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Schedule for Diller Scientific Retreat; March 13th and 14th, 2015
Chaminade Resort and Spa, Santa Cruz
Friday, March 13th
12:00 – 4:00 pm
Registration and refreshments in Seacliff Lounge and Terrace (SLT).
Free time to enjoy outdoor amenities
Lunch can be purchased in the cafe
Poster set up.
Poster Rooms: Capitola, Natural Bridges, Rio Del Mar.
2:30 – 4:00 pm
4.00pm SCIENTIFIC SESSION BEGINS in Santa Cruz Room:
4:00 pm
Opening Remarks – Alan Ashworth
Session 1: 4:00 – 6:10 pm Santa Cruz Room
Chair: Blake Aftab PhD and Ed van Veen PhD
4:10 - 4:30
Gabriele Bergers, PhD
Intertwined regulation of angiogenesis and immunity in cancer 4:30 - 4:50
Rob Bell (Costello Lab)
GABP selectively binds and activates the mutant TERT promoter across multiple
cancer types
4:50 - 5:10
Julia Rohrberg, PhD (Goga Lab)
TPX2 overexpression is essential for the survival of MYC-driven TNBC cells
5:10 - 5:30
Pamela Munster, MD
Novel agents in Phase I development at UCSF
5:30 - 5:50
Peter Westcott (Balmain Lab)
The mutational landscapes of genetic and chemical models of Kras-driven lung
cancer
Boris Bastian, MD, PhD
The Genetic Evolution of Melanoma from Precursor Lesions
5:50 – 6:10
6:10 - 8:00 pm
Dinner Sunset Restaurant. And Express Check-in in SLT
Session 2: 8:00 – 11:00pm
8:00 - 8:30 pm
Chair: Adrian Contreras
Poster Blitz Session I (Santa Cruz Room):
8.00pm
Lee Rivera, PhD (Bergers Lab) Oscillating myeloid cells facilitate PI3Kγ-mediated
resistance to antiangiogenic therapy
8.05pm
Tali Mazor (Costello Lab) Cell cycle signature and tumor phylogeny are encoded in the
evolutionary dynamics of DNA methylation in glioma
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8.10pm
Shirin Ilkhanizadeh, PhD (Weiss Lab) High interstitial fluid pressure regulates tumor
growth and drug uptake in human glioblastoma
8.15pm
Tsun-Wen (Sheene) Yao, PhD (Nicolaides Lab) Feedback Activation of EGFR via
PTPN9 leads to Glioma Escape from BRAFV600E Targeted Therapy
8.20pm
Meng Li, MD, PhD (Goga Lab) Functional annotation of human breast cancer driver
genes in vivo
8:30 - 11:00 pm
Poster Session 1 in Capitola, Natural Bridges, Rio Del Mar, Social, drinks and
snacks in SLT.
Saturday, March 14th
6:30 – 8:30 am
Breakfast Sunset Restaurant and Hotel check out
Session 3: 8:30 – 10:30 am Santa Cruz Room
Chair: Adam de Smith, PhD and Gorjan Hrustanovic
8:30 - 8:50
Trever Bivona, MD, PhD
Improving mechanism-based therapy of lung cancer
8:50 - 9:10
Crystal Conn, PhD (Ruggero Lab)
eIF4E is rate-limiting for the oncogenic cellular stress program but not normal
mammalian development and global protein synthesis
9:10 - 9:30
Nilotpal Roy, PhD (Hebrok Lab)
SWI/SNF subunit Brg1 promotes both tumor suppressive and oncogenic
activities at distinct stages of pancreatic cancer formation
9:30 - 9:50
Scott Oakes, MD
The Unfolded Protein Response: Cancer Friend or Foe?
9:50 - 10:10
Hanna Sabelstrom, PhD (Persson Lab)
SOX9 as a downstream target in Ras/MEK driven pediatric glioma
10:10 - 10:30
Alexei Polishchuk, MD, PhD (Bivona Lab) Unraveling the mechanism of SBRT
response in pulmonary adenocarcinoma with CRISPR/Cas9 functional genomics
Session 4: 10:30 am – 1:45 pm
Chair: Kan Lu PhD
10:30 – 11:00 am
Poster Blitz Session II (Santa Cruz Room):
10.30
Roman Camarda (Goga Lab) Mitochondrial Fatty-Acid Oxidation
Dysregulated in and is Essential for MYC-Driven Basal Breast Cancer
10.35
Xinyuan Lu, PhD (Collisson Lab)
Targeting MET splicing mutations in lung adenocarcinoma
10.40
Mary McMahon, PhD (Ruggero Lab)
Post-transcriptional RNA modifications in translational control and disease
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10.45
Hunter Shain, PhD (Bastian Lab)
Exome sequencing of desmoplastic melanoma reveals recurrent NFKBIE
promoter mutations and diverse MAPK pathway activating mutations
10.50
Seyedmehdi Shojaee, PhD (Muschen Lab)
Erk and Stat5 feedback control enables transformation and represents a
therapeutic target in acute lymphoblastic leukemia
11:00 am – 1:45 pm
Poster Session 2 in Capitola, Natural Bridges, Rio Del Mar
Coffee in SLT
12:30 – 1:45 pm
Lunch Sunset Restaurant
Session 5: 1:45 – 4:00 pm Santa Cruz Room
Chair: Collin Blakely MD PhD and Ana Ruiz-Saenz PhD
1:45 - 2:05
Cathy Park, MD
Tumor microenvironment and stroma in therapy prediction and response
2:05 - 2:25
Matt Hangauer, PhD (McCormick Lab)
Revealing the Survival Mechanisms of Breast Cancer Persister Cells
2:25 - 2:45
Mark Magbanua, PhD (John Park Lab)
Comprehensive molecular profiling of circulating tumor cells (CTCs) from
metastatic breast cancer (MBC) patients
2:45 - 3:05
Adil Daud, MD
PD-1 antibodies in melanoma: building a better Biomarker
3:05 - 3:25
Zhengshan Chen, MD, PhD (Muschen Lab)
Signalling thresholds and negative B-cell selection in acute lymphoblastic
leukaemia.
3:25 – 3:45
Lewis Lanier, PhD
Tumor evasion of Natural Killer cell immune surveillance
3:45 – 4:00
Alan Ashworth Final Remarks:
Prize Awards: Best Posters and Best Talks
4:00 pm
Coffee in SLT and Conclusion of Meeting
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