TUESDAY, 28 AUGUST 2012 – MORNING SESSIONS 08:30–10:00 | Munich - Central Village 2012 UPDATE OF THE ESC GUIDELINES ON THE MANAGEMENT OF ATRIAL FIBRILLATION The Committee for Practice Guidelines Symposium Chairperson(s): A.J. Camm (London, GB); D. Atar (Oslo, NO) 08:30 08:45 09:05 09:25 09:40 Risk prediction for stroke in atrial fibrillation. – R. De Caterina (Chieti, IT) Selection of antithrombotic therapy for atrial fibrillation. Integration of stroke and bleeding risk. – G.Y.H. Lip (Birmingham, GB) Antiarrhythmic drug therapy for prevention of atrial fibrillation recurrences. – S.H. Hohnloser (Frankfurt, DE) Cardioversion of atrial fibrillation. – I. Savelieva (London, GB) Interventional techniques for the management of atrial fibrillation. – P. Kirchhof (Birmingham, GB) 3754 3755 3756 3757 3758 08:30–10:00 | Tbilisi - Central Village THE CARDIOVASCULAR MEDICINE IN EUROPE TODAY: THE ESC REGISTRIES Symposium Chairperson(s): M. Komajda (Paris, FR); L. Tavazzi (Cotignola, IT) 08:30 08:37 08:47 09:02 09:12 09:22 09:37 09:42 Ongoing and forthcoming registries. Update. – L. Tavazzi (Cotignola, IT) Chronic Ischaemic Cardiovascular Disease Pilot Registry. – R. Ferrari (Ferrara, IT) EUROASPIRE IV. – G. De Backer (St. Martens Latem, BE) Cardiomyopathy Registry. – P.M. Elliott (London, GB) Peripartum Cardiomyopathy Registry. – K. Sliwa-Hahnle (Cape Town, ZA) Atrial Fibrillation Pilot Registry. – G.Y.H. Lip (Birmingham, GB) Prospective considerations. – M. Komajda (Paris, FR) Discussion. 3759 3760 3761 3762 3763 3764 3765 08:30–10:00 | Tirana - Central Village THE CURRENT SITUATION AND EXPERIENCE OF ST-ELEVATION MYOCARDIAL INFARCTION REPERFUSION THERAPY IN CHINA AND EUROPE ESC and the Chinese Society of Cardiology Symposium Chairperson(s): F.J. Pinto (Lisbon, PT); D. Hu (Beijing, CN) 08:52 09:15 09:37 Treatment of ST-elevation myocardial infarction in Europe. – K. Huber (Vienna, AT) Chest pain units in Europe. – T.F. Munzel (Mainz, DE) The treatment of ST-elevation myocardial infarction in China: where are we? – Y.H. Sun (Peking, CN) The experience of chest pain centres: in China, what have we got? – D.C. Xiang (Guangzhou, CN) 3766 3767 3768 3769 TUESDAY – MORNING 08:30 08:30–10:00 | Beirut - Village 1 INTERFERING WITH THE IMMUNE SYSTEM IN ATHEROSCLEROSIS: THERAPIES OF THE FUTURE? ESC and the European Atherosclerosis Society Symposium Chairperson(s): P. Libby (Boston, US); L. Tokgozoglu (Ankara, TR) 08:30 08:52 09:15 09:37 The immune system and atherosclerosis - a complex relationship. – C.J. Binder (Vienna, AT) The atherosclerotic lesion, a meeting place for inflammatory cells. – G.K. Hansson (Stockholm, SE) B-cell modification in atherogenesis. – H. Ait-Oufella (Paris, FR) Immunisation for atherosclerosis: promise and reality. – J. Nilsson (Malmo, SE) 3770 3771 3772 3773 223 TUESDAY, 28 AUGUST 2012 – MORNING SESSIONS 08:30–10:00 | Riga - Village 1 DESTROYING AND RESTORING CARDIOMYOCYTE ARCHITECTURE Symposium Chairperson(s): S.E. Lehnart (Göttingen, DE); K. Dibb (Manchester, GB) 08:30 08:52 09:15 09:37 Sarcolemmal disorganisation leads to dyssynchrony of calcium release. – K.R. Sipido (Leuven, BE) Remodelling of the cardiac sarcoplasmic reticulum and t-tubules following conditional SERCA2 knockout. – F. Swift (Oslo, NO) T-tubule remodelling during transition from hypertrophy to heart failure. – M.E. Anderson (Iowa, US) Reversing the loss of t-tubule structure by mechanical unloading. – C. Terracciano (Harefield, GB) 3774 3775 3776 3777 08:30–10:00 | Tripoli - Village 1 MITOCHONDRIAL DYNAMICS IN CARDIOVASCULAR HEALTH AND DISEASE ESC and the International Society for Heart Research Symposium Chairperson(s): D. Garcia-Dorado Garcia (Barcelona, ES); P. Ferdinandy (Szeged, HU) 08:30 08:52 09:15 09:37 Mitochondrial dynamics in ischaemia and reperfusion. – D.J. Hausenloy (London, GB) Modulation of the oxidative and phosphorylation post-translational modifications and their impact on mitochondria-myofilament. – V. Kooij (Baltimore, US) Mitochondrial dynamics and autophagy. – L. Scorrano (Geneva, CH) Mitofusins and cardiovascular health and disease. – C. Maack (Homburg/Saar, DE) 3778 3779 3780 3781 08:30–10:00 | Algiers - Village 2 NOVEL ASPECTS ON PROGNOSIS IN HYPERTENSION Abstract Session Chairperson(s): A. Coca (Barcelona, ES); A. Persu (Brussels, BE) 08:30 08:45 09:00 09:15 09:30 09:45 Relation between blood pressure lowering therapy and cardiovascular events and mortality in hypertensive patients with coronary artery disease and type 2 diabetes: the HIJ-CREATE sub-study. – H. Ogawa, R. Koyanagi, E. Kawada-Watanabe, J. Yamaguchi, A. Takagi, N. Hagiwara (Tokyo, JP) The effect of visit-to-visit variability in blood pressure on stroke and coronary events in the TNT, IDEAL and CARDS trials. – P.C. Deedwania, D.A. Demicco, A. Breazna, C.C. Wun, T. Pedersen, H.M. Colhoun, A. Neil, G. Hitman (Fresno and New York, US; Oslo, NO; Dundee, Oxford and London, GB) Low attenuation coronary plaque on multidetector computed tomography predicts three-year acute coronary syndrome events in patients with hypertension. – K. Nakanishi, S. Fukuda, K. Shimada, S. Ehara, H. Inanami, K. Matsumoto, H. Taguchi, T. Muro, J. Yoshikawa, M. Yoshiyama (Osaka, Higashiosaka and Nishinomiya, JP) Pulse wave velocity as independent predictor of stroke in patients with essential hypertension: data from a Greek 6-year-follow-up study. – K. Dimitriadis, C. Tsioufis, I. Tatsis, G. Chlapoutakis, L. Lioni, V. Tzamou, A. Kasiakogias, C. Thomopoulos, D. Tousoulis, C. Stefanadis (Athens, GR) Prediction of cardiovascular events and all-cause mortality with brachial-ankle pulse wave velocity: a systematic review and meta-analysis of cohort studies. – D. Terentes-Printzios, C. Vlachopoulos, K. Aznaouridis, N. Ioakeimidis, C. Stefanadis (Athens, GR) Influence of family history of hypertension and hypertension per se on overall and cardiovascular mortality in the Seven Countries Studies: the 40 years’ follow up results. – B. Parapid, V. Vukcevic, B. Obrenovic-Kircanski, D.V. Simic, N.M. Milic, V. Stojanov, B. Beleslin, I. Nedeljkovic, O.M.S. Nedeljkovic-Arsenovic, M.C. Ostojic (Belgrade, RS) 3782 3783 3784 3785 3786 3787 08:30–10:00 | Berlin - Village 2 OFF TARGET – CHEMOTHERAPEUTICS AND THE CARDIOVASCULAR SYSTEM ESC and the American Heart Association Symposium Chairperson(s): D. Cardinale (Milan, IT); D. Arnett (Birmingham, US) 08:30 08:52 09:15 09:37 224 Anthracycline-induced cardiomyopathy - novel mechanistic insight. – M. Jessup (Philadelphia, US) Imaging techniques for early diagnosis of cardiotoxicity. – T. Lopez Fernandez (Majadahonda, ES) Tyrosine kinase inhibitors - from cancer drugs to study drugs into the cardiovascular system. – T.L. Force (Philadelphia, US) Cardiotoxicity. Beyond antracicline. – R. Giuliani (Rome, IT) 3788 3789 3790 3791 TUESDAY, 28 AUGUST 2012 – MORNING SESSIONS 08:30–10:00 | Zagreb - Village 2 CENTRAL BLOOD PRESSURE AND PERIPHERAL VESSELS IN HYPERTENSION Abstract Session Chairperson(s): C. Vlachopoulos (Athens, GR); S. Laurent (Paris, FR) 08:30 08:45 09:00 09:15 09:30 09:45 Validation and clinical application of systolic and diastolic central pressures derived from pulse wave analysis. – D. Kotecha, H. Krum, G. New, D. Eccleston, P. Collins, M. Flather, J. Pepper (London and Norwich, GB; Melbourne, AU) Central blood pressure: a possible powerful predictor of the development of hypertension. – H. Tomiyama, M. Odaira, M. Yoshida, K. Shiina, C. Matsumoto, A. Yamashina (Tokyo, JP) N- terminal fragment of brain natriuretic peptide predicts vascular health and subclinical atherosclerosis: results from MEHLP study. – L.E. Pastormerlo, S. Maffei, V. Chubuchny, A.M. Mazzone, C. Susini, C. Passino, D. Chiappino, M. Emdin, A. Clerico (Pisa, IT) Selective serotonin reuptake inhibitors exert a negative effect on peripheral wave reflections. – V. Katsi, G. Souretis, I. Vlasseros, D. Vrachatis, D. Tousoulis, C. Stefanadis, I. Kallikazaros (Athens, GR) Renin-angiotensin aldosterone system gene polymorphisms and their association with vascular impairment in patients with essential hypertension. – E. Androulakis, D. Tousoulis, E. Chatzistamatiou, N. Papageorgiou, A. Miliou, C. Vlachopoulos, G. Siasos, G. Moustakas, I. Kallikazaros, C. Stefanadis (Athens, GR) Insulin resistance is associated with increased large artery stiffness in normotensive healthy adults. – J.E. Ochoa, J.K. Balparda, M.M. Correa, A.M. Valencia, M. Alvarez, J.G. Mcewen, G. Bilo, P. Salvi, D. Aristizabal, G. Parati (Milan, IT; Medellin, CO) 3792 3793 3794 3795 3796 3797 08:30–10:00 | Athens - Village 3 MODERN CARDIAC REHABILITATION MOVING BEYOND FUNDAMENTALS Abstract Session Chairperson(s): S. Gielen (Halle, DE); J.P. Ribeiro (Porto Alegre, BR) 08:45 09:00 09:15 09:30 09:45 Multidisciplinary cardiac rehabilitation and survival in The Netherlands. – H. De Vries, M. Engen-Verheul, H.M.C. Kemps, R. Kraaijenhagen, N. Peek (Amsterdam and Veldhoven, NL) Cardiovascular rehabilitation after a first acute coronary syndrome and the risk of recurrence and death in patients from the French MONICA registries. – P.L. Vervueren, V. Bongard, D. Arveiler, J. Dallongeville, J.B. Ruidavets, A. Wagner, P. Amouyel, A. Bingham, M. Elbaz, J. Ferrieres (Toulouse, Strasbourg, Lille and Paris, FR) Phase II comprehensive cardiac rehabilitation prevents readmission for heart failure in patients with chronic heart failure and high brain natriuretic peptide levels. – K. Kamiya, A. Mezzani, K. Hotta, M. Tabata, C. Noda, K. Ohori, T. Inomata, M. Yamaoka-Tojo, A. Matsunaga, T. Masuda (Sagamihara, JP; Veruno, IT) Compliance to a cardiac rehabilitation program: what benefits and prognosis impact? – I. Rangel, A. Rocha, C. Sousa, A. Sousa, A.S. Correia, M. Paiva, F. Melao, V. Araujo, F. Parada-Pereira, M.J. Maciel (Porto, PT) The effects of respiratory muscle trainings on systemic inflammation and fibrosis process in patients with heart failure. – E.A. Kolesnikova, G.P. Arutyunov, A.K. Rylova, N.V. Rylova, V.I. Lobzeva (Moscow, RU) Beneficial effects of rehabilitation in comparison with resychronization therapy in patients with NYHA III heart failure. – T. Chwyczko, E. Smolis-Bak, R. Dabrowski, M. Sterlinski, A. Maciag, A. Borowiec, I. Kowalik, M. Pytkowski, H. Szwed (Warsaw, PL) 3798 3799 3800 3801 3802 3803 TUESDAY – MORNING 08:30 225 TUESDAY, 28 AUGUST 2012 – MORNING SESSIONS 08:30–10:00 | Nicosia - Village 3 NOVEL APPROACHES TO EXERCISE TRAINING Abstract Session Chairperson(s): M. Halle (Munich, DE); M. Mendes (Carnaxide, PT) 08:30 08:45 09:00 09:15 09:30 09:45 Biventricular filling impairment limits cardiac performance during exercise in healthy subjects. – G. Claessen, A. La Gerche, A. Van De Bruaene, M. Gewillig, S. Dymarkowski, P. Claus, H. Heidbuchel (Leuven, BE) Evaluation of a newly designed shirt-based ECG and breathing sensor for home based training as part of cardiac rehabilitation for coronary artery disease. – E. Skobel, C. Knackstedt, A. Martinez Romero, B. Scheibe-Schmidt, P. Schauerte (Aachen, DE; Maastricht, NL; Valencia, ES) Music as additional therapeutic option to exercise training for endothelial dysfunction in patients with stable coronary artery disease. – M. Deljanin Ilic, S. Ilic, G. Kocic, R. Pavlovic, V. Stoickov, V. Ilic (Niska Banja and Nis, RS) Exercise capacity in patients with coronary artery disease: what is beyond global left ventricular systolic function? – A.S. Correia, A. Goncalves, A. Rocha, S. Costa, F. Guilherme, M. Paiva, A. Sousa, V. Araujo, F.P. Pereira, M.J. Maciel (Porto, PT) Passive whole-body exercise training with periodic acceleration improves endothelial function in sedentary subjects. – T. Matsumoto, M. Fujita, H. Hayashi, I. Nakae, M. Horie (Kashiwara, Kyoto and Otsu, JP) Exercise echocardiography - effects of endurance training and ageing. – R.H. Olsen, T. Monk-Hansen, C. Couppe, U.R. Mikkelsen, A. Karlsen, C.H. Dall, P. Magnusson, E. Prescott (Copenhagen, DK) 3804 3805 3806 3807 3808 3809 08:30–10:00 | Yerevan - Village 3 EAT, DRINK AND BE MERRY? Symposium Chairperson(s): C.S. Jennings (London, GB); E. Bruckert (Paris, FR) 08:30 08:52 09:15 09:37 Dark chocolate and cardiovascular health. – S. Desch (Leipzig, DE) Red wine: ready for prescription? – E.J.G. Sijbrands (Rotterdam, NL) Laughter and other positive emotions on the heart. – S.S. Pedersen (Tilburg, NL) Eat well and live long? – F. Sofi (Florence, IT) 3810 3811 3812 3813 08:30–10:00 | Budapest - Village 4 OPTIMISATION OF MYOCARDIAL REPERFUSION IN STEMI Abstract Session Chairperson(s): E.M. Antman (Boston, US); J.-P. Collet (Paris, FR) 08:30 08:45 09:00 09:15 09:30 09:45 226 Soluble TNF receptors are associated with infarct size and ventricular dysfunction in ST-elevation myocardial infarction. – A. Szymanowski, L. Nilsson, E. Swahn, L. Jonasson (Linköping, SE) Hemostatic and fibrinolytic profile in patients with ST-segment elevation myocardial infarction resistant to fibrinolysis. – M. Mutuberria, A. Sambola, J. Francisco Pascual, J. Figueras, B. Garcia Del Blanco, G. Marti, M. Ruiz-Meana, I. Otaegui, J. Barrabes, D. Garcia-Dorado (Barcelona, ES) Long term effect of minimising pain-to-balloon time on mortality in ST- elevation infarction. The ANIN Myocardial Infarction Registry. – M. Polanska-Skrzypczyk, M. Karcz, P. Bekta, C. Kepka, J. Przyluski, M. Kruk, E. Ksiezycka, A. Ciszewski, A. Witkowski, W. Ruzyllo (Warsaw, PL) Left bundle branch block and suspected myocardial infarction: an under-treated patient group? – T. Kellerth, V. Liakopoulos, K. Christensen (Örebro, SE) Primary percutaneous coronary intervention with and without thrombus aspiration. – M. Tariq Farman, S. Tahir, S. Nadeem Hasan Rizvi, K. Naveedullah, S. Jawaid Akbar (Karachi and Larkana, PK) Drug eluting stents are associated with lower MACE rates compared to bare metal stents in small coronary arteries treated by primary PCI for STEMI. – D. Bromage, K.S. Rathod, D.A. Jones, R. Sen, J. Patel, A. Jain, C. Knight, A. Mathur, A. Wragg (London, GB) 3814 3815 3816 3817 3818 3819 TUESDAY, 28 AUGUST 2012 – MORNING SESSIONS 08:30–10:00 | Prague - Village 4 FROM BENCH TO PRACTICE: REMOTE ISCHAEMIC CONDITIONING FOR CARDIO- AND NEUROPROTECTION Symposium Chairperson(s): M. Ovize (Lyon, FR); R. Schulz (Giessen, DE) 08:30 08:52 09:15 09:37 Update on mechanisms of cardio- and neuroprotection. – A. Redington (Toronto, CA) Effects of conditioning on tissue perfusion. – R. Kharbandar (Oxford, GB) Influence of ageing, risk factors and comorbidities. – G. Niccoli (Rome, IT) Remote conditioning in myocardial infarction and stroke. – H.E. Botker (Aarhus, DK) 3820 3821 3822 3823 08:30–10:00 | Vienna - Village 4 FROM BENCH TO PRACTICE: ANAEMIA IN ACUTE CORONARY SYNDROMES Clinical Seminar Chairperson(s): H. Bueno (Madrid, ES); E. Swahn (Linköping, SE) 08:30 08:52 09:15 09:37 Red blood cells and vascular function. – M. Kelm (Düsseldorf, DE) Anaemia and prognosis in acute coronary syndromes. – J.-P. Bassand (Besançon, FR) Bleeding complications: different definitions and treatment. – C.J.M. Vrints (Edegem, BE) Management of pre-existing anaemia. – S.D. Anker (Berlin, DE) 3824 3825 3826 3827 08:30–10:00 | Baku - Village 5 HEART FAILURE IN THE ELDERLY: A DIFFERENT SYNDROME? Clinical Seminar Chairperson(s): A.W. Hoes (Utrecht, NL); T.A. McDonagh (London, GB) 08:30 08:52 09:15 09:37 Causes of death and hospitalisation. – A.P. Maggioni (Florence, IT) Diagnostic challenges. – S.J. Goodlin (Portland, US) Biomarkers in the elderly: useful or meaningless? – D.J. van Veldhuisen (Groningen, NL) Therapeutic peculiarities: are there any? – M.R. Cowie (London, GB) 3828 3829 3830 3831 08:30–10:00 | Copenhagen - Village 5 MYOCARDIAL REGENERATION: WHAT CELL SOURCES TO USE? Clinical Seminar Chairperson(s): S. Janssens (Leuven, BE); C.A. Beltrami (Udine, IT) 08:52 09:15 09:37 Embryonic stem cells? – W.-H. Zimmermann (Göttingen, DE) Inducible progenitor stem cells? – W. Wojakowski (Katowice, PL) Adult heart cells? – P.A.F.M. Doevendans (Utrecht, NL) Clinical perspective. – A.M. Zeiher (Frankfurt, DE) 3832 3833 3834 TUESDAY – MORNING 08:30 3835 227 TUESDAY, 28 AUGUST 2012 – MORNING SESSIONS 08:30–10:00 | Reykjavik - Village 5 IMPORTANCE OF CO-MORBIDITIES IN HEART FAILURE Abstract Session Chairperson(s): P. Van Der Meer (Groningen, NL); G.M.C. Rosano (Rome, IT) 08:30 08:45 09:00 09:15 09:30 09:45 Prognostic impact of the timing/degree of Acute Kidney Injury for Acute Heart Failure: an evaluation of the RIFLE Criteria. – A. Shirakabe, N. Hata, N. Kobayashi, T. Shinada, K. Tomita, M. Tsurumi, M. Matsushita, T. Shimura, K. Asai, K. Mizuno (Chiba and Tokyo, JP) Prevalence and predictors of sleep-disordered breathing in patients with stable chronic heart failure: the SchlaHF-Registry. – H. Woehrle, M. Arzt, O. Oldenburg, E. Erdmann, H. Teschler, A. Graml, K. Wegscheider (Blaubeuren, Regensburg, Bad Oeynhausen, Cologne, Essen, Martinsried and Hamburg, DE) Incidence of impaired pulmonary function in men with systolic heart failure and its clinical significance. – B. Krakowiak, M. Olesinska, B. Paleczny, K. Ludwikowska, W. Banasiak, P. Ponikowski, E.A. Jankowska (Wroclaw, PL) Are functional and absolute iron deficiencies equally detrimental in heart failure? – M. De Antonio, J. Lupon, J. Comin, A. Galan, B. Gonzalez, L. Cano, R. Cabanes, A. Urrutia, E. Zamora, A. Bayes-Genis (Badalona and Barcelona, ES) Glycometabolic imbalance is a main determinant of neurohormonal activation and cardiac mortality in mild systolic heart failure. – L.E. Pastormerlo, C. Mammini, A. Gabutti, R. Poletti, G. Mirizzi, S. Chiappino, C. Passino, M. Emdin (Pisa, IT) Prognostic value of atrial fibrillation pattern in heart failure. – S. Taillandier, L. Fauchier, B. Lallemand, N. Clementy, A. Bernard, B. Pierre, E. Simeon, S. Taillandier, D. Babuty (Tours, FR) 3836 3837 3838 3839 3840 3841 08:30–10:00 | Cairo - Village 6 MANAGEMENT OF ACUTE AORTIC SYNDROMES Clinical Seminar Chairperson(s): M. Czerny (Berne, CH); V. Riambau (Barcelona, ES) 08:30 08:52 09:15 09:37 Natural history. – G. Rocchi (Bologna, IT) Predictors of complications. – A. Evangelista Masip (Barcelona, ES) Indications for endovascular treatment. – C.A. Nienaber (Rostock, DE) Indications for surgical or hybrid intervention. – M. Grabenwoeger (Vienna, AT) 3842 3843 3844 3845 08:30–10:00 | Dublin - Village 6 SURGERY FOR VALVULAR HEART DISEASE: PREDICTORS OF OUTCOME Abstract Session Chairperson(s): D. Adams (New York, US); M. De Bonis (Milan, IT) 08:30 08:45 09:00 09:15 09:30 09:45 228 Do mitral valve replacement versus repair in patients with severe ischemic mitral regurgitation affect survival? – V. Shumaviec, Y. Ostrovski, A. Shket, A. Janushko, A. Lysjonok, O. Jdanovich, A. Beresneva (Minsk, BY) Different surgical techniques of mitral valve repair for Ischemic mitral regurgitation: predictors of efficacy. – V. Shumaviec, Y. Ostrovski, N. Moroz-Vodolajskaja, S. Kurganovich, N. Semenova, I. Grinchuk, A. Shket, A. Janushko (Minsk, BY) Comparison of risk scores for predicting early mortality after Aortic Valve Replacement for aortic stenosis. – K. Kuwaki, A. Amano, H. Inaba, T. Yamamoto, T. Morita, S. Dohi, T. Matsumura, R. Tsuruta, A. Oishi, Y. Sato (Tokyo, JP) Aortic valve replacement: relationship between aortic stenosis severity and perioperative mortality risk scores. – M. Floria, I.M. Mariciuc Bucur, L. Gabriel, M. Gerard, M. Buche, P. Eucher, Y. Louagie, J. Jamart, B. Marchandise, E. Schroeder (Yvoir, BE; Iasi, RO) Predictors of persistent severe diastolic dysfunction after aortic valve replacement in aortic stenosis compared with aortic regurgitation. – L. Iliuta (Bucharest, RO) Need for permanent pacemaker implantation after corevalve, sapien and surgical aortic valve replacement: incidence, time course and predictive factors. – I. Franzoni, A. Latib, A. Chieffo, G.L. Buchanan, M. Slavich, F. Maisano, M. Montorfano, A. Radinovic, O. Alfieri, A. Colombo (Milan, IT) 3846 3847 3848 3849 3850 3851 TUESDAY, 28 AUGUST 2012 – MORNING SESSIONS 08:30–10:00 | Minsk - Village 6 TRANSRADIAL CORONARY INTERVENTIONS Clinical Seminar Chairperson(s): C. Trani (Rome, IT); R.-L. Gao (Beijing, CN) 08:30 08:52 09:15 09:37 Left main and bifurcations lesions. – G. Stankovic (Belgrade, RS) Chronic total occlusion: when to go transradial? – Y. Ikari (Kanagawa, JP) Ad-hoc and outpatient angioplasty. – F. Kiemeney (Amsterdam, NL) Complications management. – V. Velchev (Sofia, BG) 3852 3853 3854 3855 08:30–10:00 | Brussels - Village 7 SYNCOPE MANAGEMENT: FILLING GAPS BETWEEN GUIDELINES AND PRACTICE Symposium Chairperson(s): E. Kanoupakis (Heraklion, GR); J. Gajek (Wroclaw, PL) 08:30 08:52 09:15 09:37 The standardised management. – A. Moya I Mitjans (Barcelona, ES) Syncope clinic and interactive decison-making softwares. – R.A. Kenny (Dublin, IE) The role of continuous ECG monitoring. – M. Brignole (Lavagna, IT) The role of pacing: how to identify responders. – R. Sutton (Monte Carlo, MC) 3856 3857 3858 3859 08:30–10:00 | Tallinn - Village 7 E-HEALTH AND REMOTE MONITORING USING IMPLANTABLE DEVICES Symposium Chairperson(s): E. Simantirakis (Heraklion, GR); G. Boriani (Bologna, IT) 08:30 08:52 09:15 09:37 Continuous ECG telemonitoring with implantable devices: the expected clinical benefits. – C.W. Israel (Bielefeld, DE) Pacemaker and implantable cardioverter-defibrillator follow-up. Current developments. – R. Hatala (Bratislava, SK) Data bulk, analysis and coherent problems. – L. Van Erven (Bussum, NL) The cost, the taxpayers and the care protagonists. – P.E. Vardas (Heraklion, GR) 3860 3861 3862 3863 08:30–10:00 | Tel Aviv - Village 7 OUTCOMES AND COMPLICATIONS OF CATHETER ABLATION FOR ATRIAL FIBRILLATION Abstract Session Chairperson(s): H. Puererfellner (Linz, AT); S. Ernst (London, GB) 08:45 09:00 09:15 09:30 09:45 Five years follow up of patients undergoing catheter ablation of persistent atrial fibrillation using the stepwise approach: BLOC-AF study. – D. Scherr, S. Miyazaki, V. Aurillac-Lavignolle, Y. Komatsu, P. Pascale, H. Cochet, F. Sacher, M. Hocini, P. Jais, M. Haissaguerre (Bordeaux, FR) Additional ablation of complex fractionated atrial electrograms in long-lasting persistent atrial fibrillation. Does it change the ablation success? Results from the German ablation registry. – M. Schloesser, R. Becker, J. Tebbenjohanns, J. Brachmann, D. Andresen, B.D. Gonska, G. Richardt, M. Horack, J. Senges, C. Stellbrink (Bielefeld, Heidelberg, Hildesheim, Coburg, Berlin, Karlsruhe, Segeberg and Ludwigshafen, DE) Rhythm control in elderly patients with persistent atrial fibrillation: a randomized comparison of catheter ablation versus antiarrhythmic drugs. – A. Blandino, E. Toso, M. Anselmino, D. Sardi, A. Battaglia, M. Scaglione, F. Gaita (Turin and Asti, IT) Incidence and management of potentially fatal peri-procedural tamponade in patients undergoing pulmonary vein isolation for atrial fibrillation. – C.I. Park, A. Jadidi, R. Weber, H. Lehrmann, J. Schiebeling, J. Allgeier, C. Herrera Siklody, M. Haissaguerre, P. Jais, T. Arentz (Bad Krozingen, DE; Bordeaux-Pessac, FR) Asymptomatic cerebral lesions in pulmonary vein isolation under therapeutic anticoagulation. – M. Martinek, E. Sigmund, C.H. Lemes, M. Derndorfer, J. Aichinger, S. Winter, H.J. Nesser, H. Puererfellner (Linz, AT) Long-term results of transcatheter atrial fibrillation ablation in patients with impaired left ventricular systolic function. – M. Anselmino, S. Grossi, M. Scaglione, D. Castagno, F. Bianchi, G. Senatore, M. Matta, F. Ferraris, Y. Cristoforetti, F. Gaita (Turin, Asti and Ciriè, IT) 3864 3865 TUESDAY – MORNING 08:30 3866 3867 3868 3869 229 TUESDAY, 28 AUGUST 2012 – MORNING SESSIONS 08:30–10:00 | Helsinki - Village 8 DIAGNOSIS AND MANAGEMENT OF CARDIAC TAMPONADE Clinical Seminar Chairperson(s): Y. Adler (Rannana, IL); B.A. Popescu (Bucharest, RO) 08:30 08:52 09:15 09:37 Clinical presentation and differential diagnosis. – M. Imazio (Turin, IT) Echocardiography in diagnosis and management. – L. Badano (Padua, IT) State of the art of percutaneous procedures for the management. – B. Maisch (Marburg, DE) Surgical treatment. – P. Seferovic (Belgrade, RS) 3870 3871 3872 3873 08:30–10:00 | Rome - Village 8 TRANSCATHETER AORTIC VALVE IMPLANTATION (TAVI) IN CURRENT AND FUTURE CLINICAL PRACTICE Abstract Session Chairperson(s): A.H.P. Linke (Leipzig, DE); C. Lotan (Jerusalem, IL) 08:30 08:45 09:00 09:15 09:30 09:45 Early experience with the JenaValve transapical aortic valve implantation system. – M. Ferrari, H.R. Figulla, M. Breuer, H. Treede, S. Baldus, A. Rastan, S. Ensminger, M. Arnold, T. Walther, F.W. Mohr (Jena, Hamburg, Rotenburg, Bad Oeynhausen, Erlangen, Bad Nauheim and Leipzig, DE) The impact of pulmonary hypertension on outcome in TAVI patients: a two-centre experience. – M. Vasa-Nicotera, J.M. Sinning, D. Chin, C. Hammerstingl, A. Ghanem, R. Schueler, E. Grube, J. Kovac, G. Nickenig, N. Werner (Bonn, DE; Leicester, GB) Is mitral regurgitation reversible in patients undergoing transcatheter aortic valve implantation? – D. Rosenmann, Y. Almagor, M. Klutstein, J. Balkin, R. Farkash, D. Tzivoni (Jerusalem, IL) Perivalvular aortic regurgitation: a major predictor of 1-year mortality after a successful TAVI procedure - insights from the FRANCE2 registry. – E. Van Belle, N. Dumonteil, F. Juthier, B. Iung, H. Eltchaninoff, D. Carrie, M. Laskar, M. Gilard, A. Prat, E. Teiger (Lille, Toulouse, Paris, Rouen, Limoges, Brest and Créteil, FR) The impact of transcatheter aortic valve implantation on quality of life. Results from the German transcatheter aortic valve interventions registry. – J. Biermann, M. Horack, P. Kahlert, T. Konorza, B. Plicht, J. Wasem, R. Zahn, J. Senges, R. Erbel, T. Neumann (Essen and Ludwigshafen, DE) The impact of transcatheter aortic valve implantation on resource use. Results from the German transcatheter aortic valve interventions registry. – J. Biermann, M. Horack, P. Kahlert, T. Konorza, B. Plicht, J. Wasem, R. Zahn, J. Senges, R. Erbel, T. Neumann (Essen and Ludwigshafen, DE) 3874 3875 3876 3877 3878 3879 08:30–10:00 | Sarajevo - Village 8 HOW TO DEAL WITH HIGH-RISK PREGNANCY Symposium Chairperson(s): J.W. Roos-Hesselink (Rotterdam, NL); G. Simonneau (Clamart, FR) 08:30 08:52 09:15 09:37 Risk stratification in congenital heart disease. – F. Walker (London, GB) Risk stratification of patients with pulmonary hypertension. – To be announced Management of pulmonary arterial hypertension. – M. Gomberg-Maitland (Chicago, US) Severe aortic stenosis. – P. Tornos Mas (Barcelona, ES) 3880 3881 3882 3883 08:30–10:00 | Paris - Village 9 HIGHLIGHTS OF EUROCMR 2012 Symposium Chairperson(s): H. Mahrholdt (Stuttgart, DE); H. Frank (Tulln, AT) 08:30 08:52 09:15 09:37 230 Insights in Tako-Tsubo syndrome. – M.G. Friedrich (Montreal, CA) Clinical value in acute coronary syndrome. – H. Thiele (Leipzig, DE) Ongoing imaging trials that may change clinical practice. – E. Nagel (London, GB) Cardiovascular magnetic resonance to guide cardiac resynchronisation therapy. – J. Schulz-Menger (Berlin, DE) 3884 3885 3886 3887 TUESDAY, 28 AUGUST 2012 – MORNING SESSIONS 08:30–10:00 | Pristina - Village 9 NEW INSIGHTS IN MYOCARDIAL INFARCTION BY MULTIMODALITY IMAGING Abstract Session Chairperson(s): A.N. Neskovic (Belgrade, RS); A. Hagendorff (Leipzig, DE) 08:30 08:45 09:00 09:15 09:30 09:45 Effect of manual thrombus aspiration during primary percutaneous coronary intervention on infarct size: a delayed enhancement MDCT study. – D.S. Sim, Y.K. Ahn, Y.H. Kim, Y.J. Hong, H.W. Park, J.H. Kim, M.H. Jeong, J.G. Cho, J.C. Park, J.C. Kang (Gwangju, KR) In vivo non invasive quantitative assessment of passive diastolic stiffness of infarcted myocardium using shear wave imaging. – M. Pernot, W.N. Lee, M. Couade, P. Mateo, B. Crozatier, A. Bel, M. Tanter, E. Messas (Paris and Chatenay-Malabry, FR) Myocardial fibrosis and fat may be substrates of critical ventricular arrhythmia. comparison of 320 slice CT images in subjects who had ventricular fibrillation with sustained ventricular tachycardia. – K. Ozawa, N. Funabashi, H. Takaoka, A. Kataoka, M. Uehara, Y. Kobayashi (Chiba, JP) Association between left ventricular longitudinal function and neurohormonal activation after acute myocardial infarction. A two dimensional speckle tracking study. – M.K. Ersboll, N. Valeur, U.M. Mogensen, M.J. Andersen, R.G. Greibe, J.E. Moller, C. Hassager, P. Sogaard, L. Kober (Copenhagen, DK) Two-dimensional longitudinal strain is more accurate than three-dimensional longitudinal strain to identify infarcted LV segments in STEMI patients. – D. Muraru, L.P. Badano, D. Ermacora, R. Bellu, M. De Lazzari, M.P. Marra, L. Dal Bianco, D. Peluso, F. Boccalini, S. Iliceto (Padua, IT) Necrosis and ischemia for risk stratification in patients with known or suspected ischemic cardiomyophaty. Study with stress cardiac magnetic resonance. – C. Bonanad, J.V. Monmeneu, M.P. Lopez-Lereu, J. Sanchis, J. Nunez, M.J. Bosch, C. Gomez, F. Chaustre, F.J. Chorro, V. Bodi Peris (Valencia, ES) 3888 3889 3890 3891 3892 3893 08:30–10:00 | Sofia - Village 9 STRESS CARDIOVASCULAR MAGNETIC RESONANCE (CMR) IN CORONARY HEART DISEASE Symposium Chairperson(s): F.E. Rademakers (Leuven, BE); S. Plein (Leeds, GB) 08:30 08:52 09:15 09:37 Pathophysiological considerations on stress CMR. – A.M.G. Almeida (Lisbon, PT) Long-term prognostic value of dobutamine stress CMR. – S. Kelle (Berlin, DE) Prognostic implications of dipyridamole CMR: a prospective multicentre registry. – O. Husser (Regensburg, DE) CMR imaging to guide complex revascularisation in stable coronary artery disease. – J. Schwitter (Lausanne, CH) 3894 3895 3896 3897 08:30–10:00 | London - Village 10 THE CARDIAC RESYNCHRONISATION THERAPY NON RESPONDER. LIVE FROM LEIPZIG. Focus Imaging Intervention Chairperson(s): G. Hindricks (Leipzig, DE); A. Auricchio (Lugano, CH) What is a non responder: definitions and clinicalreality. Management of non-response: device programming. TUESDAY – MORNING Prevention of non-response during index implantation. Management of non-response: left-ventricular lead optimization. Live case: cardiovascular resynchronisation therapy optimization for clinical non response. – G. Hindricks (Leipzig, DE) Panel. – J.C. Daubert (Rennes, FR), G. Hindricks (Leipzig, DE), C. Piorkowski (Leipzig, DE), F. Ruschitzka (Zurich, CH), J. Singh (Boston, US) 3898 3899 08:30–10:00 | The Hague - Village 10 PREVENTION IN THE MULTI-RISK PATIENT: HOW TO PUT GUIDELINES INTO CLINICAL REALITY Focus Cardiology Practice Chairperson(s): V. Conraads (Edegem, BE); M.C. Deaton (Manchester, GB) Primary prevention. Not a patient yet: what’s the point? Secondary prevention and physical activity: never too late? Changing lifestyle: easier said than done. Panel. – M.C. Deaton (Manchester, GB), F.D.R. Hobbs (Oxford, GB), J. Niebauer (Salzburg, AT) 3900 231 TUESDAY, 28 AUGUST 2012 – MORNING SESSIONS 08:30–10:00 | Case Corner - Village 10 CASE-BASED LEARNING FROM THE ESC CARDIOLOGISTS OF TOMORROW: WHAT CAN DEATH TEACH US? Clinical Cases Chairperson(s): R.C. Vidal Perez (Santiago de Compostela, ES); U. Sechtem (Stuttgart, DE) 08:30 Introduction by the Chairpersons. 08:33 Sinus arrest as a mechanism of sudden cardiac death in a heart transplant patient for more than five years. – M.-T. Liao (Tapei, TW) ST-segment Elevation Myocardial Infarction (STEMI) by air embolism complicating an Atriooesophageal Fistula caused by transcatheter ablation of atrial fibrillation. – F. Seguro (Toulouse, FR) Ventricular tachycardia revealing cardiac infiltration by mycosis fungoides. – P. Carrilho-Ferreira (Lisbon, PT) An autopsy that saves a family: A rare cause of ventricular hypertrophy. – J. Francisco Pascual (Caldes De Montbui, ES) Choronic myocarditis mimicking acute coronary syndrome due to eosinophilic state which is produced by pancreatic cancer. – D.-H. Jang (Buchen, KR) Exceptional cause of sudden cardiac death. – M. Llano (Santander, ES) A case of isolated coronary vasculitis. – K. Prakash (North Yorkshire, GB) Conclusion by the Chairpersons. 08:45 08:57 09:09 09:21 09:33 09:45 09:57 3901 3902 3903 3904 3905 3906 3907 10:00–11:00 | Moderated Posters - Village 10 MODIFIERS OF OUTCOME IN CORONARY ARTERY DISEASE Moderated Posters Chairperson(s): A.H.P. Linke (Leipzig, DE); F. Andreotti (Rome, IT) Posters must be set up between 08:00 and 08:30, removed between 12:30 and 13:00 and be on display from 08:30 to 12:30. The following abstracts were chosen for their outstanding quality and will be discussed in a special area in the Poster hall during the Moderated Poster Session chaired by the two above-mentioned chairpersons between 10:00 and 11:00. 10:00 10:07 10:15 10:22 10:30 10:37 10:45 10:52 232 NSAID use is associated with an increase in adverse cardiac events: 4-year results from the REACH registry. – P. Kohli, P.G. Steg, K. Crowley, S.A. Murphy, S. Goto, D.L. Bhatt (Boston, US; Paris, FR; Isehara, JP) History of stroke in patients with coronary artery disease in the REACH Registry: impact on cardiovascular and bleeding event rates. – G. Ducrocq, P. Amarenco, J. Labreuche, M. Alberts, J.L. Mas, M. Ohman, S. Goto, P. Lavallee, D.L. Bhatt, P.G. Steg (Paris, FR; Chicago, Durham and Boston, US; Kanagawa, JP) Triple anticoagulant therapy following an acute coronary syndrome: prevalence, bleeding rate and utility of the HAS-BLED score. – J. Van Der Pals, J.G. Smith, M. Wieloch, S. Koul, J. Lumsden, E. Rydell, J. Ohman, F. Schersten, P. Svensson (Lund and Malmo, SE) Women and men with stable coronary artery disease have similar cardiovascular outcomes: observations from an international prospective cohort of 30 977 patients from 45 countries. – R. Ferrari, I. Ford, K. Fox, N. Greenlaw, H. Abergel, S. Kaab, J.C. Tardif, M. Tendera, G. Steg, on behalf of the Clarify Registry Investigators (Lumezzan, IT; Glasgow and London, GB; Paris, FR; Munich, DE; Quebec, CA; Katowice, PL) Prognosis of unrecognized myocardial infarction in elderly men and women: the Rotterdam Study. – A. Dehghan, M.J.G. Leening, E. Boersma, J.W. Dekkers, J. Heeringa, J.A. Kors, A. Hofman, O.H. Franco, A. Ikram, J.C.M. Witteman (Rotterdam, NL) Impact of positive airway pressure therapy for cardiovascular outcomes in patients with coronary artery disease and sleep-disordered breathing. – K. Kato, Y. Takata, Y. Usui, K. Shiina, Y. Nishihata, A. Yamashina (Tokyo, JP) Time course of depressive symptoms and first coronary heart disease and stroke in older adults. A prospective observational study cohort: the Three-City study. – R. Pequignot, M.C.P. Perier, J.F.D. Dartigues, K.R. Ritchie, C.T. Tzourio, J.P.E. Empana (Paris, Bordeaux and Montpellier, FR) Prasugrel 5mg in the very elderly is non-inferior to prasugrel 10mg in non-elderly patients: the generations trial, a pharmacodynamic (PD) study in stable CAD patients. – D. Erlinge, P. Gurbel, S. James, T.L. Lindahl, P. Svensson, P.B. Brown, C. Zhou, J.A. Jakubowski, J.M. Ten Berg, D.J. Angiolillo (Lund, Uppsala, Linköping and Malmo, SE; Baltimore, Indianapolis and Jacksonville, US; Nieuwegein, NL) P3908 P3909 P3910 P3911 (W) P3912 P3913 P3914 P3915 TUESDAY, 28 AUGUST 2012 – MORNING SESSIONS 10:00–11:00 | Moderated Posters - Village 10 HEART FAILURE: WHAT CAN WE DO FOR YOU TODAY? Moderated Posters Chairperson(s): M.O. Dias Aguiar (São Paulo, BR); G. Ertl (Wurzburg, DE) Posters must be set up between 08:00 and 08:30, removed between 12:30 and 13:00 and be on display from 08:30 to 12:30. The following abstracts were chosen for their outstanding quality and will be discussed in a special area in the Poster hall during the Moderated Poster Session chaired by the two above-mentioned chairpersons between 10:00 and 11:00. 10:00 10:07 10:15 10:22 10:30 10:37 10:45 10:52 Two-dimensional strain measures of left ventricular systolic function are new independent predictors of ventricular arrhythmic events in chronic heart failure patients. – M. Iacoviello, A. Puzzovivo, C. Forleo, M.S. Lattarulo, F. Monitillo, V. Antoncecchi, G. Malerba, V. Marangelli, S. Favale (Bari, IT) Incremental prognostic value of left ventricular global longitudinal strain in patients with heart failure. – H. Motoki, A. Borowski, K. Shrestha, W. Tang, A. Klein (Cleveland, US) Quantitative left ventricular flow vortex analysis is superior to conventional echo-doppler to predict exercise capacity in patients with systolic heart failure. – G.R. Hong, Y.J. Choi, J.S. Lee, S.M. Kim, W.J. Park, J.W. Son, J.H. Choi, H. Houle, J.W. Ha, N.S. Chung (Seoul, Daegu and Busan, KR; Mountain View, US) The incremental prognostic value of inotropic contractile reserve combined with advanced mitral regurgitation in identifying responders to cardiac resynchronization therapy. – C. Aggeli, E. Poulidakis, I. Felekos, S. Sideris, P. Dilaveris, K. Gatzoulis, A. Katsaros, E. Sfendouraki, G. Roussakis, C. Stefanadis (Athens, GR) Improved differential diagnosis between left ventricular non-compaction and dilated cardiomyopathy. – B.E. Staehli, C. Gebhard, M. Greutmann, R. Jenni, F.C. Tanner (Zurich, CH) Visual assessment of apical rocking predicts response and long-term survival following cardiac resynchronization therapy. – I. Stankovic, M. Aarones, A. Ciarka, C. Prinz, M. Szulik, T. Kukulski, R. Willems, L. Faber, S. Aakhus, J.-U. Voigt (Leuven, BE; Oslo, NO; Bad Oeynhausen, DE; Zabrze, PL) Diagnostic and prognostic role of global longitudinal strain in patients with heart failure and normal ejection fraction. – P. Pellicori, A. Bennett, O. Khaleva, S. Hurren, V. Carubelli, N. Sherwi, K. Wong, A.L. Clark, J.G.F. Cleland (Hull, GB) Comparison of left ventricular discoordination and dyssynchrony assessment by radial strain imaging in candidates for cardiac resynchronization therapy. – Y.H. Chan, L.S. Wu, Y.H. Yeh, C.L. Wang, Y.J. Ho, L.A. Hsu, C.T. Kuo (Taoyuan, TW) P3916 P3917 (W) P3918 P3919 P3920 P3921 P3922 P3923 10:10–10:50 | Tbilisi - Central Village EUROPEAN UNION RESEARCH GRANT: HOW TO WRITE, APPLY AND SUCCEED Live streaming session How-to tutorial Chairperson(s): V. Dambrauskaite (Brussels, BE) 10:20 10:35 Introduction: rules, requirements and process. – V. Dambrauskaite (Brussels, BE) The role of peer review. – W.H. van Gilst (Groningen, NL) Questions and answers. 3924 3925 TUESDAY – MORNING 10:10 10:10–10:50 | Tirana - Central Village MEET THE GUIDELINES TASK FORCE II The Committee for Practice Guidelines Special Session Chairperson(s): J.J. Bax (Leiden, NL); U. Sechtem (Stuttgart, DE) 10:10 10:30 Acute myocardial infarction in patients presenting with ST-segment elevation: questions and answers to the panellists. – P.G. Steg (Paris, FR), S. James (Uppsala, SE), D. Atar (Oslo, NO), M.A. Borger (Leipzig, DE), A.H. Gershlick (Leicester, GB), A. Kastrati (Munich, DE), J.M. Knuuti (Turku, FI), P. Widimsky (Prague, CZ) Third universal definition of myocardial infarction: questions and answers to the panellists. – K. Thygesen (Aarhus, DK), J.S. Alpert (Tucson, US), B. Chaitman (St. Louis, US), A. Jaffe (Rochester, US), M.L. Simoons (Rotterdam, NL), H.D. White (Auckland, NZ) 3926 3927 233 TUESDAY, 28 AUGUST 2012 – MORNING SESSIONS 11:00–12:30 | Munich - Central Village HOT LINE III: LATE BREAKING TRIALS ON ARRHYTHMIAS AND CAD Hot Line Chairperson(s): K.A.A. Fox (Edinburgh, GB); D. Holmes (Rochester, US) 11:00 11:10 11:15 11:25 11:30 11:40 11:45 11:55 12:00 12:10 12:15 12:25 PRAGUE-12: Randomized open multicenter study comparing cardiac surgery with MAZE versus cardiac surgery without MAZE in patients with coronary and/or valvular heart disease and with atrial fibrillation. – P. Widimsky (Prague, CZ) Discussant. – R. Cappato (San Donato, IT) WOEST: First randomised trial that compares two different regimens with and without aspirin in patients on oral anticoagulant therapy (OAC) undergoing coronary stent placement (PCI). – W.J.M. Dewilde (Maaseik, BE) Discussant. – M. Valgimigli (Ferrara, IT) AFib Ablation Pilot: ESC-EURObservational Research Programme: 1-year follow-up of the Atrial Fibrillation Ablation Conducted by the European Heart Rhythm Association. – E. Arbelo (Las Palmas De Gran Canaria, ES) Discussant. – C. Leclercq (Rennes, FR) The Great East Japan Earthquake Disaster and Cardiovascular Diseases. – H. Shimokawa (Sendai, JP) Discussant. – G. Steinbeck (Munich, DE) CORE320: Diagnostic Performance of Combined Noninvasive Coronary Angiography and Myocardial Perfusion Imaging Using 320-row Detector Computed Tomography : The CORE320 Multicenter, Multinational Study. – J.A.C. Lima (Baltimore, US) Discussant. – G. Maurer (Vienna, AT) FAME II: Fractional Flow Reserve-Guided Percutaneous Coronary Intervention plus Optimal Medical Treatment versus Optimal Medical Treatment Alone in Patients with Stable Coronary Artery Disease. – B. De Bruyne (Aalst, BE) Discussant. – F. Van de Werf (Leuven, BE) 3928 3929 3930 3931 3932 3933 3934 3935 3936 3937 3938 3939 11:00–12:30 | Tbilisi - Central Village ESC GEOFFREY ROSE LECTURE ON POPULATION SCIENCES Named Lecture Chairperson(s): E. Swahn (Linköping, SE); V. Conraads (Edegem, BE) 11:00 Announcement by the chairpersons. 11:02 Presentation of the awardee. – J.E. Deanfield (London, GB) 3940 11:07 Cholesterol and risk: past, present and future. – R.E. Collins (Oxford, GB) 3941 11:43 Diploma by the chairpersons. ESC RENE LAENNEC LECTURE ON CLINICAL CARDIOLOGY Named Lecture Chairperson(s): E. Swahn (Linköping, SE); V. Conraads (Edegem, BE) 234 11:45 Announcement by the chairpersons. 11:47 Presentation of the awardee. – T.F. Luescher (Zurich, CH) 3942 11:52 New look at atrial fibrillation: lessons from drug, pacemaker and ablation therapies. – L. Kappenberger (Lausanne, CH) 3943 12:28 Diploma by the chairpersons. TUESDAY, 28 AUGUST 2012 – MORNING SESSIONS 11:00–12:30 | Tirana - Central Village TAKE HOME MESSAGE FOR PRACTITIONERS In collaboration with the Council for Cardiology Practice Symposium Chairperson(s): P.A. Sirnes (Moss, NO); G. Baron Esquivias (Seville, ES) 11:00 11:18 11:36 11:54 12:12 Prevention, hypertension and peripheral artery disease - update 2012. – D.L. Clement (Ghent, BE) Heart failure update 2012. – B. Pieske (Graz, AT) Coronary artery disease update 2012. – S. Silber (Munich, DE) Cardiovascular imaging update 2012. – A. Yilmaz (Ostfildern, DE) Arrhythmia and pacing update 2012. – A. Moya I Mitjans (Barcelona, ES) 3944 3945 3946 3947 3948 11:00–12:30 | Beirut - Village 1 FROM BENCH TO PRACTICE: UNDERSTANDING ARRHYTHMIAS – LESSONS FROM GENETICS Symposium Chairperson(s): K.R. Sipido (Leuven, BE); S.G. Priori (Pavia, IT) 11:00 11:22 11:45 12:07 Genomic approaches to Brugada syndrome. – C.R. Bezzina (Amsterdam, NL) From genome-wide association studies to atrial fibrilation. – D. Franco (Jaen, ES) Rare variants associated with sick sinus syndrome. – H. Holm (Mosfellsbaer, IS) Strengths and limitations of genomic approaches. – S. Kaab (Munich, DE) 3949 3950 3951 3952 11:00–12:30 | Riga - Village 1 FROM BENCH TO PRACTICE: CHEMOTHERAPY-INDUCED CARDIOTOXICITY – THE PARADOX OF DAMAGED HEARTS AND PROLONGED LIVES Symposium Chairperson(s): T.M. Suter (Berne, CH); S. Engelhardt (Munich, DE) 11:00 11:22 11:45 12:07 Alterations in myocardial energy metabolism induced by anti-cancer drugs. – M. Tokarska-Schlattner (Grenoble, FR) Type I and type II cardiotoxicity - does bench work explain the clinical findings? – S. Zbinden (Berne, CH) Induction of myocardial regeneration to attenuate cardiotoxicity. – D. Hilfiker-Kleiner (Hannover, DE) State of the art: reducing cardiotoxicity. – T.L. Force (Philadelphia, US) 3953 3954 3955 3956 11:00–12:30 | Tripoli - Village 1 THE ENDOTHELIUM: KEY PLAYER IN VASCULAR CONTROL Abstract Session Chairperson(s): J.D. Pearson (London, GB); F.A. Snyders (Pretoria, ZA) 11:15 11:30 11:45 12:00 12:15 Reduced leukocyte telomere length are associated with increased levels of vascular oxidative stress in patients with acute myocardial infarction. – J. Lorin, S. Saliques, J.C. Guilland, S. Ragot, A. Donzel, J.R. Teyssier, Y. Cottin, L. Rochette, C. Vergely, M. Zeller (Dijon, FR) Circulating plasma free heme levels correlate with endothelial injury and atherosclerotic lesions extent in patients with stable coronary artery disease. – N. Amabile, C. Guerin, C. Caussin, O. Blanc-Brude, C.M. Boulanger (Le Plessis-Robinson and Paris, FR) Changes in blood flow determine endothelial vasomotor responses: insight into the meaning of flow-mediated constriction and dilation. – F. Fasola, A. Beutel, S. Muxel, S. Schaefer, A. Damaske, M. Vosseler, J.D. Parker, T. Munzel, T. Gori (Mainz, DE; Toronto, CA) Epigenetic regulation of cell adhesion and communication by enhancer of zeste homolog 2 in human endothelial cells. – H. Dreger, A. Ludwig, A. Weller, V. Stangl, G. Baumann, S. Meiners, K. Stangl (Berlin and Munich, DE) The effects of AdVEGF-B and AdVEGF-D on angiogenesis and arteriogenesis in a novel porcine model of percutaneous bottleneck stent induced chronic myocardial ischemia. – J. Nurro, P.J. Halonen, T.T. Rissanen, A. Kuivanen, K.M. Honkonen, H. Karvinen, S. Yla-Herttuala (Kuopio, FI) Protection against stroke through preservation of vascular integrity by angiopoietin-like 4 (ANGPTL4). – C. Bouleti, T. Mathivet, B. Coqueran, C. Monnot, I. Margaill, S. Germain (Paris, FR) 3957 TUESDAY – MORNING 11:00 3958 3959 3960 3961 3962 235 TUESDAY, 28 AUGUST 2012 – MORNING SESSIONS 11:00–12:30 | Algiers - Village 2 LESSONS LEARNT FROM NEGATIVE TRIALS Clinical Seminar Chairperson(s): S.E. Kjeldsen (Oslo, NO); G.M.C. Rosano (Rome, IT) 11:00 11:22 11:45 12:07 Intense blood pressure lowering. – B. Dahlof (Gothenburg, SE) Intense glycaemic control. – A. Cicero (Bologna, IT) Selective high-density lipoprotein targeting. – P.J. Barter (Sydney, AU) Antiarrhythmic drugs. – S.H. Hohnloser (Frankfurt, DE) 3963 3964 3965 3966 11:00–12:30 | Berlin - Village 2 DRUG TREATMENT AND COMPLIANCE IN HYPERTENSION Abstract Session Chairperson(s): J. Brguljan (Ljubljana, SI); To be announced 11:00 11:15 11:30 11:45 12:00 12:15 A national, multicentre, randomized controlled trial of the efficacy of structured care algorithm in achieving individual blood pressure targets at 26 weeks in primary care. – S. Stewart, M.J. Carrington, C.H. Swemmer, N.P. Kurstjens, G.J. Jennings (Melbourne and Sydney, AU) Antihypertensive and laxative effects by inhibition of NHE3-mediated sodium absorption in the gut. – D. Linz, K. Wirth, W. Linz, P. Arndt, U. Schwahn, M. Böhm, H. Ruetten (Homburg and Frankfurt/Main, DE) Predictive factors of adherence in uncontrolled hypertensive patients in France: results of the observational real life survey HBP-ADHERENCE. – J.-J. Mourad, C. Mounier-Vehier, F. Liard, F. Beauvais (Paris, Lille and Saint Epain, FR) Valsartan suppresses cardiovascular events in hypertensive subjects with diabetes mellitus (DM) comparable to those with impaired glucose tolerance (IGT). – T. Kondo, K. Yamashita, T. Muramatsu, K. Matsushita, T. Nagahiro, K. Maeda, S. Shintani, T. Murohara (Nagoya, JP) Impact of intensive blood pressure lowering therapy on left atrial volume and function and the incidence of first atrial fibrillation in elderly hypertensive patients with preserved systolic function. – T. Watanabe, R. Tanaka, K. Ono, S. Minatoguchi, S. Abe, M. Iwama, T. Noda, S. Watanabe, M. Kawasaki, S. Minatoguchi (Gifu, JP) Pilot analysis of the effect of the SGLT2 inhibitor dapagliflozin on blood pressure in patients with type 2 diabetes mellitus: a pooled analysis of placebo controlled trials. – C.D. Sjostrom, J. Sugg, C. Tjoen, A. Salsali, A. Ptaszynska, S. Parikh (Molndal, SE; Wilmington and Princeton, US; Braine l’Alleud, BE) 3967 3968 3969 3970 3971 3972 11:00–12:30 | Zagreb - Village 2 HOW TO PREVENT BRAIN DAMAGE IN HYPERTENSION? Clinical Seminar Chairperson(s): G. Kamensky (Bratislava, SK); N.V. Deshpande (Nagpur, IN) 11:00 11:22 11:45 12:07 236 How to prevent stroke in hypertension? – E. Agabiti-Rosei (Brescia, IT) How to manage blood pressure in acute ischaemic stroke? – E. Berge (Oslo, NO) Management of blood pressure after stroke. – S. Lueders (Cloppenburg, DE) Progression of white matter lesions, microbleeds and cognitive decline in hypertensive patients. – A. Coca (Barcelona, ES) 3973 3974 3975 3976 TUESDAY, 28 AUGUST 2012 – MORNING SESSIONS 11:00–12:30 | Athens - Village 3 SPORT CARDIOLOGY – PRE-PARTICIPATION SCREENING: CONSEQUENCES AND PITFALLS Abstract Session Chairperson(s): T. Meyer (Saarbrücken, DE); F. Carre (Rennes, FR) 11:00 11:15 11:30 11:45 12:00 12:15 Exercise related out-of-hospital cardiac arrest: incidence, prognosis, and prevention of sudden death. – J. Berdowski, M.F. De Beus, A. Bardai, M.L. Bots, P.A. Doevendans, D.E. Grobbee, H.L. Tan, J.G.P. Tijssen, R.W. Koster, A. Mosterd (Amsterdam, Utrecht and Amersfoort, NL) Costs of cardiovascular screening with ECG in young athletes in Switzerland. – A. Menafoglio, M. Di Valentino, P. Siragusa, M. Maggi, G.A. Romano, R. Pezzoli, G. Moschovitis, A. Gallino (Bellinzona, Locarno and Lugano, CH) Concentric remodelling of the right ventricle in African football players. – G.F. Gjerdalen, J. Hisdal, E.E. Solberg, T.E. Andersen, Z. Radunovic, K. Steine (Oslo, NO) Prevalence of significant ECG abnormalities in elite Australian athletes. – M. Brosnan, A. La Gerche, J. Kalman, K. Fallon, A. Mac Isaac, W. Lo, D. Prior (Melbourne and Canberra, AU) Prevalence of Brugada ECG-pattern recorded with V1 and V2 in the third intercostals space in young athletes. – A. Menafoglio, M. Di Valentino, M. Siragusa, G. Moschovitis, A. Gallino (Bellinzona, Locarno and Lugano, CH) Sudden cardiac death risk assessment, combining cardiorespiratory fitness with cardiovascular risk factors. – M. Hagnas, S. Kurl, R. Rauramaa, T.H. Makikallio, J.A. Laukkanen (Rovaniemi, Kuopio and Oulu, FI) 3977 3978 3979 3980 3981 3982 11:00–12:30 | Nicosia - Village 3 IMPLANTABLE DEFIBRILLATORS: TREATING THE PATIENT NOT THE DEVICE Clinical Seminar Chairperson(s): G. Hamilton (Svartskog, NO); J. Boyne (Maastricht, NL) 11:00 11:22 11:45 12:07 Comprehensive rehabilitation. – S. Kikkenborg Berg (Copenhagen, DK) Reducing psychological distress for patients with implantable cardioverter-defibrillators. – S.S. Pedersen (Tilburg, NL) Promoting exercise in patients with implantable cardioverter-defibrillators. – M. Wilhelm (Berne, CH) Decisions at the end of life. – J.M. Beattie (Birmingham, GB) 3983 3984 3985 3986 11:00–12:30 | Yerevan - Village 3 HOW TO IMPROVE ASSESSMENT OF CARDIOVASCULAR RISK? Symposium Chairperson(s): T. Zdrojewski (Sopot, PL); F.D.R. Hobbs (Oxford, GB) 11:22 11:45 12:07 Principles of cardiovascular disease risk prediction. – D.A. Wood (London, GB) The role of genetics in cardiovascular risk assessment. – R. Ploski (Warsaw, PL) Promising strategies - American perspective. – M. Pencina (Boston, US) Promising strategies - European perspective. – I.M. Graham (Dublin, IE) 3987 3988 3989 3990 TUESDAY – MORNING 11:00 11:00–12:30 | Budapest - Village 4 UPDATE ON ANTITHROMBOTICS IN ACUTE CORONARY SYNDROMES Clinical Seminar Chairperson(s): J.C.A. Morais (Leiria, PT); F.W.A. Verheugt (Amsterdam, NL) 11:00 11:22 11:45 12:07 P2Y12 blockade. To load or not to load before the cath lab? – F.J. Neumann (Bad Krozingen, DE) Intravenous anticoagulants. – G. Montalescot (Paris, FR) Oral anti-Xa agents. A new opportunity? – J. Alexander (Durham, US) Thrombus aspiration. The best antithrombotic? – F. Burzotta (Rome, IT) 3991 3992 3993 3994 237 TUESDAY, 28 AUGUST 2012 – MORNING SESSIONS 11:00–12:30 | Prague - Village 4 FROM BENCH TO PRACTICE: CORONARY MICROVASCULAR DYSFUNCTION Clinical Seminar Chairperson(s): C. De Wit (Lübeck, DE); M. Yamagishi (Kanazawa, JP) 11:00 11:22 11:45 12:07 Pathophysiology of coronary microvascular dysfunction. – F. Crea (Rome, IT) Clinical assessment of coronary microcirculation. – U. Sechtem (Stuttgart, DE) Coronary microvascular dysfunction in stable coronary artery disease. – C.J. Pepine (Gainesville, US) Coronary microvascular dysfunction in acute coronary syndromes. – R. Bugiardini (Bologna, IT) 3995 3996 3997 3998 11:00–12:30 | Vienna - Village 4 FROM BENCH TO PRACTICE: MODULATION OF THE SYMPATHETIC NERVOUS SYSTEM Clinical Seminar Chairperson(s): M. Böhm (Homburg/Saar, DE); K. Swedberg (Gothenburg, SE) 11:00 11:22 11:45 12:07 Spinal cord stimulation for refractory angina. – G.A. Lanza (Rome, IT) Vagal stimulation for heart failure: an example of translational cardiology. – P.J. Schwartz (Pavia, IT) Renal denervation for refractory hypertension. – H. Krum (Melbourne, AU) Sympathetic cardiac denervation for refractory spasm. – A. Abbate (Richmond, US) 3999 4000 4001 4002 11:00–12:30 | Baku - Village 5 HEART FAILURE THERAPIES: LATEST EVIDENCE Symposium Chairperson(s): G. Jondeau (Paris, FR); G. Sinagra (Trieste, IT) 11:00 11:22 11:45 12:07 Patient monitoring. – M.R. Cowie (London, GB) Medical therapy. – J.R. Teerlink (San Francisco, US) Electrical devices. – K. Dickstein (Stavanger, NO) Ventricular assist devices. – A. Pitsis (Thessaloniki, GR) 4003 4004 4005 4006 11:00–12:30 | Copenhagen - Village 5 VALVE DISEASE IN PATIENTS WITH HEART FAILURE Symposium Chairperson(s): N. Moat (London, GB); G.C. Schuler (Leipzig, DE) 11:00 11:22 11:45 12:07 238 The assessment of aortic stenosis in patient with myocardial dysfunction. – J.-L. Monin (Créteil, FR) Transcatheter aortic valve implantation or surgery? – M. Sousa Uva (Lisbon, PT) Mitral regurgitation: when is a procedure needed? – P. Lancellotti (Liège, BE) Surgical or interventional therapy for mitral regurgitation in heart failure. – O. Alfieri (Brescia, IT) 4007 4008 4009 4010 TUESDAY, 28 AUGUST 2012 – MORNING SESSIONS 11:00–12:30 | Reykjavik - Village 5 HEART FAILURE: FEAST OR FAMINE? Abstract Session Chairperson(s): W. Doehner (Berlin, DE); M. Lainscak (Golnik, SI) 11:00 11:15 11:30 11:45 12:00 12:15 Alteration of gene expression profiling of the murine intestine suffering from heart failure. – A. Takahashi, M. Asakura, K.D. Min, S. Ito, K. Shindo, Y. Yan, H. Liu, H. Asanuma, N. Mochizuki, M. Kitakaze (Suita and Kyoto, JP) Preceding starvation prevents acute doxorubicin cardiotoxicity via autophagy activation. – T. Kawaguchi, G. Takemura, H. Kanamori, A. Tsujimoto, T. Takeyama, T. Watanabe, K. Morishita, H. Fujiwara, T. Fujiwara, S. Minatoguchi (Gifu, JP) Obesity paradox in patients with acute heart failure: application of propensity score methodology in an acute heart failure database AHEAD. – S. Littnerova, J. Jarkovsky, J. Parenica, J. Spinar, J. Vitovec, P. Widimsky, A. Linhart, M. Fedorco, F. Malek, C. Cihalik (Brno, Prague and Olomouc, CZ) Does admission pre-albumin predict in-hospital mortality in acute heart failure patients? – P. Lourenco, S. Silva, F. Frioes, M. Alvelos, P. Torres Ramalho, T. Guimaraes, P. Bettencourt (Porto, PT) Are total cholesterol levels important for hospital and long time prognosis of patients with acute heart failure? – L. Spinarova, J. Spinar, A. Linhart, P. Widimsky, M. Fedorco, F. Malek, C. Cihalik, L. Dusek, J. Jarkovsky, J. Parenica (Brno, Prague, Olomouc and Zlin, CZ) The prognostic importance of evaluating nutritional status in patients with chronic heart failure. – T. Narumi, T. Arimoto, T. Watanabe, S. Kadowaki, Y. Otaki, H. Takahashi, T. Shishido, T. Miyashita, T. Miyamoto, I. Kubota (Yamagata, JP) 4011 4012 4013 4014 4015 4016 11:00–12:30 | Cairo - Village 6 CONTROVERSIES IN VALVULAR HEART SURGERY Symposium Chairperson(s): K. Vanermen (Aalst, BE); V. Falk (Zurich, CH) 11:00 11:22 11:45 12:07 Mitral valve annuloplasty in ischaemic mitral regurgitation. – J.-F. Avierinos (Marseille, FR) Patient-prosthesis mismatch. – J. Magne (Liège, BE) When and how to treat. – M.A. Borger (Leipzig, DE) Mitral repair in asymptomatic patients. – M. De Bonis (Milan, IT) 4017 4018 4019 4020 11:00–12:30 | Dublin - Village 6 RESTENOSIS: STILL THE ACHILLES HEEL OF PERCUTANEOUS CORONARY INTERVENTIONS? Abstract Session Chairperson(s): S.T. Lim (Singapore, SG); D. Locca (Lausanne, CH) 11:15 11:30 11:45 12:00 12:15 Impact of stent fracture on long-term clinical outcomes after sirolimus-eluting stent implantation. – Y. Fuku, K. Kadota, K. Mitsudo, T. Goto, N. Oka, H. Tanaka, T. Tada, S. Habara, Y. Shigemoto, D. Hasegawa (Kurashiki, JP) Stent fracture and restenosis at stent fracture site after sirolimus-eluting stent and everolimus-eluting stent implantations: impact of stented vessel. – K. Miyake, K. Kadota, T. Tada, H. Tanaka, Y. Fuku, N. Oka, H. Katoh, H. Yamamoto, T. Goto, K. Mitsudo (Kurashiki, JP) Decreased interleukin-33 serum levels after coronary stent implantation are protective against in-stent restenosis. – S. Demyanets, R. Jarai, K. Katsaros, S. Farhan, A. Wonnerth, G. Maurer, W.S. Speidl, J. Wojta, K. Huber (Vienna, AT) Efficiency of statin treatment on EPC recruitment depends on baseline EPC titer, and does not improve angiographic outcome in coronary artery disease patients treated with the Genous stent. – W. Den Dekker, J.H. Houtgraaf, S.M. Rowland, S.P.M. De Boer, R.J. De Winter, P. Den Heijer, F. Zijlstra, P.W. Serruys, C. Cheng, H.J. Duckers (Rotterdam, Amsterdam and Breda, NL; Fort lauderdale, US) Drug-eluting stents for the treatment of chronic total occlusion: a comparison with sirolimus, paclitaxel, zotarolimus, biolimusA9, EPC capture and everolimus-eluting stent: multicenter registry. – S. Nakamura, H. Ogawa, J.H. Bae, Y.H. Cahyadi, W. Udayachalerm, D. Tresukosol, S. Tansuphaswadikul (Chiba and Kumamoto, JP; Daejeon, KR; Jakarta, ID; Bangkok, TH) Differences in progression pattern of late restenosis after drug-eluting stent implantation. – S. Otsuru, K. Kadota, D. Hasegawa, S. Habara, T. Tada, H. Tanaka, Y. Fuku, N. Oka, T. Goto, K. Mitsudo (Kurashiki, JP) 4021 4022 4023 TUESDAY – MORNING 11:00 4024 4025 4026 239 TUESDAY, 28 AUGUST 2012 – MORNING SESSIONS 11:00–12:30 | Minsk - Village 6 BURNING ISSUES IN PERCUTANEOUS CORONARY IMAGING FOR ACUTE CORONARY SYNDROMES Main Session Chairperson(s): M. Haude (Neuss, DE); T.-H. Koh (Singapore, SG) 11:00 11:22 11:45 12:07 Role of risk scores. – A. Lerman (Rochester, US) Should non ST-elevation myocardial infarction be treated as rapidly as ST-elevation myocardial infarction? – M. Dalby (Harefield, GB) Antiplatelet therapy: which drugs and for how long? – F. Weidinger (Vienna, AT) Specifics of acute coronary syndrome management in the elderly. – S. Savonitto (Reggio Emilia, IT) 4027 4028 4029 4030 11:00–12:30 | Brussels - Village 7 UPDATE ON CONSENSUS STATEMENT ON MANAGEMENT OF ATRIAL FIBRILLATION: EUROPEAN HEART RHYTHM ASSOCIATION 2012 Symposium Chairperson(s): A. Auricchio (Lugano, CH); P. Kirchhof (Birmingham, GB) 11:00 11:22 11:45 12:07 Atrial fibrillation ablation: in whom and how. Update of HRS/EHRA AF/ECAS ablation document 2012. – A. Gillis (Calgary, CA) Update on ESC AF guidelines on medical therapy 2012. – A.J. Camm (London, GB) Management of patients with cardiac resynchronisation devices: consensus recommendations from EHRA, HFA, HRS, and HFSA. – J.C. Daubert (Rennes, FR) Electrophysiological procedures in children - who, when, and how? Consensus EHRA/Association for European Paediatric Cardiology statement. – J. Brugada Terradellas (Barcelona, ES) 4031 4032 4033 4034 11:00–12:30 | Tallinn - Village 7 CONTROVERSIAL ISSUES: IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR IMPLANTATION Debate Session Chairperson(s): L. Mont (Barcelona, ES); L. Jordaens (Rotterdam, NL) Defibrillation testing should be routinely performed at the time of implantable cardioverter-defibrillator implantation 11:00 11:15 11:30 11:35 11:40 Pro. – J. Healey (Hamilton, CA) Contra. – F. Arribas (Madrid, ES) Rebuttal. 4035 Pro. – J. Healey (Hamilton, CA) Contra. – F. Arribas (Madrid, ES) Conclusion. 4037 4036 4038 Warfarin should be stopped before implantable cardioverter-defibrillator implantation 11:45 12:00 12:15 12:20 12:25 240 Pro. – A. Da Costa (Saint Etienne, FR) Contra. – C. Wolpert (Ludwigsburg, DE) Rebuttal. 4039 Pro. – A. Da Costa (Saint Etienne, FR) Contra. – C. Wolpert (Ludwigsburg, DE) Conclusion. 4041 4040 4042 TUESDAY, 28 AUGUST 2012 – MORNING SESSIONS 11:00–12:30 | Tel Aviv - Village 7 BALANCING STROKE PREVENTION VERSUS BLEEDING RISK IN ATRIAL FIBRILLATION Abstract Session Chairperson(s): B. Gorenek (Eskisehir, TR); E. Hoffmann (Munich, DE) 11:00 11:15 11:30 11:45 12:00 12:15 Regional differences in the use of antithrombotic therapy for stroke prevention in atrial fibrillation: European and Asian insights from the Global Anticoagulant Registry in the FIELD (GARFIELD). – S. Goto, I. Mueller, D.A. Fitzmaurice, S. Haas, G.Y.H. Lip, A.G.G. Turpie, S.Z. Goldhaber, S. Rushton-Smith, A.K. Kakkar (Kanagawa, JP; London and Birmingham, GB; Munich, DE; Hamilton, CA; Boston, US) The HEMORR2HAGES, ATRIA and the HAS-BLED bleeding risk prediction scores in anticoagulated atrial fibrillation patients: the AMADEUS study. – S. Apostolakis, D.A. Lane, H. Buller, G.Y.H. Lip (Birmingham, GB; Amsterdam, NL) Events after discontinuation of randomized treatment at the end of the ARISTOTLE trial. – C.B. Granger, J.H. Alexander, M. Hanna, J. Wang, P. Mohan, J. Lawrence, E. Hylek, J.E. Ansell, L. Wallentin (Durham, Princeton, Boston and New York, US; Uppsala, SE) CHA2DS2VASc score and thromboembolic and bleeding complications after successful cardioversion of acute atrial fibrillation. – T. Gronberg, J. Hartikainen, I. Nuotio, M. Nikkinen, A. Ylitalo, J. Airaksinen (Turku, Kuopio and Pori, FI) Stroke prevention in non-valvular atrial fibrillation: long-term results after 6 years of the watchman left atrial appendage occlusion pilot study. – P.B. Sick, Z. Turi, E. Grube, S. Moebius-Winkler, G. Schuler, G. Mishkel, S. Yakubov, S. Almany, D. Holmes (Regensburg, Bonn and Leipzig, DE; Camden, Springdale, Columbus, Michigan and Rochester, US) Apixaban and warfarin are associated with a low risk of stroke following cardioversion for atrial fibrillation: results from the ARISTOTLE Trial. – G. Flaker, R. Lopes, S. Al-Khatib, A. Hermosillo, L. Thomas, J. Zhu, W. Ruzyllo, P. Mohan, C. Granger, L. Wallentin (Columbia, Durham and New York, US; Mexico City, MX; Beijing, CN; Warsaw, PL; Uppsala, Sweden, SE) 4043 4044 4045 4046 4047 4048 11:00–12:30 | Helsinki - Village 8 HOW TO MANAGE IDIOPATHIC PULMONARY HYPERTENSION IN AN EMERGENCY How-to Session Chairperson(s): M. Delcroix (Leuven, BE); J.S.R. Gibbs (London, GB) 11:00 11:45 Pulmonary arterial hypertension with frequent syncope. – J.L. Vachiery (Brussels, BE) Emergency management of acute deterioration of pulmonary arterial hypertension. – N. Galie (Bologna, IT) 4049 4050 11:00–12:30 | Rome - Village 8 GENETIC TESTING FOR CARDIOMYOPATHIES IN CLINICAL PRACTICE ESC and the European Society of Human Genetics Symposium Chairperson(s): P.M. Elliott (London, GB); J. Schmidtke (Hannover, DE) 11:18 11:36 11:54 12:12 Twenty years of genetic research. – P. Charron (Paris, FR) The impact of genetic testing on clinical management. – J. Mogensen (Aarhus, DK) Molecular testing: strategies, pitfalls and future perspectives. – S. Fokstuen (Geneva, CH) Genetic counselling and ethical aspects of genetic testing. – I. Christiaans (Amsterdam, NL) Towards cardiomyopathy units integrating genetics. – P.P. McKeown (Belfast, GB) 4051 4052 4053 4054 4055 TUESDAY – MORNING 11:00 11:00–12:30 | Sarajevo - Village 8 UPDATE OF THE TASK FORCE ON MYOCARDITIS Clinical Seminar Chairperson(s): W.J. McKenna (London, GB); Y. Pinto (Amsterdam, NL) 11:00 11:22 11:45 12:07 Clinical diagnostic criteria. – A.L.P. Caforio (Padua, IT) Molecular diagnostic criteria. – S. Pankuweit (Marburg, DE) Primary and secondary arrhythmia management. – F. Hidden Lucet (Paris, FR) Aetiology-directed therapy: current gaps and future directions. – S. Heymans (Maastricht, NL) 4056 4057 4058 4059 241 TUESDAY, 28 AUGUST 2012 – MORNING SESSIONS 11:00–12:30 | Paris - Village 9 Symposium ADVANCES IN E-CARDIOLOGY Chairperson(s): G. Krstacic (Zagreb, HR); E.G. Caiani (Milan, IT) 11:00 11:22 11:45 12:07 In image processing. – N. Bruining (Rotterdam, NL) In cardiac signal analyses. – M. Malik (Purley, GB) In telecardiology. – E.T. van der Velde (Leiden, NL) In cardiac risk stratification. – G. Schmidt (Munich, DE) 4060 4061 4062 4063 11:00–12:30 | Pristina - Village 9 CORONARY ARTERY DISEASE: FROM THE DARK TO THE LIGHT OF MULTIDETECTOR COMPUTED TOMOGRAPHY Abstract Session Chairperson(s): K. Nieman (Rotterdam, NL); H.J. Ukkonen (Turku, FI) 11:00 11:15 11:30 11:45 12:00 12:15 Ring-like sign on coronary computed tomographic angiography is associated with near-future acute coronary syndrome in patients with coronary artery disease. – K. Otsuka, S. Fukuda, A. Tanaka, K. Nakanishi, M. Sakamoto, H. Taguchi, J. Yoshikawa, K. Shimada, M. Yoshiyama (Osaka, Tanabe and Nishinomiya, JP) Combined CT angiography and CT myocardial perfusion imaging to detect functionally significant stenoses in patients with suspected coronary artery disease - comparison with fractional flow reserve. – B.S.H. Ko, J.D. Cameron, I.T. Meredith, M. Leung, P.R. Antonis, M. Crossett, S.K. Seneviratne (Melbourne, AU) Prevalence of coronary artery anomalies in 8,002 consecutive patients: study with coronary computed tomography angiography. – M.P. Opolski, C. Kepka, J. Pregowski, M. Kruk, S. Kwiecinska, E. Lubienska, M. Demkow, W. Ruzyllo, A. Witkowski (Warsaw, PL) Association between findings of multidetector computed tomography and coronary flow throughout Percutaneous Coronary Intervention. – Y. Osaka, S. Kimura, S. Kuroda, N. Kawaguchi, E. Nakashima, T. Sugiyama, D. Akiyama, T. Kamiishi, H. Hikita, M. Isobe (Yokosuka and Tokyo, JP) Prognostic significance of pre-test probability of coronary artery disease to coronary CT angiography in patients with coronary calcium score zero. – N. Yokoyama, R.I. Iino, K.K. Kumiko Konno, T.I. Takaaki Isshiki (Tokyo, JP) Impact of lipid lowering on prevention of plaque progression detected by coronary computed tomography angiography. – H. Ito, S. Motoyama, M. Sarai, H. Kawai, H. Harigaya, H. Naruse, S. Kan, S. Kato, J. Ishii, Y. Ozaki (Toyoake, JP) 4064 4065 4066 4067 4068 4069 11:00–12:30 | Sofia - Village 9 IMAGING IN THE DECISION MAKING OF CHRONIC CORONARY ARTERY DISEASE ESC and the American College of Cardiology Symposium Chairperson(s): L. Badano (Padua, IT); M.A. Quinones (Houston, US) 11:00 11:22 11:45 12:07 Does the STICH trial provide a definitive answer? – J. Panza (Washington, US) Stress echo: usefulness and limitations. – R. Sicari (Pisa, IT) What information can single-photon emission computed tomography and/or positron emission tomography provide? – M.F. Di Carli (Boston, US) How can cardiac magnetic resonance help? – S. Plein (Leeds, GB) 4070 4071 4072 4073 11:00–12:30 | London - Village 10 2012 GREAT DEBATE: CURRENT ROLE OF INTERVENTIONAL RENAL DENERVATION IN THE TREATMENT OF SEVERE HYPERTENSION In collaboration with EAPCI - EuroPCR Focus Imaging Intervention Chairperson(s): W. Wijns (Aalst, BE); I. Durand-Zaleski (Créteil, FR) Panel. – F. Mahfoud (Homburg/Saar, DE), W. McKane (Sheffield, GB), P.F. Plouin (Paris, FR), J.R. Renkin (Sterrebeek, BE), L.M. Ruilope (Madrid, ES), T. Zeller (Bad Krozingen, DE) 242 4074 TUESDAY, 28 AUGUST 2012 – MORNING SESSIONS 11:00–12:30 | The Hague - Village 10 HOW TO DEAL WITH HIGH-RISK PREGNANCIES? Focus Cardiology Practice Chairperson(s): J.W. Roos-Hesselink (Rotterdam, NL); P. Tornos Mas (Barcelona, ES) Severe mitral stenosis. Aortic dilatation. Acute coronary syndrome. Panel. – J. De Backer (Ghent, BE), B. Iung (Paris, FR), M. Schwerzmann (Berne, CH), E. Thaulow (Oslo, NO), S. Thorne (Birmingham, GB) 4075 11:00–12:30 | Case Corner - Village 10 CASE-BASED LEARNING FROM THE ESC CARDIOLOGISTS OF TOMORROW: LOOK FOR THE ANSWER OUTSIDE THE HEART Clinical Cases Chairperson(s): S. Zuily (Vandoeuvre-lès-Nancy, FR); J. Silva-Cardoso (Porto, PT) Introduction by the Chairpersons. 11:03 Cardiac storm: an unusual course of cardiomyopathy due to amyloidosis associated with multiple myeloma, presenting with myocardial infarction, diastolic heart failure, and conduction defects. – P. Gosciniak (Bezrzecze, PL) Intracardiac leiomyomatosis complicated with pulmonary embolism. – V. Ribeiro (Porto, PT) Cardiac involvement in the hypereosinophilic syndrome. – E. McAlindon (Bristol, GB) Brugada type ECG: unmasked by a pheochromocytoma. – A. Khan (Cork, IE) Immunosuppression of recurrent pericardial graft versus host disease. – A.C. Morley-Smith (London, GB) Mediastinal Paraganglioma: a challenge to the echocardiographic diagnosis and endovascular treatment. – S. Raposeiras Roubin (Pontevedra, ES) An unexpected cause of right atrial mass. – T. Pereira-Da-Silva (Lisbon, PT) Conclusion by the Chairpersons. 11:15 11:27 11:39 11:51 12:03 12:15 12:27 4076 4077 4078 4079 4080 4081 4082 TUESDAY – MORNING 11:00 243 TUESDAY, 28 AUGUST 2012 – MORNING POSTERS 08:30–12:30 | Posters - Village 10 POSTER SESSION 5 Poster Session Posters must be set up between 08:00 and 08:30, removed between 12:30 and 13:00 and be on display from 08:30 to 12:30.The presenter should be present throughout the coffee break (10:00 to 11:00) in order to discuss the Poster. GENETIC ASPECTS/VENTRICULAR ARRYTHMIAS Outcome of screening of relatives to patients with long QT syndrome; a nationwide Danish study. – J. Theilade, J. Kanters, F.L. Henriksen, M. Gilsaa-Hansen, J. Hastrup-Svendsen, O. Eschen, A. Tybjaerg-Hansen, M. Christiansen, H.K. Jensen, H. Bundgaard (Copenhagen, Odense, Haderslev, Aalborg and Aarhus, DK) The australian national genetic heart disease registry. – J. Ingles, T. Sarina, A. Evans, J. Kawa, R. Weintraub, J. Vohra, I. Winship, J. Mcgaughran, J. Atherton, C. Semsarian (Sydney, Launceston, Melbourne and Brisbane, AU) A new MOG1 transcript variant implicated in arrhythmias. – V. Novelli, M. Cerrone, S. Crespo-Carbone, R. Bloise, C. Napolitano, S.G. Priori (New York, US; Pavia, IT) A novel mutation affecting the transmembrane domain of the KCNJ2 protein is associated with high prevalence of life-threatening ventricular arrhythmias in a family with andersen-tawil syndrome. – E. Fernlund, C. Lundin, E. Hertervig, O. Kongstad, M. Alders, P.G. Platonov (Lund, SE; Amsterdam, NL) A novel SCN5A missense gene mutation causing LQT3 syndrome in a large Canadian first nations family. – M.J. Gardner, M.J. Gardner, C. Gray, J. Marcadier, A. Crowley, J. Hathaway, A. Warren, S. Dyack (Halifax, CA) Evidence for a heritable contribution to death from atrial fibrillation. – N.F. Marrouche, B.D. Wilson, K. Damal, L. Cannon-Albright (Salt Lake City, US) Inherited cardiovascular diseases (ICVDs) in the every day clinical practice: diagnostic yield and genetic family screening. – A. Anastasakis, X. Kotsaka, N. Protonotarios, A. Vouliotis, A. Antonakopoulos, C. Ritsatos, D. Kotsas, C.H. Stefanadis (Athens and Naxos, GR) Long QT3 mice have disrupted sympathovagal balance and in vivo ventricular stimulation does not determine risk of sudden cardiac death, suggesting that a second perturbation may be required. – A. Opel, C. L-H Huang, A. Grace, A. Tinker (London and Cambridge, GB) The effect of corticosteroid, antiarrhythmic agents, and radiofrequency catheter ablation on ventricular tachycardia associated with cardiac sarcoidosis. – Y. Naruse, Y. Sekiguchi, H. Tada, T. Machino, K. Kuroki, H. Yamasaki, M. Igarashi, H. Okada, Y. Yamauchi, K. Aonuma (Tsukuba and Tokyo, JP) Outcome of patients with acute coronary syndromes complicated by ventricular tachycardia or fibrillation in the acute coronary syndromes istraeli survey (ACSIS). – K. Orvin, S. Gottlieb, I. Goldengerg, S. Matezki, G. Golovchiner, A. Battler, B. Strasberg, J. Kuznietz, M. Haim (Petah Tikva and Tel Aviv, IL) Changes in NT-proBNP level after successful PVC ablation in patients without structural heart disease: evidence for PVC-induced chronic wall stress. – C.F.B. Van Huls Van Taxis, D. Leong, S.R.D. Piers, A.P. Wijnmaalen, K. Dyrda, V. Delgado, A. Van Der Laarse, D.A. Pijnappels, M.J. Schalij, K. Zeppenfeld (Leiden, NL) The characteristics of malignant premature extrasystoles originating from right ventricular outflow tract. – A. Kasai, S. Sakabe, K. Mori, K. Miyagawa, K. Moriwaki, M. Sugimoto, T. Takamura, M. Horiguchi, A. Kawamura, T. Seko (Ise, JP) Effect of vagal nerve on the monophasic action potential of ventricular outflow tract. – D. Chang, L.J. Gao, S.L. Zhang, Y.L. Xia, Y.Z. Yang (Dalian, CN) Electromechanical coupling interval: a new marker of PVC in LV dysfunction. – M.E. Trucco, A. Berruezo, J. Fernandez-Armenta, D. Andreu, R. Borras, R. Evertz, J.M. Tolosana, E. Arbelo, L. Mont, J. Brugada (Barcelona, ES) Digitalis use and multivessel disease independently predict ventricular fibrillation at reperfusion in PCI-treated patients with ST-elevation myocardial infarction. – M.M. Demidova, J. Carlson, J.G. Smith, F. Holmqist, D. Erlinge, P.G. Platonov (Lund, SE) Electroanatomical substrate mapping guidance for left ventricle aneurysmectomy in patients after myocardial infarction. – P. Neuzil, J. Petru, S. Cerny, P. Pavel, J. Skoda, S. Kralovec, L. Plevkova, F. Holy, L. Sediva, V.Y. Reddy (Prague, CZ; New York, US) Increased spatial dispersion of the ventricular recovery time in patients with idiopathic ventricular fibrillation. – Y. Yazaki, Y. Goseki, Y. Saito, Y. Komatsu, A. Yamashina (Tokyo, JP) Predictors and prognosis of ventricular fibrillation during acute coronary syndromes. – C. Galvao Braga, V. Ramos, C. Vieira, J. Martins, S. Ribeiro, A. Gaspar, P. Azevedo, M.A. Pereira, S. Magalhaes, A. Correia (Braga, PT) Circulating biomarkers of extracellular matrix remodeling are associated with ventricular arrhythmia in heart failure patients. – K. Kelemen, J.L. Bermejo, P. Ellinghaus, T. Krahn, P. Lugenbiel, R. Becker, C. Zugck, A. Bauer, H.A. Katus, D. Thomas (Heidelberg and Wuppertal, DE) Efficacy of ICD therapy in high-risk children with Long QT syndrome. – R. Ildarova, M. Shkolnikova, V. Bereznitskaya, S. Termosesov (Moscow, RU) Takotsubo cardiomyopathy and arrhythmic risk. – F. Rotondi, F. Manganelli, F. Candelmo, T. Lanzillo, G. Stanco, F. Alfano (Avellino, IT) 244 P4083 P4084 P4085 P4086 P4087 (W) P4088 P4089 P4090 P4091 P4092 P4093 P4094 P4095 P4096 P4097 P4098 P4099 P4100 P4101 P4102 P4103 TUESDAY, 28 AUGUST 2012 – MORNING POSTERS J waves in the early recovery phase of acute myocardial infarction and its clinical implication. – M. Nakayama, H. Kitazawa, M. Sato, M. Okabe, A. Yamashina, Y. Aizawa (Nagaoka and Tokyo, JP) Amyloid deposition of intramural coronary arteries and peri-coronary neurons in epicardium may be the cause of ventricular arrhythmia in cardiac amyloidosis. – H. Yasui, H. Ishibashi-Ueda, Y. Ikeda, T. Matsuyama (Suita, JP) Prevalence of J wave and eraly repolarization pattern in a large population of aircrew members. – E. Perrier, S. Bisconte, D. Permal, O. Manen, J. Deroche, D. Dubourdieu, A.P. Hornez, J.F. Oliviez, V. Martel, P. Heno (Clamart, FR) P4104 P4105 P4106 ELECTROPHYSIOLOGIC STUDIES/SUDDEN CARDIAC DEATH P4107 P4108 P4109 P4110 P4111 P4112 P4113 P4114 P4115 P4116 P4117 P4118 TUESDAY – MORNING How do female electrophysiologists deal with radiation exposure during pregnancy: Results from the EPIC global survey. – S. Ernst, M.K. Chung, A. Russo, E. Hoffmann, S. Eisenberg, U. Birgesdotter-Green, C. Blomstroem-Lundquist, J. Poole (London, GB; Cleveland, Cherry Hill, Walnut Creek, San Diego and Seattle, US; Munich, DE; Uppsala, SE) Determinants of immediate intracardiac intervals prolongation after Percutaneous Aortic Valve Implantation. – J. Segura, J. Suarez De Lezo, F. Mazuelos, P. Martin, E. Caballero, M. Pan, M. Romero, S. Ojeda, J. Lopez Aguilera, A. Medina (Cordoba and Las Palmas, ES) Remote navigation and electroanatomical mapping with electromagnets: a validation human study. – J.L. Merino, Y. Shachar, A. Estrada, D. Doiny, S. Castrejon, D. Filgueiras, M. Ortega, J.A. Figueroa, E. Gang, J.L. Lopez Sendon (Madrid, ES; Inglewood and Los Angeles, US) Management of challenging transseptal access in patients with hypermobile septum/interatrial aneurysm or stiff septum/septal scaring. – C.I. Park, H. Lehrmann, R. Weber, J. Schiebeling, J. Stockinger, C. Herrera, T. Arentz, A. Jadidi (Bad Krozingen, DE) Epicardial electrophysiolosic mapping of ganglionated plexi for concomitant atrial fibrillation. – Y. Kondo, M. Ueda, M. Watanabe, T. Ishizaka, G. Matsumiya, Y. Kobayashi (Chiba, JP) Distribution of delayed potentials on the right ventricular endocardium in patients with late potentials on signal-averaged electrocardiograms due to arrhythmogenic right ventricular cardiomyopathy. – T. Kobayashi, S. Kamakura, K. Satomi, T. Noda, K. Miyamoto, Y. Yamada, H. Okamura, T. Aiba, S. Yasuda, W. Shimizu (Suita, JP) Radiation exposure during electrophysiology procedures: results from the EPIC global survey. – S. Ernst, M.K. Chung, A. Russo, E. Hoffmann, S. Eisenberg, U. Birgesdotter-Green, C. Blomstroem-Lundquist, J. Poole (London, GB; Cleveland, Cherry Hill, Walnut Creek, San Diego and Seattle, US; Munich, DE; Uppsala, SE) Mortality and morbidity after cavotricuspid isthmus radiofrequency catheter ablation for atrial flutter: outcomes from a controlled nonrandomized long-term study. – L. Fauchier, L. Desprets, N. Clementy, B. Pierre, B. Lallemand, I. Lagrenade, S. Taillandier, A. Bernard, D. Babuty (Tours, FR) Predictive value of programmed ventricular stimulation in ischemic cardiomyopathy and dilated cardiomyopathy patients with preserved systolic function. – D. Tsiachris, K.A. Gatzoulis, A. Vouliotis, P. Dilaveris, S. Sideris, P. Arsenos, I. Skiadas, I. Sotiropoulos, I. Kallikazaros, C. Stefanadis (Athens, GR) Use of Wearable Cardioverter Defibrillator after implantable cardioverter defibrillator explantation: clinical experience from 151 German patients. – C. Wan, H. Esser, S. Szymkiewicz (Pittsburgh, US) Return of spontaneous circulation after unwitnessed out-of-hospital cardiac arrest with asystole on initial rhythm. – Y. Goto, T. Maeda (Kanazawa and Komatsu, JP) Long-term follow-up and predictors of arrhythmic events in the brugada registry of the piedmont region of Italy. – N. Cerrato, C. Giustetto, A. Vairo, D. Giachino, L. Barbonaglia, F. Bianchi, G. Varalda, F. D’Ascenzo, P. Dalmasso, F. Gaita (Turin, Orbassano and Vercelli, IT) Initiative for strategic placement of AEDs in a city center increases coverage of cardiac arrest high-incidence areas. – C.M.H. Malta Hansen, M. Wissenberg, P. Weeke, M.H. Ruwald, F. Lippert, G.H. Gislason, S.L. Nielsen, L. Koeber, C. Torp-Pedersen, F. Folke (Copenhagen, DK) Electrocardiogram fails to identify high-risk individuals: analysis of a series of 50 sudden death cases. – M. Salar Alcaraz, P. Penafiel-Verdu, C. Munoz-Esparza, J.M. Lopez Ayala, C. Gonzalez Canovas, D. Lopez Cuenca, F. Escudero, F. Pastor Quirante, J.R. Gimeno Blanes, M. Valdes Chavarri (Murcia, ES) Association between an invasive strategy involving electrophysiologic study with prophylactic pacing and survival outcomes among adults with myotonic dystrophy type 1 and conduction system disease. – K. Wahbi, C. Meune, R. Porcher, H.M. Becane, A. Lazarus, P. Laforet, T. Stojkovic, A. Behin, B. Eymard, D. Duboc (Paris, FR) Cardiac conduction system involvement in patients with steinert’s myotonic dystrophy. – P.-G. Golzio, E. Pistone, T. Mongini, M. Morello, W. Grosso Marra, F. Gaita (Turin, IT) Significant incidence of sudden cardiac arrest under 55 with no better survival than older age groups. – R. Havmoller, K. Reinier, C. Teodorescu, A. Uy-Evanado, E. Stecker, H. Chugh, R. Mariani, K. Gunson, J. Jui, S.S. Chugh (Los Angeles and Portland, US) PCI during prolonged CPR: only patients with ventricular fibrillation benefit. – G. Simonis, J. Steglich, R.H. Strasser (Dresden, DE) P4119 P4120 P4121 P4122 P4123 P4124 245 TUESDAY, 28 AUGUST 2012 – MORNING POSTERS Circulating microRNAs after cardiac arrest. – Y. Devaux, E. Goretti, M. Vausort, L. Zhang, D.R. Wagner, P. Stammet (Luxembourg, LU) Impacts of rewarming speed differences on outcomes of therapeutic hypothermia in out-of-hospital cardiac arrest: is rapid rewarming efficient? – N. Kokubu, M. Hase, K. Tsuchihashi, J. Nishida, Y. Asai, N. Yonemoto, H. Yokoyama, K. Nagao, T. Miura, H. Nonogi (Sapporo, Tokyo, Suita, Osaka and Shizuoka, JP) Circadian variation in shockable heart rhythm and survival in out-of-hospital cardiac arrests. – F. Folke, C.M. Hansen, M.W. Joergensen, F.K. Lippert, S.L. Nielsen, G.H. Gislason, M.H. Ruwald, L. Koeber, C. Torp-Pedersen, P. Weeke (Copenhagen, DK) Cardiac screening of first-degree relatives after sudden cardiac death in young population. – B. Munoz-Calero, A. Recio Mayoral, F. Trujillo, M. Chaparro, L. Gonzalez-Torres, M.J. Valle-Caballero, M.J. Iglesias, R. Hidalgo, J.M. Cruz (Seville, ES) Risk factors for sudden cardiac death: Results from the Nordic arrhythmogenic right ventricular cardiomyopathy registry. – A.G. Holst, K.H. Haugaa, P.G. Platonov, T. Edvardsen, C. Lundin, T. Gilljam, O. Eschen, J. Hansen, H. Bundgaard, J.H. Svendsen (Copenhagen, Aalborg and Gentofte, DK; Oslo, NO; Lund and Gothenburg, SE) Survival from inpatient cardiac arrest in a referral hospital for cardiology and cardiac surgery. – P. Cokkinos, E. Papadopoulou, A. Gkouziouta, K. Farsalinos, V. Voudris, D.V. Cokkinos (Athens, GR) Long term prognosis and predictors of sudden cardiac death in patient with coronary spasm: single center cohort study. – J.S. Ko, N. Kim (Gwangju and Iksan, KR) Does adding up ventilation to chest compression modify memory retention when training general population to cardiopulmonary resuscitation? – P. Cassan, D. Zitouni, D. Meyran, E. Aliot, H. Hubert, J. Mansourati (Paris, Lille, Nancy and Brest, FR) ECG changes during hypothermia as potential markers of mortality of successfully resuscitated patients. – G. Apponyi, D. Pilecky, Z.S. Szelenyi, A. Horvath, S.Z. Szilagyi, K. Heltai, L. Geller, D. Becker, B. Merkely, E. Zima (Budapest, HU) Copeptin predicts neurological outcomes in out-of-hospital cardiac arrest survivors. – P. Ostadal, M. Prucha, A. Kruger, D. Vondrakova, M. Janotka (Prague, CZ) Survivors of sudden cardiac death with depression are not at significantly greater risk of recurrent arrhythmias and death. – M. Turagam, P. Velagapudi, A. Szabo, A. Visotcky, A. Kocheril (Madison, Milwaukee and Urbana, US) Detection of pulseless electrical activity by a public access defibrillator using ECG and ICG. – C. Navarro, N. Cromie, O. Escalona, R. Di Maio, A. Howe, A.I. Thompson, J. Anderson (Belfast, Jordanstown and Craigavon, GB) Analysis of the relation between T-wave alternans and myocardial ischemia diagnosed by gated-SPECT: results of the SPECTACLE study. – C. Radig Lambert, C. Cohen, C. Goetz, W. Kaiser, M.C. Perier, F. Zores, G. Roul (Colmar, Strasbourg and Paris, FR; Freiburg, DE) Improved prognosis after implementation of chest compression device in out-of-hospital cardiac arrest. – S.N. Morozov, S.N. Abdusalamov, A.Y. Fedorov (Moscow and Yakutsk, RU) Normal limits of the adult electrocardiogram for ages 16-90 years. – P.R. Rijnbeek, G. Van Herpen, M.L. Bots, C.A. Swenne, N. Verweij, J.C.M. Witteman, J.A. Kors (Rotterdam, Utrecht, Leiden and Groningen, NL) First validation of esophageal long-term electrocardiography as an alternative technique for long-term heart rhythm monitoring. – A. Haeberlin, T. Niederhauser, T. Marisa, J. Goette, M. Jacomet, H. Tanner, J. Fuhrer, R. Vogel (Bern and Solothurn, CH) Relationship of fragmented QRS and delayed contrast enhanced cardiovascular magnetic resonance (DE-CMR) imaging in patients with myocardial infarction. – M.-S. Ahn, Y.B.S. Yoo, L.J.W. Lee, L.J.H. Lee, Y.Y.J. Youn, A.J.G. Ahn, K.J.Y. Kim, L.S.H. Lee, Y.J.H. Yoon, C.K.H. Choe (Wonju, KR) Frontal plane ST-segment and QRS complex abnormalities as predictors of extent of necrosis and left ventricular dysfunction assessed by 3 Tesla cardiac MR. – C.A. Ingino, G.A. Rodriguez-Granillo, F. Lopez, R. Borracci, J. Pulido, M. Archer, L. Celano, P. Lylyk (Buenos Aires, AR) A left-to-right interatrial frequency gradient during atrial fibrillation can be detected using standard 12-lead ECG. – F. Holmqvist, I. Nault, J. Carlson, M. Hocini, M. Haissaguerre, P.G. Platonov (Lund, SE; Bordeaux-Pessac, FR) Epicardial cooling increases opportunity of spiral wave termination: a simulation study. – S. Inada, T. Ashihara, R. Haraguchi, T. Arafune, I. Sakuma, M. Yamazaki, H. Honjo, I. Kodama, K. Nakazawa (Suita, Osaka, Otsu, Tokyo and Nagoya, JP) Role of new task force ECG criteria in the diagnosis of arrhythmogenic right ventricular dysplasia/cardiomyopathy. – J.M. Rubio Campal, J. Benezet-Mazuecos, P. Sanchez-Borque, M.A. Quinones, S. Del Castillo, E. Macia, H.P. Gaebelt, J. Hernandez, A. Lopez, J. Farre (Madrid, ES) Role of home monitoring in effective device management of patients with implantable cardioverter-defibrillators: a prospective randomized trial. – O. Osmera, A. Bulava (Ceske Budejovice, CZ) 246 P4125 P4126 P4127 P4128 P4129 P4130 P4131 (W) P4132 P4133 P4134 P4135 P4136 P4137 P4138 P4139 P4140 P4141 P4142 P4143 P4144 P4145 P4146 TUESDAY, 28 AUGUST 2012 – MORNING POSTERS IN-STENT-RESTENOSIS AND INVASIVE CORONARY IMAGING P4147 P4148 P4149 P4150 P4151 P4152 P4153 P4154 P4155 P4156 P4157 P4158 P4159 P4160 P4161 P4162 TUESDAY – MORNING Higher stroke rate in patients undergoing elective PCI for in-stent-stenosis in clinical practice in Europe: results of the EHS PCI registry. – A.K. Gitt, T.I.M.M. Bauer, R. Zahn, M. Hochadel, U. Zeymer, C. Hamm (Ludwigshafen and Bad Nauheim, DE) The optimal strategy for restenosis with stent fracture after drug-eluting stent implantation: 1st generation DES vs. 2nd generation DES. – S. Otsuru, K. Kadota, D. Hasegawa, S. Habara, T. Tada, H. Tanaka, Y. Fuku, N. Oka, T. Goto, K. Mitsudo (Kurashiki, JP) Coronary flow velocity and fluid shear stress predict late catch-up after sirolimus-eluting stent implantation. – H. Hikita, S. Kuroda, Y. Oosaka, N. Kawaguchi, D. Akiyama, T. Sugiyama, T. Kamiishi, S. Kimura, A. Takahashi, M. Isobe (Yokosuka and Tokyo, JP) Virtual histology intravasucular ultrasound comparison of neointimal morphology of in-stent restenosis with drug eluting stents versus bare metal stents. – S. Fujita, S. Sakuragi (Iwakuni, JP) Predictors of neointima hyperplasia in in-stent restenosis. – M. Popovici, I. Popovici, S. Kostin, V. Cobet, V. Ivanov, N. Ciobanu, L. Ciobanu (Chisinau, MD) Difference in clinical restenosis rates between silicon carbide and uncoated bare metal stents. – S. Haine, B. Cornez, J. Jacobs, H. Miljoen, M. Claeys, T. Vandendriessche, J. Bosmans, C. Vrints (Antwerp, BE) Changes in early cardiac gene transcript levels in peripheral blood mononuclear cells after percutaneous coronary intervention and their relationship to restenosis. – J.E. Kontaraki, G.E. Kochiadakis, M.E. Marketou, N.E. Igoumenidis, P.E. Vardas (Heraklion, GR) No harmful effect of stem cell mobilization by granulocyte-colony stimulating factor on restenosis or late luminal loss after sirolimus-eluting stent implantation. – Y. Iwata, Y. Fujimoto, T. Kadohira, T. Morino, K. Ohkubo, K. Sugimoto, E. Ichimoto, K. Kubo, T. Miyayama, Y. Kobayashi (Chiba, JP) Comparison of mid-term angiographical outcomes of drug-eluting stents in hemodialysis patients. – Y. Fuku, K. Mitsudo, K. Kadota, T. Goto, N. Oka, H. Tanaka, T. Tada, S. Habara, Y. Shigemoto, D. Hasegawa (Kurashiki, JP) Severe insulin resistance is a predictor of restenosis after drug-eluting stent implantation. – T. Yufu (Koshigaya, JP) Mobilization of CD34+KDR+ cells among circulating progenitors predicts bare-metal stent restenosis. – L. Bonello, K.H. Harhouri, K.B. Baumstarck, L.A. Arnaud, N.L. Lesavre, C.P. Piot, F.P. Paganelli, F.D.G. Dignat-George, F. Sabatier (Marseille and Montpellier, FR) Correlation between hs-CRP and genetic polymorphism in in-stent-restenosis after bare metal stenting. – M. Chinikar, P. Sadeghipour, S. Javadi, S. Rafati, A. Heidarzadeh, S. Hoda, Y. Taslimi, H. Esmaili (Rasht and Tehran, IR) Impaired production of anti-atherosclerotic interleukin-10 by macrophage within culprit coronary plaque in diabetic patients with restenosis after primary PCI. – T. Kameyama, T. Sato, T. Noto, T. Nakadate, H. Ueno, K. Yamada, H. Inoue (Toyama, Takaoka, Imizu and Uodu, JP) Reseeding of a decellularized arterial matrix for restenosis research. – D. Haase, S. Otto, B.F.M. Romeike, H.-R. Figulla, T.C. Poerner (Jena, DE) Tissue characteristics in in-stent restenosis lesions after various drug-eluting stents and bare-metal stent assessing with optical coherence tomography. – T. Tada, K. Kadota, S. Habara, H. Tanaka, Y. Fuku, N. Oka, H. Katoh, H. Yamamoto, T. Goto, K. Mitsudo (Kurashiki, JP) Comparison of neointimal tissue characteristics among bare-metal stent, paclitaxel-eluting stents and zotarolims-eluting stents using integrated-backscatter intravascular ultrasound. – K. Kashiyama, S. Sonoda, R. Anai, Y. Muraoka, F. Kamezaki, Y. Tsuda, M. Araki, M. Okazaki, Y. Otsuji (Kitakyushu, JP) Spatial distribution of culprit lesion thin cap fibroatheromas and culprit ruptured plaques in acute coronary syndrome. An optical coherence tomography study. – A. Karanasos, K. Toutouzas, M. Riga, E. Tsiamis, A. Synetos, K. Stathogiannis, A. Papanikolaou, G. Triantafyllou, D. Tousoulis, C. Stefanadis (Athens, GR) Optical coherence tomography guided angioplasty during acute coronary syndrome: the OTOCLAV study. – P. Motreff, N. Amabile, G. Souteyrand, N. Combaret, R. Hamdan, S. Ghostine, C. Caussin (Clermont-Ferrand and Le Plessis-Robinson, FR) Relationship between optical coherence tomography (OCT), intravascular ultrasound tomography (IVUS) and pressure-derived fractional flow reserve. – T. Osue, J. Shite, T. Shinke, H. Otake, K. Hirata (Kobe, JP) VH-IVUS predictors for lesion specific myocardial ischemia in intermediate coronary artery stenosis. – J.H. Doh, B.K. Koo, C.W. Nam, S.Y. Lee, H. Choe, J.H. Kim, H.S. Kim, S.W. Hong (Goyang, Seoul and Daegu, KR) Intravascular ultrasound-guided treatment for intermediate left main coronary lesions. – S. Golebiewski, A.I. Gziut, T. Kulawik, P. Kwiatkowski, Z. Sliwinski, J. Rzezak, T. Pawlowski, D. Vassilev, R.J. Gil (Warsaw, PL; Sofia, BG) P4163 P4164 P4165 P4166 P4167 247 TUESDAY, 28 AUGUST 2012 – MORNING POSTERS NON CORONARY AND TAVI INTERVENTIONS Percutaneous occlusion of left atrial appendage with the amplatzer cardiac plug: results from clinical, echocardiographic and CT follow-up in 100 implanted patients. – G. Santoro, S. Berti, F. Meucci, C. Palmieri, U. Paradossi, G. Squillantini, G. Rosso, F. Mori, A. Oddo (Florence and Massa, IT) Comparative analysis of percutaneous left atrial appendage (LAA) closure systems: a single center experience. – M. Kulikoglu, S. Bordignon, V. Urban, M. Gunawardene, B. Schulte-Hahn, B. Nowak, B. Schmidt, K.R.J. Chun (Frankfurt, DE) Refining transcatheter left atrial appendage closure: eliminating the anaesthestist and reducing the cost. – D.F. Waterhouse, S.D. Asgedom, A. Neylon, M. Alqaseer, B. Mcadam, D.P. Foley (Dublin, IE) The role of intracardiac echocardiography in the management of left atrial appendage occlusion: three years experience. – S. Berti, G. Santoro, G. Rosso, F. Meucci, A. Viggiano, U. Paradossi, C. Palmieri (Massa and Florence, IT) Left atrial appendage occlusion: the link between imaging techniques and clinical events. – A. Viggiano, U. Paradossi, C. Palmieri, A. De Caterina, A. Clemente, E. Cerone, S. Berti (Massa, IT) Atrial arrhythmias after implantation of atrial septal defect devises. Is there an inflammatory component? – M. Vavouranakis, C. Kavouras, I. Vlaseros, K. Aggeli, I. Felekos, D. Vrachatis, K. Kalogeras, S. Georgiou, I. Kalikazaros, C. Stefanadis (Athens, GR) “Migraine side effect” after PFO closure as secondary prevention of stroke or TIA. – M. Kumor, E.K. Biernacka, M. Jagodzinska, A. Platek, M. Demkow, W. Ruzyllo, M. Konka, P. Hoffman (Warsaw, PL) Transthoracic echocardiography guidance during percutaneous closure of patent foramen ovale. – U. Canpolat, K. Aytemir, H. Yorgun, H. Sunman, M. Dural, L. Sahiner, E.B. Kaya, G. Kabakci, L. Tokgozoglu, A. Oto (Ankara and Kayseri, TR) Simultaneous measurement of left ventricular volume and pressure during percutaneous mitral valve repair with the evalve mitraclipTM system. – O. Gaemperli, P. Biaggi, M. Osranek, C. Felix, D. Bettex, J. Grunenfelder, V. Falk, T.F. Luscher, R. Corti (Zurich, CH) Impact of mitral annulus dimensions assessed by 3D echocardiography on procedural results of percutaneous edge-to-edge mitral valve repair and left atrial and left ventricular reversed remodeling. – E. Altiok, S. Hamada, K. Brehmer, S. Reith, M. Becker, J. Schroeder, M. Almalla, N. Marx, R. Hoffmann (Aachen, DE) Mitral Valvuloplasty long-term follow-up of single balloon (Balt) versus Inoue balloon techniques. – I.P. Borges, E.C.S. Peixoto, R.T.S. Peixoto, R.T.S. Peixoto (Rio de Janeiro, BR) Percutaneous mitral balloon valvuloplasty beyond 65 years of age. – Z. Chmielak, M. Klopotowski, M. Demkow, M. Konka, P. Hoffman, K. Kukula, M. Kruk, A. Witkowski, W. Ruzyllo (Warsaw, PL) Clinical and echocardiographic outcomes of patients undergoing percutaneous closure of mitral paravalvular leak:. – S. Valbuena Lopez, J. Ruiz Garcia, P. Salinas Sanguino, R. Moreno, S. Jimenez-Valero, G. Galeote, A. Sanchez-Recalde, L. Calvo Orbe, M. Moreno, J. Lopez-Sendon (Madrid, ES) Percutaneous balloon mitral commissurotomy during pregnancy: Our Experience. – A. Tounsi, L. Abid, D. Abid, S. Mallek, M. Akrout, F. Triki, M. Hentati, S. Kammoun (Sfax, TN) Endovascular stenting for palliation in malignant superior vena cava syndrome. – K. Lang, M. Ulrich, S. Braeunlich, A. Schmidt, S. Guetz, S. Botsios, D. Scheinert (Eggenfelden and Leipzig, DE) Impact of iso-osmolar versus low-osmolar contrast agents on contrast-induced acute kidney injury in unselected patients undergoing transcatheter aortic valve implantation. – K.C. Chatani, A.M. Abdel-Wahab, R.T. Toelg, V.G. Geist, M.M. Marwan, A.M. Mostafa, G.R. Richardt (BadSegeberg, DE) Impact of percutaneous treatment of acute pulmonary embolism in intermediate and high risk patients. – N. Farre, F. Miranda, M. Orozco-Levi, N. Salvatella, H. Tizon, L. Molina, J. Gea, J. Bruguera (Barcelona, ES) Three dimensional rotational angiography fused with multimodal imaging modalities offers a novel, accurate, fast and safe way to guide endomyocardial injections. – D. Dauwe, D. Nuyens, S. De Buck, P. Claus, L. Janssens, W. Coudyzer, O. Gheysens, M. Koole, H. Heidbuchel, S. Janssens (Leuven, BE) Transcatheter closure of ruptured sinus of valsalva aneurysm with nitinol mesh occluders. – J. Bialkowski, M. Szkutnik (Zabrze, PL) Arrhythmia device lead extraction using evolution mechanical dilator sheath. – U. Canpolat, K. Aytemir, H. Yorgun, H. Sunman, L. Sahiner, K.M. Gurses, E.B. Kaya, G. Kabakci, L. Tokgozoglu, A. Oto (Ankara and Kayseri, TR) Comparison of knowledge-based weaning (KBW) and physician-driven weaning of mechanically ventilated patients in the coronary care unit. – E.T.S. Lim, N. Hamid, N.C. Beh, G.C. Phua, J. Tan (Singapore, SG) P4168 P4169 P4170 P4171 P4172 P4173 P4174 P4175 P4176 P4177 P4178 P4179 P4180 P4181 P4182 P4183 (W) P4184 P4185 P4186 P4187 P4188 TAVI EXPERIENCE Predictors and clinical outcome of significant paravalvular aortic regurgitation following transcatheter aortic valve implantation. – E.M.A. Wiegerinck, Z.Y. Yong, K. Boerlage-Van Dijk, K.T. Koch, M.M. Vis, B.J. Bouma, R. Cocchieri, J.J. Piek, B.A.J.M. De Mol, J. Baan (Amsterdam, NL) 248 P4189 TUESDAY, 28 AUGUST 2012 – MORNING POSTERS P4190 P4191 P4192 P4193 P4194 P4195 P4196 P4197 P4198 P4199 P4200 P4201 P4202 P4203 P4204 P4205 TUESDAY – MORNING Incidence and intraprocedural management of aortic regurgitation in interventional aortic valve replacement. – M. Fueller, G. Bodman, E. Kilger, R. Sodian, M. Block (Munich, DE) Under-deployment and asymmetrical expansion in transcatheter aortic valves. – R. Cadenas Chamorro, P. Salinas, R. Moreno, L. Calvo, S. Jimenez-Valero, A. Sanchez-Recalde, G. Galeote, A.M. Iniesta, I. Plaza, J.L. Lopez-Sendon (Madrid, ES) Prosthesis/annulus discongruence by three-dimensional transesophageal echocardiography: predictor of significant aortic regurgitation after transcatheter aortic valve implantation. – N. Santos, C. Olmos, J.A. De Agustin Loeches, P. Marcos-Alberca, C. Fernandez-Golfin, C. Almeria, J.L. Rodrigo, J. Zamorano, C. Macaya, L. Perez De Isla (Madrid, ES) Clinical and hemodynamic outcomes in patients with prosthesis-patient mismatch after TAVI with both core valve and edwards sapien XT valves. – K. Stathogiannis, K. Toutouzas, K. Spargias, G. Latsios, A. Synetos, A. Karanasos, M. Chrissoheris, A. Antoniadis, G. Pavlides, C. Stefanadis (Athens, GR) Predictors of prosthesis-patient mismatch in patients undergoing TAVI with CoreValve and Sapien XT. – K. Stathogiannis, K. Toutouzas, K. Spargias, G. Latsios, A. Synetos, A. Karanasos, M. Chrissoheris, A. Antoniadis, G. Pavlides, C. Stefanadis (Athens, GR) Impact of valve type and annular size on post TAVI aortic valve regurgitation. – K. Stathogiannis, K. Toutouzas, K. Spargias, G. Latsios, A. Synetos, A. Karanasos, M. Chrissoheris, A. Antoniadis, G. Pavlides, C. Stefanadis (Athens, GR) Relation of Aortic Regurgitation (AR) to Plasma Brain Natriuretic Peptide (BNP) evolution after Transfemoral Aortic Valve Implantation (TAVI) for Severe Aortic Stenosis (AS). – K. El Chilali, T. Konorza, F. Al Rashid, P. Patsalis, B. Plicht, D. Wendt, M. Thielmann, H. Jakob, R. Erbel, P. Kahlert (Essen, DE) Optimazing vascular access during TAVI by using inferior epigastric artery as a landmark. – M. Vavuranakis, K. Kalogeras, D. Vrachatis, M. Kariori, K. Aznaouridis, C. Moldovan, K. Masoura, G. Lazaros, E. Gravia, C. Stefanadis (Athens, GR) Effect of transfemoral aortic valve implantaion (TF-AVI) for severe aortic stenosis on plasma brain natriuretic peptide (BNP) levels: predictive value for 30-days and 1-year survival. – K. El Chilali, T. Konorza, F. Al Rashid, P. Patsalis, B. Plicht, D. Wendt, M. Thielmann, H. Jakob, R. Erbel, P. Kahlert (Essen, DE) Incidence and prognostic implications of the subclavian approach for Transcatheter aortic valve implantation with the CoreValve prosthesis. – A.J. Munoz Garcia, M.J. Molina Mora, E. Munoz Garcia, M.F. Jimenez Navarro, A.J. Dominguez Franco, J.H. Alonso Briales, M. Such Martinez, J.M. Hernandez Garcia, E. De Teresa Galvan (Malaga, ES) Decrease in sheath size for transfemoral Aortic Valve Implantation: what are the consequences? – C. Tron, B. Borz, M. Godin, A. Canville, C. Hauville, P.-Y. Litzler, J.-P. Bessou, A. Cribier, H. Eltchaninoff (Rouen, FR) Lower pacing rate with CoreValve TAVI: high implantation or Accutrak catheter, or both? – M. Drury-Smith, S. Lakshmanan, R. Giri, M. Fayaz, J. Cotton, M. Bhabra, S. Khogali (Wolverhampton, GB) Hybrid endovascular repair for aortic arch pathology: intermediate outcomes and complications. – W.C. Kang, E.K. Shin, C.H. Park, J.M. Kang, Y.G. Ko, D.H. Choi, Y.N. Youn, W.H. Shim (Incheon, Seoul and Bucheon, KR) Incidence, predictive factors and prognostic value of inflammatory reaction following tanscatheter aortic valve implantation (TAVI). – Y. Maazoun, C. Martinez, M. Radermecker, J. Magne, R. Durieux, O. Gach, L. Davin, J. Defraigne, V. Legrand (Liège, BE) Early changes of left ventricle deformation indices after transcatheter aortic valve implantation. A speckle tracking echocardiographic study. – M. Vavuranakis, I. Vlasseros, K. Kalogeras, M. Kariori, D. Vrachatis, C. Moldovan, V. Katsi, R. Katsarou, I. Kallikazaros, C. Stefanadis (Athens, GR) Mitral regurgitation after transcatheter aortic valve implantation with the Medtronic-CoreValve prosthesis impairs survival. – K. Boerlage-Van Dijk, E.M.A. Wiegerinck, Z.Y. Yong, B.J. Bouma, M.M. Vis, K.T. Koch, R. Cocchieri, J.J. Piek, J. Baan (Amsterdam, NL) Incidence, predictors and impact of bleeding after transcatheter aortic valve implantation. – B. Borz, E. Durand, M. Godin, C. Tron, P.-Y. Litzler, J.-P. Bessou, A. Canville, A. Cribier, H. Eltchaninoff (Rouen and Paris, FR) Renal outcome after transcatheter aortic valve implantation. – R. Schnabel, M. Seiffert, S. Wilde, P. Diemert, J. Schirmer, L. Conradi, H. Reichenspurner, S. Blankenberg, H. Treede, S. Baldus (Hamburg, DE) Predictors of mortality post balloon aortic valvulplasty, results from the BRAVO registry. – J. Yu, A. Kini, M.G. Cohen, U. Baber, S. Sartori, R. Mehran, G. Vlachojannis, B. O’Neill, S. Sharma, G.D. Dangas (New York and Miami, US) Off-label indications for trans-catheter aortic valve implantation. – A. Segev, D. Spiegelstein, P. Fefer, A. Shinfeld, I. Hay, E. Raanani, V. Guetta (Tel Aviv, IL) Incidence and predictors of combined safety endpoints occurrence after transcatheter Sapien XT and CoreValve implantation. A single Centre experience. – S. Cassese, A.M. Kasel, A.W. Leber, D. Antoni, G. Riess, A. Hutter, J. Vogel, A. Kastrati, W. Eichinger, E. Hoffmann (Munich, DE) P4206 P4207 P4208 P4209 P4210 249 TUESDAY, 28 AUGUST 2012 – MORNING POSTERS MYOCARDIAL FUNCTION LEFT VENTRICULAR DEFORMATION Impact of acute normobaric hypoxia on regional and global myocardial function: a speckle tracking echocardiography study. – B. Goebel, V. Handrick, A. Lauten, M. Fritzenwanger, J. Schuetze, S. Otto, H.R. Figulla, T. Edvardsen, T.C. Poerner, C. Jung (Jena, DE; Oslo, NO) Inhibition of Interleukin-1 activity by anakinra improves left ventricular myocardial deformation and torsion in patients with CAD and coexistent rheumatoid arthritis: a randomized trial. – I. Ikonomidis, S. Tzortzis, I. Andreadou, P. Dasou, C. Katseli, P. Katsimbri, I. Paraskevaidis, J. Parissis, J. Lekakis, M. Anastasiou-Nana (Athens, GR) Prognostic significance of speckle tracking-derived myocardial function in multivesel coronary disease. – P. Zycinski, K. Wierzbowska-Drabik, H. Qawoq, P. Szczesniak, L. Chrzanowski, J.D. Kasprzak (Lodz, PL) Left ventricular rotation and torsion and its relation to functional capacity in hypertensive patients. – A. Majstorovic, V. Celic, B. Pencic-Popovic, A. Sljivic, B. Stojcevski, A. Andric, I. Ilic-Djordjevic, S. Backovic, M. Pavlovic-Kleut (Belgrade, RS) Correlation of area strain by three-dimensional speckle tracking echocardiography with exercise capacity in subjects undergoing treadmill exercise test. – W.-C. Tsai, Y.-W. Liu, J.-Y. Shih, Y.-S. Huang, W.-H. Li, L.-M. Tsai (Tainan and Douliou City, TW) Chronic and acute smoking-induced impairment in longitudinal myocardial function: a strain-imaging study in healthy young smokers. – K. Farsalinos, D. Tsiapras, S. Kyrzopoulos, E. Avramidou, D. Vassilopoulou, V. Voudris (Athens, GR) Two-dimensional Speckle-tracking Echocardiography to Identify reversible myocardial dysfunction. – M. Orii, K. Hirata, K. Ishibashi, T. Yamano, T. Tanimoto, Y. Ino, T. Yamaguchi, T. Kubo, T. Imanishi, T. Akasaka (Wakayama, JP) Soluble angiotensin converting enzyme is linked with impaired myocardial deformation and torsion in untreated hypertensives. – I. Ikonomidis, A. Tsantes, H. Triantafyllidi, S. Tzortzis, P. Trivilou, I. Paraskevaidis, C. Papadopoulos, A. Travlou, J. Lekakis, M. Anastasiou-Nana (Athens, GR) Evaluation of left ventricular segmental strain by three-dimensional echocardiography. – A. Muranaka, S. Yuda, M. Kawamukai, H. Kouzu, H. Akasaka, H. Ohnishi, A. Hashimoto, S. Saitoh, K. Tsuchihashi, T. Miura (Sapporo, JP) Impaired LV systolic function in asymptomatic lean individuals with obstructive sleep apnoea evidenced by speckle-tracking echocardiography. – H.Q. Pham, S.K. Namtvedt, H. Rosjo, T. Omland, K. Steine, T.G. Von Lueder (Lørenskog, NO) Assessment of left ventricular myocardial deformation and mechanical dyssynchrony in patients with heart failure: insights from three-dimensional wall motion analysis. – X.X. Luo, F. Fang, A.P. Lee, Y.Y. Lam, J.E. Sanderson, J.S.W. Kwong, C.M. Yu (Hong Kong, CN) Normal area strain values by three dimensional speckle tracking echocardiography in the first year post-heart transplantation in the absence of acute cellular rejection. – M. Ruiz Ortiz, D. Mesa, M. Delgado, E. Romo, F. Castillo, M.C. Morenate, C. Leon, A. Lopez Granados, J.M. Arizon Del Prado, J. Suarez De Lezo (Cordoba, ES) Area strain for the assessment of regional left ventricular wall thickening using 3D Speckle Tracking. – S.F. De Marchi, S. Urheim, E.W. Remme, R. Massey, S. Aakhus (Oslo, NO) Diabetic retinopathy is associated with the occurrence of subclinical diabetic cardiomyopathy in patients with type II diabetes. – C.T. Zhao, M. Wang, K.H. Yiu, H.F. Tse (Hong Kong, HK) Ejection fraction and deformation in response to three different chemotoxic regimens. – T. Negishi, K. Negishi, D. Agler, B. Haluska, J.C. Plana, T. Marwick (Cleveland, US; Brisbane, AU) Left ventricular dyssynchrony in patients with microvascular obstruction after primary percutaneus coronary intervention evaluated with Real-time 3D speckle tracking echocardiography. – G. Pinnacchio, L. Barone, A. Stazi, I. Battipaglia, L. Marinaccio, M. Laurito, I. Coviello, A. Sestito, G.A. Lanza, F. Crea (Rome, IT) The dangerous liaison between left ventricular systolic function and mitral annulus calcification in patients with type 2 diabetes without myocardial ischemia. Data from SHORTWAVE study. – G. Faganello, S. De Feo, N. Berlinghieri, P. Faggiano, R. Candido, C. Mazzone, A. Di Lenarda, B. Pinamonti, L. Tarantini, G. Cioffi (Trieste, Trento, Peschiera del Garda and Belluno, IT) Effects of radiotherapy on right and left heart function in patients with left-sided breast and lung cancer detected by strain and strain rate imaging. – B. Cakal, S. Cakal, A. Mayadagli, K. Ekici, Z. Bayram, M.O. Gursoy, R.D. Acar, N.E. Duran, M. Yildiz, M. Ozkan (Istanbul, TR) Reduced left ventricular contractility with electrical dyssynchrony increases the dyscoordination by speckle tracking strain rate analysis. – T. Omuro, T. Maruo, S. Eguchi, Y. Yamanouchi, A. Kurihara, H. Chikuji, S. Fujii, K. Kadota, K. Mitsudo (Kurashiki, JP) Effect of left ventricular twisting for the accuracy of two-dimensional longitudinal strain analysis. – M. Takeuchi, K. Otani, M. Iwataki, H. Kuwaki, K. Kaku, N. Haruki, H. Yoshitani, Y. Otsuji (Kitakyushu, JP) Assessment of left ventricular dyssynchrony with real time 4D ultrasound system: comparison with Doppler Myocardial Imaging. – A.R. Martiniello, P. Caso, M. Cavallaro, C. Cioppa, I. Caso, G. Tonti, R. Calabro’ (Naples and Campobasso, IT) 250 P4211 P4212 P4213 P4214 P4215 P4216 P4217 P4218 P4219 P4220 P4221 P4222 P4223 P4224 P4225 P4226 P4227 P4228 P4229 P4230 P4231 TUESDAY, 28 AUGUST 2012 – MORNING POSTERS MYOCARDIAL FUNCTION “DIASTOLOGY” Brain natriuretic peptide is independently associated with indices of left ventricular filling pressure but not with left ventricular mass in asymptomatic individuals. – N.S. Chahal, T.K. Lim, P. Jain, D. Gaze, J. Chambers, J. Kooner, P. Collinson, R. Senior (London and Harrow, GB) Decreased velocity propagation of the left ventricle is associated with increased arterial stiffness. – E. Chatzistamatiou, G. Trantalis, G. Moustakas, I. Skiadas, I. Babatseva-Vagena, N. Kalovidouris, C. Liakos, A. Avgeropoulou, C. Stefanadis, I. Kallikazaros (Athens, GR) The E-wave deceleration rate E/DT but not the tissue-Doppler derived index E/Ea reliably characterizes pressure-overload induced diastolic dysfunction. – T.D. Nguyen, Y. Shingu, M. Schwarzer, A. Schrepper, T. Doenst (Jena and Leipzig, DE) 3D echocardiography facing the challenge of diastolic function evaluation. – A. Goncalves, C. Sousa, I. Rangel, A.S. Correia, F. Macedo, J.L. Zamorano, M.J. Maciel (Porto, PT; Madrid, ES) Diagnostic value of exercise E/E’ ratio for the early detection of diastolic heart failure in non-obstructive HCM patients. – D. Zhu, G.D. Ma, X.H. Feng, Y.Z. Zhang, Z.P. Li, W. Gao (Beijing, CN) Presence of preoperative diastolic dysfunction predicts postoperative pulmonary edema in patients undergoing major noncardiac surgery. – D. Cho, S.A. Kim, M.N. Kim, Y.H. Kim, S.M. Park, H.J. Lim, W.J. Shim (Seoul, KR) Diastolic tissue doppler velocities predicts adverse outcome after st-elevation myocardial infarction treated with primary percutaneous coronary intervention. – T. Biering-Sorensen, P. Sogaard, R. Mogelvang, S.H. Pedersen, S. Lindberg, S. Galatius, S. Hoffmann, J.S. Jensen (Copenhagen, DK) Myocardial performance index determined by tissue doppler imaging m-mode predicts outcome in patients with st-elevation myocardial infarction treated with primary percutaneous coronary intervention. – T. Biering-Sorensen, R. Mogelvang, S.H. Pedersen, P. Sogaard, S. Galatius, J.S. Jensen (Copenhagen, DK) Exercise left ventricular filling pressure: prognostic implications in patients after acute myocardial infarction. – M. Deljanin Ilic, S. Ilic, V. Stoickov, D. Kalimanovska Ostric, V. Ilic (Niska Banja and Belgrade, RS) Diastolic but not systolic function is associated with coronary flow reserve in chronic heart failure patents. – M. Snoer, T. Monk-Hansen, R. Olsen, L. Pedersen, H. Rasmusen, F. Dela, E. Prescott (Copenhagen, DK) Association between Eas index by tissue Doppler imaging and ventricular stiffness index or ventriculoarterial interaction in patients with preserved left ventricular ejection fraction. – H. Sako, S. Miura, S. Furuyama, A. Matsunaga, K. Saku (Fukuoka, JP) P4232 P4233 P4234 P4235 P4236 P4237 P4238 P4239 P4240 P4241 P4242 MYOCARDIAL FUNCTION “ISCHEMIC CARDIOMYOPATHY” P4243 P4244 P4245 P4246 P4247 TUESDAY – MORNING The prognostic role of dobutamine stress contrast echo in patients with known or suspected coronary artery disease in different age groups. – C. Aggeli, I. Felekos, P. Stergiou, E. Poulidakis, A. Katsaros, E. Sfendouraki, G. Roussakis, C. Stefanadis (Athens, GR) Stress-echocardiography to identify restenosis in drug eluting stent patients. – S. Calcagno, M. Pagliaro, L. Lucisano, M. Pennacchi, N. Bruno, A. D’Ambrosi, M. Mancone, G. Sardella, F. Fedele (Rome, IT) End-systolic pressure-volume relation and ventricular-arterial coupling predict cardiac events in patients with negative stress echocardiography. – T. Bombardini, R. Sicari, Q. Ciampi, S. Gherardi, L. Pratali, E. Picano (Pisa, Benevento and Cesena, IT) Feasibility, symptoms, adverse effects and complications associated with non invasive assessment of coronary flow velocity in women with suspected or known coronary artery disease. Experience in 1455. – R. Montisci, M. Ruscazio, N. Zedda, C. Soro, L. Sau, F. Tuveri, L. Meloni (Cagliari, IT) Gender difference of diagnostic utility of dobutamine stress echocardiography with early atropine administration in detection of coronary artery disease. – K. Wierzbowska-Drabik, N. Roszczyk, M. Sobczak, P. Lipiec, L. Chrzanowski, J.Z. Peruga, R. Krecki, M. Plewka, J.D. Kasprzak (Lodz, PL) Coronary flow velocity reserve in 3 major coronary arteries can be a promising alternative for fractional flow reserve in determining hemodynamic significance of coronary artery disease. – T. Wada, K.H. Hirata, K. Ishibashi, T. Yamano, T. Tanimoto, Y. Ino, T. Yamaguchi, T. Kubo, T. Imanishi, T. Akasaka (Wakayama, JP) Higher prevalence of carotid disease compared to myocardial ischaemia in patients undergoing simultaneous stress echocardiography for suspected coronary artery disease. – S. Ahmadvazir, C. Kinsey, K. Zacharias, J. Pabla, B. Shah, R. Senior (Harrow and London, GB) Left ventricular torsion during exercise in patients with and without ischemia in the left anterior descending coronary artery territory. – J. Peteiro, A. Bouzas-Mosquera, A. Lopez-Sainz, M. Lopez-Perez, G. Barge-Caballero, O. Prada, A. Castro-Beiras (A Coruña, ES) Abnormal stress electrocardiography in the presence of normal stress echocardiography. – M. Patchett, R. Wilkof, A. Vodonos, N. Liel-Cohen, V. Novack, S. Kobal (Beer Sheva, IL) Ranolazine improves coronary flow reserve in patients with angina but no obstructive coronary artery disease. – E. Tagliamonte, T. Cirillo, U. Marinelli, C. Astarita, R. Citro, G. Riccio, C. Romano, S. Baldi (Nocera Inferiore, Sorrento and Salerno, IT) P4248 P4249 P4250 P4251 P4252 251 TUESDAY, 28 AUGUST 2012 – MORNING POSTERS Dipyridamole coronary flow reserve stratifies prognosis in patients without left anterior descending disease following an acute coronary syndrome. – G. Carlomagno, L. Ascione, P. Caso, R. Iengo, C. Sordelli, M. Cavallaro, A. D’Andrea, S. Severino, F. Arenga, R. Calabro (Naples, IT) Incorporation of myocardial contrast echocardiography into a clinical stress echocardiography service is feasible and provides additional diagnostic information. – B.N. Shah, N.S. Chahal, S. Bhattacharyya, R.S. Khattar, W. Li, I. Roussin, R. Senior (London, GB) Left ventricular torsion at rest, peak and post-exercise echocardiography. – M. Lopez-Perez, J. Peteiro, A. Lopez-Sainz, A. Bouzas-Mosquera, G. Barge-Caballero, A. Castro-Beiras (A Coruña, ES) Estimation of infarct size using transthoracic measurement of coronary flow reserve in infarct related and reference coronary artery. – V. Giga, M. Dobric, M. Tesic, D. Sobic-Saranovic, B. Beleslin, A. Djordjevic-Dikic, J. Stepanovic, I. Nedeljkovic, M.C. Ostojic, P.M. Seferovic (Belgrade, RS) Prediction of left ventricular function recovery with the use of 2D speckle tracking echocardiography in patients 12 months after acute ST-elevation myocardial infarction. – E. Szymczyk, P. Lipiec, B. Michalski, K. Szymczyk, L. Stefanczyk, B. Wozniakowski, A. Rotkiewicz, J.D. Kasprzak (Lodz, PL) The additive diagnostic role of coronary flow reserve determined by transthoracic doppler echocardiography in assessment of real significance of stenosis on right coronary artery. – Z. Mladenovic, A. Djordjevic Dikic, D. Tavciovski, A. Angelkov Ristic, Z. Jovic, P. Djuric (Belgrade, RS) P4253 P4254 P4255 P4256 P4257 P4258 CARDIOMYOPATHIES: PROGNOSIS QRS fragmentation in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy and complete right bundle branch block. – S. Peters (Gronau, DE) The impact of sleep apnea on the occurrence of heart failure in the patients with hypertrophyic cardiomyopathy. – Y. Ajiro, K. Iwade, R. Tomita, N. Otsuki, H. Hattori, I. Ishida, H. Arashi, Y. Uchida, Y. Kobayashi, N. Tanaka (Yokohama, JP) Predictors of survival in patients with restrictive cardiomyopathy. – J.Y. Jang, D.-H. Kang, B.J. Sun, M.S. Kim, D.H. Kim, J.M. Song, J.-H. Zo, K.-J. Choi, J.-K. Song, J.-J. Kim (Seoul, KR) Characterization of predictors of in-hospital cardiac complications of takotsubo cardiomyopathy: multi-center registry from Tokyo CCU network. – T. Murakami, T. Yoshikawa, Y. Maekawa, T. Ueda, T. Isogai, Y. Konishi, K. Sakata, K. Nagao, T. Yamamoto, M. Takayama (Tokyo, JP) Prognostic role of clinical presentation in patients with hypertrophic cardiomyopathy. A single center experience. – G. Finocchiaro, M. Merlo, B. Pinamonti, G. Barbati, A. Cocciolo, G. Sinagra (Trieste, IT) Left ventricular reverse remodeling in idiopathic dilated cardiomyopathy: a subgroup analysis of the population enrolled at the Florence referral center for cardiomyopathies. – A. Fornaro, G. Castelli, M. Ciaccheri, I. Olivotto, C. Pigozzi, B. Tomberli, G.F. Gensini (Florence, IT) Influence of triggering events on the clinical course of tako-tsubo cardiomyopathy. – B. Schneider, A. Athanasiadis, W. Pistner, J. Schwab, U. Gottwald, W. Toepel, T. Mueller-Honold, R. Schoeller, C. Wegner, U. Sechtem (Lübeck, Stuttgart, Aschaffenburg, Nuremberg, Celle, Idar-Oberstein, Augsburg and Berlin, DE; Vienna, AT) Impact of serum cardiac troponin T and I on cardiac molecular changes and dysfunction in patients with hypertrophic cardiomyopathy. – A. Hirashiki, R. Okamoto, T. Okumura, S. Shimazu, T. Yamada, Y. Bando, X.W. Cheng, T. Kondo, T. Murohara (Nagoya, JP) Assessing prognosis in idiopathic dilated cardiomyopathy: the experience of the Florence referral center for cardiomyopathies. – G. Castelli, A. Fornaro, M. Ciaccheri, I. Olivotto, C. Pigozzi, B. Tomberli, G.F. Gensini (Florence, IT) Fragmented QRS complexes on 12-lead ECG predict myocardial fibrosis in hypertrophic cardiomyopathy. – N. Sheikh, M. Papadakis, R. Bastiaenen, L. Millar, N. Emmanuel, S. Ghani, A. Zaidi, S. Gati, E. Behr, S. Sharma (London, GB) Tissue Doppler imaging and prognosis in asymptomatic or mildly symptomatic patients with hypertrophic cardiomyopathy. – H. Kitaoka, T. Kubo, K. Hayashi, Y. Baba, N. Yamasaki, Y. Matsumura, T. Furuno, Y. Doi (Kochi, JP) Importance of hypertrophy pattern in sudden death risk stratification among patients suffering from hypertrophic cardiomyopathy. – E. Pagourelias, G.K. Efthimiadis, D.G. Parcharidou, T.D. Gossios, H. Karvounis, I.H. Styliadis (Thessaloniki, GR) Prognostic role of a high-sensitivity cardiac troponin T marker in patients with dilated cardiomyopathy. – Y. Baba, T. Kubo, S. Yamanaka, Y. Nakashima, Y. Ochi, N. Yamasaki, Y. Matsumura, T. Furuno, H. Kitaoka, Y. Doi (Kochi, JP) Number of morphological kinds of ventricular premature beats with fragmented QRS waves on 12-lead holter ECG predicted left ventricular fibrosis and fatty change on CT in hypertrophic cardiomyopathy. – K. Ozawa, N. Funabashi, H. Takaoka, A. Kataoka, M. Uehara, Y. Kobayashi (Chiba, JP) 252 P4259 P4260 P4261 P4262 P4263 P4264 P4265 P4266 P4267 P4268 P4269 P4270 P4271 P4272 TUESDAY, 28 AUGUST 2012 – MORNING POSTERS Impact of regional left ventricular function on diagnosis, staging and prognosis in patients with cardiac amyloidosis. – D. Liu, K. Hu, M. Niemann, S. Herrmann, M. Cikes, S. Stoerk, S. Knop, G. Ertl, B. Bijnens, F. Weidemann (Wurzburg, DE; Zagreb, HR; Barcelona, ES) Severe myocardial fibrosis detected by cardiac MRI in patients with hypertrophic cardiomyopathy is associated with high risk for future arrhythmic events. – M. Schwarz, R. Lehmann, I. Ilic, E.M. Prinz, T. Bitter, J. Vogt, D. Horstkotte, L. Faber, C. Prinz (Bad Oeynhausen, DE; Belgrade, RS) Are different ballooning patterns in stress-induced (Takotsubo) cardiomyopathy associated with different clinical backgrounds and outomes? – J. Nishida, K. Tsuchihashi, H. Kouzu, A. Muranaka, N. Kokubu, N. Fujii, S. Yuda, M. Hase, A. Hashimoto, T. Miura (Sapporo, JP) Prognostic value of the admission ECG for predicting complications in patients with tako-tsubo cardiomyopathy. – B. Schneider, U. Desch, J. Stein (Lübeck, DE) P4273 P4274 P4275 P4276 CARDIOMYOPATHIES: TREATMENT Long-term follow-up of 99 patients after transcoronary ablation of septal hypertrophy (TASH) for HOCM: No evidence for the induction of an arrhythmogenic substrate. – T. Lawrenz, M. Schloesser, S. Gottschalk, C. Leuner, H. Kuhn, C. Stellbrink (Witten-Herdecke and Bielefeld, DE) Identification of patients with idiopathic dilated cardiomyopathy and SCD-HeFT inclusion criteria who could be considered for early ICD implantation. – M. Zecchin, A. Pivetta, M. Merlo, C. Lutman, A. Di Lenarda, D. Gregori, G. Barbati, L. Vitali Serdoz, A. Buiatti, G. Sinagra (Trieste and Padua, IT) Surgical correction of HOCM in patients with severe hypertrophy and septal myocardial fibrosis. – K.V. Borisov (Moscow, RU) Long-term recovery of atrioventricular conduction after percutaneous transluminal septal myocardial ablation in patients with hypertrophic obstructive cardiomyopathy. – A. Axelsson, K. Weibring, O. Havndrup, H. Kelbak, E. Jorgensen, S. Helqvist, L. Kober, H. Bundgaard, M.K. Jensen (Copenhagen and Roskilde, DK) Long-term outcomes after heart transplantation for Emery-Dreifuss muscular dystrophy. – J.M. Kracht, A.J. Gay, C. Nafeh-Bizet, M. Redonnet, F. Bouchart, P.Y. Litzler, F. Doguet, A. Tabley, F. Anselme, J.P. Bessou (Rouen, FR) P4277 P4278 P4279 P4280 P4281 CARDIOMYOPATHIES: IMAGING P4282 P4283 P4284 P4285 P4286 TUESDAY – MORNING Distinguishing 320-slice CT-detected focal fibrotic lesions and non-fibrotic lesions in hypertrophic cardiomyopathy by assessment of regional-myocardial-strain using two-dimensional Speckle-Tracking. – A. Kataoka, N. Funabashi, S. Horie, M. Takahashi, K. Ozawa, M. Uehara, H. Takaoka, Y. Kobayashi (Chiba, JP) Hidden right ventricular dysfunction in asymptomatic first-degree relatives of arrhythmogenic right ventricular cardiomyopathy assessed by speckle tracking, compared with strain Doppler. – R. Ancona, S. Comenale Pinto, P. Caso, O. Rapisarda, C. Cavallaro, F. Vecchione, A. D’Onofrio, M. Cavallaro, R. Calabro’ (Naples, IT) Cardiac sarcoidosis has characteristic distribution of late gadolinium enhancement in magnetic resonance imaging in comparison with idiopathic dilated cardiomyopathy. – M. Sano, H. Satoh, K. Shiraki, M. Saotome, T. Urushida, H. Katoh, H. Hayashi (Hamamatsu, JP) Traditional and innovative echocardiographic parameters for the analysis of right ventricular performance in comparison to cardiac magnetic resonance. – M. Cameli, M. Focardi, S.F. Carbone, A. Massoni, R. De Vito, M. Lisi, F.M. Righini, P.C. Ballo, M. Galderisi, S. Mondillo (Siena, Florence and Naples, IT) Speckle tracking and 3D echocardiography in arrhythmogenic right ventricular cardiomyopathy allows to assess new findings about ventricular and atrial function. – R. Ancona, S. Comenale Pinto, P. Caso, C. Cavallaro, F. Vecchione, A. D’Onofrio, O. Rapisarda, M. Cavallaro, R. Calabro’ (Naples, IT) Myocardial fibrosis in apical hypertrophic cardyomiopathy: a study by MRI. – G. Todiere, G.D. Aquaro, P. Piaggi, F. Formisano, A. Barison, P.G. Masci, L. Bacigalupo, E. Strata, A. Pingitore, M. Lombardi (Pisa, Genoa and Florence, IT) Diabetes mellitus and cardiac complications in thalassemia major patients. – A. Pepe, A. Meloni, G. Rossi, V. Caruso, L. Cuccia, A. Spasiano, E. Chiodi, V. Positano, M. Lombardi, M.R. Gamberini (Pisa, Catania, Palermo, Naples and Ferrara, IT) Left ventricular hypertrabeculation in individuals with sickle cell anaemia: physiology or pathology? – S. Gati, N. Von Niekerk, M. Reed, A. Cox, A. Zaidi, S. Ghani, M. Papadakis, M. Ahmed, T. Yeghen, S. Sharma (London, GB) T1 mapping in differentiation of diffuse myocardial disease in hypertrophic and dilative cardiomyopathy. – V. Puntmann, A. Pastor, Z. Chen, T. Voigt, R. Razavi, T. Schaeffter, E. Nagel (London, GB) P4287 P4288 P4289 P4290 CARDIOMYOPATHIES: PATHOPHYSIOLOGY Effect of physical exercise on cardiac remodeling and oxidative stress in diabetic rats. – C. Gimenes, R. Gimenes, C.M. Rosa, G.N. Guirado, M.D.M. Cezar, D.H.S. Campos, A.A.H. Fernandes, A.H.R. Takamoto, M.P. Okoshi, K. Okoshi (Botucatu, BR) P4291 253 TUESDAY, 28 AUGUST 2012 – MORNING POSTERS Dual assessment of coronary flow reserve in non obstructive hypertrophic cardiomyopathy: patophysiological characteristics. – M. Tesic, A. Djordjevic-Dikic, D. Trifunovic, O. Petrovic, I. Nedeljkovic, M. Petrovic, V. Giga, G. Stankovic, B. Beleslin, B. Vujisic-Tesic (Belgrade, RS) Cyclophilin A expression in endomyocardial biopsies predicts clinical outcome of patients with congestive heart failure. – C.S. Zuern, K.A.L. Mueller, P. Seizer, K. Klingel, R. Kandolf, A. Bauer, M. Gawaz, A.E. May (Tübingen, DE) Impaired copper homeostasis in patients with hypertrophic cardiomyopathy. – R. Potluri, N. Roberts, C. Miller, N. Brooks, S. Ray, G. Cooper, M. Schmitt (Manchester and Liverpool, GB) Tyrosyl-tRNA synthetase: peculiarities of myocardial expression and autoimmune reactions at dilated cardiomyopathy. – D.V. Riabenko, I.U.I.U. Kondratiuk, V.I. Bobyk, L.L. Sidorik, A.I. Kornelyuk (Kyiv, UA) Cardiotoxic anticancer agents induce an increase in myocardial weight: a pathophysiologic study of altered cardiac mechanics. – M. Arao, M. Sekine, K. Setsuta, K. Mizuno (Tokyo, JP) P4292 P4293 P4294 P4295 P4296 CARDIOMYOPATHIES: DIAGNOSIS A French registry of takotsubo syndrome in non-academic hospitals (OFSETT). – L. Belle, J.J. Dujardin, M. Hanssen, S. Cattan, F. Albert, J.L. Georges, X. Marcaggi, D. Logeart, J.F. Aupetit, G. Mulak (Annecy, Douai, Haguenau, Montfermeil, Chartres, Versailles, Vichy, Paris and Lyon, FR) Syncope in hypertrophic cardiomyopathy: the diagnostic role of flow mediated dilalation. – R. Morgagni, A. Capria, S. Verbena, M. Macrini, L. Zerillo, I. Cazzoli, F. Romeo (Rome, IT) The extent and consequences of diagnostic uncertainty in individuals assessed for arrhythmogenic right ventricular cardiomyopathy. – D. Lee, P. Brennan, S. Lord (Newcastle-upon-Tyne, GB) In dilated cardiomyopathy the stimulating potential of anti-beta1-receptor autoantibodies is positively correlated with the depression of left ventricular function. – A. Schlipp, V. Boivin, J. Ullrich, M. Bauer, D. Leyh, N. Deubner, M.J. Lohse, G. Ertl, R. Jahns (Wurzburg, DE) Performance of task force diagnostic criteria for identification of symptomatic patients in the nordic arrhythmogenic right ventricular cardiomyopathy registry. – P.G. Platonov, A.G. Holst, K. Haugaa, T. Edvardsen, T. Gillijam, C. Lundin, O. Eschen, J. Hansen, H. Bundgaard, J.H. Svendsen (Lund and Gothenburg, SE; Copenhagen and Aalborg, DK; Oslo, NO) The impact of dynamic intraventricular obstruction on left ventricular mechanics in hypertrophic cardiomyopathy. – M. Rosca, B.A. Popescu, M. Gurzun, A. Calin, C.C. Beladan, R. Enache, I.M. Coman, C. Ginghina (Bucharest, RO) Cardiomyopathy in mitral valve prolapse. – E. Malev, E. Zemtsovsky, L. Vasina, A. Pshepiy, A. Korshunova (St. Petersburg, RU) Prevalence of psychiatric disorders in Tako-Tsubo cardiomyopathy. – D. Doyen, S. Moschietto, P. Moceri, F. Bernasconi, T. Tibi, P. Cerboni, E. Ferrari (Nice, Antibes and Cannes, FR) Left ventricular non compaction: prevalence in various types of congenital heart disease. – B.E. Staehli, C. Gebhard, P. Biaggi, S. Klaassen, E. Buechel Valsangiacomo, C.H. Attenhofer Jost, R. Jenni, F.C. Tanner, M. Greutmann (Zurich, CH; Berlin, DE) Clinical characteristics and short-term outcome of patients with Tako-tsubo syndrome and critical coronary stenosis: comparison with patients with Tako-tsubo with normal coronary arteries. – M. Previtali, G. Crimi, A. Valbusa, A. Bartolini, A. Repetto, M. Rossi, P. Rubartelli, F. Chiarella, L. Oltrona Visconti (Pavia and Genoa, IT) P4297 P4298 P4299 P4300 P4301 P4302 P4303 P4304 P4305 (W) P4306 VASCULAR BIOLOGY I Completely autologous biotube vascular grafts: eosin Y significantly promoted in vivo formation of functional biotubes in a short term. – Y. Nakayama, T. Tujinaka, T. Watanabe, M. Yamanami, K. Kanda, H. Yaku (Osaka and Kyoto, JP) Angiotensin II inhibits ecSOD and ATP7A and upregulates oxidative stress via toll-like receptor 4. – T. Nakashima, S. Umemoto, T. Okamoto, S. Matsuda, T. Murata, K. Yoshimura, T. Fukai, M. Matsuzaki (Ube and Yamaguchi, JP; Chicago, US) The temporal and spatial distribution of macrophage subpopulations during arteriogenesis. – C. Troidl, G. Jung, K. Troidl, J. Hoffmann, S. Voss, H. Nef, W. Schaper, C.W. Hamm, T. Schmitz-Rixen, H. Moellmann (Bad Nauheim, Giessen and Frankfurt am Main, DE) Insulin induced vasoreactivity is impaired after short-term high fat feeding and is dependent on perivascular adipose tissue as well as resistance artery properties. – R.I. Meijer, E.C. Serne, J.S. Yudkin, C.A.F. Alta, E.J. Barrett, V.W. Van Hinsbergh, Y.M. Smulders, E.C. Eringa (Amsterdam, NL; London, GB; Charlottesville, US) Saphenous vein aorto-coronary bypass graft atherosclerosis in patients with chronic kidney disease: more clacification, but less vasoconstrictor potential. – T. Baars, P. Kleinbongard, T. Konorza, S. Moehlenkamp, D. Boese, H. Degen, J. Hippler, M. Haude, R. Erbel, G. Heusch (Essen, Moers and Neuss, DE) Comparison of circulating microparticles counts in patients with acute coronary syndrome with two methodologies. – S. Montoro-Garcia, A. Lopez-Cuenca, A.I. Romero, F. Marin, M. Valdes, E. Shantsila, S. Manzano-Fernandez, D. Hernandez-Romero, E. Orenes-Pinero, G.Y.H. Lip (Birmingham, GB; Murcia, ES) 254 P4307 P4308 P4309 P4310 P4311 P4312 TUESDAY, 28 AUGUST 2012 – MORNING POSTERS The effect of treatment with drospirenone/ethinyl estradiol alone or in combination with metformin on elastic properties of aorta in women with polycystic ovary syndrome. – M.G. Kaya, B. Calapkorur, A. Celik, M. Akpek, Z. Karaca, S. Yildirim, K. Unluhizarci, F. Kelestimur (Kayseri, TR) Fibrin-related thrombosis risk in type 2 diabetes: relationship with vascular pathology and drug therapy. – K.A. Hess, S.H. Alzahrani, J.F. Price, M. Strachan, P.D. Baxter, R. Cubbon, F. Phoenix, N. Marx, P.J. Grant, R.A. Ajjan (Aachen, DE; Leeds and Edinburgh, GB) Molecular mechanism of tissue factor regulation through RAGE-MT1-MMP axis in HMGB-1 stimulated-endothelial cells. – K. Sugimoto, T. Ishibashi, Y. Takuwa, Y. Takeishi (Fukushima and Kanazawa, JP) Pharmacokinetic interactions between clopidogrel and rosuvastatin: effects on vascular protection in subjects with coronary heart disease. – L.F.M. Pinheiro, M.C. Izar, C.N. Franca, S.P. Barbosa, H.T. Bianco, S.M. Kasmas, R.M.S. Povoa, F.A.H. Fonseca (São Paulo, BR) Endothelial progenitor cells in relation to endothelin-1 and endothelin receptor blockade: a randomized controlled trial. – C. Jung, A. Rafnsson, J. Pernow (Stockholm, SE) Soluble adenylyl cyclase controls oxidative stress-induced apoptosis of smooth muscle cells. – S. Kumar, A. Appukuttan, H.P. Reusch, Y. Ladilov (Bochum, DE) The p110alpha subunit of PI 3-kinase is crucially involved in neointima formation by mediating smooth muscle cell proliferation, migration and survival. – J. Jesus, M. Vantler, E. Berghausen, E. Caglayan, H. Ten Freyhaus, O. Leppaenen, J. Zhao, S. Rosenkranz (Cologne, DE; Uppsala, SE; Boston, US) Chronic signaling of the survival factor PDGF leads to smooth muscle cell death in atherosclerotic plaques. – M. Vantler, L. Zhou, M. Schwab, M. Zierden, W.H. Zimmermann, J. Herz, S. Rosenkranz (Cologne and Göttingen, DE; New York and Dallas, US) P4313 P4314 P4315 P4316 P4317 P4318 P4319 P4320 VASCULAR BIOLOGY II P4321 P4322 P4323 P4324 P4325 P4326 P4327 TUESDAY – MORNING Neutrophils contribute to DVT formation by forming procoagulant and prothrombotic neutrophil extracellular traps. – K. Stark, M.L. Von Bruehl, A. Steinhart, S. Chandraratne, M. Lorenz, R. Coletti, S. Pfeiler, D. Manukyan, B. Engelmann, S. Massberg (Munich, DE) Small-size circulating microparticles in post myocardial infarction patients: changes over 30 days and relationship to the fibrinolytic status. – S. Montoro-Garcia, E. Shantsila, L. Tapp, B.J. Wrigley, F. Marin, G.Y.H. Lip (Birmingham, GB; Murcia, ES) Leptin is expressed in human carotid atherosclerotic plaques and plays an active role in plaque stability via its effects on human vascular smooth muscle cells phenotype. – A. Dupont, A. Elkalioubie, C. Zawadzki, M. Tagzirt, C. Lavisse, B. Staels, S. Haulon, B. Jude, S. Susen, E. Van Belle (Lille, FR) Endothelial Microparticles (EMP) are taken up in an Annexin I/PSR dependent pathway by target cells and promote endothelial regeneration. – F. Jansen, X. Yang, F.F. Hoyer, K. Paul, U.M. Becher, M. Kebschull, J. Bedorf, G. Nickenig, N. Werner (Bonn, DE) Lack of junD promotes oxidative stress-induced vascular aging. – E. Osto, F. Paneni, B. Mateescu, P. Mocharla, S. Briand, E. Perna, A. Akhmedov, C. Matter, T. Luscher, F. Cosentino (Zurich, CH; Paris, FR) Impaired periaortic adipocyte differentiation in angiotensin AT1 receptor deficient mice: Possible role in pro-inflammatory phenotypic modulation of perivascular adipose tissue. – H. Yamada, D. Irie, T. Kato, H. Kawahito, S. Kishida, K. Ikeda, M. Okigaki, H. Matsubara (Kyoto, JP) Krueppel-like factor 4 is downregulated in circulating monocyte subsets of patients with Coronary Artery Disease. – F.S. Czepluch, H. Kuschicke, M. Schlegel, M. Mueller, M. Bernhardt, F. Bremmer, J. Riggert, G. Hasenfuss, K. Schaefer (Göttingen, DE) Is NGAL assessment in patients referred to renal artery stenting for atherosclerotic renal artery occlusive disease of clinical value? – D. Rzeznik, T. Przewlocki, A. Kablak-Ziembicka, A. Roslawiecka, A. Kozanecki, M. Kostkiewicz, K. Zmudka, P. Podolec (Krakow, PL) Decrease in circulating myeloid and plasmacytoid Dendritic Cell Precursors (dcps) in patients with Chronic Kidney Disease stage 3. – D. Kretzschmar, K.P. Paul, H.R.F. Figulla, G.W. Wolf, M.B. Busch, A.Y. Yilmaz (Jena, DE) Quantification of new structural features of coronary plaque components by post-hoc computational analysis of Virtual-Histology IVUS images. – T. Papaioannou, D. Schizas, M. Vavuranakis, O. Katsarou, D. Soulis, C. Stefanadis (Athens, GR) Hypoxia reoxygenation-induced endothelial barrier failure: Role of RhoA, Rac1, and MLCK. – M. Aslam, S. Rohrbach, K.-D. Schluter, D. Sedding, C. Hamm, T. Noll, D. Guenduez (Giessen and Dresden, DE) Uric acid levels are associated with asymmetric dimethylarginine, L-arginine and arterial stiffness in essential hypertensive patients. – K. Dimitriadis, C. Tsioufis, A. Kasiakogias, M. Giakoumis, I. Bafakis, K. Kintis, I. Andirikou, D. Tousoulis, C. Stefanadis (Athens, GR) P4328 P4329 P4330 P4331 P4332 255 TUESDAY, 28 AUGUST 2012 – MORNING POSTERS The paraoxonase 55 L/M polymorphism influences the onset of acute coronary syndrome but not stable angina. – S. Gomes, A. Pereira, A.C. Sousa, B. Silva, S. Freitas, G. Guerra, A. Brehm, J.J. Araujo, M. Mendonca, R. Palma Dos Reis (Funchal and Lisbon, PT) Angiotensin II induces early mechanical heterogeneity along the abdominal aorta, preceding murine aneurysm formation. – U. Raaz, L. Maegdefessel, R. Toh, A. Deng, J.M. Spin, P.S. Tsao (Stanford, US) Phenotypic characterization of leukocytes at the culprit lesion site in acute coronary syndrome patients. – A. Mangold, S. Puthenkalam, K. Distelmaier, C. Adlbrecht, K.T. Preissner, I.M. Lang (Vienna, AT; Giessen, DE) Circulating apoptotic endothelial cells and apoptotic endothelial microparticles independently predict the presence of cardiac allograft vasculopathy. – N. Singh, E. Van Craeyveld, M. Tjwa, A. Ciarka, W. Droogne, S. Gordts, F. Jacobs, J. Vanhaecke, J. Van Cleemput, B. De Geest (Leuven, BE) The experimental study of a new kind absorbable magnesium alloy stent. – Y. Shuixiang, L.L. Wang, Y.X. Cui, E.D. Wang, J.P. Yang, J.W. Zhu, P. Wang, L.C. Lei (Beijing, CN) Angiotensin-(1-7) suppresses the number and function of the circulating fibrocytes by upregulating endothelial nitric oxide synthase expression. – K. Wang, X.S. Hu, C.Q. Du, S.K. Tu, F.R. Zhang, X.D. Xie (Hangzhou, CN) P4333 P4334 P4335 P4336 P4337 P4338 VASCULAR REMODELLING Wnt4 contributes to intimal thickening by promoting VSMC proliferation via up-regulation of RCAN1. – A. Tsaousi, H. Williams, G.M. Connolly, S.J. George (Bristol, GB) A non-polymeric ciglitazone-eluting stent inhibits neointimal proliferation stronger than sirolimus-eluting stents: an experimental study using optical coherence tomography in rabbit iliacal arteries. – T.C. Poerner, S. Otto, H. Schubert, B. Romeike, D. Haase, H.R. Figulla (Jena, DE) Functional inhibition of microRNA-92a increases endothelial regeneration and reduce neointimal formation after vascular injury by targeting kruppel-like factor-4. – C. Iaconetti, A. Polimeni, S. Sorrentino, J. Sabatino, G. Pironti, G. Esposito, A. Curcio, C. Indolfi (Catanzaro and Naples, IT) The PI 3-kinase isoform p110alpha promotes vascular remodelling in pulmonary arterial hypertension. – E.M. Berghausen, M. Vantler, W. Janssen, H. Ten Freyhaus, J.J. Zhao, R.T. Schermuly, S. Rosenkranz (Cologne, Bad Nauheim and Giessen, DE; Boston, US) Two-chain High Molecular Weight Kininogen (HKa) inhibits neointimal lesion formation by preventing leukocyte recruitment. – J.-M. Daniel, F. Reich, J. Dutzmann, K.T. Preissner, C.W. Hamm, D.G. Sedding (Giessen, DE) Hyaluronic acid metabolism is increased in human abdominal aortic aneurysm. – T. Miyoshi, T. Yonezawa, M. Doi, A. Aoki, K. Nakamura, S. Hirohata, S. Kusachi, Y. Ninomiya, K. Kusano, H. Ito (Okayama and Takamatsu, JP) Valsartan inhibits aortic remodeling by blocking transforming growth factor-beta 1-Smads pathway in diabetic rats. – H. Sun, Y. Zhao, W. Zhang, M. Zhong, G. Su (Jinan, CN) A novel adipocytokine, CTRP9 attenuates vascular smooth muscle cell proliferation and neointimal formation after vascular injury. – Y. Uemura, R. Shibata, K. Ohashi, T. Enomoto, T. Kambara, T. Murohara, N. Ouchi (Nagoya, JP) Furin-dependent maturation of proNGF induces migration of vascular smooth muscle cells by TrkA-mediated recruitment of paxillin to focal adhesion sites. – D. Urban, J. Lorenz, H. Meyborg, S. Gosh, J. Kaufmann, K. Kappert, E. Fleck, P. Stawowy (Berlin, DE) MicroRNA-146a and its role in endothelial cells during vascular remodeling processes. – R. Widmer-Teske, W. Bielenberg, J.-M. Daniel, H. Nef, C. Troidl, S. Achenbach, C. Hamm, D. Sedding (Giessen, DE) MicroRNA-146a and its role in vascular smooth muscle cells during vascular remodeling processes. – D. Sedding, W. Bielenberg, J.-M. Daniel, H. Nef, C. Troidl, S. Achenbach, C. Hamm, R. Widmer-Teske (Giessen, DE) Ablation of PDGF receptor signaling reduces neointima formation after balloon angioplasty and does not affect the proliferation and migration of endothelial cells. – T. Kramer, M. Vantler, E. Caglayan, M. Scherner, O. Leppaenen, S. Rosenkranz (Cologne, DE; Uppsala, SE) Changes of elastic properties of large arteries in systemic sclerosis are related to endothelial activation and matrix tissue remodelling. – K. Irzyk, M. Ciurzynski, P. Bienias, Z. Rymarczyk, M. Kostrubiec, Z. Bartoszewicz, U. Demkow, A. Szewczyk, M. Siwicka, P. Pruszczyk (Warsaw, PL) Border zone coronary collateral network detected with an imaging cryomicrotome in the infarcted human heart. – P.H.M. Van Den Wijngaard, P. Van Horssen, A.C. Van Der Wal, M.G.J.T.B. Van Lier, M. Brandt, J.A.E. Spaan, M. Siebes (Amsterdam, NL) Angiotensin II (AngII)-induced arterial remodeling is associated with upregulation of miR-21 and downregulation of miR-29b. – U. Raaz, L. Maegdefessel, R. Toh, A. Deng, J.M. Spin, P.S. Tsao (Stanford, US) Changes of vascular walls in different levels of arterial system in patients with stable coronary artery disease and type 2 diabetes mellitus. – A.A. Shchendrygina, Y.N. Belenkov, E.V. Privalova, Y.A. Danilogorskaya, E.A. Zheleznykh (Moscow, RU) 256 P4339 P4340 P4341 P4342 P4343 P4344 P4345 P4346 P4347 P4348 P4349 P4350 P4351 P4352 P4353 P4354 TUESDAY, 28 AUGUST 2012 – MORNING POSTERS ASSESSMENT & INTERVENTION TO IMPROVE P4355 P4356 P4357 P4358 (W) P4359 P4360 P4361 P4362 P4363 P4364 P4365 P4366 P4367 P4368 P4369 P4370 P4371 TUESDAY – MORNING Relationship between red cell distribution width (RDW) and clinical outcomes in non-ST elevation myocardial infarction and unstable angina pectoris: 3-years follow-up. – M. Gul, H. Uyarel, M. Ergelen, D. Karacimen, M. Ugur, M. Bozbey, A. Turer, E. Ayhan, O. Akgul, N. Uslu (Istanbul and Balikesir, TR) Echocardiographic epicardial fat thickness is associated with arterial stiffness. – B.J. Kim, B.S. Kim, J.H. Kang (Seoul, KR) Plasma BNP versus cardiac risk scores for risk stratification after major orthopedic surgery. – S. Katsanos, N. Kafkas, D. Leong, A. Mavrogenis, C. Varounis, D. Babalis, J. Parissis, M. Anastasiou-Nana, G. Filippatos (Athens, GR; Leiden, NL) Multiple biomarkers improve the prediction of cardiovascular mortality in patients on chronic hemodialysis. – H. Takahashi, H. Ishii, Y. Kumada, T. Aoyama, D. Kamoi, J. Ishii, T. Murohara, M. Tanaka (Nagoya and Toyoake, JP) Causality of inflammation related to blood leucocyte count for the progression of arterial stiffness and pressure wave reflection. – H. Tomiyama, M. Odaira, M. Yoshida, C. Matsumoto, K. Shiina, A. Yamashina (Tokyo, JP) Prognostic relevance of epicaridal adipose tissue in patients with coronary artery disease assessed by cardiovascular magnetic resonance. – C. Doesch, D. Haghi, T. Suselbeck, R. Lany, S.O. Schoenberg, M. Borggrefe, T. Papavassiliu (Mannheim, DE) Mild/moderate renal dysfunction: its role in the preoperative evaluation. – L.W. Ramos, L. Nicoletti, F. Ignacio, E. Castilho, E. Elly, B. Cristina, M. Wolf, M. Calil, J.C.S. Goes (São Paulo, BR) Systematic review of risk factors for upper gastrointestinal bleeding in patients using low-dose acetylsalicylic acid. – V.E. Valkhoff, E.J. Kuipers, R. Pearce, A. Lanas (Rotterdam, NL; Oxford, GB; Zaragoza, ES) Contrast-induced nephropathy (CIN) after primary percutaneous coronary intervension (PCI); the role of heat shock proteins. – A.K. Jaroszynska, A. Glowniak, A. Wysokinski, A. Jaroszynski (Lublin, PL) Incidence, risk factors, and outcomes of perioperative Acute Kidney Injury in noncardiac and nonvascular surgery. – M. Biteker, A. Dayan, A.I. Tekkesin, M.M. Can, E. Ilhan (Istanbul, Malatya and Van, TR) The radial artery amplification index is an integrator of cardiovascular risk and general atherosclerotic burden. – D. Rosenbaum, F. Rached, E. Bruckert, P. Giral, X. Girerd (Paris, FR) The association between brachial-ankle pulse wave velocity and the extent of coronary artery disease in patients with angina. – I.H. Jung, S.Y. Lee, M.J. Choi, D.S. Lim, S.J. Lee, J.H. Kim, Y.M. Rho, W.H. Shim (Bucheon and Seoul, KR) The existence of non-obstructive plaque in carotid artery predicts cardiovascular death in patients of end-stage renal disease on maintenance hemodialysis. – H.T. Hsin, S.R. Ke, Y.S. Peng (Taipei and New Taipei City, TW) Impact of type 2 diabetes and coronary heart disease on cardiovascular risk in high-risk hypertensive patients: a subanalysis of the CASE-J Ex. – S. Yasuno, K. Ueshima, S. Tanaka, A. Fujimoto, M. Kasahara, Y.M. Nakao, T. Ogihara, T. Saruta, K. Nakao (Kyoto, Osaka and Tokyo, JP) Fasting serum apolipoprotein B-48 levels were correlated with the prevalence of coronary artery disease. – D. Masuda, T. Sugimoto, T. Ohama, M. Nishida, M. Ishigami, T. Kawamoto, A. Matsuyama, N. Sakai, I. Komuro, S. Yamashita (Osaka, Hiroshima and Kobe, JP) Development and psychometric properties of the Heart Failure Knowledge Scale in Japan. – N. Kato, K. Kinugawa, E. Nakayama, T. Tsuji, Y. Kumagai, C. Miura, M. Nagayama, T. Sumiyoshi, H. Tomoike, R. Nagai (Tokyo, JP) Short duration holter monitoring is equally as good as daily monitoring in heart rate and pause assessment. – S. Fall, T. O’Hora, O. Macavaney, V. Maher (Dublin, IE) Diagnostic angiography with 5F catheters supports early ambulation and discharge. – V. Gatt, M. Borg, J. Agius, A. Fenech, R.G. Xuereb, V. Grech (Msida, MT) The evolving role of the angina specialist nurse in a district general hospital in the UK. – J. Caton, C. Dereszkiewicz, N. Naqvi (Wigan, GB) Groin dressing post cardiac catheterization: traditional pressure versus transparent film. – R. Al-Shualah (Jubail, SA) PCI in very elderly patients suffering an ACS. – M. Gusai, P. Merella, G. Peddis, G. Casu (Nuoro, IT) Preoperative statin use and postoperative atrial fibrillation after major noncardiac, nonvascular surgery. – M. Biteker, A. Dayan, M.M. Can, E. Ilhan, A. Tekkesin (Istanbul, Malatya and Van, TR) Carperitide can protect against acute kidney injury in patients with chronic kidney disease undergoing coronary angiography. – T. Senoo, K. Manabe, S. Umemura, M. Motohiro, H. Kamihata, T. Iwasaka (Hirakata, JP) Effects of community-based general practitioners-led care for 12,864 patients with hypertension: study of cardiovascular risk intervention - hypertension (SCRI-HTN) in China. – H.H.X. Wang, J.J. Wang (Shatin, HK; Guangzhou, CN) P4372 P4373 P4374 P4375 P4376 P4377 P4378 257 TUESDAY, 28 AUGUST 2012 – MORNING POSTERS The ability of N-terminal B-type natriuretic peptide and microalbuminuria for identifying high risk patient of cardiovascular disease in a large community cohort. – J.W. Lee, B.S. Yoo, J.H. Lee, Y.J. Youn, M.S. Ahn, S.G. Ahn, J.Y. Kim, S.H. Lee, J. Yoon, K.H. Choe (Wonju, KR) Pravastatin combined with valsartan shows additive beneficial vascular effects in patients with hypercholesterolemia. – K. Koh, H. Choi (Incheon, KR) P4379 (W) P4380 (W) MIND, BODY & BEHAVIOUR: IMPLICATIONS IN CARDIOVASCULAR RISK AND DISEASE Anxiety in patients with chronic heart failure: impact of perception of control and acceptance coping. – C. Nahlen, G. Bjorling, M. Elfstrom, H. Persson, F. Saboonchi (Stockholm and Västerås, SE) Depressed chronic heart failure patients have impaired autonomic function. – S.J. Lonie, A. Stewart, D. Toia, D. Hare (Melbourne, AU) Adherence to beta-blocker therapy in heart failure patients. – H.D. Duengen, D.O. Obradovic, S. Inkrot, E. Tahirovic, N. Opacic, L. Stark, T. Trippel, V. Tscholl, J. Mueller-Nordhorn, N. Rieckmann (Berlin, DE; Krusevac, RS) Illness behaviour and gender in cardio-surgical patients. – M. Ferratini, M. Modica, R. Spezzaferri, P. Castiglioni (Milan, IT) Effects of lifestyle factors, disease history and awareness on health-related quality of life in a Thai population. – P. Vathesatogkit, M. Woodward, M. Kimman, E.S. Tai, W. Aekplakorn, B. Hengprasith, H.L. Wee, P. Sritara (Sydney, AU; Singapore, SG; Bangkok and Nonthaburi, TH) The sicker refuse getting healthier: cardiac rehabilitation acceptance paradox. – M. Krawczyk, M. Dominiak, M. Kurpesa, T. Rechcinski, J.D. Kasprzak (Lodz, PL) Dementia as an independent predictor of mortality for one year after hospital discharging of elderly subjects with cardiovascular diseases. – L.N. Matos, A. Frisoli Jr, E.R. Alves, L.F. Guimaraes, A.R. Diniz, E.T. Pinto, A. Greco, I. Helber, A.C. Carvalho (São Paulo, BR) The difference of QOL between older and younger patients with atrial fibrillation in Japan. – Y. Tanimoto, S. Kohsaka, I. Ueda, T. Kimura, N. Nishiyama, K. Fukumoto, Y. Aizawa, K. Tanimoto, S. Takatsuki, K. Fukuda (Tokyo, JP) Anxiety, obesity and cortisol levels in patients with acute coronary syndrome. – A.L. Arrebola Moreno, R. Marfil-Alvarez, R. Garcia-Retamero, V. Alcalde, F. Ruiz-Cabello, R. Melgares, A. Catena, J.A. Ramirez-Hernandez (Granada, ES) Clinical correlations of cognitive impairment in chronic heart failure. – M. Nikolaou, J. Parissis, T. Katsoulas, M. Thodi, I. Behlivanoglou, G. Zisis, V. Gaitani, E. Rentoukas, G. Filippatos, M. Anastasiou Nana (Athens, GR) Symptom profile of hypertensive primary care patients with undiagnosed obstructive sleep apnea - a structural equation model analysis. – A. Brostrom, O. Sunnergren, P. Johansson, E. Svensson, M. Ulander, P. Nilsen, E. Svanborg (Linköping and Jönköping, SE) Differences in cardiovascular signs and risk factors among hypertensive middle aged men and women with high vs. low risk on the Berlin sleep apnea questionnaire. – A. Brostrom, P. Johansson, B. Riegel, P. Nilsen, B. Fridlund, E. Svanborg (Linköping and Jönköping, SE; Philadelphia, US) Is increased high-sensitive troponin T associated with severity of sleep apnoea syndrome? – N. Troester, M. Palfner, M. Dominco, A. Avian, H. Olschewski (Graz, AT) Nutritional assessment in a Universitary Department of Cardiology. – A.I. Romero, C. Fernandez-Redondo, M. Quintana-Giner, S. Manzano-Fernandez, M.R. Gracia-Rodenas, E. Jover, D. Hernandez-Romero, E. Orenes-Pinero, M. Valdes, F. Marin (Murcia, ES) Frequency of returning to work after ST segment elevation myocardial infarction. – E. Trzos, B.-U. Uznanska-Loch, R.-B. Bugielska, T.-R. Rechcinski, J.-K. Kasprzak, U.C.-G. Cieslik-Guerra, Z.B. Bednarkiewicz, M. K.-P. Krzeminska-Pakula, M.K. Kurpesa (Lodz, PL) Adherence to the Mediterranean diet reduces the likelihood of acute coronary syndromes, even among people with high anxiety rates: a case-control study. – C.M. Kastorini, H.J. Milionis, E. Georgousopoulou, M. Symeopoulou, S. Bitsi, A. Vemmou, V. Nikolaou, K.N. Vemmos, J.A. Goudevenos, D.B. Panagiotakos (Ioannina and Athens, GR) Evaluation of cardiovascular disease patients and healthy subjects as regards risk factors’ knowledge and beliefs. – C.M. Kastorini, H.J. Milionis, E. Bika, E. Ntziou, M.S. Kostapanos, E. Georgousopoulou, V. Nikolaou, K.N. Vemmos, J.A. Goudevenos, D.B. Panagiotakos (Ioannina and Athens, GR) Hip fracture and risk of acute myocardial infarction: a nationwide study. – C.H. Chiang, H.B. Leu, Z.Y. Chen (Taipei, TW) Secular trends in women with acute coronary syndrome (ACS) referred to coronary artery angiography: a 15-year observation of the University Hospital Bern. – H. Saner, J. Mollet, S. Cook, S. Windecker, P. Eser, P. Stute, B. Meier (Bern and Fribourg, CH) Physical activity attenuates subclinical atherosclerosis in subjects with chronic spinal cord injury. – W. Nadruz Junior, J.R. Matos-Souza, A.A. Costa E Silva, L.F. Campos, D. Goulart, M. Etchebehere, J.I. Gorla, A. Cliquet Jr (Campinas, BR) Vitamin D deficiency in relation to circulating inflammatory cells and inflammatory markers among apparently healthy individuals. – V. Bountziouka, T. Akalestos, N. Vallianou, A. Evangelopoulos, M. Bonou, P. Avgerinos, E. Vogiatzakis, J. Barbetseas, D.B. Panagiotakos (Athens, GR) 258 P4381 P4382 P4383 P4384 (W) P4385 P4386 P4387 P4388 P4389 P4390 P4391 P4392 P4393 P4394 P4395 P4396 P4397 P4398 P4399 P4400 P4401 TUESDAY, 28 AUGUST 2012 – MORNING POSTERS Genetic predisposition to higher blood pressure increases coronary artery disease risk. – W. Lieb, H. Jansen, C. Loley, M.P. Reilly, R. Mcpherson, I.R. Koenig, J. Erdmann, N.J. Samani, R.S. Vasan, H. Schunkert (Greifswald and Lübeck, DE; Philadelphia and Boston, US; Ottawa, CA; Leicester, GB) Mitochondrial haplogroups H and J: risk and protective factors for ischemic cardiomyopathy. – M. Fernandez-Caggiano, J. Barallobre-Barreiro, I. Rego-Perez, M.G. Crespo-Leiro, Z. Grille, F.J. Blanco, N. Domenech Garcia (Corunna, ES) Prediction of ischemic events based on transcriptomic and genomic profiling in patients undergoing carotid endarterectomy. – J. Persson, L. Folkersen, J. Ekstrand, H.E. Agaradh, G.K. Hansson, A. Gabrielsen, U. Hedin, G. Paulsson-Berne (Stockholm, SE) Genetic variants primarily associated with type 2 diabetes also affect coronary artery disease risk. – H. Jansen, W. Lieb, C. Loley, M.P. Reilly, R. Mcpherson, I.R. Koenig, J. Erdmann, N.J. Samani, R.S. Vasan, H. Schunkert (Lübeck and Greifswald, DE; Philadelphia and Boston, US; Ottawa, CA; Leicester, GB) Impact of arterial stiffness on adverse cardiovascular outcomes and mortality in peritoneal dialysis patients. – M.G. Kaya, M. Sipahioglu, H. Kucuk, A. Unal, F. Oguz, B. Tokgoz, O. Oymak, C. Utas (Kayseri, TR) Cardiovascular disease incidence and compliance on treatment stategy in patients with familial hypercholesterolemia. – V. Metaxa, I. Skoumas, C. Pitsavos, E. Oikonomou, C. Masoura, E. Tsetsekou, C. Stefanadis (Athens, GR) Association of male pattern baldness with angiographic coronary artery disease severity and collateral development. – I. Sari, K. Aykent, V. Davutoglu, M. Yuce, O. Ozer, M. Kaplan, H. Alici, S. Ercan, M. Aksoy (Gaziantep, TR) Risk factors for coronary plaque progression in patients with far east Aasians - A serial volumetric IVUS analysis. – A. Hirohata, K. Yamamoto, E. Hirose, Y. Kobayashi, F. Sano, H. Takafuji, M. Ohara, R. Yoshioka, Y. Iino, T. Ohe (Okayama, JP) Acute coronary syndrome: a serious threat even at age 40. – F. Saraiva, H. Martins, S. Monteiro, F. Goncalves, P. Monteiro, L. Goncalves, L.A. Providencia (Coimbra, PT) P4402 P4403 P4404 P4405 P4406 P4407 P4408 P4409 P4410 RENAL DENERVATION THERAPY IN HYPERTENSION P4411 P4412 P4413 P4414 P4415 P4416 P4417 TUESDAY – MORNING One year pooled outcomes following renal sympathetic denervation in patients with resistant hypertension: From the Symplicity HTN-2 trial. – M. Böhm, M.P. Schlaich, H. Krum, R.E. Schmieder, P. Sobotka, M.D. Esler (Homburg and Erlangen, DE; Melbourne, AU; Mountain View, US) Percutaneous renal sympathetic denervation exerts a chronic effect on renal hemodynamics using a novel catheter for radiofrequency ablation: data from an animal study. – K. Dimitriadis, C. Tsioufis, V. Papademetriou, D. Tsiachris, C. Thomopoulos, A. Kasiakogias, E. Park, C. Hata, C. Stefanadis (Athens, GR; Washington and Irvine, US) Renal sympathetic denervation - inducing an immediate and persisting blood pressure lowering effect. – A. Plehn, S. Dietz, M. Leuthold, T. Schubert, A. Vogt, D. Holzapfel, M. Buerke, S. Markau, M. Girndt, K. Werdan (Halle, DE) Renal denervation for resistant hypertension: real world outcomes. – D.M. Mylotte, M.C. Morice, T. Unterseeh, Y. Louvard, T. Lefevre, P. Garot, H. Benamer (Massy, FR) Renal sympathetic denervation with brachytherapy using beta-radiation catheter. Results from a feasibility and safety preclinical study. – R. Waksman, I. Barbash, R. Chan, R. Torguson, D. Hellinga, R. Baffour, R. Seabron, F. Kelodgie, R. Virmani (Washington and Gaithersburg, US) Effect of renal sympathetic denervation on blood pressure and renal perfusion in a pig model for obstructive sleep apnea. – D. Linz, M. Loehn, F. Mahfoud, C. Ukena, W. Linz, K. Wirth, M. Böhm (Homburg and Frankfurt/Main, DE) Percutaneous renal denervation (PRD) improves central hemodynamics and arterial stiffness - a pilot study. – K.F. Franzen, K. Mortensen, F. Himmel, J. Stritzke, J. Koester, J. Bock, H. Schunkert, J. Weil, M. Reppel (Lübeck, DE) Age-dependent effects of renal denervation therapy on diastolic blood pressure and pulse pressure. – C. Fatum, K. Mortensen, F. Himmel, M. Reppel, C. Gisbertz, F. Bode, H. Schunkert, J. Weil (Lübeck, DE) P4418 RENIN–ANGIOTENSIN–ALDOSTERONE SYSTEM IN HYPERTENSION Pleiotropic role of angiotensin-converting-enzyme inhibitors on bone remodeling biomarkers in hypertensive subjects. – E.L. Stepien, T. Wilkosz, E. Wypasek, M. Tlalka, M. Pasowicz (Krakow, PL) The Effect of sRAGE in inhibiting Angiotensin II-mediated Atherosclerosis in Apolipoprotein E deficient mice. – S. Park, D. Lee, J.H. Chung, K.H. Lee, S.H. Kim, T.W. Jin (Seoul, KR) Effect of valsartan or ramipril addition to amlodipine/hydrochlorotiazide combination on left ventricular hypertrophy in hypertensive patients with type 2 diabetes. – R. Fogari, A. Mugellini, A. Zoppi, P. Preti, G. Derosa (Pavia, IT) Cardiorenal protection by BAY 94-8862, a novel non-steroidal mineralocorticoid receptor antagonist in a preclinical model of hypertension and diastolic heart failure. – M. Delbeck, A. Kretschmer, R. Kast, L. Baerfacker, E. Hartmann, S. Schaefer, P. Kolkhof (Wuppertal, DE) Predictors of adequate response in spironolactone-treated resistant hypertension. – A.D. Javier, M.C. Acelajado, M.C. Acelajado-Valdenor (Manila, PH) P4419 P4420 P4421 P4422 P4423 259 TUESDAY, 28 AUGUST 2012 – MORNING POSTERS The effect life-style education programme together with the telmisartan treatment in patients with essential hypertension. – P. Solik, E. Demesova, P. Lesny, M. Luknar, I. Varga, E. Goncalvesova (Bratislava, SK) Effects of telmisartan on adiponectin and Retinol-Binding Protein 4 in patients with type 2 diabetes. – V. Shishkova, A. Remennik (Moscow, RU) Blood pressure reduction with aliskiren in outpatients with hypertension in real life during 2-year follow-up. Results of the prospective 3A Registry. – U. Zeymer, R. Dechend, E. Deeg, I. Hagedorn, R. Schmieder (Ludwigshafen, Berlin, Nuremberg and Erlangen, DE) P4424 P4425 P4426 PHARMACOLOGY OF HYPERTENSION: MISCELLANEOUS Phytochemical drugs are the new progress in the genetically determined arterial hypertension treatment. – V.I. Zabela, V.V. Shylau, V.Y.U. Afonin (Minsk, BY) Haemodynamic effects of dapagliflozin versus hydrochlorothiazide in subjects with type 2 diabetes mellitus. – H.L. Heerspink, D. De Zeeuw, L. Wei, B.R. Leslie, J.F. List (Groningen, NL; Hopewell and Princeton, US) Coronary artery calcification and ECG pattern of left ventricular hypertrophy or myocardial ischemia identify different healthy subjects at risk. – S.Z. Diederichsen, O. Gerke, M.H. Olsen, J. Lambrechtsen, N.P.R. Sand, B.L. Norgaard, H. Mickley, A.C. Diederichsen (Odense, Svendborg, Esbjerg and Vejle, DK) Five-year target systolic blood pressure less than 120 mmHg for more than 65 aged hypertension patients with chronic renal disease. – X.H. Zeng, Z.H. Liu, Y.Y. Li, X.J. Zeng (Chengdu, CN) Cholesterol control and incident antihypertensive treatment in hypercholesterolemic subjects treated or not with statins: a pharmacoepidemiological report. – A. Cicero, L. Degli Esposti, S. Saragoni, S. Buda, S. Radici, P. Lilli, C. Borghi (Bologna, Ravenna, Piacenza and Foligno, IT) Long-term, open-label treatment with triple olmesartan (O)/amlodipine (A)/hydrochlorothiazide (H) combination therapy in moderate-to-severe hypertension patients (pts). – M. Volpe, B. Ammentorp, P. Laeis (Rome and Pozzilli, IT; Munich, DE) Renoprotective effect of cilnidipine via the antioxidant activity in hypertensive patients. – T. Soeki, M. Kitani, H. Yamada, T. Wakatsuki, T. Kawano, S. Orino, K. Kawano, A. Kakutani, S. Bando, M. Sata (Tokushima, Higashikagawa and Yoshinogawa, JP) Does obstructive sleep apnea affect the right heart in patients with resistant hypertension? Echocardiographic study. – P.P. Dobrowolski, E. Florczak, A. Klisiewicz, A. Prejbisz, P. Bielen, E. Warchol, H. Janaszek-Sitkowska, A. Januszewicz, P. Sliwinski, P. Hoffman (Warsaw, PL) P4427 P4428 P4429 P4430 P4431 P4432 P4433 P4434 NOVEL DIAGNOSTIC AND THERAPEUTIC APPROACHES IN STABLE CORONARY ARTERY DISEASE Utility of high-sensitivity cardiac troponin T in patients undergoing elective coronary angiography. – W. Hochholzer, C.M. Valina, C. Stratz, D. Schlittenhardt, D. Trenk, F.J. Neumann (Bad Krozingen, DE) Evidence of a synergistic impact of polymorphisms on C-reactive protein and interleukin-6 gene in patients with stable angina pectoris: Effect on inflammatory process. – G. Hatzis, D. Tousoulis, A. Miliou, N. Papageorgiou, G. Bouras, G. Latsios, G. Siasos, K. Tsioufis, K. Toutouzas, C. Stefanadis (Athens, GR) Association between increased levels of cardiac troponin before elective stenting and optical coherence tomography findings in stable angina pectoris. – T. Lee, T. Kakuta, T. Murai, T. Iwai, T. Takagi, K. Hishikari, Y. Iesaka (Tsuchiura, JP) Diagnostic performance of cardiac hybrid imaging of single photon emission computed tomography and coronary computed tomography. – M. Nishio, T. Nemoto, M. Asai, K. Kashiwase, K. Matsuo, A. Hirata, Y. Ueda (Osaka, JP) Ivabradine in combination with beta-blocker is more effective than up-titration of beta-blockers in patients with stable angina. – Y.A. Karpov, M.G. Glezer, Y.A. Vasyuk, R.T. Saygitov, E. Shkolnik (Moscow, RU) Influence of coronary plaque compositions on fractional flow reserve and epicardial stenosis resistance. – C. Akdeniz, S. Umman, Y. Nisanci, B. Umman, Z. Bugra, M. Sezer (Istanbul, TR) Plasma cyclophilin A level is a novel biomarker of coronary artery disease. – K. Satoh, Y. Fukumoto, K. Sugimura, Y. Miura, K. Nochioka, T. Aoki, S. Tatebe, Y. Takagi, J. Takahashi, H. Shimokawa (Sendai, JP) Increased rho-kinase activity in patients with vasospastic angina after the great east japan earthquake disaster. – T. Nihei, J. Takahashi, Y. Kikuchi, Y. Ito, R. Tsuburaya, Y. Takagi, M. Nakayama, K. Ito, S. Yasuda, H. Shimokawa (Sendai and Suita, JP) “Heart team” decision making in the management of patients with Coronary Artery Disease; structure, outcomes and reproducibility. – L. Tapp, J. Thekkudan, E. Morris, H. Luckraz, M.S. Norell (Wolverhampton, GB) The appropriate time of intravenous hydration to prevent contrast-induced nephropathy. – S. Namiuchi, T. Sugie, T. Takii, T. Kawaguchi, K. Yamaya, A. Kato (Sendai, JP) Effective radiation dose to obtain coronary morphology and function: comparison of a non-invasive and an invasive strategy. – G. Toth, A. Ntalianis, M. De Booj, S. Pyxaras, L. Di Serafino, F. De Vroey, P. Vanhoenacker, P. De Bondt, W. Wijns, B. De Bruyne (Aalst, BE) 260 P4435 P4436 P4437 P4438 P4439 P4440 P4441 P4442 P4443 P4444 P4445 TUESDAY, 28 AUGUST 2012 – MORNING POSTERS P4446 P4447 P4448 P4449 P4450 P4451 P4452 P4453 P4454 P4455 P4456 P4457 P4458 P4459 P4460 P4461 TUESDAY – MORNING Nearly doubled 5-year-mortality in patients with stable coronary artery disease and prior stroke in clinical practice: results of the Star-Registry. – A.K. Gitt, F. Towae, C. Juenger, A. Papp, R. Zahn, U. Zeymer, J. Senges (Ludwigshafen, DE) Prognostic impact of uric acid in patients with stable coronary artery disease. – G. Ndrepepa, S. Braun, M. Hadamitzky, M. Fusaro, H.U. Haase, K.A. Birkmeier, A. Schomig, A. Kastrati (Munich, DE) Serum vitamin D levels are independently associated with severity of coronary artery disease. – F. Akin, N. Kose, M. Sari, M. Duran, O. Uysal, D. Goldsmith, M. Kanbay (Mugla, Istanbul and Kayseri, TR; London, GB) Lack of concordance between image stress tests and invasive functional evaluation with pressure wire in patients with stable angina. – S.B. Baptista, P. Magno, J.R. Loureiro, M. Nedio, C. Monteiro, E. Lourenco, P. Leal, P.F. Abreu, V. Gil (Amadora, PT) A novel method for the detection of coronary artery disease using an ultrasensitive microphone on the chest wall. – S.E. Schmidt, J.J. Struijk, L.H. Madsen, J. Hansen, H. Zimmermann, H. Moller, D. Hammershoi, E. Toft, H. Kelbaek, P. Clemmensen (Aalborg and Copenhagen, DK) Effects of ranolazine and ivabradine on exercise stress test and on coronary and peripheral vascular function in patients with refractory microvascular angina. – A. Villano, A. Di Franco, R. Nerla, G. Russo, A. Sestito, P. Tarzia, P. Lamendola, F.M. Sarullo, G.A. Lanza, F. Crea (Rome and Palermo, IT) Impact of metabolic syndrome on the outcome of patients with stable coronary artery disease submitted to different types of treatment: 10-year follow-up of the MASS II study. – E.G. Lima, W. Hueb, R. Rahmi, R.D.O. Vieira, C.L. Garzillo, A.C. Pereira, A.C. Hueb, P.C. Rezende, J.A.F. Ramires, R. Kalil Filho (São Paulo, BR) YKL-40 is associated with long-term mortality in patients with stable coronary artery disease. – M. Harutyunyan, P. Winkel, J. Hilden, J.P. Goetze, J.S. Johansen, J.F. Hansen, G.B. Jensen, E. Kjoeller, H.J. Kolmos, J. Kastrup (Copenhagen, Herlev, Hvidovre and Odense, DK) Coronary plaque characteristics that indicate distal embolization during percutaneous coronary intervention in patients with stable angina-virtual histology intravascular ultrasound study. – F. Inoue, T. Fujimoto, H. Oka, K. Ueshima, T. Nakano, K. Fujiki, N. Maruyama, S. Yoshimoto (Nara, JP) Effects of ranolazine and ivabradine on angina status and quality of life in patients with microvascular angina. – A. Villano, A. Di Franco, R. Nerla, G. Russo, A. Sestito, P. Lamendola, A. Di Monaco, F.M. Sarullo, G.A. Lanza, F. Crea (Rome and Palermo, IT) Low testosterone levels correlate with the angiographic extent of coronary artery disease in patients with stable angina and/or abnormal stress test. – N. Ioakeimidis, C. Vlachopoulos, A. Aggelis, D. Terentes-Printzios, A. Synodinos, A. Samentzas, A. Aggelakas, K. Rokkas, K. Aznaouridis, C. Stefanadis (Athens, GR) Markers of prognosis, incidence of sudden cardiac death and heart failure in coronary artery disease. – E. Bobescu, D. Dobreanu, N. Aldulea, A. Covaciu (Brasov and Targu Mures, RO) Extracorporeal shockwave myocardial revascularization therapy (ESMR): an alternative for patients with end-stage coronary artery disease and chronic refractory angina pectoris? – J. Vainer, J. Habets, C. De Pont, A. Lousberg, S. Schalla, B. Brans, J. Waltenberger (Maastricht, NL; Münster, DE) The prevalence of refractory angina in patients undergoing coronary angiography for stable ischemic heart disease. – I.S. Lubchenko, A.A. Doletsky, D.A. Andreev, A.V. Svet, A.L. Syrkin (Moscow, RU) Prognostic value of “tight” blood pressure control in patients with coronary artery disease: evidence from the Action database. – P. Meredith, S. Lloyd, I. Ford, H.L. Elliott (Glasgow, GB) Impact of coronary atherosclerotic burden on clinical presentation and prognosis of patients with coronary artery disease. – G. Ndrepepa, T. Tada, M. Fusaro, L. King, M. Hadamitzky, H.U. Haase, A. Schomig, J. Pache, A. Kastrati (Munich, DE) Non-invasive therapy for management of patients with advanced Coronary Artery Disease. – S.Z. Rasheed, W. Kazmi (Karachi, PK) P4462 UPDATE ON INNATE AND ADAPTIVE IMMUNITY IN CORONARY ARTERY DISEASE Interleukin-6 promoter genetic polymorphism is associated with the presence and the severity of coronary artery disease. – G. Hatzis, D. Tousoulis, N. Papageorgiou, A. Miliou, E. Androulakis, G. Latsios, G. Siasos, A.M. Kampoli, C. Tentolouris, C. Stefanadis (Athens, GR) Lipoprotein-associated phospholipase A2 (Lp-PLA2) bound on high density lipoprotein is associated with lower risk of cardiac death in stable coronary artery disease patients: a three year follow-up. – L. Rallidis, J. Lekakis, I. Rizos, C. Tellis, C. Varounis, D. Barmperis, A. Charalampopoulos, M. Zolindaki, M. Anastasiou-Nana, A. Tselepis (Athens, Ioannina and Piraeus, GR) Peripheral blood monocyte sirt1 expression is reduced in patients with coronary artery disease. – A. Breitenstein, C.A. Wyss, R.S. Spescha, D. Hof, M. Hasun, A. Akhmedov, A. Von Eckardstein, W. Maier, T.F. Luscher, G.G. Camici (Zurich, CH) Memory T cells are related with microvascular obstruction in ST segment acute myocardial infarction. – M.J. Forteza, V. Bodi, I. Trapero, F.J. Chaustre, C. Gomez, I. Benet, J. Sanchis, J.V. Monmeneu, F.J. Chorro (Valencia, ES) P4463 P4464 P4465 P4466 261 TUESDAY, 28 AUGUST 2012 – MORNING POSTERS Patients with acute myocardial infarction and severe obstructive coronary atherosclerosis display distinct peripheral blood gene expression profiles. – D. Aronson, Y. Drier, M. Shmoish, E. Domani, E. Sprecher, S. Nahum (Haifa, Rehovot and Tel Aviv, IL) Role of cd31 and cd38 in innate and adaptive immunity in patients with chronic stable angina and acute coronary syndromes. – D. Flego, A. Severino, A. Giglio, V. Galiffa, F. Trotta, D. Pedicino, M. Previtero, G. Liuzzo, F. Crea (Rome, IT) Erythrocyte aggregation portends worse outcomes in unstable angina patients undergoing Percutaneous Coronary Interventions. – A. Steinvil, B. Shmuel, A. Halkin, G. Keren, A. Finkelstein, N. Mashav, M. Zuzut, S. Berliner, G. Aviram, Y. Arbel (Tel Aviv, IL) Admission white blood cell count predicts acute kidney injury in patients with acute myocardial infarction. – G. Lazaros, D. Tsiachris, A. Patialiakas, A. Kordalis, C. Tsioufis, C. Vlachopoulos, D. Tousoulis, C. Stefanadis (Athens, GR) Elevated plasma high sensitivity C-reactive protein and endothelin are associated with decreased flicker-light induced retinal arteriolar dilatation. – A. Alfiadh, N. Uddin, S.K. Patel, E. Glatz, A.M. Wilson, D.J. Clark, R. Kawasaki, T.Y. Wong, L.M. Burrel, O. Farouque (Melbourne, AU) Myocardial injury induces AIM2 inflammasome expression in neutrophil granulocytes in patients with acute coronary syndrome. – J. Hoffmann, H.M. Nef, L.P. Pyttel, P. Thiele, C. Troidl, C. Liebetrau, S. Szardien, S. Voss, C.W. Hamm, H. Moellmann (Bad Nauheim and Giessen, DE) Monocyte chemoattractant protein-1 release does not respond to acute variations of background inflammation and lipid peroxidation, but it is subjected to circadian variations. – A.S. Antonopoulos, C. Antoniades, M. Demosthenous, D. Tousoulis, K. Marinou, A. Miliou, C. Bakogiannis, C. Psarros, C. Vlachopoulos, C. Stefanadis (Athens, GR) Increased YKL-40 levels in patients with isolated coronary artery ectasia. – T. Erdogan, S.A. Kocaman, M. Cetin, A. Kirbas, M.E. Durakoglugil, A. Canga, A. Yilmaz, Y. Cicek, S. Dogan, M. Bostan (Rize, TR) Functional characteristics of monocytes subsets in the acute and healing phases of ST elevation myocardial infarction and their effect on ejection fraction. – A. Ghattas, G. Lip, H. Griffiths, E. Shantsila (Birmingham, GB) Inflammatory capacity of peri-coronary adipose tissue may affect plaque destabilization in patients with non ST segment myocardial infarction. – T. Mazurek, M. Kobylecka, J. Kochman, K. Filipiak, L. Krolicki, G. Opolski (Warsaw, PL) Infection with human immunodeficiency virus is an independent predictor of increased aortic stiffness. – M. Asaad, O.J. Rider, N. Ntusi, E. Wainwright, A. Pitcher, J. Suttie, K. Clarke, L. Dorrell, S. Neubauer, C. Holloway (Oxford, GB) Low-grade inflammation and post-operative clinical outcome in elective coronary artery bypass surgery: the emerging role of monocyte chemoattractant protein 1. – M. Demosthenous, C. Antoniades, D. Tousoulis, A.S. Antonopoulos, A. Miliou, C. Bakogiannis, C. Psarros, N. Koumallos, N. Sfyras, C. Stefanadis (Athens, GR) Monocyte-derived angiogenic/reparative cells in myocardial infarction: focus on monocyte subpopulations. – E. Shantsila, A.D. Tapp, B.J. Wrigley, A. Shantsila, G.Y.H. Lip (Birmingham, GB) The association of neutrophil/lymphocyte ratio with coronary flow and in-hospital mace in patients with STEMI undergoing primary PCI. – M. Akpek, O. Sahin, D. Elcik, M.G. Kaya (Kayseri, TR) Higher plasma levels of platelet derived growth factor and matrix metalloproteinase-9 in coronary artery in patients with acute myocardial infarction. – T. Koizumi, K. Sugi, J. Tanno, J. Sato, T. Kikutani, S. Nakano, T. Muramatsu, N. Komiyama, S. Nishimura (Hidaka, JP) The impact of hsCRP on acetylcholine induced coronary artery spasm in female patients. – J.Y. Park, Y.S. Chun, S.K. Ryu, J.W. Choi, S.W. Rha, A. Elnagar, S.I. Im, S.W. Kim, C.U. Choi, D.J. Oh (Seoul, KR) Suppression of iron metabolism pathway and improvement of cardiac function by erythropoietin administration in patients with acute myocardial infarction. – M. Oda, K. Toba, K. Kato, T. Ozawa, T. Suzuki, H. Suzuki, N. Tomosugi, Y. Aizawa (Niigata, Yokohama, Kanazawa and Nagaoka, JP) Low T3 syndrome and inflammation in patients with ST-elevation myocardial infarction. – E. Galli, N. Botto, U. Paradossi, A. Mazzone, M. Baroni, C. Palmieri, M. Ravani, A. Clerico, G. Iervasi, S. Berti (Pisa and Massa, IT) High C-reactive protein is a better predictor of occult coronary artery disease than low testosterone in asymptomatic men less than 60 years with erectile dysfunction. – D. Terentes-Printzios, C. Vlachopoulos, N. Ioakeimidis, A. Aggelis, A. Synodinos, P. Xaplanteris, K. Rokkas, A. Samentzas, K. Aznaouridis, C. Stefanadis (Athens, GR) Does the gene expression of transforming growth factor beta1 (TGFbeta1) contributes to the occurrence of acute coronary syndrome (ACS)? – J. Dabek (Katowice, PL) Early cardiac gene transcript levels in peripheral blood mononuclear cells reflect severity in stable coronary artery disease. – J.E. Kontaraki, G.E. Kochiadakis, M.E. Marketou, G. Chlouverakis, N.E. Igoumenidis, I.G. Saloustros, P.E. Vardas (Heraklion, GR) 262 P4467 P4468 P4469 P4470 P4471 P4472 P4473 P4474 P4475 P4476 P4477 P4478 P4479 P4480 P4481 P4482 P4483 P4484 P4485 P4486 P4487 TUESDAY, 28 AUGUST 2012 – MORNING POSTERS Gamma-glutamyltransferase levels are associated with inflammatory activation, myocardial dysfunction and in-hospital mortality in patients with ST-elevation myocardial infarction. – E. Galli, M. Mariani, N. Botto, U. Paradossi, C. Palmieri, A. Taddei, A. Clerico, M. Emdin, G. Iervasi, S. Berti (Pisa and Massa, IT) Predictive incremental value of combination of inflammatory cytokines (IL6-IL10-MIG) on impaired ventricular function at discharge and on 6-month mortality after ST-elevation myocardial infarction. – E. Ammirati, C.V. Cannistraci, N. Cristell, A. Palini, V. Guida, A. Monello, A. Durante, A.A. Manfredi, D. Cianflone, A. Maseri (Milan and Florence, IT; Thuwal, SA) P4488 P4489 UPDATE ON CORONARY SPASM AND MICROVASCULAR DYSFUNCTION P4490 P4491 P4492 P4493 P4494 P4495 P4496 P4497 P4498 P4499 P4500 TUESDAY – MORNING The area of microvascular obstruction after acute myocardial infarction is determined mainly by infarct size and reduced clot permeability. – J. Zalewski, P. Lech, M. Durak, J. Nessler, A. Undas, K. Zmudka (Krakow, PL) Prevalence of microvascular obstruction after primary percutaneous coronary intervention is higher in male patients with hypogonadism. – G. Niccoli, D. D’Amario, D. Milardi, G. Grande, F. Fracassi, C. Carrozza, G. Canu, C. Zuppi, A. Pontecorvi, F. Crea (Rome, IT) Correlation between coronary microvascular function and angina status in patients with stable microvascular angina. – A. Di Franco, A. Di Monaco, P. Lamendola, A. Sestito, A. Villano, G. Russo, F. Infusino, P. Tarzia, G.A. Lanza, F. Crea (Rome, IT) Effect of short-acting nitrates on exercise stress test and coronary microcirculation in patients with microvascular angina. – G. Russo, A. Di Franco, P. Lamendola, A. Di Monaco, R. Nerla, A. Villano, P. Tarzia, A. Sestito, G.A. Lanza, F. Crea (Rome, IT) The index of microcirculatory resistance was strongly associated with infarct size only in anterior ST-segment elevation myocardial infarction, but not in non-anterior STEMI. – H. Shibata, N. Ito, A. Tsuruoka, Y. Kurozumi, N. Yamada, T. Natsukawa, K. Okada, H. Sawano, Y. Doi, T. Hayashi (Suita, JP) Quantitative analysis of microvascular obstruction is bestly related to clinical prognosis than clinical markers at a 1 year follow-up: a contrast-enhanced MRI study. – L. Biere, M. Le Nezet, G. Clerfond, V. Mateus, S. Grall, J. Jeanneteau, F. Prunier, S. Willoteaux, A. Furber (Angers, FR) Coronary microvascular function is impaired in diabetic patients with normal coronary arteries and correlates to renal function. – C. Marciano, M. Galderisi, C. D’Amore, R. Esposito, P. Gargiulo, L. Casaretti, R. Formisano, F. Lo Iudice, M. Cecere, P. Perrone Filardi (Naples, IT) The Impact of ECG Change during Intracoronary Acetylcholine Provocation test on the 12 months Clinical Outcomes in Korean patients. – S.W. Rha, J.Y. Park, S.K. Ryu, J.W. Choi, B.G. Choi, A. Elnagar, S.I. Im, S.W. Kim, C.U. Choi, D.J. Oh (Seoul, KR) Association of myocardial bridge and acetylcholine induced coroanry artery spasm and 12-months clinical outcomes. – S.W. Rha, J.Y. Park, S.K. Ryu, J.W. Choi, B.G. Choi, A. Elnagar, S.I. Im, S.W. Kim, C.U. Choi, D.J. Oh (Seoul, KR) Twelve months clinical outcomes of diffuse coronary artery spasm as compared with focal coronary artery spasm. – S.Y. Choi, S.W. Rha, A. Elnagar, S.I. Im, S.W. Kim, S.W. Han, C.U. Choi, C.G. Park, H.S. Seo, D.J. Oh (Seoul, KR) Impact of alcohol on coronary artery spasm as assessed with intracoronary acetylcholine provocation test. – S.W. Rha, B.G. Choi, A. Elnagar, S.I. Im, S.W. Kim, C.U. Choi, J.W. Kim, C.G. Pak, H.S. Seo, D.J. Oh (Seoul, KR) CONDITIONING AND OXYDATIVE STRESS: FROM BENCH TO PRACTICE Exendin-4 postconditioning is not effective in hearts isolated from hypertensive SHR-SP rats with left ventricular hypertrophy. – B. Faricelli, M. Salomonsson, A. Consoli, T. Engstroem, M. Treiman (Copenhagen, DK; Chieti, IT) Impact of ischemic postconditioning in acute myocardial infarction patients with preconditioning. – T. Takeuchi, H. Ota, Y. Ishii, N. Hasebe (Asahikawa, JP) Second window and chronic remote ischemic conditioning prevent endothelial injury by ischemia-reperfusion in humans. – K. Pryds, S. Rasalingam, H. Contractor, M.R. Schmidt, R.K. Kharbanda, H.E. Botker (Aarhus, DK; Oxford, GB) Effect of hydrogen gas inhalation on lipid metabolism and left ventricular remodeling induced by intermittent hypoxia in mice. – S. Nishioka, T. Yoshioka, M. Ohkita, Y. Matsumura, N. Ishizaka, Y. Okada, T. Hayashi (Takatsuki, JP) APE1/Ref-1 decreases ROS generation and myocardial infarction in a mouse model of acute myocardial infarction. – J.O. Jeong, S.A. Jin, S.J. Park, J.H. Park, J.Y. Yoon, S.K. Kim, S.W. Choi, J.H. Kim, B.H. Jeon, I.W. Seong (Daejeon, KR) P4501 P4502 P4503 P4504 P4505 263 TUESDAY, 28 AUGUST 2012 – MORNING POSTERS Effect of sildenafil on mitochodria in rat myocardial infarction model - morphological and property changes utilizing atomic force microscopy. – W. Kim, K.H. Lee, S.R. Lee, H.H. Jang, H.S. Kim, J.S. Woo, G.J. Lee, H.K. Park (Seoul, KR) P4506 DIASTOLIC DYSFUNCTION: EPIDEMIOLOGY AND MECHANISM Prevalence and incidence of myocardial dysfunction and chronic heart failure in the patients with type 1 diabetes: a 7-year prospective cohort study. – E. Parnicka-Konduracka, M. Malecki, D. Galicka-Latala, G. Gajos, P. Rostoff, A. Pietrucha, J. Nessler (Krakow, PL) Prevalence, correlates and prognostic significance of QRS prolongation in heart failure with reduced and preserved ejection fraction. – L.H. Lund, J. Jurga, M. Edner, L. Benson, U. Dahlstrom, C. Linde, U. Alehagen (Stockholm and Linköping, SE) Prevalence of increased heart rate, links with clinical status and therapy in outpatients with heart failure with preserved ejection fraction in modern Poland: results of preserved-DATA-HELP study. – E.A. Jankowska, B. Kurian, W. Banasiak, P. Ponikowski (Wroclaw and Warsaw, PL) Old tools in new combination: combined stress echocardiography cardiopulmonary exercise testing in early detection of diastolic dysfunction. – I. Nedeljkovic, M. Ostojic, V. Giga, J. Stepanovic, A. Djordjevic-Dikic, V. Stojanov, B. Parapid, S. Mazic, M. Petrovic, M. Beleslin (Belgrade, RS) Anthracycline cardiotoxicity: incidence at present time. – J.M. Serrano, C. Cristobal, C. Graupner, R.M. Jimenez, A. Curcio, L. Morales, M. Luaces, P. Talavera, J. Guerra, J. Alonso (Fuenlabrada, ES) Relation between diastolic function in rest and during stress and peak exercise capacity among heart transplant recipients. – T. Monk-Hansen, C. Have Dall, S. Bisgaard Christensen, M. Snoer, H. Rasmusen, F. Gustafsson, E. Prescott (Copenhagen and Gentofte, DK) Diastolic dysfunction is associated with reduced exercise capacity in non-obese subjects. Results from a population-based study sample. – M. Dorr, A. Hummel, T. Reffelmann, S. Glaeser, C. Schaeper, B. Koch, H. Volzke, R. Ewert, S.B. Felix (Greifswald, DE) The association between computed tomography-derived three-dimensional pericardial adipose burden, cardiac structural alteration and diastology. – Y.H. Lai, C.H. Yun, C.H. Yen, Y.J. Wu, J.Y. Kuo, H.I. Yeh, C.L. Hung (Taipei and New Taipei, TW) Strong association between cardiac fatty acid uptake using BMIPP and abnormalities in diastolic left ventricular function in diabetic patients with heart failure. – T. Hashizume, S. Shioji, T. Akasaka (Tanabe and Wakayama, JP) A risk-factor based porcine model of heart failure with preserved ejection fraction (HFPEF). – M. Schwarzl, S. Seiler, P. Steendijk, B. Pieske, H. Post (Graz, AT; Leiden, NL) P4507 P4508 P4509 P4510 P4511 P4512 P4513 P4514 P4515 P4516 HEART FAILURE WITH PRESERVED EJECTION FRACTION-ECHO INVESTIGATION The relation between left atrial systolic function and left ventricular performance in heart failure with preserved ejection fraction. – Y.J. Lim, S. Kawano, H. Nanmori, M. Takeuchi (Higashiosaka, JP) Radial ventricular dyssynchrony on exercise in patients with heart failure and normal ejection fraction. – F.W.G. Wenzelburger, Y.T. Tan, F. Leyva, J.E. Sanderson (Stoke On Trent and Birmingham, GB; Hong Kong, HK) Prognostic significance of calibrated integrated backscatter in patients with heart failure and preserved ejection fraction. – B.D. Here, D. Stepowski, C. Vallet, B. Kurtz, V. Richard, J.N. Dacher, H. Eltchaninoff, F. Bauer (Rouen, FR) Left but not right ventricular diastolic function deteriorates during follow up in patients with systemic sclerosis. – M. Ciurzynski, P. Bienias, K. Irzyk, K. Kurnicka, B. Lichodziejewska, M. Kostrubiec, Z. Rymarczyk, A. Szewczyk, M. Siwicka, P. Pruszczyk (Warsaw, PL) Left ventricular torsion during exercise in patients with and without increase in left ventricular filling pressures. – G. Barge-Caballero, J. Peteiro, A. Bouzas-Mosquera, A. Lopez-Sainz, M. Lopez-Perez, O. Prada, A. Castro-Beiras (A Coruña, ES) Ventricular-arterial coupling and arterial stiffness in hypertensive subjects with diastolic heart failure. – I. Goncharov, R. Akhmetov, L. Alexandria, Y. Kotovskaya, S. Villevalde (Moscow, RU) Moving toward an ejection fraction paradox: the ratio between left ventricular and left atrial volume. – P. Pellicori, A. Bennett, O. Khaleva, A. Torabi, P. Costanzo, E. Wright, K. Wong, A.L. Clark, J.G.F. Cleland (Hull, GB) Deceleration time of early diastolic velocity by tissue Doppler velocity image: a novel index of left ventricular end-diastolic pressure. – K. Takemoto, K. Hirata, K. Ishibashi, T. Yamano, T. Tanimoto, Y. Ino, T. Yamaguchi, T. Kubo, T. Imanishi, T. Akasaka (Wakayama, JP) Impact of gender difference on the relation between arterial stiffness and left ventricular diastolic function in healthy subjects. – M. Saito, H. Okayama, H. Higashi, H. Morioka, T. Yoshii, G. Hiasa, T. Sumimoto, K. Nishimura, K. Inoue, J. Higaki (Ozu, Matsuyama and Toon, JP) 264 P4517 P4518 P4519 P4520 P4521 P4522 P4523 P4524 P4525 TUESDAY, 28 AUGUST 2012 – MORNING POSTERS Increased prevalence of diastolic heart failure can be identified by impaired global longitudinal strain in patients with rheumatoid arthritis. – T. Schau, M. Zaenker, M. Schoepp, D. Rijab, M. Neuss, J. Meyhoefer, C. Butter (Bernau bei Berlin, DE) Diagnostic of heart failure with normal ejection fraction in outpatients: usefulness of european society of cardiology guideline. – A.J. Lagoeiro Jorge, M.L. Ribeiro, L.C.M. Fernandes, M.C. Freire, E.T. Mesquita (Niterói, BR) Diastolic filling pressures, a valuable tool in the detection of acute allograft rejection in heart transplantation. – M. Sanchez Garcia, S. Mingo Santos, V. Monivas Palomero, I. Garcia Lunar, E. Gonzalez Lopez, P. Beltran Correas, C. Mitroi, M. Gomez Bueno, J. Segovia Cubero, L.A. Alonso Pulpon (Madrid, ES) P4526 P4527 P4528 DISTAOLIC DYSFUNCTION AND TREATMENT Differing relations of the clinical responder rate to the left ventricular reverse remodelling and changes in left ventricular filling pattern in patients receiving cardiac resynchronization therapy. – M. Dekany, G. Zoltan, B. Szabo, B. Muk, B. Ancsin, T. Borsanyi, G.Z. Duray, R.G. Kiss, N. Nyolczas (Budapest, HU) Creatine Phosphate Sodium combining with fractose diphosphate for injection on severe diastolic heart failure. – X. Zeng, Y.Y. Li, X.J. Zeng, A.Y. Tu, Z.H. Liu (Chengdu, CN) Diastolic function improves after resolution of takotsubo cardiomyopathy. – S. Kumar, M. Waldenborg, P. Bhumireddy, K. Ramkissoon, A.L. Innasimuthu, K. Loiske, K. Emilsson, J.M. Lazar (New York and Brooklyn, US; Örebro, SE) A low glycemic and insulinemic diet improves diastolic cardiac function and metabolic syndrome more than the traditional low-fat diet in overweight patients with type 2 diabetes. – H. Von Bibra, G. Wulf, T. Schuster, A. Pfuetzner, P. Heilmeyer (Munich, Isny and Mainz, DE) Adaptive servo ventilation improves long-term prognosis in heart failure patients with preserved left ventricular ejection fraction and sleep disordered breathing. – S. Suzuki, A. Yoshihisa, M. Miyata, T. Yamaki, K. Sugimoto, H. Kunii, K. Nakazato, H. Suzuki, S. Saitoh, Y. Takeishi (Fukushima, JP) P4529 P4530 P4531 P4532 P4533 HEART FAILURE WITH PRESERVED EJECTION FRACTION: BIOMARKERS Serum cystatin C as a biomaker of cardiac diastolic dysfunction in patients with cardiac disease and preserved ejection fraction. – K. Nosaka, K. Nakamura, K.F. Kusano, T. Tada, T. Miyoshi, M. Doi, K. Kohno, H. Morita, H. Ito (Takamatsu and Okayama, JP) Serum vitamin D and CRP levels are independently associated with diastolic dysfunction. – F. Akin, N. Kose, M. Sari, M. Duran, O. Uysal, D. Goldsmith, M. Kanbay (Mugla, Istanbul and Kayseri, TR; London, GB) Dissecting the mechanisms of left ventricular diastolic dysfunction and inflammation in continuous ambulatory peritoneal dialysis patients. – C. Wu, Y.-T. Huang, J. Lee (Taipei and New Taipei City, TW) Pulmonary hypertension and collagen metabolism in patients with heart failure and preserved ejection fraction. – M. Farrero Torres, E. Santiago, M. Batlle, I. Blanco, G. Kasa, M. Cardona, M.A. Castel, J.A. Barbera, F. Perez Villa (Barcelona, ES) Expression of connective tissue growth factor in diastolic heart failure patients and canine models. – C. Wu, Y. Wang, J. Lee, C. Tsai, F. Chiang (Taipei, TW) P4534 P4535 P4536 P4537 P4538 PHARMACOTHERAPY P4539 TUESDAY – MORNING Resveratrol, a SIRT1 activator, prevents cardiomyopathy in dystrophin-deficient mice by down-regulation of p300. – A. Kuno, M. Tanno, T. Miki, S. Ishikawa, Y. Horio, T. Miura (Sapporo, JP) Continuous infusion of the novel chimeric natriuretic peptide cenderitide in the dahl salt sensitive rat model of hypertension and renal dysfunction: evidence for renoprotection. – M. Schiltgen, A. Walsh, D. Evans, H. Lieu, J.C. Burnett (Minneapolis, San Mateo and Rochester, US) Reduction in hospitalization for worsening of heart failure with ivabradine in patients with chronic systolic heart failure in the SHIFT trial. – J.S. Borer, M. Böhm, I. Ford, M. Komajda, L. Tavazzi, J. Lopez Sendon, M. Alings, E. Lopez De Sa, K. Swedberg, on behalf of the Shift Investigators (New York, US; Homburg, DE; Glasgow, GB; Paris, FR; Cotignola, IT; Madrid, ES; Breda, NL; Gothenburg, SE) Antibodies to C-ending (intracellular) fragment of the angiotensin II type 1 receptor and endothelial NO synthase in patients with congestive heart failure: first clinical exerience. – T.Y. Spitsina, T.H. Temirsultanova, O.V. Ilyukhin, Y.M. Lopatin (Volgograd, RU) Systematic review of the proportion of heart failure patients reporting side effects of beta-blockers in whom the medication is genuinely causative: ethical implications for informed consent. – N. Zaman, A.J. Barron, G.D. Cole, R. Wensel, D.O. Okonko, D.P. Francis (London, GB) Tranilast reduces pathological cardiac fibrosis and improves diastolic function following kidney dysfunction: implication for cardio-renal syndrome. – M. Watanabe, F. See, A. Kompa, B. Wang, S. Lekawanvijit, A. Boyle, R. Gilbert, K. Connelly, D. Kelly, H. Krum (Melbourne, AU; New York and San Francisco, US; Toronto, CA) P4540 P4541 (W) P4542 P4543 P4544 265 TUESDAY, 28 AUGUST 2012 – MORNING POSTERS Reno-protecitve and diuretic therapy with low doses of natriuretic peptide and dopamine in acute heart failure patients. – M. Kamiya, N. Sato, A. Nozaki, M. Akiya, H. Okazaki, Y. Takahashi, K. Mizuno (Tokyo, JP) Decreased mortality and development of heart failure after first-time myocardial infarction between 1997-2009, a danish nationwide cohort study. – A. Gjesing, C. Andersson, L. Kober, G. Gislason, C. Torp-Pedersen (Copenhagen, DK) Cardiac iron and function by CMR in thalassemia major patients treated with combined deferiprone and desferrioxamine regimen versus monotherapies: a multi-center, observational and prospective study. – A. Pepe, A. Meloni, G. Rossi, G.B. Ruffo, D.G. D’Ascola, M. Santodirocco, C. Tudisca, L. Gulino, M. Lombardi, P. Ricchi (Pisa, Palermo, Reggio Calabria, San Giovanni Rotondo and Naples, IT) Evaluation of safety, tolerability, PK and hemodynamic properties of JNJ- 39588146 (stresscopin) in healthy and HF subjects: a phase 1 ascending dose randomized multicenter trial. – A. Olson, V. Conraads, B. Wollaert, J. Di, J. Jiang, O. Bueno, D. Polidori, P. Gengo, M. Lu, N. Shankley (La Jolla, US; Antwerp, BE) Should we achieve the target doses of beta-blockers in chronic heart failure patients with adequate heart rate control? – K. Leemasawat, A. Phrommintikul, R. Kanjanavanit, W. Wongcharoen, K. Okonogi, L. Yongsmith, S. Yooprasert, A. Sukonthasarn (Chiang Mai, TH) Effect of aldosterone antagonism on ejection fraction and exercise capacity is independent of NYHA classification: a meta-analysis of 1575 patients in randomized controlled trials. – D. Phelan, P. Thavendiranathan, P. Collier, T. Marwick (Cleveland, US) Management of acute heart failure and adherence to guidelines in different clinical presentations. – T. Tarvasmaki, V.P. Harjola, K. Siirila-Waris, J. Tolonen, M.S. Nieminen, J. Lassus (Helsinki, FI) Continuous furosemide infusion versus furosemide mannitol infusion in acute congestive heart failure. – M. Turagam, P. Velagapudi, V.S. Hanumanthu, A. Kocheril, J. Holley (Milwaukee, Madison, Boston and Urbana, US) Zofenopril and ramipril plus ASA in post-myocardial infarction patients with left ventricular systolic dysfunction: a post-hoc analysis in preserved or impaired left ventricular fraction at entry. – C. Borghi, E. Ambrosioni (Bologna, IT) Treatment effect versus selection bias in systolic heart failure patients receiving higher target doses of ACE inhibitors: Insights from Studies of Left Ventricular Dysfunction (SOLVD) treatment trial. – A. Ahmed, B. Pitt, G.S. Filippatos, I.B. Aban, P. Deedwania, G.C. Fonarow, D.E. Forman, M. Gheorghiade, W.S. Aronow, R.C. Bourge (Birmingham, Ann Arbor, Fresno, Los Angeles, Boston, Chicago and Valhalla, US; Athens, GR) Statin therapy and clinical outcomes in acute heart failure patients complicating acute myocardial infarction: insights from the EPHESUS trial. – D. Dobre, P. Rossignol, Y. Murin, A. Parkhomenko, Z. Lamiral, H. Krum, D.J. Van Veldhuisen, B. Pitt, F. Zannad (Nancy, FR; Bratislava, SK; Kiev, UA; Melbourne, AU; Groningen, NL; Ann Arbor, US) Efficacy of ivabradine therapy on right heart parameters and prognosis in patients with severe systolic chronic heart failure. – L.R. Tumasyan, K.G. Adamyan, A.L. Chilingaryan (Yerevan, AM) Subcutaneous furosemide can prevent hospitalization in fluid overload decompensation of chronic heart failure. – E. Zatarain Nicolas, J. Lopez Diaz, H. Garcia Pardo, C. Ortiz Bautista, A. Recio Platero, I.J. Amat Santos, M.G. Sandin Fuentes, L. De La Fuente Galan, A. San Roman Calvar (Valladolid, ES) Are there relationships between high resting heart rate and not optimal doses of beta-blockers in outpatients with systolic heart failure in contemporary Poland? Results of DATA-HELP study. – E.A. Jankowska, B. Kurian, W. Banasiak, P. Ponikowski (Wroclaw and Warsaw, PL) Eplerenone and new-onset diabetes in patients with mild heart failure. – D. Preiss, D.J. Van Veldhuisen, H. Krum, K. Swedberg, H. Shi, J. Vincent, S.J. Pocock, B. Pitt, F. Zannad, J. McMurray (Glasgow and London, GB; Groningen, NL; Melbourne, AU; Gothenburg, SE; New York and Ann Arbor, US; Nancy, FR) Do early and late nephroprotective effects differ with different inhibitors of renin-angiotensin-aldosteron system in chronic heart failure patients? – O.V. Tsygankova, D. Platonov, Z.G. Bondareva, I.V. Arutyunyan (Novosibirsk and Tver, RU) Effect of valsartan and amlodipine on heart failure and left ventricular mass in japanese hypertensive patients with glucose intolerance: a subanalysis of the Nagoya heart study. – T. Nagahiro, T. Kondo, K. Yamashita, T. Muramatsu, K. Matsushita, K. Maeda, S. Shintani, T. Murohara (Nagoya, JP) Effects of oral administration of orodispersible L-Carnosine in patients with chronic heart failure and severe left ventricular dysfunction. – C. Lombardi, V. Carubelli, C. Ciccarese, A. Castrini, V. Lazzarini, B. Piovanelli, E. Vizzardi, S. Nodari, M. Metra, L. Dei Cas (Brescia, IT) 266 P4545 P4546 P4547 P4548 P4549 P4550 P4551 P4552 P4553 P4554 P4555 P4556 P4557 P4558 P4559 (W) P4560 P4561 P4562 TUESDAY, 28 AUGUST 2012 – LUNCH TIME SESSIONS 12:45–13:30 | Tbilisi - Central Village MEET THE GUIDELINES TASK FORCE III The Committee for Practice Guidelines Special Session Chairperson(s): J.J. Bax (Leiden, NL); U. Sechtem (Stuttgart, DE) 12:45 13:07 Valvular heart disease: questions and answers to the panellists. – A. Vahanian (Paris, FR), O. Alfieri (Brescia, IT), M.A. Borger (Leipzig, DE), P. Lancellotti (Liège, BE) Atrial fibrillation focused update: questions and answers to the panellists. – A.J. Camm (London, GB), G. Hindricks (Leipzig, DE), S.H. Hohnloser (Frankfurt, DE), G.Y.H. Lip (Birmingham, GB) 4563 4564 12:45–13:30 | Tirana - Central Village MEET THE TRIALIST V: THE GREAT EAST JAPAN EARTHQUAKE DISASTER AND CARDIOVASCULAR DISEASES Meet the Trialists Chairperson(s): G. Steinbeck (Munich, DE) 12:45 The Great East Japan Earthquake Disaster and Cardiovascular Diseases. – H. Shimokawa (Sendai, JP) 4565 12:45–13:45 | Zagreb - Village 2 ESC GENERAL ASSEMBLY Special Event 13:00–14:00 | Beirut - Village 1 THE HEART OF THE MATTER: ARRHYTHMIAS IN WOMEN AND MINIMIZING RADIATION RISKS Sponsored by EPIC Alliance Satellite Symposium Chairperson(s): J. Poole (Seattle, US); C. Blomstrom-Lundqvist (Uppsala, SE) 13:00 13:10 13:25 13:40 13:55 Introduction. – J. Poole (Seattle, US) Gender differences in heritable disorders. – S.G. Priori (Pavia, IT) Working on in the electrophysiology lab: radiation risks to you and your patients. – S. Ernst (London, GB) Incidence of ventricular arrhythmias in women and cardiovascular implantable electronic devices benefit. – A. Russo (Moorestown, US) Research applications - A gender related difference in approvals? – C. Blomstrom-Lundqvist (Uppsala, SE) 4566 4567 4568 4569 4570 13:00–14:30 | Algiers - Village 2 CHANGING PARADIGMS IN THE MANAGEMENT OF RECENT ONSET ATRIAL FIBRILLATION Sponsored by MSD Satellite Symposium 13:05 13:25 13:50 14:15 14:25 Welcome and opening remarks. – P. Kirchhof (Birmingham, GB) Unmet needs in the pharmacological cardioversion of atrial fibrillation: the perspective of an electrophysiologist. – J.R. Ehrlich (Frankfurt, DE) Vernakalant: conversion of atrial fibrillation in patients with ischemic heart disease. – C. Torp-Pedersen (Hellerup, DK) Real-life experience with vernakalant: a swedish cohort. – S. Juul-Moller (Malmo, SE) Panel discussion and Q&A session. – P. Kirchhof (Birmingham, GB) Closing remarks. – C. Torp-Pedersen (Hellerup, DK) TUESDAY – LUNCH TIME Chairperson(s): P. Kirchhof (Birmingham, GB); C. Torp-Pedersen (Hellerup, DK) 13:00 4571 4572 4573 4574 4575 4576 267 TUESDAY, 28 AUGUST 2012 – LUNCH TIME SESSIONS 13:00–14:30 | Berlin - Village 2 EV-077: A NOVEL APPROACH TO VASCULAR INFLAMMATION Sponsored by Evolva Satellite Symposium Chairperson(s): L.C. Wallentin (Uppsala, SE); J. Weitz (Ontario, CA) 13:00 13:10 13:25 13:35 13:45 14:00 Unmet medical need: the overlooked therapeutic potential of thromboxane receptor antagonism. – J. Weitz (Ontario, CA) Vascular inflammation drives atherothrombosis. – K. Sakariassen (Biella, IT) Effects of thromboxane receptor antagonism on platelet reactivity in type 2 diabetics on treatment with aspirin or clopidogrel. – M. Cattaneo (Milan, IT) Antagonism of thromboxane receptor inhibits vascular inflammation: effects on endothelial cells & vascular smooth muscle cells. – M. Back (Stockholm, SE) First clinical results with EV-077: proof of concept study in type 2 diabetics & epidemiological background. – N. Bender (Bad Duerkheim, DE) Roundtable discussion. Potential role of thromboxane receptor antagonism in reduction of vascular inflammation and its medical consequences. Stand alone treatment or adjunct to existing therapy? – L.C. Wallentin (Uppsala, SE), J. Weitz (Ontario, CA), K. Sakariassen (Biella, IT), M. Cattaneo (Milan, IT), M. Back (Stockholm, SE), N. Bender (Bad Duerkheim, DE), P. Fontana (Geneva, CH), J.-M. Dogne (Namur, BE) 4577 4578 4579 4580 4581 4582 13:00–13:45 | Athens - Village 3 FROM EARLY DIAGNOSIS TO LONG TERM MANAGEMENT OF PULMONARY ARTERIAL HYPERTENSION PATIENTS: LEARNING FROM EXPERIENCE Sponsored by GSK Satellite Symposium Chairperson(s): J.S.R. Gibbs (London, GB); J.L. Vachiery (Brussels, BE) 13:00 13:20 13:35 Academic lecture: Management of functional class II patients: what is the evidence. – N. Galie (Bologna, IT) Clinical case: Management of functional class II patient through a real life case. – J.L. Vachiery (Brussels, BE) Panel discussion. – J.S.R. Gibbs (London, GB), J.L. Vachiery (Brussels, BE) 4583 4584 4585 13:00–14:00 | Nicosia - Village 3 IMPACT OF GLUCOSE-LOWERING DRUGS ON CARDIOVASCULAR ENDPOINTS - BENEFIT, NEUTRALITY OR HARM? Organised by the Sahlgrenska Academy - Gothenburg University Course Director: Prof. Karl Swedberg (Gothenburg, SE) EBAC Accredited Educational Programme Chairperson(s): L. Ryden (Stockholm, SE); I. Raz (Jerusalem, IL) 13:00 13:05 13:22 13:39 13:56 Welcome and introduction. – I. Raz (Jerusalem, IL) Effects of established glucose lowering drugs on cardiovascular risk. – L. Ryden (Stockholm, SE) Cardiovascular profile of incretin modulators and sodium-glucose cotransporter 2 inhibitors. – J. Wilding (Liverpool, GB) Outcomes trials with newer glucose-lowering drugs. – I. Raz (Jerusalem, IL) Concluding remarks. – L. Ryden (Stockholm, SE) 4586 4587 4588 4589 4590 “This educational programme is accredited by the European Board for Accreditation in Cardiology (EBAC) for one hour of External CME credits. Each participant should claim only those hours of credit that have actually been spent in the educational activity. EBAC works in cooperation with the European Accreditation Council for Continuing Medical Education (EACCME), which is an institution of the European Union of Medical Specialists (UEMS).” Programme supported by an unrestricted educational grant from AstraZeneca and Bristol-Myers Squibb 268 TUESDAY, 28 AUGUST 2012 – LUNCH TIME SESSIONS 13:00–14:30 | Budapest - Village 4 THE EVOLVING ROLE OF HIGH-DENSITY LIPOPROTEIN IN THE SECONDARY PREVENTION OF HIGH RISK PATIENTS WITH CARDIOVASCULAR DISEASE Sponsored by Cleveland Clinic Satellite Symposium Chairperson(s): S.J. Nicholls (Adelaide, AU); A.M. Lincoff (Cleveland, US) 13:00 13:15 13:30 13:45 14:00 14:25 Rationale for targeting high-density lipoprotein: setting the stage. – S.E. Nissen (Cleveland, US) Apolipoprotein 1 induction: genetic regulation of atherosclerosis. – J.J.P. Kastelein (Amsterdam, NL) Cholesterylester transfer protein inhibition: finding the sweet spot. – B. Brewer (Potomac, US) Potent cholesterylester transfer protein inhibition: is bigger better. – S.J. Nicholls (Adelaide, AU) Question and answer. – All Speakers Final thoughts. – A.M. Lincoff (Cleveland, US) 4591 4592 4593 4594 4595 13:00–14:30 | Prague - Village 4 BENEFITS OF HIGHLY PURIFIED EPA/DHA ETHYL ESTERS ON CARDIOVASCULAR HEALTH IN HIGH RISK PATIENTS Sponsored by Abbott EPD Satellite Symposium Chairperson(s): D. Vinereanu (Bucharest, RO); G. Kolovou (Athens, GR) 13:00 13:05 13:30 13:55 14:20 Cardiovascular health. – D. Vinereanu (Bucharest, RO) Cardiovascular health in high risk patient groups- how highly purified EPA/DHA ethyl esters can help to manage it. – D. Vinereanu (Bucharest, RO) Treatment options for dyslipidemia in high risk patients. – G. Kolovou (Athens, GR) Differences in EPA/DHA formulations and their importance for the treatment of cardiovascular risk. – H. Rupp (Marburg, DE) Closing remarks. – All Speakers 4596 4597 4598 4599 13:00–13:45 | Copenhagen - Village 5 LEFT ATRIAL APPENDAGE CLOSURE (LAAC) FOR STROKE PREVENTION: REASONS TO CONSIDER A DEVICE ALTERNATIVE Sponsored by Boston Scientific Satellite Symposium Chairperson(s): H. Sievert (Frankfurt, DE) 13:03 13:18 13:30 13:42 Introduction. – H. Sievert (Frankfurt, DE) LAAC with WATCHMAN device: latest clinical evidence. – V.Y. Reddy (New York, US) Patient selection considerations. – H. Sievert (Frankfurt, DE) 2012 ESC guidelines perspective. – M. Glikson (Ramat Gan, IL) Program closing and final thoughts. – H. Sievert (Frankfurt, DE) 4600 4601 4602 TUESDAY – LUNCH TIME 13:00 4603 4604 13:00–14:00 | Cairo - Village 6 OPTIMAL MANAGEMENT OF PULMONARY ARTERIAL HYPERTENSION PATIENTS: ARE WE THERE YET? A CASE-BASED APPROACH Sponsored by Pfizer Ltd Satellite Symposium Chairperson(s): N. Galie (Bologna, IT); M. Delcroix (Leuven, BE) 13:00 13:05 13:20 13:40 13:55 Welcome and introduction. – M. Delcroix (Leuven, BE) What is the best way to assess the quality of life of pulmonary arterial hypertension patients? – M. Delcroix (Leuven, BE) Putting theory into practice: a case-based discussion. – M. Humbert (Clamart, FR) Goal-oriented treatment strategies: which goal for which patient? – N. Galie (Bologna, IT) Closing summary. – N. Galie (Bologna, IT) 4605 4606 4607 4608 4609 269 TUESDAY, 28 AUGUST 2012 – LUNCH TIME SESSIONS 13:00–14:00 | Helsinki - Village 8 MAXIMIZE THE RESPONSE OF CARDIAC RESYNCHRONIZATION THERAPY Sponsored by Medtronic Satellite Symposium Chairperson(s): J.G.F. Cleland (Kingston-upon-Hull, GB); S. Favale (Bari, IT) 13:00 13:05 13:20 13:35 13:50 Introduction. – J.G.F. Cleland (Kingston-upon-Hull, GB) Which patients benefit from cardiac resynchonization therapy? – P. Mabo (Rennes, FR) Automatic therapy adaptation to individual patient needs. – S. Faerestrand (Bergen, NO) Innovative tools to improve cardiac resynchronization therapy response at follow-up. – M.G. Scheffer (Rotterdam, NL) Conclusion. – S. Favale (Bari, IT) 4610 4611 4612 4613 4614 13:00–14:00 | Paris - Village 9 DRUG ELUTING STENTS (DES); LATE STENT THROMBOSIS; PROTECT RANDOMIZED TRIAL Sponsored by Medtronic Satellite Symposium Chairperson(s): E. Camenzind (Geneva, CH); P.G. Steg (Paris, FR) 13:00 13:05 13:15 13:25 13:35 13:45 Introduction. – P.G. Steg (Paris, FR) Stent thrombosis; the landscape. – E. Camenzind (Geneva, CH) “PROTECT” results. – P.G. Steg (Paris, FR) “PROTECT” in perspective. – L. Mauri (Boston, US) Lessons learned. – S. Windecker (Berne, CH) Discussion. – P.G. Steg (Paris, FR) 4615 4616 4617 4618 4619 4620 13:00–14:30 | London & The Hague - Village 10 OPTIMIZING HEART FAILURE MANAGEMENT Organised by the Universitätsklinikum Des Saarlandes Course Director: Prof. Michael Böhm (Homburg/Saar, DE) EBAC Accredited Educational Programme Chairperson(s): K. Swedberg (Gothenburg, SE); J.S. Borer (New York, US) 13:00 13:05 13:20 13:35 13:50 14:20 Introduction. – K. Swedberg (Gothenburg, SE) New clinical perspective derived from SHIFT. – J.S. Borer (New York, US) New heart failure Guidelines: therapeutic role of ivabradine. – J.J.V. McMurray (Glasgow, GB) Benefits of Ivabradine in heart failure: how and why. – M. Böhm (Homburg/Saar, DE) Panel discussion: the role of ivabradine in the medical therapy of coronary artery disease and heart failure. – M. Böhm (Homburg/Saar, DE), J.S. Borer (New York, US), M.R. Cowie (London, GB), V. Mareev (Moscow, RU), M. Pfeffer (Boston, US), K. Swedberg (Gothenburg, SE) Conclusion. – J.S. Borer (New York, US) 4621 4622 4623 4624 4625 4626 “This educational programme is accredited by the European Board for Accreditation in Cardiology (EBAC) for one hour of External CME credits. Each participant should claim only those hours of credit that have actually been spent in the educational activity. EBAC works in cooperation with the European Accreditation Council for Continuing Medical Education (EACCME), which is an institution of the European Union of Medical Specialists (UEMS).” Programme supported by an unrestricted educational grant from SERVIER 270 TUESDAY, 28 AUGUST 2012 – AFTERNOON SESSIONS 14:45–16:15 | Algiers - Village 2 CLINICAL CONSIDERATIONS AND PRACTICAL APPROACHES TO MANAGING PATIENTS WITH DYSLIPIDEMIA Sponsored by MSD Satellite Symposium Chairperson(s): J.E. Deanfield (London, GB); J.J.P. Kastelein (Amsterdam, NL) 14:45 14:50 15:10 15:30 15:50 16:10 Chair welcome and opening remarks. – J.E. Deanfield (London, GB) Unmet medical need in the treatment of high-risk populations. – P.J. Barter (Sydney, AU) Effective treatment options with add-on or combination therapy. – C. Ballantyne (Houston, US) Comprehensive lipid management: a treatment paradigm for optimal cardiovascular risk reduction. – J.J.P. Kastelein (Amsterdam, NL) Panel discussion. – All Speakers Closing remarks. – J.E. Deanfield (London, GB), J.J.P. Kastelein (Amsterdam, NL) 4627 4628 4629 4630 4631 14:45–16:15 | Zagreb - Village 2 THE NEW ERA OF ORAL ANTICOAGULATION – ACHIEVEMENTS AND CHALLENGES Sponsored by Daiichi Sankyo Europe GmbH Satellite Symposium Chairperson(s): J. Weitz (Ontario, CA); A.J. Camm (London, GB) 14:45 14:50 15:05 15:20 15:35 15:50 16:10 Welcome and introduction. – J. Weitz (Ontario, CA) Novel oral anticoagulants in atrial fibrillation - A first inventory. – A.J. Camm (London, GB) Challenges of new oral anticoagulants in clinical practice. – H. Heidbuchel (Leuven, BE) The pharmacological basis of edoxaban development: once daily dosing. – R. De Caterina (Chieti, IT) ENGAGE AF-TIMI 48 - Edoxaban in atrial fibrillation. What can we expect? – R.P. Giugliano (Boston, US) Panel discussion. – All Speakers Closing. – A.J. Camm (London, GB) 4632 4633 4634 4635 4636 4637 14:45–16:15 | Athens - Village 3 MAKING SENSE OF THE DATA: WHY STILL USE GP IIB/IIIA INHIBITORS IN HIGH-RISK ACUTE CORONARY SYNDROME PERCUTANEOUS CORONARY INTERVENTION? Sponsored by Janssen and Eli Lilly and Company Satellite Symposium Chairperson(s): H. Schuehlen (Berlin, DE); L. Bolognese (Arezzo, IT) 14:50 15:10 15:30 15:50 16:10 Introduction. – H. Schuehlen (Berlin, DE) Recent trial data – Revealing the death of GP IIb/IIIa inhibitors? – S.D. Kristensen (Aarhus, DK) Recent registry data – Flying in the face of the evidence? – U. Zeymer (Ludwigshafen, DE) Decoding the data – Applying the evidence, not reacting. – H. Ince (Rostock, DE) Discussion. – All Speakers Closing remarks. – L. Bolognese (Arezzo, IT) 4638 4639 TUESDAY – AFTERNOON 14:45 4640 4641 4642 271 TUESDAY, 28 AUGUST 2012 – AFTERNOON SESSIONS 14:45–16:15 | Nicosia - Village 3 ASSESSING AND MANAGING ON-TREATMENT CARDIOVASCULAR RISK: WHEN KEY “QUANTITY” TARGETS ARE MET, IN WHICH PATIENTS DOES “QUALITY” MAKE THE DIFFERENCE? PITAVASTATIN – A NEW TREATMENT OPTION IN PATIENTS WITH HIGH CARDIOVASCULAR RISK Sponsored by Recordati S.p.A / Kowa Satellite Symposium Chairperson(s): K.K. Ray (London, GB); J. Chapman (Paris, FR) 14:45 14:50 15:00 15:25 15:55 16:10 Chair’s introduction. – K.K. Ray (London, GB) Persistent challenges in the management of dyslipidaemia. – J. Chapman (Paris, FR) Pitavastatin in high risk patients: adding “quality” to “quantity”. – T. Hiro (Ube, JP) Pitavastatin: a new tool to address persistent challenges. – J.R. Gonzalez Juanatey (Santiago de Compostela, ES), P. Marques da Silva (Lisbon, PT) Audience Q&A. – K.K. Ray (London, GB) Chairs wrap up and close. – J. Chapman (Paris, FR) 4643 4644 4645 4646 4647 4648 14:45–16:15 | Vienna - Village 4 THE STEPS OF STABLE ISCHEMIC HEART DISEASE PATIENT’S MANAGEMENT Sponsored by The Menarini Group Satellite Symposium Chairperson(s): C.W. Hamm (Bad Nauheim, DE); J.L. Lopez-Sendon (Madrid, ES) 14:45 14:50 15:15 15:40 16:05 Welcome & introduction. – C.W. Hamm (Bad Nauheim, DE) The 1st step; to identify the stable ischemic heart disease patient. – C. Daly (Dublin, IE) The 2nd step: to reach the hub of the stable ischemic heart disease. – J.L. Tamargo (Madrid, ES) The 3rd step: the succesful management for the identified ischemic patients. – P.A. Merlini (San Donato Milanese, IT) Conclusions & summary. – J.L. Lopez-Sendon (Madrid, ES) 4649 4650 4651 4652 4653 15:30–16:30 | Moderated Posters - Village 10 SECONDARY PREVENTION: FROM AWARENESS TO ACTION Moderated Posters Chairperson(s): L. Ryden (Stockholm, SE); H. Voeller (Rudersdorf, DE) Posters must be set up between 13:30 and 14:00, removed between 18:00 and 18:30 and be on display from 14:00 to 18:00. The following abstracts were chosen for their outstanding quality and will be discussed in a special area in the Poster hall during the Moderated Poster Session chaired by the two above-mentioned chairpersons between 15:30 and 16:30. 15:30 15:37 15:45 15:52 16:00 16:07 16:15 16:22 272 Prevalence, co-prevalence and awareness of cardiovascular risk factors - results from the population based Gutenberg Health Study. – J. Prochaska, S. Goebel, A. Schulz, R.B. Schnabel, N. Khuseyinova, S. Herkenhoff, C. Espinola-Klein, S. Blankenberg, T. Muenzel, P.S. Wild (Mainz and Hamburg, DE) Use of lipid lowering therapy in primary care across Europe: results from the European study on cardiovascular risk prevention in daily practice (eurika). – J.P.J. Halcox, F. Tubach, J.R. Banegas, C. Borghi, J. Dallongeville, G. De Backer, J. Perk, P.G. Steg, F. Rodriguez-Artalejo, E. Guallar (Cardiff, GB; Paris and Lille, FR; Madrid, ES; Bologna, IT; Ghent, BE; Kalmar, SE) Low levels of IgM antibodies against phosphorylcholine (anti-PC) increase the risk of ischemic cardiovascular events among European men at high risk of cardiovascular events. – B. Gigante, K. Leander, R. Strawbridge, B. Sennblad, F. Veglia, D. Baldassarre, E. Tremoli, S.E. Humphries, J. Frostegard, U. De Faire (Stockholm, SE; Milan, IT; London, GB) Fasting and postprandial triglycerides are independent cardiovascular risk markers in non-obese coronary artery disease patients with normal glucose tolerance. – C. Werner, S. Groenewold, M. Fritsch, A. Filmer, S. Graeber, M. Böhm, U. Laufs (Homburg, DE) The effect of plant stanol esters on blood flow in adults. – P. Simonen, H. Gylling, H. Lindholm, J. Konttinen, M.J. Nissinen, M. Hallikainen (Helsinki and Kuopio, FI) Reduced blood pressure and risk of future cardiovascular disease from structured care algorithm in primary care patients with persistent hypertension: a multicentre randomized controlled trial. – S. Stewart, M.J. Carrington, C.H. Swemmer, N.P. Kurstjens, G.J. Jennings (Melbourne and Sydney, AU) Successful weight loss following gastric sleeve surgery improves vascular function in obese individuals. – M.E. Iancu, C.A. Copaescu, C. Ginghina (Bucharest, RO) The ferrari corporate wellness program: a new concept of cardiovascular prevention in the companies. – F. Fernando, A. Biffi, A. Carluccio, M.T. Carluccio, A.F.G. Cicero, C. Borghi (Rome and Bologna, IT) P4654 P4655 P4656 P4657 P4658 P4659 P4660 P4661 TUESDAY, 28 AUGUST 2012 – AFTERNOON SESSIONS 15:30–16:30 | Moderated Posters - Village 10 CARDIAC MAGNETIC RESONANCE ACROSS THE SPECTRUM OF CARDIOMYOPATHY Moderated Posters Chairperson(s): A.C. Van Rossum (Amsterdam, NL); J. Schulz-Menger (Berlin, DE) Posters must be set up between 13:30 and 14:00, removed between 18:00 and 18:30 and be on display from 14:00 to 18:00. The following abstracts were chosen for their outstanding quality and will be discussed in a special area in the Poster hall during the Moderated Poster Session chaired by the two above-mentioned chairpersons between 15:30 and 16:30. 15:30 15:37 15:45 15:52 16:00 16:07 16:15 16:22 Comprehensive assessment of diastolic function from velocity-encoded cardiac magnetic resonance in patients with hypertrophic cardiomyopathy. – G. Ashrafpoor, N. Kachenoura, E. Bollache, L. Macron, A. Azarine, E. Bruguiere, M. Desnos, A. Hagege, E. Mousseaux, A. Redheuil (Paris, FR) High energy myocardial metabolism in patients with different causes of left ventricular hypertrophy by 31P magnetic resonance spectroscopy. – V.V. Mazaev, O.V. Stukalova, S.A. Gabrusenko, F.T. Ageev, S.K. Ternovoy, I.E. Chazova (Moscow, RU) The left atrium build-up of amyloid in patients with cardiac amyloidosis (CA) is associated with left atrium dysfunction: morphological and functional evaluation by cardiac magnetic resonance. – E. Di Pietro, E. Liodakis, A. Grasso, F. Secchi, A. Rapacciuolo, M.C. De Angelis, F. Esposito, G. Maresca, S. Bartolome Mateos, S. Prasad (Naples and Milan, IT; London, GB) Role of cardiovascular magnetic resonance in the diagnosis and management of constrictive pericarditis. – A. Cagnolo, A. Barison, G.D. Aquaro, C. Ardenghi, M. Carrozzo, M. Deiana, A. Balbarini, M. Lombardi (Pisa, IT) Late gadolinium enhanced cardiac magnetic resonance in lamin A/C, cardiac troponin T and myosin binding protein C gene mutation related cardiomyopathies: characteristics and clinical associations. – A. Santosa, J. Franke, D. Schmahl, B. Meder, R. Pribe, P. Ehlermann, G. Kopietz, H. Steen, G. Korosoglou, H.A. Katus (Heidelberg, DE) Diffuse myocardial fibrosis by post-contrast T1-time is closely related to the degree of heart failure in heart failure with normal ejection fraction. – B.A. Marzluf, D. Bonderman, S. Pfaffenberger, E. Ringelspacher, M. Huelsmann, C. Tufaro, I.M. Lang, G. Maurer, R. Pacher, J. Mascherbauer (Vienna, AT) Relation of myocardial fibrosis to left ventricular and mitochondrial function in nonischemic dilated cardiomyopathy -a comparison focal and interstitial fibrosis-. – T. Yamada, A. Hirashiki, X.W. Cheng, T. Okumura, S. Shimazu, R. Okamoto, N. Shinoda, K. Takeshita, T. Murohara (Nagoya, JP) Uniformity of circumferential strain and strain delay index are the most relevant left intraventricular dyssynchrony indices to identify patients with impaired left ventricular function. – S. El Ghannudi, E. Breton, M.Y. Jeung, P. Croisille, P. Germain (Strasbourg and Saint Etienne, FR) P4662 P4663 P4664 P4665 P4666 P4667 P4668 P4669 16:30–17:30 | Berlin - Village 2 2ND SATELLITE SYMPOSIUM ON RARE CARDIOVASCULAR DISEASES Satellite Symposium Sponsored by Centre for Rare Cardiovascular Diseases in John Paul II Hospital, Krakow, Poland Chairperson(s): P. Podolec (Krakow, PL); A. Torbicki (Otwock, PL); J.G.F. Cleland (Kingston-upon-Hull, GB) 16:32 Introduction. – P. Podolec (Krakow, PL) Rare diseases: a priority in public health and research. – S. Ayme (Paris, FR) 4670 4671 TUESDAY – AFTERNOON 16:30 Pregnancy in patient with Turner syndrome, coarctation of aorta, bicuspid aortic valve and aneurysm of aorta 16:47 16:56 17:01 Case presentation. – L. Tomkiewicz-Pajak (Krakow, PL) How would I treat? – P. Hoffman (Warsaw, PL) Comment. – Z. Gasior (Katowice, PL) 4672 4673 4674 Rapid clinical detoriation after first line treatment of a patients with idiopathic pulmonary arterial hypertension 17:04 17:13 17:18 17:21 17:24 Case presentation. – G. Kopec (Krakow, PL) How would I treat? – N. Galie (Bologna, IT) Comment. – P. Rubis (Krakow, PL) The journal of Rare Cardiovascular Diseases - First issue. – J. Podolec (Krakow, PL) The end of the symposium and closing remarks. – A. Torbicki (Otwock, PL), J.G.F. Cleland (Kingston-upon-Hull, GB) 4675 4676 4677 4678 4679 273 TUESDAY, 28 AUGUST 2012 – AFTERNOON SESSIONS 16:30–18:00 | Zagreb - Village 2 DUAL ANTIPLATELET THERAPY IN STEMI PATIENTS: FROM STATISTICAL SIGNIFICANCE TO CLINICAL RELEVANCE Sponsored by Daiichi Sankyo Europe GmbH & Eli Lilly and Company Satellite Symposium Chairperson(s): P.M. Clemmensen (Copenhagen, DK); G. Montalescot (Paris, FR) 16:30 16:35 17:00 17:25 17:50 Welcome and introduction. – G. Montalescot (Paris, FR) Current experience. – U. Zeymer (Ludwigshafen, DE) Current recommendations and corresponding data. – P. Widimsky (Prague, CZ) Future perspectives of treatments in STEMI patients. – P. Goldstein (Lille, FR) Discussion and concluding remarks. – P.M. Clemmensen (Copenhagen, DK) 4680 4681 4682 4683 4684 16:30–17:30 | Prague - Village 4 INNOVATION IN HYPERTENSION: MULTI-ELECTRODE RENAL NERVE ABLATION FOR THE TREATMENT OF HYPERTENSION Sponsored by St. Jude Medical Satellite Symposium Chairperson(s): M. Caulfield (London, GB); T.F. Luescher (Zurich, CH) 16:30 16:40 16:55 17:10 17:25 274 Opening: the burden of hypertension and the role of the sympathetic nervous system in modulating BP. – M. Caulfield (London, GB) Multi-electrode renal nerve ablation – Procedure walkthrough and initial clinical results. – C. Tsioufis (P.Penteli, Athens, GR) Resistant hypertension – Initial treatment and referrer observations. – C. Borghi (Bologna, IT) Patient selection – Characterizing the best responders for renal nerve ablation – Now and in the future. – M. Lobo (London, GB) Conclusion and take-away message. – T.F. Luescher (Zurich, CH) 4685 4686 4687 4688 4689 TUESDAY, 28 AUGUST 2012 – AFTERNOON POSTERS 14:00–18:00 | Posters - Village 10 POSTER SESSION 6 Poster Session ARRHYTHMIA MECHANISMS AND ANTIARRHYTHMIC DRUGS Ranolazine modifies the electrophysiological effects of acute myocardial stretching. – L. Brines Ferrando, L. Such-Miquel, I. Del-Canto, C. Soler, G. Parra, N. Gallego, J. Barber, A. Alberola, L. Such, F.J. Chorro (Valencia, ES) Novel electrophysiological properties of dronedarone: Inhibition of human cardiac two-pore-domain potassium (K2P) channels. – C. Schmidt, F. Wiedmann, P.A. Schweizer, R. Becker, H.A. Katus, D. Thomas (Heidelberg, DE) Mechanisms of antiarrhythmic activity of new class III agent Niferidile in patients with supraventricular arrhythmias. – N. Mironov, S.P. Golitsyn, S.F. Sokolov, E.B. Maikov, Y.U.A. Yuricheva, N.B. Shlevkov, L.V. Rosenstraukh, E.I. Chazov (Moscow, RU) Flecainide improves exercise testing parameters in patients with catecholaminergic polymorphic ventricular tachycardia. – E. Zorio Grima, D. Domingo Valero, M.A. Arnau Vives, J. Soriano Falco, P. Medina Badenes, J. Rueda Soriano, M.J. Sancho-Tello De Carranza, A. Salvador Sanz (Valencia, ES) Value-based pricing for dabigatran, rivaroxaban and apixaban in patients with non-valvular atrial fibrillation in Germany. – M. Krejczy, S. Marx, K. Obermann, M. Wehling, J. Harenberg (Mannheim, DE) Network meta-analysis of efficacy and safety of dabigatran, rivaroxaban and apixaban in patients with non-valvular atrial fibrillation. – S. Marx, H.-C. Diener, J. Harenberg, G. Lip, V. Marder, M. Wehling, C. Weiss (Mannheim and Essen, DE; Birmingham, GB; Los Angeles, US) Administration of vernakalant in a highly sensitive model of proarrhythmia caused prolongation of myocardial repolarization without increased vulnerability to arrhythmias. – S. Kaese, G. Frommeyer, C. Clauss, M. Schmidt, L. Eckardt, P. Milberg (Münster, DE) P4690 P4691 P4692 P4693 P4694 P4695 P4696 ARRHYTHMIA MECHANISMS P4697 P4698 P4699 P4700 P4701 P4702 TUESDAY – AFTERNOON F 16915 prevents heart failure induced atrial structural remodelling: a promising new drug as up-stream therapy for atrial fibrillation. – C. Pignier, R. Letienne, F. Lantoine-Adam, M. David-Dufilho, S. Hatem, B. Le Gand (Castres and Paris, FR) Zooming in on the focus: flecainide inhibits atrial fibrillation maintained by aconitine. – D. Linz, J. Eckstein, B. Maesen, A. Van Hunnick, S. Verheule, U. Schotten (Homburg, DE; Basel, CH; Maastricht, NL) Absence of cyclase-associated protein 2 leads to marked atrial and ventricular conduction delays and ventricular arrhythmias. – F. Stoeckigt, V. Peche, A.A. Noegel, G. Nickenig, M. Linhart, R. Andrie, J.W. Schrickel (Bonn and Cologne, DE) NRDc regulates circulatory dynamics through modulating sinus node automaticity and cardiac sympathetic innervation. – M. Ohno, Y. Hiraoka, T. Matsuoka, K. Nishi, S. Saijo, H. Matsuura, T. Kita, E. Nishi, T. Kimura (Kyoto, Otsu and Kobe, JP) Decreased connexin43/Nav1.5 expression and reduced sodium current through downregulation of desmoplakin by small RNA interference in HL-1 cardiomyocytes. – Q.H. Zhang, S.L. Wu, C.Y. Deng, F. Rao, J.N. Zhu, X.Y. Liu, L.P. Mai, H.H. Tan, D.Z. Xiao, X.Y. Yu (Guangzhou, CN) Validation of an increased Tpeak-Tend interval in a large series of Brugada syndrome patients as a highly and independently ECG parameter related to symptoms and cardiac events. – P. Maury, A. Rollin, V. Probst, F. Sacher, J.L. Pasquie, F. Raczka, J.B. Gouraud, A. Duparc, J.M. Davy, M. Haissaguerre (Toulouse, Nantes, Bordeaux and Montpellier, FR) Induction of torsades des pointes is facilitated by stimulation of extra-cardiac alpha-adrenergic receptors. – M.B. Thomsen, T. Mow (Copenhagen, DK) Ranolazine suppresses atrial fibrillation in an experimental model of chronic heart failure due to development of atrial postrepolarization refractoriness and slowing of conduction velocity. – P. Milberg, G. Frommeyer, S. Rajamani, L. Belardinelli, L. Eckardt (Münster, DE; Palo Alto, US) Myofibroblasts do not contribute to the substrate for atrial fibrillation. A study of human left atrial appendages. – S.P.J. Krul, S.C.M. Van Amersfoorth, G.S.C. Geuzenbroek, A.H.G. Driessen, A.A.M. Wilde, J.M.T. De Bakker, J.R. De Groot (Amsterdam, Nieuwegein and Utrecht, NL) Cervical vagal nerves contain sympathetic ganglion cells. – H.W.P. Park, P.S.S. Chen, M.C.F. Fishbein (Gwangju, KR; Indianapolis and Los Angeles, US) EUK-8, an antioxidant suppresses the electrical remodeling induced by hyperglycemia in heart/muscle-specific manganese superoxide dismutase-deficient mice. – S. Ishikawa, S. Niwano, H. Niwano, M. Murakami, A. Satoh, Y. Masaki, T. Kosukegawa, T. Shimizu, T. Izumi (Kanagawa and Chiba, JP) An in vitro model of early or late reperfusion-scars to explain clinical reentrant arrhythmia characteristics and anti-arrhythmic potential of pharmacologic or electric defibrillation. – S.F. Askar, S.R.D. Piers, K. Zeppenfeld, M.J. Schalij, D.A. Pijnappels (Leiden, NL) P4703 P4704 P4705 P4706 P4707 P4708 275 TUESDAY, 28 AUGUST 2012 – AFTERNOON POSTERS The anatomic relationship between the right and left ventricular outflow tracts: its relevance in catheter ablation. – J.A. Cabrera, M. Murillo, G. Pizarro, E. Gonzalez-Caballero, B. Fuertes, S. Bayona, A. Garcia-Lopez, A. Pastor, D. Sanchez-Quintana (Madrid and Badajoz, ES) Acute block of Kv1.5 channels by DHA increases rabbit atrial refractory period. – C. Pignier, R. Letienne, B. Le Grand (Castres, FR) The change of preferential internodal pathways during sympathetic stimulation. – H.S. Mun, J. Wee, J. Shim, J.S. Uhm, J.Y. Kim, H.N. Pak, M.H. Lee, B. Joung (Seoul, KR) Depletion of connexin45 and connexin30.2 deteriorates AV-nodal conduction in the murine heart. – J.W. Schrickel, M. Frank, R. Andrie, L. Lickfett, G. Nickenig, K. Willecke (Bonn, DE) Dexmedetomidine and clonidine inhibit ventricular tachyarrhythmias in a rabbit model of acquired long QT syndrome. – K. Tsutsui, T. Mikamo, A. Sugiura, K. Kanamori, N. Yamagishi, S. Yamagishi, H. Watanabe, T. Kunishima, N. Hayami, Y. Murakawa (Kanagawa, JP) Lymphocytic cell infiltration of myocardium is associated with the episode of ventricular fibrillation in patients with brugada syndrome. – M. Tanaka, K. Nakamura, D. Miura, K. Nakagawa, N. Nishii, S. Nagase, H. Morita, K. Kusano, C. Yutani, H. Ito (Okayama, JP) P4709 P4710 P4711 P4712 P4713 P4714 ELECTROCARDIOGRAM/NON INVASIVE STUDIES/SYNCOPE False tendons are possibly associated with genesis of J-waves: prospective study in young healthy men. – M. Nakagawa, K. Ezaki, H. Miyazaki, Y. Teshima, K. Yufu, N. Takahashi, T. Saikawa (Yufu, JP) Partial blockade of IK1 destabilizes the rotation center of spiral wave reentry without enhancement of wavefront-tail interactions in the arm. – Y. Kushiyama, H. Honjo, R. Niwa, H. Takanari, M. Yamazaki, Y. Takemoto, I. Sakuma, I. Kodama, K. Kamiya (Nagoya and Tokyo, JP) Effects of renal sympathetic denervation on heart rate and atrioventricular conduction in patients with resistant hypertension. – C. Ukena, F. Mahfoud, I. Kindermann, A. Spies, D. Linz, B. Cremers, U. Laufs, H.R. Neuberger, M. Böhm (Homburg, DE) Distribution of J waves on 87-lead body surface map in patients with inferolateral early repolarization syndrome. – T. Kobayashi, S. Kamakura, K. Miyamoto, Y. Yamada, H. Okamura, T. Noda, K. Satomi, T. Aiba, S. Yasuda, W. Shimizu (Suita, JP) QT peak prolongation predicts cardiac death following stroke. – K. Y.-K. Wong, R.S. Macwalter, D. Douglas, H. Fraser, A.D. Struthers (Hull and Dundee, GB) Changes in QRS duration in ECG leads with ST segment elevation differentiate acute pericarditis and acute transmural myocardial ischemia. – X. Rossello, R.F. Wiegerinck, J. Alguersuari, A. Bardaji, F. Worner, M. Sutil, A. Ferrero, J. Cinca (Barcelona, Palma de Mallorca, Tarragona and Lleida, ES) Is QRS axis pattern associated to the type of surgical repair in adults with operated tetralogy of fallot? – Z. Jalal, N. Combes, J.B. Thambo, M. Haissaguerre, F. Sacher (Bordeaux-Pessac and Toulouse, FR) Early repolarization patterns in young healthy individuals: prevalence, morphological characteristics and impact of gender, ethnicity and physical activity. – S. Ghani, S. Di Fino, A. Gravina, A. Zaidi, N. Sheikh, S. Gati, H. Raju, S. Sharma (London, GB) The prognostic value of sinoatrial block of Wenckebach type (Mobitz I) in patients with symptoms suggestive of paroxysmal cardiac arrhythmias. – E. Kramarz, K. Makowski (Warsaw, PL) Cardiac autonomic disturbances in patients with vasovagal syndrome: comparison between 123I-metaiodobenzylguanidine myocardial scintigraphy and heart rate variability. – G.E. Kochiadakis, M.E. Marketou, S. Koukouraki, F. Parthenakis, G.E. Chlouverakis, N. Karkavitsas, P.E. Vardas (Heraklion, GR) Screening for arrhythmogenic myocardial substrate by 12-lead ECG, high resolution ECG and T-wave alternans in patients with low to intermediate sudden cardiac death risk. – N. Mewton, D.G. Strauss, P. Rizzi, R.L. Verrier, L.G. Tereshchenko, B. Nearing, F.E. Marchlinski, C. Cox, P.M. Spooner, J.A.C. Lima (Bron, FR; Siver Spring, Baltimore, Boston and Philadelphia, US) Fragmented QRS complex in patients with Idiopathic Ventricular Fibrillation. – S.J. Park, K.M. Byeon, S.H. Lee, Y.K. On, J.S. Kim (Seoul, KR) Prevalence, electrocardiographic characteristics and variations of early repolarization syndrome on a population of healthy subjects. – P.H. Heno, A. Rossi, O. Manen, S. Bisconte, B. Azman, J. Louembe, J. Deroche, V. Kanczuga, E. Perrier (Clamart, FR) Various morphological ventricular premature beats with fragmented QRS waves on a 12 lead holter ECG had a positive relationship with the left ventricular fibrosis on CT in hypertrophic cardiomyopathy. – K. Ozawa, N. Funabashi, H. Takaoka, A. Kataoka, M. Uehara, Y. Kobayashi (Chiba, JP) Association of sudden cardiac death and ambient temperatures in scotland, 1995-2004. – A. Shah, C. Yap, S. Cobbe, A. Mcconnachi, D.E. Newby, N.L.M. Mills, J. Pell (Edinburgh, Birmingham and Glasgow, GB) Prediction of ventricular arrythmias by QRS-fragmentation detected with magnetic field imaging (MFI) among patients with reduced left ventricular ejection fraction. – T. Tonnis, A. Cuneo, K. Kyriazis, A. Ujeyl, K.H. Kuck (Hamburg, DE) 276 P4715 P4716 P4717 P4718 P4719 P4720 P4721 P4722 P4723 P4724 P4725 P4726 P4727 P4728 P4729 P4730 TUESDAY, 28 AUGUST 2012 – AFTERNOON POSTERS How to differentiate patients at risk of cardiac and non-cardiac death using heart rate and its variability? – J. Sacha, S. Barabach, G. Statkiewicz-Barabach, K. Sacha, A. Muller, J. Piskorski, G. Schmidt (Opole, Wroclaw, Krakow and Poznan, PL; Munich, DE) Treatment of patients with inappropriate sinus node tachycardia: If-channel inhibition or ablation? – J. Borbola, P. Abraham, C.S. Foldesi, A. Kardos (Budapest, HU) The role of non-invasive methods in determining the arrhythmic risk in myotonic dystrophy type 1. – C. Calore, A. Polo, V. Romeo, F. Folino, G. Buja, C. Angelini, E. Bonifazi, E. Pegoraro, S. Iliceto, P. Melacini (Padua and Rome, IT) Exploring the origin of J-wave with magnetocardiography (MCG): depolarization or repolarization? – N. Iwakami, S. Kamakura, H. Takaki, S. Hashimoto, H. Okamura, T. Noda, K. Satomi, T. Aiba, W. Shimizu, M. Sugimachi (Suita, JP) The importance of atrioventricular conduction and myocardial function in ventricular arrhythmogenesis in lamin A/C mutation carriers. – N.E. Hasselberg, T. Edvardsen, H. Petri, K.E. Berge, T.P. Leren, H. Bundgaard, K.H. Haugaa (Oslo, NO; Copenhagen, DK) Left atrial strain predicts postoperative atrial fibrillation in patients waiting for aortic valve replacement for aortic stenosis. – M. Cameli, M. Lisi, R. Reccia, E. Bigio, E. Bennati, A. Malandrino, M. Maccherini, M. Chiavarelli, M. Henein, S. Mondillo (Siena, IT; Umeå, SE) Clinical aspects and prognosis of type 1 ECG pattern of Brugada syndrome. – K. Letsas, M. Efremidis, P. Korantzopoulos, N. Fragakis, K. Kappos, P. Strempelas, G. Bakosis, C. Kavvouras, A. Sideris, T. Arentz (Athens, Ioannina and Thessaloniki, GR; Bad Krozingen, DE) T-wave alternans is helpful for predicting recurrence of fatal arrhythmias in ventricular fibrillation survivors. – S. Yamada, H. Suzuki, M. Sato, S. Iwaya, M. Kamioka, Y. Kamiyama, S. Saitoh, Y. Takeishi (Fukushima, JP) Utility of magnetocardiography for detection of delayed potentials, epsilon waves, with arrhythmogenic right ventricular cardiomyopathy. – Y. Ito, K. Yoshida, N. Murakoshi, H. Tada, Y. Sekiguchi, M. Igarashi, H. Yamasaki, K. Kuroki, T. Kaneshiro, K. Aonuma (Ibaraki, JP) P4731 P4732 P4733 P4734 P4735 P4736 P4737 P4738 P4739 SYNCOPE P4740 P4741 P4742 P4743 P4744 P4745 P4746 TUESDAY – AFTERNOON Home orthostatic training is not effective in elderly patients With vasovagal syncope - a prospective randomised controlled trial. – S. Podd, J. Hunt, A.N. Sulke (Eastbourne, GB) Additional diagnostic value of very prolonged observation by implantable loop recorder in patients with unexplained syncope. – R. Maggi, T. Furukawa, C. Bertolone, D. Fontana, M. Brignole (Lavagna, IT) Vasovagal syncope mediated by emotional distress associated with increased risk of cardiovascular events. – D. Zysko (Wroclaw, PL) Two-year diagnostic yield of implantable loop recorder in patients with neurally-mediated syncope enrolled in the ISSUE3 trial. – M. Tomaino, M. Brignole, V. Russo, R. Massa, C. Menozzi, M. Gulizia, T. Kus, M. Iorfida, H.H. Ebert, R. Sutton (Bolzano, Lavagna, Taranto, Alessandria, Reggio Emilia, Catania and Turin, IT; Montreal, CA; Riesa, DE; London, GB) Tilt table testing in patients with suspected epilepsy. – I. Rangel, J. Freitas, A. Sousa, A.S. Correia, A. Lebreiro, M. Paiva, C. Sousa, M.J. Maciel (Porto, PT) Incidence, etiology and predictors of adverse outcomes in 43315 patients presenting to the emergency department with syncope: an international meta-analysis. – F. D’Ascenzo, G. Biondi Zoccai, M.J. Reed, F. Gaita (Turin and Rome, IT; Edinburgh, GB) The risk of clotting induced by orthostatic stress patients with vaso-vagal syncope. – A.Z. Pietrucha, I. Bzukala, D. Fedak, M. Wnuk, E. Konduracka, W. Piwowarska, J. Nessler (Krakow, PL) Incidence of permanent atrioventricular block in patients with syncope and bifascicular block. – C. Ukena, F. Mahfoud, I. Lee, H.R. Neuberger, M. Böhm, A. Buob, G. Froehlig (Homburg, DE) Prevalence of depression syndrome in patients with vaso-vagal syncope. – A.Z. Pietrucha, A. Borowiec, D. Mroczek-Czernecka, M. Wnuk, I. Bzukala, M. Wegrzynowska, E. Konduracka, O. Kruszelnicka, W. Piwowarska, J. Nessler (Krakow, PL) The CHADS2 risk score predicts long-term outcome after first admission for syncope - A nationwide study. – M. Ruwald, C. Jons, M. Lock Hansen, A.C.H. Ruwald, M.V. Hojgaard, L. Kober, C. Torp-Pedersen, J. Hansen, G. Gislason (Hellerup and Copenhagen, DK) Pictureconomics: a micro-costing analysis of diagnostic investigations for unexplained syncope. – N. Edvardsson, S. Tsintzos, C. Garutti, G. Rieger, N. Linker (Gothenburg, SE; Maastricht, NL; Middlesbrough, GB) Remote monitoring of implantable loop recorders: high artefact in the early phase following implant. – I.A. Fazal, R. Bhardwaj, M. Tynan, C.J. Plummer, J.M. Mccomb (Newcastle-upon-Tyne, GB) In patients with vasovagal syncope the increase of adrenomedullin during the positive head-up tilt test correlates with HRV parameters. – J. Gajek, D. Zysko (Wroclaw, PL) The influence of the menstrual cycle on the tilt testing result. – D. Zysko, J. Gajek, L. Terpilowski, A.K. Agrawal, P. Wroblewski, J. Rudnicki (Wroclaw, PL) P4747 P4748 P4749 P4750 P4751 P4752 P4753 277 TUESDAY, 28 AUGUST 2012 – AFTERNOON POSTERS PERCUTANEOUS CORONARY INTERVENTION: INVASIVE IMAGING/DEVICES AND TECHNIQUE Head to head comparison of fully drug-free bioresorbable PLA and bare metal stents in normal porcine coronary: a six-month angiography and OCT follow-up study. – E. Durand, M. Vert, T. Sharkawi, A. Lafont (Paris and Montpellier, FR) The volume of lipid-rich plaque, measured by integrated backscatter IVUS was associated with amount of captured plaques by filter-type distal protection device during coronary intervention. – K. Kitagawa, T. Uetani, A. Kunimura, Y. Shimbo, H. Ando, K. Harada, T. Yoshida, T. Amano, T. Matsubara, T. Murohara (Nagoya and Nagakute-Cho, JP) Effects of the intravascular ultrasound-guided true lumen tracking for recanalization of chronic total occlusion. – H. Tanaka, K. Kadota, S. Habara, Y. Fuku, T. Goto, K. Mitsudo (Kurashiki, JP) Nine months optical coherence tomography evaluation of neointimal coverage of a strategy of paclitaxel-eluting balloon plus bare metal stent. – I. Porto, K. Ducci, G. Cautilli, P. Angioli, S. Grotti, G. Falsini, F. Liistro, L. Bolognese (Arezzo, IT) Intravascular ultrasound guided everolimus eluting stent implantation resolves the disadvantage of thin strut cobalt chromium platform in patients with diabetes. – H. Takahashi, S. Yamada, T. Hayashi, Y. Yasaka, S. Kobayashi, T. Takaya, N. Miyoshi, S. Oishi, T. Toba, M. Yokoyama (Himeji, JP) Feasibility and efficacy of ex-vivo stent fracture detection by optical coherence tomography (OCT) and microcomputed tomography (microCT). – M. Vorpahl, V. Veulemanns, P. Horn, T. Ball, D. Zlotnik, P. Maurovic-Horvat, T. Zeus, R. Westenfeld, M. Kelm, J. Foerst (Düsseldorf, DE; Roanoke and Lebanon, US; Budapest, HU) Neointimal appearance of late clinical event related lesions after bare-metal stent and sirolimus-eluting stent implantation assessed by Optical Coherence Tomography. – Y. Ino, T. Kubo, H. Kitabata, Y. Ozaki, Y. Shiono, T. Yamaguchi, T. Tanimoto, K. Hirata, T. Imanishi, T. Akasaka (Wakayama, JP) Assessment of coronary vascular response after first in man implantation of a novel thin strut low profile fixed wire stent. – R. Diletti, H.M. Garcia-Garcia, V. Farooq, P. Stella, P. Agostoni, J. De Schepper, M. Pomeranz, P.W. Serruys (Rotterdam and Utrecht, NL; New Providence, US) Development of microporous covered stents for treating cerebral aneurysms without disturbing branching vascular flow. – Y. Nakayama, S. Nishi, H. Ishibashi-Ueda, M. Miyake, A. Wada (Osaka, Sapporo, Suita and Okayama, JP) Sex-related differences in percutaneous coronary interventions for chronic total occlusions. – G. Ferrante, P. Garot, T. Harb, T. Unterseeh, H. Benamer, M.C. Morice, T. Lefevre, Y. Louvard (Massy and Quincy, FR) Impact of final kissing balloon in distal left main bifurcation lesions treated with single or two stents techniques. – S.W. Rha, B.G. Choi, A. Elnagar, S.I. Im, S.W. Kim, S.W. Han, C.U. Choi, C.G. Park, H.S. Seo, D.J. Oh (Seoul, KR) Very late stent thrombosis in diabetic patients on long-term dual antiplatelet treatment after 1st generation drug-eluting stent implantation: comparison with patients on single antiplatelet treatment. – V. Voudris, P. Karyofyllis, C. Doulaptsis, I. Moukas, S. Thomopoulou, D.V. Cokkinos (Athens, GR) Predilatation with drug eluting balloon followed by bare metal stent implantation versus drug eluting stent in the treatment of simple de-novo native coronary stenosis. – F. Liistro, I. Porto, P. Angioli, S. Grotti, K. Ducci, G. Falsini, L. Bolognese (Arezzo, IT) Differential determinants of early stent thrombosis in drug-eluting and bare metal stents: ex vivo human autopsy study. – M. Nakano, F. Otsuka, S.K. Yazdani, A.V. Finn, R. Kutys, E.R. Ladich, F.D. Kolodgie, R. Virmani (Gaithersburg and Atlanta, US) Angiographic and clinical outcome in the treatment of restenosis of drug eluting stents with drug coated balloons in diabetics: insights from the PEPCAD-DES: study. – H. Rittger, A.M. Sinha, J. Brachmann, W.G. Daniel, J. Woehrle (Erlangen, Hof, Coburg and Ulm, DE) Angiographic and clinical outcomes of paclitaxel coated balloon angioplasty versus uncoated balloon angioplasty in drug eluting stent resenosis: insights from the PEPCAD-DES study. – H. Rittger, A.M. Sinha, M. Waliszewski, J. Brachmann, W.G. Daniel, J. Woehrle (Erlangen, Hof, Melsungen, Coburg and Ulm, DE) Thin-strut stent is favorable for severe calcified lesion needed rotational atherectomy in real world Percutaneous Coronary Intervention. – Y. Lee, M. Nishino, M. Taniike, N. Makino, H. Kato, Y. Egami, R. Shutta, J. Tanouchi, Y. Yamada (Osaka, JP) Angiographic outcomes of everolimus-eluting stent as compared to sirolimus-eluting stent: a sub-study of the RESET trial. – K. Kozuma, N. Suzuki, K. Tanabe, S. Suwa, M. Iwabuchi, K. Igarashi, Y. Morino, K. Kimura, K. Kadota, T. Kimura (Tokyo, Shizuoka, Kitakyushu, Sapporo, Morioka, Yokohama, Kurashiki and Kyoto, JP) Stent maximal expansion capacity with current DES platforms: a critical factor for left main stent selection? – N. Foin, S. Sen, C. Di Mario, J.E. Davies (London, GB) Is there an advantage in using second vs. first generation drug eluting stents in acute coronary syndromes? – C. Machado, L. Raposo, H. Dores, S. Leal, P. Goncalves, R. Teles, H. Mesquita Gabriel, M. Almeida, M. Mendes (Ponta Delgada and Lisbon, PT) 278 P4754 P4755 P4756 (W) P4757 P4758 P4759 P4760 P4761 P4762 P4763 P4764 P4765 P4766 P4767 P4768 (W) P4769 (W) P4770 P4771 P4772 P4773 TUESDAY, 28 AUGUST 2012 – AFTERNOON POSTERS The anti-proliferative effect of atorvastatin is dependent on stent surface material. – A. Strohbach, R. Begunk, H. Meyer Zu Schwabedissen, S.A. Walz, M.C. Busch, S.B. Felix, R. Busch (Greifswald, DE) One-year outcome after PCI for distal left main stenosis treated with single stenting or with T-stenting. – M. Ferenc, H.J. Buettner, M. Gick, T. Comberg, J. Rothe, C.H. Valina, R.-P. Kienzle, N. Loeffelhardt, H.-P. Bestehorn, F.-J. Neumann (Bad Krozingen, DE) Drug eluting stents with microporous polymeric covering as a scaffold for acquisition of extremely thin noeintimal lying without disturbing branching vascular flow. – Y. Nakayama, S. Nishi, H. Ishibashi-Ueda (Osaka and Sapporo, JP) Comparison of 3-year clinical outcomes between classic crush and modified mini-crush technique in coronary bifurcation lesions. – H.M. Yang, S.J. Tahk, S.Y. Choi, H.S. Lim, M.H. Yoon, B.J. Choi, K.W. Seo, J.W. Kim, G.S. Hwang, X. Jie (Suwon, KR) Assessment of an asymmetrical coating stent with sirolimus released from ablumial matrix in porcine model. – L. Shen, Y. Wu, F. Zhang, A. Sun, J. Qian, W. Zhong, J. Ge (Shanghai, CN) The ulnar puncture technique: lessons from experience. – R.M. Valdesuso Aguilar, J.R. Gimeno, F.J. Lacunza, J. Garcia De Lara, J. Hurtado, E. Pinar, M. Valdes (Murcia, ES) P4774 P4775 P4776 P4777 P4778 P4779 PERCUTANEOUS CORONARY INTERVENTION OUTCOMES P4780 P4781 P4782 P4783 P4784 P4785 P4786 P4787 TUESDAY – AFTERNOON The impact of circadian variations on long-term clinical outcomes in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. – J.B. Choi, K.S. Cha, M.J. Park, E.Y. Yun, H.W. Lee, J.H. Oh, J.H. Choi, H.C. Lee, T.J. Hong, S.G. An (Busan, KR) Impact of microalbuminuria on clinical cardiovascular outcomes in patients with mild renal dysfunction who underwent elective PCI. – A. Kunimura, T. Uetani, K. Kitagawa, Y. Shimbo, H. Ando, K. Harada, T. Yoshida, T. Matsubara, T. Amano, T. Murohara (Nagoya, JP) High preprocedural total adiponectin levels are associated with poor long-term cardiovascular outcome after percutaneous coronary intervention. – N. Kpogbemabou, D.C. Delhaye, S.A. Sudre, L.G. Lemesle, M.T. Modine, M.M. Mahmoudi, S.B. Steals, L.G. Luc, B.C. Bauters, L.J.M. Lablanche (Lille, FR; Cambridge, GB) Prognostic significance of body mass index for in-hospital and long-term mortality in patients undergoing primary percutaneous coronary intervention. – C.Y. Karabay, V. Oduncu, A. Kalayci, A. Guler, S.M. Aung, R. Zehir, A. Erkol, C. Gecmen, A. Kilicgedik, C. Kirma (Istanbul, TR) Comparison on 1-Year MACE of everolimus-eluting stent Xience vs sirolimus-eluting stent cypher in diabetic patients. – F. Liistro, I. Porto, S. Grotti, P. Angioli, K. Ducci, R. Brandini, G. Falsini, L. Bolognese (Arezzo, IT) Effects of EPC capture stent and CD34+ mobilization in acute myocardial infarction. – P. Scacciatella, M. D’Amico, M. Pennone, F. Conrotto, T. Usmiani, E. Meliga, I. Meynet, E. Pelloni, G. Amato, S. Marra (Turin, IT) Developments in the last ten years - LHC and PCI German registry results of the years 2010 compared to the year 2000. – B. Levenson, A. Albrecht, S. Goehring, W. Haerer, N. Reifart, G. Ringwald, B. Troger (Berlin, Ulm, Bad Soden, Bruchsal and Frankfurt am Main, DE) Multivessel versus culprit lesion percutaneous coronary intervention in ST-elevation myocardial infarction: is more worse? – D. Radovanovic, B. Nallamothu, O. Bertel, F. Eberli, G. Pedrazzini, S. Windecker, R. Jeger, P. Erne (Zurich, Lugano, Berne, Basel and Lucerne, CH; Michigan, US) Impact of successful thrombus retrieval during primary percutaneous coronary intervention with thrombus aspiration on the infarct size and microvascular obstruction: a magnetic resonance imaging study. – R. Chopard, P. Plastaras, J. Jehl, V. Descotes-Genon, M.F. Seronde, S. Janin, B. Kastler, F. Schiele, N. Meneveau (Besançon, FR) Real-world use of the second-generation cobalt-chromium sirolimus-eluting stents: 12-month results from the prospective multicentre FOCUS registry. – F. Zhang, J. Ge, J. Qian, L. Ge, J. Zhou (Shanghai, CN) Intra-procedural stent thrombosis: a new risk factor for adverse outcome in patients undergoing percutaneous coronary intervention for acute coronary syndrome. – S.J. Brener, A.J. Kirtane, M.B. Mcentegart, E. Cristea, K. Xu, R. Mehran, G.W. Stone (New York, US) Polymer-Free Sirolimus- versus Polymer-Based Paclitaxel-eluting stents. An individual patient data analysis of randomized trials. – S. Cassese, S. Desch, T. Tada, R.A. Byrne, L. King, J. Mehilli, A. Schomig, H. Thiele, A. Kastrati (Munich and Leipzig, DE) Lack of gender difference and improved in-hospital mortality rates in patients with cardiogenic shock following primary percutaneous coronary intervention: a UK tertiary cardiac centre registry study. – V. Kunadian, M. Veerasamy, A. Zaman (Newcastle-upon-Tyne, GB) In hospital clinical outcome of patients with definite stent thrombosis. – M. Almalla, J. Schroeder, N. Marx, R. Hoffmann (Aachen, DE) P4788 P4789 P4790 P4791 P4792 P4793 279 TUESDAY, 28 AUGUST 2012 – AFTERNOON POSTERS Twelve-month safety and performance results of the paclitaxel-eluting bioabsorbable magnesium scaffold in the prospective, multicenter first-in-man trial -BIOSOLVE-I. – M. Haude, R. Erbel, S. Verheye, R. Waksman, H. Degen, D. Boese, P. Vermeersch, P. Erne, J. Koolen (Neuss and Essen, DE; Antwerp, BE; Washington, US; Lucerne, CH; Eindhoven, NL) Cost-effectiveness of drug-coated balloon angioplasty and drug-eluting stent implantation for treatment of coronary in-stent restenosis. – M. Dorenkamp, A. Leber, C. Sohns, L. Boldt, M. Roser, F. Kleber, W. Haverkamp, K. Bonaventura (Berlin, Munich, Göttingen and Potsdam, DE) Difference of vascular response between everolimus- and paclitaxel-eluting stents for small coronary artery diseases: optical coherence tomography analysis. – K. Nasu, Y. Oikawa, S. Shirai, H. Hozawa, S. Tohara, M. Kadotani, H. Abe, Y. Takeda, S. Usui, T. Serikawa (Toyohashi, Tokyo, Kitakyushu, Adachi-ku, Kasukabe, Kakogawa, Matsumoto, Osaka and Fukuoka, JP) Pre-procedural serum albumin and C-reactive protein levels predict clinical outcome after Drug-Eluting Stents implantation in hemodialysis patients. – T. Aoyama, H. Ishii, H. Takahashi, Y. Kumada, D. Kamoi, Y. Kawamura, K. Kawashima, T. Sakakibara, M. Tanaka, T. Murohara (Nagoya, JP) Second vs. first generation DES are associated with a better safety profile in real world coronary percutaneous intervention: analysis of 3266 procedures from a single centre prospective registry. – H. Dores, L. Raposo, S. Leal, C. Machado, P.A. Goncalves, R.C. Teles, H.M. Gabriel, M.S. Almeida, M. Mendes (Lisbon, PT) Impact of adjunctive post-dilatation after drug-eluting stent implantation on the clinical outcomes in patients with acute myocardial infarction: Sub-study of EVER-ZOTA multicenter trial. – S.Y. Yoo, J.K. Sung, S.H. Lee, C.K. Lee, B.K. Lee, D.H. Yoon (Gangneung, Wonju and Chuncheon, KR) Bare-nitinol stent versus paclitaxel-coated balloon for femoro-popliteal revascularization. An adjusted indirect comparison meta-analysis of randomized trials. – S. Cassese, R.A. Byrne, I. Ott, T. Ibrahim, T. Tada, L. King, A. Kastrati, M. Fusaro (Munich, DE) P4794 P4795 P4796 P4797 (W) P4798 P4799 P4800 MANAGEMENT OF CORONARY ARTERY DISEASE AND PERCUTANEOUS CORONARY INTERVENTION COMPLICATIONS Bivalirudin Vs Unfractionated Heparin during Percutaneous Coronary Intervention in High Risk Patients for Bleeding. AntiCoagulant Regimen In high risk PAtients for Bleeding - ACRIPAB Trial. – A. Feldman, K. Suleiman, L. Bushari, E. Rozner, N.A. Freedberg, Y. Turgeman (Afula, IL) Triple over Dual anti-Platelet therapy was not mandatory in Acute Coronary Syndrome Patients with 2nd Generation Drug eluting Stent Implantation. – Y.-S. Choi, J.-Y. Kim, J.-S. Yu, W.-B. Chung, C.-S. Park, P.-J. Kim, K. Chang, H.-Y. Kim, W.-S. Chung, K.-B. Seung (Seoul, KR) Brain natriuretic peptide during coronary intervention prevents endothelial dysfunction post PCI via NP-cGMP activation. – A. Peleg, D. Ghanim, D. Qarawani, Y. Hasin (Tiberias, IL) Why is the posterior myocardial infarction the most frequent cause of acute mechanical complications? – S. Simek, J. Horak, T. Kovarnik, J. Belohlavek, M. Aschermann, V. Mrazek, J. Humhal, A. Linhart (Prague, CZ) Effect of high dose statin pretreatment on endothelial progenitor cells after percutaneous coronary intervention (Hipocrates study). – A. Eisen, D. Leshem-Lev, K. Orvin, T. Ben Gal, O. Daddush, A. Battler, E.I. Lev (Petah Tikva, IL) Elective percutaneous coronary intervention does not improve outcomes in patients with coronary artery disease (a prospective cohort study). – T.A. Ilyushchenko, A. Komarov, I. Levitskiy, A. Samko, O. Shakmatova, A. Deev, Y.U. Karpov, E. Panchenko (Moscow, RU) Onset-to-needle times in patients with ST-segment elevation myocardial infarction: shortest referral route to a primary coronary intervention facility. – H. Leleu, F. Capuano, M. Ferrua, G. Nitenberg, E. Minvielle, F. Schiele (Villejuif and Besançon, FR) Improved prognosis of weekends/holidays admission for acute myocardial infarction and a decreasing weekend-effect from 2005 to 2010. – J.H. Lee, S.Y. Jang, J.K. Kang, D.H. Yang, H.S. Park, Y. Cho, S.C. Chae, J.E. Jun, M.H. Jeong, Y.J. Kim (Daegu and Gwangju, KR) Syntax score predicts major bleeding after drug-eluting stent implantation. – R. Iijima, N. Nagashima, K. Yamazaki, T. Araki, M. Utsunomiya, M. Hori, H. Itaya, M. Shiba, H. Hara, M. Nakamura (Tokyo, JP) Clinical risk scores for the prediction of CIN before primary PCI. – G. Ando, G. Morabito, O. Trio, F. Saporito, C. De Gregorio, G. Oreto (Messina, IT) Comparison of the new Mayo Clinic risk scores and clinical SYNTAX Score in predicting adverse cardiovascular outcomes following percutaneous coronary intervention at our heart center. – H.J. Brown, J. Ho Khe Sui, C. Tan (Quezon City, PH) Protamine usage following implantation drug-eluting stents: is it safe? – B. Kremer Diniz Goncalves, A.L.T. Tedeschi, M.A.S. Sena, R.T.S.P. Peixoto (Niterói, BR) Does over-aggressive stent expansion without IVUS guidance predispose to restenosis? – Y. Chacko, K. Haladyn, R. Chan, R. Lim (Brisbane, AU) Impact of Mehran Risk Score for the prediction of Contrast-Induced Nephropathy in the Japanese patients who undergoing Percutaneous Coronary Intervention. – E. Ojima, A. Sato, T. Hoshi, H. Watabe, Y. Kakefuda, D. Abe, M. Endo, K. Aonuma (Moriya, Tsukuba, Hitachi and Kasama, JP) 280 P4801 P4802 P4803 P4804 P4805 P4806 P4807 P4808 P4809 P4810 P4811 P4812 P4813 P4814 TUESDAY, 28 AUGUST 2012 – AFTERNOON POSTERS Use of protamine fo rearly femoral sheath removal after coronary stent angioplasty. – B. Kremer Diniz Goncalves, A.L.T. Tedeschi, M.A.S. Sena, R.T.S.P. Peixoto, E.C.S.P. Peixoto (Niterói, BR) Comparison of additional versus no additional heparin during therapeutic oral anticoagulation in patients undergoing Percutaneous Coronary Intervention. – M.J. Pietila, P.P. Karjalainen, T.O. Kiviniemi, A. Ylitalo, M. Niemela, S. Vikman, M. Puurunen, F. Biancari, K.E.J. Airaksinen (Turku, Pori, Oulu, Tampere and Helsinki, FI) Functional syntax score improves stratification of risk in patients with left main coronary artery disease. – Y. Ntarladimas, M. Hamilos, L. Di Serafino, B. De Bruyne, E. Barbato (Aalst, BE) P4815 P4816 P4817 IMAGING OF THE RIGHT VENTRICLE P4818 P4819 P4820 P4821 P4822 P4823 P4824 P4825 P4826 P4827 P4828 P4829 P4830 P4831 TUESDAY – AFTERNOON Impact of real time 3D-echocardiography in the assessment of right ventricular volumes and function in patients with pulmonary hypertension. – I. Fabiani, L.C. Conte, C. Giannini, V. Barletta, L.A. Leo, P.L. Paggiaro, A. Palla, A. Balbarini, M. Marzilli, V. Di Bello (Pisa, IT) RV diastolic strain rate changes with age. – J. Willis, D.X. Augustine, R. Shah, J. Easaw (Bath and Oxford, GB; Penang, MY) Right ventricular dP/dt in normal subjects: feasibility and normal values. – E. Spitzer, J. Moreno Uzcategui, N. Campos Jordan, M. Quezada Feijoo, E. Lopez Soberon, L. Dominguez Perez, J. Guinea Esquerdo, G. Fuertes Ferre, L. Perez De Isla, C. Macaya (Madrid, ES) Pulmonary artery stiffness and right ventricular function in children at risk for obesity. – E. Farag, R. Mahfouz, T. Mostafa, I. Hosien (Zagazig, EG) Non-invasive assessment of right ventricular preload by Doppler echocardiography. – L. Halmai, T. Farkas, L. Rudas (Szeged, HU) Impact of untreated obstructive sleep apnea on left and right ventricular myocardial function and effects of CPAP therapy. – R. Schueler, M. Wiesen, D. Momcilovic, S. Pabst, G. Nickenig, D. Skowasch, C.H. Hammerstingl (Bonn, DE) Biomarkers and imaging in early diagnosis of right ventricular dysfunction. – O. Vittos, B. Toana, A. Vittos, F. Halici, E. Moldoveanu (Bucharest, RO) Echo derived tricuspid dP/dt as a marker of right ventricular function. – Y. Singbal, L.T. Huynh, W. Vollbon, S. Ngai, W. Wang, A. Ng, S. Wahi (Brisbane, AU) Tricuspid annular plane systolic excursion obtained in the right ventricular modified apical four chamber view shows strong correlation with right ventricular fractional area change. – S. Ugawa, H. Oe, N. Toh, Y. Kijima, R. Takemoto, N. Watanabe, Y. Tanabe, S. Sano, H. Ito (Okayama, JP) Right ventricular systolic function is highly dependent on left ventricular dysfunction in patients with previous myocardial infarction and high plasma brain natriuretic peptide levels. – K. Konishi, K. Dohi, Y. Sato, E. Sugiura, T. Sawai, H. Nakajima, S. Nakamori, K. Onishi, M. Nakamura, M. Ito (Tsu, JP) Clinical and echocardiographic predictors of right ventricular functional changes after acute myocardial infarction. – E. Abate, G.E. Hoogslag, M.L. Antoni, G. Nucifora, E.R. Holman, M.J. Schalij, J.J. Bax, V. Delgado, N. Ajmone Marsan (Leiden, NL) Comparison of strain measurements with speckle tracking echocardiography and velocity vector imaging in detection of RV dysfunction in patients with ischemic cardiomyopathy: a validation study with Ca. – J.H. Park, D.H. Kwon, T.H. Marwick (Cleveland, US) Right ventricular regional systolic function and dyssynchrony in patients with pulmonary hypertension evaluated by three-dimensional echocardiography. – D.H. Kong, X.H. Shu, C.Z. Pan, L.L. Cheng, D.X. Zhou, J.B. Ge (Shanghai, CN) Evolution of classic parameters and deformation of right ventricular function 1 year after cardiac transplant. – E. Gonzalez Lopez, V. Monivas Palomero, S. Mingo Santos, P. Beltran Correas, M. Sanchez Garcia, I. Garcia Lunar, M.A. Cavero Gibanel, J. Segovia Cubero, M. Gomez Bueno, L.A. Alonso Pulpon (Madrid, ES) AORTA AND AORTIC VALVE A new morphological and quantitative approach of aortic atheroma: a preliminary 3D transesophageal echocardiography study. – N. Hammoudi, M. Ihaddaden, L. Boubrit, C. Meuleman, S. Ederhy, P.L. Michel, S. Alamowitch, A. Cohen (Paris and Boulogne-Billancourt, FR) Assessment of the valvuloarterial impedance calculated with the use of 3-dimensional transesophageal echocardiography. – T. Saitoh, J. Tanaka, A. Furugen, K. Harada, S. Gurudevan, K. Tolstrup, R. Siegel, T. Shiota (Los Angeles, US) Transtoracic echocardiography to study the ascending aorta: in search of the best approach. – J.F. Rodriguez Palomares, G.T. Gisela Teixido, A.L. Ana Laynez, L.G. Laura Gutierrez, T.G. Teresa Gonzalez-Alujas, S.M. Sergi Moral, A.C. Amelia Carro, A.E. Arturo Evangelista, D.G. David Garcia-Dorado (Barcelona, ES) Incremental accuracy of transoesophageal echocardiography over transthoracic approach for description of functional anatomy of aortic regurgitation. – I. Mendez Santos, A. Castro, O. Araji, J.M. Barquero, L. Gonzalez Torres, R. Gomez Dominguez, B. Munoz Calero, J.M. Cruz Fernandez, P. Gallego Garcia De Vinuesa (Seville, ES) P4832 P4833 P4834 P4835 281 TUESDAY, 28 AUGUST 2012 – AFTERNOON POSTERS Gender difference in regression of myocardial hypertrophy after aortic valve replacement. – E. Maruyama, K.H. Hirata, T. Yamano, K. Ishibashi, T. Tanimoto, Y. Ino, T. Yamaguchi, T. Kubo, T. Imanishi, T. Akasaka (Wakayama, JP) Age-related increase in aortic stiffness affects longitudinal myocardial function and ventricular-arterial coupling in both systolic and diastolic phase in normal subjects. – C. Palombo, M. Kozakova, C. Morizzo, A.G. Fraser (Pisa, IT; Cardiff, GB) Significant recovery of left ventricular systolic function after transcatheter aortic valve implantation (TAVI) in aortic stenosis measured by longitudinal 2D strain echo after 1 year. – G. Baldenhofer, S. Spethmann, H. Dreger, M. Laule, V. Stangl, G. Baumann, K. Stangl, F. Knebel (Berlin, DE) Relationship between three-dimensional speckle-tracking echocardiography-derived left ventricular rotation and twist and aortic stiffness. – A. Nemes, A. Kalapos, P. Domsik, C. Lengyel, A. Orosz, T. Forster (Szeged, HU) A novel visualization of aortic arch stiffness using pulse wave tissue doppler imaging: correlation with complicated aortic plaque. – K. Kaneko, T. Takahashi, H. Saitou, N. Kiribayashi, K. Omi, T. Sasaki, T. Niizeki, S. Sugawara, I. Kubota (Sakata and Yamagata, JP) High-resolution vascular ultrasound imaging for accurate measurement of carotid intima-media thickness. – H. Taki, T. Sakamoto, K. Taki, M. Yamakawa, T. Shiina, M. Kudo, T. Sato (Kyoto and Otsu, JP) Real-time evaluation of the local carotid pulse wave velocity using ultrafast echo imaging in healthy population. – M. Pernot, M. Couade, M. Frank, T. Mirault, A. Blanchard, R. Niarra, M. Azizi, J. Emmerich, M. Tanter, E. Messas (Paris and Aix-en-Provence, FR) P4836 P4837 P4838 P4839 P4840 P4841 P4842 ATRIAL FIBRILLATION AND ATRIAL FUNCTION The relation between the CHADS2, CHA2DS2-VASc score and echocardiographic parameters of thromboembolism in patients with atrial fibrillation. – M.N. Kim, D.H. Cho, S.A. Kim, Y.H. Kim, J.I. Choi, S.M. Park, S.W. Park, Y.H. Kim, W.J. Shim (Seoul and Ansan-Si, KR) Assessment of left atrial deformation and dyssynchrony by three-dimensional speckle tracking imaging: comparative studies in healthy subjects and patients with atrial fibrillation. – A. Mochizuki, S. Yuda, Y. Oi, M. Kawamukai, J. Nishida, A. Muranaka, S. Shimoshige, K. Tsuchihashi, N. Watanabe, T. Miura (Sapporo, JP) Left atrial dyssynchrony in patients with paroxysmal atrial fibrillation - three-dimensional speckle tracking analysis. – A. Furukawa, H. Hoshiba, C. Miyasaka, H. Sato, T. Nagai, E. Tada, K. Kataoka, Y. Seino, K. Ishii (Osaka, JP) Measurement of left and right atrial volume in patients undergoing ablation for atrial arrhythmias: comparison of different algorithms of real-time 3D echocardiography. – H. Mueller, S. Reverdin, H. Burri, D. Shah, R. Lerch (Geneva, CH) Echocardiographic assessments of left atrial function in patients with chronic primary mitral regurgitation by two-dimensional speckle tracking. – Y. Ohara, Y. Fukuoka, I. Tabuchi, S. Sahara, S. Hosogi, M. Nishimoto, K. Yamamoto (Kochi, JP) Reference values of right atrial area and volume in healthy adults by two-dimensional echocardiography. – P. Henn, E. Gruenig, A. D’Andrea, M. Claussen, C. Nagel, N. Ehlken, F. Maier, F. Prange, E. Bossone, C. Fischer (Heidelberg and Grosshansdorf, DE; Naples and Salerno, IT) Reduced atrial reservoir function in fabry disease using Doppler strain imaging. – A. Boyd, D. Sillence, K. Devine, M. Tchan, N. Sadick, L. Thomas (Sydney, AU) Evaluation of left atrial appendage dysfunction by strain imaging using transthoracic echocardiography. – Y. Lee, M. Nishino, M. Taniike, N. Makino, H. Kato, Y. Egami, R. Shutta, J. Tanouchi, Y. Yamada (Osaka, JP) Comparison between two-dimensional and real-time three-dimensional speckle tracking echocardiography in the assessment of left atrial structure and function. – Y. Goto, R. Tanaka, K. Ono, T. Watanabe, R. Matsuoka, N. Onishi, T. Noda, S. Watanabe, M. Kasawaki, S. Minatoguchi (Gifu, JP) Prolonged atrial electromechanical conduction in hypertrophic cardiomyopathy and cardiac amyloidosis. – C. Iio, K. Inoue, K. Nishimura, A. Fujii, T. Nagai, J. Suzuki, A. Ogimoto, J. Higaki (Toon, JP) Left atrium deformation and cardiac resynchronization therapy. – N. Moreira, F. Soares, R. Teixeira, R. Martins, L. Elvas, N. Ribeiro, M.J. Ferreira, L.A. Providencia (Coimbra, PT) The role of 3D echo in accurate measurement of the left atrial appendage size. – S.Z. Zielke, H. Clausen, J. Newton (Oxford and London, GB) Evaluation of right atrial dysfunction using 3D echocardiography in patients with pulmonary artery hypertension. – K. Sakata, K. Sato, K. Takemoto, T. Minamishima, Y. Uesugi, J. Sueoka, K. Matsushita, M. Kataoka, T. Sato, H. Yoshino (Tokyo, JP) Supranormal diastolic function in elite endurance-athletes is related to left atrial geometry and function. – M. Florescu, O.A. Enescu, D. Mihalcea, R. Mincu, R.C. Rimbas, L.S. Magda, M. Cinteza, D. Vinereanu (Bucharest, RO) Dependence of atrial strain and strain rate on ventricular function - implications for the assessment of left atrial function. – A.D. Margulescu, E. Rees, R.M. Hocking, D.A. Rees, A.G. Fraser, D. Vinereanu (Bucharest, RO; Cardiff, GB) 282 P4843 P4844 P4845 P4846 P4847 P4848 P4849 P4850 P4851 P4852 P4853 P4854 P4855 P4856 P4857 TUESDAY, 28 AUGUST 2012 – AFTERNOON POSTERS NEW ULTRASOUND TECHNOLOGY Detection of pulmonary congestion using the newly-developed pocket-sized transthoracic echocardiographic imaging device in patients with suspected heart failure. – H. Oe, R. Takemoto, N. Toh, S. Ugawa, N. Watanabe, Y. Tanabe, S. Nagase, S. Sano, H. Ito (Okayama, JP) Test accuracy of hand-held echocardiographic imaging. – C. Prinz, J. Dohrmann, F. Van Buuren, T. Bitter, N. Bogunovic, D. Horstkotte, L. Faber (Bad Oeynhausen, DE) Effect of through plane motion for the accuracy of two-dimensional circumferential strain analysis. – M. Takeuchi, K. Otani, M. Iwataki, H. Kuwaki, K. Kaku, N. Haruki, H. Yoshitani, Y. Otsuji (Kitakyushu, JP) Diagnostic accuracy and cost-effectiveness of pocket-sized transthoracic echocardiography. – R. Kitada, S. Fukuda, H. Watanabe, H. Oe, Y. Abe, K. Shimada, M. Yoshiyama, H. Ito, J. Yoshikawa (Sakai, Osaka, Tokyo, Okayama and Nishinomiya, JP) Diagnostic accuracy of pocket-size handheld echocardiographs used by cardiologists in the acute care setting. – A. Testuz, H. Muller, P.F. Keller, P. Meyer, T. Stampfli, L. Sekoranja, C. Vuille, H. Burri (Geneva, CH) Inter-vendor variability for measurements of left ventricular strain using two-dimensional speckle tracking analysis: a substudy of Japanese Ultrasound Speckle Tracking of the Left Ventricle (JUSTICE). – K. Takigiku, M. Takeuchi, S. Nakatani, C. Izumi, S. Yuda, K. Sakata, N. Ohte, K. Tanabe (Nagano, Kitakyushu, Osaka, Tenri, Sapporo, Tokyo, Nagoya and Izumo, JP) Usefulness of automated function imaging to detect myocardial ischemia during dipyridamole stress echocardiography. – C. Zito, M. Cusma-Piccione, S. Tripepi, M. Mohammad, G. Di Bella, G. Oreto, P. Crea, A. Madaffari, G. Falanga, S. Carerj (Messina, IT) Changes in left ventricular strain during exercise stress echocardiography in healthy subjects: a speckle tracking echocardiography study. – M. Cameli, F.M. Righini, M. Lisi, S. Benincasa, S. Mondillo (Siena, IT) P4858 P4859 P4860 P4861 P4862 P4863 P4864 P4865 CARDIOMYOPATHIES: GENETICS P4866 P4867 P4868 P4869 P4870 P4871 P4872 TUESDAY – AFTERNOON Hypertrophic cardiomyopathy in Iceland: MYBPC3 founder mutation? – B. Adalsteinsdottir, P. Teekakirikul, J.G. Seidman, C.E. Seidman, B.J. Maron, R. Danielsen, G.T. Gunnarsson (Reykjavik, IS; Boston and Minneapolis, US) Cause of cardiomyopathy in muscular dystrophy: genetically caused structural weakness vs. acquired myocarditis? Answers based on a siblings study. – H. Yildiz, E. Tanay, S. Roesch, U. Sechtem, A. Yilmaz (Stuttgart, DE) Phenotype-genotype correlation in patients with mutations in the beta-myosin converter domain. – D.A. Garcia-Giustiniani, X. Fernandez, M. Ortiz-Genga, R. Barriales-Villa, A. Mazzanti, I. Rodriguez, L. Cazon, M. Perez-Barbeito, E. Maneiro, L. Monserrat-Iglesias (A Coruña, ES) Is the gene MYOM2 encoding myomesin 2 involved in the pathogenesis of hypertrophic cardiomyopathy? – A. Perrot, A. Barton, B. Kherad, L.H. Boldt, W. Haverkamp, S. Rickert-Sperling (Berlin, DE) Unravelling mutation effects from secondary adaptations in cardiomyocytes of Familial Hypertrophic Cardiomyopathy patients. – T. Kraft, E.R. Paalberends, N.M. Boontje, S. Tripathi, J. Montag, A. Francino, F. Navarro-Lopez, B. Brenner, G.J.M. Stienen, J. Van Der Velden (Hannover, DE; Amsterdam, NL; Barcelona, ES) Lamin A/C mutation is independently associated with an increased risk of arterial and venous thromboembolic complications. – I.A.W. Van Rijsingen, A.J. Van Der Kooi, J.P. Van Tintelen, M.P. Van Den Berg, I. Christiaans, A.A.M. Wilde, J.C.M. Meijers, R. Nieuwland, Y.M. Pinto, S.J. Pinto-Sietsma (Amsterdam and Groningen, NL) New genetic determinants of disease phenotype in hypertrophic cardiomyopathy: high-throughput sequencing reveals unexpected complexicity. – L. Rocha Lopes, P. Syrris, M. Hubank, C. Giambartolomei, A. Zekavati, C. Dalageorgou, S. Jenkins, V. Plagnol, P.M. Elliott (London, GB) Missense mutations in titin-associated proteins identified in patients with dilated cardiomyopathy. – V. Ruppert, T. Meyer, S. Ackermann, A. Perrot, M. Posch, A. Richter, B. Maisch, S. Pankuweit (Marburg, Göttingen and Berlin, DE) Tei index, a useful indicator for right ventricular involvement in fabry disease. – H.A.C.M. Bruin De- Bon, B.E. Smid, B.J. Bouma, R.B.A. Van Der Brink, H.M. Eckmann, D.A. Samson, J. Vleugels, C.E. Hollak (Amsterdam, NL) Role of serum NT-proBNP measurement in the diagnosis of early cardiac involvement in patients with anderson-fabry disease. – C.J. Coats, V. Paresi, M. Ramos, K. Janagarajan, C. O’Mahony, A. Dawnay, A. Mehta, D. Hughes, P.M. Elliott (London, GB) Advanced left heart disease in cystic fibrosis: a distinct form of cardiomyopathy. – L. Ruiz Bautista, J. Segovia, C. Salas, C. Prados, L. Maiz, R. Giron, M.T. Martinez, S. Mingo, J. Mirelis, L.A. Alonso Pulpon (Madrid, ES) Cardiac autonomic nervous system dysfunction in a cardiomyopathy mouse experimental model. – N. Athanasiadis, M. Mavroidis, M. Katsiboulas, S. Nikolopoulos, I. Kostavassili, C. Dimitriou, Y. Capetanaki, C.H. Davos (Athens, GR) P4873 P4874 P4875 P4876 P4877 283 TUESDAY, 28 AUGUST 2012 – AFTERNOON POSTERS MYOCARDITIS Left ventricular mechanics in acute myocarditis Correlation of 2D speckle tracking deformation and rotation imaging with troponin release and cardiac magnetic resonance findings. – E. Nyktari, A. Patrianakos, E. Zacharis, G. Solidakis, F. Parthenakis, P.E. Vardas (Heraklion, GR) Adiponectin promotes coxsackievirus B3 myocarditis by controlling viral infection within the heart. – A. Jenke, J. Stehr, S. Wilk, A. Weithaeuser, K. Klingel, H.P. Schultheiss, C. Scheibenbogen, C. Skurk (Berlin and Tübingen, DE) Clinical presenting patterns and CMR features of acute myocarditis predicting outcome. – O.E. Rimoldi, D. Lanza, P. Pedrotti, A. Milazzo, S. Pedretti, A. Roghi (Milan and Verona, IT) In vivo delivery of adenoviral vector containing interleukin-17 receptor A reduces cardiac remodeling and improves myocardial function in CVB-3 -induced chronic myocarditis. – R. Chen, Y.Q. Xie, P. Chen, X. Zhang, M.H. Li, X.G. Wang, T.Q. Peng, Y.Z. Zou, H.Z. Chen, J.B. Ge (Shanghai, CN; Baltimore, US; London, CA) Relationship between cardiac magnetic resonance criteria for acute myocarditis and biomarkers of inflammation and myocardial damage. – G. Nucifora, A. Di Chiara, D. Miani, G. Piccoli, M. Puppato, G. Slavich, D. Gasparini, A. Proclemer (Udine and Tolmezzo, IT) Immunoglobulin suppressed autoimmune myocarditis in severe combined immunodeficient (SCID) mice by inducing T cell unresponsiveness. – C. Kishimoto, K. Shioji, Z. Yuan (Kyoto, JP; Xi’an, CN) Injectable collagen implant improves survival and early cardiac remodeling after fulminant myocarditis in rat. – S. Rinkevich-Shop, N. Landa-Rouben, R. Holbova, F.H. Epstein, T. Ben Mordechai, M.S. Feinberg, O. Goitein, T. Kushnir, E. Konen, J. Leor (Tel Hashomer, IL; University of Virginia, US) Matrix Metalloproteinase-13 is beneficial in viral myocarditis not only by preventing cardiac inflammation but also reducing cardiac inflammation due to regulating chemokines. – D. Westermann, D. Lindner, H.P. Schultheiss, C. Tschoepe (Berlin, DE) No evidence of adenoviral genome in endomyocardial biopsy specimens in patients with new-onset unexplained dilated cardiomyopathy. – T. Palecek, P. Kuchynka, E. Nemecek, J. Horak, T. Kovarnik, I. Vitkova, A. Linhart (Prague, CZ) Clinical, ECG and echocardiographic criteria are insufficient to reach a definite diagnosis in patients with myocardial injury and normal coronary angiogram: insights from magnetic resonance-based. – E. Perez-David, R. Colina, R. Yotti, M. Sanchez Alegre, J. Alarcon, J. De La Torre, A. Gonzalez Mansilla, J. Bermejo, F. Fernandez Aviles (Madrid, ES) Olmesartan, an angiotensin II type 1 receptor antagonist, suppresses cytotoxic myocardial injury in autoimmune heart failure. – C. Kishimoto, K. Shimada, Z. Yuan (Kyoto, JP; Xi’an, CN) Secretome from mononuclear cells confers immunosuppression in a murine autoimmune myocarditis model. – K. Hoetzenecker, M. Zimmermann, T. Schweiger, D. Kollmann, M. Mildner, A. Mitterbauer, P. Birner, M. Lichtenauer, H. Ankersmit (Vienna, AT) Etanrecept treatment improves acute chagas disease outcome but alters cardiac conduction and repolarization parameters. – H.O. Rodriguez Angulo, E.J. Castillo, E.J. Cardenas, J.A. Marques, A.J. Mijares (Caracas and Barquisimeto, VE) Diagnostic and prognostic value of biomarkers in suspected myocarditis. – C. Ukena, F. Mahfoud, M. Kindermann, J. Poess, P. Lepper, R. Kandolf, M. Böhm, I. Kindermann (Homburg, Saarbrücken and Tübingen, DE) P4878 P4879 P4880 P4881 P4882 P4883 P4884 P4885 P4886 P4887 P4888 P4889 P4890 P4891 MYOCARDIAL INVOLVEMENT IN SYSTEMIC DISEASES Measurement of interatrial dyssynchrony using tissue doppler imaging predicts functional capacity and cardiac involvement in systemic sclerosis. – J.-C. Eicher, S. Berthier, J.-L. Philip, B. Lorcerie, B. Bernard, J.-E. Wolf (Dijon, FR) Myocardial mechanics for the early detection of cardiac sarcoidosis. – C. Aggeli, I. Felekos, E. Gialafos, E. Poulidakis, A. Katsaros, E. Venieri, A. Rapti, C. Stefanadis (Athens, GR) Echocardiographic abnormalinies and their relation to exercise capacity in young unselected survivors of Hodgkin’s lymphoma late after mediastinal irradiation. – M.G. Poltavskaya, Y.V. Avdeev, I.V. Kuprina, S.B. Shornikov, A.L. Syrkin (Moscow, RU) Prevalence of cardiomyopathy in an unselected population of adult patients with cystic fibrosis. – L. Ruiz Bautista, J. Segovia, C. Prados, L. Maiz, R. Giron, M.T. Martinez, M. Gonzalez Estecha, S. Mingo, M. Pastrana, L.A. Alonso Pulpon (Madrid, ES) Adult patients with growth hormone deficiency have subclinical and related biventricular longitudinal dysfunction due to intrinsic myocardial disease. – S. Mihaila, R.C. Rimbas, R. Mincu, N. Patrascu, R.E. Dulgheru, R. Dragoi, R. Mihaila, C. Badiu, D. Vinereanu (Bucharest, RO) Impaired vascular elasticity and diastolic dysfunction in pseudoxanthoma elasticum. – L. Campens, O. Vanakker, B. Trachet, P. Segers, A. De Paepe, J. De Backer (Ghent, BE) Differential effect of antiretroviral drug regimens on aortic elastic properties in HIV infected individuals. – A. Synodinos, C. Vlachopoulos, P. Xaplanteris, H. Sambatakou, E. Mariolis, N. Ioakeimidis, D. Terentes-Printzios, D. Pektasidis, C. Stefanadis (Athens, GR) Study of heart involvement in kawasaki disease: a multicenter study. – Z.M. Amirimoghadam (Tehran, IR) 284 P4892 P4893 P4894 P4895 P4896 P4897 P4898 P4899 TUESDAY, 28 AUGUST 2012 – AFTERNOON POSTERS PULMONARY HYPERTENSION IMAGING Right ventricular 2D-strain: a new tool to follow up pulmonary hypertension patients under vasodilator therapy. – I. Garcia Lunar, S. Mingo, V. Monivas, C. Mitroi, M.A. Cavero, E. Gonzalez Lopez, M. Sanchez Garcia, M. Gomez Bueno, J. Segovia, L. Alonso Pulpon (Madrid, ES) Right ventricular remodeling in idiopathic pulmonary arterial hypertension with three-dimensional echocardiography and cardiac magnetic resonance. follow up within 2 years. – J. Grapsa, I.Z. Cabrita, D. Dawson, D. O’Regan, G. Durighel, L.S.G.E. Howard, J.S.R. Gibbs, P. Nihoyannopoulos (London, GB) Echocardiographic prognostic factors for mortality in pulmonary hypertension: way beyond tricuspid annular displacement. – I. Garcia Lunar, S. Mingo, V. Monivas, C. Mitroi, D. Garcia Cosio, J. Gonzalez Mirelis, M.A. Cavero, M. Gomez Bueno, J. Segovia, L. Alonso Pulpon (Madrid, ES) Echocardiography of pulmonary vascular function in asymptomatic carriers of the bone morphogenetic protein receptor type 2 mutation. – A.T. Pavelescu, R. Vanderpool, J.L. Vachiery, E. Grunig, R. Naeije (Brussels, BE; Heidelberg, DE) Survival in pre-capillary pulmonary hypertension: does echocardiography make the difference? – J. Grapsa, L.S.G.E. Howard, B.V. North, D. Dawson, M.F. Bellamy, J.S.R. Gibbs, P. Nihoyannopoulos (London, GB) Improving echocardiography estimation of right atrial pressure: comparison among several models and a new one based on right atrial evaluation. – C. Magnino, P. Omede, W. Grosso Marra, M. Chiarlo, D. Presutti, C. Bucca, C. Moretti, F. Gaita, F. Veglio, A. Milan (Turin, IT) An echocardiographic score for evaluating the pre-test probability of having a pre-capillary rather than a post-capillary pulmonary hypertension. – M. D’Alto, E. Romeo, P. Argiento, A. Correra, B. Sarubbi, N. Grimaldi, M. Pignatiello, A. Caronna, R. Calabro’, M.G. Russo (Naples, IT) Pulmonary artery trunk dilation in symptomatic subjects referred for coronary artery calcium scoring by means of a 64-raw cardiac computed tomography. – M. Sosnowski, A. Czekaj, B. Korzeniowska, R. Mlynarski, Z. Gasior, M. Tendera (Katowice, PL) Pulmonary vasculopathy assessed by intravascular ultrasound in patients with severe chronic respiratory failure evaluated for lung transplantation: comparation to pulmonary arterial hypertension. – E. Domingo Ribas, C.H. Arredondo Flores, N. Bouteldja, M. Vazquez, B. Garcia Del Blanco, M.L. Lopez, A. Roman Broto (Barcelona, ES) P4900 P4901 P4902 P4903 P4904 P4905 P4906 P4907 P4908 PULMONARY HYPERTENSION: MECHANISMS P4909 P4910 P4911 P4912 P4913 TUESDAY – AFTERNOON Egr-1 expression is specific for neointimal development in both human and experimental PAH. – M.G. Dickinson, B. Bartelds, M.A.J. Borgdorff, G. Molema, J. Sietsma, R.M.F. Berger (Groningen, NL) A female model of severe neointimal pulmonary hypertension: evidence for increased susceptibility in a female rat following pneumonectomy and monocrotaline? – R.J. White, D.F. Meoli, D. Haight, W. O’Dell, F. Ahmaad (Rochester, Gainesville and Pittsburgh, US) Increased pulmonary blood flow causes perivascular macrophage infiltration in experimental PAH. – M.G. Dickinson, B. Bartelds, M.A.J. Borgdorff, R.M.F. Berger (Groningen, NL) Nitrated fatty acids attenuate right ventricular dysfunction in hypoxia-induced pulmonary hypertension in mice. – T.K. Rudolph, A. Klinke, A. Moeller, T. Ravekes, K. Friedrichs, S. Blankenberg, V. Rudolph, S. Baldus (Hamburg, DE) Right ventricular hypertrophy and failure abolish cardioprotection by ischemic preconditioning. – A. Andersen, J.A. Povlsen, H.E. Boetker, J.E. Nielsen-Kudsk (Aarhus, DK) POPULATIONS GENETICS New single nucleotide polymorphisms associated with altered platelet response to acetylsalicylic acid in diabetic population: genome-wide association approach and pooled DNA strategy. – M. Postula, P.K. Janicki, M. Rosiak, A. Kaplon-Cieslicka, K.J. Flipiak, D.A. Kosior, G. Opolski (Warsawa and Warsaw, PL; Hershey, US) Impact of clinical and genetic factors on acenocoumarol dose requirements in Polish patients - dose calculation algorithm. – J. Wolkanin-Bartnik, H. Pogorzelska, M. Szperl, A. Bartnik (Warsaw, PL; London, GB) Low-frequency intermediate penetrance variants in the ROCK1 gene predispose to congenital heart disease. – J. Palomino Doza, A. Topf, J. Bentham, S. Bhattacharya, C. Cosgrove, J. Granados-Riveron, J. Goodship, D. Henderson, J. O’Sullivan, B.D. Keavney (Valladolid, ES; Newcastle-upon-Tyne, Oxford and Nottingham, GB) Influence of genetic polymorphisms of alpha-adrenergic receptors, endothelial nitric oxide synthase and bradykinin receptor B2 on treadmill exercise test responses. – R.A. Belo Nunes, L.P. Barroso, R.T. Schmidt, D.D. Barreto, H.F. Freitas, A.C. Pereira, J.E. Krieger, A.J. Mansur (São Paulo, BR) Association between a genetic variant near adrenomedullin gene with left ventricular mass index. – F. Beygui, P.S. Wild, T. Zeller, R. Castagne, T. Munzel, G. Montalescot, D.A. Tregouet, F. Cambien, L. Tiret, S. Blankenberg (Paris, FR; Mainz and Hamburg, DE) P4914 P4915 P4916 P4917 P4918 285 TUESDAY, 28 AUGUST 2012 – AFTERNOON POSTERS Systematic testing of literature reported genetic variation associated with restenosis after percutaneous coronary intervention: results of the genetic determinants of restenosis study. – J.J.W. Verschuren, S. Trompet, I. Postmus, M.L. Sampietro, B.T. Heijmans, J.J. Houwing-Duistermaat, E.P. Slagboom, J.W. Jukema (Leiden, NL) Chromosome 9p21.3 effect on CDKN2A/2B expression in human coronary atherosclerosis. – F. Notarangelo, N. Marziliano, L. Foco, R. Giacalone, C. Tardio, L. Coppini, F. Bontardelli, C. Berzuini, P.A. Merlini, D. Ardissino (Parma, Milan and Pavia, IT; Cambridge, GB) Gene expression profiling in patients with myocardial infarction at young age. – T. Zeller, C. Mueller, M.O. Scheinhardt, A. Schillert, R.B. Schnabel, P.S. Wild, K.J. Lackner, T. Munzel, A. Ziegler, S. Blankenberg (Hamburg, Lübeck and Mainz, DE) Synergistic effects of genetic variants of the apolipoprotein A-V gene and the butyrophilin, subfamily 2, member A1 gene on dyslipidemia in east Asian populations. – M. Oguri, Y. Shibata, H. Kamiya, M. Hiramatsu, H. Horibe, K. Kato, T. Murohara, J.H. Lee, Y. Jang, Y. Yamada (Nagoya, Tajimi and Tsu, JP; Seoul, KR) Genetic and non-genetic correlates of plasma MRproAdrenomedullin levels. – F. Beygui, P.S. Wild, T. Zeller, R. Castagne, T. Munzel, G. Montalescot, D.A. Tregouet, F. Cambien, S. Blankenberg, L. Tiret (Paris, FR; Mainz, DE) Genetic polymorphisms of CYP2C19 and effect of CYP2C19*2 allele on clopidogrel P2Y12 inhibition in healthy Malaysian volunteers. – Y.N. Sani, S.C. Lim, L.H. Lim, N.E.Y. Edwin, N. Abdul Karim Khan, T.H. Goh, V.L. Serebruany, K.H. Yuen (Penang, MY; Towson, US) Matrix metalloproteinase; investigation from gene to protein as effective factor in myocardial infarction. – A.S. Tabatabaei Panah, R. Akbarzadeh Najar, S.M.H. Ghaderian (Tehran, IR) Blood pressure and renal function in relation to A-173G polymorphism of the epithelial sodium channel gamma subunit (SCNN1G) on longitudinal observation in general population. – K. Stolarz-Skrzypek, A. Olszanecka, W. Wojciechowska, D. Czarnecka, K. Kawecka-Jaszcz (Krakow, PL) The CC variant (rs 1333049) of 9p21 influences the development of acute coronary disease, but not the stable angina and doesn’t imply worst coronary morphology. – R. Palma Dos Reis, M. Mendonca, B. Silva, A. Pereira, S. Gomes, H. Cafe, S. Freitas, G. Guerra, A. Brehm, J.J. Araujo (Lisbon and Funchal, PT) Influence of rs5065 atrial natriuretic peptide gene variant on Coronary Artery Disease. – E. Barbato, S.A. Sciarretta, J. Bartunek, F. Mangiacapra, D. Lambrechts, P. Sinnaeve, F. Van De Werf, K.A.A. Fox, M. Volpe, S.A. Rubattu (Aalst and Leuven, BE; Rome and Pozzilli, IT; Edinburgh, GB) Coronary artery disease risk polymorphisms in Latvian patients and population controls. – R. Peculis, G. Latkovskis, I. Kalnina, A. Erglis, J. Klovins (Riga, LV) P4919 P4920 P4921 P4922 P4923 P4924 P4925 P4926 P4927 P4928 P4929 GENETICS AND GENE THERAPY Cost-effectiveness of genetic studies in inherited cardiomyopathies. – M. Sabater, J.R. Gimeno, F. Ruiz-Espejo, E. Garcia-Molina, M.J. Oliva, P. Pascual, I. Gomez, I. Perez, I. Tovar, M. Valdes (Murcia, ES) Secretoneurin gene therapy reverses the impairment of hindlimb post-ischemic recovery in Apo E -/mice. – M. Theurl, K. Albrecht-Schgoer, W. Schgoer, I. Tancevski, R. Kirchmair (Innsbruck, AT) Early AAV9-mediated over-expression of S100A1 ameliorates myocardial hypertrophy in dystrophin-deficient mice. – R. Bauer, H. Enns, C. Volz, P. Most, H.A. Katus, O.J. Mueller (Heidelberg, DE) Adenovirus-Mediated gene transfer of a luciferase reporter gene by a cardiac-specific promoter through direct injection into the left ventricular wall. – Z. Xu, Z.X.T. Tao, Z.J.Y. Yang (Nanjing, CN) Post-infarct treatment with microRNA145 reduces myocardia infarct size and improves cardiac remodeling and function in rabbits. – K. Higashi, Y. Yamada, E. Horibe, K. Nishigaki, G. Takemura, Y. Akao, S. Minatoguchi (Gifu and Takayama, JP) Identification of AAV6 as most efficient vector for transvascular gene transfer into porcine myocardium based on an in vitro model for prediction of the cardiac gene transfer performance. – J. Ksienzyk, P. Raake, S. Schlegel, H.A. Katus, O.J. Mueller (Heidelberg, DE) R14Del, a Dutch phospholamban mutation in Spanish family. Genotype-phenotype aspects. – I. Gomez Milanes, E. Garcia-Molina, M. Sabater-Molina, I. Perez, J.M. Ayala, F. Ruiz-Espejo, D. Lopez Cuenca, P. Martinez, J.R. Gimeno, M. Valdes (Murcia, ES) Penetrance study in SCN5A-mutations in brugada syndrome. – E. Garcia-Molina, J. Lacunza, M. Sabater, P. Pascual, I. Gomez, D. Lopez-Cuenca, F. Ruiz-Espejo, J. Gimeno, I. Tovar, M. Valdes (Murcia, ES) Age-related penetrance in genetic carriers of hypertrophic cardiomyopathy. – I. Perez, A. Romero-Puche, M. Sabater-Molina, E. Garcia-Molina, I. Gomez-Milanes, D. Lopez-Cuenca, F. Ruiz-Espejo, J.R. Gimeno Jr, M. Valdes M (Murcia, ES) Association of a matrix metallopeptidase 1 gene polymorphism with long-term outcome of thoracic aortic aneurysm. – K. Kato, N. Inagaki, T. Fujimaki, M. Oguri, T. Hibino, K. Yokoi, T. Murohara, Y. Yamada (Tsu, Tajimi, Inabe and Nagoya, JP) 286 P4930 P4931 P4932 P4933 P4934 P4935 P4936 P4937 P4938 P4939 TUESDAY, 28 AUGUST 2012 – AFTERNOON POSTERS METABOLISM AND METABOLIC SYNDROME P4940 P4941 P4942 P4943 P4944 P4945 P4946 P4947 P4948 P4949 P4950 P4951 P4952 P4953 P4954 P4955 TUESDAY – AFTERNOON NO from neuronal NO synthase increases after beta-adrenergic stimulation but does not control mitochondrial respiration. – S. Bergem, M. Kohlhaas, A. Nickel, M. Meiser, M. Hohl, R. Carnicer, U. Laufs, M. Böhm, B. Casadei, C. Maack (Homburg/Saar, DE; Oxford, GB) The onset of type 2 diabetes protects the heart against ischaemia-reperfusion injury by shutdown of mitochondrial metabolism during early reperfusion. – J.A. Povlsen, B. Lofgren, C. Dalgas, R.D. Birkler, M. Johannsen, N.B. Stoettrup, H.E. Botker (Aarhus, DK) Obesity and metabolic syndrome aggravates myocardial diastolic dysfunction in obese spontaneously hypertensive rat. – D. Linz, M. Hohl, F. Mafhoud, J.S. Reil, W. Linz, T. Huebschle, H.P. Juretschke, C. Neumann-Haefelin, H. Ruetten, M. Böhm (Homburg and Frankfurt/Main, DE) Subclinical hyperthyroidism and cardiovascular mortality. – C. Selmer, J.B. Olesen, J.C. Madsen, U. Schmidt, J. Faber, P.R. Hansen, O.D. Pedersen, M.L. Hansen, C. Torp-Pedersen (Hellerup, Copenhagen, Herlev and Roskilde, DK) Endothelial Microparticles derived under high Glucose concentrations increase monocyte adhesion on endothelial cells through upregulation of adhesion proteins in a p38 dependent way. – X. Yang, F. Jansen, B. Franklin, T. Schmitz, H. Slomka, G. Nickenig, N. Werner (Bonn, DE) Effects of combined genotypes for polymorphisms of the apolipoprotein A-V gene and the butyrophilin, subfamily 2, member A1 gene on metabolic syndrome in east Asian populations. – M. Oguri, Y. Shibata, H. Kamiya, M. Hiramatsu, T. Fujimaki, K. Kato, T. Murohara, J.H. Lee, Y. Jang, Y. Yamada (Nagoya, Inabe and Tsu, JP; Seoul, KR) Clinical and prognostical implication of advanced glycation in acute coronary syndromes. – S. Raposeiras Roubin, B.K. Rodino Kostka, B. Paradela Dobarro, L. Grigorian Shamagian, J.M. Garcia Acuna, P. Aguiar Souto, M. Jacquet Hervet, M.V. Reino Maceiras, E. Alvarez Castro, J.R. Gonzalez-Juanatey (Santiago de Compostela and Vigo, ES) Acute cardiac ryanodine receptor loss-of-function leads to bradycardia, arrhythmia, heart failure and transcriptional metabolic reprogramming. – M.J. Bround, R. Wambolt, P. Asghari, D.S. Luciani, F. Taghizadeh, J. Kulpa, K.R. Boheler, E.D.W. Moore, M.F. Allard, J.D. Johnson (Vancouver, CA; Baltimore, US) Genetic deficiency of corticotropin releasing hormone influences cardiac function through fatty acid metabolism. – T. Tzanavari, A. Varela, S. Theocharis, C. Pantos, D. Cokkinos, K.P. Karalis (Athens, GR) CD40L deficiency ameliorates diet-induced adipose tissue inflammation, but does not protect from insulin resistance and hepatic steatosis in mice. – D. Wolf, F. Jehle, P. Stachon, F. Willecke, C. Bode, K. Peter, A. Zirlik (Freiburg, DE; Melbourne, AU) Stress-induced adipose inflammation promotes a procoagulant state and impairs insulin sensitivity by adipocyte-derived monocyte chemoattractant protein-1. – Y. Uchida, K. Takeshita, R. Kikuchi, T. Murohara (Nagoya, JP) Chronic consumption of reheated vegetable oils increases cardiometabolic risk factors. – O. Perez-Mendez, Y. Komera-Arenas, R. Bautista-Perez, A. Aranda-Fraustro, J. Vargas-Barron, M. Franco (Mexico City, MX) Significant association of the CYP27A1 polymorphism with adipocytokines, cholesterol profiles and metabolic syndrome in middle-aged male. – K.-H. Cheng, C.-C. Liu, C.-N. Huang, Y.-C. Lee, C.-S. Chu, E. Hsi, W.-T. Lai, S.-P. Huang (Kaohsiung, TW) The heme oxygenase system reduces pericardial adiposity and improves diabetic cardiomyopathy in zucker diabetic fatty rats. – J.F. Ndisang (Saskatoon, CA) Synergistic effect of human immunodeficiency virus and the metabolic syndrome on arterial stiffness. – M. Asaad, O.J. Rider, N. Ntusi, R. Banerjee, G. Hancock, G. Clutton, E. Wainwright, L. Dorrell, K. Clarke, C. Holloway (Oxford, GB) The metabolic syndrome significantly affects the association between resting heart rate and all cause as well as cardiovascular mortality. – A. Vonbank, F. Schmid, P. Rein, C.H. Saely, H. Drexel (Fedlkirch, AT; St. Gallen, CH; Philadelphia, US) Increased expression of tissue factor in intra-abdominal adipose tissue in a metabolic syndrome model: a new link between metabolic syndrome and atherosclerosis? – L. Pasquesoone, D. Corseaux, A. Elkalioubie, B. Joke, A. Ung, N. Grossin, C. Banfi, B. Jude, S. Susen, E. Van Belle (Lille, FR) Exercise affects insulin sensitivity in HCR and LCR-rats differentially. – M. Schwarzer, A. Molis, A. Schrepper, T. Doenst (Jena, DE) Multi compartment body composition analysis in chronic heart failure: air displacement plethysmography, body impedance analysis, dual-x-ray-absorptiometry, and 3d-white light scan analysis. – T.D. Trippel, A. Stahn, V. Tscholl, S. Inkrot, W. Doehner, S. Von Haehling, E. Tahirovic, W. Haverkamp, H.D. Duengen, D. Obradovic (Berlin, DE) Early-induced overweight causes rapid changes in heart genomic expression and long-term cardiovascular, metabolic and oxidative alteration. – A. Habbout, J. Lorin, E. Rigal, C. Fassot, L. Rochette, C. Vergely (Dijon and Angers, FR) Longitudinal study of Advanced Glycation End product plasma levels in patients undergoing coronary artery bypass grafting surgery: effects of statin treatment, gender and type-2 diabetes. – V. Salpeas, J.N. Tsoporis, G. Proteau, S. Izhar, E. Sakadakis, T.G. Parker, I.A. Rizos, M. Anastasiou-Nana (Athens, GR; Toronto, CA) Increased expression of miRNA-223 during early reperfusion with ischemic postconditioning in pigs. – T. Baars, A. Skyschally, G. Heusch, P. Kleinbongard (Essen, DE) P4956 P4957 P4958 P4959 P4960 P4961 (W) 287 TUESDAY, 28 AUGUST 2012 – AFTERNOON POSTERS FULL APPRAISAL OF GLYCEMIC RISK The DPP-IV inhibitor sitagliptin improves beta-cell function in patients with acute coronary syndromes and newly diagnosed glucose abnormalities. – C. Hage, K.B. Brismar, S.E. Efendic, P.L. Lundman, L.R. Ryden, L.G.M. Mellbin (Stockholm, SE) Detection of subclinical left ventricular dysfunction in asymptomatic young adults with type-2 diabetes: a cardiac magnetic resonance study. – J.N. Khan, E. Wilmot, M. Davies, T. Gorely, K. Khunti, M. Leggate, M. Nimmo, A. Singh, T. Yates, G.P. Mccann (Leicester and Loughborough, GB) National cardiovascular risk assessment in type 2 diabetes in China. – D.A.Y.I. Hu, L.N. Ji, C.S. Ma, Y. Huo, C.Y. Pan, G.W. Li, H.J. Zhuo, D. Zhang (Beijing and Shanghai, CN) Heart rate variability, postprandial responses of glucose and insulin and beta-cell function: the NEO study. – S. Hillebrand, K.B. Gast, C.A. Swenne, J.W. Jukema, J.W.A. Smit, F.R. Rosendaal, M. Den Heijer, R. De Mutsert (Leiden and Amsterdam, NL) Diabetes is related to higher central blood pressure. – D. Debicka-Dabrowska, P. Jankowski, M. Kloch-Badelek, J. Wilinski, M. Brzozowska-Kiszka, K. Kawecka-Jaszcz, D. Czarnecka (Krakow, PL) Omentin-1concentrations predict 10-year incidence of diabetes in Thai: the EGAT study, 1998-2008. – D. Warodomwichit, W. Chaiyaratana, N. Thongmuang, M. Vanichapuntu, P. Sritara (Bangkok, TH) Impaired glucose homeostasis in non-diabetic hypertensives with family history of diabetes. – C. Liakos, G. Vyssoulis, E. Karpanou, A. Michaelides, C. Stefanadis (Athens, GR) Current smoking and prediabetes in young and healthy adults. – S. Aeschbacher, T. Schoen, M. Risch, L. Risch, D. Conen (Basel, CH; Schaan, LI) Membrane type 1-matrix metalloproteinase correlates with the coronary plaque stability in patients with postprandial hyperglycemia. – H. Uzui, M. Yamamoto, A. Nakano, Y. Mitsuke, T. Geshi, N. Amaya, K. Ishida, T. Morishita, Y. Fukuoka, J.D. Lee (Fukui, JP) Prognostic impact of concurrence of metabolic syndrome and chronic kidney disease in patients undergoing coronary intervention; involvement of coronary plaque morphology. – A. Kunimura, T. Amano, K. Kitagwa, Y. Shimbo, H. Ando, K. Harada, T. Yoshida, T. Uetani, T. Matsubara, T. Murohara (Nagoya, JP) A dipeptidyl peptidase-4 inhibitor, alogliptin, improves postprandial triglycemia and postprandial endothelial dysfunction. – Y. Noda, T. Miyoshi, H. Oe, Y. Ohno, K. Nakamura, H. Morita, K. Kohno, T. Toh, K. Kusano, H. Ito (Okayama, JP) 7-year reduction of exercise max heart rate predicts new onset diabetes. – K. Engeseth, P.T. Skretteberg, I. Grundvold, K. Liestoel, G. Erikssen, J. Erikssen, S.E. Kjeldsen, J. Bodegard (Oslo, NO) Metabolic syndrome in the Czech population. Current status and trends. – J. Bruthans, R. Cifkova, Z. Skodova, Z. Adamkova, M. Jozifova, P. Wohlfarth, M. Galovcova, V. Lanska (Prague, CZ) Autonomic neuropathy is independently associated with new heart failure and atrial fibrillation in diabetic patients with preserved ejection fraction: prognostic significance of heart rate recovery. – K. Negishi, S. Seicean, T. Negishi, T. Yingchoncharoen, C. Gibby, T. Marwick (Cleveland, US) Tight glycemic control after cardiac surgery reduces the incidence of post-surgical atrial fibrillation regardless of existence of diabetes mellitus. – A. Yoshida, H. Adachi, J. Tomono, N. Koike, S. Oshima (Maebashi, JP) Low levels of IgM antibodies against phosphorylcholine are not associated with glucometabolic disturbances in patients with acute ST-elevation myocardial infarction. – E.C. Knudsen, I. Seljeflot, C. Muller, G.O. Andersen (Oslo, NO) Chemerin is associated with the metabolic syndrome but is not linked to angiographically determined coronary artery disease. – C.H. Saely, A. Muendlein, A. Vonbank, K. Geiger, P. Rein, H. Drexel (St. Gallen, CH; Feldkirch and Fedlkirch, AT; Triesen, LI; Philadelphia, US) The J-shaped relationship between coffee consumption and prevalence of diabetes mellitus in elderly individuals. Ikaria study. – C. Chrysohoou, C. Masoura, G. Vogiatzi, S. Lagoudakou, S. Kyvelou, N. Galiatsatos, E. Zoulia, S. Mamatas, C. Pitsavos, C. Stefanadis (Athens, GR) Comparable effects of pioglitazone and perindopril on circulating endothelial progenitor cells, inflammatory process and oxidative stress in patients with diabetes mellitus. – A.M. Kampoli, D. Tousoulis, N. Papageorgiou, Z. Pallantza, G. Paterakis, A. Miliou, G. Roulia, E. Androulakis, C. Antoniades, C. Stefanadis (Athens, GR) Copeptin and adrenomedullin in a large cohort of catheterisation laboratory patients with newly detected diabetes or impaired glucose tolerance: the Silent Diabetes Study. – R. Doerr, J. Stumpf, S.G. Spitzer, B. Krosse, S. Kusche, T. Lohmann, O. Hartmann, N. Morgenthaler, D. Tschoepe, O. Schnell (Dresden, Hennigsdorf, Bad Oeynhausen and Munich, DE) Impact of exercise training on waist circumference, glucose metabolism and endothelial function in pre-diabetic, adipose patients with severe coronary heart disease. – E.B. Beck, F.J. Woitek, S. Erbs, R. Hoellriegel, V. Adams, M. Blueher, M. Stumvoll, F.W. Mohr, G. Schuler, A. Linke (Leipzig, DE) 288 P4962 P4963 P4964 P4965 P4966 P4967 P4968 P4969 P4970 P4971 P4972 P4973 P4974 P4975 P4976 P4977 P4978 P4979 P4980 P4981 P4982 TUESDAY, 28 AUGUST 2012 – AFTERNOON POSTERS P4983 P4984 P4985 P4986 P4987 P4988 P4989 P4990 P4991 P4992 P4993 P4994 P4995 P4996 P4997 TUESDAY – AFTERNOON Higher incidence of hypoglycaemia under oral anti-diabetic therapy in patients with type 2 diabetes and manifest vascular disease: 12-months follow-up of DiaRegis. – A.K. Gitt, P. Bramlage, E. Deeg, C. Binz, M. Krekler, D. Tschoepe (Ludwigshafen, Mahlow, Munich and Bad Oeynhausen, DE) Comparison between the effects of ivabradine and atenolol on heart rate variability in type II diabetic patients. – R. Nerla, M. Milo, G. Careri, P. Tarzia, G. Scavone, F. Zaccardi, D. Pitocco, G. Ghirlanda, G.A. Lanza, F. Crea (Rome, IT) Hyperglycaemia-induced oxidative stress mediates monocyte dysfunction in diabetes mellitus. – R. Godfrey, F.-D. Boehmer, J. Waltenberger (Münster and Jena, DE) Low rate of LDL-cholesterol target achievement in patients with type 2 diabetes with and without manifest vascular disease in Germany: results of DiaRegis. – A.K. Gitt, P. Bramlage, E. Deeg, C. Binz, M.G. Krekler, D. Tschoepe (Ludwigshafen, Mahlow, Munich and Bad Oeynhausen, DE) Can we predict the risk of glucose metabolism abnormalities in patients with previous percutaneous coronary intervention? – S.B. Baptista, P. Magno, C. Monteiro, E. Lourenco, P.F. Abreu, V. Gil (Amadora, PT) The impact of diabetes mellitus according to gender difference on acetylcholine induced coronary artery spasm. – S.W. Rha, J.Y. Park, S.K. Ryu, J.W. Choi, B.G. Choi, A. Elnagar, S.I. Im, S.W. Kim, C.U. Choi, D.J. Oh (Seoul, KR) Girls and boys with type 1 diabetes mellitus show different pathophysiology in premature atherosclerosis assessed by carotid-intima media thickness. – K. Nagl, B. Rami, E. Schober, A. Willfort-Ehringer, G. Schernthaner, T. Hoertenhuber, G.-H. Schernthaner (Vienna, AT) Prognostic impact of diabetes mellitus and hypertension for mid-term outcome of patients with Acute Myocardial Infarction in the era of Percutaneous Coronary Intervention. – M.G. Lee, M.H. Jeong, M.J. Kim, K.H. Lee, K.H. Park, D.S. Sim, Y.J. Hong, J.H. Kim, Y. Ahn (Gwangju, KR) The influence of anemia on long-term prognosis in patients with acute myocardial infarction and concomitant glucose abnormalities. – M. Mazurek, J. Kowalczyk, R. Lenarczyk, T. Kurek, A. Swiatkowski, E. Jedrzejczyk-Patej, J. Gumprecht, K. Strojek, L. Polonski, Z. Kalarus (Zabrze, PL) Genetic variability of sCD40L reveals a novel pathophysiological role of sCD40L in insulin resistance, in advanced atherosclerosis. – A. Miliou, C. Antoniades, C. Bakogiannis, D. Tousoulis, A.S. Antonopoulos, M. Demosthenous, M. Margaritis, K. Marinou, C. Psarros, C. Stefanadis (Athens, GR) Components of the interleukin-6 transsignalling system are associated with the metabolic syndrome, endothelial dysfunction and arterial stiffness. – T.W. Weiss, H. Arnesen, I. Seljeflot (Oslo, NO) Genetic Susceptibility to type II Diabetes in a Portuguese population. – M. Mendonca, S. Gomes, B. Silva, A. Pereira, A.C. Sousa, H. Cafe, S. Freitas, G. Guerra, J.J. Araujo, R. Palma Dos Reis (Funchal and Lisbon, PT) Determinants of the presence and extent of coronary artery disease in patients with type 2 diabetes and nondiabetic subjects. – A. Bechlioulis, K. Marini, K. Vakalis, M. Bougiaklli, S. Giannitsi, K. Nikolaou, K.K. Naka, G. Triantis, D. Sionis, L.K. Michalis (Ioannina and Athens, GR) Predictors of long-term cardiovascular outcomes in patients with type 2 diabetes mellitus. – H. Bianco, T. Helfenstein, M.C. Izar, H.A. Fonseca, S.C. Fischer, C.E. Ferreira, H.T. Xavier, R.M. Povoa, F.A. Fonseca (São Paulo and Santos, BR) The association of the A3872G polymorphism with hs-c-reactive protein levels and peripheral arterial disease in patients with type 2 diabetes mellitus. – S. Papaoikonomou, D. Tousoulis, N. Tentolouris, D. Papadogiannis, A. Miliou, G. Hatzis, N. Papageorgiou, C. Stefanadis (Athens, GR) Metabolic syndrome predicts incidence of coronary artery disease but not stroke in essential hypertension: data from a Greek 6-year-follow-up study. – K. Dimitriadis, C. Tsioufis, A. Kasiakogias, I. Anastasopoulos, P. Hatzigiannis, T. Katsimichas, V. Tzamou, K. Kintis, C. Thomopoulos, C. Stefanadis (Athens, GR) One-third of patients with diabetes mellitus do not have subclinical coronary atherosclerosis. – M.L. Tofterup, O. Gerke, K. Egstrup, N.P.R. Sand, H. Munkholm, H. Mickley, A.C. Diederichsen (Odense, Svendborg, Esbjerg and Vejle, DK) Arterial elastic wall properties are similarly impaired in first degree relatives and diabetic patients on the grounds of significant insulin resistance. – I. Ikonomidis, V. Lambadiari, C. Koukoulis, F. Kousathana, T. Papadema, M. Varoudi, V. Tritakis, H. Triantafyllidi, G. Dimitriadis, J. Lekakis (Athens, GR) Suboptimal LDL-cholesterol control by atorvastatin monotherapy in high-risk patients with coronary heart disease or atherosclerotic vascular disease in the UK. – Q. Zhang, C. Zhao, D. Ramey, M.J. Davies, A.M. Tershakovec (Whitehouse Station, US) Evaluation of the relationship between aortic elasticity and insulin sensitivity in healthy subjects with a normal carbohydrate metabolism. – R. Takacs, A. Nemes, H. Gavaller, A. Orosz, T. Varkonyi, I. Foldesi, T. Wittmann, T. Forster, C. Lengyel (Szeged, HU) Type 2 diabetes and the progression of visualized atherosclerosis to clinical cardiovascular events. – C.H. Saely, P. Rein, A. Vonbank, K. Huber, H. Drexel (St. Gallen, CH; Fedlkirch and Vienna, AT; Philadelphia, US) P4998 P4999 P5000 P5001 P5002 P5003 289 TUESDAY, 28 AUGUST 2012 – AFTERNOON POSTERS Preliminary observations of passive exercise using whole body periodic acceleration on coronary microcirculation and glucose tolerance in patients with type 2 diabetes. – M. Sakaguchi, S. Fukuda, K. Shimada, Y. Izumi, Y. Izumiya, Y. Nakamura, H. Ogawa, M. Fujita, J. Yoshikawa, M. Yoshiyama (Osaka, Kumamoto, Kyoto and Nishinomiya, JP) A novel anti-inflammatory adipokine, secreted frizzled-related protein 5, is associated with coronary artery disease in non-elderly population. – T. Miyoshi, M. Doi, M. Iwamoto, M. Kajiya, K. Nosaka, R. Nakayama, K. Takeda, S. Hirohata, S. Kusachi, H. Ito (Okayama and Takamatsu, JP) Predictors of Hypoglycaemia in patients with Type-2 Diabetes - an Analysis of the Prospective DiaRegis Registry. – D. Tschoepe, P. Bramlage, C. Binz, M. Krekler, E. Deeg, A.K. Gitt (Bad Oeynhausen, Mahlow, Munich and Ludwigshafen, DE) Blood pressure response to exercise is exaggerated in normotensive diabetic patients. – M.G. Kaya, Y. Karavelioglu, M. Akpek, H. Karapinar, I. Gul, Z. Kucukdurmaz, A. Yilmaz (Kayseri and Sivas, TR) Serum adiponectin is a negative predictor of incident metabolic syndrome: a population-based follow-up study. – S.V. Ahn, J.Y. Kim, J.K. Park, S.B. Koh (Wonju, KR) Impact of a cardiac diabetic nurse in reducing the incidence of hypoglycaemic events in cardiac patients with type 2 diabetes mellitus. – H. Eid, M.B. Bdeir, A. Fatouh, M. Ghidan, T. Conboy (Riyadh, SA) Non-dipping heart rate and microalbuminuria in a type 2 diabetic population. – C.J. Magri, R.G. Xuereb, S. Fava (Msida, MT) P5004 P5005 P5006 P5007 P5008 P5009 P5010 TAKING INTO ACCOUNT THE ECONOMIC CRISIS IN CARDIOLOGY Cost-effectiveness of cardiac resynchronization therapy in combination with an implantable cardioverter defibrillator in mild heart failure based on Markov modeling using UK cost approach in MADIT CRT. – V. Kutyifa, P. Aidelsburger, S. Schauer, B. Merkely, H. Klein, M. Kuniss, A. Kloppe, T. Kayser, R. Peppa, A.J. Moss (Budapest, HU; Sauerlach, Bad Nauheim and Lüdenscheid, DE; Rochester, US; Brussels, BE) Cost-effectiveness of the molecular autopsy in sudden unexplained death in the young. – J. Ingles, C. Semsarian (Sydney, AU) Economic analysis of the randomised assessment of treatment using panel assay of cardiac markers contemporary biomarker evaluation study (RATPAC CBE). – P. Collinson, D. Gaze, P. Thokala, S. Goodacre (London and Sheffield, GB) P5011 P5012 P5013 THE USE OF STATISTICS TO IMPROVE CARDIOVASCULAR CARE Evolution of the incidence of myocardial infarction in France 2002-2008: the “younger women paradox”. – C. De Peretti, F. Chin, P. Tuppin, N. Danchin (St. Maurice and Paris, FR) Discharge status of atrial fibrillation patients hospitalized for ischemic or hemorrhagic stroke in the United States. – T. Simon, X. Pan, A. Kuznik (Princeton and New York, US) Evidence-based medicine in the clinical practice guidelines of the European Society of Cardiology. – A. Ciszewski, M. Kosek, K. Lech, L. Malek, C. Kepka (Warsaw, PL) A retrospective cohort of long term all-cause mortality and recurrent cardiovascular events in patients with acute coronary syndrome in Thailand. – V. Thirawuth, T. Tangcharoen, P. Vathesatogkit, S. Yamwong, P. Sritara (Bangkok, TH) P5014 P5015 P5016 P5017 AMBULATORY BLOOD PRESSURE MONITORING: FOCUS ON NOCTURNAL BLOOD PRESSURE Non-dipping pattern in untreated hypertensive patients is related to increased pulse wave velocity independent of raised nocturnal blood pressure. – T. Erdogan, Y. Cicek, M.E. Durakoglugil, M. Cetin, A. Temiz, Y. Ugurlu, A. Canga (Rize, TR) Ambulatory blood pressure monitoring affects sleep quality and blood pressure. – V. Katsi, G. Souretis, S. Veioglanis, T. Gialernios, D. Tousoulis, C. Stefanadis, I. Kallikazaros (Athens, GR) The relation between serotonin levels and insufficient blood pressure decrease during night-time in hypertensive patients. – M.G. Kaya, R. Topsakal, N. Kalay, E. Gunturk, A. Dogan, M.T. Inanc, M. Yarlioglues, A. Ergin (Kayseri, TR) Circadian variation of blood Pressure is impaired in normotensive pregnant women with gestational diabetes mellitus. – E. Soydinc, V. Davutoglu, E. Sak, S. Evsen, H. Kaya, S. Ercan, I. Sari (Diyarbakir and Gaziantep, TR) Dipping status is characterized by augmented administration of benzodiazepines and elevated arterial stiffness. – V. Katsi, G. Souretis, I. Vlasseros, D. Vrachatis, D. Tousoulis, C. Stefanadis, I. Kallikazaros (Athens, GR) Incremental effects of restless legs syndrome (RLS) on nocturnal blood pressure in relatively young untreated hypertensive patients and normotensive individuals. – I. Erden, E. Cakcak Erden, Y. Turker, Y. Aslantas, H. Tibilli (Duzce, TR) Inverse dose-response association between urinary melatonin excretion and nocturnal systolic blood pressure in the elderly. – K. Obayashi, K. Saeki, J. Iwamoto, N. Okamoto, K. Tomioka, S. Nezu, Y. Ikada, N. Kurumatani (Nara and Mie, JP) Characterization of isolated nocturnal hypertension in adolescents. – E. Silva, G. Bermudez, J.J. Villasmil, A. Gonzalez, M. Bracho, C. Esis (Maracaibo, VE) 290 P5018 P5019 P5020 P5021 P5022 P5023 P5024 P5025 TUESDAY, 28 AUGUST 2012 – AFTERNOON POSTERS AMBULATORY BLOOD PRESSURE MONITORING AND TARGET ORGAN DAMAGE Abnormal blood pressure rise post mild exercise protocol in newly diagnosed hypertensive subjects is associated with significant cardiovascular functional/structural abnormalities. – M. El Shahawy, M. Entcheva (Sarasota, US) Does blood pressure variability influence the left ventricle mass index in patients with primary arterial hypertension? – M. Kurpesa, M. Zajac, E. Trzos, B. Uznanska-Loch, U. Cieslik-Guerra, T. Rechcinski, J.D. Kasprzak (Lodz, PL) Combined effects of blood pressure and aldosterone on cardiac left ventricular mass - ethnic differences between Han, Kazakh and Uygur subjects. – M. Ota, Y. Kasamaki, Y. Ozawa, A. Hirayama, T. Nakayama, H. Kawamura, D. Himit, A. Fukuda, M. Asano, Y. Izumi (Tokyo and Kanazawa, JP; Urumuqi, CN) Ambulatory blood pressure monitoring in hypertensive patients with chronic kidney disease. – M. Derevjanchenko, M.E. Statsenko (Volgograd, RU) The association of mean platelet volume levels with subclinic target organ damage in asymptomatic hypertensives. – M.G. Kaya, M. Yarlioglues, E. Gunturk, M. Akpek, R. Topsakal (Kayseri, TR) Diastolic but not systolic blood pressure was more significantly affected by the gender in newly diagnosed hypertensive patients with obesity. – H.J. Yoon, Y.K. Ahn, K.H. Kim, J.C. Park, J.B. Park, J.H. Bae, S.J. Rim, H.J. Youn, J. Kwon, S.W. Park (Gwangju, Seoul, Daejeon and Incheon, KR) Antihypertensive treatment less efficacious when evaluated by Ambulatory Blood Pressure Monitoring. – V. Gjini, G. Gjini (Fier, AL) P5026 P5027 P5028 P5029 P5030 P5031 P5032 AMBULATORY BLOOD PRESSURE MONITORING P5033 P5034 P5035 P5036 P5037 P5038 P5039 P5040 P5041 TUESDAY – AFTERNOON Masked hypertension and atherogenesis: the impact on apelin and relaxin plasma levels. – D. Papadopoulos, O. Papazachou, I. Mourouzis, A. Kotrotsou, M. Daskalaki, C. Thomopoulos, E. Sanidas, D. Perrea, T.H. Makris (Athens, GR) The prevalance of masked hypertension and blood pressure variability in patients with renal transplantation. – M. Kayrak, E.E. Gul, C. Kaya, K. Turkmen, Y. Solak, R. Yazici, I. Gul, L. Altintepe, S. Turk, K. Ozdemir (Konya and Samsun, TR) Impact of nocturnal continuous positive airway pressure therapy on ambulatory blood pressure in patients with obstructive sleep apnea and prehypertension. – H. Yorgun, G. Kabakci, E. Kirmizigul, U. Canpolat, A.H. Ates, E.B. Kaya, K. Aytemir, A.U. Demir, L. Tokgozoglu, A. Oto (Ankara, TR) Metabolic syndrome increases morning blood pressure surge. – E. Chatzistamatiou, G. Moustakas, E. Androulakis, D. Tousoulis, A. Avgeropoulou, N. Kalovidouris, M. Divani, C. Liakos, C. Stefanadis, I. Kallikazaros (Athens, GR) A novel non-invasive continuous system for estimating arterial blood pressure: first-in-man clinical results. – S. Bras, D. Ribeiro, J.P. Silva Cunha, R. Fontes-Carvalho (Aveiro and Vila Nova de Gaia, PT) Establishment of reference values for central blood pressure estimated by Omron HEM-9000AI. – S. Tanaka, H. Takase, T. Sugiura, S. Yamashita, Y. Dohi, G. Kimura (Nagoya and Hamamatsu, JP) Enhanced external counterpulsation has no lasting effect on blood pressure. – O. May, W.A.M. Khair (Herning, DK) Effect of atmospheric pressure on blood pressure. – U.I. Cieslik-Guerra, M. Kaminski, J. Chlapinski, W. Maranda, M. Piotrowicz, E. Trzos, B. Uznanska-Loch, T. Rechcinski, M. Kurpesa, A. Napieralski (Lodz, PL) Reproducibility of ambulatory blood pressure monitoring in patients with coronary heart disease. – S. Roas, I. Sudano, F. Enseleit, P. Kaiser, A. Hirt, T.F. Luscher, F. Ruschitzka, G. Noll (Zurich, CH) ST-ELEVATION MYOCARDIAL INFARCTION – FROM RISK STRATIFICATION TO THERAPEUTIC STRATEGIES Comparison of CRUSADE and ACUITY-HORIZONS risk scores for bleeding prediction in STEMI. – D. Couto-Mallon, X. Flores Rios, J. Rodriguez-Garrido, M. Garcia-Guimaraes, P. Gargallo-Fernandez, P. Pinon-Esteban, G. Aldama-Lopez, R. Calvino-Santos, N. Vazquez-Gonzalez, A. Castro-Beiras (Corunna, ES) Real-world primary PCI with bivalirudin: a report from the prospective, multi-centric EUROVISION registry. – U. Limbruno, A. Picchi, S. Hassani, S. Galli, B. Cortese, K. Huber, J. Lipiecki, F. Paganelli, M. Sangiorgi, M. Hamon (Grosseto, Milan, Bergamo and Rome, IT; Niort, Clermont-Ferrand, Marseille and Caen, FR; Vienna, AT) Impact of one versus multiple heparins administration on clinical outcome after primary PCI for STEMI: a prespecified analysis of the ATOLL trial. – J.-P. Collet, U.Z. Zeymer, C.P. Pollack, M. Cohen, K. Huber, P. Goldstein, J. Silvain, M. Aout, E. Vicaut, G. Montalescot (Paris and Lille, FR; Ludwigshafen, DE; Philadelphia and Newark, US; Vienna, AT) Manual thrombus aspiration reduces plaque volume in non-ST elevation acute coronary syndromes: the reduction of myocardial necrosis achieved with nose-dive manual thrombus aspiration study. – B. Ruggieri, M. Zimarino, F. Angeramo, S. Malatesta, F. Imola, F. Prati, A. Marchetti, R. De Caterina (Chieti and Rome, IT) P5042 P5043 P5044 P5045 291 TUESDAY, 28 AUGUST 2012 – AFTERNOON POSTERS Evidence for benefit of ischemic post-conditioning in optimally treated patients with myocardial P5046 infarction. – H. Thibault, S. Soukeur, C. Bergerot, L. Ernande, M. Altmann, P. Croisille, M. Ovize, G. Derumeaux (Lyon and Saint Etienne, FR) Coronary revascularization in patients that become stable. P5047 – O. Manfrini, M. Eskola, P. Karhunen, B. Xhyheri, K. Niemela, C. Pizzi, H. Huhtala, K. Nikus, R. Bugiardini (Bologna, IT; Tampere, FI) Enoxaparin is superior to unfractionated heparin in primary PCI for STEMI: results of the prespecified P5048 per-protocol analysis of the ATOLL trial. – J.-P. Collet, P. Ecollan, U. Zeymer, M. Cohen, P. Goldstein, C. Pollack, K. Huber, M. Aout, E. Vicaut, G. Montalescot (Paris and Lille, FR; Ludwigshafen, DE; Newark and Philadelphia, US; Vienna, AT) Effect of mechanical ischemic post-conditioning and thrombus aspiration on microvascular obstruction in P5049 patients with acute ST-segment elevation myocardial infarction. – N. Mewton, O. Lairez, F. Roubille, G. Rioufol, D. Angoulvant, I. Sanchez, C. Bergerot, I. Sahraoui, P. Croisille, M. Ovize (Bron, Toulouse, Montpellier and Lyon, FR) Addition of ivabradine during beta-blockers titration improves systolic and diastolic LV function in P5050 patients with recent Q-wave myocardial infarction. – Y.A. Lutay, A.N. Parkhomenko, O.I. Irkin, A.A. Stepura (Kiev, UA) The utility of thrombectomy and distal protection in patients with ST-segment elevation myocardial P5051 infarction showing poor coronary artery flow prior to primary percutaneous coronary intervention. – N. Suzuki, K. Kozuma, K. Tanabe, T. Muramatsu, Y. Ikari, T. Isshiki (Tokyo, Yokohama and Isehara, JP) Chronic intermittent pacing therapy amends infarct geometry and composition. P5052 – A. Uitterdijk, T. Springeling, V.J. De Beer, E. Mokelke, W.M. Blankesteijn, E.P. Doskalopoulos, F.W. Prinzen, R.J. Van Geuns, W.J. Van Der Giessen, D.J. Duncker (Rotterdam and Maastricht, NL; St. Paul, US) Gender differences in major bleeding with bivalirudin versus heparin during primary PCI in Acute P5053 Myocardial Infarction: results from the HORIZONS-AMI trial. – J. Yu, R. Mehran, L. Grinfeld, K. Xu, M. Fahy, E. Nikolsky, B.R. Brodie, A.J. Lansky, G.D. Dangas, G.W. Stone (New York, Greensboro and New Haven, US; Buenos Aires, AR; Haifa, IL) ADVANCES IN NON-ST ELEVATION MYOCARDIAL INFARCTION ACUTE CORONARY SYNDROMES – DIAGNOSTICS AND TREATMENT Prospective evaluation of the diagnostic accuracy of the novel ESC 2011 guidelines for rapid rule-out of NSTEMI using high sensitive cardiac troponin T. – B. Moehring, R. Twerenbold, K. Wildi, P. Haaf, T. Reichlin, N. Arenja, M. Wasila, T. Mosimann, M. Reiter, C. Mueller (Basel, CH) Usefulness of a 3-hour compared to a 6-hour blood sampling protocol using high-sensitivity cardiac troponin T for rule-out and rule-in of non-STEMI in an unselected emergency department population. – M. Biener, M. Mueller, M. Vafaie, T. Keller, S. Blankenberg, H.D. White, H.A. Katus, E. Giannitsis (Heidelberg and Hamburg, DE; Auckland, NZ) Who funds the evidence in the ESC guidelines: government or industry? Analysis of class I acute coronary syndrome recommendations from 2011. – P. Kohli, S.A. Murphy, C.P. Cannon (Boston, US) Role of active coronary vasoconstriction in patients with NSTEMI. – P. Capozza, G. Todiere, E. Orsini, F.L. Dini, M. Marzilli (Pisa, IT) Release kinetics of cardiac biomarkers in patients with acute myocardial infarction. – C. Liebetrau, H. Moellmann, S. Szardien, O. Doerr, C. Troidl, J. Hoffmann, D. Sedding, A. Rolf, C. Hamm, H. Nef (Bad Nauheim and Giessen, DE) Performance of high-sensitivity troponin T in the early diagnosis of non-ST-elevation myocardial infarction in elderly patients presenting to an emergency department. – P. Bahrmann, A. Bahrmann, M. Christ, T. Bertsch, C.C. Sieber (Nuremberg and Erlangen, DE) Direct comparison of absolute and relative changes in high-sensitive cardiac troponin I in the early diagnosis of AMI. – K.S. Wildi, R. Twerenbold, M. Reiter, B. Moehring, P. Haaf, T. Reichlin, T. Mosimann, S. Osswald, C. Mueller (Basel, CH) Cardiac magnetic resonance tissue characterization in the acute and chronic phase of reperfused Non-ST elevation myocardial infarction. – M. Mariyadas, T. Walcher, W. Rottbauer, P. Bernhardt (Ulm, DE) Changing patterns of in-hospital management of acute coronary syndromes in the United Kingdom 1998-2008. – G. Erdem, D. Babalis, W. Banya, J. Booth, F. Nugara, J. Colllinson, M. Flather (London and Norwich, GB) Complementary intravenous Enoxaparin during percutaneous coronary interventions and NSTE-ACS. Is it necessary? – E. Bosch Peligero, V. Serra Garcia, A. Alonso Tello, I. Otaegui Irurueta, N. Bellera Gotarda, E. Domingo Ribas, G. Marti Aguasca, C. Arredondo Flores, B. Garcia Del Blanco, D. Garcia-Dorado Garcia (Barcelona, ES) Early diagnosis of acute myocardial infarction in patients with kidney disease using more sensitive cardiac troponin assays. – R. Twerenbold, T. Reichlin, M. Reiter, P.H. Haaf, K. Wildi, M. Potocki, S. Osswald, C.H. Mueller (Basel, CH; Boston, US) Use of troponin testing in internal emergency medicine. – J. Searle, A. Slagman, J.O. Vollert, H. Storchmann, P. Oestereich, R. Muller, M. Koch, R. Somasundaram, M. Mockel (Berlin, DE; Townsville, AU) 292 P5054 P5055 P5056 P5057 P5058 P5059 P5060 P5061 P5062 P5063 P5064 P5065 TUESDAY, 28 AUGUST 2012 – AFTERNOON POSTERS Early strain echocardiography may exclude high-grade coronary artery stenosis in suspected non-ST-elevation acute coronary syndrome. – T. Dahlslett, B. Grenne, C. Eek, B. Sjoli, H. Skulstad, O.A. Smiseth, T. Edvardsen, H. Brunvand (Arendal and Oslo, NO) The diagnostic accuracy of novel biomarkers of myocardial injury in the unselected emergency room population. – P. Collinson, D. Gaze, P. Thokala, S. Goodacre (London and Sheffield, GB) Reduction of medical consumption in low risk chest pain patients. – A.E.C. Kingma, A.J. Six, B.E. Backus, M.J.M. Cramer, G.A. De Wit, A. Mosterd, P.J. Senden, T.P. Mast, P.A. Doevendans (Utrecht, Woerden and Amersfoort, NL) A significant proportion of patients with acute coronary occlusion lack ST elevation: implications for diagnosis and provision of primary angioplasty services. – A. Apps, A. Malhotra, O. Ali, R. Smith, R. Lane, T. Kabir, M. Mason, M. Whitbread, C. Ilsley, M. Dalby (London, GB) Mitral annular excursion in patients with suspected non-ST-elevation acute coronary syndrome can identify coronary occlusion and predict mortality. – W. Zahid, J. Johnson, C. Westholm, C. Eek, R. Skulstad, E. Fosse, R. Winter, T. Edvardsen (Oslo, NO; Stockholm, SE) Risk stratification in non-ST-elevation Acute Coronary Syndromes: utility of using both GRACE and CRUSADE models. – J. Ferreira Santos, S. Goncalves, P. Amador, F. Seixo (Setubal, PT) Rapid rule-out of NSTEMI by using a high sensitive prototype assay for troponin I: a prospective evaluation of the safety of the novel ESC 2011 guidelines. – B. Moehring, R. Twerenbold, K. Wildi, N. Arenja, T. Mosimann, C. Zellweger, T. Reichlin, M. Reiter, P. Haaf, C. Mueller (Basel, CH) The nature and clinical outcomes of total occlusion in non-ST elevation myocardial infarction; is it bad or good? – B.-H. Hwang, K.Y. Chang, K.B. Seung, Y.S. Koh, I.J. Choi, S.M. Lim, J.J. Kim, M.O. Chang, M.G. Kang, J.E. Lee (Seoul, KR) P5066 P5067 P5068 P5069 P5070 P5071 P5072 P5073 NEW INSIGHTS IN POST-MYOCARDIAL INFARCTION FOLLOW-UP P5074 P5075 P5076 P5077 P5078 P5079 P5080 TUESDAY – AFTERNOON One-year risk of stroke following acute myocardial infarction. – A. Ulvenstam, U. Kajermo, A. Modica, T. Mooe (Ostersund, SE) Improving quality of care in the elderly after acute myocardial infarction? The Myocardial Ischaemia National Audit Project (MINAP) 2004 - 2009. – C.P. Gale, A.D. Simms, B.A. Cattle, P.D. Baxter, D.R. Greenwood, J. Deanfield, I.R. Pearson, K.A.A. Fox, A.S. Hall, R.M. West (Leeds and Edinburgh, GB) The rs12526453 polymorphism in intron of the PHACTR1 gene is associated with 5-year mortality of patients with ST-elevation myocardial infarction. – A. Kozieradzka, W. Pepinski, E. Waszkiewicz, D. Maciorkowska, M. Olszewska, M. Skawronska, A. Niemcunowicz-Janica, S. Dobrzycki, W.J. Musial, K.A. Kaminski (Bialystok, PL) High 3-year-mortality rates in females with newly diagnosed diabetes after acute STEMI and NSTEMI in clinical practice in Germany: results of the Sweetheart-registry. – A.K. Gitt, F. Towae, E. Deeg, A. Papp, U. Zeymer, J. Senges, R. Zahn (Ludwigshafen, DE) The clinical significance of right ventricular dysfunction with or without pulmonary hypertension after acute myocardial infarction. – D. Aronson, K. Shahar, H. Hammerman, R. Dragu (Haifa, IL) One year outcome in HIV-infected patients with myocardial infarction. – G. Molins, J. Cottenet, M. Zeller, L. Lorgis, C. Touzery, H. Aube, Y. Cottin, C. Quantin (Dijon, FR) Accuracy of high-sensitive cardiac troponins for long-term mortality. – P. Haaf, K. Wildi, M. Reiter, C. Zellweger, R. Twerenbold, R. Hoeller, T. Reichlin, M. Rubini Gimenez, B. Moehring, C. Mueller (Basel, CH) Large differences between patients with acute myocardial infarction included in two Swedish health registers. – S. Aspberg, T. Kahan, M. Koster, U. Stenestrand (Stockholm and Linköping, SE) Non-ST-segment elevation acute coronary syndrome caused by the left main stem stenosis - impact of multivessel diseases on treatment strategy and 12-month. Analysis from the PL-ACS Registry. – M. Gierlotka, M. Gasior, M. Hawranek, M. Tajstra, P. Buszman, J. Kubica, A. Lekston, M. Zembala, G. Opolski, L. Polonski (Zabrze, Katowice, Bydgoszcz and Warsaw, PL) Improve in survival after myocardial infarction: the impact of a universal health care reform in a latin-american country. – C. Nazzal, F. Lanas (Santiago and Temuco, CL) Prognostic factors in chest pain patients: a quantitative analysis of the HEART score. – B.E. Backus, A.J. Six, P.A. Doevendans, J.C. Kelder, E.W. Steyerberg, Y. Vergouwe (Utrecht, Woerden, Nieuwegein and Rotterdam, NL) Occurrence of major bleeding during long-term follow up of unselected patients with STE vs NSTE Acute Coronary Syndromes. – F. Vagnarelli, G. Melandri, N. Taglieri, F. Semprini, L. Cinti, G. Norscini, P. Ortolani, S. Nanni, C. Rapezzi, A. Branzi (Bologna, IT) Persistence of high events rate following STE vs NSTE acute coronary syndrome in the contemporary era: 5-years outcome in a large real world registry. – F. Vagnarelli, G. Norscini, N. Taglieri, L. Cinti, F. Semprini, S. Nanni, P. Ortolani, C. Rapezzi, A. Branzi, G. Melandri (Bologna, IT) P5081 P5082 P5083 P5084 P5085 P5086 293 TUESDAY, 28 AUGUST 2012 – AFTERNOON POSTERS High rate of bleeding complications in a real-life Swedish population with ACS. – J. Alfredsson, S. Zolfagharian, A.C. Holm, E. Swahn (Linköping, SE) Impact of contrast-induced nephropathy on long-term cardiovascular events in acute coronary syndrome patients with Chronic Kidney Disease: results from icas registry. – H. Watabe, A. Sato, T. Hoshi, D. Abe, E. Ojima, Y. Kakefuda, T. Harunari, D. Hiraya, Y. Noguchi, K. Aonuma (Tsukuba and Tomobe, JP) Pathological Q-wave development in myocardial infarction in patients treated by primary percuteneous coronary intervention. – R. Delewi, G. Ijff, A. Hirsch, L. Robbers, R. Nijveldt, A.M. Van Der Laan, J.G.P. Tijssen, A.C. Van Rossum, F. Zijlstra, J.J. Piek (Amsterdam and Rotterdam, NL) Long-term prognosis estimation after acute coronary syndrome: is there a role for angiographic scores? – H. Dores, J. Ferreira, F.M. Costa, C. Aguiar, M. Trabulo, M.S. Carvalho, P.J. Sousa, P.A. Goncalves, M.S. Almeida, M. Mendes (Lisbon, PT) Bleeding complications in patients with acute myocardial infarction. A gender perspective. – A.C. Holm, E. Swahn, J. Alfredsson (Linköping, SE) Angiotensin receptor blockers as the first choice in patients with preserved left ventricular systolic function after acute myocardial infarction from the Korean Acute Myocardial Infarction registry. – J.H. Lee, J.K. Kang, S.Y. Jang, M.H. Bae, D.H. Yang, H.S. Park, Y. Cho, S.C. Chae, M.H. Jeong, Y.J. Kim (Daegu and Gwangju, KR) Prognostic implications of sleep duration in first months after ST-elevation myocardial infarction. – F.M. Szymanski, G. Karpinski, A. Hrynkiewicz-Szymanska, A. Platek, M. Grabowski, F. Majstrak, K.J. Filipiak, G. Opolski (Warsaw, PL) Copeptin predicts long-term mortality in patients with non-st-elevation myocardial infarction. – C. Liebetrau, O. Doerr, S. Szardien, C. Troidl, C. Horstmann, J. Rixe, D. Sedding, H. Moellmann, C. Hamm, H. Nef (Bad Nauheim and Giessen, DE) Predictive role of specific monocyte subsets for major adverse cardiac events after ST-elevation myocardial infarction. – A. Ghattas, G. Lip, H. Griffiths, E. Shantsila (Birmingham, GB) Prediction of late mortality after myocardial infarction by means of the GRACE Score in contemporarily treated patients. – P. Barthel, A. Mueller, K. Ulm, M. Malik, G. Schmidt (Munich, DE; London, GB) Clinical outcomes after percutaneous or surgical revascularization of unprotected left main coronary artery related myocardial infarction: a single-center experience. – M.J.D. Grundeken, M.M. Vis, M.A. Beijk, J.J. Kloek, J.J. Wykrzykowska, J.G.P. Tijssen, J.J. Piek, B.A.J.M. De Mol, J.P.S. Henriques, R.J. De Winter (Amsterdam, NL) Impact of gender on clinical profile and long-term prognosis in patients with early-onset myocardial infarction. – F. Notarangelo, L. Foco, F. Bontardelli, M. Tubaro, N. Marziliano, P.M. Mannucci, L. Bernardinelli, C. Caminiti, P.A. Merlini, D. Ardissino (Parma, Pavia, Rome and Milan, IT) Probable effects of obstructive sleep apnea on plaque vulnerability and progression of coronary atherosclerosis in patients with acute myocardial infarction. – H. Nakashima, T. Henmi, Y. Uchida, Y. Shiraisi, T. Nunohiro, K. Maemura (Nagasaki, JP) Prognostic impact of plasma aldosterone levels on long term outcome after myocardial infarction. – K. Inoue, T. Tanigaki, Y. Tsubakimoto, T. Sakatani, S. Kimura, A. Matsuo, H. Fujita, M. Kitamura (Kyoto, JP) Chest pain patients with false positive hs-TnT in emergency department have the same one year risk of MACE as those who were hospitalized for acute coronary syndromes. – M.T. Cardillo, L.M. Biasucci, M. Zaninotto, N. Gentiloni Silveri, G. Biasillo, M. Mion, G. Niccoli, M. Gustapane, M. Plebani, F. Crea (Rome and Padua, IT) Acute coronary syndromes in the elderly. – P.C. Amador, S. Goncalves, F. Seixo, J. Ferreira Santos (Setubal, PT) Baseline hypercalcaemia in acute coronary syndrome patients: a five-year outcome study. – I. Rangel, C. Sousa, A. Goncalves, A. Sousa, A.S. Correia, M. Paiva, V. Ribeiro, F. Melao, R. Lopes, M.J. Maciel (Porto, PT) Serum uric acid: a forgotten prognostic marker in acute coronary syndromes? – A.T. Timoteo, A. Lousinha, J. Labandeiro, J.A. Oliveira, M.L. Ferreira, R. Cruz Ferreira (Lisbon, PT) Prognostic role of flow mediated dilation in patients with no-ST-segment elevation acute coronary syndrome. – G. Careri, R. Nerla, A. Di Monaco, M. Milo, A. Di Franco, M. Laurito, G. Pinnacchio, G. Scalone, G.A. Lanza, F. Crea (Rome, IT) Predictive value of advanced glycation end products for the development of post-infarction heart failure. – S. Raposeiras Roubin, B. Rodino Kostka, B. Paradela Dobarro, L. Grigorian Shamagian, J.M. Garcia Acuna, P. Aguiar Souto, M. Jacquet Hervet, M.V. Reino Maceiras, E. Alvarez Castro, J.R. Gonzalez-Juanatey (Santiago de Compostela, ES) Mitral regurgitation in postmyocardial infarction patients. – V.A. Kuznetsov, E.I. Yaroslavskaya, G.S. Pushkarev, M.G. Shahova (Tyumen, RU) Risk stratification by killip class and left ventricular systolic function in patients with acute myocardial infarction in modern era from korean acute myocardial infarction registry. – J.H. Lee, J.K. Kang, S.Y. Jang, W.S. Choi, D.H. Yang, H.S. Park, Y. Cho, S.C. Chae, M.H. Jeong, Y.J. Kim (Daegu and Gwangju, KR) Early effects of ivabradine in combination with beta-blockers compared to beta-blockers uptitration on systolic and diastolic function, NT-proANP and exercise capacity in pts after Q-MI with EF<45%. – K. Amosova, I.U. Rudenko, I. Prudky, Y. Xu, A. Bezrodnyi (Kiev, UA) 294 P5087 P5088 P5089 P5090 P5091 P5092 P5093 P5094 P5095 P5096 P5097 P5098 P5099 P5100 P5101 P5102 P5103 P5104 P5105 P5106 P5107 P5108 P5109 TUESDAY, 28 AUGUST 2012 – AFTERNOON POSTERS Independent contribution of additional risk factors to GRACE score in after-discharge, long-term prognosis. – M. Grabowski, K.J. Filipiak, R. Glowczynska, G. Opolski (Warsaw, PL) Prognosis importance of absence of angina in non-ST elevation myocardial infarction. – J.Y. Takada, R.B. Ramos, S.D. Avakian, J.A.F. Ramires, A.P. Mansur (São Paulo, BR) Is female gender a real independent predictor of mortality after acute coronary syndrome? – A.T. Timoteo, J. Labandeiro, J.A. Oliveira, M.L. Ferreira, R. Cruz Ferreira (Lisbon, PT) Peak Systolic Velocity (PSV) using colour-coded Tissue Doppler Imaging (TDI) is a strong and independent predictor of outcome in acute coronary syndrome patients. – C. Westholm, J. Johnson, T. Jernberg, R. Winter (Stockholm, SE) P5110 P5111 P5112 P5113 PATHOPHYSIOLOGY – BASIC MECHANISMS AND ATRIAL FUNCTION P5114 P5115 P5116 P5117 P5118 P5119 P5120 P5121 P5122 P5123 P5124 P5125 TUESDAY – AFTERNOON Left atrial volume and dynamics in chronic kidney disease. – K. Kadappu, L. Hee, A. Aravindan, S.T. Spicer, G. Suryanarayanan, J.K. French, L. Thomas (Liverpool, Sydney, AU) Next generation sequencing approach for the diagnosis of heart disease patients using a panel of 72 genes. – D. Cantalapiedra, P. Chevalier, A. Forteza, L. Moreno, A. Jamsheer, M. Martinez-Atienza, V. Fernandez-Pedrosa, S. Zuniga-Trejos, M. Gil, S. Santillan (Paterna, Madrid, Pamplona and Granada, ES; Bron, FR; Poznan, PL) Relation between QRS duration and atrial synchronicity in systolic heart failure: a color tissue Doppler imaging study. – O. Turak, F. Ozcan, F. Basar, A. Isleyen, E. Sokmen, O. Tufekcioglu, K. Cagli, S. Aydogdu (Ankara, TR) Prediction of the development of atrial fibrillation in patients With chronic heart failure: a comparative study of atrial late potential, 6 minute-walk test and Seattle Heart Failure Model. – T. Yamada, T. Morita, Y. Furukawa, M. Kawasaki, T. Fujimoto, T. Kondo, K. Ozu, K. Sengoku, H. Yamamoto, M. Fukunami (Osaka, JP) Nicorandil improved electrical and structural remodeling and prevented ventricular tachyarrhythmias in a mouse model of desmin-related cardiomyopathy. – M. Hirose, A. Sanbe, N. Matsushita, E. Taira (Shiwa-gun Yahabacho, JP) Right atrial stretching does not inhibit fluid intake after myocardial infarction. – M. Roscani, A.C.M. Omoto, L. Zornoff, L.S. Matsubara, B.B. Matsubara, J.I.F. Gobbi (Botucatu, BR) Characterization of cyclophilin A in coxsackievirus B3-induced myocarditis. – P. Seizer, K. Klingel, M. Sauter, T. Schonberger, C. Ochmann, R. Kandolf, M. Gawaz, A.E. May (Tübingen, DE) Left ventricular diastolic and systolic and atrial dysfunction in patients with hypertension might be related to increased oxidative stress and inflammation-final results. – Z.S. Szelenyi, G. Szenasi, M. Kiss, Z. Prohaszka, A. Patocs, A. Fazakas, I. Karadi, A. Vereckei (Budapest, HU) Decreased left ventricular compliance but preserved left ventricular relaxation in a risk factor-based porcine model of heart failure with preserved ejection fraction (HFPEF). – M. Schwarzl, S. Seiler, P. Steendijk, B. Pieske, H. Post (Graz, AT; Leiden, NL) Olmesartan inhibits ventricular remodeling and arrhythmias in a mouse model of chronic heart failure. – N. Matsushita, M. Hirose, Y. Takeishi, H. Shimojo, T. Kashihara, T. Nakada, E. Taira, U. Mende, M. Yamada (Shiwa-gun Yahabacho, Fukushima and Matsumoto, JP; Providence, US) Pitavastatin ameliorates experimental autoimmune myocarditis by decreased Th1/Th17 cytokines in mice. – K. Tajiri, N. Shimojo, K. Aonuma (Tsukuba, JP) Enhancement of cardiac histone deacetylase 6 (HDAC6) activity protects against cardiac disease in alpha-B-crystallin arg120gly transgenic mouse. – A. Sanbe, T. Marunouchi, M. Hirose, S. Aoki, Y. Tada, K. Tanonaka, H. Nishigori, A. Tanoue (Shiwa-gun, Yahabacho, Hachioji and Tokyo, JP) Nicorandil protects cardiomyocytes against alpha-B-crystallin arg120Gly-induced apoptosis. – A. Sanbe, T. Marunouchi, M. Hirose, E. Koizumi, K. Tanonaka, H. Nishigori, A. Tanoue (Shiwa-gun, Yahabacho, Hachioji and Tokyo, JP) The mitochondrial translocator protein ligands, 4’-chlorodiazepam and TRO40303 protect cardiomyocytes against doxorubicin toxicity. – A. D’Anglemont de Tassigny, R. Assaly, S. Schaller, R. Pruss, A. Berdeaux, D. Morin (Créteil and Marseille, FR) Adrenomedullin, ghrelin and leptin as potential biomarkers of chronic heart failure: an experimental study. – B. Sax, E.M. Vegh, K.V. Nagy, A. Kosztin, T. Barany, V. Kekesi, B. Merkely (Budapest, HU) Study of vav3 ser298thr polymorphism in patients with heart failure. – J.A. Andres Llamas, C. Cieza Borrella, M.J. Ruiz Olgado, J.A. Perez Rivera, P. Pabon Osuna, C. Martin Luengo, R. Gonzalez Sarmiento (Salamanca, ES) Soluble vascular endothelial growth factor receptor-2, but not vascular endothelial growth factor, is decreased in sera from patients with left ventricular hypertrophy and systolic dysfunction. – H. Wada, S. Ura, M. Akao, N. Masunaga, M. Abe, M. Ishii, T. Unoki, G. Osakada, A. Shimatsu, K. Hasegawa (Kyoto, JP) Matrix metalloproteinase level can predict left ventricular remodeling and systolic dysfunction after myocardial infarction. – M. Abdelhamid, A. El Faramawy, H. Gabr, W. Ammar, F. Al Enezi (Cairo, EG) Activation of agonistic proteins for toll-like receptor 4 in patients with dilated cardiomyopathy. – A. Riad, J. Witte, M. Doerr, L.R. Herda, K. Weitmann, M. Busch, W. Hoffmann, S.B. Felix (Greifswald, DE) P5126 P5127 P5128 P5129 P5130 P5131 P5132 295 TUESDAY, 28 AUGUST 2012 – AFTERNOON POSTERS Oxidative stress, inflammation and low levels of apelin as risk factors of left ventricular hypertrophy in type 2 diabetics with renal disease. – A.P. Silva, P.S. Sousa, A.T.P. Pinho, C. Silva, N. Santos, A. Camacho, N. Tavares, F. Rato, I. Jesus, P. Neves (Faro, PT) Cardiomyocyte structural deterioration and metabolic response in human DCM hearts. – E. Czarnowska, L. Ziolkowska, M. Kaleta, M. Syczewska, W. Kawalec, E. Rejchman-Warmusz, R. Wojnicz (Warsaw and Zabrze, PL) Abrogation of S100B expression in S100A1 deficient mice improves survival post myocardial infarction. – J. Tsoporis, J.-F. Desjardins, S. Izhar, F. Mohammadzadeh, G. Proteau, J. Baudier, T.G. Parker (Toronto, CA; Grenoble, FR) Impact of the PPARGC1A Gly482Ser polymorphism on left ventricular structural and functional abnormalities in patients with cardiovascular risk factors. – W. Kosmala, M. Cielecka-Prynda, L. Laczmanski, A. Orda, B. Karolko, A. Mysiak, M. Przewlocka-Kosmala (Wroclaw, PL) The involvement of peripheral regulatory T cells on the acute decompensated heart failure in the patients with reduced EF. – N. Ishihara, T. Noma, Y. Ishihara, Y. Miyauchi, K. Tada, W. Takabatake, C. Ikegami, K. Murakami, K. Ohmori, M. Kohno (Kagawa, JP) Circulating myeloid dendritic cells and interleukin-6 are predictors of heart failure in dilated and ischemic cardiomyopathy. – R. Pistulli, N. Hammer, D. Kretzschmar, I. Rohm, K. Schubert, M. Lichtenauer, H.R. Figulla, A. Yilmaz (Jena, DE) The bone morphogenic protein-antagonist Gremlin-1 serves as a new biomarker for structural heart disease and predicts clinical outcome. – K.A.L. Mueller, C.S. Zuern, U. Kramer, R. Kandolf, M. Gawaz, I.I. Mueller (Tübingen, DE) P5133 P5134 P5135 P5136 P5137 P5138 P5139 PREDICTORS FOR OUTCOME Lung ultrasound for the evaluation of pulmonary congestion in a pre-transplantation heart failure outpatient clinic: comparison with natriuretic peptides. – M.H. Miglioranza, L. Gargani, R.T. Sant’anna, M. Rover, A. Mantovani, C.J. Feldman, R.A. Kalil, R. Sicari, T.L. Leiria (Porto Alegre, BR; Pisa, IT) Depressed midwall fractional shortening is a powerful prognostic determinant in cardiac AL amylodosis. – S. Perlini, F. Salinaro, F. Musca, R. Mussinelli, M. Boldrini, A. Raimondi, A. Alogna, P. Pesce, G. Merlini, C. Rapezzi (Pavia, Milan and Bologna, IT) The electrocardiographic/echocardiographic mass ratio in the diagnosis of cardiac amyloidosis. – S. Perlini, F. Salinaro, F. Musca, R. Mussinelli, M. Boldrini, A. Alogna, C. Quarta, G. Palladini, G. Merlini, C. Rapezzi (Pavia, Milan and Bologna, IT) Evidence of subclinical perimyocardial involvement in patients with systemic lupus erythematosus: late gadolinium enhancement study. – A. Pastor, P. Choong, Z. Smith, B. Butzbach, R. Botnar, D. D’Cruz, E. Nagel, V. Puntmann (London, GB) Cardiac myosin binding protein C gene polymorphisms and diastolic heart failure. – C. Wu, J. Lee, C. Tsai, F. Chiang (Taipei and New Taipei City, TW) Subclinical abnormalities of the arterial tree and left ventricular myocardial deformation, relaxation and twist in chronic kidney disease. – V. Panoulas, S. Sulemane, A. Bratsas, P. Nihoyannopoulos (London, GB) Peak cardiac power output: a new hemodynamic tool to aid the diagnosis of heart failure with pre-served ejection fraction? A pilot study. – W. Dinh, W. Nickl, M. Coll Barroso, F. Kramer, T. Krahn, M. Doerner, R.M. Klein, C. Heming, B. Bjarnason-Wehrens, M. Seyfarth (Wuppertal, Düsseldorf and Cologne, DE) Relationship of pro-collagen biomarkers of myocardial fibrosis with myocardial dysfunction and metabolic derangement in type 2 diabetes. – C. Jellis, J. Sacre, C. Jenkins, B. Haluska, J. Martin, T. Marwick (Brisbane, AU; Cleveland, US) Acute improvement of left atrial mechanics and left ventricular diastolic function after Transcatheter Aortic Valve Implantation. – S. Spethmann, H. Dreger, G. Baldenhofer, K. Stueer, D. Saghabalyan, V. Stangl, M. Laule, G. Baumann, K. Stangl, F. Knebel (Berlin, DE) Diagnostic value of pulsatile hemodynamics for heart failure with normal ejection fraction. – T. Weber, S. Wassertheurer, M.F. Orourke, R. Zweiker, B. Hametner, A. Haiden, B. Eber (Wels, Vienna and Graz, AT; Sydney, AU) Perhexiline corrects energy deficiency and improves symptoms in chronic heart failure. – R.M. Beadle, L.K. Williams, M. Kuehl, S. Bowater, K. Abozguia, K. Patel, Z. Yousef, F. Leyva-Leon, M.P. Frenneaux (Aberdeen, Birmingham and Cardiff, GB; Toronto, CA) Index of lectin-like oxidized low-density-lipoprotein receptor is independently associated with left ventricular systolic dysfunction. – H. Wada, N. Masunaga, S. Ura, M. Akao, M. Abe, Y. Fujita, Y. Satoh, A. Shimatsu, T. Sawamura, K. Hasegawa (Kyoto and Osaka, JP) Levosimendan improves contractility in post ischemic myocardium in patients with acutely revascularised infarction complicated by decompensated heart failure. – T. Husebye, J. Eritsland, H. Arnesen, I. Seljeflot, L. Sandvik, A. Mangschau, R. Bjornerheim, G.O. Andersen (Oslo, NO) 296 P5140 P5141 P5142 P5143 P5144 P5145 P5146 P5147 P5148 P5149 P5150 P5151 P5152 TUESDAY, 28 AUGUST 2012 – AFTERNOON POSTERS P5153 P5154 P5155 P5156 P5157 P5158 P5159 P5160 P5161 P5162 P5163 P5164 P5165 P5166 P5167 P5168 TUESDAY – AFTERNOON The effect of aldosterone-antagonist therapy on aortic elastic properties in patients with moderate heart failure. – E. Vizzardi, A. D’Aloia, P. Della Pina, C. Lombardi, I. Bonadei, R. Rovetta, F. Quinzani, B. Piovanelli, M. Metra, L. Dei Cas (Brescia, IT) The treatment in patients with chronic heart failure with erythropoietin failure. – K. Zahidova (Baku, AZ) Acute heart failure patients with high initial blood pressure shows paradoxical hemoconcentrateion on admission. – M. Konishi, K. Kimura, T. Ebina, K. Hibi, K. Tsukahara, M. Endo, N. Iwahashi, N. Maejima, K. Saka, S. Umemura (Yokohama, JP) Myocardial and vascular dysfunction in young subjects, are related to dyslipidaemia and abdominal obesity but not to glycaemia. – Y.K. Kyaw, A.W. Roberts, L.M. Evans, A.G. Fraser (Cardiff, GB) Which adjunctive test to clinical evaluation is better to diagnose pulmonary congestion in a pre-transplantation heart failure outpatient clinic? – M.H. Miglioranza, R.T. Sant’anna, M. Rover, A. Mantovani, J.C. Haertel, P.A. Salgado Filho, A. Moraes, C.J. Feldman, R.A. Kalil, T.L. Leiria (Porto Alegre, BR) Sonographic pulmonary comet sign in diagnosis and monitoring of pulmonary congestion in HF. – M. Tsverava, D. Tsverava (Tbilisi, GE) Circadian variation of the occurrence of acute heart failure syndromes contributes to long-term prognosis in patients with non-ischemic cardiomyopathy. – H. Yasui, T. Hiroyuki, A. Funada, M. Amaki, T. Ohara, T. Hasegawa, M. Asakura, H. Kanzaki, T. Anzai, M. Kitakaze (Suita, JP) Correlations between hemodynamic parameters and serum high sensitive troponin-T. – S. Koyama, Y. Sato, Y. Takahashi, T. Sawa, Y. Tanada, H. Fujiwara, Y. Takatsu (Amagasaki, JP) A New Radiological Score for the verification of evolving pulmonary congestion-edema in the course of Acute Myocardial Infarction. – M. Shochat, M. Shotan, A. Asif, M. Kazatsker, Y. Levy, E. Noiman, I. Shochat, I. Dahan, D. Blondheim, S. Meisel (Hadera, IL) Predictors of augmented peripheral chemosensitivity in patients with systolic heart failure. – P. Niewinski, Z.J. Engelman, M. Fudim, S. Tubek, E.A. Jankowska, W. Banasiak, P. Ponikowski (Wroclaw, PL; Auckland, NZ; Düsseldorf, DE) BNP is higher in OptiVol alert with intrathoracic impedance than at baseline: from MOMOTARO study. – Y. Okamoto, S. Fujii, N. Nishii, A. Watanabe, S. Hiramatsu, K. Miyaji, Y. Tsushima, K. Kazushige, K. Mitsudo, H. Ito (Okayama and Fukuyama, JP) A classical clinical signs revised in 2012: echocardiographic assessment of jugular vein. A report from SICA-HF study. – P. Pellicori, J. Warden, A. Bennett, T. Mabote, S. Smith, E. Wright, P. Costanzo, A.L. Clark, J.G.F. Cleland (Hull, GB) Artificial neural network in early identification of heart failure progression in patients with telemonitoring management of chronic heart failure. – T. Heinze, A. Polze, M. Von Lowis, C. Sprenger, M. Oeff (Potsdam and Brandenburg an der Havel, DE) Abnormal acetylcholine - induced vasoreactivity in Takotsubo cardiomyopathy, novel pathophysiology insights onTakotsubo cardiomyopathy. – G. Crimi, M. Previtali, D. Bartolini, A. Iannone, S. Bellotti, A. Valbusa, P. Rubartelli (Genoa-Sampierdarena, Pavia and Genoa, IT) Heart failure symptoms and sleep-disordered breathing in patients with chronic heart failure - results from the SchlaHF-registry. – O. Oldenburg, M. Arzt, E. Erdmann, H. Teschler, A. Graml, K. Wegscheider, H. Woehrle (Bad Oeynhausen, Regensburg, Cologne, Essen, Martinsried, Hamburg and Blaubeuren, DE) Heart rate control is important even in heart failure patients -an interim analysis of the CHART-2 study-. – M. Miura, N. Shiba, J. Takahashi, K. Nochioka, T. Takada, H. Shimokawa (Sendai and Nasushiobara, JP) Incident heart failure with preserved ejection fraction in the general population. – F.P.J. Brouwers, R.A. De Boer, P. Van Der Harst, R.T. Gansevoort, S.J.L. Bakker, H.L. Hillege, D.J. Van Veldhuisen, W.H. Van Gilst (Groningen, NL) P5169 297 NOTES 298
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