RESEARCH DISCUSSIONS / 2014-15 BIOM/PHAR 295 DEPARTMENT OF PHARMACOLOGY LEICHTAG 107, FRIDAYS TIME SLOT A -- 9:00 - 9:30 AM TIME SLOT B -- 9:30 - 10:00 AM (20 min. presentation, 10 min. question/answer period) For other AV needs, contact the Pharmacology Education Office at least one week prior to your presentation Refreshments served at 8:45 AM ABSOLUTELY NO CHANGES WITHOUT PHARMACOLOGY EDUCATION OFFICE APPROVAL 3-Oct A Dorrestein Vanessa Phelan Characterizing the Chemotypic Landscape of Cystic Fibrosis Sputum 3-Oct B Guan Jenna Jewell Differential Regulation of mTOR by Amino Acids 10-Oct A Dixon Vinnie Tagliarbracci Phosphorylation of secreted proteins by a new family of kinases 10-Oct B Evans Nuno Camboa HIF1α represses ATF4 and preempts p53 pathways to promote proliferation of fetal cardiomyocytes 17-Oct A Insel Anna Busija Cardiac myocyte-specific overexpression of caveolin-3 enhances response to β-adrenergic stimulation 17-Oct B Gustafsson Babette Hammerling Identification of a Novel Pathway of Parkin-Mediated Mitochondrial Clearance in Cardiac Myocytes 24-Oct A Tsien Varda Levram-Ellisman Very long-term memories may be stored in the pattern of holes in the perineuronal net 24-Oct B Trejo Buxin Chen N-linked glycosylation of protease-activated receptor-1 regulates signal pathway bias 31-Oct A Joiner Jim Robinson Regulation of the sleep/wake cycle in Drosophila by Adar and its effectors 31-Oct B Karin Amy Strasner PPARg as a potential mediator of ADSC-derived mammary CAF 7-Nov A Newton Maya Kunkel Paradoxical increase in Protein Kinase D phosphorylation upon inhibitor binding 7-Nov B Guan Toshiro Moroishi A YAP/TAZ-Induced Feedback Mechanism Regulates Hippo Pathway Homeostasis 14-Nov A Heller Brown Stephanie Dusaban PLCε mediates heterotrimeric and small GTPase signaling in CNS injury and disease 14-Nov B McCammon Yinglong Miao Structure-based Design of Allosteric Modulators of a Muscarinic G-protein Coupled Receptor 21-Nov A Tsien Csilla Felsen Exploiting Protease Activity to Image and Study Inflammatory States 21-Nov B Yang Laurent Fattet Role of Twist1 in cellular mechanosensing 28-Nov Thanksgiving Holiday 5-Dec A Heller Brown Charlie Gray The role of CaMKIIdelta splice variants in ischemia/reperfusion injury 5-Dec B Insel Aaron Overland GPCRs and Heterotrimeric G proteins directly regulate Membrane Type-1 Matrix Metalloprotease 12-Dec A Joiner Meilin Wu Regulation of ion channels and ionotropic receptors by Ly6 proteins 12-Dec B Guan Henry Park The Role of YAP/TAZ as Mediators of Alternative Wnt Signaling 19-Dec A Tukey Shujuan Chen Nuclear receptor co-repressor NCoR1 and developmental expression of intestinal xenobiotic processing genes 19-Dec B Adams Malik Keshwani Proline-Directed Phosphorylation regulates SR Protein Function and Splicing 12/26/2014 - 1/2/2015 Holidays 9-Jan A S. Taylor Hiruy Meharena Synchronized Intra-Molecular Interactions Regulating EPK Function 9-Jan B Trejo Neil Grimsey Differential regulation of GPCR endosomal sorting by Rab11A and Rab11B 16-Jan A Karin Juyoun Kim New ways to combat NASH: Defining the role of TNFR1 in de novo lipid synthesis through caspase2-mediated SREBP1 processing 16-Jan B Radic/P. Taylor Zoran Radic Allosteric modulation of butyrylcholinesterase oxime reactivation, in vitro and in vivo 23-Jan A Tsien Stephen Adams Multi-color electron microscopy 23-Jan B Newton Ksenya Cohen-Katsenelson PHLPP phosphatase as a modifier of histone code 30-Jan A Heller Brown Alessandra Castaldi Role of GPCRs in Cardiac Progenitor Cells 30-Jan B Karin Tse Yuan (Jerry) Wong Chronic NF-κB activation sensitizes intestinal epithelial cells to tumour necrosis factor-induced programmed cell death 6-Feb A Dixon Xing Guo Phospho-regulation of the 26S proteasome 6-Feb B P. Taylor Kasia Kaczanowski Novel nAChRs Modulators for Treating CNS Disorders: Discovery of AChBP Cooperative Ligands 13-Feb A S. Taylor Ronit Ilouz Specificity and distinct spatial localization of PKA regulatory subunits in the brain 13-Feb B Karin Zhenyu Zhong The role of p62 in innate immunity 20-Feb A Tsien Alex Kislukhin Fluorinated materials for non-invasive cell tracking in vivo 20-Feb B Newton Corina Antal Protein Kinase C Loss-of-Function Mutations in Cancer Reveal Role as Tumor Suppressor 27-Feb A Karin Debanjan Dhar Signaling Pathways that Lead to Hepatocellular Carcinoma 27-Feb B Dennis Varnavas Mouchlis Hydrogen/Deuterium Exchange Mass Spectrometry and Molecular Dynamics Reveal the Interactions of Membrane Phospholipids and Inhibitors with Phospholipases A2 6-Mar A Insel Shu Zhou GPCRs as potential therapeutic targets in pancreatic cancer-associated fibroblasts 6-Mar B Trejo Michael Dores GPCR signaling initiates ALIX ubiquitination to regulate GPCR lysosomal sorting 13-Mar A Gustafsson Amabel Orogo Accumulation of mtDNA Mutations Impairs Mitochondrial Function in Cardiac Progenitor Cells and in the Heart 13-Mar B Joiner Rou-Jia Sung Novel Modulation of Glutamate receptor activity by a family of prototoxin-like molecules 20-Mar A S. Taylor Ping Zhang PKA macromolecular signaling complex 20-Mar B Yang Haeyun Jung The plasticity of Twist1-mediated EMT regulates tumor dormancy March 27 Cesar Chavez Holiday 3-Apr A Hook Bailey Miller Marine natural products in the neurosciences: screening and isolation of cysteine cathepsin inhibitors 3-Apr B Daneman Roeben Munji Neurochemical balance and the blood-brain barrier 10-Apr A Karin Koji Taniguchi The Role of gp130 Signaling in Intestinal Homeostasis and Tumorigenesis 10-Apr B McCammon Steffen Lindert Molecular Dynamics and Calcium Binding Studies on Cardiac and Skeletal Troponin 17-Apr A Tsien Mike Whitney Targeted probes for monitoring disease and image guided surgery 17-Apr B Daneman Fabien Sohet LSR, a tricellular tight junction protein involved in Blood-Brain Barrier formation 24-Apr A Trejo Patrick Menzies Activated Protein C Promotes Co-Association of Protease-Activated Receptor 1 and Sphingosine-1-Phosphate Receptor 1 at the Plasma Membrane 24-Apr B McCammon Alisha Caliman Allosteric Modulators of the Sphingosine-1-Phosphate Receptor Subtype 1 1-May A Yang Trenis Palmer Novel mediators of invadopodia mediated degradation 1-May B Reya Jeevisha Bajaj Adhesive signaling in leukemia growth and progression 8-May A S. Taylor Kris Haushalter ROS-dependent modulation of PKA signaling in cardiac ischemia/reperfusion injury 8-May B Joiner Clare Puddifoot Modulation of nicotinic acetylcholine receptors by endogenous prototoxins 15-May A Handel To be decided Structure of the complex of chemokine receptor CXCR4 with the viral chemokine, vMIP-II 15-May B Reya Ray Fox Inhibition of Musashi Disables Progression of Pancreatic Adenocarcinoma 22-May A Chang Steve Rees Perpetual Toxicity: The Dysregulation of P-gp by Environmental Pollutants 22-May B Jain Jain Metabolism and Metabolomics of Human Disease 29-May A Heller Brown Olivia Yu The role of GPCRs in transcriptional coactivator responses 29-May B Chun Nicole Stoddard The role of lysophosphatidic acid signaling in initiating premature infantile post-hemorrhagic hydrocephalus 29-May C Leffert Leffert Liver stem cells and growth control 5-Jun A Heller Brown Andrew Willeford Defining the Activity and Role of CaMKIId During B-Adrenergic Stimulation 5-Jun B Lipton Olga Prikhodko S-Nitrosylation of CRTC1 Regulates CREB Activity in Neurodegenerative Disorders 5-Jun C Gustafsson Sarah Shires Role of the E3 Ubiquitin Ligase Parkin in protein and organelle quality control 12-Jun A Yang Hannah Majeski The role of Tyk2 in regulating Twist1 in response to matrix stiffness 12-Jun B Joiner Lawrence K. Satterfield Investigation of the molecular mechanisms and neural circuitry underlying sleep homeostasis using Drosophila melanogaster as a model system 12-Jun C Newton Agnes Grzechnik The Role of PHLPP in the Regulation of the Histone Code