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ANVESHANA
Research Article
AYURVEDA MEDICAL JOURNAL
OPEN LABEL SINGLE ARM PILOT STUDY ON THE EFFICACY OF
INDIGENOUS AYURVEDIC COMPOUND DRUGS IN THE
MANAGEMENT OF DIABETES MELLITUS
Mruthyunjaya Swamy
Anitha M. Swamy
Chief Consultants, Shathayu Wellness Centre, Ganganagar, Bengaluru, India
Corresponding email: [email protected]
ABSTRACT
Diabetes Mellitus is the most common and highly prevalent non-communicable lifestyle
disorder till date. Impaired glucose tolerance is a precursor to development of Hyperglycemia in
diabetes. Tackling this disease is a huge task today in front of all the streams of medical
sciences. In this regard an observational pilot study was conducted with Ayurvedic
Formulations. The study aimed at the variation in fasting blood sugar (FBS) and post prandial
blood sugar (PPBS) variations during the 3 course of medication. The changes were observed
and are reported. The study gave an appreciable reduction in the parameters and created a ray
of hope in the management of Diabetes mellitus through Ayurveda.
Key words: Diabetes mellitus, FBS, PPBS, Ayurvedic formulations
INTRODUCTION
Diabetes Mellitus is the most
common and highly prevalent noncommunicable lifestyle disorder till date.
Impaired glucose tolerance is a precursor to
development of Hyperglycemia in diabetes1.
Ayurveda is becoming a ray of hope to the
patients of Diabetes mellitus. The
explanations available in Ayurvedic texts are
highlighting the combined efficacy of
conservative and lifestyle management
measures. Due to its increased incidence, it
has become a burning challenge to all
Ayurvedic Practitioners to find an effective
solution resulting in the management of
disease.
Bengaluru (capital city of Karnataka,
India) is a fast growing high-tech city. The
working pattern, stressful life and
unhealthy, irregular food habits has
influenced the population to become the
victims of Diabetes mellitus.
This was the motivation to conduct a
research work on Diabetes mellitus and provide a promising Ayurvedic health care
facility to the stipulated population of Bengaluru.
In this regard a pilot study was taken
up on Diabetes mellitus in Shathayu Ayurveda Wellness centres affiliated to
Shathayu Foundation (R), Bengaluru.
Medicines explained in various
contexts of Ayurvedic literature were
selected and a compound preparation was
formulated for the treatment of Diabetes
Mellitus. Tab CP map, Tab Diacid and Tab
Hepafit were the formulations selected with
traditional practice basis.
Mruthyunjaya and Anitha: Efficacy of Indigenous Ayurvedic Compound Drugs in the Management of Diabetes Mellitus
The etiology of diabetes in India is
multi-factorial and includes genetic factors
coupled with environmental influences such
as obesity associated with rising living
standards, steady urban migration, and
lifestyle changes. Ayurveda is an ancient
science of India proved its efficacy in giving
a positive benefit to the Diabetic patients.
AIMS AND OBJECTIVES
 To treat the early diagnosed cases of
Diabetes Mellitus
 To assess the Hypoglycaemic effect of
Indigenous Ayurvedic Compounds
 Observing the incidence of risk factors
and complications of Diabetes mellitus
METHODOLOGY
The present trial was an Open Label
Single arm pilot study consisting of 100 (one
hundred) patients who fulfil the diagnostic,
Inclusion and Exclusion criteria.
Patients were included irrespective of
sex, occupation, religion and socio
economical status. Patient’s age group was
ranging from 25yrs to 70yrs. Raised blood
Sugar level was the only parameter to
include in the study.
Interventions:
 Tab. C.P. Map: Chandraprabha gulika &
Gokshuradi guggulu2
 Tab. Diacid: Gymnema sylvester leaf and
root, Eugenia jambolana seed, Emblica
officinalis fruit, Curcuma longa dried rhizome,
Casearia esculenta root, Enicostemma littorale
herb, Asphaltum.
 Tab. Hepafit (Each one tab BD)
Phyllanthus niruri, Tinospora cordifolia,
Azadirachta indica, Boerrhaavia diffusa, Eclipta
alba, Picrirhiza kurroa, Andrographis paniculata.
 Organic Wheat Grass Powder
The total duration of treatment was 3
months. All the patients were followed up
AAMJ / Vol. 1 / Issue 1 / Jan – Feb 2015
for a period of 6 months to observe the
complications.
Assessment Criteria: The Hypoglycaemic
effect was assessed only with FBS and PPBS
levels.
OBSERVATIONS AND RESULTS
Table 1: Showing Age wise distribution of patients
Age
20 - 30
31 - 40
41 - 50
51 - 60
61 - 70
71 - 80
No. of patients
04
17
31
30
17
01
Table 2: Showing sex wise distribution of patients
Sex
Male
Female
No. of patients
66
34
Table 3: Showing Marital status of patients
Marital status
Married
Unmarried
No. of patients
97
03
Table 4: Showing occupational status of patients
Occupation
Govt employee
Business
Housewife
Retired employee
Agriculture/Farmer
Employee
Engineer
Retired
Social Service
Self employee
Working
No. of patients
8
22
30
1
2
26
1
6
1
2
1
The obtained Data of the FBS and
PPBS were observed before and after treatment. So this is a preliminary observation
done in the Blood – Sugar variation of the
patient during the medication. As the study
was a pilot study based on a single criteria,
22
Mruthyunjaya and Anitha: Efficacy of Indigenous Ayurvedic Compound Drugs in the Management of Diabetes Mellitus
restricted to prove with suitable tests of
significance.
When the observational data was
analysed and interpreted along with the
laboratory Findings of FBS and PPBS there
was a marked improvement in the symptoms of Diabetes mellitus.
Table 5: Showing BT and AT difference in FBS
Particulars
n
Mean
Median
Standard error of
mean
Standard
deviation
Before
Treatment
100
165.0
152.5
After
treatment
100
130.8
120.5
5.161
4.260
51.61
42.60
Table 6: Showing BT and AT difference in PPBS
Particulars
n
Mean
Median
Standard error of
mean
Standard
deviation
Before
Treatment
100
239.0
225.5
After
treatment
100
189.9
168.0
7.364
6.373
73.64
63.73
DISCUSSION & CONCLUSION
Diabetes mellitus is occupying the
major Indian population as a lifestyle disorder. In the Present study the disease was
more prevalent in 4th and 5th decade of life
i.e. 31 & 30 patients included in the study
AAMJ / Vol. 1 / Issue 1 / Jan – Feb 2015
were of 41-50 and 51-60 age groups
respectively. The distributions of patients
were more in Housewives and working
class. This denotes that the disease is more
prone to the working population of the
country.
The poly herbal drugs included
formulations were having their action over
Hyperglycemia. Mean difference of FBS and
PPBS were appreciable in the trial. In this
study we could appreciate only the Hypoglycemic effect. This observation has initiated
to conduct a standard clinical trial with all
established parameters of Diabetes mellitus
with suitable Research protocols.
The study showed a significant hypoglycaemic effect in Diabetic patients.
Conservative management of disease along
with the life style modifications became the
heart of this study. This successful Pilot
Study has laid a milestone to take up this
study in a large scale by fulfilling all the research protocols.
REFERENCES
1. Exploring the Research on Diabetes
Mellitus: Status of Current Evidence
from a 40-year Quantitative Trend
Analysis
of
Published
Articles:
http://www.scopemed.org/?mno=38932.
2. Shri Govind Das – Bhaishajya ratnavali;
edited by Bhishagratna Brahma Shankar
Mishra:
Choukamba
Prakashan,
Varanasi; pp.321; pp.1312
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