctor
willwill
enzymes
measured
in
tests.
Your
doctor
will
closely
monitor
if you
have
liver
disease.
closely
monitor
youyou
you
have
liver
disease.
closely
monitor
you
ififyou
have
liver
disease.
▼ Posterior
▼ Posterior
reversible
encephalopathy
▼
Posterior
reversible
encephalopathy
reversible
encephalopathy
syndrome
(PRES).
There
have
been
reports
syndrome
(PRES).
There
have
been
reports
ofaaof a
syndrome
(PRES).
There
have
been
reports
of
rare,
reversible
condition
involving
brain,
called
rare,
reversible
condition
involving
thethe
brain,
called
rare,
reversible
condition
involving
the
brain,
called
PRES,
in patients
treated
with
VELCADE.
Patients
PRES,
inpatients
patients
treated
with
VELCADE.
Patients
PRES,
in
treated
with
VELCADE.
Patients
with
PRES
have
seizures,
high
blood
pressure,
with
PRES
cancan
have
seizures,
high
blood
pressure,
with
PRES
can
have
seizures,
high
blood
pressure,
headaches,
tiredness,
confusion,
blindness,
or other
headaches,
tiredness,
confusion,
blindness,
orother
other
headaches,
tiredness,
confusion,
blindness,
or
vision
problems.
Treatment
with
VELCADE
should
vision
problems.
Treatment
with
VELCADE
should
vision
problems.
Treatment
with
VELCADE
should
be stopped
in cases
of PRES.
bestopped
stopped
incases
cases
ofPRES.
PRES.
be
in
of
▼ Gastrointestinal
▼ Gastrointestinal
problems.
VELCADE
▼
Gastrointestinal
problems.
VELCADE
problems.
VELCADE
treatment
can
cause
nausea,
vomiting,
diarrhea,
treatmentcan
cancause
causenausea,
nausea,vomiting,
vomiting,diarrhea,
diarrhea,
treatment
and
constipation.
If
your
symptoms
are
severe,
your
andconstipation.
constipation.IfIfyour
yoursymptoms
symptomsare
aresevere,
severe,
your
and
your
doctor
may
recommend
IV
fluids
and/or
medications.
doctormay
mayrecommend
recommendIV
IVfluids
fluidsand/or
and/ormedications.
medications.
doctor
▼ Neutropenia
▼ Neutropenia
(low
levels
of
neutrophils,
▼
Neutropenia
(low
levels
of
neutrophils,
(low levels of neutrophils, aa a
type
of
white
blood
cell).
VELCADE
cause
type
of
white
blood
cell).
VELCADE
cancan
cause
type of white blood
cell).
VELCADE
can
cause
low
levels
of
white
blood
cells
(infection-fighting
low
levels
of
white
blood
cells
(infection-fighting
low levels of white blood cells (infection-fighting
cells).
If your
white
blood
cells
become
cells).
your
white
blood
cells
become
low,low,
youyou
cancan
cells).
IfIfyour
white
blood
cells
become
low,
you
can
be
at
higher
risk
for
infections.
Tell
your
doctor
be
at
higher
risk
for
infections.
Tell
your
doctor
if
be at higher risk for infections. Tell your doctor if if
develop
a fever
or believe
have
an infection.
youyou
develop
fever
orbelieve
believe
youyou
have
aninfection.
infection.
you
develop
aafever
or
you
have
an
▼ Thrombocytopenia
▼ Thrombocytopenia
(low
levels
of platelets).
▼
Thrombocytopenia
(low
levels
of platelets).
platelets).
(low
levels
of
VELCADE
cause
levels
of platelets
(clotVELCADE
cancan
cause
lowlow
levels
ofplatelets
platelets
(clotVELCADE
can
cause
low
levels
of
(clotforming
cells).
If platelets
become
very
there
forming
cells).
platelets
become
very
low,low,
there
forming
cells).
IfIfplatelets
become
very
low,
there
isincreased
an increased
of bleeding.
Your
doctor
may
an
increased
riskrisk
ofbleeding.
bleeding.
Your
doctor
may
isisan
risk
of
Your
doctor
may
recommend
a platelet
transfusion.
recommend
platelet
transfusion.
recommend
aaplatelet
transfusion.
have
regular
blood
tests
to check
your
YouYou
willwill
have
regular
blood
tests
tocheck
check
your
cellcell
You
will
have
regular
blood
tests
to
your
cell
counts
during
your
treatment
with
VELCADE.
If the
counts
during
your
treatment
with
VELCADE.
the
counts during your treatment with VELCADE. IfIfthe
number
of
these
cells
is
very
low,
your
doctor
may
number
of
these
cells
is
very
low,
your
doctor
may
number of these cells is very low, your doctor may
change
dose
and/or
schedule
of VELCADE.
change
thethe
dose
and/or
schedule
ofVELCADE.
VELCADE.
change
the
dose
and/or
schedule
of
▼ Tumor
▼ Tumor
lysis
syndrome
(TLS).
TLS
▼
Tumor
lysis
syndrome
(TLS).
TLS
lysis
syndrome
(TLS).
TLS
isis aais a
syndrome
causes
a chemical
imbalance
syndrome
thatthat
causes
chemical
imbalance
in in
syndrome
that
causes
aa chemical
imbalance
in
blood
could
lead
to heart
and/or
kidney
thethe
blood
thatthat
could
lead
to heart
heart
and/or
kidney
the
blood
that
could
lead
to
and/or
kidney
problems.
TLS
occur
with
cancer
treatments,
problems.
TLS
cancan
occur
with
cancer
treatments,
problems.
TLS
can
occur
with
cancer
treatments,
your
doctor
be
monitoring
your
blood
andand
your
doctor
willwill
be monitoring
monitoring
your
blood
and
your
doctor
will
be
your
blood
urine
signs
of this
syndrome.
If you
andand
urine
forfor
anyany
signs
of this
this
syndrome.
you
and
urine
for
any
signs
of
syndrome.
IfIf you
develop
TLS,
your
doctor
take
appropriate
develop
TLS,
your
doctor
willwill
take
appropriate
develop
TLS,
your
doctor
will
take
appropriate
steps
to treat
steps
to treat
treat
it. it.
steps
to
it.
More
than
5 patients
(20%)
receiving
More
than
in155inpatients
patients
(20%)
receiving
More
than
11 in
(20%)
receiving
VELCADE
(bortezomib)
have
experienced
VELCADE
(bortezomib)
have
experienced
VELCADE
(bortezomib)
have
experienced
following
side
effects:
nausea,
diarrhea,
thethe
following
side
effects:
nausea,
diarrhea,
the
following
side
effects:
nausea,
diarrhea,
thrombocytopenia,
neutropenia,
peripheral
thrombocytopenia,
neutropenia,
peripheral
thrombocytopenia,
neutropenia,
peripheral
neuropathy,
fatigue,
neuralgia
(nerve
pain),
neuropathy,
fatigue,
neuralgia
(nerve
pain),
neuropathy,
fatigue,
neuralgia
(nerve
pain),
anemia,
leukopenia
(low
levels
of white
blood
anemia,
leukopenia
(low
levels
of white
white
blood
anemia,
leukopenia
(low
levels
of
blood
cells),
constipation,
vomiting,
lymphopenia
(low
cells),
constipation,
vomiting,
lymphopenia
(low
cells),
constipation,
vomiting,
lymphopenia
(low
levels
a certain
type
of white
blood
cells),
levels
of aaofcertain
certain
type
of white
white
blood
cells),
levels
of
type
of
blood
cells),
rash,
pyrexia
(fever),
anorexia.
rash,
pyrexia
(fever),
andand
anorexia.
rash,
pyrexia
(fever),
and
anorexia.
What
other
information
should
you
discuss
What
other
information
should
you
discuss
What
other
information
should
you
discuss
with
your
doctor?
with your
your doctor?
doctor?
with
Women
should
avoid
becoming
pregnant
or breastWomen
should
avoid
becoming
pregnant
orbreastbreastWomen
should
avoid
becoming
pregnant
or
feeding
while
being
treated
with
VELCADE.
feeding
while
being
treated
with
VELCADE.
feeding
while
being
treated
with
VELCADE.
Discuss
with
your
doctor
when
is safe
to restart
Discuss
with
your
doctor
when
safe
torestart
restart
Discuss
with
your
doctor
when
ititisisitsafe
to
breast-feeding
after
finishing
your
treatment.
breast-feeding
after
finishing
your
treatment.
breast-feeding
after
finishing
your
treatment.
should
also
your
doctor
if you:
YouYou
should
also
telltell
your
doctor
you:
You
should
also
tell
your
doctor
ifif you:
▼ Have
▼ Have
kidney
disease.
If you
on dialysis,
▼
Have
kidney
disease.
you
areare
ondialysis,
dialysis,
kidney
disease.
IfIfyou
are
on
your
doctor
will
administer
VELCADE
after
your
doctor
will
administer
VELCADE
after
your doctor will administer VELCADE after
the
dialysis
procedure.
the
dialysis
procedure.
the dialysis procedure.
▼ Are
▼ Are
taking
medication
for
diabetes.
VELCADE
▼
Are
taking
medication
fordiabetes.
diabetes.
VELCADE
taking
medication
for
VELCADE
can
affect
your
blood
glucose
levels.
doctor
can
affect
your
blood
glucose
levels.
Your
doctor
can affect your blood glucose levels. YourYour
doctor
may
require
close
monitoring
of
your
blood
may
require
close
monitoring
of
your
blood
may require close monitoring of your blood
glucose
levels
change
dose
of your
glucose
levels
andand
change
thethe
dose
ofyour
your
glucose
levels
and
change
the
dose
of
diabetes
medicine
while
you
are
being
treated
diabetes
medicine
while
you
are
being
treated
diabetes medicine while you are being treated
with
VELCADE.
with
VELCADE.
with VELCADE.
▼ Have
▼ Have
liver
disease.
▼
Have
liver
disease.
liver
disease.
▼ Are
▼ Are
using
other
medications,
including
▼
Are
using
anyany
other
medications,
including
using
any
other
medications,
including
prescription
over-the-counter
drugs,
prescription
andand
over-the-counter
drugs,
prescription
and
over-the-counter
drugs,
herbal
or dietary
supplements,
or holistic
herbal
or dietary
dietary
supplements,
or holistic
holistic
herbal
or
supplements,
or
treatments.
St.
John’s
wort
should
be
avoided.
treatments.
St. John’s
John’s
wort
should
be avoided.
avoided.
treatments.
St.
wort
should
be
▼
▼ Develop
Develop
a rash
of any
type
while
▼
Develop
rash
of any
any
type
while
aa rash
of
type
while
receiving
VELCADE.
receiving
VELCADE.
receiving
VELCADE.
side
effects
of VELCADE
may
impair
your
TheThe
side
effects
of VELCADE
VELCADE
may
impair
your
The
side
effects
of
may
impair
your
ability
to
drive
or
operate
machinery.
ability
to
drive
or
operate
machinery.
ability to drive or operate machinery.
These
all
of the
possible
side
effects
These
areare
notnot
all of
of the
the
possible
side
effects
These
are
not
all
possible
side
effects
with
VELCADE.
It
is
important
to
always
with
VELCADE.
It
is
important
to
always
with VELCADE. It is important to always
contact
your
doctor
if you
experience
side
contact
your
doctor
you
experience
anyany
side
contact
your
doctor
ifif you
experience
any
side
effects
while
on
VELCADE.
If
you
have
any
effects
while
on
VELCADE.
If
you
have
any
effects while on VELCADE. If you have any
questions
about
VELCADE,
contact
your
doctor.
questions
about
VELCADE,
contact
your
doctor.
questions
about
VELCADE,
contact
your
doctor.
Additional
information
is
available
on
the
Additional
information
is
available
on
the
Additional information is available on the
website
at VELCADE.com.
website
at VELCADE.com.
VELCADE.com.
website
at
Please
accompanying
Prescribing
Information
Please
seesee
accompanying
fullfull
Prescribing
Information
Please
see
accompanying
full
Prescribing
Information
for
VELCADE.
forVELCADE.
VELCADE.
for
Inside:
Benefits of
VELCADE® (bortezomib)
Retreatment with VELCADE (bortezomib)
may offer an additional benefit.
Treatment schedules
Managing side effects
Understand side effects of VELCADE
and talk to your healthcare team about
managing them.
How can VELCADE offer me support?
The VELCADE patient support
program offers many resources
to help you along your journey
Services include:
▼
Tips for your journey
with VELCADE
▼
A Patient Resource Kit
for multiple myeloma
▼
Up-to-date information
on VELCADE and
multiple myeloma
▼
Access to web-based
material weekly for the
next 6 months
▼
Invitations to hear
from experts and other
people like you
Visit VELCADE.com to join the
patient support program and get
easy access to the tips, information,
and resources you need.
Please see Important Safety Information inside this
brochure and accompanying full Prescribing Information
for VELCADE.
VELCADE, MILLENNIUM and
are registered
trademarks of Millennium Pharmaceuticals, Inc.
Other trademarks are property of their respective owners.
Millennium Pharmaceuticals, Inc., Cambridge, MA 02139
Copyright © 2014, Millennium Pharmaceuticals, Inc.
All rights reserved.
Printed in USA
V-14-0353
10/14
Please see full Prescribing Information at
velcade.com/Files/PDFs/VELCADE_PRESCRIBING_INFORMATION.pdf