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Medullary Thyroid Carcinoma
From diagnosis to treatment
Hans Verbeek
Medullary Thyroid Carcinoma
From diagnosis to treatment
Verbeek, H.H.G.
Cover:
Wouter van de Gronde, www.woutr.nl
Printed by:
Ipskamp Drukkers
ISBN:
978-90-367-7392-8 (print)
978-90-367-7391-1 (eBook)
Copyright
© 2014 H.H.G. Verbeek, The Netherlands
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval
system, or transmitted in any form or by any means, without prior written
permission of the author.
Financial support for printing of this thesis was kindly provided by: The Endocrinology Fund, as part
of the Ubbo Emmius Fund, University Medical Center Groningen and University of Groningen.
Medullary Thyroid Carcinoma
From diagnosis to treatment
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 7 januari 2015 om 16.15 uur
door
Hans Hendrik Gijsbert Verbeek
geboren op 1 september 1985
te Emmen
Promotores
Prof. dr. T.P. Links
Prof. dr. J.T.M. Plukker
Prof. dr. R.M.W. Hofstra
Beoordelingscommissie
Prof. dr. W.J.G. Oyen
Prof. dr. I.H.M. Borel Rinkes
Prof. dr. E.G.E. de Vries
Contents
Chapter 1
General introduction and aims of the thesis
Chapter 2
Medullary thyroid cancer, a tumour with many appearances
17
Chapter 3
Calcitonin testing for detection of medullary thyroid cancer
27
7
in patients with thyroid nodules
Chapter 4
Fewer cancer reoperations for medullary thyroid cancer
57
after initial surgery according to ATA guidelines
Chapter 5
PET imaging in thyroid carcinoma
73
Chapter 6
Clinical relevance of 18F-FDG PET and 18F-DOPA PET in
91
recurrent medullary thyroid carcinoma
Chapter 7 The effects of four different tyrosine kinase inhibitors on
109
medullary and papillary thyroid cancer cells
Chapter 8
Summary, discussion and future perspectives
125
Nederlandse samenvatting
139
Dankwoord
147
Curriculum vitae
151
Appendices
153
Paranimfen:
B. Kok
C.H. Verbeek