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BETTY TSUEI, MD, FACS, FCCM
UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE
DEPARTMENT OF SURGERY
PERSONAL INFORMATION
OFFICE ADDRESS
Department of Surgery
University of Cincinnati College of Medicine
231 Albert Sabin Way
P.O. Box 670558
Cincinnati, OH 45267-0558
TELEPHONE NUMBERS
Office:
Fax:
E-mail:
(513) 558-5661
(513) 558-3136
[email protected]
UNDERGRADUATE EDUCATION
1981-1985
Princeton University
Department of Physics
Princeton, NJ
B.A. - 1985
MEDICAL EDUCATION
1985-1989
University of Cincinnati
College of Medicine
Cincinnati, OH
M.D. – 1989 (June 11, 1989)
SURGICAL EDUCATION
1989 - 1997
Resident
University of Cincinnati
Department of Surgery
Cincinnati, OH
1997 - 1998
Fellow
Critical Care and Trauma
University of Cincinnati
Department of Surgery
Cincinnati, OH
BOARD CERTIFICATION
1999
American Board of Surgery
Surgery - #44758
Initial Certification: December 14, 1999
Recertification: December 6, 2007
2001
American Board of Surgery
Surgical Critical Care – #1935
Initial Certification: October 19, 2001
Recertification: October 1, 2010
Betty J. Tsuei, MD
Curriculum Vitae
2
LICENSURE
Ohio
Kentucky
35-06-7186 (7-14-94 - present)
34597 (7-15-98 - present)
HOSPITAL PRIVELEGES
University Hospital, Cincinnati, OH
The Christ Hospital, Cincinnati, OH
Jewish Hospital, Cincinnati, OH
Drake Hospital, Cincinnati, OH
PRESENT POSITIONS
September 2012 – present
Professor, Department of Surgery
University of Cincinnati College of Medicine
Cincinnati, OH
October 2004 – present
Associate Professor, Department of Surgery
University of Cincinnati College of Medicine
Cincinnati, OH
October 2004 – present
Director, Surgical Intensive Care Unit
University Hospital
Cincinnati, OH
January 2005 - present
Director, Surgical Critical Care Fellowship
University Hospital
Cincinnati, OH
March 2005 – present
Adjunct Faculty
United States Air Force
School of Aerospace Medicine
PREVIOUS POSITIONS
August 1998 - September 2004
Assistant Professor, Department of Surgery
Trauma Surgery and Surgical Critical Care Services
University of Kentucky Medical Center,
Lexington, KY
August 1998 - September 2004
Consultant, Nutrition Support Service,
University of Kentucky Medical Center,
Lexington, KY
January 1999 - September 2004
Education Director – Trauma and Critical Care
University of Kentucky
Lexington, KY
July 2000 - September 2004
Associate Program Director
Critical Care Fellowship
University of Kentucky
Department of Surgery
July 1997 – June 1998
Clinical Instructor and Voluntary Staff
Department of Surgery
University Hospital
Betty J. Tsuei, MD
Curriculum Vitae
3
Cincinnati, OH
AWARDS
1986
Student Summer Research Program award
University of Cincinnati - College of Medicine
1994
Resident Research Award
University of Cincinnati - Department of Surgery
1995
Resident Research Award
University of Washington - Department of Surgery
1996
Resident teaching award
University of Cincinnati - Department of Surgery
1997
Resident teaching award
University of Cincinnati - Department of Surgery
2002
Ward O. Griffen Surgery Teaching Award
University of Kentucky - Department of Surgery
2006
SCCM Research Citation Finalist: SCCM Research
Citation Finalist. Effect of a patient focused analgesiasedation protocol without daily interruption in a surgical
intensive care unit.
2007
Anthem's Hospital Quality Program Meritorious winner.
The development and evaluation of a patient-focused
sedation protocol in a surgical/trauma intensive care
unit.
PROFESSIONAL SOCIETIES
1996 – present
1998 – present
2003 – present
2005 – present
2009 - present
2009 – present
2010 - present
American College of Surgeons – fellow (2004)
Society of Critical Care Medicine – fellow (2007)
Job Descriptions Committee (2010-present)
Eastern Association for the Surgery of Trauma
Publications committee (2003-2005)
Ohio Chapter of American College of Surgeons
Association for Academic Surgery
Central Surgical Association
Membership Committee (2011-present)
Society of University Surgeons
COMMITTEES
2000 – 2004
Surgical Education Committee
University of Kentucky
2002
Liaison Committee on Medical Education
University of Kentucky
Site review – participant
2003
Graduate Medical Education – Internal Residency
Review Committee
University of Kentucky
Betty J. Tsuei, MD
Curriculum Vitae
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Urology review – participant
2003 – 2005
Eastern Association for the Surgery of Trauma
Publications committee
2003 – 2004
American College of Surgeons
Kentucky Committee on Trauma
2004
College of Medicine
Clinical Performance Exam Committee
University of Kentucky
2004
Infection Control Committee
University of Kentucky
2004
Intensive Care Committee
University of Kentucky
2005
ICU Planning Committee
University of Cincinnati
2005
Rapid Response Team Committee
University of Cincinnati
2005
SICU Management Committee
University of Cincinnati
2005
Surgical Infection Protocol Committee
University of Cincinnati
2005 – 2006
Surgical Progressive Care Planning Committee
University of Cincinnati
2005 – 2007
SICU Unit Based Design Team - chair
University of Cincinnati
2005 – 2007
Alliance Wide Critical Care
University of Cincinnati
2005 – present
American College of Surgeons
Ohio Committee on Trauma
2005 – 2009
CPR Committee
University of Cincinnati
2005 – 2009
Transfusion Committee
University of Cincinnati
2005 – present
Special Care Committee
University of Cincinnati
2005 – present
SICU Protocol Committee - chair
University of Cincinnati
2006 – 2009
Extraordinary Performance Committee
University of Cincinnati
Betty J. Tsuei, MD
Curriculum Vitae
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2009 – 2011
Medical Executive Committee
University Hospital, Cincinnati OH
2010 – present
Lab Advisory Committee
University Hospital, Cincinnati, OH
2010 – present
Critical Care Task Force
University Hospital, Cincinnati OH
Metrics subcommittee - chair
2010 – present
Job Descriptions Committee
Society of Critical Care Medicine
2011 – present
Membership Committee
Central Surgical Association
2012 – present
Critical Care Task Force – Special Care Committee chair
University Hospital
OTHER SIGNIFICANT SCHOLARLY, RESEARCH OR ADMINISTRATIVE EXPERIENCE
2004 - present
2005 - present
June – Dec 2006
2006
2008 – present
2009 – present
2010 – present
2011 – present
Director, Surgical Intensive Care Unit
University Hospital - Cincinnati, OH
Director, Surgical Critical Care Fellowship
University Hospital - Cincinnati, OH
Assessment of the pregnant trauma patient. Among the
10 most downloaded articles on Science Direct.
American Journal of Obstetrics and Gynecology reviewer
Journal of Trauma – reviewer
Society of Critical Care Medicine – reviewer
Annals of Surgery - reviewer
Respiratory Care - reviewer
OTHER EDUCATIONAL ACTIVITY
1997 - 1998
Instructor
University of Cincinnati
Department of Surgery
1997 - 1998
Instructor - Gross Anatomy – thorax and abdomen
University of Cincinnati
Department of Anatomy
1999 – 2004
Education Director –Trauma and Critical Care
University of Kentucky
Lexington, KY
1998 – present
Advanced Trauma Life Support
Instructor
2010
American Board of Surgery
SCORE curriculum development – critical care
Betty J. Tsuei, MD
Curriculum Vitae
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RESEARCH – active
Penetrating neck injuries
2009 – present
Delirium in the SICU
2008 – present
Assessing outcome from concomitant blunt cerebrovascular and cervical spine injury
2009 – present
RESEARCH – submitted
USAF 711 Human Performance Wing – $125,000
Primary Investigators: Betty J. Tsuei and Travis Gerlach
Noninvasive hemoglobin monitoring in patients with suspected hemorrhage
IRB approval from University of Cincinnati, awaiting USAF IRB approval
RESEARCH – completed
Wyeth Pharmaceuticals
Sub-Investigator: Betty J. Tsuei
“A multicenter, randomized, double-blind, placebo-controlled, parallel-group study of intravenous
methyltrexone (MOA-728) for the treatment of postoperative ileus after ventral hernia repair”
August 15, 2007 – 2009
Department of Surgery
Primary Investigator: Betty J. Tsuei
“ARDSnet protocol vs. the open lung approach for the ventilatory management of severe,
established ARDS: a global randomized controlled trial”
February 2007 – 2009
Office of Naval Research
Sub-Investigator: Betty J. Tsuei, M.D.
“MCTV (Marine Corps Transport Ventilator) clinical and pre-clinical evaluation”
April 7, 2005 - 2010
AMGEN
Primary Investigator: Betty J. Tsuei
“A prospective study to evaluate the erythropoetic responsiveness associated with once weekly
administration of Aranesp in patients admitted to the ICU”
September 2006 – November 2007
Ohio Department of Public Safety
Emergency Medical Services Division
Primary Investigator: Betty J. Tsuei
“A prospective study utilizing the adult METI simulator in the evaluation of airway management
by EMS personnel wearing protective gear”
July 2006 – July 2007
Discovery Labs
Sub-Investigator: Betty J. Tsuei, M.D.
“A multi-center, randomized, controlled trial comparing the safety and effectiveness of Surfaxin
(lucinactant) delivered via broncho-pulmonary segmental lavage to standard of care in patients
with acute respiratory distress syndrome (ARDS)”
June 25, 2005 - December 2006
Betty J. Tsuei, MD
Curriculum Vitae
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Peninsula US Micron
Sub-Investigator: Betty J. Tsuei, M.D.
“Doripenem vs Imipenem for Ventilator Associated Pneumonia”
June 22, 2005 – December 2007
Peninsula PPD
Sub-Investigator: Betty J. Tsuei, M.D.
“A multi-center, double blind, randomized, phase 3 study to compare the safety and efficacy of
intravenous Doripenem with that of Meropenem in complicated intra-abdominal infections”
April 14, 2005 – July 2006
Johnson and Johnson Carestat
Sub-Investigator: Betty J. Tsuei, M.D.
“A randomized, double blind, placebo-controlled study to determine the efficacy and safety of
Epoetin Alfa in critically ill patients”
April 14, 2005 – January 2008
Altana/Omnicare
Sub-Investigator: Betty J. Tsuei, M.D.
“Venticute (rSP-C Surfactant) in patients with pneumonia or aspiration of gastric contents leading
to intubation, mechanical ventilation, and severe oxygenation impairment (valid study)”
March 17, 2005 – January 2008
BCI
Sub-Investigator: Betty J. Tsuei, M.D.
“Phase 1 specimen procurement for Access Immunoassay Systems: Sepsis Assay”
March 9, 2005 - March 2007
Wyeth Covance
Sub-Investigator: Betty J. Tsuei, M.D.
“A phase 3 multi-center, randomized, double blind comparative study of the efficacy and safety
of Tigecycline vs Imipenem/Cilastatin for the treatment of patients with nosocomial pneumonia”
February 4, 2005 – December 2006
National Institute of Diabetes and Digestive and Kidney Diseases (NIH).
Sub-Investigator: Betty J. Tsuei, M.D.
“Placement of Nasoenteral Feeding Tubes Using External Magnetic Guidance.”
September 1, 2003 – August 31, 2005 - $15,007.00, UKRF#4-67265
Eli Lilly and Co.
Sub-Investigator: Betty J. Tsuei, M.D.
“Efficacy and Safety of Drotecogin Alfa (Activated) in Adult Patients with Early Stage Severe
Sepsis.”
August 1, 2003 – July 31, 2005 - $43,400.00, UKRF#4-67205
Wyeth Research.
Sub-Investigator: Betty J. Tsuei, M.D.
“A Multicenter, Double-Blind, Randomized, Comparison Study of the Efficacy and Safety of
Tigecycline to Imipenem/Cilastatin to Treat Intra-Abdominal Infections in Hospitalized Subjects.”
March 14, 2003 – March 2005 - $85,804.70 UKRF# 4-66698
GlaxoSmithKline
Sub-Investigator: Betty J. Tsuei, M.D.
“A Prospective Observational Study of Acute Major Organ System Failure in Septic Patients.
EMD20003.”
January 1, 2003 to January 2005 - $40,195.56 UKRF# 4-66610
Betty J. Tsuei, MD
Curriculum Vitae
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Eli Lilly and Company
Sub-Investigator: Betty J. Tsuei, M.D.
A Randomized, Open-Label, Multi-center, Clinical Trial, Comparing Microbiologic Response to
Linezolid and Vancomycin in Ventilator-Associated Pneumonia (VAP) Due to Methicillin
Resistant Staphylococcus aureus (MRSA).”
January 1, 2003 – January 2005 - $109,906.06 UKRF # 4-66550
Merck & Co., Inc.
Sub-Investigator: Betty J. Tsuei, M.D.
“A Prospective, Multicenter, Double-Blind, Randomized, Comparative Study to Evaluate the
Safety and Efficacy of Tolerability, and Efficacy of a Single Dose of Ertapenem sodium (MK0826) Versus Cefotetan for the Prophylaxis of Surgical Site Infection Following Elective
Colorectal Surgery.”
September 5, 2002 – September 2005 - UKRF# 4-66334
ICOS Corporation.
Sub-Investigator: Betty J. Tsuei, M.D.
“A Phase 3 Study to Demonstrate the Safety and Efficacy of Recombinant Platelet-Activating
Factor Acetylhydrolase (rPAF-AH, Pafase) for Reducing 28 Day All Cause Mortality in Patients
with Severe Sepsis”
August 31, 2001-April 2004, $110,925.89, UKRF# 4-65248
University of Kentucky Medical Center Research Grant.
Principal Investigator: Betty J. Tsuei, M.D.
“Evaluation of Arginase Activity after Trauma.”
July 2002-June 2003, $14,997, UKRF # 208540.
Eli Lilly and Company.
Sub-Investigator: Betty J. Tsuei, M.D.
“A Phase IIb Study to Determine the Efficacy and Safety of LY315920 in Patients with Severe
Sepsis.”
March 1, 2002 – March 2003 - $101,626.00 UKRF# 4-65571
Eli Lilly
Principal Investigator: Betty J. Tsuei, M.D.
“A Phase II Study to Determine the Efficacy and Safety of Sivelestat in Subjects with Acute Lung
Injury.”
October 21, 2001- $114,000.59 UKRF #465307
Eli Lilly and Company
Sub-Investigator: Betty J. Tsuei, M.D.
“An Open-Label Study of Recombinant Human Activated Protein C in Severe Sepsis-A Phase 3b
Clinical Trial.”
September 18, 2001-July 16, 2002, $23,941. UKRF# 464956
Eli Lilly and Company.
Sub-Investigator: Betty J. Tsuei, M.D.
“Long-Term Follow-Up Survivors from the Prowess Trial (An Observational Study).”
September 1, 2001 to September 1, 2002 - $4,914.00 UKRF #4-65445
Bristol Myers Squibb
Principal Investigator: Betty J. Tsuei, M.D.
“A Randomized, Double-Blind, Multi-Center, Comparative Phase III Study of Intravenous BMS284756 Followed by Oral BMS-284756 Versus Intravenous Piperacillin/Tazobactam Followed by
Oral Amoxicillin/Clavulante in the Treatment of Complicated Intraabdominal Infections.” March
1, 2001 to March 1, 2003 - $91,734.99 UKRF #464566
Betty J. Tsuei, MD
Curriculum Vitae
9
Wyeth-Ayerst Research
Sub-Investigator: Betty J. Tsuei, M.D.
“A Multicenter Open-Label Study of the Safety and Efficacy of GAR-936 to Treat Complicated
Intra-Abdominal Infections in Hospitalized Patients.”
September 1, 2000 to March 31, 2002 - $72,000. UKRF# 4-64125.
OrthoBiotech Inc.
Principal Investigator: Betty J. Tsuei, M.D.
“A Prospective, Multicenter Study of the Anemia of Critical Illness and Transfusion in the
Critically Ill Patient.”
July 20, 2000-November 15, 2001, $11,300. UKRF# 464485
Chiron
Sub-Investigator: Betty J. Tsuei, M.D.
"Multicenter, Double Blind, Placebo Controlled, Randomized, Phase 3 Study of tifacogin
[Recombinant Tissue Factor Pathway Inhibitor (r-TFPI/SC-59735)] in Severe Sepsis."
April 12, 2000-February 28, 2002, $150,011.56 UKRF #4-63757
Byk Gulden Pharmaceuticals/Atana Inc .
Sub-Investigator: Betty J. Tsuei, M.D.
“Venticute (rSP-C Surfactant) for the Treatment of Acute Respiratory Distress Syndrome
(ARDS). A Randomized, Multinational, Multicenter, Parallel Group, Double Blind, Controlled
Study.”
December 21, 1999-November 14, 2002. $114,642.01 UKRF # 463504
Eli Lilly
Sub-Investigator: Betty J. Tsuei, M.D.
“ A Phase III Study to Determine the Efficacy and Safety for Recombinant Human Activated
Protein C in Severe Sepsis.”
October 19, 1999-September 18, 2001, $90,830.00 UKRF #463496
Ortho-McNeil Pharmaceutical/Advanced Biologics
Sub-Investigator: Betty J. Tsuei, M.D.
“A Multicenter, Randomized, Open Label Study to Compare the Safety and Efficacy of
Levofloxacin with that of Imipenem/Cisplatin in the Treatment of Nosocomial Pneumonia.”
September 13, 1999-July 22, 2002, $132,137.41 UKRF # 463296
Alliance Pharmaceutical Corp
Principle Investigator: Betty J. Tsuei, M.D.
“Multicenter, Prospective, Randomized, Controlled Pivotal Trial for Efficacy of Partial Liquid
Ventilation (PLV) with Low and High doses of Perflubron in Adult Patients with Acute Lung
Injury.”
May 21, 1999-March 14, 2002, $117,903.24; UKRF #462998.
Northfield Laboratories
Sub-Investigator: Betty J. Tsuei, M.D.
“The Multi-Centered Evaluation of the Safety and Efficacy of Poly SFH-P [Polymerized Human
Hemoglobin (Pyridoxylated)] Injection in Acute Blood Loss. Study RTBSE – 4.”
April 26, 1999-March 13, 2001, $107,502.00; UKRF #463143.
ICOS Corporation
Sub-Investigator: Betty J. Tsuei, M.D.
“A Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Platelet Activating
Factor Acetylhydrolase (rPAF-AH) for the Prevention of Acute Respiratory Distress Syndrome
(ARDS) in Patients with Severe Sepsis or Severe Traumatic Injuries”.
March 2, 1999-May 1, 2000, $127,999.94; UKRF #462843
Betty J. Tsuei, MD
Curriculum Vitae
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Chiron Technologies
Sub-Investigator: Betty J. Tsuei, M.D.
“ Multicenter, Single-Blind, Placebo-Controlled, Randomized, Dose Escalation Study of
Recombinant Tissue Factor Pathway Inhibitor (rTFPI/SC-59735) in Severe Sepsis.”
January 15, 1999-January 19, 2000, $80,000; UKRF #462654.
Eli Lilly and Company
Sub-Investigator: Betty J. Tsuei, M.D.
“A Phase II Study to Determine the Efficacy and Safety of LY315920 in Patients with Severe
Sepsis.”
September 24, 1998-October 29, 1999, $75,912.48; UKRF #4-62404.
Knoll Pharmaceuticals
Sub-Investigator: Betty J. Tsuei, M.D.
Randomized Placebo-Controlled Trial of MAK195F in Sepsis with Hyperinflammatory Response
(MAK 195F 009)
November 29, 1995-October 29, 1999, $132,000; UKRF #4-29751
American Cancer Society Fellowship - Ohio Chapter
CCK and Gastrin Receptors in Pancreatic Carcinoma
July 1,1994 – June 30, 1995; $9,600
American Cancer Society Fellowship - Ohio Chapter
CCK and Gastrin Receptors in Pancreatic Carcinoma
July 1, 1993 – June 30, 1994; $9,600
INVITED LECTURESHIPS
1. Hypothermia in the trauma patient. University of Kentucky Tenth Annual Trauma Symposium,
October 28, 1999. Lexington, KY.
2. Liquid ventilation. University of Kentucky Department of Surgery Grand Rounds, May 13, 2000.
Lexington, KY.
3. Liquid ventilation. University of Kentucky Department of Pharmacy Critical Care Lecture, October 3,
2000. Lexington, KY.
4. Liquid Ventilation in the Treatment of ARDS. University of Kentucky Eleventh Annual Trauma
Symposium, November 9, 2000. Lexington, KY.
5. Management of the open peritoneal cavity. University of Kentucky Department of Surgery Grand
Rounds, April 4, 2001. Lexington, KY.
6. The sick post-operative patient. University of Kentucky Family Practice Review, November 15,
2002. Lexington, KY.
7. The pregnant trauma patient. University of Kentucky Thirteenth Annual Trauma Symposium,
November 7, 2002. Lexington, KY.
8. Management of the open peritoneal cavity. American College of Surgeons, Kentucky Chapter,
Spring meeting. April 12, 2002. Louisville, KY.
9. The sick post-operative patient. University of Kentucky Family Practice Review, February 21, 2003,
Lexingon, KY.
Betty J. Tsuei, MD
Curriculum Vitae
11
10. The sick post-operative patient. University of Kentucky Family Practice Review, May 23, 2003,
Lexingon, KY.
11. Sepsis. 2012 Midwest EMS Conference. Feb 18, 2012, Cincinnati, OH.
12. Point-Counterpoint XXXI. Extensive adhesiolysis: an indication for placement of a sterile,
bioresorbable adhesion barrier (CON). June 11, 2012, National Harbor, MD.
ABSTRACTS
1. Tsuei BJ, Povoski SP, Zhou W, and Bell RH. In vitro autoradiographic localization of increased
cholecystokinin binding to azaserine-treated rat pancreas. Gastroenterology 1994,106:A327.
2. Zhou W, Povoski SP, Tsuei BJ, and Bell RH. Gene expression of the cholecystokinin-A receptor
and the cholecystokinin-B (gastrin) receptor in human pancreatic carcinomas. Gastroenterology
1994,106:A331.
3. Boulanger BR, Kearney P, Ochoa J, Tsuei BJ, Gorczca J, and Park A. Minimally invasive fixation
of flail chest: When and to what endpoints? Crit Care Med 1999, 27(1) Suppl: A18.
4. Barksdale AR, Bernard AC, Tsuei BJ, Boulanger BR, Kearney PA, Ochoa JB. Synergy of
catecholamines with T-Helper II cytokines induces arginase in macrophages. Surg Forum 2001:156159.
5. Tsuei BJ, Bernard AC, Meier CF, Barnes SL, Boulanger BR, Kearney PA. Supplemental enteral
arginine is metabolized to ornithine in injured patients. J Surg Res. 2003 Oct;114(2):247.
6. Clifford TM, Magnuson BL, Swintosky ME, Hoskins LA, Tsuei BJ. Egg whites for protein
supplementation in critically ill patients. Pharmacotherapy 25(3): 467.
7. Tsuei BJ, Mueller E, Lisco S, Friedrich A, Henson K, Allard K, Goocey L, Goetz S, Johannigman J.
Effect of a patient focused analgesia-sedation protocol without daily interruption in a surgical
intensive care unit. Crit Care Med. 2006 Dec;34(12):A147.
8. Freeman CM, Callcut RA, Robinson BRH, Athota KA, Mueller EW, Branson RD, Tsuei BJ.
Incidence of delirium in geriatric surgical intensive care patients. J Am Coll Surg 2009, 209(3)
Suppl:S54-55.
9. Grewal SJ, Hanseman DJ, Tsuei BJ. Improved detection of delirium in the intensive care unit. Crit
Care Med 2010, 38(12) Suppl: A36.
MANUSCRIPTS
1. Donaldson VH, Wagner CJ, Tsuei BJ, Kindness G, Bing DH, Harrison RA, and Rosen FS,
“Interactions of plasma kallikrein and C1-s with normal and dysfunctional C1(-)-inhibitor proteins from
patients with hereditary angioneurotic edema: analytic gel studies.” Blood. 1987, 69:1096-1101.
2. Tsuei BJ, Povoski SP, Zhou W, and Bell RH. Cholecystokinin (CCK) receptors in early rat
pancreatic carcinoma. Int J Pancreatology. 1994, 16:291-294.
3. Tsuei BJ, Povoski SP, Zhou W, and Bell RH. Gastrin receptor expression during azaserine-induced
pancreatic carcinogenesis. J Surg Res. 1996, 63:105-109.
4. Tsuei BJ, Povoski SP, Zhou W, and Bell RH. Autoradiographic localization of cholecystokinin
(CCK) receptor during the development of azaserine-induced rat pancreatic carcinoma. Pancreas.
1996 Nov;13(4):401-406.
Betty J. Tsuei, MD
Curriculum Vitae
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5. Bernard AC, Griffen MM, Tsuei BJ, Boulanger BR, Kearney PA, Ochoa JB. Trauma increases
arginase activity in human peripheral blood leukocytes. Surgical Forum. 1999;Vol L:266-9.
6. Bernard AC, Fitzpatrick EA, Maley ME, Gellin GL, Tsuei BJ, Arden WA, Boulanger BR, Kearney PA,
Ochoa JB. Beta adrenoceptor regulation of macrophage arginase activity. Surgery. 2000
Apr;127(4):412-418.
7. Kearney PA, Griffen MM, Boulanger BR, Ochoa JB, Tsuei BJ, Mentzer RM. A single center eightyear experience with percutaneous dilational tracheostomy. Ann Surg. 2000;231(5):701-709.
8. Ochoa JB, Bernard AC, Mistry SK, Morris SM, Figert PL, Maley ME, Tsuei BJ, Boulanger BR,
Kearney PA. Trauma increases extrahepatic arginase activity. Surgery. 2000;127(4):419-426.
9. Boulanger B, Kearney P, Brenneman F, Tsuei BJ, Ochoa J: Utilzation of FAST (Focused
Assessment with Sonography for Trauma) in 1999: results of a survey of North American trauma
centers. Am Surg. 2000 Nov; 66(11):1049-1055.
10. Ochoa JB, Bernard AD, O’Brien WE, Griffen MM, Maley ME, Rockich AK, Tsuei BJ, Boulanger BR,
Kearney PA, Morris SM, Jr. Arginase I expression and activity in human mononuclear cells after
injury. AnnSurg. 2001;233(3):393-399.
11. Bernard AC, Mistry SK, Morris SM, Jr., O’Brien WE, Tsuei BJ, Maley ME, Shirley LA, Kearney PA,
Boulanger BR, Ochoa JB. Alterations in arginine metabolic enzymes in trauma. Shock.
2001;15(3):215-219.
12. Boulanger B, Kearney P, Tsuei BJ, Ochoa J, Sands F: Telemedicine: A solution to the outpatient
follow-up of rural trauma victims? J Am Coll Surg. 2001 Apr;192(4): 447-452.
13. Nicholas C, Zgoda M, Kearney P, Boulanger B, Ochoa J, Tsuei BJ: Simple bedside placement of
nasal-enteral feeding tubes: A case series. Nut Clin Prac. 2001;16(3):165-168.
14. Boulanger BR, Kearney PA, Tsuei BJ, Ochoa JB: The routine use of sonography in penetrating
torso injury is beneficial. J Trauma. 2001 Aug; 51(2): 320-325.
15. Tsuei BJ, Bernard AC, Shane MD, Shirley LA, Maley ME, Boulanger BR, Kearney PA, Ochoa JB.
Surgery induces human mononuclear cell arginase I expression. J Trauma. 2001 Sep;51(3):497502.
16. Griffen M, Boulanger BR, Kearney PA, Tsuei BJ, Ochoa J. Injury during contact with horses: recent
experiences with 75 patients at a level I trauma center. South Med J. 2002 Apr;54:441-445.
17. Tsuei BJ, Magnuson B, Swintosky M, Flynn J, Boulanger BR, Ochoa JB, Kearney PA. Tolerance
and Efficacy of Enteral Nutrition in Patients with Open Peritoneal Cavity. Nutr Clin Prac. 2003
June;18:253-258.
18. Bernard AC, Magnuson B, Tsuei BJ, Swintosky M, Marnes SL, Kearney PA. Defining and assessing
tolerance in enteral nutrition. Nutr Clin Pract. 2004;19(5):481-486.
19. Tsuei BJ, Liao J, Kearney PA. Treating posttraumatic delayed diaphragmatic hernia. Surg Rounds.
2003 Sept;427-432.
20. Tsuei BJ, Lyu P. Chest Radiography. Atlas Oral Maxillofac Surg Clin North Am. 2003
Sep;10(2):189-211.
Betty J. Tsuei, MD
Curriculum Vitae
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21. Tsuei BJ, Schwartz R. Current management of pancreatic pseudocysts. Current Surgery. 2003
Nov;60(6):587-590.
22. Tsuei BJ, Kearney PA. Hypothermia in the trauma patient. Injury. 2004;35:7-15.
23. Tsuei BJ, Schwartz R. Management of the difficult duodenum. Current Surgery. 2004;61(2):166171.
24. Barksdale AR, Bernard AC, Kearney PA, Gellen G, Maley M, Boulanger BR, Tsuei BJ, Ochoa JB.
Regulation of arginase expression by T-helper II cytokines and isoproterenol. Surgery.
2004;135(5):527-35.
25. Tsuei BJ, Skinner JC, Bernard AC, Boulanger BR, Kearney PA. The open peritoneal cavity:
etiology correlates with the likelihood of fascial closure. Am Surg. 70(7):652-656, 2004.
26. Tsuei BJ, Clifford TM, Magnuson BL, Kearney PA. The open abdomen: enteral access results in
cost savings. Hosp Pharm. 2005;40(3):240-246.
27. Tsuei BJ, Bernard AC, Barksdale AR, Meier CF, Rockich AK, Kearney PA. Supplemental enteral
arginine is metabolized to ornithine in injured patients. J Surg Res. 2005;123(1):17-24.
28. Tsuei BJ. Assessment of the pregnant trauma patient. Injury 2006;(37):367-373.
30. Bernard AC, Whitaker M, Ray M, Rockich A, Barton M, Barnes S, Boulanger B, Tsuei B, Kearney P.
Impact of language barrier on acute care medical professionals is dependent upon role. J Prof
Nurs. 2006; 22(6): 355-358.
31. Kelly S, Ray M, Tsuei BJ. Trends concerning a common interview question, revisited. Med Teach
2007; 29(5): e139-e142.
32. Brink VA, Mueller EW, Tsuei BJ, Henson K, Wolfe J, Ernst NE, Lisco SJ. A patient-focused protocol
for the evaluation and management of analgesia, sedation, and delirium in critical ill surgical
patients: preliminary results of the APPEASED study. Crit Care Med. 2007:35(12, suppl), A243.
33. Clarke CN, Tsuei BJ, Butler KL. Equine-related injury: a retrospective analysis of outcomes over a
10 year period. Am J Surg 2008: 195 (702-704)
34. Robinson BRH, Mueller EW, Kenson K, Branson RD, Barsoum S, Tsuei BJ. An analgesia-deliriumsedation protocol for critical ill trauma patients reduces ventilator days and hospital length of stay. J
Trauma. 2008 Sep; 65 (3): 517-526
35. Barnes SL, Robinson BRH, Richards JT, Pritts TA, Tsuei BJ, Butler KL, Muskat PC, Davis K, Jr.,
Johannigman JA. The devil is in the details: maximizing revenue for daily trauma care. Surgery.
2008 Oct;144(4):670-5; discussion 675-6.
36. Finlay-Morreale JE, Tsuei BJ, Fisher BS, Davis K, Johannigman JA. Close is dead: determinants of
firearm injury lethality in females. J Trauma. 2009;66(4):1207-1211.
37. Huber N, Giglia J, Starnes S, Tsuei B. Concomitant blunt aortic and thoracic duct injury. Injury
Extra. 2009;40(5);81-3.
38. Rangel EL, Butler KL, Johannigman JA, Tsuei BJ, Solomkin JS. Risk factors for relapse of
ventilator-associated pneumonia in trauma patients. J Trauma. 2009;67(1):91-5; discussion 95-6.
Betty J. Tsuei, MD
Curriculum Vitae
14
39. Burns JB, Branson R, Barnes SL, Tsuei BJ. Emergency Airway Placement by EMS providers:
comparison between the King LT supralaryngeal and entotracheal intubation. Prehsop Disaster Med
2010 Jan-Feb; 25(1):92-5.
40. Goodman MD, Pritts TA, Tsuei BJ. Development of a novel method of progressive temporary
abdominal closure. Surgery 2010. Oct;148(4):799-805.
41. Early treatment of blunt cerebrovascular injury with concomitant hemorrhagic neurologic injury is
safe and effective. Callcut RA, Hanseman DJ, Solan PD, Kadon KS, Ingalls NK, Fortuna GR, Tsuei
BJ, Robinson BR. J Trauma Acute Care Surg. 2012 Feb;72(2):338-45; discussion 345-6.
BOOK CHAPTERS
1. Tsuei BJ. Peptic ulcer disease. The Mont Reid Surgical Handbook, third edition. Koutlas TC, ed.
Mosby-Year Book, Inc., 1994.
2. Tsuei BJ. Gastrointestinal bleeding. The Mont Reid Surgical Handbook, third edition. Koutlas TC,
ed. Mosby-Year Book, Inc., 1994.
3. Tsuei BJ. Abscess drainage. The Mont Reid Surgical Handbook, third edition. Koutlas TC, ed.
Mosby-Year Book, Inc., 1994.
4. Tsuei BJ. Peptic ulcer disease. The Mont Reid Surgical Handbook, fourth edition. Berry SM, ed.
Mosby-Year Book, Inc., 1996.
5. Tsuei BJ. Gastrointestinal bleeding. The Mont Reid Surgical Handbook, fourth edition. Berry SM, ed.
Mosby-Year Book, Inc., 1996.
6. Tsuei BJ. Abscess drainage. The Mont Reid Surgical Handbook, fourth edition. Berry SM, ed.
Mosby-Year Book, Inc., 1996.
7. Tsuei BJ, Pritts T. Initial assessment and intensive care of the trauma patient. Textbook of Oral and
Maxillofacial Surgery, 2nd edition, R. Fonseca ed.
PRESENTATIONS
1. Tsuei BJ, Povoski SP, Zhou W, and Bell RH. In vitro autoradiographic localization of increased
th
cholecystokinin binding to azaserine-treated rat pancreas. Presented at the 28 Annual Pancreas
Club Meeting, New Orleans, Louisiana, May 15, 1994.
2. Tsuei BJ, Zhou W, and Bell RH. Loss of gastrin receptor is associated with a change in phenotype
of azaserine-induced rat pancreatic carcinoma. Presented at the 35th Annual Meeting of the Society
for Surgery of the Alimentary Tract, New Orleans, Louisiana, May 16, 1994.
3. Tsuei BJ, Povoski SP, Zhou W, and Bell RH. Temporal neoexpression of the gastrin receptor
during the development of azaserine-induced rat pancreatic carcinoma in vivo. Presented at the 25th
Annual Meeting of the American Pancreatic Association, Chicago, Illinois, November 2, 1994.
4. Zhou W, Povoski SP, Tsuei BJ, and Bell RH. Gene expression of the cholecystokin-A receptor and
th
the cholecystokinin-B (gastrin) receptor in human pancreatic carcinomas. Presented at the 25
Annual Meeting of the American Pancreatic Association, Chicago, Illinois, November 2, 1994.
Betty J. Tsuei, MD
Curriculum Vitae
15
5. Tsuei BJ, Povoski SP, Zhou W, and Bell RH. Gastrin receptor expression during the development
of azaserine-induced rat pancreatic carcinoma. Presented at the 29th Annual Meeting of the
Association for Academic Surgery, Dearborn, Michigan, November 11, 1995.
6. Boulanger BR, Kearney P, Ochoa J, Tsuei B, Gorczca J, and Park A. Minimally invasive fixation of
flail chest: When and to what endpoints? Presented at the Society of Critical Care Medicine
meeting, San Francisco, California, Jan 24, 1999.
7. Bernard AC, Maley ME, Fitzpatrick EA, Tsuei BJ, Ochoa JB. Macrophage arginase activity is
induced by catecholamines-an effect inhibited by propranolol. Presented at the Society of University
Surgeons meeting, Sixtieth Annual Meeting, Resident Forum, New Orleans, LA, February 11, 1999.
8. Bernard AC, Maley ME, Fitzpatrick EA, Tsuei BJ, Gellin GL, Arden WA, Boulanger BR, Kearney PA,
Ochoa JB. Trauma-induced arginase activity is mediated by endogenous catecholamines and
inhibited by beta antagonists. Presented at the American College of Surgeons, Kentucky Chapter,
Spring Meeting, May 1999.
9. Griffen MM, Boulanger BR, Ochoa, JB, Tsuei BJ, Kearney PA. Percutaneous tracheostomy: An
eight year experience. American College of Surgeons, Kentucky Chapter, May 7, 1999.
10. Bernard AC, Tsuei BJ, Shirley LA, Maley ME, Boulanger BR, Kearney PA, Ochoa JB. Trauma
induces immune cell iNOS expression but paradoxically decreases plasma nitric oxide metabolites-A
role for arginase regulation. Presented at the Kentucky Committee on Trauma, American College of
Surgeons, August 1999.
11. Bernard AC, Morris SM, Tsuei BJ, Boulanger BR, Kearney PA, Ochoa JB. Arginase I protein
expression is increased after trauma-potential modulation of nitric oxide production. Presented at
the American Association for the Surgery of Trauma meeting, Boston, Sept 17, 1999.
12. Boulanger B, Tsuei BJ, Ochoa J, Sands F, Withrow L, Sprang R: Outpatient follow-up of remote
trauma victims by telemedicine: We have the technology but should we take the next step.
Presented at American Association for the Surgery of Trauma meeting, Boston, Sept. 17, 1999.
13. Griffen M, Boulanger B, Kearney P, Tsuei BJ, Ochoa J. A review of 75 patients admitted with
horse-related injuries to a single trauma center. Abstract presented at the Trauma Association of
Canada meeting, Montreal, September 24, 1999.
14. Bernard AC, Griffen MM, Tsuei BJ, Boulanger BR, Kearney PA, Ochoa JB. Trauma increases
arginase activity in human peripheral blood leukocytes. Presented at the American College of
Surgeons meeting, San Francisco, Oct 13, 1999.
15. Bernard AC, Mistry SK, Morris SM, Tsuei BJ, Maley ME, Boulanger, BR, Kearney PA, Ochoa, JB.
Alterations in L-Arginine metabolizing enzymes in trauma. American College of Surgeons,
Committee on Trauma, Regional Paper Competition, Charlotte, North Carolina, November 20, 1999.
16. Kearney, PA, Griffen, MM, Ochoa, JB, Boulanger, BR, Tsuei BJ, Mentzer, RM. Percutaneous
dilational tracheostomy: Experience with 827 procedures. Presented at Southern Surgical
Association, Hot Springs, Virginia, December 5-8, 1999.
17. Nicholas CD, Zgoda, M., Boulanger BR, Ochoa, JB, Tsuei BJ, Kearney, PA. Simple bedside
placement of nasal-enteral feeding tubes: a prospective study. Presented at the American Society of
Parenteral and Enteral Nutrition, 24th Clinical Congress, Nashville, Tennessee, January 23-26, 2000.
Betty J. Tsuei, MD
Curriculum Vitae
16
18. Griffen M, Boulanger B, Kearney P, Tsuei BJ, Ochoa J. A review of 75 patients admitted with
horse-related injuries to a single trauma center. Presented at the Southeastern Surgical Congress
meeting, Lake Buena Vista, Florida, Feb 7, 2000.
19. Boulanger B, Tsuei BJ, Ochoa J, Sands F, Kearney P, Withrow L, Sprang R: Early Experience with
the outpatient follow-up of remote trauma victims by telemedicine. Abstract presented at the
Southeastern Surgical Congress meeting, Lake Buena Vista, Florida, Feb 7, 2000.
20. Bernard AC, Shane MD, Ochoa JB, Morris SM, Kearney PA, Boulanger BR, Tsuei BJ. Elective
surgery increases arginase activity and expression in human peripheral blood leukocytes and
decreases plasma nitric oxide metabolites. Presented at the Society of University Surgeons, Toronto,
Canada, February 10, 2000.
21. Bernard AC, Mistry, SK, Morris SM, Tsuei BJ, Maley ME, Boulanger, BR, Kearney PA, Ochoa, JB.
Alterations in L-Arginine metabolizing enzymes in trauma. American College of Surgeons,
Committee on Trauma, National Paper Competition, Reno, Nevada, March 8-10, 2000.
22. Bernard AC, Shane MD, Ochoa JB, Morris SM, Kearney PA, Boulanger BR, Tsuei BJ. Elective
surgery increases arginase activity and expression in human peripheral blood leukocytes and
decreases plasma nitric oxide metabolites. Presented at the Kentucky Chapter of the American
College of Surgeons, Spring Meeting, Lexington, Kentucky, March 24, 2000.
23. Nicholas CD, Zgoda, M, Boulanger BR, Ochoa, JB, Tsuei BJ, Kearney PA. Simple bedside
placement of nasal-enteral feeding tubes: A prospective study. Presented at the Kentucky Chapter
of the American College of Surgeons, Spring Meeting, Lexington, Kentucky, March 24, 2000.
24. Boulanger BR, Kearney PA, Tsuei BJ, Ochoa JB, Bernard AC, Griffen MM. The Routine Utilization
of Sonography in Penentrating Torso Injury is Beneficial. Presented at the 60th Annual Meeting or the
American Association for the Surgery of Trauma, San Antonio, Texas, October 12-14, 2000.
25. Davis J, Magnuson B, Swintosky M, Ochoa J, Tsuei B. Assessment of cost-savings analysis of
enteral administration of medications and nutrition in patients with an open peritoneal cavity.
Presented at the annual KYSPEN meeting, Lexington, Kentucky, July 2001.
26. Barksdale AR, Bernard AC, Tsuei BJ, Boulanger, BR, Kearney PA, Ochoa JB. Synergy of T-helper
cytokines and TGF-B with isoproterenol induces arginase in marcrophages. American College of
Surgeons, Surgical Forum, New Orleans, Louisiana, October 9, 2001.
27. Plymale MA, Tsuei BJ, Donnelly MB. The effects of organizational factors on student learning in
surgery clerkship. American Association of Medical Colleges Annual Meeting, November 2-7, 2001,
Washington, D.C.
28. Bernard AC, Barnes SL, Kearney PA, Tsuei BJ, Loveless PS, Boulanger BR. Adolescent Trauma
Vehicle. Presented at Kentucky Chapter, American College of Surgeons, Committee on Trauma,
Louisville, Kentucky October 18, 2002.
29. Bernard AC, Matthews M, Endean ED, Kearney PA, Boulanger BR, Tsuei BJ, Loveless PS, Barnes
SL. Pediatric amputations in trauma. Presented at Kentucky Chapter, American College of
Surgeons, Committee on Trauma, Louisville, Kentucky October 18, 2002.
30. Bernard AC, Barnes SL, Kearney PA, Tsuei BJ, Loveless PS, Boulanger BR. Adolescent Trauma
Vehicle. Presented at the American College of Surgeons, Committee on Trauma Regional Paper
Competition, Chattanooga, Tennessee November 16, 2002.
Betty J. Tsuei, MD
Curriculum Vitae
17
31. Tsuei BJ, Bernard AC, Meier CF, Barnes SL, Boulanger BR, Kearney PA. Supplemental enteral
arginine is metabolized to ornithine in injured patients. Presented at the 37th Annual Meeting of the
Association of Academic Surgeons, Sacramento, California, November 14, 2003.
32. Clifford TM, Magnuson BL, Swintosky ME, Hoskins LA, Tsuei BJ. Egg whites for protein
supplementation in critically ill patients. Presented at the Spring Practice and Research Forum of
the ACCP, Myrtle Beach, South Carolina, April 2005.
33. Branson RD, Lyons E, Johannigman JA, Davis K, Tsuei BJ. Comparison of three new generation
pulse oximeters during routine ICU monitoring of ventilated patients. Presented at the annual
meeting of the American Association for Respiratory Care, Las Vegas, NV, December 2006.
®
34. Henson KM, Tsuei BJ. Using Project IMPACT data to develop and evaluate a sedation protocol in
the SICU. Presented at the 2nd annual Cerner Critical Care Forum, Orlando, FL, February 2007.
35. Tsuei BJ, Mueller E, Lisco S, Friedrich A, Henson K, Allard K, Goocey L, Goetz S, Johannigman J.
Effect of a patient focused analgesia-sedation protocol without daily interruption in a surgical
intensive care unit. Presented at the 36th Critical Care Congress of the Society of Critical Care
Medicine, Orlando, FL, February 2007.
36. Henson KM, Tsuei BJ. The development and evaluation of a patient-focused sedation protocol in a
surgical/trauma intensive care unit (SICU). Presented at the 2nd annual Anthem Regional Hospital
Quality Improvement Forum, Columbus, OH, March 2007.
37. Lu EJ, Butler KL, Tsuei BJ, Johannigman JA, Solomkin JS. Factors associated with ventilatorassociated pneumonia recurrence in the surgical intensive care unit. Presented at the 27th Annual
Meeting of the Surgical Infection Society, Toronto, Canada, April 2007.
38. Clarke CN, Tsuei BJ, Butler KL. Equine-related injury: a retrospective analysis of outcomes over a
10 year period. Presented at the annual meeting of Society of Black Academic Surgeons, Cincinnati,
OH, April 2007.
39. Lu EJ, Butler KL, Tsuei BJ, Johannigman JA, Solomkin JS. Factors associated with ventilatorassociated pneumonia recurrence in the surgical intensive care unit. Presented at the Surgical
Infection Society Symposium, Toronto 2007.
40. Lu EJ, Butler KL, Tsuei BJ, Johannigman JA, Solomkin JS. Factors associated with ventilatorassociated pneumonia recurrence in the surgical intensive care unit. Presented at the 66th Annual
Meeting of the American Association for the Surgery of Trauma, Las Vegas, NV, September 2007.
41. Robinson BRH, Mueller EW, Henson K, Tsuei BJ. Effect of an analgesia-sedation-delirium protocol
st
with daily interruption in critically ill trauma patients. Presented at the 21 Proceedings of the Eastern
Association for the Surgery of Trauma, Amelia Island, FL, January 2008.
42. Brink VA, Mueller EW, Tsuei BJ, Henson K, Wolfe J, Ernst NE, Lisco SJ. A patient-focused protocol
for the evaluation and management of analgesia, sedation and delirium in critically ill surgical
th
patients: preliminary results of the APPEASED study. Presented at the 37 Annual Meeting, Society
of Critical Care Medicine, Honolulu, HI, January 2008.
43. Finlay-Morreale, HE, Tsuei BJ, Fisher BS, Johannigman JA. Close is dead: the relationship between
assailant and victim is the primary determinant of firearm injury lethality in women. Presented at the
Annual Proceedings, Western Trauma Association, Squaw Valley, CA, February 2008.
Betty J. Tsuei, MD
Curriculum Vitae
18
44. Barnes SL, Richards T, Pritts TA, Robinson BR, Tsuei BJ, Butler KL, Muskat PC, Davis K, Jr.,
Johannigman JA. Devil is in the details: maximizing revenue for daily trauma care. Presented at the
65th Annual Meeting, Central Surgical Association, Cincinnati, OH, March 2008.
45. Freeman CM, Callcut RA, Robinson BRH, Athota KA, Mueller EW, Branson RD, Tsuei BJ.
th
Incidence of delirium in geriatric surgical intensive care patients. Presented at the 94 Annual
Clinical Congress, American College of Surgery. Chicago, IL, October 2009.
46. Goodman MD, Pritts TA, Tsuei BJ. Development of a novel method of progressive temporary
abdominal closure. Presented at the 67th Annual Meeting, Central Surgical Association, Chicago, IL,
March 2010.
47. Grewal SJ, Hanseman DJ, Tsuei BJ. Improved detection of delirium in the intensive care unit.
Presented at the 40th Annual Meeting, Society of Critical Care Medicine, San Diego, CA, January
2011.
48. Callcut, RA, Hanseman DJ, Solan PD, Kadon KS, Ingalls MK, Fortuna GR, Johannigman JA, Tsuei
BJ, Robinson BRH. Early treatment of blunt cerebrovascular injury with concomitant hemorrhagic
neurologic injury is safe and effective. Presented at the 70th Annual Meeting, American Association
for the Surgery of Trauma, Chicago, IL, September, 2011.