1. health and fitness
2. disease

Eleventh Annual Senior
Scholarship Day
&
Charles R. Drew
University of Medicine and Science
Thursday, March 19, 2015
Covel Commons, Grand Horizon Room
Northwest Auditorium
Conference Moderator: Margaret L. Stuber, MD
Assistant Dean of Student Affairs for Career Development and Well-Being
Vice Chair for Education in Psychiatry
Daniel X. Freedman Professor, Psychiatry and Biobehavioral Sciences
David Geffen School of Medicine at UCLA
Table of Contents
Schedule ............................................................................................................................ 2
Concurrent Poster Session Schedule ............................................................................ 3
BASIC SCIENCE OF MEDICINE..............................................................................................3
CARDIOLOGY ……………………….................................................................................................3
DIABETES, WEIGHT-LOSS and GI I…………...........................................................................4
DIABETES, WEIGHT-LOSS and GI II....………..........................................................................4
EDUCATION I.............................................................................................................................4
EDUCATION II………..................................................................................................................5
EMERGENCY MEDICINE…….....................................................................................................5
GLOBAL HEALTH……………………………………………………………………………………….6
HEALTH CARE DELIVERY…......................................................................................................6
HEALTHCARE POLICY...............................................................................................................6
HEMATOLOGY………………………………………………………………………………………….7
INFECTIOUS DISEASE..............................................................................................................7
NEUROLOGY.............................................................................................................................7
OB-GYN ………………................................................................................................................8
OB-GYN…………………………………………………………………………………………………..8
ONCOLOGY I .............................................................................................................................8
OPHTHALMOLOGY ...................................................................................................................9
ORTHOPEDICS I …………………................................................................................................9
ORTHOPEDICS II.......................................................................................................................9
PEDIATRICS I........................................................................................................................... 10
PEDIATRICS II.............................................................................................................................10
PSYCHIATRY............................................................................................................................ 10
PUBLIC HEALTH I: ................................................................................................................... 11
PUBLIC HEALTH II: ……........................................................................................................... .11
THORACIC & VASCULAR SURGERY........................................................................................11
UROLOGY...................................................................................................................................11
ANNOUNCEMENT……………………………………………………………………………………...12
Oral Plenary Session Schedule ....................................................................................... 13
Sudeep Banerjee: A Computed Tomography Radiogenomic Biomarker Predicts Microvascular Invasion
and Clinical Outcomes in Hepatocellular Carcinoma…………………………………………………..…..14
Brittany J. Dixon: Does behavioral health integration and recognition as a patient-centered medical
home improve delivery of care within the safety net system?............................................................ 14
Victoria Ho: Post-transcriptional gene regulation in mature neurons…………………… ....... 15
Lydia N. Lo: Hypoglycemia: A Rare Cause of Pediatric Seizures in Pre-Hospital Care ……………...15
Alicia Morehead-Gee: Factors Contributing to Depression among HIV-Positive and HIV-Negative
Latino and African-Americans Residing in South Los Angeles......................................... 16
Schedule
8:30 – 9:00 am
Check-In & Breakfast
Covel Commons, Grand Horizon Room, 2nd level
9:00 – 9:30 am
Poster Set-Up & Viewing
9:30 – 11:00 am
Concurrent Poster Sessions
11:15 – 12:15 pm
Oral Plenary Session
Covel Commons, Grand Horizon Room, 2nd level
Northwest Auditorium
12:15 – 12:30 pm
Students travel back to remove posters no later than 12:30 pm
2
Concurrent Poster Session Schedule
Covel Commons-Grand Horizon Room
BASIC SCIENCE OF MEDICINE
Moderator: Sally Krasne, PhD
Poster
Student
1
Chan, Eric
2
Hu, Shirley
3
Istrin, Joshua
4
Minkovsky, Alissa
5
Knowles, Scott
6
Scapa, Jason
Topic
Evaluation of Epithelial Changes in Limbal Stem Cell Deficiency Using in Vivo Confocal
Microscopy
Investigation of putative IRES structures in truncated p110 ERBB2
Sex differences in the relationship between trait resiliency and the intrinsic connectivity of the
salience and default mode networks
A High-throughput Screen of X Chromosome Inactivation Identifies a Novel Drug
Combination to Enhance Silenced Gene Reactivation by 5-aza-2’-dC
PSCA Minibody for immunoPET Imaging of Prostate and Pancreatic Cancer
Investigating the Role of Macrophage Recruitment in Benign Prostatic Hyperplasia
CARDIOLOGY
Moderator: Gary Satou, MD
7
Amble, Catherine
Predictive factors of 30-day readmissions for heart failure patients: site comparison
8
Brugger, Michelle
The Obesity Paradox in Heart Failure: Associations of Body Fat Mass and Lean Body Mass
with Increased Survival
9
Kern, Tyler
Effect of care transition interventions on different heart failure patient subgroups, defined by
underlying etiology: Are there identifiable subgroups more likely to benefit?
10
Rostomian, Ara
100% Statin Compliance
11
Choi, Young
The incidence of pulmonary hypertension in psoriasis
3
Concurrent Poster Sessions - continued
Covel Commons-Grand Horizon Room
DIABETES, WEIGHT-LOSS, and GI- I
Poster
Moderator: Greg Brent, MD
Student
Topic
Arroyo, Jeffrey
Are there gaps in self-reported and objectively measured physical activity in U.S. adult diabetic
patients: A racial comparison
12
Colonoscopy Mobile App Pilot Study
13
Chang, Jiwoon
14
Park, Sarah
The Workup of Cushing's Syndrome: Illustrated through a Case of Ectopic ACTH-Dependent
Hypercortisolism
Surapaneni, Nirmala
Diabetic muscle infarction
Vu, Kim
Primary Sleeve Gastrectomy Compared to Sleeve Gastrectomy as Revisional Surgery: Weight Loss
and Complications at Intermediate Follow-up
15
16
DIABETES, WEIGHT-LOSS, and GI- II
Moderator: Angela Leung, MD
17
Ali, Saima
A New Digital Histopathology Approach for Quantifying Liver Fibrosis in Patients with Nonalcoholic Steatohepatitis
18
Andre, Mark
Diabetes Intervention in a Homeless Population
19
Lee, Heajung
Ten Years at a Large Liver Transplant Center: Routine, Non-Invasive Serologies are Predictive of
Significant Fibrosis in Hepatitis C Patients Following Liver Transplantation
20
Lentz, Jacob
A New Digital Histopathology Approach for Quantifying Liver Fibrosis in Patients with Viral
Hepatitis C
21
Ngaou, Huy
Diabetic Retinal Screening Rates at the Venice Family Clinic
EDUCATION I
Moderator: Anju Relan, PhD
22
Cuk, Natasha
Working to reduce adverse events in patients that are "handed off"
23
Guzman, Carlos
Extending Anatomical Didactics for the medical student beyond the first year: do long term career
goals matter for the Drew cohort?
24
Harrison, David
Utility and efficacy of a peer-based anatomy tutoring program for first-year medical students: updated
data from the 2013-2014 academic year
25
Lam, Helen
Developing an Online Antibiotics Educational Module for Medical Students
26
Quant, Cara
Survey of Medical Students and Medical Professionals on the Use of Information Technology in the
Practice of Medicine
27
Smith, Jeremy
Publication of Results of Abstracts Presented at Simulation Conferences
28
Taon, Matthew Czar
Randomized controlled study to evaluate whether the use of Google Glass wearable technology can
improve medical student and resident stimulation-based training in Ultrasound-Guided Anesthesia
4
Concurrent Poster Sessions - continued
Covel Commons-Grand Horizon Room
EDUCATION II
Poster
29
Student
Baustista, Alejandra
Moderator: Sarika Thakur, Ed.D.
Topic
Interventions for Depression in Medical Students: A Review of the Literature
30
Chung, Melody
A student-driven initiative to identify and address medical student mistreatment on clinical
clerkships
31
Croymans, Daniel
UCLA Wellbeing Initiative by Student Engagement (U-WISE) Project: Evaluating the
Wellbeing of the UCLA DGSOM Student Body
32
Cun, Tony
Trends in Increasing Clinical Time in Medical School Curricula
33
Hoang, Alexander
4th Year-itis
34
Larsen, Tyler
A comparison of simulation-based education and problem-based learning in pre-clinical
medical undergraduates
35
Laufer, Danielle
36
Magbegor, Wemo
Effectiveness of hemodynamics simulator in teaching medical students about the
treatment of shock compared to traditional didactic methods
Does the medical school curriculum prepare students to effectively cope with the
clinical years of medical school
EMERGENCY MEDICINE
Moderator: Michelle Zeidler, M.D.
37
Azukawa, Hiroko
Bandage Contact Lenses to Decrease Pain and Improve Healing in Emergency Department
Subjects Presenting with Corneal Abrasions
38
Haeffele, Cathryn
Ultrasound Measurement of the Inferior Vena Cava to Evaluate Volume Status in Patients
Requiring Fluid Resuscitation in Limited-Resource Settings
39
Salah, Ramy
Outcomes of a Protocol for Early Evaluation of Shock using Bedside Ultrasound at UCLA:
The RUSH Protocol
40
Smogorzewski, Jan
Lichen Amyloidosis in an Atypical Location
41
Wolday, Feven
Spontaneous Atraumatic Splenic Rupture in a Alcoholic Male Patient: A Case
Report
42
Yee, Lisa
The RUSH exam: Rapid Ultrasound in SHock in the evaluation of MICU patients
43
Yu, Chuck
Goldsheet QI ED
44
Zhu, Lisa
RUSH (Rapid Ultrasound in SHock) Trial
5
Concurrent Poster Session - continued
Covel Commons-Grand Horizon Room
GLOBAL HEALTH
Moderator: Thomas Coates, Ph.D.
Topic
Poster
45
Student
Cambou, Mary
46
Foulad, David
Hypertension Prevalence in Rural Haiti
47
Goldstein, Max Dean
Recurring Fevers: Malaria and the Quinine Trade in the Early Americas
48
Park, Hayoung
Recent syphilis infection among high-risk men who have sex with men (MSM) in Lima, Peru
49
Zorian, Aline
A descriptive analysis of disease burden encountered during a two-week student global
health experience in urban and rural Haiti
Anal Human Papillomavirus (HPV) Prevalences and Factors Associated with Abnormal
Anal Cytology in HIV-Infected Women in an Urban Cohort from Rio de Janeiro, Brazil
HEALTHCARE DELIVERY
Moderator: Shahrzad Bazargan-Hejazi, Ph.D.
50
Goldstein, Zachary
51
Henderson, Geoffrey
Increasing Health Literary in the Geriatric Population: A Program at Vintage Westwood
Horizons, an Independent Senior Living Facility
52
53
Mendez-Kohlieber,
Cynthia
Riveros, Toni
A Retrospective Study of the Impact of Group Visits with Peer-to-Peer Support for Patients
with Diabetes
TeamSTEPPS: Supporting Leadership and Communication at Harbor-UCLA
54
Solorio, Veronica
Reducing Avoidable Admissions in a Brooklyn Hospital
55
Thang, Christine
Improving the Process for Obtaining Hospital Discharge Follow-up Appointments
56
Zhang, Lujia
A Systematic Literature Review of Appointment Reminder Systems
Is There Adequate Communication Between the Primary and Dermatology Consult Team?
HEALTHCARE POLICY
57
Clarke, Lenorre
58
Gonzalez, Erik
59
Kalsi, Sangeeta
60
Lunderville, Chantal
McIntosh, Adam
Moderator: Gerardo Moreno, M.D.
Reducing Consumption of Sugar-Sweetened Beverages in Los Angeles County
The Affordable Care Act and Colorectal Cancer Screening at a Federally Qualified Health
Center
Assessing the Potential for Implementation and Spread of Interdisciplinary Primary Care for
Older Adults
Using Policy to Address Obesity in Los Angeles County: The Case of Sugar Sweetened
Beverages (SSB)
Choosing Primary Care: A View from System Dynamics
61
Sanaiha, Yas
62
Rates of diverting ileostomy in patients undergoing Low Anterior Resection for Colorectal
Cancer at Olive View Medical Center
6
Concurrent Poster Session – continued
Covel Commons-Grand Horizon Room
HEMATOLOGY
Poster
Student
Moderator: Jason Napolitano, MD
Topic
63
Kita, Ashley
Solute Flux as a Quantitative Permeability Measure in a Stem Cell Derived Laryngeal Mucosal
Replacement
64
Blum, Steven
TCR use and cytokine response in PD-1 blockade
65
Kohn, Lisa
Human Lymphoid Development in the Absence of Common ?-Chain Receptor Signaling
66
Nobori, Alex
Comparison of automated solid phase and manual tube DAT testing for detection of
clinically significant immune mediated hemolysis
67
Silva, Oscar
Acute Dlg1 knockout prevents optimal T cell activation, effector function and differentiation in
CD8+ T cells
68
Strength, Kristen
Assessment of length of hospitalization and hospital readmission among patients at risk for
sepsis in the postoperative setting
69
Zhao, Jimmy
Conversion of danger signals into cytokine signals by hematopoietic stem and progenitor cells
for regulation of stress-induced hematopoiesis
INFECTIOUS DISEASE
Moderator: Timothy F. Brewer, MD, MPH
70
Baweja, Abinav
Oral Thrush? Not So Much.
71
Bechtold, Hannah
Streptococcus salivarius: An unusual but important cause of bacterial meningitis
72
Ferguson, Jessica
Increases in Life Expectancy in the Elderly by Treating Chronic Hepatitis C Infection
73
Isnasious, Sandra
West Nile Encephalitis Case Presentation
74
Jankovic, Ivana
75
Pena, Jonathan Dell
Cat Bugs vs. Brain Cancer: The Diagnostic Difficulties of Distinguishing Between Toxoplasma
Encephalitis and Primary CNS Lymphoma in an AIDS Patient
lmonary Hyalinizing Granuloma in a Veteran with Latent Tuberculosis and Agent Orange
Exposure
76
Tong, Lana
Viral infections in acute graft-versus-host disease: A review of diagnostic and therapeutic
approaches
77
Zhang, Alice
West Nile Encephalitis Presenting with Opsoclonus
NEUROLOGY
Poster
78
Student
Cheok, Stephanie
Moderator: Shaun A. Hussain, M.D.,MS
Topic
Basis of Management of Tethered Cord in Spinal Lipomas
79
Cross, Kathryn
Shared neural systems for observing and performing actions: functional connectivity &
implications for neurorehabilitation
80
Hazboun, Michael
Case Report: Refractory status epilepticus as a presentation of PRES in a pediatric liver
transplant patient
81
O’Donnell, Kelley
Axon degeneration and PGC-1alpha-mediated protection in alpha-synuclein toxicity
82
Sozmen, Elif
Collateral Advantage: Complete Reversal of Clinical Deficits in Acute Ischemic Stroke due
to Bilateral Middle Cerebral Artery Occlusion
7
Concurrent Poster Session - continued
Covel Commons-Grand Horizon
OB-GYN I
Moderator: Tony Kuo, M.D.
83
Cham, Stephanie
Severe anemia in the post-partum patient – Mom or Baby to blame?
84
Echevarria, Dina
Intra Aortic Balloon Occlusion during Cesarean Hysterectomy for Placenta Increta
85
Huang, Katherine
Pregnancy-related mobile application usage: A Cross Sectional Study
86
Rose, Kelsey
Impact of an Educational Video Intervention on Perceived IUD Knowledge
87
Shull, Hannah
Prevalence of curable sexually transmitted infections in pregnant women in low- and middleincome countries: A systematic review
OB-GYN II
Moderator: Ed Ha, M.D.
88
Getachew, Ruth
Active Versus Expectant Management of Intrahepatic Cholestasis of Pregnancy: A Systematic
Review
89
Maykin, Melanie
Validation of the Prediction Model for Success of Vaginal Birth After Cesarean Delivery in
Patients Delivering at Ronald Reagan UCLA Medical Center
90
Medina, Wendy
Timeliness of abnormal screening mammography follow-up at Venice Family Clinic
91
Perkins, Colby
Transvaginal Mesh Litigation Trends: An Analysis of Cases
92
Strong, Barbara
Epidemiology and Etiology of Intrahepatic Cholestasis of Pregnancy
ONCOLOGY
Moderator: Mitchell Kamrava, M.D.
93
Gibson, Amanda
Evaluation of Response to Progestin Treatment in Lynch Syndrome Patients with Complex
Atypical Hyperplasia and/or Well differentiated Endometrial Carcinoma
94
Hobbs, Evthokia
New Directions in the Neoadjuvant Treatment of HER2+ Breast Cancer New Directions in the
Neoadjuvant Treatment of HER2+ Breast Cancer
95
Higgins, Shauna
Calciphylaxis and Hypotension: Report of a Case and Review of the Literature
96
Kwon, Daniel
Physician-Reported Barriers to Referring Cancer Patients to Specialists: Prevalence, Factors, and
Association With Career Satisfaction
97
Norberg, Adam
Carcinoma Erysipeloides: Recurrent Metastatic Breast Carcinoma Mimicking Infectious
Dermatitis
98
Spasic, Marko
Stereotactic Radiation for the Treatment of Vestibular Schwannoma: Tumor Control and
Hearing Preservation
99
Yaghoubian, Alan
Adoptive Transfer Immunotherapy Targeting NY-ESO-1 for Treatment of Glioblastoma
8
Concurrent Poster Session - continued
Covel Commons-Grand Horizon Room
OPHTHALMOLOGY
Moderator: Lynn Gordon, M.D., PhD
100
Ashraf, Davin
Longitudinal Cohort Study of Patients with Birdshot Chorioretinopathy: Quality of Life
During 5 Years of Follow-up
101
Chen, Andrew
Models of Glaucomatous Visual Field Loss
102
Fors, Darron
Severe Choroidal Hemorrhage Outcomes and the Effect of Early Intervention Facilitated by
Tissue Plasminogen Activator
103
Garg, Elisha
Intravitreal Anti-VEGF for Radiation Retinopathy Following Iodine-125 Brachytherapy for the
Treatment of Choroidal Melanoma
104
Gupta, Kishan
Ocular Melanoma GEP Class does not Predict Tumor Height Regression Speed after
Brachytherapy
105
Lee, Patrick
Effects of visual noise on binocular summation in strabismic patients without amblyopia
106
Roberts, Kristofer
Quantitative Multiparametric MRI in Uveal Melanoma
ORTHOPEDICS I
Moderator: Jonathan R. Hiatt, MD
107
Awad, Taysir
Twenty-eight year hip survivorship and outcomes of patients treated with a periacetabular
osteotomy for acetabular dysplasia
108
Balcescu, Cristian
Early Results of a Modular Cementless Tibial Component for Total Knee Arthroplasty
109
Burke, Zach
The Role of Chairman and Research Director in Influencing Scholarly Productivity and
Research Funding in Academic Orthopaedic Surgery
110
Kadri, Omar
Twenty-eight year hip survivorship and outcomes of patients treated with a periacetabular
osteotomy for acetabular dysplasia
111
Natsuhara, Kyle
What Is the Frequency of Vascular Injury After Knee Dislocation?
ORTHOPEDICS II
Moderator: Isaac Yang, M.D.
112
Chen, James
Implant Cost Awareness of Analogous Intramedullary and Plate Devices among Orthopedic
Surgeons and Residents in a Public University Hospital
113
Elsissy, Joseph
Wear patterns of hip resurfacing arthroplasty retrievals demonstrate impingement and
subluxation are common
114
Nassiri, Nima
Arthroscopic versus Open Surgical Repair of Anterior Shoulder Instability in Overhead
Athletes
115
Rugg, Caitlin
The Impact of Prior Upper Extremity Surgery on Orthopaedic Injury and Surgery in
Collegiate Athletes
116
Takamura, Karren
Highly Cross-Linked Polyethylene in Hip Resurfacing Arthroplasty: Long Term Follow-up
9
Concurrent Poster Session - continued
Covel Commons-Grand Horizon Room
PEDIATRICS I
Moderator: Rebecca Dudovitz, M.D.
117
Carballo, Nancy
Effects of Alcohol on U.S. Adolescent Sleep Patterns: A Systematic Review
118
Cui, Li
Sensitivity of Plain Radiography for Pediatric Cervical Spine Injury
119
Garg, Dave
Effect of Intravenous Acetaminophen on Pediatric Tonsillectomy and Adenoidectomy
Narcotic Requirements
120
Furukawa, Daisuke
Analysis of Associated Symptoms and Clinician Awareness of Sleep Disturbance in SportsRelated Concussion in Children
121
Oh, Taemin
Maximum Safe Surgical Resection Provides Best Clinical Outcomes for Intramedullary
Astrocytomas in Pediatric Patients
122
Shah, Shaishav
Effect of Intraoperative Acetaminophen on Pediatric Tonsillectomy Post-operative Recovery
Time and Pain
PEDIATRICS I
Moderator: Jennifer Sucre, M.D.
123
Diep, Thuan
Comparing peer and adult social networks inside and out of school in bullying for inner-city
adolescents
124
McCoy, Kelsi
Evaluation of School Based Wellness Centers
125
Moss, Tanesha
Low-Income Parents' Views on a New Model for well Child care redesign
126
Ramirez, Carmen
Pediatric stroke: A case report of Antiphospholipid Antibody Syndrome induced stroke as a
manifestation of newly diagnosed SLE
127
Russell, Christine
The Necessity of an Interdisciplinary Curriculum for Inner City Teens: Evaluating Athletics,
Music Education Programs and Health Utilization
128
Snider, Samantha
School-Sponsored Activities & Their Relation to Marijuana Use Among Los Angeles Latino
Teens
PSYCHIATRY
129
Alexander-Bloch, Aaron
130
Ben-Ghaly, Lubabah
131
Eng, Kevin
132
Kho, Christine
133
Lee, Eun Kyung
134
Masukawa, Kristin
135
Rodriguez, Johana
Moderator: Erica Nurmi, M.D., PhD
Functional and structural MRI of brain networks in typical development and childhood-onset
schizophrenia
Neuroleptic Malignant Syndrome: Case Report and Review of Current Treatments
Knowledge of dementia community resources and stigma among Chinese American
immigrants
Breast and Colorectal Cancer Screening in the Mentally Ill: Results from the 2009 California
Health Interview Survey
Assessment of mental health need in Korean youth population and stigma within the
community as assessed by Korean Youth Pastors.
Older Adults Visit Online Sites for Screening and Brief Intervention for Unhealthy Alcohol
Use
Mental Health Literacy about Depression and Anxiety among Low-income Latino Women:
The Effects of Integrating a Sustainable Multi-component Prevention Program in a
Community Setting
10
Concurrent Poster Session - continued
Covel Commons-Grand Horizon Room
PUBLIC HEALTH I
Moderator: Daphne Calmes, M.D.,
136
Chen, Katherine
137
Li, Eric
138
Espinoza-Setchko, Bo
The Role of Network Adequacy and Essential Community Providers in Delivering Care to
Underserved Populations: A South Los Angeles Study
139
Nafiz, Rayek
SBIRT Implementation at UCLA IMS Clinic
140
Mangubat, Michael
Role of acculturation in determining pre-operative anesthesia-related concerns
Urban agriculture: potential response of a resourceful community to living in a “food
desert”
Perceptions of the ACA in the homeless population
PUBLIC HEALTH II
Moderator: Lawrence ‘Hy’ Doyle, Ed.D.
141
Gonzalez, Karla
Ideas and Opinions of Older Latinos On Aggressive Treatments
142
Khalili, Josh
Identifying LGBT-Competent Physicians Nationally: A Follow-up Study
143
Padilla, Guillermo
144
Sunjaya, Dharma
The Affordable Care Act and Colorectal Cancer Screening at a Federally Qualified Health
Center
Factors Affecting Diabetes Mellitus Care in the United States
145
Weintraub, Gil
Allergic Contact Dermatitis Database Review
THORACIC AND VASCULARY SURGERY
Moderator: Chris DeVirgilio, M.D.
146
Abdulla, Amer
Outcomes of Surgery for Primary Hyperparathyroidism: Analysis of 17,082 Cases
147
Khoo, Teresa
Massive Pulmonary Embolism
148
Klausner, Jill
The Contemporary Management of Renal Artery Aneurysms
149
Lancaster, Elizabeth
Long Term Outcomes of Abdominal Aortic Aneurysm Repair in the Veteran Population
150
Maciel, James
Predictors of Mortality in Patients with Penetrating Injuries of the Inferior Vena Cava
Surviving to the Operating Room
151
Nguyen, Virginia
Symptomatic Common Femoral Artery Elongation and Kinking in a Cyclist
152
Tse, Brian
Comparing levels of glucose using an insulin infusion protocol vs. conventional
intraoperative glucose management during cardiac surgery with cardiopulmonary bypass
153
Tse, Justin
Removing vocal fold epithelium impairs vibration in an excised larynx model
UROLOGY
Moderator: Gerald Lipshutz, M.D.
154
Elbuluk, Osama
Correlating ADC with Prostate Cancer Aggressiveness using 3T Multiparametric-MRI
155
Greenburg, Scott
Literature Review and Case Report: Pemphigoid as a Rare Urologic Paraneoplastic
Presentation
156
Moradzadeh, Ariel
Review of studies and review papers related to Tadalafil daily use for the treatment of Erectile
dysfunction, with or without LUTS, from 2011 to current
157
Shkolyar, Eugene
158
159
Slupski, Victor
Zaki, Michael
Comparison of Multi-Parametric MRI Performance for Cancer Detection Between the Central
and Peripheral Prostate
Testicular tumor presenting with massive deep venous thrombosis
Unusual Presentation of Metastatic Prostate Carcinoma as Neck Mass
11
Charles R. Drew University of Medicine
and Science
CDU/UCLA Medical Education Program
The Medical Student Research Thesis Program
(MSRTP) Presents
The Class of 2015
Medical Student Research Colloquium Current Research in
Health Disparities Wednesday, March 25, 2015
8:30 AM to 4:30 PM
Registration begins at 7:30 a.m.
Keck Auditorium
Charles R. Drew University of Medicine and Science
1731 East 120th Street
Shahrzad Bazargan-Hejazi, PhD
[email protected]
Stacey Teruya, EdD, MS
[email protected]
12
Northwest Auditorium
11:15 am – 12:15 pm
Student presentations are 7 minutes in length
followed by a 4 minute question and answer period
Speaker
Order
Student
Moderator: Alison A. Moore, MD
Mentor
Presentation
Michael Kuo, M.D.
A Computed Tomography Radiogenomic Biomarker Predicts
Microvascular Invasion and Clinical Outcomes in Hepatocellular
Carcinoma
Dixon,
Brittany J.
Nadereh Pourat, M.D.
Does behavioral health integration and recognition as a patientcentered medical home improve delivery of care within the safety
net system?
3
Ho, Victoria
Kelsey Martin, M.D.
Post-transcriptional gene regulation in mature neurons
4
Lo, Lydia N.
Andrea Rapkin, M.D.
5
Morehead-Gee,
Alicia
Cynthia Davis, MPH
1
Banerjee, Sudeep
2
Impact of Vulvodynia on Sexual Function: Data from a Nationwide
Registry
Factors Contributing to Depression among HIV-Positive and HIVNegative Latinos and African-Americans Residing in South Los
Angeles
13
Oral Presentation Abstracts
Sudeep Banerjee:
Case Study: A Computed Tomography Radiogenomic Biomarker Predicts
Microvascular Invasion and Clinical Outcomes in Hepatocellular Carcinoma
Introduction: Microvascular invasion (MVI) in hepatocellular carcinoma (HCC) is an independent predictor of
poor outcomes following surgical resection or liver transplantation (LT); however, MVI currently cannot be
adequately determined preoperatively. Radiogenomic venous invasion (RVI) is a contrast-enhanced computed
tomography (CECT) biomarker of MVI derived from a 91-gene HCC "venous invasion" gene expression signature.
Methods: Preoperative CECTs of 157 HCC patients who underwent surgical resection (N = 72) or LT (N = 85)
between 2000 and 2009 at 3 institutions were evaluated for the presence or absence of RVI. RVI was assessed for its
ability to predict MVI and outcomes. Interobserver agreement for scoring RVI was substantial among 5 radiologists
(k=0.705, P<0.001).
Results: The diagnostic accuracy, sensitivity and specificity of RVI in predicting MVI were 89%, 76% and 94%,
respectively. Positive RVI score was associated with lower overall survival than negative RVI score in the overall
cohort (P<0.001; 48 vs. >147 months), AJCC-TNM stage II (P<0.001, 34 vs. >147 months), and in LT patients within
Milan criteria (P<0.001; 69 vs. >147 months). Positive RVI score also portended lower recurrence-free survival at 3years versus negative RVI score (P=0.001; 27% vs. 62%).
Conclusion: RVI is a noninvasive radiogenomic biomarker that accurately predicts histologic MVI in HCC
surgical candidates. Its presence on preoperative CECT is associated with early disease recurrence and poor overall
survival and may be useful for identifying patients less likely to derive a durable benefit from surgical treatment.
Brittany J. Dixon: Does behavioral health integration and recognition as a patient-centered medical home improve
delivery of care within the safety net system?
Objective: Adoption of patient-centered medical home (PCMH) recognition and behavioral health integration among
community clinics has accelerated since the implementation of the Affordable Care Act (ACA). The ACA aims to improve
patients’ health and the quality of care delivered while simultaneously decreasing costs. This study examines the effect of
PCMH recognition and behavioral health integration on service use of enrollees in the Low Income Health Program (LIHP),
which was established by a Medicaid 1115 waiver and implemented over seven quarters (January 2011 - December 2013) in 53
California counties.
Methods: PCMH recognized community clinics that employed behavioral health (BH) care providers and provided publicly
available LIHP data were selected. LIPH enrollees (total N=48,666 in 37 clinics; had BH diagnosis N=16,847) were selected from
41 counties. Random effects Poisson was utilized to examine change over time in service use, which included evaluation and
management visits (E&M), emergency room visits, and hospitalizations.
Results: The adjusted rate of E&M visits (1.3 to 0.9), ER visits (0.19 to 0.15), and hospitalizations (0.09 to 0.04) decreased for
PCMH enrollees during this time. Enrollees with BH diagnosis in PCMH clinics with BH employees experienced the highest
drop in adjusted E&M visit rates (1.59 to 1.24 visits/person). Those with PCMH, but no BH employees experienced decreased
utilization, but it was less steep. Clinics without PCMH, but with BH employees had the least steep drop in the rates of E&M
visits.
Conclusions: PCMH recognition significantly reduced the rates of E&M visits, emergency room visits, and hospitalizations
during this time period. BH integration decreased E&M visits, but did not have an independent impact from PCMH on
emergency visits or hospitalizations.
Implications for Policy: PCMH recognition and BH integration may promote cost savings through decreased
utilization. BH integration and PCMH recognition appear to directly benefit Medicaid programs.
14
Victoria Ho:
Post-transcriptional gene regulation in mature neurons
Introduction: Neurons are highly-polarized cells with processes that span great distances and many
independent subcompartments. Despite their challenging morphology, neurons are able to respond to external
stimuli in a local or cell-wide manner. They are also able to form stable connections with other neurons, while
remaining plastic and adaptable to change. To meet these demands, neurons use complex, post-transcriptional
mechanisms to regulate gene expression. Two approaches were taken to study these mechanisms.
Methods: First, a cell biological approach was used to study a specific interaction between the microRNA, miR124, and GluA2 mRNA in dissociated hippocampal neurons. Using biochemical fractionation, fluorescence in situ
hybridization, immunoblotting, and immunocytochemistry, we found that miR-124 is dendritically-localized while
GluA2 mRNA is somatically-restricted. Both RNAs are present in the cell body, where they interact to
downregulate GluA2 proteins in the soma by ~30 %. Synaptic GluA2 protein was not affected by this
manipulation, suggesting that post-translational regulatory mechanisms (e.g. trafficking) are in place to maintain
appropriate concentrations of GluA2 at the synapse.
Methods: Second, a high-throughput sequencing approach was taken to identify general mechanisms of gene
regulation during chemical long-term potentiation (chemLTP) in acute hippocampal slices, as well as to screen for
interesting candidates for further investigation. RNA was extracted from chemLTP-treated and control slices, and
changes in steady-state RNA levels were determined.
Results: This study is ongoing but so far, preliminary results suggest that non-neuronal cells may play an
important role in the strengthening of neuronal connections. Future analysis will focus on 3’ untranslated regions,
which determine the post-transcriptional fate of genes.
Conclusion: The two approaches provide different levels of information on the regulation of gene expression in
neurons and yield unexpected findings. Together, they illustrate the complexity of regulatory mechanisms in
neurons, and that there is much we have left to understand.
Lydia N. Lo: Impact of Vulvodynia on Sexual Function: Data from a Nationwide Registry
Background: Vulvodynia is a poorly-understood chronic pain disorder of unknown etiology. The National Vulvodynia
Registry is a multi-site, national registry of more than 200 patients with vulvodynia that contains clinical examination data, as
well as questionnaire data on a variety of other aspects, including medical comorbidities and quality of life. One of the
interesting findings form this database is how vulvar pain correlates with sexual functioning.
Methods: Cleaned data was analyzed using STATA. The outcomes of interest are two clinical pain scores summarizing pain
in the mucosa of the vestibule and also pain with muscle activation in the vulva. Sexual function was assessed using the Female
Sexual Function Index (FSFI) and other quality of life questions.
Results: Both mucosal and muscle pain scores had strong correlations with factors associated with components of sexual
activity. For instance, both mucosal and muscle pain is negatively correlated with arousal (frequency of, level of, confidence
with, and satisfaction with) and orgasm (frequency of, difficulty of achieving, and satisfaction with ability to achieve), and
negatively correlated with overall satisfaction with sex life. However, there were no significant correlations between mucosal
and muscle pain scores and factors outside of sexual activity itself that addressed more broadly the patient’s relationship with
her partner. We found no relationship between pain and frequency of intercourse, whether or not vulvodynia affected the
patient’s relationship with her partner, the degree of support the patient received from her partner post-diagnosis, or the level
of intimacy between the patient and her partner.
Conclusion: This information suggests that, while vulvodynia negatively affects sexual activity, it has much less of an
impact on a patient’s relationship with her partner. More information is needed on how women cope with increased difficulty
with sex while maintaining relationships.
15
Alicia Morehead-Gee: Factors Contributing to Depression among HIV-Positive and HIV-Negative Latinos
and African-Americans Residing in South Los Angeles
Background: The prevalence of depression among HIV-positive individuals is twice that of HIV-negative
individuals. Few studies have investigated risk factors for depression among HIV-positive and HIV-negative
Latinos and African-Americans.
Objective: To compare depression prevalence among HIV-positive and HIV-negative Latinos and AfricanAmericans in South Los Angeles and examine how alcohol abuse, childhood sexual abuse (CSA), and HIV/AIDS
knowledge influence depression status.
Methods: Cross-sectional data were collected over two years. Subjects were recruited at community outreach sites
and HIV/AIDS Primary Care Clinics. Preliminary analysis of depression by demographics, HIV status, alcohol
abuse, CSA, and HIV/AIDS knowledge was done using SPSS 22.
Results: Of the 168 participants, 61% were Latino, 35% were African-American, 54% were male, 63% had an
income under $10,000/year, 53% were depressed, 69% had experienced CSA, 55% screened positive for alcohol
abuse, and 12% were HIV-positive. There was no significant difference in depression between HIV-positive (74%)
and HIV-negative (51%) participants (p>0.05). Depression was significantly higher in males, Latinos, participants
with income under $10,000, those with history of CSA, and those who abused alcohol (p<0.05) compared to the
other groups. Compared to HIV-positive participants, a significantly higher percentage of HIV-negative
participants incorrectly stated that HIV is transmitted through saliva and that oil-based lubricants do not make
condoms more likely to break (p<0.05). Logistic regression analysis showed that those with history of CSA (Odds
Ratio [OR]=8.4, 95% Confidence Interval [CI]=1.4-50.9) and alcohol abuse (OR=5.6, 95% CI=1.2-26.8) were more
likely to be depressed relative to the other groups.
Conclusion: No difference was found in depression prevalence between HIV-positive and HIV-negative
participants. Depression was significantly associated with CSA and alcohol abuse, indicating the need for increased
depression screening among individuals with these risk factors. There was decreased knowledge about HIV
transmission among HIV-negative participants, showing that increased HIV-related education is needed in this
population.
16