The Mount Sinai Postdoc Periodical Monthly newsletter, April 2015 In this issue: Page 1: MountHSinaiHPostdocHFitness6HTheHYpassHandH”eyond ”yH4elaineHLeholski Recently.H emailsH haveH beenH sentH requestingH theH inputH ofH postdocsH onH theirH fitnessH centerH useH andH howH effectiveHtheHfreeHpassesHareHtoHtheH5xY-HTheHreasonHforHthisHisHtoHhopefullyHbringHaboutHsomeHpositiveHchangeH ScientistsmrecommendmbanmonmCRISPRE forHSinaiHpostdocsHbyHprovidingHsomeHnewHfitnessHoptionsHandHopportunitiesHtoHkeepHusHhappyHandHhealthy-H Lurrently.HthereHareHfreeHdailyHpassesHqcalledHtheHY’passfHavailableHtoHallHpostdocsHatHMountHSinaiHthroughHtheH Cas9mgenomemeditingminmhumans GraduateH StudentH HelpdeskH website-H OnceH registeredH onH theH site.H postdocsH canH obtainH upH toH (H passesH perH weekH butH canH onlyH signH upH oneH weekH inH advance-H TheH numberH ofH Y’passesH wasH increasedH asH ofH MarchH W.H 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withH dailyH fitnessHclasses-HNYUHandHLolumbiaHofferHdiscountedHratesHtoHtheirHfitnessHfacilitiesHforHpostdocsHq,W3(HandH,(OOH perH year.H respectivelyf-H LornellH offersH dailyH passesH forH ,!H toH “sphaltH GreenH onH 5WH StreetH andH YorkH “venue-H PostdocmPeriodicalmCrosswordmPuzzle:m WhileHMountHSinaiHdoesHofferHweeklyHyogaHclassesHqThursdaysHatH!6(OpmfHandHaHwalkingHgroupHqWednesdaysH Sciencem101 atHnoonf.HthereHaren’tHfitnessHfacilitiesHavailableHforHemployeesHorHpostdocsHtoHuseHonHaHregularHbasis-H MountmSinaimPostdocmFitness:mThem YpassmandmBeyond Page 2: Page 3: SoHlet’sHtalkHaboutHtheHfuture-HItHseemsHclearHthatHtheHY’passHsystemHisn’tHworking-HThereHareHtooHfewHY’ passesHforHtooHmanyHpostdocs.HandHtheHfinancialHburdenHofHpayingHforHmoreHY’passesHisHjustHtooHhigh-H TheH PostdoctoralH OfficeH atH MountH SinaiH paysH forH theseH Y’passesH butH theH moneyH couldH beH potentiallyH investedH intoH providingH on’siteH fitnessH facilitiesH forH allH postdocsH andH employees-H WithH ourH closeH proximityH toH LentralH Park.H evenH showerjchangeH roomH facilitiesH wouldH beH aH greatH benefitH forH allH SinaiH employees-HIt’sHbeenHwell’documentedHthatHfitHemployeesHgetHsickHlessHoften.HhaveHmoreHenergy.HareH lessH stressedH andH areH moreH positiveH atH work-H 8ncouragingH fitnessH hasH widespreadH resultsH forH theH employer.HincludingHfewerHlostHorHmodifiedHworkingHdaysHandHlowerHemployeeHturnoverHqseeHthisHarticleH fromH theH HarvardH ”usinessH Reviewf-H RightH now.H theH PostdocH 8xecutiveH LommitteeH isH workingH withH TheresaHScarabinoHfromHtheHPostdoctoralHOfficeHtoHfindHoutHwhatHwouldHbenefitHtheHpostdocHcommunityH atHSinaiHandHwhatHcanHbeHdoneHtoHachieveHit-HWeHwillHcontinueHtoHprovideHupdatesHthroughHemailHandH theHPostdocHPeriodicalHsoHkeepHcheckingHbackl www-vailfittoride-com ScientistsHRecommendH”anHonHLRISPRjLas5HGenomeH8ditingHinHHumansH ”yHLeciliaHSedano LlusteredHregularlyHinterspacedHshortHpalindromicHrepeatsHqLRISPRfHandHLRISPR’associatedHqLasfHsystemsHareHrevolutionizingHtheHfieldHofHgenomeH editingH dueH toH theirH broadH applicationsH inH geneH therapy.H stemH cellH engineering.H animalH modelH creation.H andH theirH greatH potentialH forH “precisionH medicine”-HTheHlowHcostHandHamenabilityHofHtheseHsystemsHtoHintroduceHorHcorrectH4N“HsequencesHinHaHvarietyHofHorganismsHcanHalsoHbeHseenHasHaH double’edgedHsword-HThus.HourHnewHabilityHtoHuseHtheseHtoolsHtoHcontrolHhumanHheredityHraisesHimportantHglobalHbioethicalHconcerns“HgroupHofHU-S-HscientistsHandHexpertsHinHlawHandHbioethicsHrecentlyH metH inH Napa.H Lalifornia.H toH haveH anH openH discussionH onH theH usesH andHimplicationsHofHthisHnewHtechnology-HLastHmonthHtheyHpublishedH inH ScienceWH aH listH ofH recommendationsH forH theH futureH ofH genomeH editingH andH calledH forH aH temporaryH moratoriumH onH itsH useH inH humans-H ThoughH tightlyH regulatedH inH theH U-S-H butH notH inH otherH countriesH aroundH theH world.H theyH concludeH andH indicateH thatH thisH technologyHisHnotHreadyHforHclinicalHuse-HTheHconcernHbeingHthatHitsH safetyH hasH notH beenH assessed.H andH regulationsH andH guidelinesH haveH notH yetH beenH established-H TopicsH forH discussionH rangeH fromH howHmuchHLRISPRHoff’targetingHcanHbeHallowedHinHaHclinicalHsettingH toH howH muchH theH humanH genomeH shouldH beH altered-H TheseH willH needH toH beH addressedH byH bothH theH scientificH communityH andH governmentH organizationsH beforeH attemptingH germlineH genomeH modificationHinHtheHclinic-HOnHtheHotherHhand.HtheHNapaHgroupHmadeH clearHtheirHsupportHforHtheHuseHofHthisHnewHtechnologyHinHtransparentH basicHresearchHwithHhumanHcells.HasHlongHasHtheyHdon’tHimpactHtheH www-medicalnewstoday-com germlineThisHrecentHpublicationHhasHgatheredHsupportHfromHdifferentHresearchHentitiesHaroundHtheHcountryHandHtheHworld-HTheHfactHthatHgenomeHengineeringH techniquesHhaveHtheHexceptionalHpotentialHforHeditingHnon’humanHandHhumanHorganismsHmakesHitHaHworld’HandHlife’changingHtechnology.HwhileHalsoH raisingH importantH scientificH andH moralH questions-H NewH platformsH forH theseH discussionsH areH necessary.H callingH forH allH scientistsH aroundH theH worldH toH continueHresearchingHtheHtherapeuticHforceHthatHisHtheHLRISPR’LasHsystem.HwhileHalsoHadheringHtoHmoralHandHethicalHprinciplesW- H”altimoreH4-HetHal-H“HprudentHpathHforwardHforHgenomicHengineeringHandHgermlineHgeneHmodification-HScienceH()0.H(3’(0-HqxOW!f-H4OI6HWO-WWx3jscience-aabWOx0 ThemMountmSinaimPostdocmPeriodicalvmAprilm2015 Pagem1 New hope in the war on bacteria ?y!Yatie!Nolan! *ntibiotic!drug!resistance!has!been!steadily!growing!more!prevalent!and! more! deadly! in! the! last! few! years)! Whether! through! overuse! or! the! resilience!of!these!“bugs”!this!resistance!is!something!that!Sir!*lexander! 5leming! probably! never! imagined! when! he! stumbled! across! the! world’s! first!antibiotic)!!5lemingE!who!hailed!from!ScotlandE!discovered!the!world! first! antibioticE! penicillinE! by! accident)! Le! left! plates! streaked! with! staphylococci! on! a! bench! while! taking! a! holiday! ,something! scientists! aren’t! very! used! toI! and! discovered! the! penicillin! mold! Penicillium! Notatum! in! W”N“)! ! Where! the! mold! had! grown! the! staphylococci! had! died)! This! accidental! eureka! moment! was! to! change! the! course! of! medicine!forever)! Previously!diseases!and!injuries!that!would!have!killed!people!were!now! treatable!and!curable)!6n!the!last!decade!a!very!real!threat!has!developed! in! the! form! of! antibiotic! resistance! which! is! seeing! previously! benignE! treatable! infections! causing! severe! illness! and! death! once! again)! *ntibiotic! resistance! occurs! when! bacteria! develop! resistance! to! therapeutic!levels!of!antibiotics)!?acteria!can!become!resistant!in!one!of! two!ways’!by!genetic!mutation!that!allows!resistance!or!by!acquiring!the! resistance!from!another!bacterium)!*ntibiotic!resistance!has!been!further! aided! due! to! the! easy! accessibility! and! over! prescribing! of! antibioticsE! even!for!viral!infections!for!which!they!are!ineffective)! Teixobactin! is! a! new! antibiotic! promising! to! help! overcome! the! scourge! of! antibiotic! resistance)! Teixobactin! was! identified! through! screening! of! uncultured!bacteriaK!found!in!soil!and!isolated!using!a!novel!multichannel! chip!isolation!system)!Teixobactin!was!isolated!from!7leftheria!terrae!and! functions! by! binding! to! bacterial! cell! wall! precursor! components! thus! preventing! the! bacteria! from! reproducing)! 6t! has! shown! strong! activity! against! gram(positive! superbugs! such! as! 'RS*E! 3lostridium! difficileE! tuberculosis! and! has! bactericidal! action! against! vancomycin(resistant! Staphylococcus!aureus!which!makes!Teixobactin!particularly!important!in! the! fight! against! hospital(acquired! infections)! ! While! this! antibiotic! has! given!new!hopeE!it!is!currently!only!at!the!animal!trial!stage!and!may!take! time! to! get! to! market)! 6f! it! does! come! through! clinical! trialsE! will! it! be! squandered!and!abused!like!the!drugs!that!came!before!it:!Perhaps!our! plan!should!be!two(fold’!a!new!avenue!for!treatment!and!an!entirely!new! paradigm!that!aims!to!prevent!fast!emerging!resistance)! KUncultured’!bacteria!that!do!not!grow!under!laboratory!conditions News and upcoming events ?y!0rs)!'erina!Varghese!and!Ryan!3ummings Jreetings!fellow!postdocsE 6!am!very!excited!to!take!over!from!Yami!as!the!new!3o(chair!for!the! Postdoc!7xecutive!3ommittee!,P73IF!!6!certainly!have!big!shoes!to!fill! but!togetherE!with!your!helpE!6!feel!that!we!can!make!a!positive!impact! on!the!postdoc!way!of!life!here!at!'ount!Sinai!both!now!and!for!future! trainees) One!way!to!make! a!lasting!change!to!keep!science!funded! is!to!roll! up!your!sleeves!and!take!on!science!policy!in!the!political!arenaF!!This! past!monthE!6!had!the!opportunity!to!do!so!in!WashingtonE!03!as!an! *merican! *ssociation! of! 6mmunologists! ,**6I! Public! Policy! 5ellow! and!it!was!a!tremendous!experience)!!0uring!the!year(long!fellowshipE! we!learned!how!bills!are!passed!and!funds!are!distributed!for!science! research!and!education)!!We!also!assessed!the!National!6nstitutes!of! Lealth!,N6LI!funding!situation!and!even!met!with!both!the!leaders!of! National! 6nstitute! of! *llergy! and! 6nfectious! 0isease! ,N6*60I! and! members! of! the! US! 3ongressF! ! OverallE! the! goal! for! our! 3apital! Lill! 0ay! visit! was! to! advocateSencourage! members! of! 3ongress! to! provide!predictable!and!sustainable!funding!for!the!N6L!to!ensure!that! weE!as!scientistsE!can!continue!to!unravel!the!mechanisms!of!disease! that!will!ultimately!lead!us!towards!pathways!for!cures)! Regardless!of!nationality!or!political!party!affiliationE!6!encourage!all!of! you! to! develop! a! basic! understanding! of! science! policy! and! an! outward!appreciation!for!science!advocacy)!!The!more!we!discuss!our! work!within!the!local!communityE!the!greater!impact!we!will!have!with! our!representatives!and!their!push!to!increase!N6L!funding)!! *lsoE! like! **6E! other! professional! organizations! offer! public! policy! fellowships!which!are!a!great!way!to!get!into!science!policy!and!build! your! 3V! if! you! are! interested! in! exploring! this! career! path)5inallyE! 6! have! laid! the! ground! work! for! a! formal! 'ount! Sinai! Science! Policy! Jroup!where!we!can!cover!a!wide!range!of!topics!relating!to!science! and! politics)! ! We! are! currently! affiliated! with! the! National! Science! Policy! Jroup! however! our! group! is! only! in! its! fledgling! stage! and! could! use! your! helpF! ! 6f! interestedE! please! contact! me! at! ryan)cummingsqmssm)edu)!Jood!luck!with!your!researchF Ryan Thanks! to! everyone! who! came! out! for! the! 'arch! monthly! postdoc!social)!The!next!social!will! be!on!*pril! NUth! (! there! will! be! food! and! beverages! as! usual! so! come!on!outF!There!will!also!be!coffee!for!those!of!you! who! need! a! 5riday! pick! me! up! before! continuing! with! your!night!out!on!the!town!or!returning!to!lab) http’SSwww)forbes)comSsitesS judystoneSNOW/SOWSO“Steixobactin(and(ichip( promise(hope(against(antibiotic(resistanceS Hundreds of Cherry blossoms and orchids are waiting for you at the NYC botanical gardens by!$esica!Qevingston!'ac!Qeod 6f! you! love! $apanese! culture! andSor! relaxing! under! a! cherry! blossom! treeE!check!out!the!next!Sakura!'aki!festival!at!the!?rooklyn!?otanical! Jarden!,??JI)!On!Saturday!*pril!N/th!and!Sunday!*pril!Nzth!from!WO! am! to! z! pm! they! will! be! celebrating! traditional! and! contemporary! $apanese! culture! with! Taiko! 0rummingE! 3osplay! 5ashion! ShowE! Tea! 3eremoniesE!Yabuki!0anceE!Samurai!Sword!5ightingE!'anga!0rawingE! Vintage! YimonosE! ?onsai! Yids’! WorkshopsE! Wagashi! SweetsE! ??J! Parasol!Society!and!moreF!6!recommend!that!you!go!early!at!the!risk!of! waiting! in! line! because! this! festival! is! really! crowded! but! a! fantastic! opportunity!to!enjoy!this!wonderful!garden)!The!tickets!are!VN/E!but!free! for! members! ,you! can! get! your! membership! using! the! 60! NY3I)! The! ??J! is! located! at! W/O! 7astern! ParkwayE! ””O! Washington! *venueE! ?rooklynE!NY!WWNN/E!only!a!few!blocks!away!from!the!NE!HE!UE!/E!?!and! Q!subway!lines)!,http’SSwww)bbg)orgSdiscoverScherriesI The!other!option!is!to!just!enjoy!a!spectacular!indoor!orchid!show!at!the! New!York!?otanical!Jarden)!This!event!is!closing!on!*pril!W”!but!it!is! open! from! WO! am! to! z! pm! and! the! tickets! cost! VNOE! but! it! is! free! with! your!60!NY3!)!Take!the!?E!0E!or!U!train!to!?edford!Park!?lvd!Station)! 5rom!the!station!exitE!take!the!?xNz!bus!east!to!the!JardenGs!'osholu! Jate! entrance! OR! walk! eight! blocks! down! the! hill! on! ?edford! Park! ?lvd)! ,approximately! NO! minutesI)! http’SSwww)nybg)orgS exhibitionsSNOW/Sorchid(showS The/Mount/Sinai/Postdoc/PeriodicalC/April/2015 Upcoming events: The!Postdoc!Writing!Jroup!meets!every!Hrd!5riday!of!the!month!from! WN(Wpm)!3ome!and!improve!your!writingE!editing!and!reviewing!skillsF! When!and!where’!5ridays!at!noon!in!Less!3enter!room!WO(WNN!,WOth! floorI)!Their!next!meetings!are!*pril!W@th)!6f!you!have!writing!to!work! / onE! let! us! know! and! bring! a! few! copies! of! it! ,W(N! page! pieceE! ideally! abstract! or! introduction! and! no! results! or! methods! sectionsI)! The! group!will!even!read!3Vs!and!cover!letters)!6f!notE!just!bring!yourselfE! your!helpful!comments!and!a!penF!5ollow!the!6S''S!PostdocWriting! group!on!twitter!qPostdocWriting)!!To!join!the!mailing!list!visit’!http’SS mailman)mssm)eduSmailmanSlistinfoSpostdoc(writing The!writing!seminar!series!happens!every!Nnd!monday!of!the!month! from!U(/pm)!3ome!and!improve!your!writing!skillsF!When!and!where’! 'onday! 'ay! WWth! at! U! pm! in! the! *nnemberg! building! room! N/(/W! ,N/th! floorI)! 5ood! will! be! served)! Please! RSVP! to! jesica)levingstonmacleodqmssm)edu) Ways to keep in touch: •//Our/website:/http://icahnNmssmNedu/education/postdoctoralKtraining •//Follow/our/new/Twitter/account:/@MtSinaiPostdocs •//Join/our/Facebook/page:/“Mount Sinai Postdocs” ! •//Join/our/LinkedIn/group:/“Mount Sinai Postdoctoral Association” The Mount Sinai Postdoc Periodical Editors:/Jesica/Levingston/Mac/LeodC/Delaine//CeholskiC Astrid/StokerC/Catarina/SaioteC/Katie/Nolan/and/Cecilia/Sedano Page/2 Periodical!Crossword:!Science!101 By!Delaine!Ceholski Across 2B1Negative1ions1are1called1______B 5B1Eats1both1plants1and1animalsB1 6B1Your1mass1is1the1same1on1earth1and1the1moon1but1your1 ______1is1notB1 9B1The1center1of1an1atomB1 11B1The1process1by1which1DNA1is1copied1into1RNAB1 12B1The1only1metal1that1is1liquid1at1room1temperatureB1 13B1The1force1resisting1the1relative1motion1of1objects1 moving1against1each1other;1feeling1of1conflict1or1animosityB1 14B1The1place1where1a1population1of1organisms1liveB1 Down 1B1Mass1divided1by1volume1is1______B1 3B1The1process1by1which1a1substance1changes1from1a1 solid1to1a1gasB1 4B1The1process1by1which1water1becomes1cloudsB1 7B1An1educated1guess1or1proposed1explanation1for1a1 phenomenonB1 8B1Blue1litmus1paper1turns1______1under1acidic1 conditionsB1 10B1The1resistance1of1an1object1to1change1its1current1state1 of1motionB1 15B1An1indivisible1and1basic1unit1of1matterB11 Call!to!action! topic1suggestions opinion1articles photos fun1facts1 science1events1 Answers Across 2B1anions 5B1omnivore 6B1weight 9B1nucleus 11B1transcription 12B1mercury 13B1friction 14B1habitat1 Down 1B1density 3B1sublimation 4B1condensation 7B1hypothesis 8B1red 10B1inertia 15B1atom1 Send!us!your!contribution:! 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