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Biology
Name:__________________________________
DNA Structure and Replication Quiz Review Sheet
Fill-in the Blanks:
Use the following word list to answer the following questions. Not every word is used, but you should be
familiar with them all for your quiz.
Double Helix
Cytosine
Nitrogen Base
S Phase of Interphase
Thymine
Nucleotides
Crick
DNA Polymerase
Semiconservative
Guanine
Watson
DNA Replication
Covalent Bonds
Phosphate Group
Nucleic Acids
Adenine
Chargaff
Deoxyribose Sugar
Helicase
Hydrogen Bonds
Mitosis
Antiparallel
Replication Fork
1. Chargaff’s Rule says that thymine is equal in amount to ___________________ and cytosine is equal
in amount to ___________________ in a double stranded DNA molecule.
2. DNA is made of made of subunits or building blocks called ________________________.
3. During _____________________, DNA makes an exact copy of itself. This occurs during
______________________________ of the cell cycle.
4. The two scientists credited with determining the DNA structure are _____________________ and
__________________________.
5. The shape of a DNA molecule is a _______________________________ with the two strands of DNA
running _____________________ or opposite each other.
6. The two subunits that make up the backbone of the DNA molecule are _________________________
and _____________________. They are joined together with ___________________ bonds.
7. The rungs of the DNA molecule are made of four different kinds of ____________________________.
They are held together by ______________________ bonds.
8. ______________________ is the enzyme that unwinds and unzips the DNA molecule during
replication.
9. A _____________________________ is made when the DNA strands are pulled apart
10. _______________________ is the enzyme that builds the complementary strands of DNA during
replication.
11. DNA replication is said to be a _______________________ process because each of the original
strands serves as templates for building the new strands.
12. Replication is required for _________________ to occur in the cell, because DNA copies are divided
between cells.
13. DNA and RNA are examples of ____________________________.
13. On the lines below, write the strand of DNA nucleotides that would be opposite the following pieces
of DNA.
5’ A T G C C A G C T A G G A T C 3’
5’ T C G A T T A G C G A T C C G 3’
_____________________________
____________________________
14. The nitrogen bases in a double stranded DNA molecule are made of 15% adenine. What percent are
each of the following bases?
___________ Guanine
__________ Cytosine
___________Thymine
15. What does DNA stand for? _______________________________________________________
16. Color the following parts of the nucleotides. Use the box next to them as a key for which
color represents which part of the nucleotide.
Deoxyribose Sugar (Labeled D)
Thymine
Phosphate Group (Labeled P)
Cytosine
Adenine
Guanine
17. Why is it significant that the paired nitrogen bases are held together by hydrogen bonds, while the
sugars and phosphate groups in the backbone are held together by covalent bonds?
18. On the diagram below of DNA replication, draw in the enzymes Helicase and DNA Polymerase. You
may also color the image to help review DNA structure.