Chairmen’s invitation “Biophotonics is a multidisciplinary research area that utilizes light-based technologies, in medicine and life science. T he vision behind biophotonics is to gain a full understanding of the origin and molecular mechanisms of diseases to either prevent them or, at least, diagnose them early and precisely, followed by a treatment which is specifically adapted to individual needs.” (by “Lighting the way ahead”, P hotonics21 Str ategic Resear ch Agenda, 2010) Dear P ar ticipants to the IEEE BioP hotonics confer ence, After the success of the fir st inter national IEEE BioP hotonics Wor kshop (P ar ma, Italy 2011) and the second one (Taipei, Taiwan, 2013), the Institute of Applied P hysics of the National Resear ch Council of Italy and the IEEE Italy Section ar e pleased to welcome you to the thir d appointment of the ser ies. Fr om the beginning of the Inter national Wor kshop BioP hotonics2011 or ganization, it has been clear that talking about biophotonics would have meant to gather scientists with many differ ent exper iences, competences and backgr ound to cover all differ ent aspects of this new and emer ging field. The IEEE BioP hotonics meetings has been established as a high-level meeting in the ar ea of light-based techniques for medicine, life science, agr icultur e, envir onmental science and many other ar eas of application. Being at BioP hotonics2015 is thus a unique oppor tunity to inter act with a multidisciplinar y and fer tile for um of exper ts, wher e r esear cher s and pr ofessionals exchange their specific knowledge and exper iences. The confer ence will have thr ee P lenar y Sessions with keynote speaker s fr om all over the wor d and four teen fur ther or al sessions plus two poster ones and an exhibitor showcase. The main topics compr ise: diagnostics and ther apeutics applications; imaging; integr ated optical devices; micr oscopy; modeling; nano biophotonics; optofluidic platfor ms; sensing and plasmonic platfor ms; spectr oscopy. Mor e than thir ty invited speaker s will enr ich the confer ence pr esenting the activity of impor tant Eur opean and inter national r esear ch gr oups. Also, a joint session with ICOB 2015 will take place in the after noon of May 20th within the so-called "Flor ence Biophotonics Week". We ar e confident that between abstr acts, technical sessions, food and city tour s, all par ticipants will contr ibute to lead a ver y r ewar ding confer ence. Have a gr eat time in Flor ence at IEEE BioP hotonics2015! Rober to P ini Stefano Seller i 1 BioPhotonics 2015 Florence, Italy May 2 0 -2 2 , 2 0 1 5 Conference Chairs Roberto Pini, Institute of Applied Physics-CNR Florence (Italy) Stefano Selleri, University of Parma (Italy) Steering Committee Roberto Pini, Confer ence Chair man, Institute of Applied P hysics-CNR Flor ence (Italy) Stefano Selleri, Confer ence Chair man, Chair of IEEE P hotonics Society Italy Chapter , Univer sity of P ar ma (Italy) Ermanno Cardelli, Chair of IEEE Italy Section, Univer sity of P er ugia (Italy) Francesco Baldini, SIOF, Institute of Applied P hysics-CNR Flor ence (Italy) Technical-Scientific Committee Peter E. Andersen, T echnical University of Denmark (Denmark) Romeo Bernini, Institute for Electromagnetic Sensing of the Environment-CNR (Italy) Annamaria Cucinotta, University of Parma (Italy) Pietro Ferraro, Istituto di Cibernetica "E. Caianiello"-CNR Naples (Italy) Maria Minunni, University of Florence (Italy) Lorenzo Pavesi, Univer sity of Tr ento (Italy) Francesco S. Pavone, LENS and University of Florence (Italy) Stavros Pissadakis, Foundation for R esearch and T echnology Hellas - FOR T H, Crete (Greece) Juergen Popp, Leibniz Institute of Photonic T echnology, Jena (Germany) Roberto Rella, Institute for Microelectronic and Microsystems-CNR , Lecce (Italy) Francesca Rossi, Institute of Applied Physics-CNR Florence (Italy) Roberto Sabella, Ericsson e Distretto T oscano FOR T IS (Italy) Local Organizing Committee Lucia Cavigli Francesca Tatini Alessandro Agostini Lucia Benelli Chiara Berrettoni Fulvia Ciurlia Giovanna Diprima Chiara Liserani Von Berger Conference Venue Area di Ricerca di Firenze - CNR Via Madonna del Piano 5 0 0 1 9 Sesto Fiorentino Building F - Meeting center For I nformation http://biophotonics2 0 1 5 .ifac.cnr.it InfoBioPhotonics2 0 1 5 @ifac.cnr.it 2 Technical Program Wednesday 20th May 2015 08:00-08:45 Registr ation 08:45-08:55 Welcome Plenary I- Aula Magna 08:55-09:20 We1.1(Invited) 4 D Nanoscopy 2 .0 . A great immediate challenge, 1 Diaspr o, A. 1 NanoBioPhotonics, Istituto Italiano di T ecnologia, Department of Physics, Università di Genova, Nik on Imaging Center, NIC@IIT , Genova (Italy) 09:20-09:45 We1.2(Invited) Accelerating Progress in Light Sheet Microscopy, 1 Dholakia, K. 1 SUPA, University of St. Andrews, North Heugh, Fife (UK) Shaped light fields namely pr opagation invar iant (‘non-diffr acting’) light fields and complex beam shaping. This talk will descr ibe such fields and look at their application to single plane illumination (light sheet) micr oscopy (SP IM). This modality uses or thogonal detection for r apid imaging of lar ge, thr ee-dimensional, samples of living tissue. Illumination with a thin sheet of light ensur es high contr ast by minimizing the fluor escent backgr ound. 09:45-10:10 We1.3(Invited) Quantitative spectrally resolved optoacoustic imaging, 1 1 1 2 Ger r it Held , Tigr an P etr osyan , H. Günhan Akar çay , Linda Ahnen , Mar tin 2 1 1 Wolf , Michael J aeger , and Mar tin Fr enz 1 Institute of Applied Physics, University of Bern, Bern (Switzerland), 2 University Hospital Zuerich, University of Zuerich, Zuerich (Switzerland) Spectr al quantitative optoacoustic imaging is based on the knowledge of the local fluence distr ibution, which can exper imentally be deter mined either by near -infr ar ed imaging or by single point illumination optoacoustic imaging. Phantom exper iments show that both techniques allow to quantitatively r etr ieve the spectr al infor mation of embedded absor ber s. 10:10-10:30 Coffee Br eak 3 Parallel Sessions We2 : Spectroscopy and Imaging I - Aula Magna 10:30-10:55 We2.1(Invited) Shedding new light on cells with coherent multiphoton microscopy, 1 Bor r i, P . 1 School of Biosciences, Cardiff University, Cardiff (UK) We have developed in our labor ator y sever al home-built CARS micr oscopes featur ing innovative excitation/detection schemes. Fur ther mor e we have invented and demonstr ated a novel imaging modality, based on the r esonant Four -Wave Mixing (FWM) of colloidal nanopar ticles. I will pr esent our latest pr ogr ess with both techniques and their applications to cell imaging 10:55-11:20 We2.2(Invited) Fluorescent imaging of tumor metabolic state, 1 Zagaynova, E. 1 Nizhny Novgorod State medical academy, Nizhny Novgorod (R ussia) 11:20-11:35 We 2.3 Three-dimensional imaging of entire murine intestine with Light Sheet Microscopy, 1 1 1 2 Daniela De Stefano , Ilenia Sana , Luigi Maiur i , Giulio Simonutti , Alessia 2 1 2 Candeo , Gianluca Valentini , Andr ea Bassi 1 IER FC, Fondazione ONLUS, Ospedale San R affaele, Milano (Italy), 2 Dipartimento di Fisica, Politecnico di Milano, Milano (Italy) Mur ine or gans such as intestine tissue can be imaged with Light Sheet Micr oscopy in depth at high r esolution, but accumulating a lar ge dataset, difficult to pr ocess and inter pr et. We developed a pr ocessing r outine to vir tually unfold the sample, obser ve it layer -by-layer , identify distinct villi and statistically compar e multiple samples. 11:35-11:50 We2.4 Multispot multiphoton Ca2 + imaging in acute myocardial slices, 1,4 2 1,4 2 Giulia Bor ile , Claudio de Maur o , Andr ea Ur bani , Domenico Alfier i , 3 1,4 Fr ancesco S. P avone , Mar co Mongillo 1 University of Padova, Department of Biomedical Science, Padova (Italy), 2 3 Light4T ech Firenze s.r.l., Scandicci, Florence (Italy), University of Florence, 4 Department of Physics, Sesto F.no (Italy), Venetian Institute of Molecular Medicine, Padova (Italy) Multispot multiphoton micr oscopy (MMM) has been applied for the fir st time to image Ca2+ dynamics in myocar dial tissue. We demonstr ated that MMM par allel scanning with 16 laser beamlets enables the investigation of fast occur r ing Ca2+ dependent signals in the living cells within intact hear t slices. 11:50-12:05 We2.5 Femtosecond Stimulated Raman Spectroscopy and preliminary steps for nonlinear microscopy, 1,2 1 1 2 1 1 A. D’Ar co , M. Indolfi , M. A. Fer r ar a , L. Zeni , I. Rendina , L.Sir leto 1 National R esearch Council(CNR ) -Institute for Microelectronics and 4 2 Microsystems, Napoli (Italy), Second university of Naples (SUN), Department of Information Engineering, Napoli (Italy) SRS is a shot_noise limited highly sensitive tool of vibr ational spectr oscopy. SRS is fr ee fr om the non-r esonant backgr ound, exhibits an identical spectr um as the spontaneous Raman, it is linear ly pr opor tional to the concentr ation of the analyte. In this paper we descr ibe the r ealization of a SRS nonlinear micr oscope and we discuss the main exper imental issue for its implementation 12:05-12:20 We2.6 Wavelet filter for Femtosecond Stimulated Raman Spectroscopy: a new approach brings new horizons, 1,2 1 1 1 Mir oslav Kloz , J ör n Weissenbor n , Yusaku Hontani , J ohn T.M. Kennis 1 Department of Physics, VU University, Amsterdam (T he Netherlands) 2 Institute of Physics ASCR , v.v.i. (FZU), ELI-Beamlines Project Prague (Czech R epublic) We developed an innovative way of per for ming femtosecond stimulated Raman exper iment. Instead of using nar r owband pulses we use shaped br oadband pulses. In this way the signal to noise r atio and fidelity of exper iments r ises by at least a one or der of magnitude. We3 : Diagnostics and Therapeutics Applications I- Room 2 10:30-10:55 We3.1(Invited) Optical assessment of blood microrheology in norm, disease and at interaction with nanoparticles, 1,2 1 1,2 1 3 A.V. P r iezzhev , A.E. Lugovtsov , S.Yu. Nikitin , K. Lee , V.D. Ustinov , 1,4 4 4 5 6 O.E. Fadyukov , M.D. Lin ,V.B. Koshelev , Yu.I. Gur finkel , M. Kinnunen , 7 7 7,8 C.-L. Cheng , E.V. P er evedentseva , A.V. Kar menyan 1 Physics Faculty, Lomonosov Moscow State University, Moscow (R ussia), 2 International Laser Centre, Lomonosov Moscow State University, Moscow 3 (R ussia), Faculty of Computational Mathematics and Cybernetics, Lomonosov 4 Moscow State University, Moscow (R ussia), Faculty of Medicine, Lomonosov 5 Moscow State University, Moscow (R ussia), R esearch Clinical Center of JSC 6 «R ussian R ailways», Moscow (R ussia), University of Oulu, Oulu (Finland) 7 8 National Dong Hwa,University, Hualien (T aiwan), National Yang-Ming University, T aipei (T aiwan) P ossibilities to optically assess the major par ameter s of blood micr or heology and micr ocir culation in nor m, disease and at inter action with nanopar ticles ar e demonstr ated. P ossibilities of using them as optical biomar ker s of diseases (e.g., diabetes and hyper tension), or of the consequences of inter action of blood components with nanopar ticles ar e discussed. 10:55-11:20 We3.2(Invited) Optical techniques for distant assessment of human skin, 1 Spigulis, J . 1 Biophotonics Laboratory, Institute of Atomic Physics and Spectroscopy, University of Latvia, R iga (Latvia) 5 Thr ee optical techniques for distant mapping of skin diagnostic indices, chr omopor es, fluor ophor es and micr ocir culation par ameter s ar e discussed. The technologies have been implemented in exper imental pr ototype devices and ar e validated in labor ator y and clinics. 11:20-11:35 We3.3 Complex optical method of cancer detection and visualization, 1 1 1 Ivan A. Br atchenko , Dmitr y N. Ar temyev , Oleg O. Myakinin , J ulia A. 1 1 2 Khr istophor ova , Dmitr y V. Kor nilin , Alexander A. Mor yatov , Valer y P . 1 2 Zakhar ov , Ser gey V. Kozlov 1 2 Samara State Aerospace University, Samara (R ussia), Samara State Medical University, Samara (R ussia) Complex investigation of malignant tumour s diagnosis was per for med involving combined optical coher ence tomogr aphy, Raman spectr oscopy and fluor escence analysis. Combined setup was used for common skin and lung malignant tumour s in vivo and ex vivo analysis and for pr ecise tissue mor phology visualization. The complex method could identify cancer s with >90% accur acy. 11:35-11:50 We3.4 Laboratory full-field transmission X-ray microscopy and applications in life science, 1,2 1,2 1,3 4 1,2 C.Seim ,A. Dehlinger , B. Kanngießer , K.Reineke , H. Stiel 1 Berlin Laboratory for innovative X-ray technologies (BLiX), Berlin 2 3 (Germany), Max-Born-Institut, Berlin (Germany), T echnische Universität 4 Berlin, Institut für Optik und Atomare Physik , Berlin (Germany), LeibnizInstitut für Agrartechnik Potsdam- Potsdam (Germany) Zone plate based soft X-r ay micr oscopy in the water window offer s r esolution in the nanometer r egime combined with natur al contr ast and a high penetr ation depth for hydr ated samples. This enables nanoscale investigations of biological objects in thr ee dimensions 11:50-12:05 We3.5 Towards next generation time-domain devices for increasing depth sensitivity in diffuse optics, 1 2 2 3 Andr ea Far ina , Alber to Dalla Mor a , Davide Contini , Simon R. Ar r idge , 4 5 5 6 Fabr izio Mar telli , Alber to Tosi , Gianluca Boso , Tur gut Dur dur an , Edoar do 2 2 1,2 Mar tinenghi , Alessandr o Tor r icelli , Antonio P iffer i 1 Istituto di Fotonica e Nanotecnologie, Consiglio Nazionale delle R icerche, 2 Milano (Italy), Dipartimento di Fisica, Politecnico di Milano, Milano (Italy), 3 Department of Computer Science, University College London, London (UK), 4 Dipartimento di Fisica e Astronomia, Università degli Studi di Firenze, Firenze 5 (Italy), Dipartimento di Elettronica, Informazione e Bioingegneria, 6 Politecnico di Milano, Milano (Italy), ICFO-Institut de Cències Fotòniques, Castelldefels, Barcelona (Spain). We pr esent and validate a miniatur ised Time-Domain (TD) pr obe, embedding a pulsed Ver tical-Cavity Sur face-Emitting Laser (VCSEL), and a Single-P hoton Avalanche Diode (SP AD) or a Silicon P hotomultiplier (SiPM). These technologies show the way towar ds compact and wear able TD pr obes with or der s of magnitude r eduction in size and cost. 12:05-12:20 We3.6 6 Field-portable and cost-effective devices for biological and chemical assays, 1 1 2 Annamar ia Cucinotta , Stefano Seller i , Alessandr o Tonelli , Alessandr o 2 2 Candiani , Michele Sozzi 1 Information Enginnering Department, University of Parma, Parma (Italy), 2 DNAPhone S.R .L., Parma (Italy) Consumer electr onics is dr amatically boosting the employment of smar t, low cost devices for specific tasks like chemical assays. The r esults pr esented her ein ar e focused on the successful application of the cr edit-car d sized computer Raspber r y P i and customized optics to food chemistr y assays. The developed device exhibited compar able r esults with labor ator y-based appr oaches. 12:20-13:20 Lunch 13:30-13:45 Tr ansfer Villa La Quiete Joint Session with ICOB2 0 1 5 14:00-16:30 Success Stories Chair s: Dennis Matthews, Quingmin Luo Speaker s: 14:00–14:30 Lor enzo Tar getti 14:30–15:00 David Sampson 15:00–15:30 J uer gen P opp 15:30–16:00 Antonio P lffer i 16:00–16:30 Sailing He 16:30:17:30 Coffee Br eak 17:30-18:45 Success Stories Chair s: Rober to P ini, Sailing He Speaker s: 17:00-17:30 Dennis Matthews, UC Davis Health System 17:30-18:00 Tur gut Dur dur an, Institute of P hotonic Science 18:00-18:30 Qingmin Luo, Br itton Chance Center for Biomedical P hotonics 18:30-18:45 Laur a Mar cu, UC Davis Biomedical Enginieer r ing 18:45-19:00 ICOB2015 Closing r emar ks 19:15-19:30 Tr ansfer downtown Flor ence 19:30-20:30 Welcome Cocktail at Caffetter ia delle Oblate 21:00-22:00 Special event celebr ating the International Year of Light 2 0 1 5 at Biblioteca delle Oblate 7 Thursday 20th May 2015 08:00-08:30 Registr ation Plenary II- Aula Magna 08:30-08:55 Th1.1(Invited) Biosensing with silicon photonics, 1 1 1 2 P aolo Bettotti , Tatevik Chalyan , Davide Gandolfi , Mher Ghulinyan , Romain 1 3 3 2 Guider , Laur a P asquar dini , Cecilia P eder zolli , Geor g P ucker , Fer nando 1 2 1 1 Ramir o Manzano , AlinaSamusenko , Mar ina Scar pa , Lor enzo P avesi 1 Nanoscience Laboratory, Department of Physics, University of T rento, T rento, 2 (Italy), Center for Material and Microsystems, Bruno Kessler Foundation, 3 T rento (Italy), LaBSSAH, Fondazione Bruno Kessler, Povo (Italy) Silicon photonics based biosensor s ar e r eviewed with examples for sensing pr oteins, aller gens and aflatoxin in milk 08:55-09:20 Th1.2(Invited) Compact, Semiconductor-based Light Sources for Biophotonics, 1 P eter Ander sen , 1 T echnical University of Denmark (Denmark ) 09:20-09:45 Th1.3(Invited) Optimization of metal nano-materials for the development of LSPR-based optical fibre sensors 1 1 1 1 T Sun , M H Tu , J Cao and K T V Gr attan 1 School of Mathematics, Computer Science and Engineering, City University London (UK) This paper is focused on the development of localised sur face plasmon r esonance (LSP R)based optical fibr e sensor s, thr ough the optimization of the coated metal nano-mater ials. The highest sensitivity of an LSP R sensor coated with gold hollow nanocages has been demonstr ated to be ~1933 nm/RIU. 09:45-10:05 Coffee Br eak Parallel Sessions Th2 : Diagnostics and Therapeutics Applications II - Aula Magna 10:05-10:30 Th2.1(Invited) Corneal Transparency, Light Scattering and Coherence Loss, 8 1 1 2 Kar sten P lamann , Fatima Alahyane , Emmanuel Beaur epair e , Zacar ia 1 Essaïdi 1 Laboratoire d’optique appliquée, ENST A ParisT ech –École polytechnique – 2 CNR S Palaiseau cedex (France), Laboratoire d'optique et biosciences, École polytechnique –CNR S –Inserm, 91128 Palaiseau (France) In ear lier studies we have wor ked on light scatter ing in cor nea in or der to impr ove laser sur gical methods. We her e pr esent new optical measur ements on por cine cor nea based on digital hologr aphy and thir d har monic gener ation in view of identifying specific light scatter ing mechanisms and quantifying their impact on cor neal tr anspar ency 10:30-10:55 Th2.2(Invited) Automatic Temperature Guided Retinal Photocoagulation, 1,2 1,2 3 1,2 1,2 R. Br inkmann , A. Baade , S. Koinzer , W. Schwar zer , K.Schlott , Y. 2 3 Miur a , J . Roider 1 2 Medical Laser Center Lübeck , Lübeck (Germany), Institute of Biomedical 3 Optics, University of Lübeck , Lübeck (Germany), Department of Ophthalmology, University of Kiel, Kiel (Germany) The str engths of r etinal photocoagulation lesions ar e automatically contr olled by means of an optoacoustic based feedback technique, which acquir es the temper atur e r ise in r ealtime. The technique was investigated on r abbits by using differ ent initial laser par ameter . Lesions wer e evaluated by a fundus camer a with r espect to unifor m lesion sizes. 10:55-11:10 Th2.3 Gas in Scattering Media Absorption Spectroscopy for Sinusitis and Otitis Diagnostics, 1 1 1 1 1,2 Hao Zhang , J ing Huang , Tianqi Li , HuiyingLin , Katar ina Svanber g and 1,2 Sune Svanber g 1 Center of Optical and Electromagnetic R esearch, South China Normal 2 University, Guangzhou (China), Lund Laser Centre, Lund University, Lund (Sweden) We use tuneable diode laser spectr oscopy to non-invasively study fr ee gas in human sinus cavities and the middle ear . Good signal stability was found in healthy sinus volunteer s, and the possibility to assess fr ee gas thr ough the ear dr um in back-scatter ing geometr y was established in phantom exper iments. 11:10-11:25 Th2.4 Fluorescence spectroscopy of blood plasma of patients with diabetes mellitus, 1 2 1 Evgeny Shir shin , Tatiana Tikhonova , Victor Fadeev and Alexander 1,2 P r iezzhev 1 M.V. Lomonosov Moscow State University, Physical Department, Moscow 9 2 (R ussia), M.V. Lomonosov Moscow State University, International Laser Center, Moscow (R ussia) We pr esent the r esults of the investigation of blood plasma of patients with diabetes mellitus using steady-state and time-r esolved fluor escence spectr oscopy aimed at the development of fluor escence indicator s of metabolic syndr ome 11:25-11:40 Th2.5 Estimation of tissue optical properties between different grades and stages of urothelial carcinoma using reflectance spectroscopy 1 1,2 3 4 Sur esh Anand , Riccar do Cicchi , Fabr izio Mar telli , Alfonso Cr isci , Gabr iella 4 4 1,2, 3 Nesi , Mar co Car ini , Fr ancesco S. P avone 1 European Laboratory for Non-Linear Spectroscopy (LENS), University of 2 Florence, Sesto Fiorentino (Italy), National Institute of Optics, National 3 R esearch Council (INO-CNR ), Florence (Italy), Department of Physics, 4 University of Florence, Sesto Fiorentino (Italy), Division of Urology, Department of Surgical and Medical Critical Area, University of Florence, Florence (Italy) 11:40-11:55 Th2.6 Characterization of Tumour Laser Ablation Probes with Temperature Measuring Capabilities, 1 1 1 1 1 Yu Liu , Hao Yu , R iccardo Gassino , Andrea Braglia , Massimo Olivero , 2 1 1 Daniele T osi , Alberto Vallan , Guido Perrone 1 Dept. of Electronics and T elecommunications, Politecnico di T orino, T orino 2 (Italy), School of Engineering, Nazarbayev University, Astana (Kazak hstan) The paper r epor ts on the development and char acter ization of an innovative all-optical laser deliver y fibr e pr obe for cancer cell ablation with simultaneous temper atur e sensing capabilities. The pr obe integr ates gr ating-based temper atur e sensor s and a micr ostr uctur ed tip sur face for adapting the beam diffusion to the tumour geometr y. 11:55-12:10 Th2.7 CO2 and Nd: YAP lasers irradiation on CAD/CAM Ceramics: SEM, EDS and thermal studies, Ahmed El Gamal1, Car lo For naini1,2,3, J ean P aul Rocca 1,2, Omid Muhamad 1, Etienne Medioni1,2, Annamar ia Cucinotta 3, Nathalie Br ulat-Bouchar d 2 1 Micoralis laboratoy EA 7354, University of Nice Sophia Antipolis, Nice (France), 2R estorative Dentistry and Endodontics Department, Faculty of Dentistry, University of Nice-Sophia Antipolis, Nice (France), 3Information Engineering Department, University of Parma, Parma (Italy) To investigate the inter action of infr ar ed light on CAD/CAM cer amics sur faces, sixty CAD/CAM cer amic discs wer e pr epar ed and divided into two differ ent gr oups: lithium disilicate cer amics and Zir conium cer amics and ir r adiated with CO 2 laser and Nd:YAP 10 laser at 10W. Both the two wavelengths modify CAD/CAM sur face without chemical composition modification Th3 : Sensing and Optofluidic Platforms - Room 2 10:05-10:30 Th3.1(Invited) Photonics-enhanced polymer optofluidic chips: from high-tech prototyping platform to applications, 1 1 1 1 Heidi Ottevaer e , Diane De Coster , J ür gen Van Er ps , Michael Ver vaeke , 1 Hugo Thienpont 1 Vrije Universiteit Brussel, Department of Applied Physics and Photonics, Brussels Photonics T eam (B-PHOT ), Pleinlaan 2, B-1050 Brussels (Belgium) We will highlight ver satile photonics-enhanced polymer optofluidic chips fabr icated with our high-tech pr ototyping platfor m and developed for absor bance, fluor escence and Raman spectr oscopy measur ements. These chips pave the way towar ds multifunctional, low-cost, por table, r obust, and, ultimately, disposable lab-on-a-chip systems that can be used in the field and for point-of-car e diagnostic applications. 10:30-10:55 Th3.2(Invited) Ultrasensitive DNA detection by PNA-modified Photonic Crystal Fibers (PCFs), 1 Rober to Cor r adini 1 Department of Chemistry, Università di Parma, Parma (Italy) In this lectur e we will descr ibe the steps we have under taken to achieve the goal of using P CF fiber s as optofluidic genosensor s. P CF containing Br agg gr ating, inter nally modified with peptide nucleic acid (P NA) pr obe, was found suitable for obtaining an optofluidic device for the detection of unamplified genomic DNA. 10:55-11:10 Th3.3 Characterization of SiON microring resonators for biosensing applications, 1 1 1 2 3 T. Chalyan , D. Gandolfi , R. Guider , L. P asquar dini , A. Samusenko , C. 2 3 1 P eder zolli , G. P ucker , L. P avesi 1 Nanoscience Laboratory, Department of Physics, University of T rento, T rento 2 3 (Italy), LaBSSAH, Fondazione Bruno Kessler, Povo (Italy), Centre for Materials and Microsystems, Fondazione Bruno Kessler, Povo (Italy) We pr esented a study on micr or ing-based photonic biosensor s, for Aflatoxin M1detection.We measur ed the bulk Sensitivity (S) and Limit of Detection (LOD) as a function of the waveguide composition and dimensions. In addition, we per for med sensing measur ements on functionalized devices using Aflatoxin M1 solutions of var ious concentr ations (down to ~10nM). 11:10-11:25 Th3.4 11 Optical whispering gallery mode microresonators for biosensing, 1,2 2 2 2 1,2 2 Far nesi D. , Baldini F. , Bar ucci A. , Ber neschi S. , Cosci A. , Cosi F. , 2 2 1,2 1,2 2 Giannetti A. , NunziConti G. , P elli S. , Righini G.C. , Sor ia S. , Tombelli S. 2 2 , Tr ono C. 1 2 Enrico Fermi Center, 00184 R oma (Italy), Institute of Applied Physics “Nello Carrara”, CNR , Sesto Fiorentino (Italy) Mor phological dependence of optical Whisper ing Galler y Mode (WGM) micr or esonator s can be well exploited in biosensing. Any var iation in the r esonator size or in the r efr active index of the sur r ounding medium causes a shift of the r esonance position. By measur ing this shift, highly sensitive label-fr ee biosensor s can be developed. 11:25-11:40 Th3.5 Hybrid Silicon-PDMS optofluidic ring resonator, 1 1 1 1 G. Testa , I.A. Gr imaldi , G. P er sichetti , R. Ber nini 1 Istituto di R ilevamento Elettromagnetico dell’ambiente, CNR , Napoli (Italy) Optofluidic appr oaches for r ing r esonator s take advantages fr om the high sensitivity of the r esonant photonic str uctur e and simpler fluid handling char acter istic due to fluidic integr ation. An integr ated optofluidic r ing r esonator based on hybr id ARROW is pr esented. 11:40-11:55 Th3.6 Development of a fluorescence-based optical sensor for nucleic acid detection, 1 1 1 2 Katia Tr agni , Annamar ia Cucinotta , Stefano Seller i , Alessandr o Tonelli , 1 1 Alessandr o Candiani , Michele Sozzi 1 2 Dept. of Information Engineering, University of Parma, Parma (Italy), Dept. of Chemistry, University of Parma, Parma (Italy) Afluor escence-based optical sensor for nucleic acid detection is demonstr ated. It offer s many advantages such as por tability, low ener gy consumption, and r apid monitor ing and it can detect vir uses in small concentr ations. 12:10-13:10 Poster Session I 13:10-14:00 Lunch Parallel Sessions Th4 : Integrated Optical Devices- Aula Magna 14:00-14:25 Th4.1(Invited) Red Blood Cell as Optfluidic Tuneable Lens, 12 1 1 1,2 2 Fr ancesco Mer ola , Lisa Miccio , P asquale Memmolo , P aolo Netti , P ietr o 1 Fer r ar o 1 2 CNR -Istituto “E. Caianiello”, Pozzuoli (NA) (Italy), Center for Advanced Biomaterials for Health Care@CR IB, Istituto Italiano di T ecnologia, Napoli (Italy) For the fir st time a r ed blood cell is used as tunable micr olens, dr iven by the solution osmolar ity var iation. Applications in diagnostics and micr oscopy ar e for eseen. 14:25-14:50 Th4.2(Invited) Fiber based and Fiber Lasers sources for medical applications, 1 Taccheo, S. 1 Swansea University, Swansea (UK) This talk will pr esent r esults and futur e r esear ch dir ections in the field of laser sour ces than will impact biomedical r esear ch in the coming year s. In par ticular the talk will focus on Fibr e-Laser s based sour ces since their r eliability and flexibility, explor ing applications r anging fr om imaging, to cancer detection and customized implants. P ar ticular emphasize will be give to the availability in the near futur e of new wavelength, par ticular ly in the medium-infr ar ed, for biomedical diagnostics and what could be expected to be available to biomedical r esear cher s and clinicians aiming to use laser based tools for their activity. 14:50-15:05 Th4.3 Integrated III-V semiconductor platform with capillary fill micro-fluidics for chip-based flow cytometry, 1 2 1 1 1 R.Thomas , M.D.Holton , S.Gilgr ass , A.Sobiesier ski , P .M.Smowton , 2 3 H.D.Summer s , D. Bar r ow 1 School of Physics and Astronomy, Cardiff University, T he Parade, Cardiff 2 (UK), Centre for Nanohealth, Swansea University, Singleton Park , Swansea 3 (UK), Cardiff School of Engineering, Cardiff University, T he Parade, Cardiff (UK) We pr esent a pr ototype of a III-V semiconductor platfor m with integr ated laser /detector s and capillar y fill micr o-fluidics for flow cytometr y in point-of-car e and r esour ce poor settings. Results of a micr o-bead detection exper iment demonstr ate the ar r ayed laser s and detector s pr ovide sub-μs time r esolution with multiple inter r ogation events per cell. 15:05-15:20 Th4.4 A parallel microfluidic device for hydrodynamic focusing of acute lymphoid leukemia cells, 1 1 1 1 2 1 S.Tor ino , M. Iodice , I. Rendina , G. Coppola , E. Schonbr un , D. P assar o 1 Institute for Microelectronics and Microsystems, National R esearch Council, 2 Naples (Italy), R owland Institute at Harvard, Harvard University, Cambridge MA (USA) 13 15:20-15:35 Th4.5 Amorphous silicon photodiodes as a new platform for chemiluminescent lateral flow immuneassay quantitative detection, 1 2 3 2 Mar a Mir asoli , Giampier o De Cesar e , Laur a Anfossi , Domenico Caputo , 4 1 3 3 Augusto Nascetti , M. Zangher i , Fabio Di Nar do , Claudio Baggiani , Aldo 1 Roda 1 Department of Chemistry, Alma Mater Studiorum, University of Bologna, 2 Bologna (Italy), Department of Information, Electronic and T elecommunication Engineering, Sapienza University of R ome, R ome (Italy), 3 4 Department of Chemistry, University of T urin, T urin (Italy), Department of Astronautics, Electrical and Energy Engineering, Sapienza University of R ome, R ome (Italy) A simple, accur ate, r apid and ultr asensitive biosensor based on Chemiluminescence Later al Flow Immunoassay technology was developed for quantitative detection of human ser um albumin in ur ine samples. To pr ovide maximum detectability in a compact integr ated device, an hydr ogenated amor phous silicon photodiode ar r ay was employed for CL signal detection. Th5 : Modeling - Room 1 14:00-14:25 Th5.1(Invited) Cloud Monte Carlo based platform for the needs of Biophotonics and Biomedical Optics, 1,2 3 1 Igor Meglinski , Steven J acques , Alexander Dor onin 1 Jack Dodd Centre for Quantum T echnology, Department of Physics, 2 University of Otago, Dunedin, (New Zealand), Laboratory of Opto-Electronics and Measurement T echniques, University of Oulu, Oulu (Finland), 3 Departments of Biomedical Engineering and Dermatology, Oregon Health & Science University, Portland, OR (USA) Engineer ing design and optimization of optical diagnostic and imaging systems r equir e a clear under standing of light-tissue inter action. We pr esent the cloude Monte Car lo based platfor m for the needs of Biophotonics, including modeling of fluence r ate distr ibution, skin r eflectance spectr a, Optical Coher ence Tomogr aphy, tissue polar imetr y, coher ent back scatter ing, fluor escence and other . 14:25-14:50 Th5.2(Invited) New methods for acquiring the 3 -D structure and contents of live cells without labeling, 1 1 Natan T. Shaked and Mor Habaza 1 Department of Biomedical Engineering, Faculty of Engineering, T el-Aviv 14 University, T el-Aviv (Israel) We pr opose new methods for noninvasive acquisition of the 3-D r efr active-index str uctur e of live cells in suspension without using any labelling. The methods ar e based on the acquisition of off-axis inter fer ogr ams of the cell fr om differ ent angles using exter nal inter fer ometr ic module, while fully r otating the cell using micr o-manipulations. 14:50-15:05 Th5.3 An Eigenmode Expansion Method for Rigorous Simulations of Light Scattering From Living Cells, 1,2 1 1,2 J ir í P etr áč ek , Yasa Eksioglu , Radim Chmelík 1 Institute of Physical Engineering, Faculty of Mechanical Engineering, Brno University of T echnology, T echnick á 2, 616 69 Brno (Czech R epublic), 2 CEIT EC - Central European Institute of T echnology, Brno University of T echnology, T echnick á 10, 616 00 Brno (Czech R epublic) We pr esent a novel application of the eigenmode expansion technique for r igor ous simulation of light scatter ing fr om living cells. The for mulation uses numer ically stable scatter ing matr ices and a per tur bation appr oach based on the r igor ous coupled-mode theor y. We demonstr ate conver gence pr oper ties and discuss pr actical applicability of the technique. 15:05-15:20 Th5.4 Photodynamic therapy: good news from computational approaches, 1 1 1 1 Nino Russo , Mar ta E. Alber to , Glor ia Mazzone , Br una C. De Simone , 1 1 Tiziana Mar ino , Emilia Sicilia 1 Dipartimento di Chimica e T ecnologie Chimiche, Università della Calabria, I87036 R ende (Italy) The possibility to design new photosensitizer s active in photodynamic ther apy (P DT) star ting fr om computed electr onic and geometr ical pr oper ties (absor ption wavelengths shifted in the Near Infr ar ed Region, singlet-tr iplet ener gy gaps and spin-or bit matr ix elements lar ge enough to allow an efficient inter system spin cr ossing) can be r eliably pr edicted by Density Functional Theor y. 15:20-15:35 Th5.5 Analysis of Light Transport Phenomena in Photosynthetic Microbial Cultures, 1 1 1 Hashem Asghar nejad , Mohammad-Hossein Sar r afzadeh , Reza Zar ghami 1 UNESCO Chair on Water R euse, School of Chemical Engineering, College of Engineering, University of T ehran, T ehran (Iran) In this paper a r elation is made between light intensity and cell concentr ation in a photosynthetic micr obial cultur e like photobior eactor s. Pr esent study is based on the diffusion of photons in a media and mathematical equations ar e der ived thr ough Boltzmann equation and the diffusion analogy for light. 15 14:00-17:20 Exhibitor Showcase - Room 2 15:35-15:55 Coffee Br eak Parallel Sessions Th6 : Nano Biophotonics I- Aula Magna 16:00-16:25 Th6.1(Invited) Ultrapure laser-synthesized nanomaterials for biomedical applications, 1 Andr ei V. Kabashin 1 Aix-Marseille University (AMU), LP3 UMR 7341 CNR S, Campus de Luminy, Case 917, 13288 Marseille (France) This pr esentation over views our r esults on laser -ablative synthesis of ultr apur e nanomater ials for biomedical applications. Running exper iments in vitr o and in vivo, we conclude on “zer o” toxicity of such nanomater ials. We then descr ibe a novel method for cancer ther apy, in which Si nanopar ticles ar e used as sensitizer s of RF-induced hyper ther mia. 16:25-16:50 Th6.2(Invited) Plasmon and plasmon-like nanophotonics for biosensing, 1 Ivo Rendina 1 Institute of Microelectronics and Microsystems, Naples (Italy) 16:50-17:05 Th6.3 Nanophotonic lab-on-a-chip Raman sensors: a sensitivity comparison with confocal Raman Microscope, 1,2 1,2,3 1,2 Ashim Dhakal , P ieter Wuytens , Fr eder ic P eyskens , Ananth 1,2 2,3 1,2 1,2 Subr amanian , Andr e Skir tach , Nicolas Le Thomas , Roel Baets 1 Photonics R esearch Group, Department of Information T echnology, Ghent 2 University-IMEC, Ghent (Belgium), Center for Nano-and Biophotonics (NB3 photonics), Ghent University, Ghent (Belgium), Department of Molecular biotechnology, Ghent University,B-9000 Ghent (Belgium) We compar e the per for mance of sever al nano-photonic waveguide based evanescent Raman sensor s and the confocal micr oscope. While theor etically we expect mor e than 500 times higher signal for 1 cm long waveguides compar ed to the confocal systems, the r esults of our pr eliminar y measur ements indicate at least 25times higher measur ed. 17:05-17:20 Th6.4 Characterization of ZnSe/ZnS QD conjugated with antibody labeling kisspeptins, 1 1 2 1 Anna Dr obintseva , Victor ia P olyakova , Lev Matyushkin , Yulia Kr ylova , 16 2 2 2 Dmitr y Masing , Olga Aleksandr ova , Vyacheslav Moshnikov , Ser gey 3 1 Musikhin , Igor Kvetnoy 1 Ott Institute of Obstetrics Gynecology and R eproductology, Saint Petersburg 2 3 (R ussia), Electrotechnical University, Saint-Petersburg Polytechnical University, Saint-Petersburg (R ussia) To our knowledge, this immunofluor escence assay applied ZnSe/ZnS combined with specific monoclonal antibody detecting kisspeptinsis pr esented for the fir st time. The application in r eal samples with favor able r esults and the highly sensitivity and selectivity fur ther indicate that this QD’s-mAb complex is feasible for kisspeptins detection. Th7 : Sensing and Plasmonic Platforms I- Room 1 16:00-16:25 Th7.1(Invited) Advanced surface plasmon resonance imaging methods for genomic DNA detection, 1 2 3 3 Rober ta D’Agata , Mar zia Calcagno , Giulia Br eveglier i , Monica Bor gatti , 3 1,2 Rober to Gambar i , Giuseppe Spoto 1 Department of Chemical Sciences, University of Catania, Catania (Italy), 2 3 I.N.B.B. Consortium, R oma (Italy), Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara (Italy) Nanopar ticle-enhanced sur face plasmon r esonance imaging methods for P CR-fr ee detection of genomic DNA will be pr esented. The r ole played by the pr oper functionalization of gold nanopar ticles will be also discussed. 16:25-16:50 Th7.2(Invited) Molecular switches for sensing in cells: let's light up the "dark matter" of the genome, 1 1 1 1 Ambr a Giannetti , Bar bar a Adinolfi , Sar a Tombelli , Cosimo Tr ono , 1 Fr ancesco Baldini 1 CNR -IFAC, Sesto Fiorentino (FI) (Italy) The deliver y into cells of molecular switches, can conveniently allow the pr epar ation of small tools to spy on cellular mechanisms with high specificity and sensitivity. The under standing, following, and monitor ing of non-coding RNAs, a sor t of “dar k side” of the genome, could play a fundamental r ole for diagnosis and, even fur ther , for ther apy development. 16:50-17:05 Th7.3 Correlative TERS imaging of B. Subtilis spores, 1 1 2 2 2 Giulia Rusciano , Gianluigi Zito , Rachele Isticato , Teja Sir ec , Ezio Ricca , 1 Antonio Sasso 1 Department of Physics University of Naples Federico II, Naples (Italy), 17 2 Department of Biology, University of Naples Federico II, Naples (Italy) We apply Tip-Enhanced Raman Scatter ing (TERS) for sur face analysis of the Bacillus subtilis spor e, a ver y attr active bio-system for a wide r ange of applications r egulated by the spor e sur face pr oper ties. Our exper imental outcomes r eveal the ar r angement of pr oteins and car bohydr ates on specific spor e sur face r egions, simultaneously r evealed by AFM phase-imaging. 17:05-17:20 Th7.4 Versatile in vivo optogenetic stimulation with microstructured and tapered optical fibers, 1 1 2 1,3 Fer r uccio P isanello , Leonar do Sileo , Ian A Oldenbur g , Mar co P isanello , 4,5 2 1,3 J ohn A Assad , Ber nar do L Sabatini and Massimo De Vittor io 1 Istituto Italiano di T ecnologia-Center for Biomolecular Nanotechnologies, 2 Arnesano, Lecce (Italy), Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA (USA), 3 4 Dip.Ingegneria dell'Innovazione, Università del Salento, Lecce (Italy), Center for Neuroscience and Cognitive Systems@UniT n, Istituto Italiano di 5 T ecnologia, R overeto (Italy), Department of Neurobiology, Harvard Medical School, Boston, MA (USA) We descr ibe the fabr ication and the in vivo implementation of a new and minimally invasive optogenetic device [F. Pisanello et al., Neur on 82, 1245 (2014)] that allows dynamic and selective stimulation of multiple br ain r egions thr ough a single, thin and shar p micr o machined fiber optic. 17:30-17:50 Tr ansfer downtown Flor ence 18:15-19:15 City Tour (1h) 20:00-23:00 Social Dinner at r estaur ant "Lo Spaccio" Fattor ia di Maiano 18 Friday 22nd May 2015 08:00-08:30 Registr ation Plenary III- Aula Magna 08:30-08:55 Fr 1.1(Invited) Applications of Laser Spectroscopy to Meet Challenges in Medicine, 1,2 Katar ina Svanber g 1 Department of Oncology, Lund University Hospital, Lund University, Lund 2 (Sweden), South China Normal University, Guangzhou (China) 08:55-09:20 Fr 1.2(Invited) Tissue optical clearing: new prospects in optical imaging and therapy, 1,2,3 Valer y Tuchin 1 R esearch-Educational Institute of Optics and Biophotonics, National 2 SaratovState University, Saratov (R ussia), Institute of Precise Mechanics and 3 Control of R ussian Academy of Sciences, Saratov (R ussia), Optoelectronics and Measurement T echniques Laboratory, Department of Electrical Engineering, University of Oulu, Oulu (Finland) Achievements of tissue optical clear ing techniques ar e demonstr ated. The specific featur es of optical clear ing of tissues and blood ar e investigated using linear and nonlinear optical techniques in the visible, NIR and ter aher tz. In vitr o, ex vivo, and in vivo studies of a var iety of human and animal tissues ar e pr esented. 09:20-09:45 Fr 1.3(Invited) Coherent hemodynamics spectroscopy for quantitative measurements of cerebral blood flow and autoregulation, 1 1 1 Ser gio Fantini , Angelo Sassar oli , J ana M. Kainer stor fer , and Kr isten T. 1 Tgavalekos 1 Department of Biomedical Engineering, T ufts University, Medford, MA (USA) We pr esent a novel technique, coher ent hemodynamics spectr oscopy (CHS), which is based on fr equency-r esolved measur ements of coher ent cer ebr al hemodynamic oscillations that ar e induced by contr olled per tur bations to the ar ter ial blood pr essur e. The analysis of CHS spectr a with a new hemodynamic model yields quantitative measur ements of local cer ebr al blood flow and autor egulation. 09:45-10:05 Coffee Br eak Parallel Sessions 19 Fr2 : Spectroscopy and Imaging II - Aula Magna 10:05-10:30 Fr 2.1(Invited) Human microcirculation imaging, 1 1 1 1 Mar tin J . Leahy , Roshan Dsouza , Seán O’Gor man , Aedán Br eathnach , 1 1 Har oon Zafar and Hr ebesh Subhash 1 T issue Optics & Microcirculation Imaging Facility, School of Physics, National University of Ireland, Galway, Ireland and National Biophotonics & Imaging Platform (Ireland) 10:30-10:55 Fr 2.2(Invited) Biophotonics and Molecular Imaging: looking at biological function and disease from cells to whole organisms, 1 1 1 Stylianos P sychar akis , Evangelos Liapis , Athanasios Zachar opoulos and 1 Giannis Zachar akis 1 Institute of Electronic Structure and Laser, Foundation for R esearch and T echnology-Hellas, Herak lion Crete (Greece) Moder n tools in biophotonics have r evolutionized biological, pr eclinical and clinical r esear ch, pr oviding new insights into the function of living or ganisms and disease. Technologies such as light-sheet micr oscopy, optical micr o-tomogr aphy, optoacoustics and other s can be used in label-fr ee and tar geted imaging fr om the single cell to the whole or ganism level. 10:55-11:10 Fr 2.3 Mobile platform for online processing of multimodal skinoptical images, 1 1 1 1 Dmitr ijs Bliznuks , Dainis J akovels , Inga Saknite and J anis Spigulis 1 Biophotonics Laboratory, Institute of Atomic Physics and Spectroscopy, University of Latvia, R aina Blvd. 19, LV –1586, R iga (Latvia) Mobile platfor m for multimodal skin assessment has been developed combining diffuse r eflectance, fluor escence spectr al imaging and laser speckle imaging. It consist of handheld, batter y power ed image acquisition module that can be wir elessly connected to mobile phone or laptop and tr ansfer data to online stor age place for fur ther pr ocessing. 11:10-11:25 Fr 2.4 Importance of image processing in digital optical capillaroscopy for early diagnostics of arterial hypertension, 1 2 1 Gur finkel Yu.I. , P r iezzhev A.V. , Kuznetzov M.I. 1 R esearch Clinical Center of JSC “R ussian R ailways”, Moscow (R ussia), 2 Physics Department and International Laser Center of Lomonosov Moscow State University, Moscow (R ussia) Nailfold capillar ies wer e visualized in hyper tensive and pr ehyper tensive patients using digital optical capillar oscopy with a high speed CCD-camer a. Image pr ocessing included stabilization, capillar y contour ing and deter mining the capillar y blood velocity. It allowed 20 for r ecognizing the r emodeling and r ar efaction of capillar ies that ar e impor tant for ear ly diagnostics of ar ter ial hyper tension. 11:25-11:40 Fr 2.5 Benign –atypical nevi discrimination using diffuse reflectance and fluorescence multispectral imaging system, 1 1 1 1 Dainis J akovels , Inga Saknite , Dmitr ijs Bliznuks , J anis Spigulis 1 BiophotonicsLaboratory, Institute of Atomic Physics and Spectroscopy, University of Latvia, R aina Blvd. 19, LV –1586, R iga (Latvia) The multispectr al imaging system Nuance oper ating in spectr al r ange 450-950 nm was adapted for diffuse r eflectance and fluor escence clinical in vivo measur ements of pigmented skin lesions. Pilot study was per for med on 75 volunteer s to test discr imination possibility between benign and atypical nevi 11:40-11:55 Fr 2.6 Development of a time-resolved Diffuse Optical Tomography system based on a single pixel camera, 1 2 3 3 Andr ea Far ina , Mar ta Betcke , Laur a Di Sieno , Alber to Dalla Mor a , Nicolas 4 1,3 1,3 2 Ducr os , Gianluca Valentini , Antonio P iffer i , Simon Ar r idge , Cosimo 3,5 D’Andr ea 1 2 Consiglio Nazionale delle R icerche, IFN, Milano (Italy), Centre for Medical 3 Image Computing, University College London London (UK), Politecnico di 4 Milano, Dipartimento di Fisica Milano (Italy), CR EAT IS, CNR S UMR 5220, INSER M U1044, Universitéde Lyon, INSA Lyon, Villeurbanne (France), 5 Center for Nano Science and T echnology@PoliMi, Istituto Italiano di T ecnologia, Milano (Italy) Diffuse Optical Tomogr aphy (DOT) and Fluor escence Molecular Tomogr aphy (FMT)ar e 3D imaging techniques to quantitatively measur e tissue optical par ameter s. In this wor k a time-r esolved DOT/FMT system based on compr essive sensing appr oach which allows to significantly r educe the data set while pr eser ving the spatial and tempor al capability, is pr esented. Fr3 : Microscopy - Room 2 10:05-10:30 Fr 3.1(Invited) In situ quantitation of collagen fibrils size via absolute measurements of SHG signals, 1 2 1 3 1 2 S. Bancelin , C. Aimé , I. Gusachenko , L. Kowalczuk , G. Latour , T. Cor adin 1 and M.-C. Schanne-Klein 1 École Polytechnique, CNR S, INSER M U696, Laboratoire d’Optique et 2 Biosciences, Palaiseau (France), Sorbonne Universités, UPMC Univ Paris 06, 21 CNR S, Laboratoire de Chimie de la Matière Condensée de Paris, Collège de 3 France, Paris (France), Sorbonne Universités, UPMC Univ Paris 06, INSER M UMR S 872, Centre de R echerche des Cordeliers, Paris (France). We cor r elated SHG and Electr on Micr oscopies to calibr ate SHG signals as a function of collagen fibr il diameter , down to 30 nm. We obser ved a four th power var iation, in agr eement with analytical and numer ical calculations. We applied this calibr ation to abnor mal fibr ils in the Descemet’s membr ane of fr esh r at cor neas. 10:30-10:55 Fr 3.2(Invited) Optical brain imaging, 1 Mascar o, L.A. 1 Lens-University of Florence, Florence (Italy) 10:55-11:10 Fr 3.3 Lens-less microscopy combined with capillary force assembly for systematic particle detection, 1,2 1,2 1,2 3 Olivier Lecar me , Anthony Léonar d , J ulien Cor deir o , Emmanuel P icar d , 1,2 David P eyr ade 1 2 Univ. Grenoble Alpes, F-38000 Grenoble (France), CEA, LET I, LT M-CNR S, 3 MINAT EC Campus, F-38000 Grenoble (France), CEA, INAC-SP2M, SiNaPS, MINAT EC Campus, F-38000 Grenoble (France) We show a method coupling capillar y for ce assembly of colloidal objects and consumer camer a based lens-less micr oscopy for simple and fast detection of micr o-par ticles. As pr oof-of-concept for micr o-biodetection, we demonstr ate the assembly of ~70000 micr obeads in a single par ticle ar r ay and their simultaneous imaging using an ultr a-wide field-of-view lens-less micr oscope. 11:10-11:25 Fr 3.4 Spectral detection of accumulation of a pH-activatable fluorescent probe in dendritic cells, 1,2 3 4 4 1 Zor an Ar sov , Ur ban Švajger , J anez Mr avljak , Stane P ajk , Iztok Ur banč ič , 1,2 4 J anez Štr ancar , Mar ko Ander luh 1 Laboratory of Biophysics, Department of Solid State Physics, Jozef Stefan 2 Institute, Ljubljana (Slovenia), Center of Excellence NAMAST E, Ljubljana 3 (Slovenia), Blood T ransfusion Centre of Slovenia, Ljubljana (Slovenia), 4 Department of Medicinal Chemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana (Slovenia) Inter nalization by antigen-pr esenting dendr itic cells (DCs) was studied with a pH-sensitive pr obe. The pr obe exhibits activation at low pH and an aggr egation-induced spectr al shift. The latter is small, so only a highly spectr ally sensitive fluor escence micr ospectr oscopy (FMS) enabled detection of the pr obe accumulation in low-pH compar tments of DCs 11:25-11:40 Fr 3.5 22 Fluorescence microspectroscopy insight into membrane disintegration driven by titanium dioxide nanoparticles, 1,2 1 1 1,3 Maja Gar vas , Iztok Ur banč ič , Anže Testen , P olona Umek , Miha 1 1,3 1,3 1,4 1,2 Škar abot , Zor an Ar sov , Tilen Koklič , Igor Muševič , J anez Štr ancar 1 2 J. Stefan Institute, Jamova cesta 39, Ljubljana (Slovenia), Jozef Stefan International postgraduate school, Jamova cesta 39, Ljubljana (Slovenia), 3 Center of excellence NAMAST E, Jamova cesta 39, Ljubljana (Slovenia), 4 Faculty of Mathematics and Physics, University of Ljubljana, Jadransk a 19, Ljubljana (Slovenia) By using fluor escence micr ospectr oscopy and Foer ster r esonance ener gy tr ansfer we identify the accumulation of TiO2 nanopar ticles on the membr anes. Aggr egates of the TiO2 nanopar ticles become wr apped by the membr ane lipids and diffuse away, r esulting in a lipid outflow that cr itically destabilizes the lipid bilayer . 12:00-13:00 Poster Session II 13:00-14:00 Lunch Parallel Sessions Fr4 : Sensing and Plasmonic Platforms II - Aula Magna 14:00-14:25 Fr 4.1(Invited) Surface Plasmon Resonance Biosensors to Detect Autoantibodies in Human Plasma – Potentials for Diagnostic Applications, 1 P eter B. Luppa , 1 Institut für Klinische Chemie und Pathobiochemie, Klinik um rechts der Isar der T U München (Germany) 14:25-14:50 Fr 4.2(Invited) Opportunities with light-responsive plasmonic nanomaterials and graphene in therapy and sensing, 1 1 1 1 P aolo Matteini , Fulvio Ratto , Fr ancesca Rossi , Mar ella de Angelis , Mar tina 1 1 1 1 1 Banchelli , Lucia Cavigli , Sonia Centi , Fr ancesca Tatini and Rober to P ini 1 Institute of Applied Physics “Nello Carrara”, National R esearch Council, via Madonna del Piano 10, 50019 Sesto Fiorentino (Italy) P lasmonic nanopar ticles and gr aphene can be used for gener ating photother mal effects and for enhancing the local electr ic field, which in tur n ar e being exploited for a var iety of biomedical applications. We pr esent some light-activated mater ials we have r ecently 23 engineer ed as viable solutions to cr itical issues in ther apy and sensing. 14:50-15:05 Fr 4.3 Towards personalized SNPs screening by SPR biosensing: recent strategies and achievements, 1 1 1 2 1,3 S. Scar ano , S. Mar iani , M.L. Er mini , R. Bar ale , M. Bonini , and M. 1,3 Minunni 1 Department of Chemistry 'Ugo Schiff', University of Florence, Sesto Fiorentino 2 3 (Italy), Department of Biology, University of Pisa, Pisa (Italy), CSGI Consortium, Sesto Fiorentino (Italy) 15:05-15:20 Fr 4.4 “Lab-on-Fiber Technology” for the real time cancer marker detection: developing an innovative local SPR based optical fiber biosensor, 1 1 1 1 Renato Sever ino , Ar mando Ricciar di , Giuseppe Quer o , Benito Car otenuto , 1 2 2 3 Mar co Consales , Alessio Cr escitelli , Emanuela Esposito , Menotti Ruvo , 3 4 4 1 Annamar ia Sandomenico , Anna Bor r iello , Lucia Sansone , Antonello Cutolo , 1 Andr ea Cusano 1 Optoelectronic Division, Dept. of Engineering, University of Sannio, 2 Benevento (Italy), Istituto per la Microelettronica e Microsistemi, National 3 R esearch Council, Napoli (Italy), Istituto di Biostrutture e Bioimmagini, 4 National R esearch Council, Napoli (Italy), Istituto per i Polimeri Compositi e Biomateriali, National R esearch Council, Napoli (Italy) The wor k deals with an innovative Lab-on-Fiber biosensor developed for the r eal time detection of thyr oid car cinomas biomar ker s. Thanks to the pr esence of a metallic nanostr uctur e suppor ting LSP R on the fiber tip, the device is able to detect nanomolar . 15:20-15:35 Fr 4.5 Voltage Sensitivity of Surface Plasmon Resonance for Biological Applications, 1 1 1 2 Sidahmed Abayzeed , Richar d Smith , Kevin Webb , Michael Somekh and 1 Chung See 1 Applied Optics Group, University of Nottingham, Nottingham (UK), 2 Department of Electronic and Information Engineering, T he Hong Kong Polytechnic University, Hung Hom, Kowloon (Hong Kong) Fr5 : Diagnostics and Therapeutics Applications III - Room 2 14:00-14:25 Fr 5.1(Invited) Functional optical coherence tomography on human skin with cellular 24 resolution, 1 2 1 1 Tuan-ShuHo , J eng-Wei Tjiu , Meng-Ting Chien , Dong-Yi Wu , Chia-Kai 1 3 4 4 1 Chang , P inghui S. Yeh , Yu-I Li , Chia-Tung Shun , Sheng-Lung Huang 1 Graduate Institute of Photonics and Optoelectronics, National T aiwan 2 University, T aipei (T aiwan), Department of Dermatology, National T aiwan 3 University Hospital, T aipei (T aiwan), Department of Electronic Engineering, National T aiwan University of Science and T echnology, T aipei (T aiwan), 4 Department and Graduate Institute of Forensic Medicine, National T aiwan University, T aipei (T aiwan) Imaging of cells and tissues with sub-micr on r esolution using optical coher ence tomogr aphy could help unveil functions of living or ganisms and facilitate clinical disease/cancer diagnosis in the ear ly stage. The vector flowing of blood cells in micr o vessels wer e tr aced. Both mor phological r ecognition and par ametr ic analysis will be discussed. 14:25-14:50 Fr 5.2(Invited) Dynamic imaging of human eye accommodation with optical coherence tomography, 1 1,2 1,2 1 Mar co Rugger i , Victor Her nandez , Siobhan Williams , Car olina de Fr eitas , 1 1 1,2 1,2 Flor ence Cabot , Nilufer Yesilir mak , Fabr ice Manns and J ean-Mar ie P ar el , 1 Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of 2 Miami School of Medicine, Miami, FL (USA), Department of Biomedical Engineering, College of Engineering, University of Miami, Coral Gables, FL (USA) We developed optical coher ence tomogr aphy technologies enabling r eal time in vivo imaging and biometr y of the human accommodation optics and mechanics. The instr umentation is used to study the changes leading to pr esbyopia and to acceler ate the development of innovative pr ocedur es aimed at r estor ing accommodation in pr esbyopes and catar act sur ger y patients. 14:50-15:05 Fr 5.3 Antimicrobial effect on Candida albicans by different coupling of wavelengths and colors in photodynamic therapy protocols, 1 2 2 1 Elisabetta Mer igo , Stefania Conti , Tecla Ciociola , Car lo For naini , Luciano 2 1 1 1 P olonelli , Giuseppe Lagor i , Maddalena Manfr edi , P aolo Vescovi 1 Department of Biomedical, Biotechnological and T ranslational Sciences (S.Bi.Bi.T ), University of Parma, Parma (Italy) 15:05-15:20 Fr 5.4 Light-emitting capsule for intra-gastric photodynamic therapy, 1 2 1 2 Giovanni Romano , Feder ico Cubeddu , Bar bar a Or sini , Giuseppe Tor tor a , 3 4 1 1 Monica Monici , Elisabetta Sur r enti , Caloger o Sur r enti , Ar ianna Menciassi 1 and Fr anco Fusi 25 Dept. of Experimental and Clinical Biomedical Sciences “Mario Serio”, 2 University of Florence, Florence (Italy), T he BioR obotics Institute, Scuola 3 Superiore Sant’Anna, Pisa (Italy), ASA Campus Joint Laboratory, ASA R esearch Division, Dept. of Experimental and Clinical Biomedical Sciences 4 “Mario Serio”, University of Florence, Florence (Italy), ASL 10, Florence (Italy) 1 Helicobacter P ylor i is a bacter ium colonizing the stomach antr um, causing sever al gastr ic pathologies and being tr eated with phar macological ther apies. We pr opose the char acter ization of an innovative ther apeutic device –an ingestible luminous capsule –to er adicate Helicobacter P ylor i infection by means of photodynamic ther apyin a minimally invasive way. 15:20-15:35 Fr 5.5 Micro-Raman spectroscopy during orthodontic tooth movement: follow-up of gingival status 1 2 2 2 2 3 C. Camer lingo , F. d’Apuzzo , V. Gr assia , G. P ar ente , L. P er illo , M. Lepor e 1 SPIN-CNR , Istituto Superconduttori, Materiali innovativi e Dispositivi, 2 Pozzuoli (Italy), Dip. Multidisciplinare di Specialità Medico-Chirurgiche e 3 Odontoiatriche, Seconda Università di Napoli, Napoli (Italy), Dip. di Medicina Sperimentale, Seconda Università di Napoli, Napoli (Italy) The potentiality of Micr o-Raman spectr oscopy to evaluate GCF composition changes gener ated in the per iodontium by or thodontic for ces was assessed. A suitable numer ical tr eatment based on wavelet algor ithms has been used for spectr al data. The pr eliminar y r esults showed an incr ease of car otene in GCF dur ing the or thodontic tooth movement . 15:35-15:55 Coffee Br eak Parallel Sessions Fr6 : Food - Aula Magna 16:00-16:25 Fr 6.1(Invited) Smart sensors for food safety: opportunities and challenges, 1 Chiar a Dall’Asta 1 Department of Food Science, University of Parma, Parma (Italy) Food safety is mainly aimed at the pr evention of food-r elated outbr eaks. Although, instr umental pr otocols ar e still gold standar ds, ther e is a need for complementar y techniques in the field of r apid scr eening. This communication focuses on the major advantages and challanges associated with the use of optical sensor s in food safety. 16:25-16:40 Fr 6.2 Si-based Monolithic Poylchromatic Young Interferometeras an Enabling 26 Tool for Point-of-Need Food Safety Determinations, 1 2 2 Konstantinos Misiakos , P anagiota P etr ou , Sotir ios Kakabakos , Alexandr os 1 3 3 4 Salapatas , Athanasios Botsialas , Ioannis Raptis , Iliani Kylintir ea , 4 5 6 Tr iantafyllos Sar afidis , Antonis Lambidonis , Anastasios Var ouxis , Eleni 1 Makar ona 1 Institute of Nanoscience and Nanotechnology, NCSR “Demok ritos”, Athens 2 (Greece), Institute of Nuclear and R adiological Sciences &Energy, Safety and 3 Environment, NCSR “Demok ritos”, Athens (Greece), T hetaMetrisis S.A., 4 5 Egaleo; H+S T echnology Solutions S.A., Ellinik o (Greece), Food Allergens 6 Laboratory, R ethymno (Greece), Provirom Ltd, Elefsina (Greece) We pr esent an optoelectr onic platfor m designed for the multi-analyte, label-fr ee, r eal-time detection of pesticides in dr inking water and agr icultur al pr oducts. The platfor m, exploiting br oad-band Young inter fer ometr y, specially-designed immunosensing/functionalization str ategies and a compact and user -fr iendly r eader is cur r ently used for the deter mination of pesticide r esidues in dr inking water samples. 16:40.16:55 Fr 6.3 Nondestructive assessment of apple optical properties during growth by time-resolved reflectance spectroscopy in the orchard, 1 2 2 2 Alessandr oTor r icelli , Dominique Fleur y , J eanne Giesser , Reynald P asche , 3 3 4 J ana Kaethner , Manuela Zude , Lor enzo Spinelli 1 2 Dipartimento di Fisica, Politecnico di Milano, Milan (Italy), Hes so, 3 Changins, Nyon (Switzerland), Leibniz Institute for Agricultural Engineering 4 Potsdam-Bornim, Potsdam (Germany), Istituto di Fotonica e Nanotecnologie, Consiglio Nazionale per le R icerche, Milan (Italy) We r epor t on the fir st application of time-r esolved r eflectance spectr oscopy in the or char ds for the nondestr uctive assessment of apple optical pr oper ties dur ing gr owth. A por table dual-wavelength (650 nm, 780 nm) system was developed and used to assess the absor ption coefficient and the r educed scatter ing coefficient of apples dur ing gr owth. 16:55-17:10 Fr 6.4 Multilayer integrated structure for selective detection of Ochratoxin A, 1 1 1 2 3 4 D. Caputo , E. P ar isi , M. Car pentier o , F. P avanello , M. Tucci , A. Nascetti , 1 G. de Cesar e 1 2 DIET University of R ome “La Sapienza” R ome (Italy), AUT OMAT ION s.r.l. 3 Abbiategrasso, Milano (Italy), ENEA, R esearch Center Casaccia, R ome 4 (Italy), DIAEE University of R ome “La Sapienza” R ome (Italy) This wor k pr esents, for the fir st time, the integr ation on the same glass substr ate of amor phous silicon photosensor s and of a long pass thin film filter , in or der to achieve a mor e compact and efficient system to detect Ochr atoxin A, a highly toxic mycotoxin pr esent in widespr ead food commodities. 27 17:10-17:25 Fr 6.5 Non-destructive fluorescence sensing for applications in precision viticulture, 1 2 1 Lor enza Tuccio , Gr aziana Gr assini , Giovanni Agati 1 Istituto di Fisica Applicata “Nello Carrara” – Consiglio Nazionale delle 2 R icerche, Sesto Fiorentino (Italy), Centro Analisi C.A.I.M.,Via del T urismo 196, 58022 Follonica (Italy) A por table fluor escence sensor was used to assess in a sustainable, r apid and non destr uctive way tar get molecules in winegr ape (Vitis vinifer a L.) which mar kedly change dur ing fr uit matur ity and plant str ess conditions. These infor mation pr ovided in situ ar e useful in pr ecision viticultur e to suppor t pr oducer decisions and impr ove the wine quality. Fr7 : Nano Biophotonics II - Room 2 16:00-16:25 Fr 7.1(Invited) Magnetite Nanoparticles for Optical Diagnostics and Laser Regeneration of Cartilage, 1 1 1 Emil Sobol , Alexander Omelchenko , YuliaSoshnikova , 1 Institute on Laser & Information T echnologies, R ussian Academy of Sciences, T roitsk (R ussia) 16:25-16:40 Fr 7.2 Plasmon-resonant nanostars with variable sizes as contrast agents for optical coherence tomography and confocal microscopy, 1,2 3 3 1,2 Olga Bibikova , Andr ew Fales , Hsiangkuo Yuan , Alexey P opov , Alexander 1,2 1 4,5 6 Bykov , Matti Kinnunen , Vladimir Bogatyr ev , Kr isztian Kor das , Tuan Vo3 1,2,7 Dinh , Valer y Tuchin 1 Optoelectronics and Measurement T echniques Laboratory, Department of Electrical Engineering, Faculty of Information T echnology and Electrical 2 Engineering, University of Oulu, Oulu (Finland), R esearch-Educational Institute of Optics and Biophotonics, Saratov State University, Saratov 3 (R ussia), Fitzpatrick Institute for Photonics, Departments of Biomedical 4 Engineering and Chemistry, Duk e University, Durham, NC (USA), Institute of Biochemistry and Physiology of Plants and Microorganisms, R ussian Academy 5 of Sciences, Saratov (R ussia), Department of Biophysics, Faculty of Nonlinear 6 Processes, Saratov State University, Saratov (R ussia), Microelectronics and Materials Physics Laboratories, Department of Electrical Engineering, Faculty of Information T echnology and Electrical Engineering, University of Oulu, 28 7 Oulu (Finland), Institute of Precise Mechanics and Control, R ussian Academy of Sciences, Saratov (R ussia) Gold nanostar s with var iable sizes wer e synthesized and optically char acter ized by a spectr ophotometer system with integr ating spher es. The high scatter ing contr ibution enables usage of nanostar s as contr ast agents in optical coher ence tomogr aphy for bioimaging and in laser confocal micr oscopy for r eal-time obser vation of NSts localisation inside living cells. 16:40.16:55 Fr 7.3 Diatomite nanoparticles as potential drug delivery systems, 1,4 2 3 2 3 M. Ter r acciano , A. Lamber ti , H.A.Santos , N.M.Mar tucci , M.A.Shahbazi , 3 2 1 1 1 A.Cor r eir a I.Ruggier o , I. Rendina , L. De Stefano , I.Rea 1 Institute for Microelectronics and Microsystems, National R esearch Council, 2 Naples (Italy), Department of Molecular Medicine and Medical Biotechnology, 3 University of Naples Federico II, Naples (Italy), Division of Pharmaceutical Chemistry and T echnology, Faculty of Pharmacy, University of Helsink i 4 (Finland), Department of Pharmacy, University of Naples Federico II, Naples (Italy) The physical and chemical pr oper ties of diatomite, the r elatively low cost and abundance in natur e have attr acted a lar ge var iety of industr ial applications such as food pr oduction, water extr acting agent, pr oduction of cosmetic and phar maceutics; in par ticular , the chemical iner tness, ther mal stability, high sur face ar ea, non-toxicity and biocompatibility make diatomite ideal mater ial for the pr epar ation of dr ug deliver y nanocar r ier s. 16:55-17:10 Fr 7.4 Raman Imaging for the Intracellular Label-Free detection and study of Drug Nanocarriers and Graphene nanoparticles, 1 2 1 2,3 Renzo Vanna , Feder ica Valentini , Car lo Mor asso , Aldr ei Boar etto , Laur a 4 4 1 1 1 P andolfi , P aolo Ver der io , Silvia P icciolini , Alice Gualer zi , Mar zia Bedoni , 4 1 Davide P r osper i , Fur io Gr amatica 1 Laboratory of Nanomedicine and Clinical Biophotonics (LABION), 2 Fondazione Don Carlo Gnocchi ONLUS, Milan (Italy), Dipartimento di 3 Scienze e T ecnologie Chimiche, R ome (Italy), CAPES Foundation, Ministry of 4 Education of Brazil Brasilia (Brazil), Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Milano (Italy) Nanopar ticles ar e emer ging as a new platfor m for cancer ther apy, but their intr acellular char acter ization is mostly based on fluor escent labelling. Her e we show how the use of Raman spectr oscopy per mits the label-fr ee localization and the chemical char acter ization of dr ug-loaded nanopar ticles and gr aphene nanopar ticles at intr acellular level. 17:10-17:25 Fr 7.5 Strategies for gold nanorods targeting of tumors for optical hyperthermia, 29 1 1 1 2 2 Sonia Centi , Fulvio Ratto , Fr ancesca Tatini , Ida Landini , Stefania Nobili , 3 3 3 3 Ewa Witor t , Giovanni Romano , Fr anco Fusi , Ser gio Capaccioli , Enr ico 3 1 Mini , Rober to P ini 1 Institute of Applied Physics, National R esearch Council of Italy, Sesto F.no 2 (Italy), Department of Health Science, University of Florence, Firenze (Italy), 3 Department of Experimental Biomedical and Clinical Science, University of Florence, Firenze (Italy) Gold nanor ods (GNRs) ar e optimal contr ast agents for photoacustic imaging and photother mal ablation of cancer . Selective tar geting of cancer cells with these contr ast agents may r ely on complementar y biochemical and biological str ategies, including the use of specific pr obes or the exploitation of cellular vehicles. Differ ent appr oaches for active deliver y ar e r epor ted. 30 Poster Session I Thursday 21st May 2015, 12:10-13:10 P1 .1 . Skin neoplasm diagnostics using combined spectral method in visible and near infrared regions 1 1 1 1 Valer y Zakhar ov , Ivan Br atchenko , Dmitr y Ar temyev , Oleg Myakinin , Yulia Khr istofor ova 1, Mar ia Vr akova 1 1 Samara State Aerospace University, Samara, R ussia P1 .2 . Delivering a photosensitizer to the right place - what matters Ludmil Benov1, 1 Department of Biochemistry, Faculty of Medicine, Kuwait University, Kuwait P1 .3 . Photophysical properties of free and metallated meso-substituted Tetrabenzotriazaporphyrin and Isoindole-boron dipyrromethene derivatives from density functional theoretical investigation Br una C. De Simone1, Mar ta E. Alber to1, Glor ia Mazzone1, Tiziana Mar ino1, Nino Russo1 1 Dipartimento di Chimica e T ecnologie Chimiche, Università della Calabria, R ende, Italy P1 .4 . Optical spectroscopy in photodynamic therapy for superficial skin malignancies and actinic keratosis E. Dr akaki1, I. Stefanaki2, C. Dessinioti2, I.A. Sianoudis3, M. Makr opoulou 1, A.A. Ser afetinides1, E. Chr istofidou 2, A.J . Str atigos2, A.D. Katsambas2, Ch. Antoniou 2 1 National T echnical University of Athens, Dept of Physics, Athens, Greece, 2University of Athens, Dept of Dermatology, Hospital A. Syggros, Athens, Greece, 3T echnological Educational Institute (T EI) of Athens, Dept of Optics & Optometry, Athens, Greece P1 .5 . Er:YAG Laser in orthodontic brackets bonding: “ex vivo” study Car lo For naini1,2, Michele Sozzi1, J ean-P aul Rocca 2, Stefano Seller i1 and Anna Cucinotta 1 1 Information Engineering Department, University of Parma, Parma, Italy, 2R estorative Dentistry and Endodontics Department, Faculty of Dentistry, University of Nice-Sophia Antipolis, Nice Cedex 4, France P1 .6 . Laser and light on dental composite polymerization comparison: “in vitro” study Car lo For naini1,2, Giuseppe Lagor i1, Michele Sozzi2, Elisabetta Mer igo1, Stefano Seller i2 And Annamar ia Cucinotta 2 1 Oral Medicine and Laser-assisted Surgery Unit, University of Parma, Parma, Italy, 2 Information Engineering Department, University of Parma, Parma, Italy P1 .7 . Performing of the Polarimetric Imaging Diagnosis of Ex-vivo Uterine Cervical 31 Cancer Huda Haddad 1 1 Laboratoire de Physique des Interfaces et des Couches Minces, CNR S UMR 7647, Ecole polytechnique 91128 Palaiseau, France P1 .8 . Necrosis as a consequence of PKC silencing after hypericin photoactivation in U8 7 -MG cells Zuzana Nadova 1, J ar oslava J oniova 1, Matus Misuth 1, Michaela Fer encakova 1, Fr anck Sur eau 3 and P avol Miskovsky1,2 1 Dept. of Biophysics, P.J. Safarik University, Kosice, Slovak ia, 2Center for 3 Interdisciplinary Biosciences P.J. Safarik University, Kosice, Slovak ia, CNR S / UPMC Univ Paris 06, Laboratoire Jean Perrin LJP, Paris, France P1 .9 . Cell Viability in the Endothelium of Porcine Cornea exposed to Ultrashort Laser Pulses Syed Asad Hussain 1, Fatima Alahyane1, Car oline Cr otti1, Zacar ia Essaïdi1, Laur a Kowalczuk 1, Mar ie-Clair e Schanne-Klein 2, Kar sten P lamann 1 1 Laboratoire d’optique appliquée, ENST A ParisT ech - École polytechnique - CNR S Palaiseau cedex, France. 2Laboratoire d'optique et biosciences, École polytechnique – CNR S Palaiseau cedex, France. P1 .1 0 . Investigation of deep stroma by confocal microscopy F. Rossi1, F. Tatini1, A. Canovetti2, A. Malandr ini2, I. Lenzetti2, L. Menabuoni2, P . Valente3, L. Buzzonetti3, R. P ini1 1 Institute of Applied Physics IFAC-CNR , Florence, Italy, 2Nuovo Ospedale Santo Stefano, Prato, Italy, 3Bambino Gesù IR CCS Children’s Hospital, Fiumicino, Italy P1 .1 1 . Effects of probe placement on tissue oxygenation levels during reflectance measurements for different types of tissues in a clinical setting Sur esh Anand 1 and Sujatha Nar ayanan Unni1 1 Biomedical Engineering Group, Department of Applied Mechanics, Indian Institute of T echnology Madras, Chennai-600 036, India P1 .1 2 . Random access microscopy to unravel the spatio-temporal relationship between T-tubular electrical activity and Ca2 + release in heart failure C. Cr ocini1, R. Coppini2, C. Fer r antini2, P . Yan 3, L. Loew3, C. Tesi2, C. P oggesi2, E. Cer bai2, F.S. P avone1,4,5, L. Sacconi1,5 1 European Laboratory for Non-Linear Spectroscopy (LENS), Florence, Italy; 2University of Florence, Interuniversity Center of Molecular Medicine and Applied Biophysics CIMMBA, Florence, Italy, 3R . D. Berlin Center for Cell Analysis and Modeling, University of Connecticut Health Center, Connecticut, United States of America, 4 Department of Physics and Astronomy, University of Florence, Sesto Fiorentino, Italy, 5 National Institute of Optics INO-CNR , Florence, Italy P1 .1 3 . TDE: a new versatile clearing agent for multi modal brain imaging 32 Ir ene Costantini1, Antonino P aolo Di Giovanna 1, Anna Letizia Allegr a Mascar o1, Ludovico Silvestr i1, Mar ie Car oline Müllenbr oich 1, Leonar do Sacconi1,2, Fr ancesco Saver io P avone1,2,3 1 European Laboratory for Non-linear Spectroscopy, University of Florence, Sesto Fiorentino, Italy, 2National Institute of Optics INO-CNR , Florence, Italy, 3Department of Physics and Astronomy, University of Florence, Sesto Fiorentino, Italy P1 .1 4 . Combined multiphoton and optical coherence microscopy Dominik Mar ti1, Mathias Chr istensen 1, P eter E. Ander sen 1 1 T echnical University of Denmark , R osk ilde, Denmark P1 .1 5 . Optical methods for research of teeth dentin with chronic fibrous pulpitis Elena Timchenko1, P avel Timchenko1, Lar isa Zher deva (Taskina) 1, Lar isa Volova 1 1 Samara State Aerospace University (SSAU), R ussia P1 .1 6 . Optical methods of collagen and hydroxyapatite change monitoring in the process of bone tissue demineralization Elena Timchenko1, P avel Timchenko1, Lar isa Zher deva (Taskina) 1, Lar isa Volova 1, J ulia P onomar eva 1 1 Samara State Aerospace University (SSAU), R ussia P1 .1 7 . Optical methods of hydrogen degassing monitoring in the city areas E.V. Timchenko1, P .E. Timchenko1, L.A. Taskina 1, N.V. Tr egub 1, E.A. Seleznyeva 1, V.N. Yakovlev1 1 Samara State Aerospace University (SSAU), R ussia P1 .1 8 . Optical methods of aquatic plants under the influence of pollutants monitoring E.V. Timchenko1, P .E. Timchenko1, L.A. Taskina 1, N.V. Tr egub 1, A.A. Asadova 1 1 Samara State Aerospace University (SSAU), R ussia P1 .1 9 . FLIM-FRET analysis using Ca2 + sensors in HeLa cells Ilar ia For tunati1, Camilla Fer r ante1, Renato Bozio1, Elisa Gr eotti2,3, Tullio P ozzan 2,3,4 1 Chemical Science Dept., University of Padova and INST M, Padova, Italy, 2Biomedical Sciences Dept., University of Padova, Padova, Italy, 3Italian National R esearch Council (CNR ), Padova, Italy. 4Venetian Institute of Molecular Medicine, Padova, Italy P1 .2 0 . BSA adsorption on gold nanoparticles investigated under static and flow conditions Camilla Fer r ante1, Ilar ia For tunati1, Ver ena Weber 1 1 Dept. di Scienze Chimiche, Università di Padova, Padova, Italy P1 .2 1 . Physiology-First Development for Resonant Reflection Spectroscopy of Skeletal Muscle Sarcomeres Kevin W. Young1,2, Stojan Radic1, Evgeny Myslivets1, Shawn M. O’Connor 1, Richar d L. Lieber 1,2,3 1 2 University of California San Diego, La Jolla, CA, USA , VA San Diego Healthcare System, San Diego, CA, USA , 3R ehabilitation Institute of Chicago, Chicago, IL, USA 33 P1 .2 2 . Sensing platform for the detection of tumor markers P r askoviya Boltovets1, Ganna Ger aschenko2, Ludmila Str okovska 2, Maya Bobr ovska 2, Ser giy Kr avchenko1, Bor is Snopok 1, Vladimir Kashuba 2 1 Institute of Semiconductor Physics NAS of Uk raine, Kyiv, 2Institute of Molecular Biology and Genetics NAS of Uk raine, Kyiv P1 .2 3 . New generation superconducting optical converter with single photon resolution in near and mid IR range M.A. Tar khov1, B.A. Gur ovich 1, K.E. P r ikhodko1, E.A. Kuleshova 1, V.L. Stolyar ov1, E.D. Olshansky1, B.V. Gonchar ov1, D.A. Gonchar ova 1, A.G. Domantovsky1, L.V.Kutuzov1, 1 P .P .An 1 National R esearch Centre “Kurchatov Institute”, Moscow, R ussia P1 .2 4 . Detection of viral DNA by isothermal NASBA amplification and chemiluminescence gene probe hybridization assay in a microfluidic cartridge with integrated array of amorphous silicon photosensors Mar a Mir asoli1, Fr ancesca Bonvicini2, Augusto Nascetti3, Giampier o De Cesar e4, Mar tina Zangher i1, Domenico Caputo4, Gior gio Gallinella 2, Aldo Roda 1 1 Department of Chemistry, Alma Mater Studiorum, University of Bologna, Bologna, Italy, 2Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Bologna, Italy, 3Department of Astronautics, Electrical and Energy Engineering, Sapienza University of R ome, R ome, Italy, 4Department of Information, Electronic and T elecommunication Engineering, Sapienza University of R ome, R ome, Italy P1 .2 5 . Transmission and Reflection SPR Disposable Fibre Probes for Bio -chemical Sensing P apiya Dhar a 1,2, Massimo Oliver o1, Alber to Vallan 1, Guido P er r one1 1 Politecnico di T orino - Dept. of Electronics and T elecommunications, T orino, Italy, 2 Dept. of Applied Physics,Indian School of Mines, Dhanbad, India P1 .2 6 . Mobile Laser Radar Platform for Environmental Monitoring Guangyu Zhao1, Ming Lian 1, Zheng Duan 1, Yiyun Li1, Zhiming Zhu 1, Liang Mei1, and Sune Svanber g1,2 1 COER , South China Normal University, Guangzhou, China , 2Lund Laser Centre, Lund University, Sweden P1 .2 7 . Optical Birefringence Sensor for Fluidic Concentration Measurements Ruey-Ching Twu 1 and Guan-Min Chen 1 1 Department of Electro-Optical Engineering, Southern T aiwan University of Science and T echnology, T ainan, T aiwan P1 .2 8 . Inducing cells rotation in a microfluidic device by hydrodynamic forces 1 1 1 1 2 S. Tor ino , M. Iodice , I. Rendina , G. Coppola , E. Schonbr un 1 Institute for Microelectronics and Microsystems, National R esearch Council, Naples, 34 Italy, 2R owland Institute at Harvard, Harvard University, Cambridge MA, USA P1 .2 9 . Micro Rings – a new way of optical sensing, M. Kleiner t, C. Zawadzki, N. Keil, W. Schlaak 1 1 Fraunhofer Heinrich-Hertz-Institute HHI, Berlin, Germany P1 .3 0 . Nanodome coins for intracellular surface-enhanced Raman spectroscopy P ieter Wuytens1,2,3, Winnok De Vosb 4, Andr e Skir tach 2,3, Roel Baetsa 3, 1 P hotonics Resear ch Gr oup, Ghent Univer sity-imec, Ghent, Belgium, 2Depar tment of Molecular Biotechnology, Ghent Univer sity, Belgium, 3Center for Nano- and Biophotonics, Ghent Univer sity, Belgium, 4Dept. Veter inar y Sciences, Univer sity of Antwer p, Antwer p, Belgium 35 Poster Session II Friday 22nd May 2015, 12:00-13:00 P2 .1 . In situ assessment of quality-related compounds in fruits by using fluorescence sensors Elisa Fier ini1, Lisa Banelli1, Damiano Remor ini2, P atr izia P inelli1, Annalisa Romani1, Giovanni Agati3 1 Dipartimento di Statistica, Informatica, Applicazioni-DiSIA, Università di Firenze, Firenze, Italy, 2Dipartimento di Scienze Agrarie, Alimentari e Agro-ambientali (DiSAAAa) -Università di Pisa, Pisa, Italy, 3Istituto di Fisica Applicata “Nello Carrara” –CNR , Sesto Fiorentino (Firenze) Italy P2 .2 . Fruit ripening studied by optical spectroscopic techniques J ing Huang1, Hao Zhang1, Tianqi Li1, Huiying Lin 1, Guangyu Zhao1, Liang Mei2, Sune Svanber g1,2 and Katar ina Svanber g1,2 1 COER , South China Normal University, Guangzhou, China, 2Lund Laser Centre, Lund University, Sweden P2 .3 . Optical Remote Sensing of Flying Insects Mikkel Br ydegaar d 1, Tianqi Li2, Shiming Zhu 2, Guangyu Zhao2 and Sune Svanber g1,2 1 Lund Laser Centre, Lund University, Sweden, 2COER , South China Normal University, Guangzhou, China P2 .4 . Array of differential photodiodes for lab-on-chip applications M. Car pentier o1, E. P ar isi1, G. P etr ucci1, D. Caputo1, A. Nascetti1, G. de Cesar e1 1 DIET University of R ome “La Sapienza”, R ome, Italy, 2DIAEE University of R ome “La Sapienza” R ome, Italy P2 .5 . Dispersion Compensation of 4 0 Gb/s Data by Phase Conjugation in Slow Light Engineered Chalcogenide and Silicon Photonic Crystal Waveguides Far shid Koohi-Kamali1, Majid Ebnali-Heidar i1, and Mohammad Kazem Mor avvej-Far shi2 1 Shahrek ord University Shahrek ord 8818634141, Iran, 2Advanced Devices Simulation Laboratory, Faculty of Electrical and Computer Engineering, T arbiat Modares University T ehran 14117-13116, Iran P2 .6 . Optical Microfibre Sensor incorporating Alloy Nanoparticles 1 Lin Bo , Yuliya Semenova 1, P engfei Wang1, J oão Conde2, Fur ong Tian 3, Benjamin Schazmann 4, and Ger ald Far r ell1 1 Photonics R esearch Centre, Dublin Institute of T echnology, Dublin, Ireland; 2Institute for Medical Engineering and Science, Harvard-MIT Division for Health Sciences and T echnology, Cambridge, Massachusetts, USA, 3Focas R esearch Institute, Dublin Institute 36 of T echnology, Dublin, Ireland, 4School of Chemical and Pharmaceutical Sciences, Dublin Institute of T echnology, Dublin, Ireland P2 .7 . Reflection Type Long Period Fiber Grating Biosensor for real time Thyroglobulin detection as differentiated thyroid cancer biomarker: The “Smart Health” Project Renato Sever ino1, Giuseppe Quer o1, P atr izio Vaiano1, Alessandr a Boniello1, Mar co Consales1, Menotti Ruvo2, Annamar ia Sandomenico2, Anna Bor r iello3, Simona Zuppolini3, Laur a Diodato3, Antonello Cutolo1 and Andr ea Cusano1 1 Optoelectronic Division, Dept. of Engineering, University of Sannio, Benevento, Italy , 2 3 Istituto di Biostrutture e Bioimmagini, National R esearch Council, Napoli Italy; Istituto per i Polimeri Compositi e Biomateriali, National R esearch Council, Portici Italy P2 .8 . All optical ferrule-top sensor for indentation measurements of very soft biological tissues N. Antonovaite1 , S.V. Beekmans1, H. van Hoor n 1, L. Beex-Osbor n 2, E.M. Hol2, W.J . Wadman 2, D. Iannuzzi1 1 Department of Physics and Astronomy and LaserLaB, VU Amsterdam, T he Netherlands, 2 Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, T he Netherlands P2 .9 . Development of a Fiber-top Controlled Adaptable Stiffness Needle Beekmans SV1, van den Dobbelsteen J 2, Iannuzzi D1 1 Biophotonics and Medical Imaging, VU Laserlab, VU University Amsterdam, T he Netherlands, 2Department of BioMechanical Engineering, University of T echnology, Delft P2 .1 0 . Graphene oxide/ silver nanocube composites for SERS detection of biomolecules Mar tina Banchelli1, P aolo Matteini1, Gabr iella Caminati2, Br uno Tir ibilli3, Rober to P ini1 1 Institute of Applied Physics IFAC-CNR , Florence, Italy. 2Department of Chemistry and CSGI, University of Florence, Sesto Fiorentino, Italy. 3Institute for Complex Systems CNR , Florence (Italy) P2 .1 1 . Multiplexed SOI Ring Resonators for Real-Time Protein Detection Manuel Mendez-Astudillo1,2, Danny Volkman 1, Matthias J äger 1 1 T echnische Universität Berlin, Gemany, 2 Waseda University, Shinjuk u, T ok yo, Japan P2 .1 2 . Microstructured waveguides for express analysis of water, coffee, tea and wine and spirit Anastasiya A. Zanishevskaya 1,2, Andr ey A. Shuvalov1,2, Yulia S. Skibina 1,2, Valer y V. Tuchin 2,3,4 1 SPE Nanostructured Glass T echnology, Saratov, R ussia, 2R esearch-Educational Institute of Optics and Biophotonics, Saratov State University, Saratov, R ussia; 3Institute 4 of Precise Mechanics and Control R AS, Saratov, R ussia, Laboratory of Biophotonics, T omsk State University, T omsk , R ussia 37 P2 .1 3 . Gold&Nanodiamond: new multifunctional tools for SERS application Giacomo Reina 1, Ser ena Lenti1, Emanuela Tambur r i1, Stefano Gay1, Angelo Gismondi2, Mar ia Letizia Ter r anova 1, Silvia Or landucci1 1 Dip. di Scienze e T ecnologie Chimiche, Università di R oma T or Vergata, R oma, Italy, 2 Dip. di Biologia, Università di R oma T or Vergata, R oma, Italy P2 .1 4 . Magneto-Optical Localised-SPR a novel sensing platform to characterize new nanostructured materials for sensing Mar ia Gr azia Maner a 1, Rober to Rella 1 1 CNR IMM Lecce, Italy P2 .1 5 . POCT immunosuppressants monitoring by a novel optical biochip B. Adinolfi1, C. Ber r ettoni1,2, S. Ber neschi1, R. Ber nini3, K. Cr emer 4, C. Gar tner 4, A. Giannetti1, I.A. Gr imaldi3, G. P er sichetti3, G. Testa 3, S. Tombelli1, C. Tr ono1, F. Baldini1 1 Istituto di Fisica Applicata Nello Carrara, Sesto Fiorentino, Italy; 2Dept. Information Engineering and Mathematics, Siena University, Siena, Italy; 3Institute for Electromagnetic Sensing of the Environment, CNR , Napoli, Italy; 4 microfluidic ChipShop GmnH, Jena, Germany P2 .1 6 . Towards feasible label-free biosensing by means of long period fibre gratings: performance assessment using IgG/anti-IgG model assay F. Chiavaioli1, C. Tr ono1, P . Biswas2, S. Bandyopadhyay2, N. Basumallick 2, K. Dasgupta 2, A. Giannetti1, S. Tombelli1, S. J ana 2, S. Ber a 2, A. Mallick 2, F. Baldini1 1 CNR -IFAC, Institute of Applied Physics “Nello Carrara”, Sesto Fiorentino (FI), Italy; 2 CSIR -CGCR I, Central Glass and Ceramic R esearch Institute, Kolk ata, India P2 .1 7 . Phosphate glasses and optical fibres for bio-photonic application Edoar do Ceci Ginistr elli1, Diego P ugliese1, Simone Ber neschi2, Nadia Boetti1, Gior gia Novajr a 1, Chiar a Vitale-Br ovar one1, J or is Lousteau 3, Fr ancesco Baldini2, Daniel Milanese1 1 Politecnico di T orino, T orino, Italy, 2Istituto di Fisica Applicata “Nello Carrara”, Firenze, Italy, 3Optoelectronics R esearch Centre, University of Southampton, Southampton, UK P2 .1 8 . Preparation and characterization of 3 D hyaluronic scaffolds with controlled optical properties for biomedical applications M. Lepor e1, M. P or taccio1, I. Delfino2, A. La Gatta 1, A. D’Agostino1, E. Izzo1, C. Schir aldi1 1 Dipartimento. di Medicina Sperimentale, Seconda Università di Napoli, Napoli, Italy, 2 Dipartimento di Scienze Ecologiche e Biologiche, Università della T uscia, Viterbo, Italy P2 .1 9 . Investigation of fluorescence properties of cationic (phenothiazinyl)vinylpyridinium dye attached electrostatically to multilayered polyelectrolyte-coated gold nanorods Ana-Mar ia Gabudean 1, Luiza Gaina 2, Luminita Silaghi-Dumitr escu 2, Simion Astilean 1 1 Nanobiophotonics and Laser Microspectroscopy Center, Interdisciplinary R esearch Institute in Bio-Nano-Sciences and Faculty of Physics, Babes-Bolyai University,Cluj38 Napoca, R omania; 2Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University, Cluj-Napoca, R omania P2 .2 0 . Gelatin-assisted synthesis of gold nanoparticles and investigation of their biocompatibility and osteogenic effect on Osteoblast cells Sor ina Suar asan 1, Monica Focsan 1, Olga Sor itau 2, Dana Maniu 1, Simion Astilean 1 1 Nanobiophotonics and Laser Microspectroscopy Center, Interdisciplinary R esearch Institute on Bio-Nano-Sciences and Faculty of Physics, Babes-Bolyai University, ClujNapoca, R omania, 2R adiobiology and T umor Biology Laboratory, Oncological Institute “Prof Dr. Ion Chricuţă”, Cluj-Napoca, Romania P2 .2 1 . Sensitivity Improved Plasmonic Platform for Specific Biomarkers Detection Monica Focsan 1, Andr eea Campu 1, Cosmin Leor dean 1, Monica P otar a 1, Ana Gabudean 1, Dana Maniu 1, Simion Astilean 1 1 Interdisciplinary R esearch Institute in Bio-Nano-Sciences, Faculty of Physics, BabesBolyai University, Cluj-Napoca, R omania P2 .2 2 . 5 -Fluorouracil loaded silver nanotriangles as highly effective agents for imageguided therapy of pancreatic cancer cells Monica P otar a 1, Timea Simon 1, Emilia Licar ete2, Simion Astilean 1 1 Nanobiophotonics and Laser Microspectroscopy Center, Interdisciplinary R esearch Institute in Bio-Nano-Sciences and Faculty of Physics, Babes-Bolyai University, ClujNapoca, R omania; 2Molecular Biology Center, Interdisciplinary R esearch Institute in Bio-Nano-Sciences and Faculty of Biology, Babes-Bolyai University, Cluj-Napoca, R omania P2 .2 3 . Fabrication of Pluronic Encapsulated Porphyrin - Gold Nanoparticles and Investigation of their Potential in Photodynamic Therapy Timea Simon 1, Ana-Mar ia Gabudean 1, Emilia Licar ete2, Luiza Gaina 3, Luminita SilaghiDumitr escu 3, Simion Astilean 1 1 Nanobiophotonics and Laser Microspectroscopy Center, Interdisciplinary R esearch Institute in Bio-Nano-Sciences and Faculty of Physics, Babes-Bolyai University, ClujNapoca; 2Molecular Biology Center, Interdisciplinary R esearch Institute in Bio-NanoSciences and 3Faculty of Biology, Babes-Bolyai University, Cluj-Napoca, R omaniaFaculty of Chemistry and Chemical Engineering, Babes-Bolyai University,ClujNapoca, R omania P2 .2 4 . Spatio-temporal thermal processes induced by pulsed laser irradiation of medium doped by nanoparticles Alexander N. Yakunin 1,2, Yur i A. Avetisyan 1,2, Alexey A. Bykov2 and Valer y V. Tuchin 2 1 R ussian Academy of Sciences, Institute of Precise Mechanics and Control, S aratov R ussia; 2N.G. Chernyshevsk y Saratov State University, Saratov R ussia P2 .2 5 . Optical measurements of glycerol diffusion in skin tissue Ali J aafar Sadeq 1 , Alexey N. Bashkatov1, Dar ia K. Tuchina 1, Elina A. Genina 1, Valer y V. 39 Tuchin 1 1 Saratov State University, Saratov R ussia P2 .2 6 . Blood Plasma of Patients with Myelodysplastic Syndromes analysed by Surface Plasmon Resonance Imaging and Mass Spectrometry J an E. Dyr 1, Leona Chr astinova 1, Mar keta Bockova 2, Hana Vaisocher ova 2, Ondr ej P astva 1, J ir i Suttnar 1, Roman Kotlin 1, J ir i Homola 2 1 Institute of Hematology and Blood T ransfusion, Prague, Czech R epublic, 2Institute of Photonics and Electronics, Academy of Sciences of the Czech R epublic, Prague, Czech R epublic P2 .2 7 . Influence of gold nanorods parameters on photoacoustic conversion stability Lucia Cavigli1, Sar ah Lai1, Mar ella de Angelis1, Fulvio Ratto1, P aolo Matteini1, Fr ancesca Rossi1, Sonia Centi1 and Rober to P ini1 1 Institute of Applied Physics IFAC-CNR , Florence Italy P2 .2 8 . Feasibility of plasmonic cellular vehicles for photothermal and photoacoustic applications C. Bor r i1,2, L. Cavigli1, A. Cini1,3, S. Centi1, S. Lai1, F. Tatini1, F. Ratto1, M. de Angelis1, P . Matteini1, S. Colagr ande2, R. P ini1 1 Institute of Applied Physics IFAC-CNR , Florence Italy, 2Dipartimento di Scienze Biomediche, Sperimentali e Cliniche Mario Serio, Università di Firenze, Firenze (Italy) , 3 Dipartimento di Fisica e Astronomia, Università di Firenze, Sesto Fiorentino (Italy) P2 .2 9 . Biological profiles of plasmonic particles modified with a cell penetrating peptide S. Lai1, S. Centi1, C. Bor r i1,2, F. Ratt o1, F. Tatini1, S. Colagr ande2, R. P ini1 1 Institute of Applied Physics IFAC-CNR , Florence Italy, 2Dipartimento di Scienze Biomediche, Sperimentali e Cliniche Mario Serio, Università di Firenze, Firenze (Italy) P2 .3 0 . Planar optical antenna to direct light emission Simona Checcucci1, Sahr ish Rizvi1, P ietr o Lombar di1,2, Fabr izio Sgr ignuoli1,3, Costanza Toninelli1,2, Mar io Agio1,2,4 1 European Laboratory for Nonlinear Spectroscopy (LENS), via Nello Carrara 1, 50019 Sesto Fiorentino, IT ALY, 2National Institute of Optics (CNR -INO), Firenze LENS Unit, via Nello Carrara 1, 50019 Sesto Fiorentino, IT ALY, 3Department of Physics and Astronomy, University of Florence, via Sansone 1, 50019 Sesto Fiorentino, IT ALY, 4 Department of Physics, University of Siegen, Walter-Flex-Str. 3, 57072 Siegen, GER MANY 40 Instructions for Presenters Oral Presentations Invited talk: 20 minutes pr esentation + 5 minutes discussion. Contr ibuted talk: 12 minutes pr esentation + 3 minutes discussion. Poster Presentations P oster s may be set up in the mor ning befor e the coffee br eak. Author s ar e r equested to be pr esent at their poster s dur ing the poster session. Poster size width: max 100 cm. height: min 85 cm, max 116 cm. 41 Information For Partecipants CONFERENCE VENUE The confer ence is hosted at the “Nello Car r ar a” Institute of Applied P hysics (IFAC) within the Flor ence Resear ch Ar ea of the National Resear ch Council (CNR). A shuttle bus ser vice fr om Santa Mar ia Novella tr ain station to the confer ence venue will be or ganized ever y day, in the mor ning and in the after noon at the end of scientific sessions. Alter natively, you can r each the Confer ence Ar ea, which is located at the “P olo Scientifico di Sesto Fior entino” by bus no. 66 fr om Sesto Fior entino tr ain station or no. 59 fr om Fir enze Rifr edi station. Bus tickets ar e sold in tobacco shops or at the ATAF ticket office within Santa Mar ia Novella. Tickets can be pur chased also onboar d, but at a higher pr ice. P lease note that the public tr anspor tations can take up to one hour to r each the Confer ence venue, because of the combination between tr ain and bus timetables, which var y dur ing the day. Ther efor e, we encour age the use of the shuttle for your convenience. SOCIAL DINNER BioP hotonics 2015 social dinner will take place on May 21th at the r estaur ant “Lo Spaccio”, inside the “Fattor ia di Maiano”. The Fattor ia, whose or igins date back to 1400, is located on a unique position on Fiesole hills. It is a completely or ganic agr icultur al estate, which cover s an ar ea of near ly 300 hectar es mainly used for gr owing olives. J ust inside the estate, the r estaur ant Lo Spaccio is a cor ner of flavour wher e you can taste typical Tuscan delicatessen. Outfitted with a panor amic ter r ace and cosy inside r ooms, the r estaur ant will be the per fect location to enjoy a cultur al and scientific exchange dur ing the social dinner . 42
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