Molecular Pathology Division NEWSLETTER A me r i c a n A s s o c i a t i o n C l i n i c a l C h e mi s t r y f o r Message from the Chair Submitted by Greg Howe, Ph.D. Chair, MPD We are quickly approaching the start of the 2010 Annual AACC & Clinical Lab Expo (July 2529) at the Anaheim Convention Center in Anaheim, California. The annual meeting is an important venue for networking and learning details of the latest scientific and industry advances in laboratory medicine especially in molecular pathology. This year’s meeting is located in an area with which I have some familiarity. As an adolescent growing up in Southern California I spent a number of weekends in Orange County and have fond memories of enjoying various sites including Disneyland, Knott’s Berry Farm and the beach towns of Laguna Beach and Newport Beach. The most well known attraction is of course Disneyland which will be within walking distance of the convention center and most hotels, and provides a counterpoint to the more serious activities going on at the annual meeting. There are also many other attractions nearby, however some will require a car, but are well worth the effort. Since I frequently return to the area I always try to visit sites that have a special appeal to me including the Mission San Juan Capistrano, the Queen Mary in Long Beach, and the always inspiring Huntington Gardens in San Marino, and the Getty Museums which combine outdoor gardens and art. For your less cultured instincts you can catch a baseball game at the Angel Stadium of Anaheim or shop at the Anaheim GardenWalk, which is also within walking distance, or Fashion Island in Newport Beach. As you can see there are many opportunities to take a break from the meeting, but don’t forget to participate in several events developed by MPD which are described below. MPD Board of Directors Meeting. Tuesday, July 27th, 2010; 3:30-4:30pm, Hilton Anaheim Hotel (Santa Monica room) MPD Annual General Membership Meeting. Tuesday, July 27th, 2010; 4:30pm5:30pm, Hilton Anaheim Hotel (Santa Monica room) Joint MPD/Pediatric Maternal-Fetal/ Industry/Clinical Translational Divisional Award and Mixer. Tuesday, July 27th, 2010; 6:00pm-8:00pm, Hilton Anaheim Hotel (Carmel room) MPD 2010 Awards Finalists: The MPD Science and Education Committee (SEC), chaired by Jerry Yeo, has reviewed the submitted abstracts for consideration, and has selected 2-3 finalists in each category to present their respective posters on Monday, July 26, 12.00pm- 1.30pm at the Hilton Anaheim Hotel (Manhattan Hall). Based on the authors’ presentations a winner in each category will be chosen by the committee. The finalists in each category are as listed below in the SEC report. More details of events of interest to MPD members are also described elsewhere below. So please take a look at the rest of the newsletter. Enjoy your time at the meeting and I hope to see you there. Volume 22, Issue 2 Summer 2010 Inside this issue: MPD 2010 Award Finalists 2 Highlighted Annual Meeting Sessions 3 MPD Events at Annual Meeting 5 AACC Molecular Pathology Division Newsletter Volume 22, Issue 2 Summer, 2010 Page 2 MPD 2010 Award Finalists Submitted by K.T. Jerry Yeo, Ph.D., Chair, Science and Education Committee, MPD The MPD Science and Education Committee (SEC) recently reviewed and selected the following AACC 2010 abstract finalists in each category listed below. Each finalist listed below will present their poster to the committee on Monday, July 26 at 12 noon at the venue listed below. The committee will then choose a winner in each category. Failure to appear at this judging will automatically disqualify the finalist from being considered for the award. The decision by the SEC is final and no appeal will be entertained. MPD Poster Award Finalists Oral Presentation Monday 7/26/2010 12:00 pm 1:30 pm Hilton Anaheim Hotel Manhattan Outstanding Research Award Finalists C-29: RHN. van Schaik et al. Cyp2C19 *2 allele carriers have longer time to treatment failure on Tamoxifen therapy in advanced breast cancer treatment. D-117: Y. Su et al. Levels and clinical significance of circulating endothelial progenitor cells in human ovarian cancer. Young Investigator Award Finalists B-98: L. Zhang et. al. Application of Genotype MTBDRplus in rapid detection of the Mycobacterium tuberculosis complex as well as its resistance to isoniazid and rifampin in a high volume laboratory in Southern China. E-34: SM. Shawky et al. Rapid detection of unamplified HCV RNA in clinical specimens using unmodified gold nanoparticles. Student Award Finalists B-124: J. He et al. Genetic variants of transcription nuclear factor (NF)-kappaB and atopic diseases. B-126: RP. Ola et al. Acetylator phenotype and genotype polymorphisms of N-acetyltransferase-2 in Indian patients on anti-tubercular treatment. B-134: D. French et al. Comparison of DNA sequencing and Autogenomics Infiniti® assay for KRAS and BRAF mutation testing in cancer. All finalists should e-mail Jerry Yeo, Chair of SEC, at [email protected] by July 19, 2010 to confirm that they plan to appear for the oral presentation as indicated above. Congratulations to all finalists! AACC Molecular Pathology Division Newsletter Volume 22, Issue 2 Summer, 2010 Page 3 AACC Annual Meeting 2010 Sessions of Potential Interest to MPD Members *Programs developed in cooperation with the MPD Sunday, July 25, 2009 • Applying Personalized Medicine to Pharmaceutical Delivery and Management. Felix Frueh, PhD, Medco, Bethesda, MD • Where is the (Persibak) Information to Drive Personalized Medicine? Samuel (Sandy) Aronson, MA, Partners HealthCare Center for Personalized Genetic Medicine, Cambridge, MA • The Personalized Hospital: Why El Camino Hospital Is Taking a Giant (Genetic) Leap Forward. Paul Billings, MD, PhD, El Camino Hospital Foundation, Berkeley, CA 1:30 p.m.—4:00 p.m. Afternoon Short Course 191008 The Base-ics of Nucleic Acid Testing, Moderator Gregory Tsongalis, PhD, HCLD, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Norris Cotton Cancer Center, Lebanon, NH Afternoon Speakers • • Introduction to Nucleic Acid Biochemistry and Molecular Diagnostic Technologies. Gregory Tsongalis, PhD, HCLD, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Norris Cotton Cancer Center, Lebanon, NH Molecular Technologies and Their Clinical Applications. Andrea Ferreira-Gonzalez, PhD, Virginia Commonwealth University, Richmond 6:45 p.m—8:00 p.m. Opening Mixer, Anaheim Marriott Hotel Monday, July 26, 2009 10:30 a.m.—12:00 p.m., Morning Interactive Workshop 22110 Legal Liability for Not doing PGx Testing: A Temporarily Theoretical Discussion. Moderator Jerry Goldsmith, Sandpiper Strategies, Washington, DC Morning Speakers • The Laboratory's Role in Avoiding Potential Liability for ADRs. Gregory Tsongalis, PhD, HCLD, Dartmouth Medical School, DartmouthHitchcock Medical Center, Norris Cotton Cancer Center, Lebanon, NH • Legal Perspectives on Liability for ADRs. Mollie Roth, JD, Chandler, AZ, United States 7:30 a.m. – 8:30 a.m., Brown Bag Sessions 42107 A Fully Automated Platform for Molecular Diagnostics, Claudine Lefferts, Ph.D., Dartmouth-Hitchcock Medical Center, Lebanon, NH 42111 Hepatitis C Virus: Epidemiology, Diagnosis, and Patient Management, Peter Chour, Ph.D., DABCC, FACB, Quest Diagnostics Nichols Institute, Chantilly, VA. 10:30 a.m.—5:00 p.m., Full day Symposium 32301 Personalized Medicine: Understanding the Environment, Moderator Michael Stocum, MS, Personalized Medicine Partners, Raleigh, NC, United States Morning Speakers • A Regulatory Perspective: Where FDA is Taking Personalized Medicine. Federico Goodsaid, PhD, U.S. Food & Drug Administration, Silver Spring • Personalized Medicine: The Developers, Stakeholders and Beneficiaries. Michael Stocum, MS, Personalized Medicine Partners, Raleigh, NC, United States Afternoon Speakers 12:30—1:30 p.m., Brown Bag Sessions 52207 A Fully Automated Platform for Molecular Diagnostics, Claudine Lefferts, Ph.D., Dartmouth-Hitchcock Medical Center, Lebanon, NH 2:30 p.m. – 5:00 p.m., Afternoon Short Course 72219 Molecular Diagnostic Testing: Practical Concerns and Good Laboratory Practices*, Moderator Barbara Zehnbauer, PhD, FACMG, Centers for Disease Control and Prevention, Atlanta GA Afternoon Speakers • A New CDC Guideline for Good Laboratory Practices for Molecular Genetic Testing – What AACC Molecular Pathology Division Newsletter Volume 22, Issue 2 Summer, 2010 Page 4 Laboratories Should Know and Why? Bin Chen, PhD, FACMG, CDC, Atlanta, GA 10:30 a.m. – 12:00 p.m., Morning Symposium • Reference Materials for Genetic Testing (and Where Can You Find Them?). Lisa Kalman, PhD, CDC, Atlanta, GA 34103 Personalized Medicine in Oncology: Optimization of Chemotherapy. Moderator William Clarke, PhD, MBA, DABCC, Johns Hopkins Medical Institutions, Baltimore, MD • Standardizing Laboratory Practices in Molecular Diagnostic Testing – Consider the Testing AND the Laboratory-Clinician Interfaces. Shahram Shahangian, PhD, MS, DABCC, FACB, US Centers for Disease Control and Prevention (CDC), Atlanta, GA Tuesday, July 27, 2009 Morning Speakers • Pharmacokinetically-Guided Therapy in Cancer: Current Practice and Developing Opportunities. Salvatore Salamone, PhD, Saladax Biomedical Inc, Bethlehem, PA • Pharmacogenetics of Chemotherapy: Cytochrome P450s, Drug Metabolizing Enzymes, and Beyond. Alex Rai, PhD, DABCC, FACB, Columbia University Medical Center, New York, NY 7:30 a.m. – 8:30 a.m., Brown Bag Sessions 43104 Testing for Alpha 1-Antitrypsin Deficiency, Joshua Bornhorst, PhD, University of Arkansas for Medical Sciences, Little Rock 43103 Using Laboratory Algorithms for the Diagnosis of Celiac Disease, Melissa Snyder, PhD, Mayo Foundation, Rochester, MN 43125 A Fully Automated Platform for Molecular Diagnostics, Claudine Lefferts, Ph.D., Dartmouth-Hitchcock Medical Center, Lebanon, NH 12:30—1:30 p.m., Brown Bag Sessions 54206 MicroRNA in Clinical Diagnostics: Hype or Hope? Alicia Algeciras-Schimnich, Ph.D., DABCC, Mayo Clinic, Rochester, MN 2:30 p.m. – 5:00 p.m., Afternoon Symposium 34209 Infectious Disease Testing: How Traditional Techniques Complement Molecular Approaches, Moderator Susan Sharp, PhD, Kaiser Permanente-NW, Portland, OR Afternoon Speakers • Detecting Clostridium difficile colitis: What, When, Why? Susan Sharp, PhD, Kaiser Permanente-NW, Portland, OR • Molecular Screening for MRSA: Impact on Patient Care Peter Gilligan, PhD, UNC Hospitals, Chapel Hill ter, MN • 53225 A Fully Automated Platform for Molecular Diagnostics, Claudine Lefferts, Ph.D., Dartmouth-Hitchcock Medical Center, Lebanon, NH Rapid Influenza Antigen Testing: Helpful or Harmful? Kimberle Chapin, MD, D(ABMM), FCAP, Lifespan Academic Medical Centers, Providence, RI • The Future of Tuberculosis Testing Ellen Jo Baron, PhD, Diplomate, Am.Board Med. Micro., Stanford University Medical Center, Palo Alto, CA • Food-Borne Pathogens: Why Molecular Testing is Not Enough • Roberta Carey, PhD, Centers for Disease Control and Prevention, Atlanta, GA 12:30—1:30 p.m., Brown Bag Sessions 53204 Testing for Alpha 1-Antitrypsin Deficiency, Joshua Bornhorst, PhD, University of Arkansas for Medical Sciences, Little Rock 53203 Using Laboratory Algorithms for the Diagnosis of Celiac Disease, Melissa Snyder, PhD, Mayo Foundation, Roches- Wednesday, July 28, 2009 7:30 a.m. – 8:30 a.m., Brown Bag Sessions 44106 MicroRNA in Clinical Diagnostics: Hype or Hope? Alicia Algeciras-Schimnich, Ph.D., DABCC, Mayo Clinic, Rochester, MN AACC Molecular Pathology Division Newsletter Volume 22, Issue 2 Summer, 2010 Page 5 2:30 p.m. – 5:00 p.m., Afternoon Short Course 74214 Personalized Medicine in Pediatric Neurology Clinical Pharmacogenetics in the Treatment of New Onset Childhood Epilepsy*, Moderator Stanley Lo, PhD, DABCC, FACB, Childrens Hospital of Wisconsin/Medical College of Wisconsin, Milwaukee Afternoon Speakers • Clinical Pharmacogenetic Test Implementation - A Team-Oriented Approach. Stanley Lo, PhD, DABCC, FACB, Childrens Hospital of Wisconsin/Medical College of Wisconsin, Milwaukee • Clinical Pharmacogenetic Testing in the Treatment of New Onset Childhood Epilepsy Charles Marcuccilli, MD, PhD, Medical College of Wisconsin & Children's Hospital of Wisconsin, Milwaukee • Method Selection, Validation and Quality Control for Clinical Pharmacogenetics Tara Sander, PhD, Children's Hospital of Wisconsin, Milwaukee Thursday, July 29, 2009 9:30 a.m. – 12:00 p.m., Morning Symposium 35101 Pharmacogenomics in Clinical Practice, Moderator Gregory Tsongalis, PhD, HCLD, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Norris Cotton Cancer Center, Lebanon, NH Morning Speakers • Targeted Therapies in the Management of Human Cancer..Gregory Tsongalis, PhD, HCLD, Dartmouth Medical School, DartmouthHitchcock Medical Center, Norris Cotton Cancer Center, Lebanon, NH • Tamoxifen: A New Understanding of an Old Drug. Karen Weck, MD, University of North Carolina School of Medicine, Chapel Hill • Pharmacogenomics in the Management of Cardiovascular Disease. Alan Wu, PhD, DABCC, FACB, University of California at San Francisco • Germline Variants Affecting Treatment for Infectious Disease. Elaine Lyon, PhD, ARUP Laboratories/U of Utah, Salt Lake City M a r k Yo u r Calendars! MPD Events at AACC Annual Meeting Monday, July 26, 12:001:30 p.m. MPD 2010 Awards Finalists Poster Presentations, Hilton Anaheim Hotel (Manhattan Hall) Tuesday, July 27, 3:304:30 p.m., MPD Board of Directors Meeting, Hilton Anaheim Hotel (Santa Monica room) Tuesday, July 27, 4:305:30 p.m., MPD General Membership Meeting, Hilton Anaheim Hotel (Santa Monica room) Tuesday, July 27, 6:008:00 p.m., Joint MPD/ Pediatric Maternal-Fetal/ Industry/Clinical Translational Divisional Award and Mixer, Hilton Anaheim Hotel (Carmel room) (Awards will be presented during this event) AACC Molecular Pathology Division Newsletter Summer, 2010 Volume 22, Issue 2 19th Annual Symposium Clinical Applications of Genomic Medicine Keynote Address: Epigenetic Alterations in Cancer and Their Clinical Implications - Gangning Liang, M.D., Ph.D. Additional discussion in the topics of: • • • Myeloproliferative Neoplasms HPV and Tuberculosis Testing Molecular Epidemiology and Test Validation $120 per person/$40 per session (Physicians, bioscientists, Ph.D.s, scientific/research staff) $60 per person/$20 per session (Fellows, residents, technologists, students) Visit our website at www.beaumont.edu/dnasymposium for more details. Page 6 AACC Molecular Pathology Division Newsletter Volume 22, Issue 2 Summer, 2010 Page 7 AACC Molecular Pathology Division Newsletter Summer, 2010 Volume 22, Issue 2 Page 8 2010 Division Executive Committee Nominating Committee: Chair: John Greg Howe, Ph.D. Department of Laboratory Medicine Yale University of Medicine 333 Cedar Street New Haven, CT 06520-8035 (203) 737-4237 [email protected] Newsletter Editor: Past Chair: Kiang-Teck Jerry Yeo, Ph.D. University of Chicago Department of Pathology (MC 0004) 5841 S. Maryland Avenue Chicago , IL 60637-1470 (773) 702-1318 [email protected] Internet Coordinator: Loralie Langman, Ph.D. Laboratory Medicine and Pathology Mayo Clinic, Hilton 730 200 First Street SW Rochester, MN 55905 (507) 284 8408 [email protected] Chair-Elect: Alex Jaideep Rai, Ph.D. Memorial Sloan Kettering Cancer Center Clinical Laboratories 1275 York Avenue, Box 88 New York, NY 10021 (212) 639-5599 [email protected] Membership Chair: Stan Kwang, Ph.D. Clinical Diag Group-Quality Systems Bio-Rad Laboratories 9500 Jeronimo Road Irvine, CA 92618 (949) 598-1254 [email protected] Secretary: Alex Jaideep Rai, Ph.D. Memorial Sloan Kettering Cancer Center Clinical Laboratories 1275 York Avenue, Box 88 New York, NY 10021 (212) 639-5599 [email protected] Events Coordinator: Nikolina Babic, Ph.D. University of Chicago Department of Pathology 5841 S. Maryland Avenue Chicago , IL 60637-1470 (773) 702-1318 [email protected] Treasurer: Linnea Baudhuin, Ph.D. Laboratory Medicine and Pathology Mayo Clinic, Hilton 402 200 First St SW Rochester, MN 55905 (507)538-0078 [email protected] Members-at-Large: Tom Hayhurst Pathwork Diagnostics, Inc. 2 North First Street San Jose, CA 95113 (925) 461-4358 [email protected] Nominating Committee Chair: Bonny Lewis Van, Ph.D. Van Consulting, LLC 6085 Walnut Ct Brownsburg, IN 46112 317-504-4165 [email protected] Loralie Langman, Ph.D. Laboratory Medicine and Pathology Mayo Clinic, Hilton 730 200 First Street SW Rochester, MN 55905 (507) 284 8408 [email protected] Alan H.B. Wu, Ph.D. UC-San Francisco Laboratory Medicine 1001 Potrero Avenue, Room 2M27 San Francisco, CA 94110 (415) 206-3540 wualan@[email protected] Neal Ian Lindeman Brigham and Women’s Hospital Pathology 75 Francis Street Amory 2-217d Boston, MA 02115 (617) 732-6790 [email protected] Other Division Contacts: Linnea Baudhuin, Ph.D. Laboratory Medicine and Pathology Mayo Clinic, Hilton 402 200 First St SW Rochester, MN 55905 (507)538-0078 [email protected] Liaison to CAP/ACMG Molecular and Biochemical Genetics Resources Committee: Ingo Kampa, Ph.D. The Valley Hospital Pathology & Laboratory Medicine 223 North Van Dien Avenue Ridgewood, NJ 07450-2736 (201) 447-8235 [email protected] Barbara Zehnbauer, Ph.D. Washington University Pathology/Lab Medicine 660 South Euclid Avenue, Box 8118 Saint Louis, MO 63110 (314) 454-8609 [email protected] Liaison to CAP Molecular Pathology Committee: Larry Silverman, Ph.D. 3430 Coleman Drive Charlottesville, VA 22901 (434) 243-2957 [email protected] Liaison to AMP: Jeanne Carr, Ph.D. St. Jude Children’s Res. Hospital Technical Dir., Molecular Micro. Memphis, TN (901) 495-5345 [email protected]