1. No category

Annual Report 2014
NORMENT – Annual Report 2014 | 12
Norwegian Centre for Mental
Disorders Research (NORMENT)
Norwegian Centre for Mental Disorders Research
(NORMENT) is a Norwegian Centre of
Excellence established by the Research Council
of Norway in July 2013.
NORMENT is integrated with the K. G. Jebsen
Centre for Psychosis Research, funded by the
K.G. Jebsen Foundation. This provides a unique
opportunity to perform comprehensive and longterm research, reaching across the country.
The Centre has a clear clinical profile, involving
investigations of patients with state-of-the art
clinical assessments and research technology,
and translating findings to experimental studies
for the identification of underlying mechanisms.
We have ambitious scientific goals, focusing on
understanding the underlying mechanisms of
severe mental disorders. This is a field with large
unmet needs and lack of knowledge, which
makes the work of our Centre of Excellence very
important. We have focused on four main areas
of activities to answer the following research
questions:
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Why do antipsychotic medications have
severe side effects?
How can brain imaging help link genes to
clinical characteristics?
Where is the ‘hidden heritability’ of
severe mental disorders?
How can we predict outcome in patients
experiencing their first signs of disease?
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NORMENT Annual report 2014 | 2
Leader’s comments
Vision Statement
Scientific aims
Achievements 2014
Scientific currency
Happenings 2014
NORMENT Annual Retreat
Core Researchers
Translational Psychiatry
Clinical Psychosis Research
Psychiatric Molecular Genetics
Brain Imaging
Neurocognition
Structural MRI
Convergent functional genomics
Animal models
International Cooperation
New employees 2014
NORMENT Staff
Activities 2014
Visits Abroad
Visits from Abroad
Further International Cooperation
Presentations 2014
Disputations 2014
NORMENT in Media
Publications 2014
Funding
Leader’s comments
The first phase of the NORMENT has been used to
establish the Centre identity, both in terms of
scientific focus and coordinated organisation and
communication. We have made significant
progress in these aspects in 2014, and the first full
year of activity turned out to be a productive and
rewarding year for the NORMENT Centre.
We have also provided evidence how animal
models can be used for translational studies
of antipsychotic side effects, and shown how
schizophrenia risk genes relate to immune
system induce abnormal behaviour and
altered brain function when transferred to
mouse models.
We have continued to develop a synergistic team
of research groups and work units, and established
structures for project coordination, expertise
sharing and strong method platforms. The scientific
achievements have been excellent. We have
participated in discovery of new gene variants
associated with psychiatric disorders, and
especially the Nature paper in July identifying 108
gene variants for schizophrenia was a
breakthrough in the field.
These aspects are now followed up in new
clinical studies focusing on prediction of longterm course and outcome. Emerging data
indicates that early treatment response is a
key predictor. There are always several
challenges involved in developing a new
Centre of Excellence, and the current most
pressing issue is the lack of adequate office
and lab space, which we hope will be
finalized in 2015.
We have also found indications that socioeconomic
stressors in adolescence may increase the risk for
psychotic disorders and that environmental risk
factors reduce the age at onset of bipolar disorder
and are likely to be involved in the development of
the disorder, with indications of gene x
environmental interactions. Using state-of-the-art
brain imaging tools, we have determined how
environmental factors (obstetric complications)
affect brain development, and may play a causative
role in psychiatric disorders.
Despite this limitation, the coordination of the
research activity between the different
partners seems to work very well, and we
have been successful in recruiting new and
talented researchers to the Centre.
This makes me very optimistic for the next
year and I look forward to new discoveries in
2015.
Furthermore, the Centre has developed new
statistical methodology to boost the power of
genetic studies, thereby strongly increasing the
output from genetics data in many fields of human
disease research.
Ole A. Andreassen,
Director NORMENT
NORMENT Annual report 2014 | 3
Vision statement
NORMENT’s primary objective is to reveal underlying pathophysiological mechanisms in schizophrenia
and bipolar disorder and to develop tools for stratification and outcome prediction, using a vertical
synergy approach, with the following sub goals:
1) Define new targets to optimize the ratio of beneficial vs.
adverse effects of antipsychotics.
2) Identify genetic variants or expression variation to reveal
‘missing heritability’.
3) Determine new brain imaging phenotypes linking genes
and core clinical phenotypes.
4) Use genetic and environmental factors to predict disease
progress and outcome.
We will take advantage of the homogeneity of the Norwegian population (genetic background, health
care system, registries) as the basis for collecting large samples of affected and unaffected people.
These individuals will be characterized with the same clinical, cognitive, biochemical and imaging
protocols to identify new mechanisms which will be studied functionally in animal and cell culture
models.
Scientific aims
1. Define New Targets for Antipsychotic Medication
Antipsychotic medications are the cornerstone in the treatment of schizophrenia, and have in recent years
also been used for bipolar disorder. The medications are not equally effective for all patients, and have a
limited effect on the core symptoms for approximately 20 % of those treated.
Adverse effects are problematic and in some cases serious, such as cardiovascular risk factors (weight gain,
abnormal fat levels in the blood, diabetes etc.). Research at NORMENT has a particular focus on the
immune and lipid (fat) metabolism systems.
We use animal and other experimental models to enhance our knowledge about the mechanisms of action
of antipsychotic medication. We aim to optimize antipsychotic treatment by increasing the desired effect of
medication and reducing adverse effects.
NORMENT Annual report 2014 | 4
2. Identify Genetic Factors for Psychiatric
Disorders – Common and Rare Variants
Family and twin studies have shown that
schizophrenia and bipolar disorder have high
heritability. Researchers at NORMENT have
contributed to major international GWA (“genomewide association studies”). We have found evidence
for new vulnerability genes for these disorders.
Preliminary results show that inherited changes in
many genes (i.e. gene variants) are involved, but
each variant contributes to a relatively modest degree.
The identified gene variants explain only a small
portion of susceptibility to psychotic dis- orders.
Heritability is therefore still far from fully explained.
In our research, we use combined approaches that
include new genotyping methods to identify rare
genetic variants. We also use new statistical methods
for mapping multiple gene variants, each of which has
a small effect on its own.
3. Brain Imaging: Identify Brain MRI
Phenotypes Linking Genes to Core
Clinical Phenotypes
Advanced neuroimaging techniques including
structural and functional MRI have revolutionized the
understanding of the structural and functional makeup
of the human brain.
NORMENT researchers have contributed to the
identification of structural brain abnormalities in
schizophrenia, including volumetric alterations in front
temporal cortical areas and subcortical structures.
Partly overlapping and partly diverging patterns have
been found in bipolar disorder.
Structural and functional brain phenotypes are highly
heritable, and current research at NORMENT aims to
identify the genetic underpinnings of individual
differences in the structural and functional
organization of the human brain, and to disentangle
the genetic and phenotypic associations with severe
neuropsychiatric disorders.
4. Predict Course and Outcome –Including Mortality
Some patients with severe mental disorders recover completely while others develop chronic illness. Currently,
we can mainly make general assumptions about the most likely prognosis for someone who develops a severe
mental illness and are not able to predict the personal outcome for individual patients. One of the main goals for
NORMENT is to investigate how we can improve our understanding of course and outcome. Ultimately, the goal
is to make personalized predictions for patients coming to their first treatment. We are doing this by examining
how genetic- and environmental risk factors influence the course of the disorder, by combining clinical- and
cognitive assessments with brain imaging.
During 2014, the main focus has been on investigating how specific environmental risk factors influence clinical, cognitive- and morphological characteristics either individually, or in interaction with other environmental and
genetic risk factors. At present, we are studying the effects of early traumatic events, cannabis use and
migration- with additional studies of how the effects of trauma interact with the effects of cannabis use and of
migration. We have also studied how trauma interacts with genetic factors – in this case variant in the BDNF
gene – on cognition and on structural changes in hippocampal subfields.
This line of research is done in close collaboration with several of NORMENT’s groups and with international
colleagues in Paris, France and Milan, Italy. To study the effects on course and outcome we also need welldescribed patient cohorts followed from their first treatment. Within the NORMENT Centre we have established
a large first-treatment schizophrenia spectrum cohort and are working to establish a first-treatment bipolar
spectrum cohort in collaboration with Norwegian colleagues in the NORSMI network. We are now ready to
launch a long-term (5 and 10 year follow ups) of the schizophrenia cohort. We have already started out a fiveyear follow up of patients at Innlandet Hospital in collaboration with the regional research network. The first part
of the long-term follow-up will have a particular focus on functioning, cognition and negative symptoms.
NORMENT Annual report 2014 |
5
Achievements

Implemented new statistical tools for gene
based association analyses and allelic
heterogeneity

Participated in genetic and imaging
genetics consortia for large scale
association discovery

Developed a team in translational psychiatry,
focusing on immune and cardiovascular
comorbidity

Genotyped a large sample of cases and
controls, nearly 25 000 participants

Developed new MRI multimodal imaging
analysis protocol

Started upgrade of Centre MRI scanners in
both Bergen and Oslo and synchronized
protocols

Established principles for ‘biophysical
psychiatry’ approach

Received NIH funding for a big data grant
(big data to knowledge, BD2K) involving
the ENIGMA study

Completed data collection for cognitive
remediation study and social cognition
PhD project

New biomarkers: NMDA receptor
antibodies, viral serology

Finished the protocol for a long-term follow-up
study of first episode patients

New neurocognitive and functional outcome
protocol for 5-, 10-, and future NORMENT
follow up studies developed

Developed a new smartphone app for sampling
of symptom-data in real-time, collaboration
between Bergen and Oslo

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Several translational studies listed in Research
aims/deliverables published and/or submitted
Improved the new statistical tools for improved
gene discovery in a range of polygenic complex
disorders

First study on the relationship between
temporal and frontal lobe glutamate
concentrations and PANSS hallucination scores
published

Investigate for consistency of MR measures
across scanners

Longitudinal neuroimaging – 1-year follow-up
finished
NORMENT Annual report 2014 |
6
Scientific currency
Papers
Dissemination of research result
NORMENT scientist authored or co-authored 102
papers in international peer-reviewed journals in 2014.
Of the papers published in 2014, 25 papers appeared
in journals with an impact factor above 5. Six of these
appeared in journals with an impact factor above 15,
(one with impact factor above 35). In general the
quality and visibility of publications from the Centre is
high.
NORMENT members gave 48 talks as
invited speakers at international scientific
meetings in 2014. In addition 105 oral
presentations and 56 posters were
presented by NORMENT scientists.
NORMENT staff gave also 65 lectures,
aimed at a targeted audience and the
general public.
NORMENT scientists have extensive collaborations
with national and international research groups. More
than 50 % of the papers published in 2014 with one or
more NORMENT authors are the result of
collaborations with national institutions. Impact factor
based on collaborations are illustrated in the figures
below. NORMENT publications in 2014 are presented
on page 28 of this report. National and international
collaborators are listed on page 20 and 22.
These include postgraduate lectures,
research seminars, training course at
universities and hospitals. Talks, posters
and dissemination activities aimed at
targeted audience and the public, as well as
media coverage, are listed in the back of
this report.
Impact Factor Distribution - NORMENT
Publications 2014
8%
32 %
<5
60 %
5 - 15
> 15
Publications with one or more NORMENT authores
14 %
1
50 %
36 %
2-4
>5
Prizes and awards:
Professor Kenneth Hugdahl was awarded the
2014 “Møbius” prize, from the Research Council
of Norway.
http://www.forskningsradet.no/no/Nyheter/Forsk
ningsrdet_deler_ut_tre_priser_i_dag/125400158
1512?lang=no
Professor Kenneth Hugdahl received honorary
Meltzer Award for 2013, from University of
Bergen.
http://www.uib.no/aktuelt/63020/meltzers%C3%A6respris-til-kenneth-hugdahl
Post doc Monica Aas received 2014 NARSAD
Young Investigator Grant for her studies on the
effects of trauma in schizophrenia and bipolar
disorders.
Post doc Martin Steen Tesli received Travel
Award, at World Congress of Psychiatric
Genetics, Copenhagen October 2014.
Prof. Ole A. Andreassen became new member
of National Academy of Science and Letters
NORMENT Annual report 2014 | 7
1
Happenings 2014
Lucca seminar:
In August, the clinical group’s postdocs participated in the annual writing seminar in Lucca, Tuscany, together
with the clinical research groups in Stavanger and Bergen. The seminar was the second inter-regional
seminar at this location, and further strengthened our ongoing inter-regional collaborations.
Illustration: Trine Vik Lagerberg, Carmen Simonsen and
Akiah Ottesen Berg (postdocs in the Clinical group) on their
bikes at the Lucca seminar.
Illustration: Early Saturday morning in
Lucca. Carmen Simonsen and Monica
Aas at work with their colleagues from
Bergen and Stavanger.
Illustration: Christine Demmo with her
poster at the Conference of the
International Society of Bipolar Disorders
in Seoul, March 2014.
Illustration: Petter Andreas Ringen and Levi Kvitland with
their posters at the Conference of the International Society
of Bipolar Disorders in Seoul, March 2014.
NORMENT Annual report 2014 |
8
2
The 22nd World Congress of Psychiatric Genetics in Copenhagen.
The 22nd World Congress of Psychiatric Genetics (WCPG) took place during 12-16 October 2014,
organized by a Scandinavian committee that included five of the NORMENT Core Researchers (Ole A.
Andreassen, Ingrid Melle, Vidar M. Steen, Srdjan Djurovic and Stephanie Le Hellard).
NORMENT researchers were responsible for a symposium on "the interplay between genetics and early
trauma in severe mental disorders" as well as a satellite symposium entitled "Leveraging Population
Registries and Biobanks for Neuropsychiatric Research: Experiences from the Nordic Countries and
Opportunities for the HORIZON 2020 Initiative of the European Union". In addition, NORMENT
contributed significantly to the scientific program through lectures and poster presentations".
Kenneth Hugdahl received The
Award for Outstanding
Research (Møbius Prize) from
the Research Council of
Norway.
Monica Aas received 2014
NARSAD Young Investigator
Grant for her studies on the
effects of trauma in
schizophrenia and bipolar
disorders.
NORMENT Annual report 2014 | 9
Srdjan Djurovic was hired as
professor II, at Clinical
Institute 2, University of
Bergen.
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4
NORMENT Annual Retreat 2014
NORMENT Annual Retreat took place in Oslo, September 1516. The program consisted of plenary lectures with updates,
new findings and ongoing projects, synergy workshops with
project planning, as well as poster sessions.
Visiting Scientific
Advisory Board (SAB)
In addition, there were presentations by our Scientific Advisory
Board, who also contributed with comments and feedback. A
total of 85 people participated, in an enthusiastic and
interactive atmosphere, and we had a successful annual
NORMENT dinner.
The conference took place at Quality Hotel Expo at Fornebu,
close to the fjord with easy transportation from city center and
airport.
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Michael Green

Terry Jernigan

Marcella Rietschel
Speakers at Annual Retreat
Scientific Advisory Board
1
Core Researchers
6
Senior Scientists
6
12
Post docs
PhD Students
1
NORMENT Annual report 2014 |
10
Core Researchers
NORMENT has organized the research into
interdisciplinary research groups with complementary
expertise. Each research group is led by a senior
researcher. NORMENT has eight Core Researchers.
NORMENT Annual report 2014 |
Translational Psychiatry
Achievements in 2014:
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Actively involved in a large international
consortium which led to the discovery of 108
risk genes for schizophrenia, and participated
in several discoveries of common gene
variants for psychiatric disorders.
Developed new statistical tools for improved
gene discovery in a range of polygenic
complex disorders.
Showed how polygenic factors are associated
with diagnostic groups and brain phenotypes.
Developed a team in translational psychiatry,
focusing on immune and cardiovascular
comorbidity.
Group leader:
Ole A. Andreassen,
Professor UiO, OUS
Group members:
Andrew Brown
Ingrid Dieset
Thomas Bjella
Aree Witoelar
Verena Zuber
Saurabh Srinivasan
Eva Zsuzsanna Hoseth
Yunpeng Wang
Sigrun Hope
Eivind Bakken
Francesco Bettella
Tuomo Mikael Marttunen
Ragni Mørch
Wen Li
Martin Tesli
Nils Eiel Steen
Terje Nærland
Ambitions for 2015:
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Finish the long range phasing of the
Norwegian population, and apply this
approach to severe mental illness.
Further improve the novel biotstatistical
tools, and apply them to core phenotypes
in psychiatry, focusing on brain imaging
and cross-disorder phenotypes.
Integrate our “biophysical psychiatry”
approach with clinical EEG measures.
Facilitate the investigations of immune
and cardiovascular comorbidity, and
multimodal imaging.
NORMENT Annual report 2014 |
Lars Tjelta Westlye
Daniel Quintana
Karolina Kauppi
Tobias Kaufmann
Nhat Trung Doan
Christine Lycke Brandt
Kristina Skåtun
Ingeborg Bolstad
12
Clinical Psychosis Research
Achievements in 2014:
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
Group leader:
Ingrid Melle,
Professor UiO, OUS.
Group members:
Trine Vik Lagerberg
Jannicke Fjæra Andresen
Idun Huflåtten
Camilla Bakkalia Büchmann
Carmen Simonsen
Erlend Gardsjord
Monica Aas
Mari Nerhus
. Færden
Ann
Petter Andreas Ringen
Akiah Ottesen Berg
Levi Røstad Kvitland
Marit Haram
Nasrettin Sömnez
Tiril Østefjells

The main focus for the research group is the
Centre’s Aim # 4 – the study of how genetic and
environmental factors influence course and
outcome in psychotic disorder.
The main focus in 2014 has been on the effect
of environmental risk factors and gene x
environment interactions on cross sectional
outcome, with a focus on early trauma,
migration and cannabis. This work is done in
close collaboration with other CR groups (in
particular molecular genetics, structural imaging
and Neurocognition) with several publications.
We have also finished the protocol for a longterm follow-up study of first episode patients.
Ambitions for 2015:

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
In December 2014 we received additional
external funding to launch the long-term
follow-up.
The ambition for 2015 is to start out the
first wave of follow-ups.
In addition, we will continue the work on
short-term effects of environmental risk
factors, including studies on interactions
with polygenetic risk scores in
collaboration with other CR groups in the
Centre.
NORMENT Annual report 2014 |
13
Psychiatric Molecular Genetics
Achievements in 2014:
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Several translational studies listed in
Research aims/deliverables published
and/or submitted
Inclusion of samples for stem cells project
and building up stem cells infrastructure
3 new postdocs recruited
New national /international collaborations
established
Group leader:
Srdjan Djurovic,
Professor OUS, UiB.
Group members:
Lavinia Athanasiu
Ida Elken Sønderby
Lars Hansson
Elin Inderhaug
Matthieu Vandenberghe
Agata Impellizzeri
Christian Melbø-Jørgensen
Kristine Kjeldal
Malik Mumtaz Hussain Taqi
Ambitions for 2015:
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Produce and further characterize
induced pluripotent stem cells and
induced neurons
Continue with disease modelling using
stem cell and cell cultures
Continuation of translational projects,
including deeper molecular
characterization and molecular
phenotyping
Continuation of work at international
collaboration (eg. CNV ENIGMA, PGC
BD, …)
NORMENT Annual report 2014 |
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Brain Imaging, Cognition
Achievements in 2014:


Group leader:
Kenneth Hugdahl, Professor
UiB
Group members:
Josef Bless
Maiken Brix
Alex Craven
Gerard Dwyer
Lars Ersland
Liv Falkenberg
Renate Grüner
Marco Hirnstein
Erik Johnsen
Bjørg Kocbach
Kristiina Kompus
Galyna Kovalchuk
Rune Kroken
Else-Marie Løberg
Susanne Passow
Igne Sinkevicute
Karsten Specht

First study on the relationship between
temporal and frontal lobe glutamate
concentrations and PANSS hallucination
scores published.
We have started the analysis of fMRI and
DTI data from the first wave of BP2
patients, with a focus on correlations with
auditory hallucinations.
We have developed a new smartphone
app for sampling of symptom-data in realtime, collaboration with Oslo CRs.
Ambitions for 2015:




Finish data analysis of the first wave BP2 patients,
especially mapping the temporal characteristics of
auditory hallucinations.
Run a first test of iPod app for sampling of data on
frequency and duration of auditory hallucinations,
collaborations with Oslo and Finland.
First attempt to analyze already acquired GABA
neurotransmitter concentrations from the same
brain areas as glutamate, and run against the
fluctuations of auditory hallucinations in the course
of a day.
Finish analysis of BAVQ data from 420 patients,
collected in Norway, Australia, and UK.
NORMENT Annual report 2014 |
15
Neurocognition
Achievements in 2014:



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Completed data collection for cognitive
remediation study and social cognition PhD
project.
Completed cognitive and functional outcome
protocol for long-term follow-up study of first
episode patients
PhD completed: Longitudinal neurocognitive
trajectories in first-episode psychosis:
Relationships between illness severity and
cognitive course
Two PhDs recruited to project on genetics of
attention and effort in healthy controls
The group has contributed to approximately 20
papers that were published in 2014
Ambitions for 2015:




Writing up of cognitive remediation study,
social cognitive post-doc project and
longitudinal first treatment bipolar study
Contribute to first wave of data collection
for long-term follow-up study
Continue development of new
computerized scoring software for social
and emotional processing in psychosis
Startup of data collection project on
genetics of attention and effort in healthy
controls
NORMENT Annual report 2014 | 16
Group leader:
Kjetil Sundet, Professor
UiO
Group members:
Torill Ueland
Anja Vaskinn
Thomas Espeseth
Vilja Bidtnes
Kristoffer Grimstad
Tale Moldestad
Beathe Haatveit
Christine Demmo
Jens Marius Halvorsen
June Lystad
Tone Hellvin
Structural MRI
Achievements in 2014:




Group leader:
Ingrid Agartz,
Professor UiO

Group members:
Kristine Engen
Tiril Pedersen Gurholt
Cecilie Bhandari
Hartberg
Unn Kristin H. Haukvik
Elisabeth Lange
Vera Lonning
Lynn Mørch-Johnsen
Stener Nerland
Ragnar Nesvåg
Kjetil Nordbø
Jørgensen
Thorny Olafsdottir
Runar Smelror
Erik Jönsson

Continued search for biological and environmental
correlates/effects to brain neuroanatomical changes.
Reported hippocampal subfields reductions in severe
psychoses and how perinatal asphyxia is related with
limbic structures in bipolar disorder.
New biomarkers: NMDA receptor antibodies, viral
serology.
Longitudinal neuroimaging – 1-year follow-up
finished.
Participated in genetic and imaging genetics
consortia for large scale association discovery.
Investigate for consistency of MR measures across
scanners.
Scandinavian multisite translational study on
adolescent psychosis now comprises three sites
(UiO and Karolinska Institutet and recent up-start in
Bergen)
Ambitions for 2015:




Detail the characterization of brain
phenotypes and clinical symptoms, use of
stimulants and pharmacological agents.
Implement use of app for sampling symptomdata in real time together with Hugdahl
Bergen group.
Characterize clinical sample for early trauma,
infection exposure and NMDA autoimmunity
and search for association with genetic risk
scores and brain phenotypes.
Expand adolescent early-onset psychosis to
more Scandinavian sites.
NORMENT Annual report 2014 |
17
Convergent functional genomics
Achievements in 2014:


Implemented new statistical tools for
gene-based association analysis and
allelic heterogeneity.
Identified genes and groups of genes
implicated in cognition and brain
imaging traits, both in NORMENTgrounded studies and through
participation in international consortia.
Group leader:
Stéphanie le Hellard,
Professor UiB
Group members:
Niladri Banerjee
Carla Fernandes
Sudheer Giddaluru
Tatiana Polushina
Anne Kristin Stavrum
Ghazal Zakeri
Ambitions for 2015:




Further develop gene-based studies for
allelic heterogeneity between psychiatric
disorders and relevant traits.
Finely map and characterize in silico the
implication of a few genomic loci
associated with schizophrenia.
Develop epigenetic studies for the
characterization of human-specific
methylated regions in complex traits and
gene by environment influence in
psychiatric traits.
Characterize the differential methylation
induced by cannabis exposure.
NORMENT Annual report 2014 |
18
Animal Models
Achievements in 2014:


Group leader:
Vidar M. Steen, Professor
UiB

Group members:
Hans-Richard Brattbakk
Jorunn S Bringsli
Inger H Duus
Kari M Ersland
Carla Fernandes
Rita Holdhus
Marianne Navdal
Silje Skrede
Christine Stansberg
Tomasz Stokowy
Identified genes and groups of genes
implicated in cognition and brain imaging
traits, both in NORMENT-grounded studies
and through participation in international
consortia.
Implemented methods for analysis of human
whole exome and whole genome sequencing
data, and identified novel disease genes.
Established long-acting formulation of
antipsychotic drugs as a new approach for
modelling metabolic adverse effects.
Ambitions for 2015:



Further explore the genetics and functional
genomics of schizophrenia-associated
genes involved in lipid metabolism,
immunity and synaptic signaling
Establish and improve experimental animal
models for studying brain myelination and
long-term effects of antipsychotic drugs
Further develop strategies and methods for
human gene annotation
NORMENT Annual report 2014 |
19
International Cooperation
The research requires close cooperation with leading research
environments, both national and international. The
researchers are participating in a series of international
networks, and have several bilateral research programs with
international institutions, both in the European Union and in
USA.
Marcella Rietschel,
Professor at
University of
Mannheim.
In addition to this, the Centre works actively to recruit
excellent researchers internationally.
The Centre facilitates the exchange of staff between the
participants and international collaborators. In 2014 we had 3
post docs abroad, and 4 international guest researchers were
associated with the Centre.
International Guest Researchers
Anders M. Dale and Wes Thompson, UCSD, USA; Sven
Cichon, Basel, Swizerland; Frank Larøi, Liege, Belgium.
Scientific Advisory Committee
NORMENT has established an Advisory Committee of
external scientific researchers. Their tasks are as follows:
Terry Jernigan,
Professor at
University of
California. San Diego.

Contribute to NORMENT’s research activity by
evaluating and advising on the activities within
each of the research groups of the Centre and
by acting as scientific advisors to the Centre
Director.

Contribute by giving an annual lecture at
postgraduate level.

Take an active part in NORMENT’s annual
Meetings.

Participate in preparing an annual written
evaluation with SWOT analysis.

Provide advice to the NORMENT leadership in
strategic decisions
Michael Foster
Green, Professor at
University of
California. Los
Angeles.
NORMENT Annual report 2014 |
20
New employees 2014
Anne-Kristin Stavrum. Ph.D in
Bio-informatics, UiB
Matthieu Vandenberghe,
Ph.D.Postdoctoral fellow
Aree Witeolar,
Ph.D.Postdoctoral fellow
Niladri Banerjee, Master in
Sciences, UiB
Ingrid Dieset, Ph.D. Associate
Professor
Sudheer Giddaluru. Ph.D in
Biomedicine, UiB
Erik Johnsen. Leader of the Norment
-associated Bergen Psychosis
Project
Ida Elken Sønderby, Ph.D.
Postdoctoral fellow
Erik Gunnar Jönsson,
Professor
Agata Impellizzeri. Ph.D.
Postdoctoral fellow
Tuomo Mikael Marttunen
Seyran Kahlili. Consultant
Frank Larøi. Psychologist and
Professor, UiB
Jeanette Haatveit, Admin.
Consultant
Jannicke Fjæra Anderssen,
Cand psychol. Ph.D Student
Malik Mumtaz Hussain Taqi
Scientist
Runar Smelror, Scientific
assistant
Linn Christin Norbom,
Scientific assistant
Wen Li, Scientist
Nhat Trung Doan, Ph.D in Medical
Imaging. Postdoctoral fellow
Daniel Quintana, Ph.D in
Psychology. Postdoctoral fellow
Tone Hellvin, Ph.D in
Psychology
Dag Alnæs, Ph.D Student
Sofie R. Aminoff., Ph.D.
Postdoctoral fellow
Tor Johannes Helleland, IT
assistant
Nina Chung Mathiesen
Sunniva Grimstad
Marlene Kristiansen Johre
NORMENT Annual report 2014 |
21
NORMENT Staff
Senior scientists, Professors and
Associate Professors
Erik Gunnar Jönsson, Professor
Erik Johnsen, Professor II
Ingrid Dieset, Associate Professor
Jan Ivar Røssberg, Professor II
Lars Ersland, Scientist, MR-physicist
Lars Tjelta Westlye, Associate Professor
Renate Grüner, Associate professor, MR physicist
Rene Westerhausen, Senior Scientist
Thomas Espeseth, Associate Professor
Unn Haukvik, Associate Professor
Research Fellows
Beathe Haatveit, MSc
Camilla Büchmann, Cand.psychol.
Carla Fernandes, MSc
Christine Demmo, Cand.psychol.
Christine Lycke Brandt, MSc
Dag Alnæs, Cand.psychol.
Elisabeth Lange, Cand.med.
Erlend S. Dørum, Cand. med.
Erlend Gardsjord, Cand.med.
Eva Hoseth, Cand.med.
Geneviève Richard, MA.psychol.
Helene Barder, Cand.psychol.
Ingeborg Bolstad, MSc
Jannicke Fjæra Anderssen, Cand.psychol.
Kjetil Nordbø Jørgensen, Cand.psychol.
Kristina Skåtun, MSc
Levi Kvitland, Cand.psychol.
Liv Falkenberg, MSc
Luiz Goulart, Cand.med.
Lynn Mørk Johnsen, Cand.med.
Maiken Brix, Cand.med.
Mari Nerhus, Cand.med.
Marit Haram, Cand.med.
Morten Mattingsdal, MSc
Nathalia Zak, Cand.med.
Niladri Banerjee, MSc
Saurabh Srinivasan, MSc
Siren Tønnessen, Cand.psychol.
Thorny Olafsdottir, Cand.med.
Tiril Østefjells, Cand.psychol.
Vera Lonning, Cand.med.
Post docs
Akiah Ottesen Berg, PhD in Psychology
Andrew Brown, PhD in Biostatistics
Anja Vaskinn, PhD in Psychology
Anne Kristine Stavrum, PhD in Informatics
Carmen Simonsen, PhD in Psychology
Cecilie Bhandari Hartberg, PhD in Medicine
Daniel Quintana, PhD in Psychology
Francesco Bettella, PhD in Biostatistics
Ida Sønderby, PhD in Molecular Genetics
Kari M. Ersland, PhD in Biomedicine
Karolina Kauppi, PhD in Medicine
Kristina Kompus, PhD in Psychology
Lavinia Athanasiu, PhD in Molecular Genetics
Martin Tesli, PhD in Medicine
Monica Aas, PhD in Psychology
Nhat Trung Doan, PhD in Medical Imaging
Silje Skrede, PhD in Biomedicine
Sudheer Giddaluru, PhD in Biostatistics
Tatiana Polushina, PhD in Applied mathematics
Tobias Kaufmann, PhD in Psychology
Tomasz Stokowy, PhD in Bioinformatics
Tone Hellvin, PhD in Psychology
Torbjørn Elvsåshagen, PhD in Medicine
Trine Vik Lagerberg, PhD in Psychology
Verena Zuber, PhD in Biostatistics
Yunpeng Wang, PhD in Biostatistics
Research Students
Claire L. Poppy, MA psychology
Hanne Smevik, MA psychology
Natalia Tesli, MA cognitive science
Nina C. Mathiesen, MA psychology
Synøve Kamøy, research student in medicine
Inger Duus, research student in medicine
Other Research Personell
Galyna Kovalchuk, MA, Research Assistant
Ghazal Zakeri, Research assistant
Idun Bernadotte Huflåtten, Cand Psychol
Kristoffer Grimstad, Cand.psychol.
Martina J. Lund, MA psychology
Tale Moldestad, Cand Pscyhol.
Vilja Bidtnes, Cand.psychol.
Christian Melbø-Jørgensen, Msc
Malik Mumtaz Hussain Taqi, PhD
Technical and Administrative
Positions
Alex Craven, Research technician
Bilal Safdar, Economist
Cecilie Evjen, Lab Assistant
Christine Stansberg, Senior Engineer
Eivind Bakken, Head Nurse
Elin Inderhaug, Bioengineer
Gerard Dwyer, Research Technician
Hans-Richard Brattbakk, Chief Engineer
Jeanette Haatveit, Admin. Consultant
Jorunn Bringsli, Chief Engineer
Kate Eli Frøland, Senior Excecutive Officer
Kristine Kjeldal, MSc
Lars Johan Hansson, MSc
Lena Stabell, Psychiatric Nurse
Line Gundersen, Nurse
Marianne Navdal, Lab Engineer
Ragnhild Bettina Storli, Admin. Consultant
Rita Holdhus, Chief Engineer
Runar Kristiansen, Database Assistant
Tanzeela Parveen, Medical Secretary
Thomas Bjella, Database Consultant
Vegard K. Lillevoll, IT Engineer
Øyvind Rustan, Scientific Assistant
NORMENT Annual report 2014 | 22
Activities 2014
Visits Abroad
International Cooperation
Post doc Andrew Brown holds a 50 % position at
the Sanger Institute (a genomics and genetics
research institute), UK.
University of Oxford, UK: Prof Steve Smith, Dr
Eugene P Duff, Dr Evangelos Roussos, Dr Gwen
Douaud
Post doc Yunpeng Wang is a visiting post doc
Multimodal Imaging Laboratory (MMIL), UCSD,
USA: Prof Anders M. Dale
Multimodal Imaging Laboratory, UCSD, USA: Prof
Anders M. Dale, Prof Wes Thompson
PhD Student Dag Alnæs, Post doc Tobias
Kaufmann and Associate Professor Lars T. Westlye
visited the FMRIB Centre, University of Oxford, in
November.
Max Planck UCL Centre for Computational
Psychiatry and Ageing Research, Berlin, GE: Dr
Douglas G. Garrett
deCODE, Iceland: Dr Hreinn Stefansson, Dr
Omar Gustafsson
Post doc Silje Skrede, March 20 – April 30:
research stay in the lab of prof. Miguel López,
CIMUS, University of Santiago de Compostela,
Spain.
Laboratory of Neuro Imaging
Keck School of
Medicine, University of Southern California, USA:
Dr Derrek Hibar, Prof Paul M Thompson
Post doc Martin Steen Tesli visited Institute of
Psychiatry, King's College London, in June
University of Copenhagen, DK: Associate
professor Randi Starrfelt, Professor Thomas
Werge
Post doc Verena Zuber visited UCSD, San Diego in
January and Karolinska, Stockholm in September.
Visits from Abroad
SCID, PANSS and DSM-V workshop – Joseph
Ventura, UCLA. He visited us in March 2nd-7th.
European Bipolar Research Network (ENBREC) –
from Paris, France visited us May 19th.
NORMENT Scientific Advisory Committee: Terry
Jernigan (San Diego, USA), Michael Green (Los
Angeles, USA) and Marcella Rietschel (Mannheim,
Germany) visited in September for NORMENT’s
annual gathering.
Brain Innovation BV, Maastricht, NL: Dr Ralph
Brecheisenl.
International Consortium on Hallucinations
Research (ICHR), coordinated from University of
Western Australia.
Karolinska Institutet, Sweden: Stockholm Child
and Adolescent Psychosis Study. Christina
Hultman, Epidemiology Genetics.
University of Oxford, UK. Angela Vincent
immunity, Guy Goodwin bipolar disorder.
Psychiatric Genomics Consortium (PGC). Pat
Sullivan UNC, USA, John Kelsoe UCSD, USA,
Mick O’Donovan Cardiff, UK.
Professor Anders M. Dale, Multi-Modal Imaging
Laboratory at University of California, San Diego
visited us from September 2-19 2014.
Bipolar Disorder Network. Paris, France. Bruno
Etain, Chantal Henry. Newcastle, UK, Jan Scott.
Dresden, Germany, Michael Bauer.
Associate Professor Alex Hoischen (Radboud
University Medical Center, the Netherlands) visited
us for two weeks in March and August 2014.
Institute of Psychiatry. London, UK. Robin Murray,
E. Vassos, M. DeForti, Psychosis research
NORMENT Annual report 2014 |
23
Selected presentations 2014
International presentations:
doc Monica Aas, 22nd World Congress of
Psychiatric Genetic, Copenhagen, Denmark.
“Trauma, Mental Health, and Undocumented
Migration.“ Post doc Akiah O. Berg.
European Society for Trauma and Dissociation
(ESTD) Conference, March, Copenhagen
“Can new psychiatric genetics findings facilitate
drug target identification?” Professor Ole A.
Andreassen, SCNP Copenhagen, Denmark
“Neurocognitive decrements are present in
intellectually superior schizophrenia.”
Post Doc Anja Vaskinn
Schizophrenia International Research Society,
Cognition Satellite meeting. Florence, Italy.
“MR in psychiatry” Professor Ingrid Agartz,
World Congress of the World Association of
Dynamic Psychiatry, St Petersburg, Lecture, MR
in psychiatry, St Petersburg, Russia.
“The relation between antipsychotic medication
history and ten-year outcome in first episode
psychosis”. Professor Ingrid Melle, 9th Early
Intervention in Psychosis Conference, Tokyo,
Japan.
“Perception of sounds that do not exist” Professor
Kenneth Hugdahl, Keynote speaker Nordic
Network Conference on Sounds, Music, and the
Brain, Helsinki, June.
“GWAS identifies common variants associated
with pharmacokinetics of psychotropic drugs”
Post doc, Lavinia Athanasiu, SCNP,
Copenhagen.
“Childhood Trauma as Risk Factor in Psychotic
Disorders- in Search of Mechanisms” Post doc
Monica Aas. The 4th Biennial Schizophrenia
International Research Society Conference,
Florence, Italy.
“Hypothalamus-pituitary-adrenal axis function in
psychosis and high risk for psychosis.” Post doc
Monica Aas, 44th ISPNE Conference, Sex and
Gender Across the Lifespan. Montreal, Canada.
“Additive association between childhood trauma
and bdnf val66met on volume of hippocampal
subfields- exploring the role of BDNF RNA. Post
“Beyond Bonferroni: Large Scale Inference for
Complex Disorders” Professor Ole A.
Andreassen, Lecture WCPG October 13.
“The Interplay between Genetics and Early
Trauma in Severe Mental Disorders”. Professor
Stephanie Le Hellard, Discussant, selected
symposium. XXIInd World Congress of
Psychiatric genetics, Copenhagen, Oct. 12-16.
“Processing speed and its components –
associations with age and indices of brain white
matter microstructure.” Senior scientist Thomas
Espeseth, the `Expert Workshop on Processing
Speed and Cognitive Ageing’. The Royal Society
of Edinburgh, April 30th.
“Indications of a dose - response relationship
between cannabis use and age at onset in
bipolar disorder.” Post doc Trine Vik Lagerberg,
16th Annual Conference of the International
Society for Bipolar Disorders, South Korea, Seoul.
National dissemination:
"Fysisk helse og mortalitet ved FEP tilstander,
hva vet vi og hva kan vi gjøre: Aktivitet motivasjon – helse". Post doc Andreas Ringen,
10. nasjonale TIPS-konferanse, Stavanger.
"Hvordan går det med personer med
psykoselidelser over tid - Hvor mange blir friske?"
Post doc Carmen Simonsen, i regi av
Fagforbundet, Gaustad sykehus - December.
“Heart rate variability in psychiatric Illness.” Post
doc Daniel S. Quintana.. Modum Bad Hospital,
Oslo, Norway.
«Hvorfor tidlig behandling? Kliniske implikasjoner
av en moderne psykoseforståelse» Professor
Ingrid Melle, Bergen tidlig psykose symposium,
Bergen.
NORMENT Annual report 2014 |
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"Neurocognition and occupational functioning in
schizophrenia spectrum disorders" PhD Student
June Lystad, Norsk Forum for Nevropsykiatri,
Oslo
"Kognitiv trening og arbeid". PhD Student June
Lystad, Verdensdagen for psykisk helse, Oslo
University College, Oslo.
nasjonale TIPS-konferansen, Schzofrenidagene
Stavanger.
"Polygenetics of attention and effort: Uncovering
brain circuit pathologies in schizophrenia". Senior
scientist Thomas Espeseth, seminar on
cognition in psychosis disorders, Engø, August
22nd, 2014.
“White matter meeting: everything you need and
want to know about white matter” Post doc Kari
Ersland, 06-07.02.Trondheim, Norway
“Miljømessige risikofaktorer ved psykoselidelser”
Post doc Trine Vik Lagerberg, ved Medisinsk
Fakultets 200 års jubileumsseminar for unge
forskere, Litteraturhuset.
“New technology in hallucinations research – app
methods” Professor Kenneth Hugdahl, Seminar
Speaker Nansen Neuroscience Network Meeting,
Oslo
"Psykosens anatomi - matcher hjernekartet til
terrenget?" Post doc Unn Kristin Haukvik,
Forskningsdagene 2014, Litteraturhuset, Oslo
"Nevropsykologi og kognitive funksjoner.
Implikasjoner for behandling og oppfølging ved
psykiske lidelser". Professor Kjetil S. Sundet,
Emnekurs i nevropsykiatri, LiPS (Leger i
Psykiatrisk Spesialisering), Bergen.
"Kartlegging av kognitiv funksjonssvikt".
Professor Kjetil Søren Sundet. Workshop 1:
Nevropsykologi. Den 10. nasjonale TIPSkonferansen, Schizofrenidagene, Stavanger.
"Sykdom og arv. Fra sjeldne genfeil til
folkesykdommer". Professor Vidar M Steen,
lecture at Dnlf-course on "Genetikk i klinisk
praksis", Gardermoen, February
"Metabolic effects of antipsychotic drugs: Some
bad guys and some good guys?" Professor Vidar
M Steen, Plenary lecture at Psykiatriveka 2014,
Bergen, March.
"Cannabis use in early bipolar disorder" Phd
Student Levi Røstad Kvitland Norsk forum for
nevropsykiatri, Oslo.
"Affektive lidelser - diagnose, symptom og
underliggende mekanismer". Professor Ole A.
Andreassen. Nasjonal konferanse akuttpsykiatri
Oslo 14. februar
"Forkortet livslengde ved psykoser. Årsaker og
intervensjoner". Professor Ole A. Andreassen.
Tidlig Psykose Symposium 2014, Bergen 2. juni
“Modelling blue-blocking treatment in rats.” Post
doc Silje Skrede, Psykiatriveka 2014, Bergen.
"Metabolske bivirkninger av antipsykotiske
medikamenter" Post doc Silje Skrede, Norsk
forening for rus- og avhengighetsmedisin (Nfram),
Bergen.
"Kognitiv trening for å øke funksjonsevnen ved
førstegangspsykose." Senior scientist Torill
Ueland, Tidlig intervensjon ved psykoser den 10.
NORMENT Annual report 2014 |
25
Disputations 2014
Aina Holmèn, Cand. psychol. (January 23, 2014)
“Neurocognition in early-onset schizophrenia with a particular focus on executive function”
Supervisors:
Bjørn Rishovd Rund
Ingrid Melle
Torbjørn Elvsåshagen, Cand. med. (May 19, 2014)
“A study of cortical structure and plasticity in bipolar II disorder.”
Supervisors:
Ulrik Fredrik Malt
Ole A Andreassen
Liv Eggset Falkenberg, MSc. (December 5, 2014)
«Neuronal underpinnings of healthy and dysfunctional cognitive control».
Supervisors:
Kenneth Hugdahl
Rene Westerhausen
Helene Barder, Cand.psychol. (June 23, 2014)
“Longitudinal neurocognitive trajectories in first-episode psychosis: Relationships between illness
severity and cognitive course.”
Supervisors:
Kjetil Sundet, Bjørn Rishovd Rund and Svein Friis
Erlend Mork, Cand. Psychol. (September 4,2014)
“Self-harm in patients with schizophrenia; risk factors and clinical characteristics.”
Supervisor: Lars Mehlum
Morten Mattingsdal, Cand. Scient. (September 2, 2014)
”Functional profiling of single-nucleotide polymorphisms associated with bipolar disorder.”
Supervisor:
Ole A. Andreassen
Srdjan Djurovic
Eivind Hovig
Unni Brattlien, Cand. Med. (May 28, 2014)
"The relevance of premorbid and prodromal phases in psychotic disorders”
Supervisors:
Merete Øie
Ingrid Melle
NORMENT Annual report 2014 |
26
NORMENT in the Media
Professor Kenneth Hugdahl at the University of
Bergen gets Research Council award for
excellence, Møbius Award, for his pioneering
research on the brain.
http://www.forskningsradet.no/no/Nyheter/Forsk
ningsrdet_deler_ut_tre_priser_i_dag/12540015
81512?lang=no
http://www.nrk.no/hordaland/far-pris-forforsking-pa-indre-stemmer-1.12021725
Seven Norment researchers participated in the
project "ENIGMA”, through "The ENIGMA Schizophrenia Working Group ".
http://enigma.ini.usc.edu/ongoing/enigmaschizophrenia-working-group/
Norwegian researchers have contributed to
discover over a hundred new genetic variants
that increase the risk of schizophrenia, of which
83 have not been previously described.
http://tidsskriftet.no/article/3238155
http://forskning.no/sykdommer/2014/07/over100-schizofreni-gener-funnet
Researchers have evaluated a mobile app for
self-training of auditory attention. The app is
designed to test the participants' ability to focus
their attention and to concentrate on one
specific sound via headphones. The results
show that training not only improved the
participants' achievements, it also had an
impact on how the brain handled the task.
http://journalofinternetinterventions.com/brainfitness-go-mobile-cognitive-training-effectsneural-plasticity/
Ole A. Andreassen is one of 15 new members
of the National Academy of Science and Letters,
Mathematics - and Natural academics class,
the group of medical sciences.
http://www.dnva.no/c40213/artikkel/vis.html?tid
=40214
Commentator Hilde Haugsgjerd writes in
Aftenposten March 2: "The journal Nature has
editorialized designated the present decade to
psychiatry decades. Internationally happens
advances in research on the brain, about genes
and the relationship between heredity and
environment for mental illness. Last year
opened Norwegian Centre for research on
mental disorders a collaboration between the
Universities of Bergen and Oslo and Oslo
University Hospital."
http://www.aftenposten.no/meninger/kommenta
rer/Et-lite-lys-i-tunnelen7486808.html#.UyBO03bKzIX
Ole A. Andreassen being interviewed in
connection with his lecturing under NevroNor’s
annual conference organized by the Research
Council.
http://www.forskningsradet.no/no/Nyheter/Pa_v
ei_inn_i_psykiatriens_tiar/1253991607534?WT.
mc_id=nyhetsbrev-ForskningsradetNorsk
“Be careful with cannabis!” Cannabis probably
plays a role in triggering the onset of psychotic
disorders. Caution with regard to cannabis use
should thus be exercised. Read the debate
article to Trine Vik Lagerberg, PhD and
specialist in clinical psychology, and Levi
Røstad Kvitland, fellow and psychologist,
Aftenposten Knowledge.
http://www.aftenposten.no/viten/Var-forsiktigmed-cannabis-7619359.html
Post doc Akiah O. Berg has written a blog post,
association for intercultural psychology.
http://www.psykologforeningen.no/Fag-ogprofesjon/Blogger/FIP-blogg/Det-ubehageligeblikket-innover
Andres M. Dale is a visiting researcher at
Norment and among the most successful
Norwegians abroad in category «academia ".
http://www.aftenposten.no/spesial/Hvemmener-du-fortjener-a-bli-karet-til-Norges-mestfremgangsrike-7531554.html#.U0m1CPmSySr
NORMENT Annual report 2014 |
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Publications 2014
1.
2.
3.
4.
5.
6.
7.
Aas M, Aminoff SR, Vik Lagerberg T, Etain B, Agartz
I, Andreassen OA, Melle I. Affective lability in
patients with bipolar disorders is associated with high
levels of childhood trauma. Psychiatry Res. 2014
Aug
Aas M, Dazzan P, Mondelli V, Melle I, Murray RM,
Pariante CM. A systematic review of cognitive
function in first-episode psychosis, including a
discussion on childhood trauma, stress, and
inflammation. Front Psychiatry. 2014 Jan
Aas M, Etain B, Bellivier F, Henry C, Lagerberg T,
Ringen A, Agartz I, Gard S, Kahn JP, Leboyer M,
Andreassen OA, Melle I. Additive effects of
childhood abuse and cannabis abuse on clinical
expressions of bipolar disorders. Psychol Med. 2014
Jun;44
Aas M, Haukvik UK, Djurovic S, Tesli M, Athanasiu
L, Bjella T, Hansson L, Cattaneo A, Agartz I,
Andreassen OA, Melle I. Interplay between
childhood trauma and BDNF val66met variants on
blood BDNF mRNA levels and on hippocampus
subfieldsvolumes in schizophrenia spectrum and
bipolar disorders. J Psychiatr Res. 2014Dec
Aas M, Pedersen G, Henry C, Bjella T, Bellivier F,
Leboyer M, Kahn JP, Cohen RF, Gard S, Aminoff
SR, Lagerberg TV, Andreassen OA, Melle I, Etain
B.Psychometric properties of the Affective Lability
Scale (54 and 18-item version) in patients with
bipolar disorder, first-degree relatives, and healthy
controls. J Affect Disord. 2014 Oct
Andreassen OA, Harbo HF, Wang Y, Thompson WK,
Schork AJ, Mattingsdal M, Zuber V, Bettella F, Ripke
S, Kelsoe JR, Kendler KS, O'Donovan MC, Sklar P;
The Psychiatric Genomics Consortium (PGC) Bipolar
Disorder and Schizophrenia Work Groups; The
International Multiple Sclerosis Genetics Consortium
(IMSGC), McEvoy LK, Desikan RS, Lie BA, Djurovic
S, Dale AM; The Psychiatric Genomics Consortium
PGC Bipolar Disorder and Schizophrenia Work
Groups; The International Multiple Sclerosis
Andreassen OA, McEvoy LK, Thompson WK, Wang
Y, Reppe S, Schork AJ, Zuber V, Barrett-Connor E,
Gautvik K, Aukrust P, Karlsen TH, Djurovic S,
Desikan RS, Dale AM; International Consortium for
Blood Pressure Genome-Wide Association Studies,
Genetic Factors for Osteoporosis Consortium.
Identifying common genetic variants in blood
pressure due to polygenic pleiotropy with associated
phenotypes. Hypertension. 2014 Apr
8.
Andreassen OA, Thompson WK, Dale AM. Boosting
the power of schizophrenia genetics by leveraging
new statistical tools. Schizophr Bull. 2014 Jan
9.
Andreassen OA, Zuber V, Thompson WK, Schork
AJ, Bettella F; PRACTICAL Consortium; CRUK
GWAS, Djurovic S, Desikan RS, Mills IG, Dale AM.
Shared common variants in prostate cancer and
blood lipids. Int J Epidemiol. 2014 Aug;43(4):120514.
10. Andreou D, Söderman E, Axelsson T, Sedvall GC,
Terenius L, Agartz I, Jönsson EG. Polymorphisms in
genes implicated in dopamine, serotonin and
noradrenalin metabolism suggest association with
cerebrospinal fluid monoamine metabolite
concentrations in psychosis. Behav Brain Funct.
2014 Jul
11. Badcock JC, Hugdahl K. A synthesis of evidence on
inhibitory control and auditory hallucinations based
on the Research Domain Criteria (RDoC) framework.
Front Hum Neurosci. 2014 Mar 26
12. Bauer M, Glenn T, Alda M, Andreassen OA,
Angelopoulos E, Ardau R, Baethge C, Bauer R,
Bellivier F, Belmaker RH, Berk M, Bjella TD, Bossini
L, Bersudsky Y,Cheung EY, Conell J, Del Zompo M,
Dodd S, Etain B, Fagiolini A, Frye MA, Fountoulakis
KN, Garneau-Fournier J, González-Pinto A, Harima
H, Hassel S, Relationship between sunlight and the
age of onset of bipolar disorder: an international
multisite study. J Affect Disord. 2014 Oct;167
13. Berg AO, Andreassen OA, Aminoff SR, Romm KL,
Hauff E, Melle I. The impact of immigration and
visible minority status on psychosis symptom profile.
Soc Psychiatry Psychiatr Epidemiol. 2014
Nov;49(11):1747-57.
14. Boraska V, Franklin CS, Floyd JA, Thornton LM,
Huckins LM, Southam L, Rayner NW, Tachmazidou
I, Klump KL, Treasure J, Lewis CM, Schmidt U,
Wellcome Trust Case Control Consortium 3, Estivill
X, Hinney A, Sullivan PF, Collier DA, Zeggini E, Bulik
CM. A genome wide association study of anorexia
nervosa. Mol Psychiatry. 2014 Oct;19
15. Brandt CL, Eichele T, Melle I, Sundet K, Server A,
Agartz I, Hugdahl K, Jensen J, Andreassen OA.
Working memory networks and activation patterns in
schizophrenia and bipolar disorder: comparison with
healthy controls. Br J Psychiatry. 2014
16. Bratlien U, Øie M, Haug E, Møller P,
Andreassen OA, Lien L, Melle I. Environmental
NORMENT Annual report 2014 |
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factors during adolescence associated with later
development of psychotic disorders - a nested casecontrol study. Psychiatry Res. 2014 Mar
17. Brown AA, Buil A, Viñuela A, Lappalainen T, Zheng
HF, Richard JB, Small KS, Spector TD, Dermitzakis
ET, Durbin R. Genetic interactions affecting human
gene expression identified by variance association
mapping. Elife. 2014 Apr 25;3:e01381
18. Buil A, Brown AA, Lappalainen T, Viñuela A, Davies
MN, Zheng HF, Richards JB, Glass D, Small KS,
Durbin R, Spector TD, Dermitzakis ET. Gene-gene
and gene-environment interactions detected by
transcriptome sequence analysis in twins. Nat
Genet.
19. Bull H, Ueland T, Lystad JU, Evensen S, Friis S,
Martinsen EW, Falkum E.Validation of the Work
Behavior Inventory. Nord J Psychiatry. 2014 Nov
13:1-7
20. Bøen E, Westlye LT, Elvsåshagen T, Hummelen B,
Hol PK, Boye B, Andersson S, Karterud S, Malt UF.
Regional cortical thinning may be a biological marker
for borderline personality disorder. Acta Psychiatr
Scand. 2014 Sep;130(3):193-204. doi:
10.1111/acps.12234. PMID: 24571788.
21. Bøen E, Westlye LT, Elvsåshagen T, Hummelen B,
Hol PK, Boye B, Andersson S, Karterud S, Malt UF.
Smaller stress-sensitive hippocampal subfields in
women with borderline personality disorder without
posttraumatic stress disorder. J Psychiatry Neurosci.
2014 Mar;3
22. Cappelen AW, Eichele T, Hugdahl K, Specht K,
Sørensen EØ, Tungodden B. Equity theory and fair
inequality: a neuroeconomic study. Proc Natl Acad
Sci U S A. 2014 Oct 28;111(43):15368-72.
23. Christoforou A, Espeseth T, Davies G, Fernandes
CP, Giddaluru S, Mattheisen M, Tenesa A, Harris
SE, Liewald DC, Payton A, Ollier W, Horan M,
Pendleton N, Haggarty P, Djurovic S, Herms S,
Hoffman P, Cichon S, Starr JM, Lundervold A,
Reinvang I, Steen VM, Deary IJ, Le Hellard S.
GWAS-based pathway analysis differentiates
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69. Norheim KB, Le Hellard S, Nordmark G, Harboe E,
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70. Nordvik JE, Walle KM, Nyberg CK, Fjell AM,
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71. Nurnberger JI Jr, Koller DL, Jung J, Edenberg HJ,
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84. Specht K, Baumgartner F, Stadler J, Hugdahl K,
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85. Steen NE, Methlie P, Lorentzen S, Dieset I, Aas M,
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NORMENT Annual report 2014 |
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spectrum disorders. J Psychiatr Res. 2014 May
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Funding
Actual financing of all academic activity at the center (in
thousand NOK)
2014
Funding agreed in the contract and reported in eRapport, but there
partly under different funding categories
Own financing
Proceeds from partner (s) to the host institution
Internal funding from partners (in kind)
Research Council (SFF-grant)
External project funds included in the contract
6 807
320
13 146
17 500
0
Total financing of the center as agreed in the contract
37 773
Financing projects with academic affiliation at the center
Other project funding from the Research Council
International project funding
Government project funding and other public financing
Private project funds and other private financing
8 426
0
18 578
5 640
Total funding from external projects
32 644
Financing overall academic activity
70 417
Personnel resources FTEs (summarized from the Centre staff tab)
Professors, researchers etc.
Doctoral fellows
Postdoctoral fellows
Visiting researchers
Technical / adm. staff
17,0
12,3
15,0
0,2
13,1
NORMENT Annual report 2014 |
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NORMENT Annual report 2014 |
35
NORMENT Annual report 2014 |
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