Debut Issue, Fall/Winter 2014 The Magazine of the Multiple Myeloma Research Foundation Multiple myeloma at a transformational moment Making precision medicine a reality for multiple myeloma patients we are curing cancer accelerator The Magazine of the Multiple Myeloma Research Foundation | Fall/Winter 2014 Features Our pipeline is the strongest in our history. Researchers who used to compete now collaborate. 5 THE ACCELERATORS Technology companies are How the MMRF reached this transformational moment. stepping up. Sequencing 6 KNOW EVERYTHING THAT IS HAPPENING IN MYELOMA 12 COVER STORY The MMRF CoMMpass Study seeks to make precision Introducing the redesign of themmrf.org. SM medicine a reality. individual genomes is providing exciting roadmaps to a cure. Life expectancy has nearly tripled. And we have launched our NOW WE ARE PROUD TO SHOW YOU WHAT THE MMRF HAS ACHIEVED IN 2014. Drug Development People Events 7 14 DONOR PROFILES 18 MMRF ANNUAL FALL GALA 16 MMRF LEADERSHIP 20 MMRF CHICAGO CLINICAL TRIAL NEWS 10 MULTIPLE MYELOMA AWARDS DINNER MASTER PROTOCOL 11 MMRF RESEARCH AWARDS MMRF in the News 26 MMRF MEDIA HIGHLIGHTS fundraising campaign, 21MMRF LAUGH FOR LIFE: NEW YORK 22 MMRF TEAM FOR CURES 25 INDEPENDENT EVENTS the largest in our history. 27CALENDAR To learn more, or to make ABOUT THE COVER a donation, please visit themmrf.org. The promise of personalized medicine. The more we learn about cancers affecting different parts of the body, the more biologically similar we find them to be. See what we are learning in the groundbreaking MMRF CoMMpass StudySM on page 12. SPONSORS We thank our sponsors for their support of Accelerator, The Magazine of the Multiple Myeloma Research Foundation 3 The Accelerators How the MMRF reached this transformational moment A letter from Walter M. Capone Dear friend of the MMRF, The mission to cure multiple myeloma has entered a critical, transformative time. Working with strong partners in industry and academia, the MMRF is leading new, bold initiatives and advancing promising therapies to bring overwhelming force in the fight against myeloma. So far this year, we’ve brought 3 new classes of drugs into our clinical study portfolio (p. 8) and are launching one of the first targeted therapy trials in myeloma. The MMRF CoMMpassSM Study, cornerstone of our precision medicine initiative, is on track to complete enrollment by year end. We have identified thousands of mutations and are seeing patients respond well to the six treatment approaches that predominate in first line treatment. Learn more about our progress (p. 12). Our fundraising efforts have received a strong boost from two new funds (p. 14), and we are in the process of launching the NOW campaign, the largest capital campaign in MMRF history. The NOW campaign is the first of several changes that we have made at the MMRF, which include a user-friendlier website (p. 6) and our redesigned magazine. Driven by their own experiences with Part 2: The MMRF CoMMpassSM Study centers. This is the idea behind the MMRF cancer, and/or a personal mission, the “Open science” is a central tenet of Researcher Gateway, which centralizes men and women who lead the MMRF are the MMRF’s strategy to accelerate and shares genomic data to accelerate united in their goal to disrupt the status a cure. So all data from the MMRF discovery of individualized treatment quo and accelerate the path to a cure. CoMMpass Study is being placed on the approaches, biomarkers, diagnostics and MMRF Researcher Gateway, a public new drug targets. The result of the team’s work, which includes leadership roles in Clinical portal, to accelerate data sharing and hypothesis generation for new clinical As we move into 2015, we are designing new academic, industry Research, Clinical Operations, and government researcher partnerships, and are developing new Translational Research, and Strategic networks, research tools, and international clinical trial consortia. Partnerships, has four key components: I can see the future. We are closing in on it faster than ever — Part 1: The Multiple Myeloma years with sequential tissue sampling it is a world without cancer. Genomics Initiative to identify how a molecular profile may The MMRF was the first to sequence affect response to treatment. On behalf of all of us at the MMRF, we thank you for your support the myeloma genome and put the and wish you and your loved ones a happy New Year! results in a centralized repository Sincerely, for researchers to share through the Initiative’s Genomics Portal. The result is the largest data set ever published in myeloma. Walter M. Capone trials. CoMMpass is tracking 1,000 patients from initial diagnosis through their course of treatment for at least 8 T HE MMRF.ORG Finding a cure depends on everyone in the myeloma community — researchers, industry, clinicians, and patients. That is why the MMRF established the MMRF CoMMunity Gateway, to empower patients to become active participants in their own care by sharing their Part 3: The MMRF journey in our search for better, more Researcher Gateway targeted treatments. Keenly aware of the bottlenecks typical in cancer research, the MMRF leadership team aims to engage all possible stakeholders, including researchers, drug companies, and academic/community President and Chief Executive Officer, MMRF Part 4: The MMRF CoMMunity Gateway Anne Quinn Young, M.P.H., Vice President, Development and Strategic Partnerships; Kathy Giusti, Founder and Executive Chairman MMRF and MMRC; and Walter M. Capone, President and Chief Executive Officer. 5 Know everything that is happening in myeloma Drug Development MMRC pipeline offers promise to patients It has been an exciting year for clinical trials. Our comprehensive new website is organized with you in mind. The most important element in the to add content in the months to come, who specialize in their particular area of Ed Johnson, a patient whose multiple quest to cure multiple myeloma is so visit themmrf.org today — and check genomics, and sign up for clinical trials that myeloma has relapsed, was researching might be right for them. treatments that have become available information. Circulating it quickly among the people who need it is key to the success of the MMRF, and critically important to the researchers, clinicians, pharmaceutical and biotechnology back often. Clinical Trial Finder Find a host of useful tools, starting Take action! Play a more active role in with these three: your healthcare, gain access to promising Free e-Newsletter pressing for a cure. Sign up for our monthly newsletter The new MMRF website is the conveyor of everything that is known and being and get updates about new treatments, new trials, and more. discovered in multiple myeloma. It is easy MMRF CoMMunity Gateway to use and organized to help you find out Participate in our search for better, about a treatment or clinical trial, a new more targeted treatments online. As incredibly exciting new since his diagnosis seven years ago. Discover these patient resources companies, and patients who are “We have opened six “Here’s another one,” he remembers trials for multiple myeloma saying. “Here’s another one. And patients who are running here’s another one. There are a lot new research treatments before they of options,” he continues. “A few years out of treatment options. are widely available, and help advance ago it was option A and ‘we’ll have to medical research to bring us closer to We are confident that hope that works.’” they will prove to have Call: 1-866-603-6628 Now, we are poised to make even greater progress toward a cure. This a significant impact for Email: [email protected] finding a cure. many of our patients.” year, the Multiple Myeloma Research Professional Education Consortium (MMRC) opened six new Gain access to significant clinical data clinical trials. These represent some published at major medical congresses of the most promising treatments in ASH, ASCO, EHA, and IMW. Learn from development today. “Together with our key opinion leaders in multiple myeloma committed and world-class partners, we who will highlight key clinical data. have opened six incredibly exciting new field of multiple myeloma research. It Visit the MMRF website to view trials for multiple myeloma patients who is designed to update you on promising CME-accredited webcasts. are running out of treatment options. Our mission is to keep that pipeline new developments and discoveries as There is such a robust pipeline of filled for Ed Johnson and other patients they occur. In this spirit, we will continue promising therapies — from monoclonal like him. development in our understanding of the more patients’ genomes are sequenced disease, and useful resources that can and mutations are discovered, the hope make a difference in your life. is that patients can connect with other The website is dynamic, just like the patients, then engage with researchers antibodies to first-in-class novel 6 T HE MMRF.ORG D RUG D E V E LOPME NT therapies, to all-oral regimens. We are confident that they will prove to have a significant impact for many of our patients,” said Fiona An, M.D., Senior —F iona An, M.D., Senior Vice President of Clinical Research for the MMRF and MMRC Vice President of Clinical Research for the MMRF and MMRC. The Johnson Family: Ed, Annie, Augie and Louis. 7 Hope for patients with relapsed myeloma These breakthrough MMRC clinical trials provide hope for relapsed patients who may have few options and whose cancer has not responded to previous treatments. The strength of the consortium The Multiple Myeloma Research Consortium (MMRC) is the first collaborative research model of its kind that brings together academic The MMRC, working with our industry Ibrutinib (Novel mechanism) monoclonal antibody. The MMRC is also Kyprolis. A mechanistically distinct way and community cancer centers with and academic research partners, This multicenter, Phase I/IIb trial is studying this investigational treatment of inhibiting this critical proteasome industry to advance innovative phase identified a strategy to drive drug studying ibrutinib in combination with in combination with Revlimid and pathway may provide benefit for patients 1 and phase 2 clinical trials of today’s discovery and development for patients Kyprolis® in patients with relapsed dexamethasone. The lead MMRC who are relapsed and refractory. The most promising drug candidates. University and Chairman of the with multiple myeloma at a rapid or relapsed and refractory multiple investigator is Tom Martin, M.D. of the lead MMRC sites are Emory University, The MMRC leads a robust clinical MMRC Steering Committee and the pace — studying the most promising myeloma. Oral ibrutinib blocks a University of California, San Francisco. overseen by Sagar Lonial, M.D., and the network of 21 Member Institutions Project Review Committee, praised therapeutics and most diverse science protein called Bruton’s tyrosine kinase. University of California, San Francisco, across the country that work together the MMRC for its diligent work this on parallel paths. Because of the It is currently approved by the U.S. overseen by Jeffrey Wolf, M.D. as one. MMRC Member Institutions year and the new lifesaving drugs it complex nature of the disease, we are Food and Drug Administration (FDA) are supported by an advanced is developing in collaboration with prioritizing three core approaches — for the treatment of Chronic infrastructure, including a cutting- industry partners. “The ability of our immunotherapies and antibodies, Lymphocytic Leukemia. The lead edge Tissue Bank and IT systems that myeloma-focused clinicians to rapidly novel drug mechanisms, and targeted MMRC investigator is Ajai Chari, M.D. enable rapid, seamless collaboration. move laboratory data into real-world therapies — to identify therapeutics of Mount Sinai Hospital. ® Ixazomib (MLN9708) (Novel agent) ® themmrc.org This Phase I/II trial is studying ixazomib Additional Clinical Trials (MLN9708) in combination with The MMRF and the MMRC have Pomalyst and dexamethasone for accelerated more than 50 clinical trials relapsed or relapsed and refractory and are currently supporting many trials multiple myeloma. Ixazomib is the first oral at various stages of development. For Sagar Lonial, M.D., Vice Chairman consortium. New treatments and Selinexor (KPT-330) proteasome inhibitor in development. If more information about the MMRF’s of Clinical Affairs Department of combinations represent the future (Novel mechanism) approved by the FDA, it could provide an current research work and research Hematology and Medical Oncology, of how we will treat myeloma. The Following is information on our six This Phase I study is evaluating easier and more convenient route of drug services we can provide, please Winship Cancer Institute, Emory strides made just this year will help new trials which are currently open for the Selective Inhibitor of Nuclear administration for many patients than contact Daniel Auclair, Vice President our patients in their goals to control enrollment: Export (SINE) selinexor (KPT-330) current treatments in this class, which are of Translational Research at and ultimately cure the disease,” in combination with Kyprolis and administered by IV infusion or injection. [email protected]. Dr. Lonial said. dexamethasone in patients with The lead MMRC site is the City of Hope relapsed or relapsed and refractory National Medical Center, overseen by multiple myeloma. Selinexor is the first Amrita Krishnan, M.D. with the most promise and deliver them to patients in a meaningful timeframe. ® Marizomib (NPI-0052) (Novel agent) This Phase I, multicenter, open-label, dose-escalation study is evaluating the combination of marizomib, Pomalyst® and low-dose dexamethasone (PMD) in patients with relapsed or refractory multiple myeloma. Marizomib is a novel proteasome inhibitor in the same class as Velcade® and Kyprolis.® MMRC has also studied this drug in Phase I as a single agent. Investigators believe that it can work in patients who are resistant drug in the SINE class to be studied in multiple myeloma. MMRF played a key role in advancing the study of selinexor in multiple myeloma through the grant of a Biotech Investment Award in 2010 to the drug’s developer, Karyopharm. The lead MMRC investigator is Andrej Jakubowiak, M.D., Ph.D. at the University of Chicago. ® CB-5083 (Novel mechanism) This Phase I, open-label, dose-escalation first-in-man study of CB-5083, the first p97 inhibitor to enter clinical trials. Several MMRC member institutions worked closely with manufacturer Cleave Biosciences on the preclinical work, which suggested activity in Immunotherapies and Antibodies Targeted Therapies lead MMRC investigator is Paul This is a Phase I study of SAR650984 degradation and the proteasome Richardson, M.D. at the Dana-Farber as a single agent for the treatment pathway, and inhibits this pathway at Cancer Institute. of relapsed or refractory multiple a different intervention point than the myeloma. SAR650984 is an anti-CD38 proteasome inhibitors, Velcade and Approved Novel Agents Mechanisms Doxil ® AT7519 Ixazomib ABT-199 Ibrutinib Kyprolis SAR650984 GSK21110183 Marizomib ARRY520 Panobinostat Pomalyst Siltuxumab MLN128 Oprozomib CB-5083 Selinexor Revlimid OSI906 Ganetespib ® ® ® Thalomid Velcade ® ® New Diagnostic Approaches Janssen Diagnostics, LLC, CELLSEARCH® n Circulating Tumor Cell (CTC) Test ® T HE MMRF.ORG We have prioritized three core approaches to identify treatment options — immunotherapies and antibodies, targeted therapies, and novel mechanisms. Elotuzumab TKI258 novel protein that is involved in protein 8 The MMRF and the MMRC are supporting a pipeline that pursues the most promising therapeutics to help extend and save the lives of people living with multiple myeloma. PD0332991 SAR650984 (Antibody) n Robust Clinical Pipeline for Multiple Myeloma multiple myeloma. CB-5083 targets a to other proteasome inhibitors. The clinical trials is a real strength of the D RUG D E V E LOPME NT Sequenta n LymphoSIGHT™ 9 The MMRF goes to Washington A meeting with key regulatory agencies, industry, academia and patients yields encouraging results. On October 22nd, the MMRF hosted a “Myeloma is an incredibly complex, The Multiple Myeloma Master Protocol workshop in Washington, D.C. to discuss heterogeneous disease. There is would enable several Phase II clinical and advance the development of a an acute need for new therapies, trials to take place at the same time but Multiple Myeloma Master Protocol — particularly for patients whose cancer within a single study design. Patients a novel clinical trial design that would has relapsed,” said Shaji Kumar, M.D., enrolled in the trial would be assigned allow multiple new therapies targeting Mayo Clinic College of Medicine. to an appropriate treatment arm based specific mutations to be evaluated “The evidence suggests that this is on a genetic analysis of their cancer. simultaneously, completing in a single the right approach to accelerate the Decisions to advance a drug to Phase III trial what would normally require five development of targeted treatments. testing in a specific genetic subgroup, or or more individual studies. This may When finalized, this Master Protocol to test a different drug in this subgroup, cut years off traditional approaches, will be a major landmark for the could be more quickly expedited — with delivering potential breakthrough multiple myeloma community.” the goal of getting new drugs to patients MMRF Senior Research Awards MMRF Research Fellow Award faster than ever before. MMRF Senior Research Awards fund MMRF Research Fellow Award cutting-edge basic science and pre- supports innovative research conducted While real progress has been made in clinical research focused on accelerating by talented young investigators working $1,375,000 in Senior the battle against multiple myeloma, the development of novel treatments. under the supervision of a senior Research and Research therapies to patients faster than ever before. More than 80 participants from the U.S. Food and Drug Administration, the National Cancer Institute, the pharmaceutical, biotech and diagnostic industries, academic centers, and the patient community attended the workshop and endorsed a plan to move forward with the development of this novel study protocol. MMRF Research Awards fund important discoveries there is still more work to do to bring new, effective, personalized treatments Qing Yi to patients. The MMRF is committed to The Cleveland Clinic Foundation moving the project forward as quickly as possible. Kari Hemminki German Cancer Research Center, Heidelberg, Germany research mentor. Kim Chan Chung University Health Network, Toronto Ontario, Canada Jens Lohr In 2014, the MMRF funded Fellow Awards. The MMRF acknowledges generous contributions from Amgen, Bristol-Myers Squibb, Dana-Farber Cancer Institute Genentech, Millennium, University of California — John Simmons Onyx, Celgene, and Novartis San Francisco (UCSF) National Cancer Institute in support of the awards. Stephen Nutt Eric Smith The Walter and Eliza Hall Institute Memorial Sloan-Kettering of Medical Research, Australia Cancer Center David Toczyski Mike Chapman The University of Cambridge, United Kingdom D RUG D E V E LOPME NT 11 Data Update We anticipated: Making precision medicine a reality for multiple myeloma patients A wide spectrum of different myeloma n subtypes at initial diagnosis A variety of treatment approaches n A small proportion of patients with n complex mutation patterns We are seeing: Over 10,000 mutations, or mutation n combinations; myeloma is a heterogeneous type of cancer Six treatment approaches predominate n in first-line treatment for myeloma patients, with bortezomiblenalidomide-dexamethasone prevailing as the most commonly used therapeutic regimen (~60% of cases) Patients are responding well — n medications are holding a majority of patients’ disease in check for at least Individual biology Progress report Understanding the genomic The MMRF CoMMpass study is making underpinnings of individual patients enormous progress thanks to all the genomic) from interim analyses is the goal of the MMRF CoMMpassSM inspiring patients and researchers who 1–4 are included in the MMRF patterns not previously discovered, or Study. This groundbreaking study, the have joined it. Highlights of the study Researcher Gateway which can if discovered, not previously confirmed, cornerstone of the MMRF precision include the following: be accessed by researchers around until now medicine initiative, is designed to profile 1,000 newly diagnosed patients by obtaining their clinical and genomic 1,211 patients have been screened enrolled* least 8 years — and then linking this data to patients’ clinical responses. By revealing the biological basis of myeloma in this manner, and the disease’s response to treatments, it will accelerate new and even more effective therapies for patients, and perhaps the beginning of cures for many subtypes. 8 4 research sites are enrolling n Data and material sharing are placed on a public portal (the MMRF collaborations will be initiated in Researcher Gateway). The resulting data December 2014 allowing CoMMpass set will be the largest, most comprehensive to “piggyback” on other trials catalog of multiple myeloma including the patients in the U.S., Canada and Spain largest set of whole genome sequences. It will provide far more information than C oMMpass data is reviewed and n analyzed every six months; the 6th is possible from many current cancer Interim Analysis has been completed, tissue banks that typically include one which includes clinical data for 626 sample per patient. n patients, and 363 patients with full genomic profiling results It is yet another way we are curing cancer. *As of November 1, 2014 12 Some unique mutations and mutational n The findings of the CoMMpass StudySM n 743/1,000 active patients are information at an unprecedented level of detail — from initial diagnosis for at the world n n three years, and counting CoMMpass data (clinical and n T HE MMRF.ORG The Elseys Announce a $1 Million Matching Campaign The Linda Rodgers Emory Fund Precious Cat founders Dr. Bruce and Kathy Elsey donation establishes a fund to accelerate a cure. $1 million gift establishes a fund for accelerating immunotherapy in multiple myeloma. A new initiative from committed decided to make a transformative A strong partnership Linda Rodgers Emory, a longtime spreading to other parts of the body, and creative supporters commitment to the MMRF and began The Elseys have funded nearly supporter of the MMRF and multiple helping the immune system increase The Elseys, longtime supporters of donating a portion of purchases of $7 million to help discover and myeloma patient, has made a generous its effectiveness at eliminating cancer the MMRF, will match contributions their Precious Cat Litter products advance numerous new drugs into donation of $1 million. This funding will cells. Tremendous strides are being of the MMRF community by 100% to the MMRF. MMRC clinical trials, and to fuel the help expedite a pipeline of immuno- made in other cancers using these Precision Medicine Program featuring therapeutic agents to benefit myeloma types of approaches, including trials the CoMMpass Study,SM the MMRF patients, and enable critical research presented at the Annual American Researcher Gateway and the MMRF into the basic biology and mechanisms Society of Clinical Oncology (ASCO) CoMMunity Gateway. 2014 marked of immune response in myeloma. Meeting. This funding will be used to other compounds made by the body rapidly advance trials into the clinic. or developed in the laboratory, we are up to $1 million before the end of 2014. The gift establishes Dr. Elsey’s Fund to Cure Cancer. #CatsAgainstCancer In addition to the current challenge, “Our family has cancer,” he says. “We the Elseys have feel blessed that our family can support partnered on Kathy Giusti’s much larger family that a campaign to “Kathy and Bruce’s visionary leadership build and support the best portfolio of “Linda Rodgers Emory has provided also has multiple myeloma. Kathy Giusti’s raise awareness and inspirational support of the immunotherapeutic agents possible,” profound philanthropic leadership the fourth year of this collaboration. “I made this gift to the MMRF to help The power of immunotherapy Immunotherapy leverages the power of the best disease-fighting machine ever created — the human immune system — to identify, target, and overcome threats to our body. By using proteins and discovering new ways to activate, train and strengthen the immune system to recognize and shut down cancerous cells. family is the MMRF and they are and funds for myeloma research. The MMRF’s scientific and patient programs said Ms. Emory. “I am confident that to advancing myeloma research and working tirelessly to quickly find a cure.” campaign, #CatsAgainstCancer, spans have enabled advances that would the MMRF will assemble the best drug development over the years, to increase its effectiveness, patients Facebook, Twitter and Instagram using otherwise not be possible,” said Walter scientists and researchers from around for which we are extremely grateful,” may be able to avoid more toxic and the Photala photo sharing platform to M. Capone, Chief Executive Officer and the world to focus on this exciting area Kathy Giusti said. “This contribution debilitating therapies. The MMRF enable users to share their individual President of the MMRF. “In addition, of cancer research and work diligently will help us build the most robust is building a robust pipeline of experiences and support the campaign’s they have inspired further support to speed clinical trials of promising pipeline of immunotherapeutic agents immunotherapeutic approaches from mission. As part of the campaign, through generous contributions new approaches to benefit all multiple for myeloma, and will allow us to build novel antibodies to modified immune- When Kathy Elsey users can download a coupon from the from thousands of other donors. The myeloma patients.” collaborations with experts in system cells to vaccine-based therapies was diagnosed with campaign landing page that allows them establishment of Dr. Elsey’s Fund to immune biology in myeloma and that precisely target myeloma. multiple myeloma to save $3 on their next purchase of Cure Cancer will allow us to drive closer in 2009, she and a 40-pound bag of Precious Cat Ultra than ever towards a cure.” A transformative commitment This new initiative from the Elseys is not the first time they’ve provided generous support to the MMRF. Dr. Bruce Elsey wanted to do everything Litter. For every $3 saved, Precious Cat they could to attain a cure. Already will donate $3 to MMRF. generous philanthropists, the Elseys 14 Although it is not entirely clear how immunotherapy treats cancer, it is By permitting the immune system in other cancers.” thought to stop or slow the growth of cancer cells, or stop cancer from Kathy and Dr. Bruce Elsey with their grandchildren. T HE MMRF.ORG Linda Rodgers Emory, philanthropist, MMRF supporter, and multiple myeloma patient. PE OPL E 15 Leadership News Behind the Titles The MMRF welcomes three new cancer fighters Fiona An, M.D., Senior Vice President of Clinical Research Fiona is a global clinical research Daniel Auclair, Ph.D., Vice President of Translational Research Get to know the MMRF team members. Sharon Saias, Senior Director of Marketing Alicia O’Neill, Director of Endurance Events, walks the walk — and runs the races. Sharon’s marketing career spans more When Alicia O’Neill founded the MMRF Marathons, and development professional with Daniel, who managed than 25 years, with both client and Endurance Events program in 2007, triathlons, and significant experience in oncology and the MMRF Multiple agency experience in consumer and her first project was the New York City other endurance hematological malignancies in both Myeloma Genomics B-to-B marketing across a wide range Marathon. Twenty MMRF Team for events often academia and the pharmaceutical Initiative from of industries. Prior to joining MMRF, Cures members raised $125,000 and sell out fast, and industry. She recently joined the MMRF 2007-2010, rejoined Sharon served as Director of Marketing “we were on our way,” she says. In 2008, athletes who want from Pfizer, Inc., where she worked as the company in 2013 after three years at at Frontier Communications, Senior 63 runners ran eight world-class races, to compete gain a Senior Director of Global Oncology the Broad Institute of MIT and Harvard. Brand Manager with Kraft Foods, and including the Boston and Chicago entry by joining Digital Marketing Manager at illycaffè. marathons. “That first ‘real year’ of an official charity As senior leader in the Cancer She previously ran her own consulting a full program, we raised $325,000.” team. When they Program at the Broad Institute, Daniel business where she served both agency Clinical Development. Fiona began with molecular biology was involved with a wide range of and corporate clients, and included such and preclinical academic and industry collaborations companies as Communications Plus, oncology research at the Chinese Center centered around cancer genomics and personalized medicine. AMBI/CardiaNutrition, IBM, Lucent Technologies, and Reader’s Digest. for Disease Control and Prevention, the University of Chicago, and the Scripps Prior to this, he spent a decade in the Sharon began her career at Ogilvy & Research Institute, then expanded into pharmaceutical industry, most Mather where she managed such high- oncology clinical research and drug notably at Bayer Healthcare where he profile accounts as AMEX, AT&T and development at Pfizer. led a number of cancer drug discovery Vanguard Financial efforts. Prior to Pfizer, Fiona worked in Services. Sharon received her B.B.A. This year, MMRF Endurance Events raised more than $3 million with over 1,000 participants in 20 events. Success become part of Team for Cures, they agree to Alicia O’Neill participates in the Berlin Marathon. fundraise at a certain level and “they get involved. 2015 will also introduce learn about us,” says Alicia. “Over time, the Fifth Avenue Mile, one of the crown they become our champions.” In the jewels of the New York Road Runners, last IRONMAN event, they raised more and will, of course, continue to offer “I love the relationships, the ideas, than $8,000 per person. “They become the traditional 5K Walk/Runs in which building new programs into franchises,” connected to us, and excelled.” supporters of all ages participate. Alicia says. Perhaps most inspiring is MMRF Endurance Events have grown the kind of outcome she experienced “We want to mix things up and give from that first New York City Marathon in the first MMRF association with an our supporters lots of different ways to include U.S. and international IRONMAN® triathlon. “70 percent of to participate, and keep it fun and marathons, cycling events, triathlons, the people on the team had never heard interesting,” she says. and more. The MMRF is the Official of the MMRF when they signed up,” she Charity Partner of 2015 IRONMAN Alicia keeps things interesting for comes, in part, from the enthusiasm, creativity, and energy of Alicia and her staff, Jane Hoffmann and Kelley Ward. Business Development and New Daniel holds graduate and post- Products Marketing at Forest graduate degrees in Biochemistry Laboratories, Inc., as well as product and Nutrition from the University of management in Global Strategic Montreal and conducted postdoctoral Marketing at Janssen (Johnson & studies at the Dana-Farber Cancer explains, “and we wound up raising more herself, too. “I have done an event for Johnson) for Velcade. Institute/Harvard Cancer Center. Lake Placid and next year will add the money with that event than any event Spartan Race™ in Citi Field and Fenway the MMRF team every year: NYC in Marketing from Hofstra University. ever.” More important, “we created Park as well as a couple of Ragnar® Marathon, Boston, London, Marine Fiona has an M.D. from Beijing Medical incredible ambassadors who will Relay races. In addition, there are plans Corps Marathon, and most recently, University, an M.S. from the University continue to support us in other events.” for a 10-mile kayak event across Long Berlin. I think it’s important to “walk the Island Sound. But, Alicia emphasizes, walk” (or run the run!). Almost always, you don’t have to be a super athlete to I am the top fundraiser on the team.” of Chicago (concentration in Cancer Biology), and an M.B.A. from Stern School of Business at New York University. 16 T HE MMRF.ORG PE OPL E 17 The MMRF Fall Gala Is a Glittering Success 1 2 3 The premier fundraising event of the MMRF brought in more than $2,600,000 that will significantly help to fuel the research that will cure multiple myeloma. 1 1. New Orleans jazz filled the air. 2. Left to right: Paula and Warren 2 3 Berliner, Lori and Joe Dobrin The event, Fairfield County, 3. W. Dana LaForge and 4 5 Special Correspondent for NBC News of the MMRF. “The money we and multiple myeloma patient, was raise is critical to developing the awarded the MMRF Spirit of Hope next generation of genomic and Award, and William N. Hait, M.D., immunotherapeutic treatments as we Ph.D., received the MMRF Corporate move closer to discovering the cure for Chair Award. Dr. Hait is Global Head of myeloma. We greatly appreciate the Research and Development at Janssen enthusiasm, support and generosity Research Development, LLC. of all who participated.” Connecticut’s largest fundraiser, World-class entertainment was 4. Elizabeth and Traver Hutchins was attended by more than 1,100 provided by Wynton Marsalis, the 5. Left to Right: Linda Miller, Karen people, including many celebrities internationally acclaimed musician, Siebert, Hoda Kotb, Karen Andrews, and the nation’s most prominent composer, bandleader, educator, and Anna Povinelli, Julie Church business executives and high-impact Managing and Artistic Director of philanthropists. Jazz at Lincoln Center. Brian Williams, Anchor and Managing “Hosting this event is extremely 3. Wynton Marsalis Editor of NBC Nightly News, served as gratifying,” says Walter M. Capone, 4. David Letterman Master of Ceremonies. Tom Brokaw, Chief Executive Officer and President 5. Brian Williams Kathleen McCabe E V E NT S 4 5 1. Left to right: William N. Hait, M.D., Ph.D., Brian Williams, Tom Brokaw, Kathy Giusti, Wynton Marsalis, Walter M. Capone 2. Skip Brevis Band 19 Laugh for Life Raises $700,000 1 3 Chicago Awards Dinner Raises $800,000 2 1 4 2 3 5 6 5 6 4 April was an encouraging month for the faster and one day the MMRF will find a at CBS 2 Chicago and a multiple Fran Drescher was the honoree at MMRF. That is when more than 400 cure. I am honored to be recognized by myeloma patient, and Lester Knight, the 12th Annual Multiple Myeloma business, healthcare and community the MMRF, an innovative organization Founding Partner and Co-Chairman Research Foundation Laugh for Life: leaders attended the 12th Annual that helps so many cancer patients.” of RoundTable Healthcare Partners. New York evening held in May. Susie more to shape the future Connie L. Lindsey, Executive Vice “We are truly grateful for the remark- Essman, stand-up comedian, actress, of cancer research.” President and Global Head of able support shown tonight by our Corporate Social Responsibility speakers Bonnie Hunt, Mike Ditka and and Global Diversity & Inclusion at Connie Lindsey,” said Walter M. Capone, Northern Trust, Chicago, served as MMRF Chief Executive Officer and the event’s Patient Family Speaker. President. “Together we are playing Multiple Myeloma Research Foundation Chicago Awards Dinner to honor legendary NFL player, head coach and broadcaster Mike Ditka. The event raised more than $800,000, which will help extend patients’ lives and accelerate new treatments leading to a cure for multiple myeloma. Mr. Ditka was presented with the MMRF Courage and Commitment Award by the 2012 MMRF Spirit of Hope Award Honoree, Pat Williams, Senior Vice President of the NBA’s Orlando Magic. “By funding valuable cancer research and breaking down barriers in cancer research,” Mr. Ditka said, “countless patients will be able to get treatments 20 “I am here this evening with a heart filled with gratitude and a sense of urgency,” said Ms. Lindsey. “I am grateful for a vital role in the development of new and improved treatments for cancer patients.” artist, served as headliner for the at Fox Rothschild LLP and a member of the MMRF Board of Directors, was the evening’s Master of Ceremonies. They were joined by more than 625 tri-state area business, healthcare and community leaders who raised indefatigable pursuit of excellence research conducted by the MMRF. options for myeloma patients.” The event was also attended by notable Chicago guests including Derrick Blakley, General Assignment Reporter 1. Pat Williams, Walter M. Capone, Connie Lindsey, Kathy Giusti, Bonnie Hunt, Mike Ditka “The MMRF Laugh for Life event achieve that cause, and staying with it until the goal is achieved,” said Joel Beetsch, Vice President of Global Patient Advocacy at Celgene Corporation. “Celgene is proud to partner with the —F ran Drescher comedy event. Michael Reinert, Partner $700,000 to benefit the innovative transformed the approach to treatment “No organization is doing writer, television producer, and voice the MMRF and to Kathy Giusti whose and collaborative scientific research common cause, developing a plan to MMRF on behalf of the many, many patients and families it serves.” courage of patients, their families and friends,” said Walter M. Capone, Chief Executive Officer and President of the MMRF. “Thanks to those who inspire and support events like ‘Laugh,’ we are able to accelerate new and even more effective therapies for patients and advance cutting-edge research through our partnerships with the best 1. Elizabeth Hutchins provides us the opportunity to honor scientists, researchers and clinicians in 2. Walter M. Capone, Fran Drescher, Michael Reinert, Aviva Drescher, Anne Quinn Young 2. Mike Ditka all who are united in our mission to institutions and companies worldwide.” 3. Susie Essman 3. The Rosengarden Family with Mike Ditka cure myeloma, but especially the 4. Pat Williams “The MMRF is known for bringing great 4. Fran Drescher, Sherri Lippman, Sue Korn, Cindi Stern 5. Ryan Anthony researchers, scientists and the multiple 5. Skip Brevis Band 6. Connie Lindsey myeloma community together for a 6. Aviva Drescher, Michael Reinert T HE MMRF.ORG E V E NT S 21 Chicago Honorary Race Co-chairs: Team for Cures 5K Walk/Run Dr. Andrej Jakubowiak and Dr. Todd Zimmerman, Team for Cures 5K has raised more than $2 million with nearly 10,000 participants so far in 2014! The series is held annually in seven cities and participation offers camaraderie and knowledge sharing for patients, patient family members and friends, members of the myeloma community, and others. San Francisco The University of Chicago Medicine Attendees: .......................................... 1,791 Spirit of Hope Honoree: family donate to the MMRF rather Funds Raised: ............................. $539,340 Eli Coustan than give him presents for his seventh Top Team: 410 for Jill.................$78,225 Eli got involved with the MMRF so birthday in August. Whenever anyone Top Individual: that he could help raise awareness and asks why he is fundraising, he always Hal Anderson ................................$17,390 funds to cure multiple myeloma to save gives the same simple response, “I want his uncle Brad. Eli also decided that he to help save Uncle Brad.” Eli raised would prefer to have his friends and $14,363 for the MMRF. Boston Spirit of Hope Honorees: Allan Osborne Twin Cities Tri-State (CT, NJ, NY) When Allan and his wife Deb realized Honorary Race Co-chairs: Honorary Race Co-chairs: MMRF Courage and Commitment that the drugs responsible for Allan’s Dr. Shaji Kumar, Mayo Clinic Kathy Giusti Award Recipient: Mark Herzlich, and Walter M. Capone, MMRF New York Giants linebacker and remission were due to the work of Honorary Race Co-chairs: Honorary Race Co-chairs: the MMRF, they wanted to help the Dr. Paul Richardson, Dana-Farber research move forward. The Osbornes Cancer Institute and Dr. Michael and their friends have participated in Vasconcelles, Millennium, Takeda every event since 2010. Oncology Company Dr. Tom Martin and Dr. Jeffrey Wolf, Attendees: .......................................... 1,829 University of California San Francisco Funds Raised: ............................. $360,576 Attendees: .............................................. 750 Funds Raised: ............................. $225,633 Top Team: Team Susie...............$26,196 Top Individual: Jack Aiello .....$45,606 Spirit of Hope Honorees: Attendees: .......................................... 1,134 Funds Raised: ............................. $170,336 Attendees: .......................................... 1,263 Top Team: TEAM TIR(ED) .......$20,793 Funds Raised: ............................. $343,400 Top Individual: Top Team: Ericka Johnson .................................$1,980 Team Better Days..................... $108, 830 Top Individual: Gary Heinze ...$11,418 Top Team: Team Multiple Miracles..............$22,075 Top Individual: Paul Carter ....$18,560 Spirit of Giving Award: Maureen Willard Hurley Nation................................$11,747 Susie Castillo-Robson and Robert Robson bone cancer survivor After his diagnosis in 2009, Herzlich was told he would never play football again, and that his Spirit of Hope Honorees: survival odds were Megan Parker 10 percent. Two Megan started fundraising for the years later, he was MMRF to support her mother and a member of the continues to fundraise after her death. Super Bowl XLVI Spirit of Hope Honorees: On long runs, she would break down Championship Giants team. Herzlich Team Jeffy C & TNT in tears thinking about her. “There is shared his inspirational story and signed This courageous and growing team, nothing more motivating than stopping hundreds of copies of his new book, which has become very active in the someone else from feeing that pain. We What it Takes: Fighting for My Life and multiple myeloma community, works must find a cure.” My Love of the Game at the race. After Susie was diagnosed with multiple in support of all cancer patients, and myeloma, she said, “I wanted my years specifically in honor of Jeff Carlson and to matter. We decided the MMRF 5K Nate Tatarek. The MMRF 5K is a time for Walk/Run fit the bill for truly making an Jeff and Nate’s families to come together impact because the MMRF spearheads and remember Jeff who, sadly, passed such important and urgent work.” away in 2012 at the young age of 34, and honor Nate (coincidentally a friend and co-worker of Jeff’s) who continues to fight this disease daily. 22 T HE MMRF.ORG E V E NT S 23 Endurance events Independent events Amazing families put their passion to work and hosted more than 90 events that raised close to $1 million for the MMRF in 2014. Crawfish for Cancer Second Annual #bradstrong Golfs Against Cancer to Benefit the MMRF Eric Gelber (center) 200 Miles Towards a Cure 200 Miles Towards a Cure IRONMAN Lake Placid 2,185.3 miles on the Appalachian Trail Super-supporter and ultra-runner 110 athletes raised $865,000 in Mark St. John took time between jobs Eric Gelber, who has raised more than the prestigious IRONMAN Lake to hike the entire Appalachian Trail, $470,000 since 2008 via various ultra- Placid triathlon in July. The MMRF a five-month journey that resulted in marathon events, raised the bar even is the exclusive charity partner of over $10,000 raised for the MMRF. higher this year by attempting to run IRONMAN Lake Placid, one of the Mark made his epic journey to honor his The tournament that had the biggest 200 miles, in New York City’s Central most popular IRONMAN races. friend Paula Guerin, who lost her battle growth this year was hosted by Brad Park, Friday, Sept. 19 to Sunday 21. With Triathletes completed the 2.4-mile with multiple myeloma in 2011. Coustan, who was diagnosed with the support of Celgene Corporation, swim, 112-mile bike ride and 26.2-mile who recruited 33 employees to serve as marathon to cross the finish line and “lap captains,” Eric ran for an amazing 56 hear those magic words, “You are an New in 2015: hours, raising over $215,000. Hundreds IRONMAN.” And six MMRF athletes n of runners joined him during the course earned a spot in the IRONMAN and Fenway Park. VIP experience for of the two-plus days, including scores of World Championships in Kona, HI, the individuals and corporate teams. multiple myeloma patients who walked ultimate goal for triathletes. Visit our or ran with him to show gratitude website to see how the IRONMAN and support. Eric’s effort was part of running experiences are on the bucket program is expanding in 2015. list for many runners. ® the MMRF Your Own Race program, Ragnar Relays — 12-person, 200-mile for the MMRF. In 2014, over 20 golf tournaments were hosted across the country, raising more than $400,000 for critical myeloma research. Young philanthropists at a Crawfish for Cancer event multiple myeloma in 2012. Crawfish for Cancer (CFC Inc.) was CFC has grown from one event held The #bradstrong Golfs Against Cancer founded by James Crowell, whose each May in New York City to six events Golf Outing to Benefit the MMRF is held father, Lieutenant Colonel Lorenzo across the country in Atlanta, Boston, in Scotts Plains, New Jersey with over Mayo Crowell, USAF, Retired, passed Chicago, D.C., New York City and San 140 golfers and about 200 participants. away as a result of multiple myeloma Francisco. Hundreds of pounds of The event doubled its revenue this year, in March 2014. Louisiana crawfish are served along with raising over $51,000 for the MMRF. Fellow Williams College alumni and Kayak for a Cause — 100 kayakers will cross Long Island Sound.. adventure or race of their choosing. 24 n n where athletes can take on an athletic Challenging endurance events raised over $3 million in 2014. Spartan Stadium obstacle races in Citi Field Golf is a popular way to fundraise Learn more and get involved: themmrf.org/TeamForCures Glenn Pagan, IRONMAN® World Championships, Kona, HI. cofounders Peter Vecchio, Michael live music throughout the day. Graham and Scott Johnson helped The MMRF has received more than James launch CFC in 2008. Their idea $150,000 over the past five years and was to provide events that cater to $80,000 for CFC’s 2014 events. The young professionals and engage a 2015 Crawfish events promise to be new generation of philanthropists. even bigger with a season kick-off event The goal was to raise awareness and in Charleston, SC on April 11, 2015. funds for multiple myeloma research. T HE MMRF.ORG beer, wine and signature cocktails, with E V E NT S Brad Coustan and family. 25 accelerator MMRF in the news The MMRF has a compelling story to tell And the world wants to hear it. MMRF Signature Events The Magazine of the Multiple Myeloma Research Foundation | Fall/Winter 2014 Multiple Myeloma Research Foundation Spring 2015 MMRF Chicago Awards Dinner Chicago, IL 383 Main Avenue, 5th Floor, Norwalk, CT 06851 May 5, 2015 MMRF Laugh for Life: New York New York, NY Phone: 203-229-0464 Fax 203-229-0572 Fortune Magazine October 24, 2015 MMRF Annual Fall Gala Greenwich, CT The MMRF Online: The March issue of Fortune Magazine named Kathy Giusti number 19 of MMRF Endurance Events “The World’s 50 Greatest Leaders,” putting her in the company of the Pope March 15, 2015 New York City Half Marathon Register Online and the Dalai Llama. March 22, 2015 Quintiles Marathon and Half Marathon Register Online April 20, 2015 Boston Marathon Register Online Harvard Business School Club of New York In May, the largest alumni chapter of the Harvard Business School (HBS) awarded the John C. Whitehead Social Enterprise Award to Kathy Giusti in recognition of her profound commitment to social enterprise. April 26, 2015 Virgin London Marathon Register Online April 26, 2015 Big Sur International Marathon Register Online May 3, 2015 TD Five Boro Bike Tour Register Online May 9, 2015 Santa Barbara Wine Country Half Marathon Register Online May 9, 2015 Spartan Citi Field Sprint (Stadium) Coming Soon June 7, 2015 Escape from Alcatraz Register Online June 27, 2015 Kayak for a Cause Coming Soon Email: [email protected] Web: themmrf.org Board of Directors Kathy Giusti, Executive Chairman, Founder Kenneth Anderson, M.D. Karen E. Andrews William K. Bowes, Jr. Walter M. Capone Stephen Grand Eugene P. Grisanti David L. Lucchino W. Dana LaForge Joel S. Marcus Lori Tauber Marcus Gerald McDougall William S. McKiernan Chris A. McWilton Mike Mortimer Charles B. Ortner David R. Parkinson, M.D. Marie Pinizzotto, M.D. Michael Reinert Meryl Zausner Executive Committee Walter M. Capone President and Chief Executive Officer July 19, 2015 New York City Triathlon Register Online More Magazine July 26, 2015 IRONMAN Lake Placid Register Online The July issue of More Magazine featured Kathy Giusti in an article entitled, “One August 16, 2015 IRONMAN® Mont Tremblant Register Online of These Women Might Save Your Life.” The article cited Kathy for “speeding up the September 29, 2015 BMW Berlin Marathon Register Online pace of cancer research” and provided a crystal clear explanation of how the MMRF September 2015 Ragnar Relay D.C. Coming Soon has achieved so much in such a short time. September 2015 Fifth Avenue Mile Coming Soon October 10, 2015 IRONMAN® World Championship Kona Register Online October 11, 2015 Bank of America Chicago Marathon Register Online Sharon Saias Senior Director, Marketing FasterCures’ Innovator Spotlight November 1, 2015 TCS New York City Marathon Coming Soon In July, FasterCures, a Center of the Milken Institute, interviewed Walter M. Capone November 2015 Spartan Fenway Park Sprint (Stadium) Coming Soon Laura Gilman Director, Corporate and Independent Events as one of the “people driving some of the most promising consortia in medical MMRF 5K Walks/Runs research.” Walter’s interview is part a series that comprises FasterCures’ March 2015 San Francisco San Francisco, CA Consortia-pedia project, which dissects the research-by-collaboration model April 2015 Boston Boston, MA and aims to establish a framework that can be applied broadly. May 2015 Atlanta Atlanta, GA June 2015 Tri-State (CT, NJ, NY) New Canaan, CT September 2015 Chicago Chicago, IL Wired Magazine September 2015 Twin Cities St. Paul, MN The August issue of Wired Magazine carried an article written by Kathy Giusti titled October 2015 New Jersey/New York TBD “Cancer Research: Not a One-Size-Fits-All Approach.” Kathy wrote about recent November 2015 Philadelphia Philadelphia, PA November 2015 Washington, D.C. Fort Washington, MD advances in genome sequencing technologies and super computers making it ® possible to “ferret out the genetic mutations and other molecular abnormalities Clinical Insights in Multiple Myeloma that underlie certain cancers.” Kathy went on to explain that “this information is April 2015 Chairs: Drs. Paul Richardson & Kenneth Anderson Dana-Farber Cancer Institute Boston, MA May 2015 Chair: Drs. Sagar Lonial & Jonathan Kaufman Winship Cancer Center Atlanta, GA June 2015 Chair: Dr. Sundar Jagannath Mt. Sinai Hospital New York, NY one of the most important resources cancer patients can have because it can allow doctors to tailor treatments to the unique aspects of their cancer.” To read more, visit themmrf.org/stories 26 2015 Calendar of Events Fiona An, M.D. Senior Vice President of Clinical Research Daniel Auclair, Ph.D. Vice President of Translational Research Beverly Harrison Vice President of Clinical Operations Anne Quinn Young, M.P.H. Vice President, Development and Strategic Partnerships Honorary Board Dusty Baker Don Baylor James T. Brown Bob Costas Katie Couric Cindy Crawford Ann Curry Clive J. Davis Scott Hamilton Mariska Hargitay Lou Holtz Bonnie Hunt Senator Kay Bailey Hutchison Dan Jansen Hoda Kotb Diana Krall Eric McCormack Deborah Norville Sharon Osbourne Carl Quintanilla Al Roker Mel Stottlemyre Brian Williams Pat Williams Bob Woodruff Lee Woodruff The information herein is not intended to replace the services of trained health professionals (or to be a substitute for medical advice). You are advised to consult with your healthcare professional with regard to matters relating to your health and, in particular, regarding matters which may require diagnosis or medical attention. Copyright ©2014 Multiple Myeloma Research Foundation MMRF I N T HE NE WS T HE MMRF.ORG 27 383 Main Avenue, 5th Floor, Norwalk, CT 06851 we are curing cancer THIS CAMPAIGN WILL ENABLE US TO ACCOMPLISH AS MUCH IN THE NEXT THREE YEARS AS WE HAVE IN THE PAST DECADE. We are fueling the development of treatments that have real promise for patients who don’t have time to waste. We have built a strong foundation and a proven network that is ready to leverage new science and technology to further accelerate success. This is a very special moment in time. The impact of each dollar will be exponentially magnified by our momentum. All of our needs are immediate and the return on the investment will be realized equally fast. PLEASE SUPPORT THE MMRF NOW CAMPAIGN. DONATE AT THEMMRF.ORG GUIDESTAR ®
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