22/10/04 14:21 M I C R O S Parameters Reagents Page 1 C R P : T E C H N I C A L • CBC/DIFF mode: 18 parameters with graphics for RBC, PLT and WBC populations. RBC, WBC, PLT, HGB, HCT, MCV, MCH, MCHC, PCT, MPV, PDW, RDW, Lymphocytes (% and #), Monocytes (% and #), Granulocytes (% and #). • CBC/DIFF + CRP mode: 19 parameters with graphics for RBC, PLT and WBC populations. RBC, WBC, PLT, HGB, HCT, MCV, MCH, MCHC, PCT, MPV, PDW, RDW, Lymphocytes (% and #), Monocytes (% and #), Granulocytes (% and #), CRP. Memory • Last result. Sampling • CBC/DIFF mode: only 10 µL of whole blood. • CBC/DIFF + CRP mode: only 18 µL of whole blood. Calibration • Automatic. Throughput • 70 s (CBC/DIFF mode). • 260 s (CBC/DIFF+CRP mode). Maintenance • Programmable start-up and automatic cleaning cycles. Identification • Numerical keyboard. Printer • 80 column dot matrix printer or thermal printer. • CBC/DIFF mode: Three reagents (diluent, lysing, cleaner). • CBC/DIFF + CRP mode: Six types of reagents (diluent, lysing, cleaner, CRP reagents). Flags • Programmable normal limits. • Pathological flags. Interfacing • RS232 output. Functions • By direct function-keys. Dimensions Weight • 41 x 30 x 40 (H x W x D) cm. • 18 kg. Result display • Through the display unit. Power supply • 90 V to 240 V. • 50 Hz to 60 Hz. Sample processing • On open tube with 4 position tube holder (QC, 500 µL, 3 or 5 mL). Quality control • CBC/DIFF controls (3 levels). • CRP control (2 levels). Principles of measurement Parameters S P E C I F I C AT I O N S • Photometry (HGB). • Immunoturbidimetry (CRP). Within-run precision (CV ) Linearity range Carry-over WBC 2.5 % at 10.109/L 0.5 to 80.109/L 0.5 % RBC 2 % at 5.1012/L 0.2 to 7.5.1012/L 0.5 % Hgb 1.6 % at 15 g/dL 2.5 to 23 g/dL 0.5 % PLT 5 % at 300.109/L 10 to 1 000.109/L 0.5 % Hct 2 % at 45 % 11.6 to 55 % 0.5 % Lymphocytes 5 % at 40 % Monocytes 10 % at 10 % Granulocytes 3 % at 50 % 0.2 to 7 mg/dL 0.1 % CRP 10 % at 1 mg/dL 4% at 5 mg/dL ABX MICROS CRP T H E HAN249C / Subject to technical modifications 0410185CRPGB Compact and fully automated, MICROS CRP provides fast accurate results, including differential screening and CRP level measurement HORIBA ABX INTERNATIONAL (33 / 4 67 14 15 16) - HORIBA ABX - FRANCE (33 / 4 67 14 15 15) - HORIBA ABX - BENELUX (32 / 3 281 49 08) - HORIBA ABX - ITALY (39 / 06 51 59 22 1) HORIBA ABX - SPAIN (34 / 91 353 3010) - HORIBA ABX - PORTUGAL (351 / 2 14 72 17 70) - HORIBA ABX - U.K. (44 / 1462 8144 00) - HORIBA ABX - AUSTRIA (43 / 1 718 78 44 00) HORIBA ABX - POLAND (48 / 22 673 20 22) - HORIBA ABX - USA (1 / 949 453 0500) - HORIBA ABX - BRAZIL (55 / 11 55 45 1500) - GERMANY AXON LAB AG (49 / 7153 92260) ABX ONLINE : http://www.horiba-abx.com in whole blood. P O W E R O F S Y N E R G Y 22/10/04 14:21 Page 2 MICROS CRP EVERY TIME AN EMERGENCY SCREENING IS NECESSARY COMPACT AND FULLY AUTOMATED, MICROS CRP PROVIDES FAST Emergency labs, Rheumatology, ACCURATE RESULTS, INCLUDING DIFFERENTIAL SCREENING AND Pediatrics, Surgery... CRP LEVEL MEASUREMENT IN WHOLE BLOOD. Fast and flexible, combining hematology and immunology in one single instrument, MICROS CRP allows you a global approach: The first analyzer combining blood cell count and analysis with CRP measurement in whole blood. • Screening of the acute phase reaction • Early diagnosis of infectious and inflammatory diseases • Monitoring extent and activity of disease • Diagnostic orientation of leukocytosis and thrombocytosis cases • Improvement of turn-aroundtime RBC, WBC, PLT, HGB, HCT, MCV, MCH, MCHC, PCT, MPV, PDW, RDW, Lymphocytes (% and #), Monocytes (% and #), Granulocytes (% and #) and CRP. Fully automatic, compact and easy to use, MICROS CRP offers you unique performances: • CRP measurement in whole blood • Sampling on primary tube • Differential screening • 18 µL sampling volume • Perfectly suitable for pediatric samples • Extremely quiet (no compressor) • “zero-maintenance” concept TIME AFTER INFLAMMATORY STIMULUS (DAYS) 3.100 CRP 3.000 300 ESR 200 100 0 0 ACCURATE RESULTS AND DIFFERENTIAL SCREENING FLEXIBLE AND EASY TO USE AUTOMATIC AND COMPACT BENCHTOP ANALYZER • 18 hematological parameters • Sampling on K3EDTA tubes, • One button aspiration with + CRP level measurement with 4 position tube holder (QC, 500 µL, 3 or 5 mL) • No pre-dilution step • Automatic cleaning of the sampling needle • Impedance technology + immunoturbidimetry • Sampling on whole blood • Complete selective flagging • Normal limits printed on patient results • Automatic calibration probe wipe • Fully-automatic analysis cycle • One button auto/manual start up and shut down • Simple menu driven system with user prompt • Selectable daily maintenance 7 14 CHANGE IN MEASURED VALUES 0410185CRPGB 21 Characteristic patterns of change in ESR and CRP concentration after an inflammatory stimulus. Following the inflammatory stimulus, CRP concentration increases early, five hours after the onset of acutephase reaction, with a magnitude as much as 1000-fold. Conversely, the ESR rate of change, as well as its dynamic range, is much lower than that of CRP. CLINICAL SETTINGS ASSOCIATED WITH MAJOR ELEVATION OF SERUM CRP CONCENTRATION Infection: • Acute bacterial infections • Systemic fungal infections • Plasmodium (P. falciparum) infection • Systemic Pneumocystis or Toxoplasma infection • Systemic CMV or Herpes virus infection. Inflammatory disease: • Rheumatic fever • Rheumatoid arthritis • Juvenile chronic arthritis • Mediterranean fever • Reiter’s disease • Crohn’s disease • Polymyalgia rheumatica • Systemic vasculitis • Psoriatic arthritis • Ankylosing spondylitis. Malignant neoplasia: • Multiple myeloma • Non-Hodgkin lymphoma • Hodgkin’s disease Necrosis: • Waldenström’s disease • Carcinoma, sarcoma. • Myocardial infarction, acute pancreatitis, tumor embolization. Trauma: • Surgery • Burns • Fractures. Allograft rejection: • Renal transplantation.