Is It Depression or Something Else?

YO U AR E C O R DIALLY INVITED TO ATTEND
A THERAPEUTIC UPDATE (NON-CME) TO BE HELD AT THE
AMERICAN PSYCHIATRIC ASSOCIATION 168TH ANNUAL MEETING
Is It Depression or
Something Else?
DETECTION, DIAGNOSIS,
AND TREATMENT OF
PSEUDOBULBAR AFFECT*
MONDAY, MAY 18, 2015
7:00
pm
– 9:00
pm
CONCERT HALL • FAIRMONT ROYAL YORK
TORONTO, CANADA
DINNER WILL BE PROVIDED
F E A T U R E FA C U LT Y
Jason P. Caplan, MD, FAPA, FAPM
Chair of Psychiatry
Creighton University School
of Medicine
Phoenix Regional Campus
Phoenix, Arizona
Andrew J. Cutler, MD
CEO and Chief Medical Officer
Florida Clinical Research Center, LLC
Bradenton, Florida
Henry A. Nasrallah, MD
The Sydney Souers Professor
and Chairman
Department of Neurology and Psychiatry
Saint Louis University School
of Medicine
St. Louis, Missouri
*Pseudobulbar Affect (PBA) occurs secondary to a variety of otherwise unrelated neurologic conditions, and is characterized by involuntary,
sudden, and frequent episodes of laughing and/or crying.
In accordance with the US PhRMA Code on Interactions with Healthcare Professionals, attendance at this program is limited to only Healthcare
Professionals (Physicians, Nurse Practitioners, Physician Assistants, RNs, Clinical Pharmacists, Social Workers). Accordingly, attendance
by guests or spouses is not permitted.
This is a promotional program and no CME credits are offered. This program may include the provision of a modest meal. The
sponsors do not offer such a meal to healthcare professionals (HCPs) whose institutions prohibit such hospitality, nor do the
sponsors offer a meal where US federal or state laws (e.g., Vermont and Minnesota) limit an HCP’s ability to accept such
a meal. If you are licensed to practice in a state where meals are either prohibited and/or restricted and you accept a meal,
you understand that you will be required to reimburse the sponsors for the cost of this meal. Accordingly, please consult
your legal or ethics advisor regarding any applicable limitation before attending this program.
Please note that the sponsors are required to report the value of a provided meal pursuant to applicable US federal
and/or state laws.
Avanir products are not available nor approved for sale in Canada.
This activity will be held in conjunction with the APA Annual Meeting.
It is not considered part of the official scientific program of APA
and is not for CME credit.
PBA-0163-OTH-0315
© 2015 Avanir Pharmaceuticals, Inc. All rights reserved.
Sponsored by
You are cordially invited to attend
a Disease-State Theater supported by
FORUM Pharmaceuticals
COG
Cognitive Impairment and
Poor Functioning in Schizophrenia
Relationship and Neurobiology
Monday, May 18, 2015
1:00 pm–2:00 pm
Registration begins at 12:30 pm | Boxed lunch will be provided
APA Exhibit Hall, Product Theater
Metro Toronto Convention Centre, South Building | Toronto, Canada
PRESENTED BY:
Philip D. Harvey, Ph.D.
Leonard M. Miller Professor of Psychiatry
and Behavioral Sciences
Director, Division of Psychology
University of Miami Miller School of Medicine
Miami, FL
Anil K. Malhotra, M.D.
Professor of Psychiatry and Molecular Medicine
Hofstra North Shore-LIJ School of Medicine
Hempstead, NY
Director, Division of Psychiatry Research
The Zucker Hillside Hospital
Glen Oaks, NY
The industry product theater’s content and the views expressed therein are those of the
supporting company and not of APA or APF. This program does not provide CME credits.
Please join us for a book signing
by Philip D. Harvey, Ph.D.
Sunday, May 17, 2015 | 2:00 pm–3:00 pm
Please visit FORUM Pharmaceuticals at Booth #1539
For more information on cognitive impairment in schizophrenia, visit
www.NeedRecognition.com and www.CurrentPsychiatry.com/Cognition.
© 2015 FORUM Pharmaceuticals Inc. All rights reserved. FP-0149 3/15
in delivering science for better health
Attending the American Psychiatric Association meeting
in Toronto this May?
The Lancet Psychiatry is the independent voice for
mental health practitioners publishing original
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• Pick up complimentary journal copies
• Find out how to submit your article and much
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Come along to learn more about our journal plus:
Visit us in the Publishers’ Book Fair at booth #631.
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twitter.com/@thelancetpsych
THE LANCET® is a registered trademark of Reed Elsevier Properties SA, used under licence.
Psychiatry
www.thelancet.com/psychiatry
Available Early 2015
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Evaluate attention disorders and neurological functioning
in youth ages 4 to 7 with the Conners KCPT-2
Based on the well-established Conners CPT paradigm, the Conners Kiddie Continuous Performance Test 2nd Edition™
(Conners K–CPT 2™) takes half the time to complete and uses pictures of objects that are familiar to young children,
making it more appropriate for the new age range.
NEW to the
Second Edition:
• New normative data were collected to standardize the Conners K-CPT 2 scores.
• New scores and scoring algorithms were developed to help assessors pinpoint
the exact nature of the child’s attention problems.
• Computer-generated reports have been redesigned for easy interpretation.
MHS.com/KCPT2
Conners Continuous
Performance Tests
Conners Continuous
Performance Test 3rd Edition™
(Conners CPT 3™)
Administration Time
14 minutes
14 minutes
Paradigm
Click on non-X,
ignore X
Click on warned
high tone, ignore
unwarned high tone
Areas of Attention
Measured
Inattentiveness
Impulsivity
Sustained Attention
Vigilance
Inattentiveness
Impulsivity
Sustained Attention
Auditory Laterality
Auditory Mobility
Normative Sample
N=1400
N=1080
Conners Continuous
Auditory Test of Attention®
(Conners CATA®)
Assessment/
Interpretive
Report
Progress
Report
CPT 3
™
Detectability (d )
Hit Reaction Time (HRT)
HRT Standard Deviation (SD)
Variabilty
Ability to discriminate between targets (non-X)
and non-targets (X)
Missed targets
Incorrect responses to non-targets
Response speed
Response speed consistency
Variabilty of response speed consistency
Impulsivity
HRT
Commissions
Perseverations
Response speed
Incorrect responses to non-targets
Random or anticipatory responses (i.e., HRT < 100ms)
Sustained
HRT Block Change
Omissions by block
Commissions by block
Change in response speed across blocks of trials
Missed targets by block
Incorrect responses to non-targets by block
HRT Inter-Stimulus
Interval (ISI) Change
Omissions by ISI
Commissions by ISI
Change in response speed at various ISIs
Vigilance
Omissions
Inattentiveness Commissions
Attention
Missed targets by ISI
Incorrect responses to non-targets by ISI
CPT 3
™
Conners Continuous
Performance Test 3
Conners 3-P
Conners 3-P &
Conners CPT 3
CAARS
CAARS, &
Conners CPT 3
Overall Correct Classification (%)
83.9
88.4
89.1
92.7
Sensitivity (%)
86.0
81.8
89.5
87.3
65.4
94.6
73.1
97.3
Classification
Statistic
Specificity (%)
CATA
Conners Continuous
Auditory Test of Attention
Commissions
Hit Reaction Time (HRT)
HRT Standard Deviation (SD)
Ability to discriminate targets (warned high tone) from
non-targets (unwarned high tone)
Missed targets
Incorrect responses to non-targets
Response speed
Response speed consistency
HRT
Commissions
Perseverative Commissions
Response speed
Incorrect responses to non-targets
Incorrect responses before targets
Attention
HRT Block Change
Omissions by block
Commissions by block
Change in response speed across blocks of trials
Missed targets by block
Incorrect responses to non-targets by block
Auditory
HRT & Hits% Left vs. Right Ear
Preference for left vs. right targets
HRT & Hits% on Switch vs.
Non Switch Trials
Ability to switch attention from one ear to the other
Detectability (d )
Inattentiveness Omissions
Impulsivity
Sustained
Laterality
Auditory
Mobility
CATA
™
Conners Continuous
Auditory Test of Attention
Conners 3-P
Conners 3-P &
Conners CATA
Conners 3-P &
Conners CPT 3
Conners 3-P,
Conners CPT 3 &
Conners CATA
Overall Correct Classification (%)
83.9
88.4
88.4
93.8
Sensitivity (%)
86.0
81.8
91.2
85.5
89.5
87.3
94.7
92.7
Classification
Statistic
Specificity (%)
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