Discover. Synthesize. Analyze. Customize. New Maybridge building blocks Issue 2 - 2015 The availability of diverse and pharmacophorically relevant synthetic building blocks remains a critical success factor in the drug design process. Where key building blocks are not commercially available, in-house synthesis consumes vital time and can add considerable cost to the project. Over the last 50 years, we have built an unparalleled, off-the-shelf collection of building blocks with medicinally important ring systems, many of which are unique to the MaybridgeTM brand. Our primary focus is on heterocyclic chemistry because we believe that such pharmacophore-enhancing molecules are key tools for the drug discovery chemist. We are regularly introducing new products into our portfolio. Discover a selection of the latest compounds now available in the Maybridge building blocks range. New compounds available in the Maybridge building blocks range NH2 NH2 F N O Cl N Product code Product name Purity NP39998CB NP39998DA 4-Amino-2-chloro-5fluoropyrimidine 98% NP39998DE Pack size Product code Product name 250mg NP43803DA 1g NP43803DE Purity 5-Amino-2,3dihydrobenzofuran 97% Pack size 1g 5g 5g O N NH2 N N Product code Product name NP43327DA NP43327DE Purity 3-Amino-6morpholinopyridazine Pack size 1g 97% 5g Product code Product name NP43582DA NP43582DE Purity (R)-(+)-3Aminotetrahydrofuran p-toluenesulfonate salt Pack size 1g 97% 5g Br CO2H N N N S NH2 Product code Product name MO09049DA MO09049DE 5-Amino-1,2,4-thiadiazol CH3 Purity 97% Pack size Product code Product name 1g NP43117DA 5g NP43117DE 5-Bromo-1-methyl-1Hindole-3-carboxylic acid Purity 97% Pack size 1g 5g Discover. Synthesize. Analyze. Customize. New compounds available in the Maybridge building blocks range NH2 Br CF3 N N N N H O Product code Product name NP43804DA NP43804DE Purity 4-Bromo-3-(trifluoromethyl)1H-pyrazole 97% Pack size Product code Product name 1g NP45376DA 5g NP45376DE Purity 1-(2-Chloroethyl)-2pyrrolidone 95% Pack size 1g 5g Cl N O N CH3 Product code Product name NP45412CB NP45412DA CH2NH2 Purity 4-Chloro-6-methylpyrimidine 95% Pack size Product code Product name 250mg NP43266DA 1g NP43266DE CF3 Purity (Chroman-8-ylmethyl)amine 90% Pack size 1g 5g H2N N Cl Product code Product name NP45379CB NP45379DA O Cl N Purity 2,4-Dichloro-6(trifluoromethyl)pyrimidine 95% Pack size Product code Product name 250mg NP43797DA 1g NP43797DE F Ethyl 5-aminobenzo[b]furan2-carboxylate 1g 5g N H Product code Product name Purity 5-Fluoroindole-3-acetic acid 98% Pack size 1g Product code Product name NP44335DA NP44335DE 5-Fluoroindole-3carboxaldehyde 3-Iodo-1H-pyrazole 99% Pack size 1g 5g N N N N H Product code Product name Purity NCO I NP44481DE 97% Pack size CHO N H NP44481DA Purity F CH2CO2H NP39822DA CO2Et CH3 Purity 97% Pack size Product code Product name 1g NP43114DA 5g NP43114DE 4-Isocyanato-1-methyl-1Hpyrazole Purity 95% Pack size 1g 5g 2 Discover. 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New compounds available in the Maybridge building blocks range H3C CH3 CH3 CH3 O O B O N NH2 CH3 N CH3 Product code Product name NP44101DA NP44101DE Purity N-Methylindole-3-boronic acid pinacol ester 97% Pack size Product code Product name 1g NP43246DA 5g NP43246DE Purity 2-Methyl-4-morpholin-4ylaniline 97% Pack size 1g 5g CH3 H3C CH3 CH3 O H3C N B O CHO S N CH3 Product code Product name NP44100DA NP44100DE Purity N-Methylpyrrole-3-boronic acid pinacol ester 90% Pack size Product code Product name 1g NP42935DA 5g NP42935DE Purity 4-Methyl-2thiazolecarboxaldehyde H3C 97% Pack size 1g 5g CH3 N Product code Product name NP42936DA NP42936DE Purity 4-Methyl-1,3-thiazole-2carboxylic acid N F3C CO2H S 97% Pack size N H Product code Product name 1g NP39860DA 5g NP39860DE Purity 3-Methyl-5-(trifluoromethyl) pyrazole H3C CO2H O B O N 99% Pack size 1g 5g CH3 CH3 CH3 N N H N Product code Product name NP44158DA Purity 1H-Pyrazole-3-carboxylic acid 97% Pack size 1g N Product code Product name NP45435CB NP45435DA NH2 2-(Pyrrolidin-1-yl)pyrimidine5-boronic acid pinacol ester Purity 95% Pack size 250mg 1g SO2Cl N N O O Product code Product name NP45357DA NP45357DE 1-Tetrahydropyran-4-yl-1Hpyrazol-4-ylamine Purity 97% Pack size Product code Product name 1g NP42944DA 5g NP42944DE Tetrahydropyran-4-sulfonyl chloride Purity 97% Pack size 1g 5g 3 Discover. Synthesize. Analyze. Customize. Quality, availability and cost effectiveness • All our building blocks are analyzed in-house using one or more of the following techniques: NMR, HPLC, GC and/or IR • With more than 95% stock availability, our product offering provides a speedy and reliable source for high-quality building blocks • Our building blocks are now even more competitively priced, offering excellent value for money Discover our structure search tool at www.maybridge.com to find specific building blocks and check their stock availability. ©2015 Thermo Fisher Scientific Inc. All rights reserved. All other trademarks are the property of Thermo Fisher Scientific Inc. and its subsidiaries. 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